CN104840505A - Application of aizoon stonecrop herb to preparation of composition for inhibiting itching caused by mosquito bite - Google Patents
Application of aizoon stonecrop herb to preparation of composition for inhibiting itching caused by mosquito bite Download PDFInfo
- Publication number
- CN104840505A CN104840505A CN201510313655.9A CN201510313655A CN104840505A CN 104840505 A CN104840505 A CN 104840505A CN 201510313655 A CN201510313655 A CN 201510313655A CN 104840505 A CN104840505 A CN 104840505A
- Authority
- CN
- China
- Prior art keywords
- herba sedi
- sedi aizoon
- preparation
- aizoon
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 33
- 206010003399 Arthropod bite Diseases 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 241000218093 Phedimus aizoon Species 0.000 title abstract description 7
- 230000007803 itching Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241001596270 Aizoon Species 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 12
- 239000006286 aqueous extract Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000002481 ethanol extraction Methods 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 239000002699 waste material Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 206010015150 Erythema Diseases 0.000 abstract description 3
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 208000002193 Pain Diseases 0.000 abstract description 3
- 230000008961 swelling Effects 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- 244000062730 Melissa officinalis Species 0.000 description 7
- 235000010654 Melissa officinalis Nutrition 0.000 description 7
- 230000001139 anti-pruritic effect Effects 0.000 description 7
- 239000000865 liniment Substances 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 6
- 239000003908 antipruritic agent Substances 0.000 description 5
- OLFGPECRQXQUAG-UHFFFAOYSA-N 1-[2-(2-hydroxy-2-phenylethyl)-1-methyl-3,6-dihydro-2h-pyridin-6-yl]propan-2-ol Chemical compound CN1C(CC(O)C)C=CCC1CC(O)C1=CC=CC=C1 OLFGPECRQXQUAG-UHFFFAOYSA-N 0.000 description 4
- 241000255925 Diptera Species 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 2
- 208000034507 Haematemesis Diseases 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- HSNZZMHEPUFJNZ-UHFFFAOYSA-N L-galacto-2-Heptulose Natural products OCC(O)C(O)C(O)C(O)C(=O)CO HSNZZMHEPUFJNZ-UHFFFAOYSA-N 0.000 description 2
- 206010027514 Metrorrhagia Diseases 0.000 description 2
- TYHJMEIBGDDCPA-UHFFFAOYSA-N N-Methylpelletierine Chemical compound CN1CCCCC1CC(C)=O TYHJMEIBGDDCPA-UHFFFAOYSA-N 0.000 description 2
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 2
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 229960000271 arbutin Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 229940100243 oleanolic acid Drugs 0.000 description 2
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 2
- 235000011837 pasties Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 2
- 238000006748 scratching Methods 0.000 description 2
- 230000002393 scratching effect Effects 0.000 description 2
- GOWRYACIDZSIHI-UHFFFAOYSA-N sedamine Natural products CN1CCCCC1CC(O)C1=CC=CC=C1 GOWRYACIDZSIHI-UHFFFAOYSA-N 0.000 description 2
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940096998 ursolic acid Drugs 0.000 description 2
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 2
- UPLPHRJJTCUQAY-WIRWPRASSA-N 2,3-thioepoxy madol Chemical compound C([C@@H]1CC2)[C@@H]3S[C@@H]3C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 UPLPHRJJTCUQAY-WIRWPRASSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000006479 Cyme Species 0.000 description 1
- HAIWUXASLYEWLM-UHFFFAOYSA-N D-manno-Heptulose Natural products OCC1OC(O)(CO)C(O)C(O)C1O HAIWUXASLYEWLM-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- HAIWUXASLYEWLM-AZEWMMITSA-N Sedoheptulose Natural products OC[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@](O)(CO)O1 HAIWUXASLYEWLM-AZEWMMITSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 240000000920 Typhonium flagelliforme Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 229940076810 beta sitosterol Drugs 0.000 description 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 208000024756 faint Diseases 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- HSNZZMHEPUFJNZ-SHUUEZRQSA-N sedoheptulose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO HSNZZMHEPUFJNZ-SHUUEZRQSA-N 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 229950005143 sitosterol Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an application of aizoon stonecrop herb to preparation of a composition for inhibiting itching caused by mosquito bite. Aizoon stonecrop herb refers to an aqueous extracting solution or ethanol extracting solution of aizoon stonecrop herb. Aizoon stonecrop herb can achieve the effect of effectively relieving pain or itching, skin red swelling and inflammations after mosquito bite, is safe and convenient to use and has an extensive application prospect.
Description
Technical field
The invention belongs to the applied technical field of a kind of Chinese medicinal ingredients in pharmaceutical composition, specifically relate to Herba Sedi Aizoon for the preparation of the application suppressed in pruritus due to mosquito bites compositions.
Background technology
Herba Sedi Aizoon has another name called Herba sedi kamtschatici (Herbal for Relief of Famines) Herba Senecionis Chrysanthemoidis (common name), the four seasons return to life from the nether world (Hubei), June drenches, receive Cortex Moutan, Shi Cailan, nine Flos Nelumbinis (Qinling Mountains flora), aizoon stonecrop herb (economic plants handbook), breast hair Herba Senecionis Chrysanthemoidis, Sedum aizoon L. var. floribundum Nakai, Radix Rhodiolae Yunnanensis, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), steamed buns stuffed with sweetened bean paste are returned to life from the nether world, Semen Sojae Preparatum is returned to life from the nether world, Typhonium flagelliforme (Lodd.) Blume, June return to life from the nether world, perennial meat draft, without hair, Gao Keda 80 centimetres.Root stock is slightly thick, nearly lignifying, and the aerial stem of plant is upright, not branch.Leaf alternate, or be close to life; Extensively avette to falling lanceolar, long 5 ~ 8 centimetres, the blunt or slightly point of tip, edge tool serration, or nearly full edge, base portion is gradually narrow, smooth or slightly mamillary is coarse.Corymbiform cyme top is raw; Stockless or intimate stockless; Sepal 5, different in size, be about 1/2 into petal, linear to lanceolar, tip is blunt; Petal 5, yellow, oval shape lanceolar, the short point of tip tool; Stamen 10, short compared with petal; Carpel, slightly carries out, and base portion is connected slightly.Follicle radish fruit 5 pieces becomes the arrangement of asterism shape.Seed is level and smooth, and the narrow wing of edge tool, top is wider.6 ~ August of florescence, fruit phase 8 ~ JIUYUE.
As a kind of Chinese medicinal ingredients, Herba Sedi Aizoon has medical value widely, can be used for dissipating blood stasis; Hemostasis; Mind tranquilizing and the heart calming; Removing toxic substances.Main haematemesis; Epistaxis; Have blood in stool; Hematuria; Metrorrhagia; Purpura; Traumatic hemorrhage; Traumatic injury; Cardiopalmus; Insomnia; Furuncle carbuncle; Burn and scald; Insect bite.In the market mainly as a kind of Herba Sedi Aizoon edible or as the health promoting beverage of three-hypers crowd, its chemical analysis is mainly: sedoheptose (sedoheptulose), sucrose, fructose, oleanolic acid (oleanolic acid), cupreol (β-sitosterol), ursolic acid (ursolicacid), arbutin (arbutin), ammonia quinone (hydro-quinone), racemization-methylisopelletierine (methylisop elletierine), left-handed sedinine (sedinine), racemization sedamine (sedamine) paddy mykol, the ingredient such as flavone and vitamin E.
In summer, mosquito wreaks havoc, and human body is easy to by mosquito bite, and skin is bitten often be there will be pruritus and presents red and swollen state afterwards, affects routine work and rest, the place of biting is scratched causes dermatitis then, leave scar or occur anaphylactic reaction.Solve the emphasis of the various skin pruritus after mosquito bite, red and swollen diseases prevention and treatment in summer always.For treatment mosquito control is to the symptom of human body, usually adopt XILEI SAN or anti-inflammation analgesic, but this kind of medicine major part is the synthetic of chemical classes composition, uses inconvenience and life-time service can cause damage to skin.In Chinese medicine, find suitable plant variety, the product research launching associated treatment mosquito bite symptom is a direction of alleviating and alleviating disease in summer.
Summary of the invention
The object of the invention is in order to for summer human body by the symptom after mosquito bite, propose a kind ofly to utilize Herba Sedi Aizoon to suppress the application in pruritus due to mosquito bites compositions in preparation.
Realizing above-mentioned purpose technical scheme of the present invention is, by Herba Sedi Aizoon for the preparation of the purposes suppressing pruritus due to mosquito bites compositions.Herba Sedi Aizoon is mainly used in hemostasis at existing field of medicaments, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain; And the application studies discovery for symptoms such as the pruritus after mosquito bite, swelling, utilize Herba Sedi Aizoon or its extracting solution can play effective improvement, alleviate and itch the senses of discomfort such as pain and eliminate redness, this purposes is a kind of new Therapeutic Method.
Above-mentioned Herba Sedi Aizoon for the preparation of in the application suppressed in pruritus due to mosquito bites compositions, the Herba Sedi Aizoon in compositions is Herba Sedi Aizoon alcohol extract or aqueous extract.The effect utilizing the extracting solution of Herba Sedi Aizoon can make it in treatment mosquito bite symptom is more obvious; And extracting solution also easier and other materials mixes, the various multi-form treatment product of more convenient preparation.
Wherein, aqueous extract is obtained by following method: smash Herba Sedi Aizoon to pieces rear adding distil water, be heated to boil, use 20-30min at a simmer again, gauze coarse filtration, stay its filtrate, medicinal residues are added water again, 20-30min at a simmer, filters waste, merges twice filtrate, heating is concentrated, adjust pH to 6.5-7.5, after centrifugal, get supernatant for subsequent use.
Alcohol extract is obtained by following method: Herba Sedi Aizoon adds the ethanol extraction 45-60min of 80-85% after smashing to pieces, and the filtering residue after filtration adds the ethanol extraction 20-30min of 70-75% again, merges twice alcohol extract.
The alcohol extract of Herba Sedi Aizoon or aqueous extract effectively can alleviate sufferings, red swelling of the skin and inflammation after mosquito bite, and use safety, convenience, its application direction has bright prospects.
In a word, the technical scheme of the present patent application, Herba Sedi Aizoon is the application direction of the novelty of Herba Sedi Aizoon for the preparation of suppressing the purposes of pruritus due to mosquito bites compositions, particularly proposes a new research topic to the treatment of mosquito bite symptom.
Detailed description of the invention
Below technical scheme of the present invention is specifically described.
Embodiment 1
Preparation is containing the aqueous extract of Herba Sedi Aizoon: Herba Sedi Aizoon 100g cleans, and smashs into pasty state to pieces, adding distil water 1000ml, be heated to boil, then use 30min at a simmer, gauze coarse filtration, stay its filtrate, medicinal residues are added water again, 30min at a simmer, filter waste, merge twice filtrate, heating is concentrated into 100ml, adjusts pH to 7, again with the centrifugal 15min of 1600r/min, get supernatant for subsequent use.
Choosing 80 examples is bitten in patient, male 44 example, women 36 example, the age 20-50 year between.By mosquito bite pruritus position all more than two places.Bitten and treatment time all between in June, 2014-August.Pruritus person chooses pruritus position voluntarily, and the aqueous extract 3ml getting Herba Sedi Aizoon is applied in a pruritus position, place, and another place's pruritus position hands scratching is antipruritic.
Antipruritic effect criterion: two kinds of method any one methods use and pruritus position can be made for twice antipruritic, and do not cause skin ulceration person for excellent, use five energy antipruritic, and do not cause skin ulceration person for good.As long as cause skin ulceration to be infection.In two days, two kinds of method any one methods use and are inefficacy more than five times.The therapeutic effect of two kinds of methods is in table 1.
Table 1 is by the contrast of the person of biting self two kinds of antipruritic methods of difference
As shown in Table 1, the acceptance rate that Herba Sedi Aizoon extracting solution of the present invention is applied at pruritus position in side reaches 96.25%.And self-controlled group only has 23 people to adopt the method for scratching to make the redness the being snapped position pruritus that disappears stop in 5 times, its acceptance rate only has 37.5%.Application Herba Sedi Aizoon extracting solution only has a few peoples to cause infection.
Embodiment 2
Preparation is containing the aqueous extract of Herba Sedi Aizoon: dry Herba Sedi Aizoon 150g, smashs rear adding distil water 1000ml to pieces, is heated to boil, use 20min at a simmer again, gauze coarse filtration, stay its filtrate, medicinal residues are added water again, 30min at a simmer, filters waste, merges twice filtrate, heating is concentrated into 80ml, adjust pH to 7.2, then with the centrifugal 15min of 1600r/min, get supernatant for subsequent use.
Choose 120 examples by mosquito bite pruritus patient, male 48 example, women 52 example, the age 20-40 year between.Patient is divided into two groups at random, and one group is of the present invention group, and the aqueous extract 2ml getting Herba Sedi Aizoon smears pruritus position; Another group is essential balm group, smears essential balm 2ml in pruritus position.
Two kinds of method any one methods use and scratchiness person of completely not disappearing can be made for twice to be effective, and scratchiness alleviator is effective, treat scratchiness after 2 days have no be improved as invalid.The therapeutic effect of two kinds of methods is in table 2.
The contrast of extracting solution of the present invention and the difference antipruritic method of essential balm two kinds applied by table 2
As shown in Table 2, have the aqueous extract of 64 individual application Herba Sedi Aizoons to reach good effect in of the present invention group, the effective percentage of of the present invention group reaches 53.3%; Only have 38 people to apply essential balm in essential balm group and reach good effect, effective percentage is 31.7%.The antipruritic effect of the extracting solution of application Herba Sedi Aizoon of the present invention is better than application essential balm, can substitute essential balm for suppressing the pruritus caused by mosquito.
Embodiment 3
Preparation is containing the alcohol extract of Herba Sedi Aizoon: Herba Sedi Aizoon 200g cleans, and smash into pasty state to pieces, the ethanol 1000ml adding mass fraction 80% extracts 1 hour, and the filtering residue after filtration adds mass fraction 75% ethanol 600ml and extracts 30min, merges twice alcohol extract for subsequent use.
Clinical practice
1, case summer because of moist mosquito more, apply treatment mosquito bite 230 of the present invention example, male 122 example, women 108 example, age 18-35 year, wherein with secondary infection 28 example, be applied in the pruritus place of skin with the alcohol extract 2ml that cotton swab dips Herba Sedi Aizoon, smeared once every 1 hour, smear 3 times altogether.
2, criterion of therapeutical effect is cured: scratchiness does not disappear person completely; Effective: pruritus alleviator; Invalid: after smearing 3 times, scratchiness has no improvement.
3, result cures 180 examples (78.26%), effective 47 examples (20.43%), and invalid 3 examples (1.31), total effective rate is 98.69%.
Therefore, above-mentioned use demonstrates Herba Sedi Aizoon for the preparation of the purposes suppressing pruritus due to mosquito bites compositions, and this application is a kind of new application direction.
Technique scheme only embodies the optimal technical scheme of technical solution of the present invention, and those skilled in the art all embody principle of the present invention to some variations that wherein some part may be made, and belong within protection scope of the present invention.
Claims (4)
1. Herba Sedi Aizoon is for the preparation of the application suppressed in pruritus due to mosquito bites compositions, it is characterized in that, Herba Sedi Aizoon is for the preparation of the purposes suppressing pruritus due to mosquito bites compositions.
2. Herba Sedi Aizoon according to claim 1 is for the preparation of the application suppressed in pruritus due to mosquito bites compositions, and it is characterized in that, described Herba Sedi Aizoon is the aqueous extract of Herba Sedi Aizoon or the alcohol extract of Herba Sedi Aizoon.
3. Herba Sedi Aizoon according to claim 2 is for the preparation of the application suppressed in pruritus due to mosquito bites compositions, it is characterized in that, the aqueous extract of Herba Sedi Aizoon is obtained by following method: smash Herba Sedi Aizoon to pieces rear adding distil water, be heated to boil, use 20-30min at a simmer again, gauze coarse filtration, stays its filtrate; Added water by medicinal residues, 20-30min at a simmer, filters waste, merges twice filtrate, and heating is concentrated, adjusts pH to 6.5-7.5, after centrifugal, gets supernatant for subsequent use again.
4. Herba Sedi Aizoon according to claim 2 is for the preparation of the application suppressed in pruritus due to mosquito bites compositions, it is characterized in that, the alcohol extract of Herba Sedi Aizoon is obtained by following method: Herba Sedi Aizoon adds the ethanol extraction 45-60min of 80-85% after smashing to pieces, filtering residue after filtration adds the ethanol extraction 20-30min of 70-75% again, merges twice alcohol extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510313655.9A CN104840505A (en) | 2014-06-16 | 2015-06-09 | Application of aizoon stonecrop herb to preparation of composition for inhibiting itching caused by mosquito bite |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410264987 | 2014-06-16 | ||
| CN2014102649878 | 2014-06-16 | ||
| CN201510313655.9A CN104840505A (en) | 2014-06-16 | 2015-06-09 | Application of aizoon stonecrop herb to preparation of composition for inhibiting itching caused by mosquito bite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104840505A true CN104840505A (en) | 2015-08-19 |
Family
ID=53840753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510313655.9A Pending CN104840505A (en) | 2014-06-16 | 2015-06-09 | Application of aizoon stonecrop herb to preparation of composition for inhibiting itching caused by mosquito bite |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104840505A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924326A (en) * | 2017-04-17 | 2017-07-07 | 西安培华学院 | A kind of horizontal root takes dish extract and its production and use |
| CN114224931A (en) * | 2021-12-31 | 2022-03-25 | 南京豆葵生物有限公司 | Preparation method of aizoon stonecrop herb extract |
-
2015
- 2015-06-09 CN CN201510313655.9A patent/CN104840505A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 刘学杰等: "景天三七的现代研究进展 ", 《齐鲁药事》 * |
| 王硕等: "《中医养生有良方》", 31 October 2011, 中国中医药出版社 * |
| 谭苹等: "40种秦岭"七药"最低抑菌浓度的测试", 《时珍国医国药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924326A (en) * | 2017-04-17 | 2017-07-07 | 西安培华学院 | A kind of horizontal root takes dish extract and its production and use |
| CN114224931A (en) * | 2021-12-31 | 2022-03-25 | 南京豆葵生物有限公司 | Preparation method of aizoon stonecrop herb extract |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Khare | Indian herbal remedies: rational Western therapy, ayurvedic, and other traditional usage, Botany | |
| CN101401860A (en) | Externally-applied medicament composition for treating dermatosis | |
| CN104147533A (en) | Blood-activating, stasis-resolving and pain-relieving cream and preparation method thereof | |
| CN103041042B (en) | Tibetan medicine composition and application of composition in anti-off hair products | |
| CN108498390B (en) | Tibetan herbal extract for treating acne and preparation method and application thereof | |
| CN104173517B (en) | The Chinese medicine preparation for the treatment of primary trigeminal neuralgia and preparation method | |
| CN103239662A (en) | Parasite expelling Chinese herbal preparation for animals | |
| CN105125467A (en) | Emulsion removing red blood and preparing method of emulsion | |
| CN105213256A (en) | A kind of Shu Min dispels red toner/smoothing toner and preparation method thereof | |
| CN104840505A (en) | Application of aizoon stonecrop herb to preparation of composition for inhibiting itching caused by mosquito bite | |
| CN101507743A (en) | Biennial wormwood extract and preparation method thereof | |
| CN104587101A (en) | Traditional Chinese medicine spray for promoting healing of postoperative incision and preparation method | |
| CN103845616A (en) | Pharmaceutical composition for eliminating inflammation and disinfecting | |
| CN103417781A (en) | Traditional Chinese medicine for treating surgical wounds | |
| CN102764345A (en) | Basil-bluegum ointment for curing burns and preparation method thereof | |
| CN106177060A (en) | A kind of U.S. rattan fruit wound oil | |
| CN105168091A (en) | Telangiectasis removing mask powder and preparation method thereof | |
| CN106728069B (en) | Slough-removing and tissue regeneration-promoting paste for treating scalds and burns | |
| CN104971286A (en) | Traditional Chinese medicine composition for treating shoulder, waist and leg discomfort | |
| CN103893554A (en) | Tea oil medicinal preparation for treating skin burns and preparation method of preparation | |
| CN103919888A (en) | Composite hair tonic and preparation method thereof | |
| CN104873723B (en) | A kind of burn-scald medicine containing cinnamon oil | |
| CN108714167B (en) | A Chinese medicinal preparation for external use for treating vitiligo, and its preparation method | |
| CN105125801B (en) | Spray for relieving itching of puerpera incision and preparation method | |
| CN105012503A (en) | Ointment for treating scalding and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170421 Address after: 452392 Xinmi City, Zhengzhou Province, Niu Zhen Village platform North West Group Applicant after: Chen Xiaofeng Address before: No. 6 silver Kunming Science and Technology Park 471000 Henan province Luoyang Fenghua high tech Development Zone, Road No. 5 building 307 Applicant before: Luoyang Gu Cheng Bioisystech Co., Ltd |
|
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150819 |