CN105213225B - A kind of Anti-radiation facial cream containing blumea oil - Google Patents
A kind of Anti-radiation facial cream containing blumea oil Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
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Abstract
The invention belongs to daily cosmetics fields, specifically disclose a kind of Anti-radiation facial cream containing blumea oil, include each component of following weight percent：Oil phase formula 33.1 ~ 44.2%, water phase formula 46.5 ~ 66.35%, anti-radiation active substances blumea oil 0.5 ~ 9.0%, fragrance 0.05 ~ 0.3%.The present invention is using blumea oil as the anti-radiation active substances of face cream, it contains the bioactive substances such as L-Borneol, camphor, have the effects that anti-oxidant, anti-aging, inhibit B16 cell, enhance the capability of resistance to radiation of skin, blumea oil has good absorbability to ultraviolet light simultaneously, has certain sun-proof result；Blumea oil and oil phase formula, water phase formula and fragrance are formed into face cream according to a certain ratio, can be generated to face skin improves coarse, enhancing elasticity, radioresistance, reduces the effects that pigementation, and Blumea balsamifera infiltration is easier to skin absorption among face cream, to reach radiation-resistant purpose.It for computer family, mobile phone family and is exposed to for the crowd of ultraviolet light for a long time, is optimal selection.
Description
Technical field
The invention belongs to daily cosmetics fields, and in particular, to a kind of Anti-radiation facial cream containing blumea oil.
Background technology
Due to ultraviolet light irradiation, before computer, television set sitting, play mobile phones for a long time and ipad, contact radioactive substance
Equal various factors cause a variety of radiation " pollution " to human body.These radiation sources can lead to the disorder of human endocrine system, make
Skin metabolism is irregular, and computer is magnetic, and can build up some dusts and unclean air, influence skin quality, cause skin
Skin skin corium collapses, moisture-retaining capacity declines, has dry skin the problems such as aging, pigementation.Therefore, prevent radiation damage face skin
Skin becomes the topic of people's growing interest.Face cream is a most important step in basic skin care, and the active ingredient in face cream can be very
It is good by percutaneous absorption, improve the texture and the colour of skin uniformity of skin surface, keep skin more full of elasticity and careful.But now
Commercially available Anti-radiation facial cream type is seldom, and many face cream products can all add artificial color, fragrance and ore class drug（Such as
Heavy metal Hg etc.）, these ingredients may influence the metabolism of skin of face, be unfavorable for being used for a long time, and pregnant woman uses harm
Bigger.Therefore, it is badly in need of developing a kind of existing good using effect and novel Anti-radiation facial cream safe to use.
Blumea balsamiferaBlumea balsamifera(L.) DC. is the perennial wooden herbaceous plant that composite family Blumea balsamifera belongs to,
Alias Balsamiferou Blumea Herb, borneol Chinese mugwort, medicinal part are its fresh or dry aerial part.It is used as traditional national drug in south China
Usage history is long, has analgesia, promoting blood circulation, treatment traumatic injury, body beautification deodorization and other effects.Blumea balsamifera first recorded in《Book on Chinese herbal medicine picks up
It loses》, traumatic injury is controlled in external application, boil pain swells, eczema, dermatitis, hereafter《Kaibao Bencao》、《Compendium of Materia Medica》Deng all once recording.《Ridge
South is gathered medicinal herbs record》Described in Blumea balsamifera have " treating snakebite mouth does not conform to, and controls traumatic injury, pruitus " and other effects；Guangzhou army《It is common
Chinese herbal medicine handbook》" Blumea balsamifera fresh leaf mashes external application, or pan-fried washing affected part can treat traumatic injury, create furuncle carbuncle swells and skin for record
Skin itch ".In Li nationality mountain area, often with Blumea balsamifera blade progress infant to boil water and the daily bathing of adult, skin disease is prevented；With Chinese mugwort
Spiceleaf piece of receiving baking application burn, scald, weapons hinder skin, can be with analgesic antiphlogistic, preventing from scar after wound healing.Pharmacological evaluation
Studies have shown that blumea oil is rich in various bioactivators, such as L-Borneol, camphor, it is original with blumea oil extract
Cosmetics made of material then have the effects that anti-oxidant, anti-aging, inhibit B16 cell, while blumea oil is to ultraviolet light
With good absorbability, there is certain sun-proof result, can be generated to face skin improves coarse, enhancing elasticity, anti-spoke
Penetrate, reduce pigementation and other effects.Finding the Anti-radiation facial cream containing blumea oil by investigation, there is not been reported.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of Anti-radiation facial creams containing blumea oil, have safety
It is nontoxic, while radiation can effectively be isolated again, it protects skin not raying to damage, inhibits melanocyte activity, prevent color
The characteristics of spot generates.
Another object of the present invention is to provide the preparation methods of the above-mentioned Anti-radiation facial cream containing blumea oil.
The above-mentioned purpose of the present invention is achieved by the following technical programs.
A kind of Anti-radiation facial cream containing blumea oil, includes each component of following weight percent：Oil phase formula 33.1 ~
44.2%, water phase formula 46.5 ~ 66.35%, anti-radiation active substances blumea oil 0.5 ~ 9.0%, fragrance 0.05 ~ 0.3%.
The present invention contains the bioactivity such as L-Borneol, camphor using blumea oil as the anti-radiation active substances of face cream
Substance has the effects that anti-oxidant, anti-aging, inhibits B16 cell, enhances the capability of resistance to radiation of skin, while blumea oil
There is good absorbability to ultraviolet light, there is certain sun-proof result；According to a certain ratio by blumea oil and oil phase formula,
Water phase formula and fragrance form face cream, and can be generated to face skin improves coarse, enhancing elasticity, radioresistance, reduces pigementation
The effects that, and Blumea balsamifera infiltration is easier to skin absorption among face cream, to reach radiation-resistant purpose.
Preferably, the component of the oil phase formula and water phase formula forms according to the following percentages by weight：
Oil phase formula：Stearic acid 5 ~ 6.5%, olive oil 8 ~ 10%, PEG-1500 4 ~ 6%, sodium hyaluronate 1.0 ~ 2.5%, cetanol
6.5 ~ 7.5%, isopropyl palmitate 5 ~ 7%, saualane 3.5 ~ 4.5%, nipalgin 0.1 ~ 0.2%；
Water phase formula：Triethanolamine 1.0 ~ 2.0%, glycerine 8 ~ 10%, deionized water 34.5 ~ 57.35%.
Preferably, the blumea oil accounts for the 1 ~ 8% of face cream total weight.
Preferably, each component forms according to the following percentages by weight：
Oil phase formula：Stearic acid 6%, olive oil 8.5%, PEG-1500 4%, sodium hyaluronate 2.5%, cetanol 7.5%, palmitic acid
Isopropyl ester 6.5%, saualane 4%, nipalgin 0.2%；
Water phase formula：Triethanolamine 2%, glycerine 9%, deionized water 45.6%；
Anti-radiation active substances：Blumea oil 4%；
Fragrance：Flos micheliae Albae essence 0.2%.
The present invention also provides a kind of preparation methods of above-mentioned Anti-radiation facial cream, include the following steps：
S1. oil phase formula is prepared：Stearic acid, cetanol during oil phase is formulated and PEG-1500 mixing, are dissolved in olive
In oil, fragrance Flos micheliae Albae essence consolute is added at homogeneous in heating, and oil phase formula initial material is made, spare；
S2. water phase formula is prepared：Triethanolamine, glycerine during water phase is formulated and deionized water mixing, are heated, dissolving
At homogeneous, water phase formula initial material is made, it is spare；
S3. prepared by water oil mixture：By S2 water phases be formulated initial material half under constant temperature 1000 ~ 2500 r/min
Stirring, and it is slowly added to the oil phase formula initial material of S1,15 ~ 20 min of reaction obtain water oil mixture, spare；
S4. prepared by oil mixing with water material：Sodium hyaluronate, isopropyl palmitate, saualane and nipalgin during oil phase is formulated mix
After conjunction, heating carries out consolute, and another meromict of initial material, 1000 r/min stirrings, emulsification, homogeneous are then formulated with S2 water phases
Oil mixing with water material is obtained, it is spare；
S5. it mixes：By oil mixing with water material mixing made from water oil mixture made from S3 and S4, blumea oil is added, mixes
It is even, degassing is vacuumized, waits for that temperature is down to room temperature to get the Anti-radiation facial cream containing blumea oil.
Preferably, the condition heated described in S1 and S4 is to be heated to 75 ~ 85 DEG C with the heating rate of 5 ~ 8 DEG C/min；S2
The condition of the heating is to be heated to 75 ~ 90 DEG C with the heating rate of 8 ~ 12 DEG C/min.
Preferably, constant temperature described in S3 is 90 ± 1 DEG C.
Preferably, the rotating speed stirred described in S3 is 1000 r/min.
Preferably, the time of homogeneous described in S4 is 5 ~ 10 min.
Preferably, the method for addition blumea oil described in S5 is：When liquid to be mixed is cooled to 50 ~ 60 DEG C, half is added
Anti-radiation active substances blumea oil, and 5 ~ 10 min of homogeneous under 0.05 ~ 0.25 Mpa pressure；When temperature is down to 30 ~ 40 DEG C
When, then add the other half blumea oil, and temperature is risen to 50 ~ 60 DEG C, under 0.05 ~ 0.25 Mpa pressure again homogeneous 5 ~
10 min。
Compared with prior art, the advantageous effect of technical solution of the present invention is：The present invention is using blumea oil as the anti-of face cream
Radiation activated substance has anti-oxidant, anti-aging, melanin is inhibited to close containing bioactive substances such as L-Borneol, camphors
At the effects that, enhance the capability of resistance to radiation of skin, while blumea oil has good absorbability to ultraviolet light, have certain
Sun-proof result, can to face skin generate improve it is coarse, enhancing elasticity, radioresistance, reduce pigementation the effects that, permeate in
It is easier to skin absorption among face cream, to reach radiation-resistant purpose, is exposed to for computer family, mobile phone family and for a long time
It is optimal selection for the crowd of ultraviolet light.
Specific implementation mode
The present invention is described in further details with reference to specific embodiment, but embodiment the present invention is not done it is any
The restriction of form.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagent, methods
And equipment.
Embodiment 1
It is by oil phase formula, water phase formula, radioresistance the present embodiment provides a kind of Anti-radiation facial cream containing blumea oil
Four kinds of components of active material and fragrance are prepared, and each component component forms according to the following percentages by weight：
Oil phase formula：Stearic acid 6%, olive oil 8.5%, PEG-1500 4%, sodium hyaluronate 2.5%, cetanol 7.5%, palmitic acid
Isopropyl ester 6.5%, saualane 4%, nipalgin 0.2%；
Water phase formula：Triethanolamine 2%, glycerine 9%, deionized water 45.6%；
Anti-radiation active substances：Blumea oil 4%；
Fragrance：Flos micheliae Albae essence 0.2%.
The Anti-radiation facial cream chooses the raw material for standby of each component respectively according to above-mentioned parts by weight, and preparation method includes
Following steps：
S1. oil phase formula is prepared：Stearic acid starting material, cetanol and PEG-1500 during spare oil phase is formulated mix,
It is dissolved in olive oil, 85 DEG C is heated to the heating rate of 8 DEG C/min, fragrance Flos micheliae Albae essence is added and is mixed
It is molten, oil phase formula initial material is made, it is spare；
S2. water phase formula is prepared：Raw material triethanolamine, glycerine and deionized water during spare water phase is formulated mix,
90 DEG C are heated with the heating rate of 8 DEG C/min, is dissolved, water phase formula initial material is become, it is spare；
S3. water oil mixture is prepared：The half that spare S2 water phases are first formulated to initial material is added in four-necked bottle, and constant temperature exists
90 DEG C or so, magnetic force heating stirrer is started, control stir speed (S.S.) is 1000 r/min, is slowly added to oil phase, reaction 15
Min stops heating, obtains water oil mixture, spare；
S4. oil mixing with water material is prepared：Raw material sodium hyaluronate, isopropyl palmitate during spare oil phase is formulated, spiny dogfish
After alkane, nipalgin mixing, be heated to 85 DEG C with the heating rate of 8 DEG C/min, carry out consolute, then with S2 water phase formulas
Another meromict of initial material is stirred under the rotating speed of 1000 r/min, is emulsified, 10 min of homogeneous, obtains oil mixing with water material, spare；
S5. it mixes：By oil mixing with water material mixing made from water oil mixture made from S3 and S4, stirring is cooled to 50 DEG C
When, the spare anti-radiation active substances blumea oil of addition half, and 10 min of homogeneous under 0.15 Mpa pressure；When temperature drops
When to 35 DEG C, then the other half blumea oil is added, and temperature is risen to 60 DEG C, homogeneous 10 again under 0.15 Mpa pressure
min；Then, it is sufficiently stirred, starts vacuum pump, vacuumize degassing, wait for that temperature drops to room temperature to get the anti-spoke containing blumea oil
Penetrate face cream.
It is shown in Table 1 and table respectively by the radioresistance effect of face cream made of above-mentioned formula and preparation method and the property of face cream
2。
Embodiment 2
The Anti-radiation facial cream containing blumea oil of the present embodiment is by oil phase formula, water phase formula, radioresistance active matter
Four kinds of components of matter and fragrance are prepared, and each component is made of following raw material by weight：
Oil phase formula：Stearic acid 5.5%, olive oil 9%, PEG-1500 5%, sodium hyaluronate 2%, cetanol 7%, palmitic acid isopropyl
Ester 6%, saualane 4%, nipalgin 0.2%；
Water phase formula：Triethanolamine 1.5%, glycerine 9%, deionized water 41.6%；
Anti-radiation active substances：Blumea oil 9%；
Fragrance：Flos micheliae Albae essence 0.2%.
Preparation method is same as Example 1.
It is shown in Table 1 and table respectively by the radioresistance effect of face cream made of above-mentioned formula and preparation method and the property of face cream
2。
Embodiment 3
The formula of the present embodiment and the Anti-radiation facial cream containing blumea oil described in embodiment 1 is essentially identical, difference
It is that the content of anti-radiation active substances blumea oil is different, specifically, the formula of this comparative example Anti-radiation facial cream is as follows：
Oil phase formula：Stearic acid 6%, olive oil 8.5%, PEG-1500 4%, sodium hyaluronate 2.5%, cetanol 7.5%, palmitic acid
Isopropyl ester 6.5%, saualane 4%, nipalgin 0.2%；
Water phase formula：Triethanolamine 2%, glycerine 9%, deionized water 48.8%；
Anti-radiation active substances：Blumea oil 0.8%；
Fragrance：Flos micheliae Albae essence 0.2%.
Preparation method is same as Example 1.
It is shown in Table 1 and table respectively by the radioresistance effect of face cream made of above-mentioned formula and preparation method and the property of face cream
2。
Comparative example 1
This comparative example and the formula of the Anti-radiation facial cream containing blumea oil described in embodiment 1 are essentially identical, difference
It is that the content of anti-radiation active substances blumea oil is different, specifically, the formula of this comparative example Anti-radiation facial cream is as follows：
Oil phase formula：Stearic acid 6%, olive oil 8.5%, PEG-1500 4%, sodium hyaluronate 2.5%, cetanol 7.5%, palmitic acid
Isopropyl ester 6.5%, saualane 4%, nipalgin 0.2%；
Water phase formula：Triethanolamine 2%, glycerine 9%, deionized water 34.6%；
Anti-radiation active substances：Blumea oil 15%；
Fragrance：Flos micheliae Albae essence 0.2%.
Preparation method is same as Example 1.
It is shown in Table 1 He respectively by the radioresistance effect of face cream made of above-mentioned formula and preparation method and/or the property of face cream
Table 2.
Comparative example 2
The anti-radiation active substances blumea oil of this comparative example and the Anti-radiation facial cream containing blumea oil described in embodiment 1
Content it is identical, other formula compositions and content are different, and specifically, the formula of this comparative example Anti-radiation facial cream is as follows：
Oil phase formula：Stearic acid 2%, tea oil 8.5%, PEG-200 4%, cetanol 7.5%, isopropyl palmitate 6.5%, angle
Shark alkane 4%, nipalgin 0.2%；Without sodium hyaluronate, oil phase formulation content is 32.7%, not within the scope of the present invention；
Water phase formula：Triethanolamine 2%, glycerine 9%, deionized water 52.1%；
Anti-radiation active substances：Blumea oil 4%；
Fragrance：Camellia extrait 0.2%.
It is shown in Table 1 He respectively by the radioresistance effect of face cream made of above-mentioned formula and preparation method and/or the property of face cream
Table 2.
The radioresistance effect of face cream of the table 1 containing blumea oil compares
The physicochemical property of face cream of the table 2 containing blumea oil compares
Claims (9)
1. a kind of Anti-radiation facial cream containing blumea oil, which is characterized in that include each component of following weight percent：Oil phase
Formula 33.1~44.2%, water phase formula 46.5~66.35%, anti-radiation active substances blumea oil 0.5~9.0%, fragrance 0.05
~0.3%；
Wherein, the component of the oil phase formula and water phase formula forms according to the following percentages by weight：
Oil phase formula：Stearic acid 5~6.5%, olive oil 8~10%, PEG-1500 4~6%, sodium hyaluronate 1.0~2.5%, cetanol
6.5~7.5%, isopropyl palmitate 5~7%, saualane 3.5~4.5%, nipalgin 0.1~0.2%；
Water phase formula：Triethanolamine 1.0~2.0%, glycerine 8~10%, deionized water 34.5~57.35%.
2. Anti-radiation facial cream according to claim 1, which is characterized in that the blumea oil account for face cream total weight 1~
8%。
3. Anti-radiation facial cream according to claim 1, which is characterized in that each component forms according to the following percentages by weight：
Oil phase formula：Stearic acid 6%, olive oil 8.5%, PEG-1500 4%, sodium hyaluronate 2.5%, cetanol 7.5%, palmitic acid isopropyl
Ester 6.5%, saualane 4%, nipalgin 0.2%；
Water phase formula：Triethanolamine 2%, glycerine 9%, deionized water 45.6%；
Anti-radiation active substances：Blumea oil 4%；
Fragrance：Flos micheliae Albae essence 0.2%.
4. the preparation method of Anti-radiation facial cream described in a kind of claims 1 to 3, which is characterized in that include the following steps：
S1. oil phase formula is prepared：Stearic acid, cetanol during oil phase is formulated and PEG-1500 mixing, are dissolved in olive oil
In, fragrance Flos micheliae Albae essence consolute is added at homogeneous in heating, and oil phase formula initial material is made, spare；
S2. water phase formula is prepared：Triethanolamine, glycerine and deionized water mixing, heating during water phase is formulated are dissolved into
Water phase formula initial material is made in phase, spare；
S3. prepared by water oil mixture：By the half of S2 water phases formula initial material, 1000~2500 r/min are stirred under constant temperature
It mixes, and is slowly added to the oil phase formula initial material of S1,15~20 min of reaction obtain water oil mixture, spare；
S4. prepared by oil mixing with water material：Sodium hyaluronate, isopropyl palmitate, saualane during oil phase is formulated and nipalgin mixing
Afterwards, it heats, carries out consolute, another meromict of initial material is then formulated with S2 water phases, 1000 r/min stirrings, emulsification, homogeneous obtain
Oil mixing with water material, it is spare；
S5. it mixes：By oil mixing with water material mixing made from water oil mixture made from S3 and S4, it is added blumea oil, mixing,
Degassing is vacuumized, waits for that temperature is down to room temperature to get the Anti-radiation facial cream containing blumea oil.
5. preparation method according to claim 4, which is characterized in that the condition heated described in S1 and S4 be with 5~8 DEG C/
The heating rate of min is heated to 75~85 DEG C；The condition heated described in S2 is to be heated to the heating rate of 8~12 DEG C/min
75~90 DEG C.
6. preparation method according to claim 4, which is characterized in that constant temperature described in S3 is 90 ± 1 DEG C.
7. preparation method according to claim 4, which is characterized in that the rotating speed stirred described in S3 is 1000 r/min.
8. preparation method according to claim 4, which is characterized in that the time of homogeneous described in S4 is 5~10 min.
9. preparation method according to claim 4, which is characterized in that described in S5 be added blumea oil method be：It waits mixing
When conjunction liquid is cooled to 50~60 DEG C, the anti-radiation active substances blumea oil of half is added, and in 0.05~0.25 Mpa pressure
Lower 5~10 min of homogeneous；When temperature is down to 30~40 DEG C, then the other half blumea oil is added, and temperature is risen to 50~60
DEG C, 5~10 min of homogeneous again under 0.05~0.25 Mpa pressure.
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| CN107157911A (en) * | 2017-07-06 | 2017-09-15 | 天津杞源堂生物工程有限公司 | A kind of after-sun fermentation Chinese wolfberry fruit liquid level film and preparation method thereof |
| CN108078881A (en) * | 2017-12-29 | 2018-05-29 | 广州宸极生物科技有限公司 | A kind of skin repair liquid |
| CN108379130A (en) * | 2018-05-19 | 2018-08-10 | 无域生物科技（广州）有限公司 | A kind of moisturizing and Sin-care composition and preparation method thereof |
| CN110974861B (en) * | 2019-12-24 | 2022-02-01 | 贵州大学 | Blumea balsamifera oil liposome |
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|---|---|---|---|---|
| CN102961282A (en) * | 2012-11-19 | 2013-03-13 | 中国热带农业科学院热带作物品种资源研究所 | Composition with penetration enhancing effect as well as preparation method and application thereof |
| CN103830151A (en) * | 2014-03-25 | 2014-06-04 | 贵州利生香中药科技有限公司 | Application of blumea balsamifera oil in daily chemical product |
| CN104095797A (en) * | 2014-08-05 | 2014-10-15 | 中国热带农业科学院热带作物品种资源研究所 | Blumea balsamifera composite with freckle removing effect and application thereof |
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| CN105213225A (en) | 2016-01-06 |
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Effective date of registration: 20190415 Address after: 570105 Building D 343, Fuxing City, 32 Binhai Avenue, Longhua District, Haikou City, Hainan Province Patentee after: Hainan Ainaxiang Biotechnology Development Co., Ltd. Address before: 571737 Institute of Tropical Crop Varieties Resources, Chinese Academy of Tropical Agricultural Sciences, Danzhou City, Sanya City, Hainan Province Patentee before: Resources Institute of Tropical Crop Varieties of Chinese Academy of Tropical Agricultural Sciences |