CN106727847A - A kind of antipruritic ointment containing wormwood extract and preparation method thereof - Google Patents
A kind of antipruritic ointment containing wormwood extract and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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Abstract
The invention belongs to field of medicaments, and in particular to a kind of antipruritic ointment containing wormwood extract and preparation method thereof.The antipruritic ointment containing wormwood extract includes the preparing raw material of following weight portion：500 ~ 650 parts of 50 ~ 60 parts of wormwood extract, 20 ~ 25 parts of leaf of Moringa, 25 ~ 30 parts of Honeysuckle flower, 40 ~ 60 parts of glycerine, 130 ~ 140 parts of atoleine, 110 ~ 120 parts of stearic acid, 8 ~ 10 parts of triethanolamine and water.Above raw material by the gentle muting sensitive of antipruritic ointment containing wormwood extract obtained in preparation method of the present invention, can Quick itch stopping anti-inflammatory, effective bactericidal can be used for treatment children's pruritus dermatopathy.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of antipruritic ointment containing wormwood extract and preparation method thereof.
Background technology
Children's pruritus dermatopathy mainly has prickly heat, summer dermatitis, eczema, measles etc., is UDC, frequently-occurring disease,
The numerous children's of serious harm is healthy.Treatment to children's pruritus dermatopathy at present is typically with antiallergy chemical drugs
Thing, take the modes such as Chinese medicine or external washout with traditional Chinese herbs.The toxic and side effect of chemicals is big, and potential danger is more, is not appropriate for children's mistake
Take more；Take the problem that the mode of Chinese medicine or external washout with traditional Chinese herbs is present also a lot, such as Chinese medicine takes that compliance is poor, and consumption is inaccurate
The curative effect being really likely to result in is slow or adverse reaction is larger；External washout with traditional Chinese herbs is cumbersome, DeGrain etc..Meanwhile, children's
Skin is more tender and lovely, easy infection and stimulation by bacterium, easy allergy, and immunity is relatively low etc., and institute is for treatment children
The necessary muting sensitive of the medicine of pruritus dermatopathy is gentle, not only to possess antipruritic, anti-inflammatory effect, while should also possess sterilized, suppression
The effect of bacterium.
Having antipruritic, anti-inflammatory effect ointment species in the market has a lot, but applies to the little of children, China
The B of patent CN 101167811 disclose it is a kind of with anti-inflammatory, antipruritic, bactericidal action external preparation, it is by honeysuckle, summer cypress
Son, the Radix Astragali, Asian puccoon, the root bark of shaggy-fruited dittany, peppermint, borneol, cicada slough, talcum, Radix Glycyrrhizae and honey are prepared from, and it can be used as treatment children's scabies
The medicine of itching skin disease, but the external preparation flavour of a drug are numerous, and complicated component is unfavorable for popularization and application.
Therefore, it is necessary to study a kind of suitable for children, energy Quick itch stopping, anti-inflammatory, bactericidal, and have no toxic side effect
The antipruritic ointment of pure Chinese medicine.
The content of the invention
In view of the shortcomings of the prior art, it is an object of the invention to provide a kind of antipruritic ointment containing wormwood extract and
Its preparation method, should the gentle muting sensitive of antipruritic ointment containing wormwood extract, children be applicable, can Quick itch stopping anti-inflammatory, effectively kill
Bacterium is antibacterial.
To achieve these goals, technical scheme is as follows：
A kind of antipruritic ointment containing wormwood extract, including following weight portion preparing raw material：50 ~ 60 parts of wormwood extract,
20 ~ 25 parts of leaf of Moringa, 25 ~ 30 parts of Honeysuckle flower, 40 ~ 60 parts of glycerine, 130 ~ 140 parts of atoleine, stearic acid 110 ~ 120
500 ~ 650 parts of part, 8 ~ 10 parts of triethanolamine and water.
Used as the preferred embodiment of the present invention, the antipruritic ointment containing wormwood extract includes following weight portion
Preparing raw material：It is 58 parts of wormwood extract, 22 parts of leaf of Moringa, 26 parts of Honeysuckle flower, 50 parts of glycerine, 135 parts of atoleine, hard
586 parts of 114 parts of resin acid, 9 parts of triethanolamine and water.
Further, the wormwood extract is made up of wormwood volatile oil and wormwood alcohol extract；The wormwood volatile oil
Preparation method comprises the following steps：Fresh wormwood is taken, is placed in supercritical carbon dioxide extraction apparatus after rubbing, regulate and control titanium dioxide
Carbon flow is 16 ~ 20L/h, and extracting pressure is 15 ~ 20MPa, and extraction temperature is 30 ~ 35 DEG C, and extraction time is 1.5 ~ 2h, decompression point
From wormwood volatile oil is obtained, retain wormwood residue；
The preparation method of the wormwood alcohol extract comprises the following steps：The wormwood residue is taken, the body of 4 ~ 6 times of residue weight is added
Fraction is 60 ~ 70% ethanol solution, is extracted at 60 ~ 70 DEG C 2 ~ 3 times, and 2 ~ 3h is extracted every time, and filtering merges extract solution,
It is 1.25 ~ 1.30 medicinal extract to be concentrated under reduced pressure into relative density at 60 DEG C, and wormwood alcohol extract is obtained.
Further, the weight ratio of the wormwood volatile oil and wormwood alcohol extract is（0.2~0.6）: 1 ；Preferably
0.4 : 1.The preparation method of the above-mentioned antipruritic ointment containing wormwood extract, comprises the following steps：
S1, take fresh leaf of Moringa, rub, add the volume fraction of 6 ~ 8 times of its weight for 70 ~ 80% ethanol solution, microwave carries
Take 15 ~ 25min, microwave power is 600 ~ 800w, Extracting temperature is 45 ~ 55 DEG C, filtering, extract solution be concentrated under reduced pressure into 60 DEG C at phase
It is 1.25 ~ 1.30 medicinal extract to density, moringa oleifera leaf extractive is obtained；
S2, take fresh Honeysuckle flower, rub, add the volume fraction of 5 ~ 7 times of its weight for 60 ~ 70% ethanol solution, microwave carries
Take 15 ~ 25min, microwave power is 600 ~ 800w, Extracting temperature is 45 ~ 55 DEG C, filtering, extract solution be concentrated under reduced pressure into 60 DEG C at phase
It is 1.25 ~ 1.30 medicinal extract to density, Lonicera confusa extract is obtained；
S3, take glycerine, atoleine, stearic acid, triethanolamine and water and be placed in container, heating for dissolving simultaneously stirs, then
Natural condensation adds wormwood extract, moringa oleifera leaf extractive and Lonicera confusa extract to 40 ~ 45 DEG C, stirs, and obtains final product.
Antipruritic ointment containing wormwood extract of the invention contains wormwood extract, moringa oleifera leaf extractive and Honeysuckle flower and extracts
Three kinds of natural plant active components of thing.Wherein, to contain volatile oil, flavonoids, folium eucalypti alkanes, triterpenes etc. various for wormwood extract
Composition, with the multiple efficacies such as antibacterial, antiviral, antiallergy.Leaf of Moringa is rich in several mineral materials, vitamin, amino acid, antioxygen
Plain and naturally anti-scorching body, with hypoglycemic, lipid-loweringing, step-down, antitumor, anti-oxidant, defaecation, diuresis, expelling parasite, the work(such as improves the health care of sleep
Effect.Honeysuckle flower contains the Multiple components such as chlorogenic acid, volatile oil, flavonoids, triterpenoid saponin, the effects such as with antibacterial, anti-inflammatory.More than
Component is combined with glycerine, atoleine, stearic acid, triethanolamine and water and is made the antipruritic ointment containing wormwood extract of the invention
Gentle muting sensitive, children are applicable, can Quick itch stopping anti-inflammatory, effective bactericidal.Clinical test proves that the present invention is extracted containing wormwood
The antipruritic ointment of thing can be used as the external used medicine for the treatment of children's pruritus dermatopathy.
Therefore, compared with prior art, advantage of the invention is that：
（1）The invention provides a kind of new antipruritic ointment containing wormwood extract, it contains wormwood volatile oil, wormwood alcohol extracting
Various natural plant active components such as thing, moringa oleifera leaf extractive and Lonicera confusa extract, are a kind of pure plant preparations, effectively
Bactericidal, also acts on antipruritic, anti-inflammatory etc., lasting medicine stabilization, and gentle muting sensitive can be used to treat the pruritic skin of children
Disease, it is evident in efficacy, have no toxic side effect, and inventive formulation is simple, cost of material is low.
（2）The of the invention antipruritic ointment containing wormwood extract is prepared by waving for supercritical carbon dioxide extracting wormwood
Hair oil, recycles wormwood residue to carry out alcohol extracting, obtains wormwood alcohol extract；Using Microwave Extraction leaf of Moringa and Honeysuckle flower activity into
Point；Preparation technology of the present invention is fully extracted the active ingredient in raw material, maximally utilizes raw material value, and preparation technology is steady
Fixed, condition is controllable, can be applicable.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the present invention is not limited only to following examples.
The scope of the present invention is interior or is not departing from present disclosure, spirit and scope, and wormwood extraction is contained to of the present invention
The antipruritic ointment of thing is suitably modified, is replaced effect identical component, is to those skilled in the art apparent
, they are considered as being included within the scope of the present invention.
Embodiment 1, the antipruritic ointment containing wormwood extract of the invention and its prepare the present embodiment and contain wormwood extract
Antipruritic ointment be prepared from by the raw material of following weight portion：58 parts of wormwood extract, 22 parts of leaf of Moringa, 26 parts of Honeysuckle flower,
50 parts of glycerine, 135 parts of atoleine, 114 parts of stearic acid, 586 parts of wormwood extracts of 9 parts of triethanolamine and water by
Wormwood volatile oil and wormwood alcohol extract are constituted, and the weight ratio of the wormwood volatile oil and wormwood alcohol extract is 0.4: 1 ；
The preparation method of the wormwood volatile oil comprises the following steps：Fresh wormwood is taken, supercritical carbon dioxide is placed in after rubbing
In extraction equipment, regulation and control carbon dioxide flow is 18L/h, and extracting pressure is 20MPa, and extraction temperature is 32 DEG C, and extraction time is
1.5h, decompression separation is obtained wormwood volatile oil, retains wormwood residue；
The preparation method of the wormwood alcohol extract comprises the following steps：The wormwood residue is taken, the body of 5 times of residue weight is added
Fraction is 65% ethanol solution, is extracted 3 times at 65 DEG C, and 2h is extracted every time, and filtering merges extract solution, is concentrated under reduced pressure into
Relative density is 1.25 medicinal extract at 60 DEG C, and wormwood alcohol extract is obtained.
The present embodiment contains the preparation method of the antipruritic ointment of wormwood extract：
S1, fresh leaf of Moringa is taken, rubbed, the volume fraction for adding 7 times of its weight is 75% ethanol solution, Microwave Extraction
20min, microwave power is 800w, and Extracting temperature is 50 DEG C, filtering, and relative density is 1.25 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained moringa oleifera leaf extractive；
S2, fresh Honeysuckle flower is taken, rubbed, the volume fraction for adding 6 times of its weight is 65% ethanol solution, Microwave Extraction
20min, microwave power is 800w, and Extracting temperature is 50 DEG C, filtering, and relative density is 1.25 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained Lonicera confusa extract；
S3, take glycerine, atoleine, stearic acid, triethanolamine and water and be placed in container, heating for dissolving simultaneously stirs, then
Natural condensation adds wormwood extract, moringa oleifera leaf extractive and Lonicera confusa extract to 40 DEG C, stirs, and obtains final product.
Embodiment 2, the antipruritic ointment containing wormwood extract of the invention and its prepare the present embodiment and contain wormwood extract
Antipruritic ointment be prepared from by the raw material of following weight portion：50 parts of wormwood extract, 25 parts of leaf of Moringa, 25 parts of Honeysuckle flower,
600 parts of 40 parts of glycerine, 140 parts of atoleine, 110 parts of stearic acid, 10 parts of triethanolamine and water.
The wormwood extract is made up of wormwood volatile oil and wormwood alcohol extract, the wormwood volatile oil and wormwood alcohol extract
Weight ratio be 0.2: 1 ；The preparation method of the wormwood volatile oil comprises the following steps：Fresh wormwood is taken, after rubbing
It is placed in supercritical carbon dioxide extraction apparatus, regulation and control carbon dioxide flow is 16L/h, and extracting pressure is 20MPa, extraction temperature
It it is 35 DEG C, extraction time is 2h, decompression separation is obtained wormwood volatile oil, retains wormwood residue；
The preparation method of the wormwood alcohol extract comprises the following steps：The wormwood residue is taken, the body of 4 times of residue weight is added
Fraction is 70% ethanol solution, is extracted 2 times at 60 DEG C, and 3h is extracted every time, and filtering merges extract solution, is concentrated under reduced pressure into
Relative density is 1.30 medicinal extract at 60 DEG C, and wormwood alcohol extract is obtained.
The present embodiment contains the preparation method of the antipruritic ointment of wormwood extract：
S1, fresh leaf of Moringa is taken, rubbed, the volume fraction for adding 6 times of its weight is 80% ethanol solution, Microwave Extraction
15min, microwave power is 600w, and Extracting temperature is 45 DEG C, filtering, and relative density is 1.30 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained moringa oleifera leaf extractive；
S2, fresh Honeysuckle flower is taken, rubbed, the volume fraction for adding 5 times of its weight is 70% ethanol solution, Microwave Extraction
15min, microwave power is 800w, and Extracting temperature is 55 DEG C, filtering, and relative density is 1.30 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained Lonicera confusa extract；
S3, take glycerine, atoleine, stearic acid, triethanolamine and water and be placed in container, heating for dissolving simultaneously stirs, then
Natural condensation adds wormwood extract, moringa oleifera leaf extractive and Lonicera confusa extract to 45 DEG C, stirs, and obtains final product.
Embodiment 3, the antipruritic ointment containing wormwood extract of the invention and its preparation
The antipruritic ointment that the present embodiment contains wormwood extract is prepared from by the raw material of following weight portion：Wormwood extract 60
Part, 20 parts of leaf of Moringa, 30 parts of Honeysuckle flower, 60 parts of glycerine, 130 parts of atoleine, 120 parts of stearic acid, 8 parts of triethanolamine
With 572 parts of water.
The wormwood extract is made up of wormwood volatile oil and wormwood alcohol extract, the wormwood volatile oil and wormwood alcohol extract
Weight ratio be 0.6: 1 ；
The preparation method of the wormwood volatile oil comprises the following steps：Fresh wormwood is taken, supercritical carbon dioxide is placed in after rubbing
In extraction equipment, regulation and control carbon dioxide flow is 20L/h, and extracting pressure is 15MPa, and extraction temperature is 30 DEG C, and extraction time is
1.5h, decompression separation is obtained wormwood volatile oil, retains wormwood residue；
The preparation method of the wormwood alcohol extract comprises the following steps：The wormwood residue is taken, the body of 6 times of residue weight is added
Fraction is 60% ethanol solution, is extracted 3 times at 70 DEG C, and 2h is extracted every time, and filtering merges extract solution, is concentrated under reduced pressure into
Relative density is 1.25 medicinal extract at 60 DEG C, and wormwood alcohol extract is obtained.
The present embodiment contains the preparation method of the antipruritic ointment of wormwood extract：
S1, fresh leaf of Moringa is taken, rubbed, the volume fraction for adding 7 times of its weight is 70% ethanol solution, Microwave Extraction
25min, microwave power is 800w, and Extracting temperature is 55 DEG C, filtering, and relative density is 1.25 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained moringa oleifera leaf extractive；
S2, fresh Honeysuckle flower is taken, rubbed, the volume fraction for adding 7 times of its weight is 60% ethanol solution, Microwave Extraction
25min, microwave power is 600w, and Extracting temperature is 45 DEG C, filtering, and relative density is 1.25 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained Lonicera confusa extract；
S3, take glycerine, atoleine, stearic acid, triethanolamine and water and be placed in container, heating for dissolving simultaneously stirs, then
Natural condensation adds wormwood extract, moringa oleifera leaf extractive and Lonicera confusa extract to 40 DEG C, stirs, and obtains final product.
Comparative example one
This comparative example from unlike embodiment 1：The wormwood extract is wormwood alcohol extract, its preparation method：Take fresh
Wormwood is rubbed, and adds 5 times of wormwood weight, the ethanol solution that volume fraction is 65%, is extracted 3 times at 65 DEG C, is extracted every time
2h, filtering merges extract solution, is concentrated under reduced pressure into the medicinal extract that relative density at 60 DEG C is 1.25, and wormwood extract is obtained.Other with
Embodiment 1 is identical.
Comparative example two
The antipruritic ointment that this comparative example contains wormwood extract is prepared from by the raw material of following weight portion：Wormwood extract 58
Part, 26 parts of Honeysuckle flower, 50 parts of glycerine, 135 parts of atoleine, 114 parts of stearic acid, 9 parts of triethanolamine and 586 parts of water.
The wormwood extract is made up of wormwood volatile oil and wormwood alcohol extract, the wormwood volatile oil and wormwood alcohol extract
Weight ratio be 0.4: 1 ；The preparation method of the wormwood volatile oil comprises the following steps：Fresh wormwood is taken, is placed in after rubbing
In supercritical carbon dioxide extraction apparatus, regulation and control carbon dioxide flow is 18L/h, and extracting pressure is 20MPa, and extraction temperature is 32
DEG C, extraction time is 1.5h, and decompression separation is obtained wormwood volatile oil, retains wormwood residue；The preparation of the wormwood alcohol extract
Method comprises the following steps：The wormwood residue is taken, the volume fraction for adding 5 times of residue weight is 65% ethanol solution,
Extracted 3 times at 65 DEG C, 2h is extracted every time, filtering merges extract solution, is concentrated under reduced pressure into the leaching that relative density at 60 DEG C is 1.25
Cream, is obtained wormwood alcohol extract.
The present embodiment contains the preparation method of the antipruritic ointment of wormwood extract：
S1, fresh Honeysuckle flower is taken, rubbed, the volume fraction for adding 6 times of its weight is 65% ethanol solution, Microwave Extraction
20min, microwave power is 800w, and Extracting temperature is 50 DEG C, filtering, and relative density is 1.25 at extract solution is concentrated under reduced pressure into 60 DEG C
Medicinal extract, be obtained Lonicera confusa extract；
S2, take glycerine, atoleine, stearic acid, triethanolamine and water and be placed in container, heating for dissolving simultaneously stirs, then
Natural condensation adds wormwood extract and Lonicera confusa extract to 40 DEG C, stirs, and obtains final product.
The antiinflammatory action of test example one, the antipruritic ointment containing wormwood extract of the invention
First, material and method
1st, animal：One-level ICR mouse 60,20 ~ 22g of body weight, male and female half and half；
2nd, medicine：Ointment is made according to the embodiment of the present invention 1 ~ 3, the raw material of comparative example one, two and method；
3rd, animal packet：Animal is randomly divided into 6 groups, every group 10：
Control group：Ointment base-material 2.0gkg-1；
1 group of ointment：Ointment 2.0gkg-1 obtained in embodiment 1；
2 groups of ointment：Ointment 2.0gkg-1 obtained in embodiment 2；
3 groups of ointment：Ointment 2.0gkg-1 obtained in embodiment 3；
4 groups of ointment：Ointment 2.0gkg-1 obtained in comparative example one；
5 groups of ointment：Ointment 2.0gkg-1 obtained in comparative example two.
4th, experimental technique：Experimental day, by each group dosage in animal auris dextra（The positive and negative both sides of auricle）Coating, after medication
60min, medicine is cleaned with dry cotton ball, in auris dextra（The positive and negative both sides of auricle）Drop coating paraxylene, 30ul/, while applying again
Medicine once, after 15min takes off neck and puts to death animal, cuts two ears, and two ears are broken into disk with diameter 0.8cm card punch, weighs, right
Ear subtracts left ear weight difference for swelling, the difference between comparative drug group and control group.
The above is only the preferred embodiment of the present invention, it is noted that it is right that above-mentioned preferred embodiment is not construed as
Limitation of the invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (6)
1. a kind of antipruritic ointment containing wormwood extract, it is characterised in that the preparing raw material including following weight portion：Wormwood carries
Take 50 ~ 60 parts of thing, 20 ~ 25 parts of leaf of Moringa, 25 ~ 30 parts of Honeysuckle flower, 40 ~ 60 parts of glycerine, 130 ~ 140 parts of atoleine, hard
500 ~ 650 parts of 110 ~ 120 parts of resin acid, 8 ~ 10 parts of triethanolamine and water.
2. the antipruritic ointment containing wormwood extract as described in claim 1, it is characterised in that described to contain wormwood extract
Antipruritic ointment including following weight portion preparing raw material：It is 58 parts of wormwood extract, 22 parts of leaf of Moringa, 26 parts of Honeysuckle flower, sweet
586 parts of 50 parts of oil, 135 parts of atoleine, 114 parts of stearic acid, 9 parts of triethanolamine and water.
3. the antipruritic ointment containing wormwood extract as described in claim 1 or 2, it is characterised in that the wormwood extract
It is made up of wormwood volatile oil and wormwood alcohol extract；The preparation method of the wormwood volatile oil comprises the following steps：Fresh wormwood is taken,
Be placed in supercritical carbon dioxide extraction apparatus after rubbing, regulation and control carbon dioxide flow be 16 ~ 20L/h, extracting pressure be 15 ~
20MPa, extraction temperature is 30 ~ 35 DEG C, and extraction time is 1.5 ~ 2h, and decompression separation is obtained wormwood volatile oil, retains wormwood residual
Slag；The preparation method of the wormwood alcohol extract comprises the following steps：The wormwood residue is taken, the body of 4 ~ 6 times of residue weight is added
Fraction is 60 ~ 70% ethanol solution, is extracted at 60 ~ 70 DEG C 2 ~ 3 times, and 2 ~ 3h is extracted every time, and filtering merges extract solution,
It is 1.25 ~ 1.30 medicinal extract to be concentrated under reduced pressure into relative density at 60 DEG C, and wormwood alcohol extract is obtained.
4. the antipruritic ointment containing wormwood extract as described in claim 3, it is characterised in that the wormwood volatile oil and Chinese mugwort
The weight ratio of careless alcohol extract is（0.2~0.6）: 1.
5. a kind of method for preparing the antipruritic ointment containing wormwood extract as described in claim 1 or 2, it is characterised in that
Comprise the following steps：
S1, take fresh leaf of Moringa, rub, add the volume fraction of 6 ~ 8 times of its weight for 70 ~ 80% ethanol solution, microwave carries
Take 15 ~ 25min, microwave power is 600 ~ 800w, Extracting temperature is 45 ~ 55 DEG C, filtering, extract solution be concentrated under reduced pressure into 60 DEG C at phase
It is 1.25 ~ 1.30 medicinal extract to density, moringa oleifera leaf extractive is obtained；
S2, take fresh Honeysuckle flower, rub, add the volume fraction of 5 ~ 7 times of its weight for 60 ~ 70% ethanol solution, microwave carries
Take 15 ~ 25min, microwave power is 600 ~ 800w, Extracting temperature is 45 ~ 55 DEG C, filtering, extract solution be concentrated under reduced pressure into 60 DEG C at phase
It is 1.25 ~ 1.30 medicinal extract to density, Lonicera confusa extract is obtained；
S3, take glycerine, atoleine, stearic acid, triethanolamine and water and be placed in container, heating for dissolving simultaneously stirs, then
Natural condensation adds wormwood extract, moringa oleifera leaf extractive and Lonicera confusa extract to 40 ~ 45 DEG C, stirs, and obtains final product.
6. the antipruritic ointment containing wormwood extract is preparing treatment children's pruritus dermatopathy as described in claim 1 or 2
Medicine in purposes.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111956558A (en) * | 2020-09-17 | 2020-11-20 | 两面针（江苏）实业有限公司 | Artemisia argyi extract and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111956558A (en) * | 2020-09-17 | 2020-11-20 | 两面针（江苏）实业有限公司 | Artemisia argyi extract and preparation method and application thereof |
| CN111956558B (en) * | 2020-09-17 | 2022-09-09 | 两面针（江苏）实业有限公司 | Artemisia argyi extract and preparation method and application thereof |
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Application publication date: 20170531 |