CN104055817B - A kind of composition and its atomization preparation with calm effect - Google Patents
A kind of composition and its atomization preparation with calm effect Download PDFInfo
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- CN104055817B CN104055817B CN201310088066.6A CN201310088066A CN104055817B CN 104055817 B CN104055817 B CN 104055817B CN 201310088066 A CN201310088066 A CN 201310088066A CN 104055817 B CN104055817 B CN 104055817B
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- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of composition and its atomization preparation with calm effect.The composition includes spring flower chrysanthemum volatile oil or lavenderessential oil and Tea Polyphenols and vitamin E, and the composition has calm, effect of calming the nerves, had no toxic side effect, and stability is strong, it is easy to is absorbed by the body, can effectively suppress the symptoms such as neurasthenia.
Description
Technical field
The present invention relates to field of medicaments, there is the composition of calm effect and use said composition more particularly, to a kind of
Atomization preparation.
Background technology
Modern social economy high speed development, urbanization rhythm and process of industrialization are accelerated, and the rhythm of life of people is also continuous
Accelerate and pressure is also increasing, increasing people occur anxiety, worry, be entangled with, have a sleepless night, it is nervous, depressed, manic etc.
Neurasthenia symptom.According to incompletely statistics, the neurasthenic incidence of disease accounts for more than the 10% of normal population in developing country,
Developed country is then up to 20%, and neurasthenia has had a strong impact on the quality of life of people.
Neurasthenia can directly result in the infringement of the multiple systems of human body, and trigger hypertension, arrhythmia cordis, cerebrovascular disease
The diseases such as disease, diabetes and nephrosis.At present, clinical medicine application such as alprazolam, triazolam, clonazepam, Shu Lean mostly
The stable class medicines such as fixed, midazolam are used as the treatment means for suppressing such as insomnia nervous breakdown.These medicines are in a short time
Just it can take effect, but human body has obvious dependence for this kind of medicine, just make it that the symptoms such as insomnia are serious all the more once disabling；And
And this kind of medicine has larger side effect, long-term taking can then cause poisoning, induce the bad diseases such as maniac access, orgasm decline
Shape, more severe patient then directly result in central nervous system and are damaged, and patient the feelings such as headache, drowsiness, dizziness, memory decline is occurred
Condition；For pregnant woman, then fetal anomaly can be caused to have cleft palate, harelip or indirect inguinal hernia.Neurasthenia is obstinate and refractory, and such as insomnia is just
It is referred to as " not dead cancer ".In view of Western medicine uses upper limitation and adverse reaction in treatment neurasthenia, in natural
The neurasthenia medicine that herbal medicine develops new Small side effects is an important directions of current this area research.For example, Chinese
Patent Application Publication CN1569059A discloses a kind of oral formulations of use using the extract of Eupatorium adenophorum as main component and controlled
Treat the technical scheme of insomnia.
In the research of above-mentioned utilization Chinese herbal medicine, plants essential oil is extracted from natural plants, is configured to compound medicine to control
It is the focus studied at present to treat neurasthenia.So-called plants essential oil is carried in referring to the flower from plant, leaf, stem, root or fruit
Refine the volatile flavor of extraction.Plants essential oil is changed without artificial essence, artificial color, synthetic preservative, mineral grease etc.
Study point, be typically considered to be difficult to cause human allergy etc..In plants essential oil, Lavender and chrysanthemum chrysanthemum essential oil are because of them
Good pharmacological effect and have no toxic side effect and be loved by people.
Lavender（Lavender）, its leaf, stem, flower complete stool soft, stingless excitation, nontoxic pair in giving off a strong fragrance, aromatic flavour
Effect, is precious Chinese medicine and food flavor.Essential oil content is higher in lavender, and the main component of essential oil is linalool, second
The compounds such as sour virtue camphor tree ester, acetic acid lavender ester and lavender alcohol.Pharmacological research shows that Lavender has relaxation smooth
Flesh, anticonvulsion, calm, antidepression etc. are acted on, and can replace hypnotic, can also be promoted cytothesis, balance sebum secretion, be repaiied
Multiple calcination and sunburn, it is anti-infective；Its fragrance, which can improve a poor appetite, strengthens healthy, and has oxidation resistant efficiency, is widely used
In medicine, health care, cosmetic, washing, food service industry.For example, Chinese patent application document CN102416109A discloses a kind of bag
Compound essential oil containing components such as Lavender, grape-kernel oil, vitamin E, propolis, vitamin B1, wheat-germ oil, dextrin is helped
Dormancy capsule, it has effects that calming soporific.Chinese patent application document CN10163276A discloses one kind and carried comprising grass-leaved sweetflag
Take the components such as thing, Fructus Anisi Stellati extract, Herba Schizonepetae extract folium eucalypti extract, camphor leaf extract, lavender sesame oil, peppermint oil
There is the essential oil of traditional Chinese medicine of effect of calming the nerves.
Yellow chamomile（Chamomile）, it contains volatile aromatic oil, is a kind of important medicinal plant and spice berry.
Yellow chamomile volatile oil, is popular health care and pharmaceutical preparation, have functions that it is calm, loosen, help sleep, can alleviate anxiety,
Nervous, indignation and fear；Making one to loosen has patience, happy and auspicious, makes soul tranquil；And yellow chamomile has stronger anti-inflammatory activity, energy
Alleviate inflammation, pain and the symptom such as insomnia as caused by neurotic skin itch of patient；Yellow chamomile also has anti-inflammatory simultaneously
With the effect for suppressing fungi.Yellow chamomile volatile oil have concurrently uniqueness fragrance, in Europe, yellow chamomile is often made into tea bag, with
In treatment insomnia, laryngitis, sciatica, indigestion or applied in cosmetics such as lipstick, medicated soap, suntan lotion, shampoo,
Fragrance can be produced and skin cracks, inflammation can be prevented, played a protective role, and be incorporated then can effectively treat tooth in gargle
Bitterly.In addition, yellow chamomile volatile oil has fragrant as natural rose and can be used as the flavor enhancement of food, beverage and sweet wine.
However, natural plant volatile oil volatility is big, stability and absorption of human body are poor, even if the forms such as capsule are made,
Human body is still difficult for be absorbed.Now as pharmaceutical, it is not notable for treating neurasthenic curative effect.Thus, how
The stability of plant volatile oil is improved, and makes it preferably be absorption of human body, treatment neurasthenia symptom curative effect is improved, in medical science
Field is significant for treatment neurasthenia symptom.
The content of the invention
The present invention provides a kind of composition and its atomization preparation with calm effect having no toxic side effect.The composition
Include spring flower chrysanthemum volatile oil or lavenderessential oil and Tea Polyphenols and pharmaceutical excipient.The composition stability is strong, easily
In being absorbed by the body, it can effectively suppress the symptoms such as neurasthenia.
Alternatively, the excipient is diluent.
Alternatively, the diluent is propane diols.
Alternatively, the composition also includes vitamin E so that as stabilizer, alleviation yellow chamomile volatile oil or lavender are waved
The oxidation of hair oil, Tea Polyphenols.
Alternatively, the composition contains 0.01~1 weight % yellow chamomile volatile oil or lavenderessential oil, and 0.01
The vitamin E of~10 weight % Tea Polyphenols and 0~2 weight %.
Alternatively, the composition contains 0.03~0.8 weight % yellow chamomile volatile oil or lavenderessential oil.And
0.01~5 weight % Tea Polyphenols, and 0.5~1.5 weight % vitamin E.
Alternatively, the composition contains 0.4~0.7 weight % yellow chamomile volatile oil or lavenderessential oil, and 0.2
The vitamin E of~0.8 weight % Tea Polyphenols and 0.8~1.5 weight %.
Alternatively, the yellow chamomile volatile oil or lavenderessential oil are the water distillation of yellow chamomile dried flower or lavender dried flower
Extract,
The spring flower chrysanthemum volatile oil or lavenderessential oil are obtained using the following method：
After yellow chamomile dried flower or lavender dried flower are crushed, it is soaked in water 2.5~4 hours；Then steam distillation 2 is used
~4 hours, distillate cooling and stratification obtain extracting yellow chamomile dried flower or lavenderessential oil, and dry.
Alternatively, after the yellow chamomile dried flower or lavender dried flower are crushed, 40 mesh sieves are crossed, dried flower powder is obtained, it is described dry
The solid-liquid ratio of pollen end and water is 1:16~24.
Alternatively, vacuum distillation after the Tea Polyphenols after green tea is crushed with aqueous alcohol solutions by being extracted, then use
Chloroform is extracted and obtained.
Alternatively, the method for acquisition Tea Polyphenols is from green tea：
Green tea powder is secondary with 60~80vol% alcohol reflux, merge extract solution, decompression evaporates ethanol；
After filtering or being centrifuged off impurity, the extract solution is further concentrated；
After afterwards mixing the extract solution and chloroform, stratification obtains the upper strata aqueous solution；
The upper strata aqueous solution is freeze-dried, Tea Polyphenols powder is obtained.
Present invention also offers a kind of atomization preparation, it includes the above-mentioned composition with calm effect.
Compared with prior art, the present invention has advantages below：
Determined through mouse experiment, of the invention contains yellow chamomile volatile oil or lavenderessential oil, and vitamin E and tea
Polyphenol has the composition of calm effect compared to only containing yellow chamomile volatile oil or lavenderessential oil and vitamin E
Example is compared, under identical circumstances, the sleep that the composition with calm effect that the present invention is provided can substantially shorten mouse is dived
Fu Qi, extends the length of one's sleep, improves mice sleep quality；Mouse number of activities can be reduced simultaneously, stablizes mouse mood well.
It was found from being tested more than,
The present invention has calm, effect of calming the nerves, and effectively suppresses mouse Nerve debilitating symptoms.
In addition, the atomization preparation for containing the composition with calm effect of the present invention is conducive to human body for calm effect
Composition absorption, so as to improve, composition is calm, effect of calming the nerves.
Embodiment
Composition provided by the present invention with calm effect, with yellow chamomile volatile oil or lavenderessential oil and tea
Polyphenol and pharmaceutical excipient are main component.Wherein, the excipient is preferably diluent, selected from alcohols, such as ethanol, second two
Alcohol, normal propyl alcohol, n-butanol etc..Wherein, preferably propane diols is used as diluent.
The yellow chamomile volatile oil and lavenderessential oil that can be used in the present invention are the distillate obtained with hydrodistillation.
Its method is as follows：
Step 1：After yellow chamomile dried flower or lavender dried flower are crushed, it is soaked in appropriate water 2.5~4 hours；
Step 2：By above-mentioned soak ebuillition of heated 2~3 hours, and distillate is cooled down, obtain cut；Stand cut,
It is layered, the oil reservoir on upper strata is extracted；
Step 3：Natrium carbonicum calcinatum is added in the oil reservoir of extraction to dry, and yellow chamomile dried flower or lavender are obtained after filtering
Volatile oil.
Wherein, after the yellow chamomile dried flower or lavender dried flower are crushed, the powder obtained after crushing is crossed into 40 mesh sieves, obtained
To the less yellow chamomile dried flower of particle or lavender dried flower powder, it is immersed in again in water afterwards, is so easy to yellow chamomile volatile oil
Or lavenderessential oil is extracted.And the solid-liquid ratio of yellow chamomile dried flower powder or lavender dried flower powder and the water for soaking is excellent
Elect 1 as:16~24.If the content of water is too small, the extraction of yellow chamomile volatile oil or lavenderessential oil is not abundant enough；Cross at most
Depleting substance is excessive, and the energy consumption of distillation operation is also accordingly improved afterwards, causes to waste.Soak time is then according to specific thing
Material is than determining.Wherein, the solid-liquid ratio is more preferably 1:20 or so.
It is worth noting that, the spring flower chrysanthemum place of production includes Germany, Britain, Morocco, Hungary, Russia, Yugoslavia etc.
The all state in Europe, also largely cultivates in Xinjiang, China Yi Li and other places, extracted in the yellow chamomile in the different place of production spring flower chrysanthemum volatile oil into
Divide and be slightly different, it, which is applied to the present invention, has the also slightly difference, but these are thin of calm effect after the composition of calm effect
Elementary errors does not have no effect on the object of the invention realization.Equally, lavenderessential oil is also such.
The yellow chamomile volatile oil and lavenderessential oil that can be used in the present invention in addition to being obtained using the above method,
Commercially available yellow chamomile volatile oil and lavenderessential oil can be used, such as Xi'an rising sun Science and Technology Ltd. is overcritical
Yellow chamomile essential oil, the Lavender of lavender technological development Co., Ltd of Shenzhen.They in the present invention can be substantially equal
It is efficiently used.
The Tea Polyphenols used in the present invention is obtained to be extracted after green tea is crushed with aqueous alcohol solutions with chloroform extraction
The product obtained.Its detailed process includes：
Step 1：Green tea powder is secondary with 60~80vol% alcohol reflux, merge extract solution, decompression evaporates second
Alcohol, obtains extract solution.
Wherein, secondary alcohol reflux process can be that a 70vol% left sides for 7~9 times of volumes are first added in green tea powder
Right ethanol, flows back 2 hours or so；Second of same pure ethanol with 6~8 times of volumes flows back 1 hour or so, and merges twice
Flow back the extract solution obtained；
The extract solution obtained by above-mentioned alcohol reflux twice is filtered afterwards, the filtrate of acquisition evaporates ethanol through decompression, obtains
To extract solution.
Step 2：By said extracted liquid through filtering or rotary process, to remove after the insoluble matter impurity in extract solution, it will filter
Liquid carries out enrichment process, sloughs part water.
Step 3：By the extract solution obtained in step 2 and chloroform with 3:2 or so volume ratio mixing, and after being sufficiently stirred for,
Stand, to mixed solution layering, obtain the upper strata aqueous solution.Afterwards using water-soluble to the upper strata of acquisition by flat plate ultrafiltration equipment
Liquid carries out clarifying treatment, obtains settled solution.
Step 4：Obtained settled solution is subjected to freeze-drying process, Tea Polyphenols powder is obtained.
The Tea Polyphenols that can be used in the present invention in addition to it can prepare in aforementioned manners, it is possible to use commercially available
Product, such as Anhui Red Star medicine company Co., Ltd, 50%EGCG Tea Polyphenols.Can also be carried with supercritical carbon dioxide
The Tea Polyphenols for taking method to obtain.They can be used substantially equally effectively in the present invention.
Preferably, the composition with calm effect of the invention also includes vitamin E.Wherein, it is described that there is calmness
The composition of effect includes 0.01~1 weight % yellow chamomile volatile oil or lavenderessential oil, and 0.01~10 weight %
Tea Polyphenols and 0~2 weight % vitamin E %.Preferably, the composition includes 0.03~0.8 weight % yellow chamomile
Volatile oil or lavenderessential oil, and 0.01~5 weight % Tea Polyphenols and 0.5~1.5 weight % vitamin E.It is more excellent
Selection of land, the composition contains 0.4~0.7 weight % yellow chamomile volatile oil or lavenderessential oil, and 0.2~0.8 weight
Measure % Tea Polyphenols and 0.8~1.5 weight % vitamin E.
The present invention has in the composition of calm effect, and yellow chamomile volatile oil or lavenderessential oil have calm work(
Effect, Tea Polyphenols have it is efficient calm, suppress the irritated mood of people to suppress the neurasthenic effect of people, by yellow chamomile volatile oil or
Lavenderessential oil merges with Tea Polyphenols, and adds certain vitamin E with antioxidation, then is mixed with diluent
Afterwards, effect beneficial to human body is added with yellow chamomile volatile oil or lavenderessential oil and diluent than single in the past.And
Both Tea Polyphenols and vitamin E have antioxidation, and the function with Synergistic not only preferably protects volatile oil
Stability, while also improving composition effect.
Wherein, the composition that the present invention has calm effect may also include such as Rhizoma Acori Graminei extract, Herba Schizonepetae extract folium eucalypti
The traditional Chinese medicine ingredients such as extract, peppermint oil, and such as vitamin B1 composition with strengthen the present invention effect.
There is the present invention composition of calm effect can be made into suitable for oral administration, intravenous injection administration, sublingual administration
Etc. various pharmaceutical dosage forms.Used in forms such as solid, solution, emulsion, dispersion, micella, liposomes.Shape specifically can be used
Formula includes tablet, granule, pill, capsule, lozenge, aqueous suspension or oil suspending agent, tincture, dispersible pulvis, solution, breast
Agent, suspending agent and other suitable forms.Wherein, particularly preferably comprising above-mentioned there is calm effect the invention provides a kind of
The atomization preparation of composition.It can be by yellow chamomile volatile oil or lavenderessential oil, Tea Polyphenols, vitamin containing aforementioned proportion
E is mixed, and compound atomization preparation is made, and Alevaire form is made and is used using medical atomized equipment and electronic cigarette.
It is above-mentioned to have the composition of calm effect in the form of Alevaire in use, human body is inhaled by being atomized comprising above-mentioned
Receive, the active ingredient of yellow chamomile or lavender is directly absorbed into blood, composition is more easy to and plays its effect.Specifically, mist
After agent suction nasal cavity, the olfactory epithelium of nasal cavity upper back is passed to by nasal meatus, then is transferred to olfactory bulb, olfactory cortex is delivered to, then
Send instruction via brain centres nerve, go and balance automatic nervous system, thus produce it is calm, loosen, please or emerging
The effect put forth energy.Thus Alevaire causes human body to absorb more abundant for the composition active ingredient of calm effect, and these have
Imitate composition in human body action time faster so that preferably play it is calm, loosen, calm nerves, ease off the pressure, promote to sleep
The effects such as.Meanwhile, Tea Polyphenols is a kind of natural polyphenol class material extracted from tealeaves, with good anti-oxidant and removing certainly
By the ability of base, lung is also sucked by Alevaire, enters blood circulation system in lung, removing free radical is played, machine is reduced
Body lipid extent of peroxidation, pre- anti-aging effect.Yellow chamomile volatile oil or lavender volatile oil have the fragrance of uniqueness concurrently, more
Easily it is esthetically acceptable to the consumers.
In addition, atomization dosage form is convenient using process, without dilution, prepares, substantially reduces the possibility during use
Microorganism pollution so that the Alevaire product that provides of the present invention uses safer, hygienic, conveniently.
We further describe the present invention by specific embodiment and experiment below, and still, following embodiments are only
The example of the present invention, and it is not considered as limiting the scope of the invention.
Embodiment 1
It is prepared by Tea Polyphenols：
Commercially available Longjing green tea tealeaves 5kg is taken, pulverizer coarse crushing is used.With the aqueous solution refluxing extraction of the ethanol containing 70vol%
Twice, the 1st time plus the ethanol-water solution equivalent to 8 times of volumes of green tea, flow back 2 hours, the second of 7 times of volumes of the 2nd use
Alcohol-water solution, flows back 1 hour, merges the extract solution that the above-mentioned ethanol-water solution of addition twice is flowed back and obtained.To carrying
Take after liquid filtering, filtrate decompression is distilled, reclaim ethanol, collect extract solution；
By said extracted liquid after filtering off and removing insoluble matter, the extract solution is concentrated, part water is removed, for lower road work
Sequence.Afterwards, by chloroform and extract solution according to volume ratio 3：2 mixing, through being sufficiently stirred for and after stratification, taking the upper strata aqueous solution；
Clarifying treatment is carried out to the upper strata aqueous solution with flat plate ultrafiltration equipment, clarified solution is obtained；Clarified solution is freeze-dried, obtained
Tea polyphenol powder 540g.
It is prepared by yellow chamomile volatile oil：
Weigh yellow chamomile dried flower（Originate in Xuancheng Profile, anhui Province.Air-dried under about 25 DEG C of normal temperature by 1 week）5kg, pulverizer powder
It is broken, 40 mesh sieves are crossed, 100L water is added and soaks 3 hours.With steam distillation 3 hours, distillate is collected, through stratification, is collected
Upper strata oil reservoir；
Anhydrous sodium sulfate drying is added into oil reservoir, dry yellow chamomile volatile oil 42g is obtained.
By the parts by weight of yellow chamomile volatile oil 0.5 obtained above, the parts by weight of Tea Polyphenols 0.5 and vitamin e1 .0 parts by weight with
And the mixing of the parts by weight of propane diols 98, Alevaire 1 is made（Formula 1）.
Embodiment 2
It is prepared by lavenderessential oil：
Weigh lavender dried flower（Originate in Xinjiang Yili of China.Air-dried under about 25 DEG C of normal temperature by 1 week）5kg, pulverizer powder
It is broken, 40 mesh sieves are crossed, 80L water is added and soaks 3 hours.With steam distillation 3.5 hours, distillate is collected, through stratification, is collected
Upper strata oil reservoir.
Anhydrous sodium sulfate drying is added into oil reservoir, dry lavenderessential oil 45g is obtained.
By the obtained parts by weight of Tea Polyphenols 0.5 in the parts by weight of lavender volatile oil 0.5 obtained above, embodiment 1 and dimension
Raw element E1.0 parts by weight and the parts by weight of propane diols 98 mixing, is made Alevaire 2（Formula 2）.
Embodiment 3
It is prepared by lavenderessential oil：
Weigh lavender dried flower（Originate in Xinjiang Yili of China.Air-dried under about 25 DEG C of normal temperature by 1 week）5kg, pulverizer powder
It is broken, 40 mesh sieves are crossed, 100L water is added and soaks 3 hours.With steam distillation 3 hours, distillate is collected, through stratification, is collected
Upper strata oil reservoir；
Anhydrous sodium sulfate drying is added into oil reservoir, dry lavenderessential oil 41g is obtained.
The obtained parts by weight of Tea Polyphenols 10 in the parts by weight of lavender volatile oil 1.0 obtained above, embodiment 1 are given birth to dimension
Plain E1.0 parts by weight and the mixing of the parts by weight of propane diols 88, are made Alevaire 3.
Pharmacological evaluation is carried out with the Alevaire obtained in embodiment 1 and embodiment 2.
Pharmacological experimental example 1
1. reagent and instrument：
Fumigation device：Make 80cm × 40cm × 36cm wooden cases by oneself.Wherein, centre is divided into two halves with wire netting, while putting
Put Fragrance Lamp（Guangzhou Ao Te Electronic Science and Technology Co., Ltd.s produce）, while for placing mouse, being left in the side lower part of wooden case logical
Stomata, top sets glass sliding door with convenient to operate and observation.
Measuring instrument：YLS-1A Multifunctional mouse autonomic activities recorders（Jinan Yi Yan development in science and technology Co., Ltd, former mountain
Dong Sheng Academy of Medical Sciences equipment station is produced）.
Sedative：Yellow Jackets；
Alevaire：Formula 1 is that the Alevaire 1 of embodiment 1, formula 2 are the Alevaire 2 of embodiment 2, matching somebody with somebody as a comparison case
Side 3 and formula 4 are respectively not contain Tea Polyphenols, and obtained yellow chamomile volatile oil and lavender in Examples 1 and 2 are only contained respectively
The Alevaire of volatile oil, formula 5 is without Alevaire any in yellow chamomile volatile oil and lavenderessential oil（Specific formula
Composition is as shown in table 1）.
The Alevaire of 1.5 kinds of different formulations of table
Animal：No specific pathogens (SPF) level KM male mices（22~26g of body weight）.
2. experimental method：
2.1. mouse yellow Jackets induced hypnotic time and incubation period are tested, its specific operation process is：
Mouse is divided to 6 groups, Alevaire at random（As the formula 1 and formula 2 of embodiment, formula 3 as a comparison case, match somebody with somebody
Side 4 and formula 5）Group and control group（Do not implement stacte）, every group 10.Control group gives 50mg/kg Nembutal sodium solution
Intraperitoneal injection；Champignon group respectively according to 5 kinds of Formulation Implementation champignon 30min after, 50mg/kg Nembutal sodium solution is given immediately
Intraperitoneal injection.
Observe and record the dropping asleep latency of mouse（Sleeping duration）And the length of one's sleep（Righting reflex loss is extremely
The time of recovery）.
2.2. to the influence of mouse autonomic activities
Mouse is divided to 6 groups, Alevaire at random（Formula 1, formula 2, formula 3, formula 4, formula 5）Group and control group（It is unreal
Apply stacte）, every group 10.Control group mice does not implement champignon, and champignon group mouse is respectively according to 5 kinds of Formulation Implementation champignon 30min
Afterwards.Mouse is put into mouse autonomic activities number of times in YLS-1A Multifunctional mouse autonomic activities recorders, record 10min.
All experimental datas are usedRepresent, using one-way analysis of variance, P ＜ 0.05 are that difference is statistically significant.
3. experimental result
3.1 is as shown in table 2 on the experimental data of mouse yellow Jackets induced hypnotic time and preclinical influence.
The each group mouse threshold dose yellow Jackets length of one's sleep of table 2. compares
As shown in table 2：In the sleep laboratory that threshold dose yellow Jackets are induced, compared with control group, embodiment is used as
1 group of formula, formula 2 groups and 3 groups of formula as a comparison case, formula 4 groups in mouse after Alevaire champignon, sleep latency
Phase shortens, and the length of one's sleep extends, and difference has statistical significance（P ＜ 0.05）.Simultaneously as 1 group of ratio of formula of embodiment
3 groups of mouse of formula as a comparison case, the sleep of the mouse of 4 groups of the formula of comparative example is used for as 2 groups of the formula of embodiment
Incubation period is shorter, and the length of one's sleep more extends, significant difference（P ＜ 0.05）.The mouse in 5 groups of formula as a comparison case is through mist
After agent champignon, its Sleep latency and the length of one's sleep with the Sleep latency of the mouse in control group and compared with the length of one's sleep,
No significant difference.
The experimental data of the influence of 3.2 pairs of mouse autonomic activitieses is as shown in table 3.
The comparison of each group times of exercise of table 3.
As shown in table 3：It is used as 1 group of formula, 2 groups of formula and 3 groups of formula as a comparison case, the formula 4 of embodiment
After the Alevaire champignon of group, the times of exercise of mouse is considerably less than control group（P ＜ 0.05）.Moreover, being used as the formula 1 of embodiment
The formula 3 of comparative example is used for, the formula 4 of comparative example is used for as the formula 2 of embodiment, it is small after with Alevaire champignon
The times of exercise of mouse is more reduced.But after the Alevaire champignon for being used as the formula 5 of comparative example, to the autonomic activities of mouse without bright
Development rings.
The above results show that the Alevaire containing Lavender and the Alevaire containing yellow chamomile essential oil have calmness to urge
Dormancy is acted on, but after addition Tea Polyphenols, its calm, effect of calming the nerves is significantly improved, hence it is evident that beyond exclusive use Lavender or spring
The effect of yellow chrysanthemum essential oil, or even beyond the effect and the effect using Tea Polyphenols that Lavender or yellow chamomile essential oil is used alone
Simple superposition sum, display Lavender and yellow chamomile essential oil and Tea Polyphenols have synergistic function.Its mechanism is still not
Understand, but speculate to be probably activity that Tea Polyphenols anti-oxidant, the effect of scavenging radical that have improve cell, so that with smoking clothing
The sedation of grass and the essential oil of yellow chamomile generates the effect of Synergistic.It is worth noting that, in the various embodiments described above
Vitamin E is with the addition of, it can effectively protect active ingredient in composition of the present invention with calm effect（Including yellow chamomile volatilization
Oil, lavenderessential oil, Tea Polyphenols）Not oxidized, improving the present invention has the stable effect of composition of calm effect.
Above-mentioned specific embodiment is intended merely to the essence for making those skilled in the art more fully understand the present invention, however, this
The protection domain of invention is not limited with the specific descriptions of these specific embodiments, in the scope for not departing from essence of the invention,
Those skilled in the art can be modified and change to the embodiment of the present invention, and these modifications and changes are still fallen within
Protection scope of the present invention.
Claims (8)
1. a kind of composition with calm effect, it is characterised in that the composition contains 0.01 ~ 1 weight % yellow chamomile
Volatile oil or lavenderessential oil, 0.01 ~ 10 weight % Tea Polyphenols, 0 ~ 2 weight % vitamin E, and pharmaceutical excipient.
2. the composition as claimed in claim 1 with calm effect, it is characterised in that the pharmaceutical excipient is dilution
Agent.
3. the composition as claimed in claim 1 with calm effect, it is characterised in that the composition contains 0.4 ~ 0.7
Weight % yellow chamomile volatile oil or lavenderessential oil, 0.2 ~ 0.8 weight % Tea Polyphenols, 0.8 ~ 1.5 weight % dimension life
Plain E.
4. the composition as claimed in claim 1 with calm effect, it is characterised in that the yellow chamomile volatile oil smokes clothing
Careless volatile oil is the water distillation extract of yellow chamomile dried flower or lavender dried flower,
Obtain by the following method：
After yellow chamomile dried flower or lavender dried flower are crushed, it is soaked in water 2.5 ~ 4 hours, it is then small with steam distillation 2 ~ 4
When, distillate cooling and stratification are obtained.
5. the composition as claimed in claim 4 with calm effect, it is characterised in that the yellow chamomile dried flower or lavender
After dried flower is crushed, 40 mesh sieves are crossed；
The solid-liquid ratio of dried flower powder and water is 1:16~24.
6. the composition with calm effect as claimed in claim 1, it is characterised in that the Tea Polyphenols is by by green tea tea
Vacuum distillation after leaf is extracted after crushing with aqueous alcohol solutions, then extracted and obtained with chloroform.
7. the composition as claimed in claim 6 with calm effect, it is characterised in that the Tea Polyphenols is obtained using the following method
Arrive：
Green tea powder is secondary with 60 ~ 80vol% alcohol reflux, merge extract solution, decompression evaporates ethanol；
After filtering or being centrifuged off impurity, the extract solution is further concentrated；
After the extract solution and chloroform are mixed, stratification obtains the upper strata aqueous solution；
The upper strata aqueous solution is freeze-dried, Tea Polyphenols powder is obtained.
8. a kind of atomization preparation, it is characterised in that include the combination with calm effect any one of claim 1 ~ 7
Thing.
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| CN104770864B (en) * | 2015-02-13 | 2016-08-24 | 华健 | Electronic atomized liquid that a kind of heat clearing away wets one's whistle and preparation method thereof |
| CN107812107A (en) * | 2017-11-09 | 2018-03-20 | 上海羿康生物科技有限公司 | A kind of atomization preparation containing anti-oxidation function plant extracts of refreshing oneself and its preparation method and application |
| CN110151868A (en) * | 2019-05-28 | 2019-08-23 | 厦门梓素生物科技有限公司 | A kind of essential oil and preparation method thereof of the extract of CBD containing cannabidiol |
| CN113350557A (en) * | 2020-03-06 | 2021-09-07 | 李彤 | Multipurpose aromatherapy liquid |
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| CN101632761A (en) * | 2008-11-22 | 2010-01-27 | 中山市中南烛业有限公司 | Nerves-soothing compound oil, essential oil of traditional Chinese medicine and aromatherapy products having nerves-soothing function |
| CN101829240A (en) * | 2010-05-17 | 2010-09-15 | 上海鼎利生物科技有限公司 | Atomizing preparation containing plant extract and preparation method thereof |
| CN102416109A (en) * | 2011-11-18 | 2012-04-18 | 大连得达科技发展有限公司 | Compound essential-oil sleep-helpful capsule |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101632761A (en) * | 2008-11-22 | 2010-01-27 | 中山市中南烛业有限公司 | Nerves-soothing compound oil, essential oil of traditional Chinese medicine and aromatherapy products having nerves-soothing function |
| CN101829240A (en) * | 2010-05-17 | 2010-09-15 | 上海鼎利生物科技有限公司 | Atomizing preparation containing plant extract and preparation method thereof |
| CN102416109A (en) * | 2011-11-18 | 2012-04-18 | 大连得达科技发展有限公司 | Compound essential-oil sleep-helpful capsule |
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