CN104095797B - A kind of Herba Blumeae Balsamiferae compositions of speckle dispelling and application thereof - Google Patents
A kind of Herba Blumeae Balsamiferae compositions of speckle dispelling and application thereof Download PDFInfo
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Abstract
The present invention relates to the Oleum Blumeae Balsamiferae with effect of dispelling spots, comprise the raw material of following weight portion: pure Oleum Blumeae Balsamiferae is used alone, and all compound essential Oil containing Oleum Blumeae Balsamiferae.Pure Oleum Blumeae Balsamiferae 1 part or Oleum Blumeae Balsamiferae assistant reach the effect of speckle dispelling with other plant quintessence oil, Oleum Blumeae Balsamiferae 10 ~ 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 1 ~ 5 part, Flos Rosae Rugosae quintessence oil 1 ~ 5 part.The Oleum Blumeae Balsamiferae with effect of dispelling spots of the present invention, adopt Pure natural plant essential oil or assistant with scientific formula, skin is made effectively to absorb effective ingredient in plants essential oil, improve health skin, the skin splashs such as effective removal freckle, chloasma, sunburn, butterfly spot, black speck, and safe and non-stimulating, have no side effect, can life-time service.
Description
Technical field
The present invention relates to skin care field, specifically, relate to a kind of Herba Blumeae Balsamiferae compositions and application thereof of speckle dispelling.
Background technology
Mottle refers to hyperpigmentation in skin and is common in face in brown or black is pigmented, damage capacitive disease, to appearing at buccal and forehead position in the one formed.To on definite meaning, skin splash comprises the speckle of many types, as chloasma, butterfly spot, black speck, senile plaque, freckle, sunburn, and the hydrargyrum speckle and cyasma etc. except these mottles.For a long time, mottle is one of problem of puzzlement human skin always, and particularly with advancing age, skin occurs that the probability of mottle also obviously increases, and affect the attractive in appearance of health and skin, many cosmetics are more and more subject to people's attention for this reason.
At present, mainly following methods is adopted to the treatment of mottle: 1. physical therapy: the main pigment adopting the method for physics to remove skin surface, and then reach the object of speckle dispelling.The instruments such as general employing photon delicate skin instrument, laser device; 2. western medical treatment method: be generally divided into whole body and topical therapeutic.Whole body therapeutic mainly adopts the chemical substances such as oral or injection vitamin C, and plant extract etc., topical therapeutic mainly uses the reagent such as fruit acid, kojic acid and hydroquinone; 3. Chinese traditional treatment: the traditional Chinese medical science adopts the therapy of the combination of inner and outside, by for oral administration there is blood circulation promoting and blood stasis dispelling, have one's ideas straightened out regulate the flow of vital energy, the Chinese medicine of the effect such as YIN nourishing tonification, reach the effect of conditioning viscera, Yin Yang balancing, be aided with the method for the massage such as meridians, acupuncture point, acupuncture, reach the object of speckle dispelling.In addition, the Chinese medicine patch umbilicus, Chinese medicine fumigation and washing hot compress etc. of spot-removal function can also be had; 4. make to apply some make up: use some to have the cosmetics of effect of dispelling spots, for the nursing of daily skin.
Quintessence oil takes from the extraction elite of the flower of plant, leaf, stem, root or fruit, containing chemical pigment, without essence, does not contain antiseptic, there will not be allergic phenomena and is subject to the favor of people gradually.Quintessence oil is widely used at Cosmetic Market, major part is effect type quintessence oil, but there is specific function and the speckle dispelling essential oil product of special effect still scarcity, need suitable speckle dispelling quintessence oil badly with the personage that likes to be beautiful of mottle " mutually exclusive " and expel the mottle making us perplexing.
Herba Blumeae Balsamiferae Blumeabalsamifera (L.) DC. is the fresh of feverfew Herba Blumeae Balsamiferae or dry aerial parts, another name Balsamiferou Blumea Herb etc., one of the Li nationality of China, Miao ethnic group's folk medicine, be widely used in the mottles such as women face sunburn and chloasma, skin burn, skin cutter, gunshot wound, the treatment of women's aversion to wind in puerperal etc. and control.Have the effect such as promoting blood circulation and detoxication, detumescence dissipating blood stasis, bacterio static itching-relieving, restoration care, body shaping deodorization, expelling wind and removing dampness, most mountain area and rural women all know this function.And Oleum Blumeae Balsamiferae stems from the extraction elite of pure natural plant Herba Blumeae Balsamiferae, containing plurality of active ingredients, outward can not only sterilizing and itch-relieving for skin, and there is desalination mottle, the effect of maintenance skin scar, the demand of people for speckle dispelling essential oil product can be met.
Summary of the invention
The object of this invention is to provide a kind of Herba Blumeae Balsamiferae compositions of speckle dispelling.
The present invention also aims to the application that said composition is provided.
In order to realize object of the present invention, the invention provides a kind of Herba Blumeae Balsamiferae compositions of speckle dispelling, comprising Oleum Blumeae Balsamiferae.
Preferably, the Herba Blumeae Balsamiferae compositions of speckle dispelling of the present invention, described compositions also comprises Herba Lysimachiae foenum-graeci quintessence oil and Flos Rosae Rugosae quintessence oil.
More preferably, the Herba Blumeae Balsamiferae compositions of speckle dispelling of the present invention, by weight, Oleum Blumeae Balsamiferae 10 ~ 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 1 ~ 5 part, Flos Rosae Rugosae quintessence oil 1 ~ 5 part.
Most preferably, the Herba Blumeae Balsamiferae compositions of speckle dispelling of the present invention, by weight, Oleum Blumeae Balsamiferae 20, Herba Lysimachiae foenum-graeci quintessence oil 5 parts, Flos Rosae Rugosae quintessence oil 5 parts.
Preferably, described compositions can directly or use the medium indirect application such as other cotton pads in facial skin.
Described Oleum Blumeae Balsamiferae is prepared by following method: pulverized by Herba Blumeae Balsamiferae, under the condition of solid-liquid ratio 1:10, at room temperature 2h is soaked with ether, be distilled to till solvent no longer flows out under the condition of Extracting temperature 40 DEG C, then be placed in the dry 30min of thermostatic drying chamber, thus obtain Oleum Blumeae Balsamiferae;
Described Herba Lysimachiae foenum-graeci quintessence oil is prepared by following method: get dry lavandula angustifolia, be first cut into the coarse fragments of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain lavandula angustifolia powder, then the Oleum Blumeae Balsamiferae prepared above adding in described lavandula angustifolia powder is as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is 20:1, then the mixture of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 12g/min, extraction kettle pressure is 25Mpa, temperature is 40 DEG C, the pressure of adjustment separating still is 3Mpa, temperature is 40 DEG C, circulation is extracted and disengaging time is 3h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Herba Lysimachiae foenum-graeci quintessence oil is obtained,
Described Flos Rosae Rugosae quintessence oil is prepared by following method: get dry Flos Rosae Rugosae, be first cut into the fragment of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain Flos Rosae Rugosae powder, then the Oleum Blumeae Balsamiferae prepared above adding in described Flos Rosae Rugosae powder is as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is 25:1, then the mixture of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 14g/min, extraction kettle pressure is 23Mpa, temperature is 42 DEG C, the pressure of adjustment separating still is 3.8Mpa, temperature is 43 DEG C, circulation is extracted and disengaging time is 5h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Flos Rosae Rugosae quintessence oil is obtained.
Find through research, different extracting method can produce a very large impact for the cost of volatile oil and effect, basic reason is that volatile oil cost is very unstable, requirement for solvent, Extracting temperature, extracting method is all higher, prove through test, adopt extracting method of the present invention, the effect of the volatile oil obtained is more good.
The present invention also provides Herba Blumeae Balsamiferae compositions preparing the application in medicine for removing speckle, and described compositions comprises Oleum Blumeae Balsamiferae.
Preferably, described compositions also comprises Herba Lysimachiae foenum-graeci quintessence oil and Flos Rosae Rugosae quintessence oil.
More preferably, by weight, Oleum Blumeae Balsamiferae 10 ~ 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 1 ~ 5 part, Flos Rosae Rugosae quintessence oil 1 ~ 5 part.
Most preferably, by weight, Oleum Blumeae Balsamiferae 20, Herba Lysimachiae foenum-graeci quintessence oil 5 parts, Flos Rosae Rugosae quintessence oil 5 parts.
Preferably, described compositions can directly or use the medium indirect application such as other cotton pads in facial skin.
Beneficial effect of the present invention: the Oleum Blumeae Balsamiferae with effect of dispelling spots of the present invention, adopt Pure natural plant essential oil composition, absorbability is good, both can separately for skin, also can use with other quintessence oil proportionings, all can reach removal mottle, alleviate the effect of facial wrinkles, safe and non-stimulating, can life-time service.
Detailed description of the invention
By embodiment, the invention will be further described, and scope is not limited by embodiments of the present invention.
The Oleum Blumeae Balsamiferae used in the following example is prepared by following method: pulverized by Herba Blumeae Balsamiferae 1kg, under the condition of solid-liquid ratio 1:10, at room temperature 2h is soaked with ether, be distilled to till solvent no longer flows out under the condition of Extracting temperature 40 DEG C, then be placed in the dry 30min of thermostatic drying chamber, thus obtain Oleum Blumeae Balsamiferae;
The Herba Lysimachiae foenum-graeci quintessence oil used in the following example is prepared by following method: get dry lavandula angustifolia 1kg, be first cut into the coarse fragments of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain lavandula angustifolia powder, then the Oleum Blumeae Balsamiferae prepared above adding in described lavandula angustifolia powder is as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is 20:1, then the mixture of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 12g/min, extraction kettle pressure is 25Mpa, temperature is 40 DEG C, the pressure of adjustment separating still is 3Mpa, temperature is 40 DEG C, circulation is extracted and disengaging time is 3h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Herba Lysimachiae foenum-graeci quintessence oil is obtained,
The Flos Rosae Rugosae quintessence oil used in the following example is prepared by following method: get dry Flos Rosae Rugosae 1kg, be first cut into the fragment of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain Flos Rosae Rugosae powder, then the Oleum Blumeae Balsamiferae prepared above adding in described Flos Rosae Rugosae powder is as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is 25:1, then the mixture of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 14g/min, extraction kettle pressure is 23Mpa, temperature is 42 DEG C, the pressure of adjustment separating still is 3.8Mpa, temperature is 43 DEG C, circulation is extracted and disengaging time is 5h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Flos Rosae Rugosae quintessence oil is obtained.
Embodiment 1
Oleum Blumeae Balsamiferae 1 gram is mixed well separately and can directly or be used the medium indirect application such as other cotton pads in facial skin by the Oleum Blumeae Balsamiferae with effect of dispelling spots.
Embodiment 2
There is the manufacture method of the Oleum Blumeae Balsamiferae compound recipe of effect of dispelling spots, comprise the following steps: get Oleum Blumeae Balsamiferae 10 grams, Herba Lysimachiae foenum-graeci quintessence oil 1 gram, Flos Rosae Rugosae quintessence oil 1 gram be placed in container and be uniformly mixed i.e. obtained speckle dispelling quintessence oil of the present invention, can directly or use the medium indirect application such as other cotton pads in facial skin.
Embodiment 3
There is the manufacture method of the Oleum Blumeae Balsamiferae compound recipe of effect of dispelling spots, comprise the following steps: get Oleum Blumeae Balsamiferae 20 grams, Herba Lysimachiae foenum-graeci quintessence oil 5 grams, Flos Rosae Rugosae quintessence oil 5 grams be placed in container and be uniformly mixed i.e. obtained speckle dispelling quintessence oil of the present invention, can directly or use the medium indirect application such as other cotton pads in facial skin.
Embodiment 4
There is the manufacture method of the Oleum Blumeae Balsamiferae compound recipe of effect of dispelling spots, comprise the following steps: get Oleum Blumeae Balsamiferae 15 grams, Herba Lysimachiae foenum-graeci quintessence oil 3 grams, Flos Rosae Rugosae quintessence oil 3 grams be placed in container and be uniformly mixed i.e. obtained speckle dispelling quintessence oil of the present invention, can directly or use the medium indirect application such as other cotton pads in facial skin.
Embodiment 5
There is the manufacture method of the Oleum Blumeae Balsamiferae compound recipe of effect of dispelling spots, comprise the following steps: get Oleum Blumeae Balsamiferae 15 grams, Herba Lysimachiae foenum-graeci quintessence oil 5 grams, Flos Rosae Rugosae quintessence oil 3 grams be placed in container and be uniformly mixed i.e. obtained speckle dispelling quintessence oil of the present invention, can directly or use the medium indirect application such as other cotton pads in facial skin.
Test example
Speckle dispelling quintessence oil is applied in skin, and non-stimulated to skin safe is primary prerequisite.Therefore, the present invention has carried out sensitivity test to the Oleum Blumeae Balsamiferae with effect of dispelling spots, investigates the present invention to the zest of skin.
Skin allergy test
Experiment material
Have the Oleum Blumeae Balsamiferae of effect of dispelling spots, yellow oily liquid, density is 0.935g/mL.Albino guinea pig 40, regular grade, body weight is 250 ~ 300g, and male and female half and half are provided by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center, and the quality certification is SCXK-2008-0020.
Experimental technique
Grouping: Cavia porcellus is divided into 7 groups at random by body weight and sex, often organizes 10, male and female half and half.Speckle dispelling quintessence oil in embodiment 1 to 4 is 1 to 4 group respectively, other 5th group and the 6th group is the blank Vehicle controls group of normal saline and positive sensitizing drugs group (1%2 respectively, 4-dinitrochlorobenzene), before administration, 24h is with 8% sodium sulfide to the depilation of Cavia porcellus spinal column both sides, and the every side of unhairing area is about 3cm × 3cm.
Sensitization contact is got Oleum Blumeae Balsamiferae 0.2mL uniform application and to be lost hair or feathers on the left of guinea pig back district, cover with fluid-tight cellophane, be wound around with binder, fix with medical rubber cream, covering is removed after 6h, wipe only with cotton ball soaked in alcohol. remove test medicine. in kind respectively repeat 1 time respectively at 7d and 14d again, smear 3 times altogether.Blank Vehicle controls group and positive sensitizing drugs group test method the same.
Excite sensitization: 14d after last is to tested material sensitization, by Oleum Blumeae Balsamiferae 0.2mL.Normal saline 0.2mL and 0.1%2,4-dinitrochlorobenzene 0.2mL, coats the depilation district, right side of corresponding animal respectively, removes tested material, at once observe after 6h, then in 24,48,72h observes skin allergy situation again.Mark according to " standards of grading of skin allergy degree ", calculate each treated animal reaction mean scores.To notice whether observe animal has the systemic anaphylaxis such as asthma, astasia simultaneously.By following formulae discovery sensitivity response incidence rate, then evaluate sensitization by " skin hypersensitivity evaluation criterion " according to irritated incidence rate.
Experimental result
Table 1 Oleum Blumeae Balsamiferae anaphylaxis result
There is not the systemic anaphylaxis phenomenon that asthma, astasia or shock etc. are serious in Cavia porcellus within the observation period.After positive controls 10 Cavia porcelluss excite administration, sensitization rate is 100%.And all there is not the reaction such as erythema, edema in embodiment 1 to 4 test group and saline control group within the observation period, the reaction integration of each time point is 0 point, zero difference statistically between two groups, its sensitization rate is 0, compare average response score value there were significant differences with positive controls, shows that the speckle dispelling Oleum Blumeae Balsamiferae in embodiment 1 to 5 does not cause guinea pig skin anaphylaxis.
Test case
The standard of curative effect evaluation
Recovery from illness: mottle all disappears, skin color is close to normal.Effective: mottle color is obviously thin out, there is many places patch shape normal skin in primary colors pinta stove, and the mottle gross area that disappears reaches more than 50% of former focus.Effective: mottle lighter, the area that disappears reaches more than 30% of former focus.Invalid: treatment front and back mottle is substantially unchanged or increase the weight of.
Tested object: each embodiment selects 75 examples to have the patient of mottle, wherein 15 examples are freckle, and 15 examples are chloasma, and 15 examples are sunburn, and 15 examples are butterfly spot, and 15 examples are black speck.
Test result
Test result 1: observe 75 examples, after using the Herba Blumeae Balsamiferae compound spot-eliminating quintessence oil 2,30d in embodiment 2 continuously, result is as table 2.
Table 2 embodiment 1 pure Herba Blumeae Balsamiferae speckle dispelling quintessence oil 1 treats mottle result
| Recovery from illness example | Effective example | Effective example | Invalid example | Total number of cases | Total effective rate | |
| Freckle | 3 | 5 | 5 | 2 | 15 | 86.67％ |
| Chloasma | 5 | 3 | 5 | 2 | 15 | 86.67％ 5 --> |
| Sunburn | 4 | 5 | 5 | 1 | 15 | 93.33％ |
| Butterfly spot | 3 | 6 | 4 | 2 | 15 | 86.67％ |
| Black speck | 4 | 5 | 3 | 3 | 15 | 80.00％ |
Test result 2: observe 75 examples, after using the pure Herba Blumeae Balsamiferae speckle dispelling quintessence oil 1,30d in embodiment 2 continuously, result is as table 3.
Herba Blumeae Balsamiferae compound spot-eliminating quintessence oil 2 in table 3 embodiment 2 treats mottle result
| Recovery from illness example | Effective example | Effective example | Invalid example | Total number of cases | Total effective rate | |
| Freckle | 4 | 5 | 4 | 1 | 15 | 93.33％ |
| Chloasma | 5 | 3 | 5 | 2 | 15 | 86.67％ |
| Sunburn | 4 | 5 | 5 | 1 | 15 | 93.33％ |
| Butterfly spot | 4 | 5 | 4 | 2 | 15 | 86.67％ |
| Black speck | 4 | 5 | 4 | 2 | 15 | 86.67％ |
Test result 3: observe 75 examples, after using the pure Herba Blumeae Balsamiferae speckle dispelling quintessence oil 1,30d in embodiment 3 continuously, result is as table 4.
Herba Blumeae Balsamiferae compound spot-eliminating quintessence oil 3 in table 4 embodiment 3 treats mottle result
| Recovery from illness example | Effective example | Effective example | Invalid example | Total number of cases | Total effective rate | |
| Freckle | 4 | 5 | 4 | 1 | 15 | 93.33％ |
| Chloasma | 5 | 4 | 5 | 1 | 15 | 93.33％ |
| Sunburn | 4 | 5 | 5 | 1 | 15 | 93.33％ |
| Butterfly spot | 3 | 5 | 5 | 2 | 15 | 86.67％ |
| Black speck | 3 | 4 | 5 | 3 | 15 | 80.00％ |
Test result 4: observe 75 examples, after using the pure Herba Blumeae Balsamiferae speckle dispelling quintessence oil 1,30d in embodiment 4 continuously, result is as table 5.
Herba Blumeae Balsamiferae compound spot-eliminating quintessence oil 4 in table 5 embodiment 4 treats mottle result
| Recovery from illness example | Effective example | Effective example | Invalid example | Total number of cases | Total effective rate | |
| Freckle | 4 | 5 | 4 | 1 | 15 | 93.33％ |
| Chloasma | 5 | 4 | 5 | 1 | 15 | 93.33％ |
| Sunburn | 4 | 5 | 5 | 1 | 15 | 93.33％ |
| Butterfly spot | 3 | 5 | 5 | 2 | 15 | 86.67％ |
| Black speck | 3 | 4 | 5 | 3 | 15 | 80.00％ |
Claims (5)
1. a Herba Blumeae Balsamiferae compositions for speckle dispelling, is characterized in that, is made up: Oleum Blumeae Balsamiferae 10 ~ 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 1 ~ 5 part, Flos Rosae Rugosae quintessence oil 1 ~ 5 part of following raw materials according by weight;
Described Oleum Blumeae Balsamiferae is prepared by following method: pulverized by Herba Blumeae Balsamiferae, under the condition of solid-liquid ratio 1: 10, at room temperature 2h is soaked with ether, be distilled to till solvent no longer flows out under the condition of Extracting temperature 40 DEG C, then be placed in the dry 30min of thermostatic drying chamber, thus obtain Oleum Blumeae Balsamiferae;
Described Herba Lysimachiae foenum-graeci quintessence oil is prepared by following method: get dry lavandula angustifolia, be first cut into the coarse fragments of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain lavandula angustifolia powder, then in described lavandula angustifolia powder, the Oleum Blumeae Balsamiferae of above-mentioned preparation is added as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is 20: 1, then the mixture of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 12g/min, extraction kettle pressure is 25Mpa, temperature is 40 DEG C, the pressure of adjustment separating still is 3Mpa, temperature is 40 DEG C, circulation is extracted and disengaging time is 3h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Herba Lysimachiae foenum-graeci quintessence oil is obtained,
Described Flos Rosae Rugosae quintessence oil is prepared by following method: get dry Flos Rosae Rugosae, be first cut into the fragment of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain Flos Rosae Rugosae powder, then in described Flos Rosae Rugosae powder, the Oleum Blumeae Balsamiferae of above-mentioned preparation is added as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is 25: 1, then the mixture of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 14g/min, extraction kettle pressure is 23Mpa, temperature is 42 DEG C, the pressure of adjustment separating still is 3.8Mpa, temperature is 43 DEG C, circulation is extracted and disengaging time is 5h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Flos Rosae Rugosae quintessence oil is obtained.
2. the Herba Blumeae Balsamiferae compositions of speckle dispelling according to claim 1, is characterized in that, by weight, and Oleum Blumeae Balsamiferae 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 5 parts, Flos Rosae Rugosae quintessence oil 5 parts.
3. the Herba Blumeae Balsamiferae compositions of speckle dispelling according to any one of claim 1 to 2, is characterized in that, described compositions is direct or use other cotton pads medium indirect application in facial skin.
4. Herba Blumeae Balsamiferae compositions is preparing the application in medicine for removing speckle, it is characterized in that, described compositions is made up of following raw materials according by weight: Oleum Blumeae Balsamiferae 10 ~ 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 1 ~ 5 part, Flos Rosae Rugosae quintessence oil 1 ~ 5 part;
Described Oleum Blumeae Balsamiferae is prepared by following method: pulverized by Herba Blumeae Balsamiferae, under the condition of solid-liquid ratio 1: 10, at room temperature 2h is soaked with ether, be distilled to till solvent no longer flows out under the condition of Extracting temperature 40 DEG C, then be placed in the dry 30min of thermostatic drying chamber, thus obtain Oleum Blumeae Balsamiferae;
Described Herba Lysimachiae foenum-graeci quintessence oil is prepared by following method: get dry lavandula angustifolia, be first cut into the coarse fragments of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain lavandula angustifolia powder, then in described lavandula angustifolia powder, the Oleum Blumeae Balsamiferae of above-mentioned preparation is added as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is 20: 1, then the mixture of described lavandula angustifolia powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 12g/min, extraction kettle pressure is 25Mpa, temperature is 40 DEG C, the pressure of adjustment separating still is 3Mpa, temperature is 40 DEG C, circulation is extracted and disengaging time is 3h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Herba Lysimachiae foenum-graeci quintessence oil is obtained,
Described Flos Rosae Rugosae quintessence oil is prepared by following method: get dry Flos Rosae Rugosae, be first cut into the fragment of 2-5mm with high-speed slice cutting machine, be then ground into 30 order fine powders with pulverizer, obtain Flos Rosae Rugosae powder, then in described Flos Rosae Rugosae powder, the Oleum Blumeae Balsamiferae of above-mentioned preparation is added as extraction auxiliary agent, stir and mix homogeneously, the weight ratio of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is 25: 1, then the mixture of described Flos Rosae Rugosae powder and described Oleum Blumeae Balsamiferae is added in the extraction kettle of supercritical carbon dioxide extraction device, close kettle cover, the speed of adjustment CO 2 fluid is 14g/min, extraction kettle pressure is 23Mpa, temperature is 42 DEG C, the pressure of adjustment separating still is 3.8Mpa, temperature is 43 DEG C, circulation is extracted and disengaging time is 5h, collect the product of releasing in separating still, through the sedimentation-type centrifuge separating treatment of 4000r/min, divide and remove bottom moisture and impurity, namely described Flos Rosae Rugosae quintessence oil is obtained.
5. application according to claim 4, is characterized in that, by weight, and Oleum Blumeae Balsamiferae 20 parts, Herba Lysimachiae foenum-graeci quintessence oil 5 parts, Flos Rosae Rugosae quintessence oil 5 parts.
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| CN201410382298.7A CN104095797B (en) | 2014-08-05 | 2014-08-05 | A kind of Herba Blumeae Balsamiferae compositions of speckle dispelling and application thereof |
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| CN201410382298.7A CN104095797B (en) | 2014-08-05 | 2014-08-05 | A kind of Herba Blumeae Balsamiferae compositions of speckle dispelling and application thereof |
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| CN104095797B true CN104095797B (en) | 2016-04-27 |
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| CN109350563B (en) * | 2018-12-28 | 2021-04-30 | 海南海药本草生物科技有限公司 | Composition containing borneol oil for removing freckles |
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| CN103830151A (en) * | 2014-03-25 | 2014-06-04 | 贵州利生香中药科技有限公司 | Application of blumea balsamifera oil in daily chemical product |
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| 艾纳香黄酮类化学成分研究进展;韦睿斌等;《广东药学院学报，》;20140228;第30卷(第1期);第123-127页 * |
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Effective date of registration: 20190505 Address after: 570105 Building D 343, Fuxing City, 32 Binhai Avenue, Longhua District, Haikou City, Hainan Province Patentee after: Hainan Ainaxiang Biotechnology Development Co., Ltd. Address before: 571737 Institute of Tropical Crop Varieties Resources, Chinese Academy of Tropical Agricultural Sciences, Baodao New Village, Danzhou City, Hainan Province Co-patentee before: Pang Yuxin Patentee before: Resources Institute of Tropical Crop Varieties of Chinese Academy of Tropical Agricultural Sciences |