CN109620881A - It is a kind of to have effects that the compound plant extract of antiphlogistic antibacterial and its application - Google Patents
It is a kind of to have effects that the compound plant extract of antiphlogistic antibacterial and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Has effects that the compound plant extract of antiphlogistic antibacterial the invention discloses a kind of, it is by shrubby sophora extract, common cnidium fruit P.E, coptis extract, phellodendron extract, pepper extract, Chinese sumac extract, borneol extract compounding, the effect of being each component collaboration, the effect of playing its bactericidal antiphlogistic, skin repair to greatest extent.Studies have shown that compound plant extract of the invention have effects that it is following: 1, anti-inflammation detumescence, desalinate skin eczema, infant eczema；2, Shu Min is antipruritic, desalinates pruitus and corticosteroid dermatitis；3, barrier reparation, scar repairing treat small pox etc., keep skin smooth fine and smooth；4, special effect is truly had to colpomycosis.Therefore, can be using it as active constituent, applied to scar agent of dispelling, acne print scavenger, renovation agent, fungicide, the preparation of feminine care agent can be used for preparing functional skin-protection product, such as essence, lotion, cream, facial mask.
Description
Technical field
The present invention relates to a kind of compound plant extracts with anti-inflammatory Shu Min, are mainly used for the system of function skin care item
It is standby, belong to Chinese medicine health-care and daily skin care field.
Background technique
Skin be safeguard human life and health important component, be the first barrier of body, directly with the external world
Contact, is highly prone to the influence of environmental factor and causes to damage.In recent years, since atmosphere pollution, all types of industries additive are abused
And the reasons such as variation of people's life habit, cause the crowd of the high sensitiveness of skin to increase year by year, occur easily it is red, swollen,
Heat pain, is itched, the skin allergy such as bits of peel, dermatitis and other facial skin problems, this has become influence people's appearance and health
A big factor.Therefore, the cleaning of skin and function nursing become increasingly important.
Summary of the invention
The object of the present invention is to provide a kind of compound plant extract composite plants with antiphlogistic antibacterial, main to use
In the preparation of function skin care item.
One, the ancestral grave of compound plant extract
Compound plant extract of the invention, be by shrubby sophora extract, common cnidium fruit P.E, coptis extract, phellodendron extract,
The collaboration of the effect of pepper extract, Chinese sumac extract, borneol extract compounding is each component, plays it to greatest extent and kills
The effect of bacterium anti-inflammatory, skin repair.
Kuh-seng, it is bitter, it trembles with fear.There are heat-clearing and damp-drying drug, desinsection, the function of diuresis.Studies have shown that kuh-seng contains matrine, oxymatrine
Oxygen has antiallergy, anti-inflammatory effect, beauty and skin care was just used for before the centuries.Frutus cnidii, warm-natured, acrid flavour, hardship.Have
Warm kidney, eliminating dampness, wind-dispelling, insecticidal action.Modern research shows that frutus cnidii mainly contains Osthole, there is anti-trichomonal effect, it is clinical
For treating trichomonas vaginitis.The present invention is monarch with kuh-seng, frutus cnidii, heat-clearing and damp-drying drug of advocating, and desinsection is antipruritic.
The coptis, cold in nature, bitter.Effect: heat-clearing and damp-drying drug, purging fire for removing toxin.Cortex Phellodendri, cold in nature, bitter.Effect and effect: heat-clearing
Eliminating dampness, purging intense heat, except steaming, detoxification sore treatment.Chinese prickly ash, Chinese prickly ash, acrid flavour, property heat have fragrant stomach invigorating, warming spleen and stomach for dispelling cold, damp dispelling and pain relieving, desinsection
The effect of removing toxic substances, antipruritic solution raw meat.The present invention further strengthens the efficiency of removing toxic substances eliminating dampness, together using the coptis, Cortex Phellodendri, Chinese prickly ash as ministerial drug
When promote skin and mucosa oedema absorb rapidly.
Chinese sumac is generally called Chinese gall tree, mainly contains gallic acid.Primary efficacy: 1, astriction: this product has the one of tannic acid
As pharmacological action, the tissue protein of the part such as skin, mucous membrane, ulcer can be made to solidify and play astriction, blood can be accelerated solidifying
Gu and having anastalsis；Alkaloid can be precipitated and have solution alkaloid intoxication；2, bacteriostasis: Chinese gall decoction is to golden yellow
Staphylococcus, bacterium flexneri, hog cholera bacillus and Escherichia coli have inhibiting effect.After proposing that it rubs acid with ether
Chinese gall liquid still has antibacterial action, and the ingredient of antibacterial action is primarily present in skin zone, and the boil liquid of center portion is then without antibacterial action；
3, anti-diarrhea effect: this product can penetrate intestinal tissue, and intestinal tube smooth muscle is inhibited to wriggle and have anti-diarrhea effect.The present invention is with Chinese sumac
Assistant, clearing heat and detoxicating, dissipating stasis and stanching bleeding.
Kapur has the effect of dredging the channel, nourishing qi and blood, at the same can make active constituent infiltrate into rapidly subcutaneously, from
And the effect of reaching Transdermal absorption；Kapur has very strong antibacterial, anti-inflammatory, antitoxin, analgesic activity；Extend thermostimulation and causes pain
Reaction time and pain reaction；It can inhibit influenza virus.Kapur can be obviously promoted wound healing, increase granulation tissue structure and table
Chrotoplast regeneration, repairs skin accessory organ and has stronger Wound Healing.Kapur has rush apoptosis to mutant
Effect, can induce cancer cell-apoptosis.The present invention is to make medicine with kapur, assists the monarch and his subjects' antibacterial, anti-inflammatory, antitoxic action.
The each component of compound plant extract is obtained by low temperature extraction technique.The technique is with moment high velocity stream
(maximum 300m/s) acts on material, realizes that material quickly and strong collision, causes plant cell moment to rupture, realize low temperature,
Quickly, constituents extraction entirely, so that heat-sensitive ingredients be effectively prevent to aoxidize and degradation.Therefore obtained extracting solution color, smell and taste and the original
Material is consistent, and effective component is consistent with plant material, ensure that the use of extracting solution and traditional plant clinical application are theoretical consistent.
In order to obtain preferable antibacterial and anti-inflammatory effects, each extract components are matched by following parts by weight: kuh-seng extracts
8 ~ 14 parts of object, 8 ~ 14 parts of common cnidium fruit P.E, 5 ~ 10 parts of coptis extract, 5 ~ 10 parts of phellodendron extract, pepper extract 4 ~ 7
Part, 3 ~ 5 parts of Chinese sumac extract, 1 ~ 3 part of borneol extract.
Optimum ratio: 9 ~ 12 parts of shrubby sophora extract, 9 ~ 12 parts of common cnidium fruit P.E, 7 ~ 8 parts of coptis extract, Cortex Phellodendri are extracted
7 ~ 8 parts of object, 4 ~ 5 parts of pepper extract, 3 ~ 4 parts of Chinese sumac extract, 2 ~ 3 parts of borneol extract.
Optimum proportioning: 10 parts of shrubby sophora extract, 10 parts of common cnidium fruit P.E, 8 parts of coptis extract, 8 parts of phellodendron extract,
6 parts of pepper extract, 4 parts of Chinese sumac extract, 2 parts of borneol extract.
Studies have shown that compound plant extract of the invention have effects that it is following: 1, anti-inflammation detumescence, desalinate skin eczema,
Infant eczema；2, Shu Min is antipruritic, desalinates pruitus and corticosteroid dermatitis；3, barrier reparation, scar repairing treat small pox
Deng keeping skin smooth fine and smooth；4, special effect is truly had to colpomycosis.It therefore, can be fiery active constituent with it, applied to scar of dispelling
Agent, acne print scavenger, renovation agent, fungicide, the preparation of feminine care agent can be used for preparing functional skin-protection product, such as
Essence, lotion, cream, facial mask etc..In order to reach good antimicrobial and anti-inflammation efficacy, compound plant extract adds in skin care item
Dosage is that mass fraction is calculated as 1.0-5.0wt.%.
Detailed description of the invention
Fig. 1 is the anti-inflammatory activity of composite plant anti-inflammatory Shu Min liquid of the present invention.
Fig. 2 is that composite plant anti-inflammatory Shu Min liquid of the present invention tests the inhibiting effect of inflammatory factor IL-1 and TNF-α.
Fig. 3 is to smear emulsifiable paste to have very strong inhibition to the expression of inflammatory factor IL-1 and TNF-α.
Specific embodiment
To the preparation of compound plant extract of the present invention and functional skin care item are being prepared below by specific embodiment
In concrete application be described further.
1, compound plant extract
Take 10 parts of shrubby sophora extract, 10 parts of common cnidium fruit P.E, 8 parts of coptis extract, 8 parts of phellodendron extract, pepper extract 6
Part, 4 parts of Chinese sumac extract, are mixed with suitable quantity of water/butanediol by 2 parts of borneol extract.The physical property of product is shown in Table 1:
2, compound plant extract active matter is tested
3, compound plant extract antibacterial activity is tested
Commission China, third party inspection mechanism survey detection the antibacterial activity of sample is tested, sample dilution 20 times after, according to
So there is very strong bactericidal activity, 5% composite plant antimicrobial fluid reaches 99% to the sterilizing rate of staphylococcus aureus, Candida albicans
The sterilizing rate of bacterium has reached 95%, and the sterilizing rate of escherichia coli has reached 63%, experiments have shown that the product has stronger sterilization
Activity, at the same it is green safe, it has no stimulation of the skin.
4, compound plant extract anti-inflammatory activity is tested
Eczema and steroid dependent dermatitis are that scytitis causes mostly, we use the anti-inflammatory cells of LPS inducing macrophage
Model tests the anti-inflammatory activity of composite plant anti-inflammatory Shu Min liquid.Fig. 1 is the anti-of composite plant anti-inflammatory Shu Min liquid of the present invention
Scorching activity.Fig. 1 is as the result is shown: prescription of the present invention has good antiphlogistic effects, and significant dose-effect relationship, anti-inflammatory activity is presented
Better than positive control drug aminoguanidine.
5, molecular pharmacology research
When eczema occurs, cell meeting great expression inflammatory factor inhibits the symptom of its horizontal eczema that can releive.Fig. 2 is this hair
Bright composite plant anti-inflammatory Shu Min liquid tests the inhibiting effect of inflammatory factor IL-1 and TNF-α.Molecular pharmacology researches show that:
Composite plant anti-inflammatory Shu Min liquid has very strong inhibiting effect to the expression of inflammatory factor IL-1 and TNF-α, and apparent amount is presented
Effect relationship.
6, animal pharmacological experiment
It is not less than 2 × 2 region cm2 shavings in back of mice with shaver, preserved skin uses 7% DNCB (dinitrofluorobenzene) one day after
Sensitization is carried out, the emulsifiable paste that composite plant anti-inflammatory Shu Min liquid is prepared is smeared, positive controls smear the Momestasone furoate cream of equivalent.
It is administered once a day later, until experiment terminates.Modeling mouse eczema is serious, and itch is hard to bear, is smearing composite plant anti-inflammatory Shu Min
After the ointment that liquid is prepared, itch disappears at once, and eczema is eliminated two days later, and new hair is grown after 1 week, and pharmacological effect is remote excellent
In positive control drug furfural Mometasone ointment.Fig. 3 is to smear emulsifiable paste to have very by force the expression of inflammatory factor IL-1 and TNF-α
Inhibition.
Claims (10)
- It 1. a kind of have effects that the compound plant extract of antiphlogistic antibacterial, is mentioned by shrubby sophora extract, common cnidium fruit P.E, the coptis Object, phellodendron extract, pepper extract, Chinese sumac extract are taken, borneol extract compounds.
- 2. a kind of as described in claim 1 have effects that the compound plant extract of antiphlogistic antibacterial, it is characterised in that: each plant Object extract is by following weight: 8 ~ 14 parts of shrubby sophora extract, 8 ~ 14 parts of common cnidium fruit P.E, coptis extract 5 ~ 10 Part, 5 ~ 10 parts of phellodendron extract, 4 ~ 7 parts of pepper extract, 3 ~ 5 parts of Chinese sumac extract, 1 ~ 3 part of borneol extract.
- 3. a kind of as described in claim 1 have effects that the compound plant extract of antiphlogistic antibacterial, it is characterised in that: each plant Object extract press following weight: 9 ~ 12 parts of shrubby sophora extract, 9 ~ 12 parts of common cnidium fruit P.E, 7 ~ 8 parts of coptis extract, 7 ~ 8 parts of phellodendron extract, 4 ~ 5 parts of pepper extract, 3 ~ 4 parts of Chinese sumac extract, 2 ~ 3 parts of borneol extract.
- 4. a kind of as described in claim 1 have effects that the compound plant extract of antiphlogistic antibacterial, it is characterised in that: each plant Object extract presses following weight: 10 parts of shrubby sophora extract, 10 parts of common cnidium fruit P.E, 8 parts of coptis extract, Cortex Phellodendri mention Take 8 parts of object, 6 parts of pepper extract, 4 parts of Chinese sumac extract, 2 parts of borneol extract.
- 5. having effects that the compound plant extract of antiphlogistic antibacterial is preparing the application in skin care item as described in claim 1.
- 6. have effects that the compound plant extract of antiphlogistic antibacterial is preparing the application in skin care item as claimed in claim 5, Be characterized in that: be using compound plant extract as active component, and using production skin care item customary adjuvant and technique be prepared into Mildy wash, smoothing toner, lotion, face cream, essence, facial mask.
- 7. have effects that the compound plant extract of oil control and acne removal is preparing the application in skin care item as claimed in claim 6, Be characterized in that: compound plant extract additive amount in skin care item is that mass fraction is calculated as 1.0 ~ 5.0wt.%.
- 8. having effects that application of the compound plant extract in preparation Feminine care solution of antiphlogistic antibacterial as described in claim 1.
- 9. have effects that application of the compound plant extract in preparation Feminine care solution of antiphlogistic antibacterial as claimed in claim 8, It is characterized by: be using compound plant extract as active component, and using production Feminine care solution customary adjuvant and technique It is prepared into.
- 10. having effects that compound plant extract the answering in preparation Feminine care solution of oil control and acne removal as claimed in claim 9 With, it is characterised in that: compound plant extract additive amount in Feminine care solution is that mass fraction is calculated as 1.0 ~ 5.0wt.%.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420266A (en) * | 2019-08-11 | 2019-11-08 | 广州川研化学科技有限公司 | A kind of three green pepper anti-acne anti-mite agent |
| CN110742837A (en) * | 2019-12-13 | 2020-02-04 | 汉源县昊业花椒产业研究院 | Anti-inflammatory mask and preparation method thereof |
| CN111228207A (en) * | 2020-03-11 | 2020-06-05 | 广州市逸轩精细化工有限公司 | Dampness-rash-eliminating hip-protecting cream and preparation method thereof |
| CN111388370A (en) * | 2020-04-02 | 2020-07-10 | 广州市逸轩精细化工有限公司 | Hair and bath two-in-one washing and protecting lotion for children and preparation method thereof |
| CN112006960A (en) * | 2020-09-15 | 2020-12-01 | 广州莱约生物科技有限公司 | Acne-removing and oil-controlling composition and preparation method and application thereof |
| US20210254845A1 (en) * | 2020-02-19 | 2021-08-19 | Microjet Technology Co., Ltd. | Miniature gas detection and purification device |
| CN113925907A (en) * | 2020-11-14 | 2022-01-14 | 四川省川科中医药产业发展有限公司 | Antibacterial anti-inflammatory and antiallergic composition as well as preparation method and application thereof |
| CN114404334A (en) * | 2022-01-28 | 2022-04-29 | 广州富煜陇生物科技有限公司 | Preparation and application of plant extract for anti-allergy itching-relieving repair |
| WO2024052756A1 (en) * | 2022-09-09 | 2024-03-14 | Crodarom | Use of an extract of sichuan pepper for a skin treatment and a composition suitable for this use. |
| FR3139466A1 (en) * | 2022-09-09 | 2024-03-15 | Crodarom | Use of a Sichuan pepper extract for skin treatment and a composition adapted to this use. |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110420266A (en) * | 2019-08-11 | 2019-11-08 | 广州川研化学科技有限公司 | A kind of three green pepper anti-acne anti-mite agent |
| CN110420266B (en) * | 2019-08-11 | 2021-07-16 | 广州川研化学科技有限公司 | Acne-removing and mite-removing agent with three kinds of pepper |
| CN110742837A (en) * | 2019-12-13 | 2020-02-04 | 汉源县昊业花椒产业研究院 | Anti-inflammatory mask and preparation method thereof |
| US20210254845A1 (en) * | 2020-02-19 | 2021-08-19 | Microjet Technology Co., Ltd. | Miniature gas detection and purification device |
| CN111228207A (en) * | 2020-03-11 | 2020-06-05 | 广州市逸轩精细化工有限公司 | Dampness-rash-eliminating hip-protecting cream and preparation method thereof |
| CN111228207B (en) * | 2020-03-11 | 2022-04-22 | 广州市逸轩精细化工有限公司 | Dampness-rash-eliminating hip-protecting cream and preparation method thereof |
| CN111388370A (en) * | 2020-04-02 | 2020-07-10 | 广州市逸轩精细化工有限公司 | Hair and bath two-in-one washing and protecting lotion for children and preparation method thereof |
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