CN104147533A - Blood-activating, stasis-resolving and pain-relieving cream and preparation method thereof - Google Patents
Blood-activating, stasis-resolving and pain-relieving cream and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a blood-activating, stasis-resolving g and pain-relieving cream and a preparation method thereof. The cream includes following substances: safflower seed oil, evening primrose oil, horse oil, hippophae fruit oil, curcuma zedoary oil, mint oil, borneol, menthol, azone, ethanol, a multifunctional emulsifying agent G57, a universal self-emulsifying composite-type emulsifying agent AC-402, a panax notoginseng extract, a safflower extraxt, a radix fici hirtae extract, a cibotium barometz extract, an alangium chinense extract, a zanthoxylum nitidum extraction, 5% sodium carboxymethylcellulose, ethylparaben, 1,2-propanediol, water and essences. Compared with a cream in the prior art, the blood-activating, stasis-dispelling and pain-relieving cream has a cream substrate which contains six traditional Chinese medicine extracts including extracts of panax notoginseng, safflower, radix fici hirtae, cibotium barometz, alangium chinense and zanthoxylum nitidum. The cream has effects of activating blood, resolving stasis, dispersing swelling, relieving pain, clearing heat, cooling blood and promoting tissue regeneration. The cream can enable rheumatism bone pain, bruise, swellings, slight scald, chilblain and the like to be healed early and meanwhile has a basically nourishing function.
Description
Technical field
The present invention relates to a kind of emulsifiable paste, particularly a kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste and preparation method thereof.
Background technology
Rheumatic ostalgia disease is the commonly encountered diseases that a kind of sickness rate is very high, generally adopts two kinds of methods of the traditional Chinese medical science and doctor trained in Western medicine to treat.More effective for the Itai-itai diseases western medical treatment causing because of inflammation, but for the rheumatic ostalgia disease of bringing out because of factors such as wound, strain, colds, the general effect of western medical treatment is poor, even there is no effect, also easily recurrence, and Western medicine usually has very large side effect.
The applicating history of promoting blood circulation, removing blood stasis and relieving pain Chinese medicine is long, and clinical practice is very extensive.It can not only alleviate and eliminate the painful of patient and eliminate pain disease to a certain extent, because treating both the principal and secondary aspects of a disease improves the rate of recovering, evident in efficacy to some severe intractable pain especially.With the object that medicine for external use reaches analgesia detumescence, blood circulation promoting and blood stasis dispelling, dredging collateral eliminating impediment be China's traditional Chinese traditional treatment method since ancient times, it can Zhi Genzhiben, thoroughly eradicate osteodynia disease.
Conventional ointment has rheumatism plaster, SHANGSHI ZHITONG GAO etc., but these plaster have reasonable effect for different cases, but it has the shortcoming of the function singleness of curing mainly, especially for the not good curative effect of lumbago and skelalgia due to treatment rheumatic hypertrophy.
Summary of the invention
There is natural component extract, there is Eradicates wind prevailing over dampness, invigorating blood circulation to turn to solves the problems of the technologies described above, and the invention provides a kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste, containing the effect of the stasis of blood, removing obstruction in the collateral to relieve pain.
The present invention also provides a kind of preparation method of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
A kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, 60g promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste contains following material:
Described Radix Notoginseng extracting solution is prepared by the following method:
Take Radix Notoginseng appropriate, be ground into coarse powder, use 50%-90% alcohol reflux three times, doubly measure solvent extraction 0.5-2h with 6-18 for the first time, filter, doubly measure solvent extraction 0.5-2h with 6-12 for the second time, filter, doubly measure solvent extraction 0.5-2h with 6-12 for the third time, filter, three times filtrate merges, and 6-15 times of g/ml of volume simmer down to three seven weight of filtrate, obtains Radix Notoginseng extracting solution.
Described Flos Carthami extract is prepared by the following method:
Take Flos Carthami appropriate, reflux, extract, twice, adds 6-15 times of water gaging for the first time, soaks ultrasonic 0.5-1h, extract 0.5-2h, filter, add for the second time 6-15 times of water gaging, extract 0.5-2h, filter, twice filtrate merges, and 5-15 times of g/ml of the volume simmer down to Flos Carthami weight of filtrate, obtains Flos Carthami extract.
Described Herba Fici Simplicissimae extracting solution is prepared by the following method:
Take Herba Fici Simplicissimae appropriate, be crushed to coarse powder, reflux, extract, three times, add for the first time 5-15 times of water gaging, soak ultrasonic 0.5-1h, extract 0.5-2h, filter, add for the second time 5-15 times of water gaging, extract 0.5-2h, filter, add for the third time 6-12 times of water gaging, extract 0.5-2h, filter, three times filtrate merges, and 5-15 times of g/ml of the volume simmer down to Herba Fici Simplicissimae weight of filtrate, obtains Herba Fici Simplicissimae extracting solution.
Described Rhizoma Cibotii extracting solution is prepared by the following method:
Take Rhizoma Cibotii appropriate, with 40%-80% alcohol reflux three times, doubly measure solvent extraction 0.5-2h with 8-24 for the first time, filter, doubly measure solvent extraction 0.5-2h with 8-24 for the second time, filter, doubly measure solvent extraction 0.5-2h with 6-15 for the third time, filter, three times filtrate merges, 5-15 times of g/ml of volume simmer down to Rhizoma Cibotii weight of filtrate, obtains Rhizoma Cibotii extracting solution.
Described Radix Alangii extracting solution is prepared by the following method:
Take Radix Alangii appropriate, with containing the tartaric 40%-95% alcohol reflux of 0.5%-5% three times, doubly measure and extract 0.5-2h with 6-18 for the first time, filter, doubly measure and extract 0.5-2h with 6-12 for the second time, filter, doubly measure and extract 0.5-2h with 6-12 for the third time, filter, three times filtrate merges, 5-15 times of g/ml of volume simmer down to Radix Alangii weight of filtrate, obtains Radix Alangii extracting solution.
Described Radix Zanthoxyli extracting solution is prepared by the following method:
Take Radix Zanthoxyli appropriate, with containing 40%-95% alcohol reflux three times, doubly measure reflux, extract, 0.5-2h with 6-18 for the first time, filter, doubly measure and extract 0.5-2h with 6-18 for the second time, filter, doubly measure and extract 0.5-2h with 6-18 for the third time, filter, three times filtrate merges, 5-15 times of g/ml of volume simmer down to Radix Zanthoxyli weight of filtrate, obtains Radix Zanthoxyli extracting solution.
The preparation method of a kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, comprises the following steps:
A) respectively by safflower oil 0.2-4g, Radix Oenotherae erythrosepalae oil 0.2-3g, house oil 0.2-2.5g, Oleum Hippophae 0.1-1.2g, azone 0.1-1.2g, multi-functional emulsifier G570.2-2g, general-purpose self emulsifying mixed emulsifier AC-4020.2-2g weighs up, and is placed in beaker, and beaker is put in 60 DEG C of-90 DEG C of water-baths and is heated, treat to melt completely, mix homogeneously is oil solution A.
B) by Borneolum Syntheticum 0.1-1g, Mentholum 0.1-1g weighs up, and dissolves and is placed in the interior alcoholic solution B of being of beaker with 75% ethanol 1-5ml.
C) by Radix Notoginseng extracting solution 0.5-2ml, Flos Carthami extract 0.5-2ml, Herba Fici Simplicissimae extracting solution 0.5-2ml, Rhizoma Cibotii extracting solution 1-3ml, Radix Alangii extracting solution 1-3ml, Radix Zanthoxyli extract 1-3ml measures, be placed in beaker, beaker is put in 60 DEG C of-90 DEG C of water-baths and is heated, and mix homogeneously, is solution of additive C.
D) water 25-60ml being measured and is placed in beaker, beaker is put in 60 DEG C of-90 DEG C of water-baths and is heated, is aqueous solution D.
E) dissolving ethyl hydroxybenzoate 0.01-1g with 1,2-PD 1-5ml, be placed in beaker, is antiseptic solution E.
F) after oil phase A dissolves completely, add Oleum Curcumae 0.2-1.2g, Oleum menthae 0.1-0.8g is total to after hot 20-30s, add aqueous solution D stirring and evenly mixing, after 1-2min, add again alcoholic solution B and solution of additive C to continue stirring and evenly mixing, then add 5% sodium carboxymethyl cellulose 2-10g to stir, finally add antiseptic solution E and essence 0.1-0.5g, stirring and evenly mixing, obtains promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
Various compositions in the present invention are as follows:
Safflower oil claims again safflower oil, it is containing nutritional labelings such as Palmic acid, stearic acid, oleic acid, linoleic acid, vitamin E, oryzanol, sterols, prevent and treat arteriosclerosis and reduce blood cholesterol levels, blood circulation promoting, detumescence, dredging the meridian, the effect of blood circulation promoting and blood stasis dispelling.Wherein be rich in natural Vitamin E, its extremely strong permeability also makes the vitamin E in safflower oil very easily be absorbed by the body.
Radix Oenotherae erythrosepalae oil is mainly from evening primrose seed.Radix Oenotherae erythrosepalae oil, to improve skin quality, defying age, promotion hair glossy, regulates blood pressure, improves blood circulation, promoting blood circulation to remove obstruction in the collateral, and there is medical, medical value widely the aspects such as detumescence, sore, antiinflammatory.It can help wound healing, contribute to the joint of maintaining healthy and the inflammation symptom of other tissue of prevention, contribute to treat eczema, dermatitis, this class dermatosis of wind dampness rheumatic anesthesia pain, eliminate the inflammation such as rheumatic arthritis, ulcer joint enteritis, gastritis, improve multiple spondylitis, the inflammation symptom that lupus erythematosus etc. cause.
House oil contains abundant natural nutrient, highly unsaturated fatty acid and vitamin e, and permeability is strong, can promote human body vis medicatrix naturae and metabolism.Affinity, the stretchability of house oil to skin is good, especially contributes to eczema, scald, the recovery of disgrace skin ulcer.
In Oleum Hippophae, total flavones can increase Nutritional myocardium blood flow amount, improves Myocardial Microcirculation, improves preferably blood supply of cardiac muscle state, suppresses thrombosis, has the effect of promoting blood circulation to remove blood stasis, contributes to the recovery of traumatic injury.
Oleum menthae contains abundant menthol, has the effect of antiinflammatory, analgesia, cooling skin, the sensation that it is refrigerant, can shrink blood capillary, releive itch, inflammation and the skin of burning.Can adopt Oleum menthae to treat slight skin pruritus, the inflammation of releiving, red and swollen skin, pain relieving.
Mentholum has the special aroma of Herba Menthae, and taste is just scorching hot rear refrigerant, can optionally stimulate the Cold receptor of human body skin or mucosa, produces sense of cold reflection and creeping chill.External can antiinflammatory, pain relieving, and antipruritic, blood circulation promoting, alleviates edema etc.; For oral administration can alleviate local inflammation (pharyngolaryngitis) in compound preparation.
Radix Notoginseng has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Because Radix Notoginseng is all panax species, and its effective active matter higher than with more than Radix Ginseng, be therefore called " king in ginseng " by modern Chinese medicine medicine scholar again.Function cures mainly hemostasis dissipating blood stasis, and subduing swelling and relieving pain is flutterred blood stasis for falling, traumatic hemorrhage, carbuncle pain.
Oleum Curcumae is for back extremity pain, innominate toxic swelling, traumatic injury, scalds and burns, snakeworm scorpion Canis familiaris L. Scolopendra wound, traumatic hemorrhage etc.The circulation of qi promoting of this product removing blood stasis, removing food stagnancy pain relieving, blood stasis dispelling.
The similar Camphora of Borneolum Syntheticum reducing swelling and alleviating pain effect, has heat clearing away, antipruritic, pain relieving, antisepsis, can be used for neuralgia and antiinflammatory.
Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, be applicable to that blood stasis is had a pain, carbuncle, traumatic injury, various varicosis, peripheral neuritis, lower limb numbness or the blood stasis disease such as livid purple.
Herba Fici Simplicissimae has the merit of dampness removing relaxing muscles and tendons, and psoralen is its main active, for diseases such as rheumatic arthralgia.
Rhizoma Cibotii belongs to strong muscles and bones medicine, and the disease that muscles and bones is not good for has the dual function for the treatment of and health care.Cure mainly stiffness along the spinal column pain, can not pitching, the diseases such as sufficient knee joint weakness and lumbago due to pathogenic wind-dampness.
Radix Alangii promoting blood circulation to remove blood stasis, energy expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, eliminating stasis to stop pain, for rheumatic arthralgia, numb limbs and tense tendons, traumatic injury; Leaf is hemorrhage for injury and bone fracture, knife injury.
Radix Zanthoxyli energy dissipating blood stasis is active, the removing toxic substances of dispeling the wind.Function cures mainly: promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral.The traumatic injury, rheumatic arthralgia, stomachache, the toothache that cause for qi depression to blood stasis, venom, external treatment is scalded.
In this promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste prescription, add a large amount of rare Chinese medicines and extracted composition.All medicines share, and jointly play effect of promoting blood circulation and stopping pain, channels sootheing and network vessel quickening.
Compare with prior art, promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, in mastic substrate, contain the extract of Radix Notoginseng, Flos Carthami, Herba Fici Simplicissimae, Rhizoma Cibotii, Radix Alangii, Radix Zanthoxyli Six-element Chinese medicine, invigorate blood circulation, blood stasis dispelling, reducing swelling and alleviating pain, clearing away heat and cooling blood granulation promoting, can make the healings early such as rheumatic ostalgia, stasis of blood green grass or young crops, lump or slight scald, chilblain, there is basic maintenance function simultaneously.Ointment made by medicine by the present invention, easy to use and carry; It is faint yellow that emulsifiable paste is, suitable viscosity, and hardness is suitable, and mastic is evenly fine and smooth, and stretchability is good, uses rear cool and comfortable, good stability, abnormal smells from the patient is pure and fresh simple and elegant.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
The preparation of 1.1 Radix Notoginseng extracting solution:
Take Radix Notoginseng 200g, with 75% alcohol reflux three times, with 10 times of amount 75% ethanol extraction 1.5h, filter for the first time, for the second time with 8 times of amount 75% ethanol extraction 1h, filter, with 8 times of amount 75% ethanol extraction 1h, filter for the third time, three times filtrate merges, 10 times of g/ml of simmer down to medical material amount, obtain Radix Notoginseng extracting solution.
The preparation of 1.2 Flos Carthami extracts:
Take Flos Carthami 50g, reflux, extract, twice, adds 10 times of water gagings for the first time, soaks ultrasonic 0.5h, extracts 1.5h, filters, and adds for the second time 8 times of water gagings, extracts 1h, filters, and twice filtrate merges, and 10 times of g/ml of simmer down to medical material amount, obtain Flos Carthami extract.
The preparation of 1.3 Herba Fici Simplicissimae extracting solution:
Take Herba Fici Simplicissimae 100g, be crushed to coarse powder, reflux, extract, three times, add for the first time 10 times of water gagings, soak ultrasonic 0.5h, extract 1.5h, filter, add for the second time 8 times of water gagings, extract 1h, filter, add for the third time 8 times of water gagings, extract 1h, filter, three times filtrate merges, and 10 times of g/ml of simmer down to medical material amount, obtain Herba Fici Simplicissimae extracting solution.
The preparation of 1.4 Rhizoma Cibotii extracting solution:
Take Rhizoma Cibotii appropriate, with 60% alcohol reflux three times, with 20 times of amount 60% alcohol reflux 1.5h, filter for the first time, for the second time with 15 times of amount 60% alcohol reflux 1h, filter, with 10 times of amount 60% alcohol reflux 1h, filter for the third time, three times filtrate merges, concentrating under reduced pressure is 10 times of g/ml of medical material amount, obtains Rhizoma Cibotii extracting solution.
The preparation of 1.5 Radix Alangii extracting solution:
Take Radix Alangii 200g, with containing 1% tartaric 80% alcohol reflux three times, extract 1.5h with 10 times of amount solvent refluxings for the first time, filter, extract 1h with 8 times of amount solvent refluxings for the second time, filter, extract 1h with 8 times of amount solvent refluxings for the third time, filter, three times filtrate merges, 10 times of g/ml of simmer down to medical material amount, obtain Radix Alangii extracting solution.
The preparation of 1.6 Radix Zanthoxyli extracting solution:
Take Radix Zanthoxyli 300g, with containing 80% alcohol reflux three times, extract 1.5h with 10 times of amount solvent refluxings for the first time, filter, extract 1h with 8 times of amount solvent refluxings for the second time, filter, extract 1h with 8 times of amount solvent refluxings for the third time, filter, three times filtrate merges, 10 times of g/ml of simmer down to medical material amount, obtain Radix Zanthoxyli extracting solution.
The preparation of 1.7 promoting blood circulation, removing blood stasis and relieving pain emulsifiable pastes
A) divide safflower oil 3g, Radix Oenotherae erythrosepalae oil 3g, house oil 2g, Oleum Hippophae 0.2g, azone 0.2g, multi-functional emulsifier G570.3g, general-purpose self emulsifying mixed emulsifier AC-4020.3g weighs up, and is placed in beaker, and beaker is put in 70 DEG C of water-baths and is heated, treat to melt completely, mix homogeneously is oil solution A.
B) by Borneolum Syntheticum 0.2g, Mentholum 0.2g weighs up, and dissolves and is placed in the interior alcoholic solution B of being of beaker with 75% ethanol 2ml.
C) by Radix Notoginseng extracting solution 2ml, Flos Carthami extract 2ml, Herba Fici Simplicissimae extracting solution 2ml, Rhizoma Cibotii extracting solution 2ml, Radix Alangii extracting solution 2ml, Radix Zanthoxyli extract 2ml measures, be placed in beaker, beaker is put in 70 DEG C of water-baths and is heated, mix homogeneously is solution of additive C.
D) water 40ml being measured and is placed in beaker, beaker is put in 70 DEG C of water-baths and is heated, is aqueous solution D.
E) dissolving ethyl hydroxybenzoate 0.05g with 1,2-PD 4ml, be placed in beaker, is antiseptic solution E.
F) after oil phase A dissolves completely, add Oleum Curcumae 0.3g, Oleum menthae 0.3g is total to after hot 30s, adds aqueous solution D stirring and evenly mixing, adds alcoholic solution B and solution of additive C after 1min again, continue stirring and evenly mixing, then add 5% carboxymethylcellulose sodium solution 10g, stir, finally add antiseptic solution E and essence 0.3g, mix and pour container into, obtain promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
Embodiment 2
The preparation of 2.1 Radix Notoginseng extracting solution:
Take Radix Notoginseng appropriate, with 75% alcohol reflux three times, with 15 times of amount 75% alcohol reflux 1.5h, filter for the first time, for the second time with 10 times of amount 75% alcohol reflux 1h, filter, with 10 times of amount 75% alcohol reflux 1h, filter for the third time, three times filtrate merges, 10 times of g/ml of simmer down to medical material amount, obtain Radix Notoginseng extracting solution.
The preparation of 2.2 Flos Carthami extracts:
Take Flos Carthami appropriate, reflux, extract, twice, adds 18 times of water gagings for the first time, soaks ultrasonic 0.5h, extracts 1.5h, filters, and adds for the second time 12 times of water gagings, extracts 1h, filters, and twice filtrate merges, and 10 times of g/ml of simmer down to medical material amount, obtain Flos Carthami extract.
The preparation of 2.3 Herba Fici Simplicissimae extracting solution:
Take Herba Fici Simplicissimae appropriate, be crushed to coarse powder, reflux, extract, three times, add for the first time 15 times of water gagings, soak ultrasonic 0.5h, extract 1.5h, filter, add for the second time 12 times of water gagings, extract 1h, filter, add for the third time 11 times of water gagings, extract 1h, filter, three times filtrate merges, and 10 times of g/ml of simmer down to medical material amount, obtain Herba Fici Simplicissimae extracting solution.
The preparation of 2.4 Rhizoma Cibotii extracting solution:
Take Rhizoma Cibotii appropriate, with 60% alcohol reflux three times, with 15 times of amount 60% alcohol reflux 1.5h, filter for the first time, for the second time with 15 times of amount 60% alcohol reflux 1h, filter, with 12 times of amount 60% alcohol reflux 1h, filter for the third time, three times filtrate merges, 10 times of g/ml of simmer down to medical material amount, obtain Rhizoma Cibotii extracting solution.
The preparation of 2.5 Radix Alangii extracting solution:
Take Radix Alangii appropriate, with containing 1% tartaric 80% alcohol reflux three times, with 15 times of amount reflux, extract, 1.5h, filter for the first time, extract 1h by 12 times of amounts for the second time, filter, extract 1h by 8 times of amounts for the third time, filter, three times filtrate merges, 10 times of simmer down to medical material amounts, obtain Radix Alangii extracting solution
The preparation of 2.6 Radix Zanthoxyli extracting solution:
Take Radix Zanthoxyli appropriate, with containing 80% alcohol reflux three times, with 15 times of amount reflux, extract, 1.5h, filter for the first time, extract 1h by 10 times of amounts for the second time, filter, extract 1h by 8 times of amounts for the third time, filter, three times filtrate merges, and 10 times of simmer down to medical material amounts, obtain Radix Zanthoxyli extracting solution.
The preparation of 2.7 promoting blood circulation, removing blood stasis and relieving pain emulsifiable pastes
A) respectively by safflower oil 2g, Radix Oenotherae erythrosepalae oil 2g, house oil 2g, Oleum Hippophae 1g, azone 0.2g, multi-functional emulsifier G571g, general-purpose self emulsifying mixed emulsifier AC-4020.2-2g weighs up, and is placed in beaker, and beaker is put in 70 DEG C of water-baths and is heated, treat to melt completely, mix homogeneously is oil solution A.
B) by Borneolum Syntheticum 0.2g, Mentholum 0.2g weighs up, and dissolves and is placed in the interior alcoholic solution B of being of beaker with 75% ethanol 2ml.
C) by Radix Notoginseng extracting solution 1ml, Flos Carthami extract 1ml, Herba Fici Simplicissimae extracting solution 1.5ml, Rhizoma Cibotii extracting solution 1ml, Radix Alangii extracting solution 1.5ml, Radix Zanthoxyli extract 2ml measures, be placed in beaker, beaker is put in 70 DEG C of water-baths and is heated, mix homogeneously is solution of additive C.
D) water 35ml being measured and is placed in beaker, beaker is put in 70 DEG C of water-baths and is heated, is aqueous solution D.
E) dissolving ethyl hydroxybenzoate 0.03g with 1,2-PD 4ml, be placed in beaker, is antiseptic solution E.
F) after oil phase A dissolves completely, add Oleum Curcumae 1g, Oleum menthae 0.5g, after hot 30s, add aqueous solution D stirring and evenly mixing altogether, after 1min, add again alcoholic solution B and solution of additive C to continue stirring and evenly mixing, then add 5% sodium carboxymethyl cellulose 10g to stir, finally add antiseptic solution E and essence 0.2g, stirring and evenly mixing, obtains promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
Embodiment 3:
The physical and chemical index of embodiment 1,2 is as follows:
3.1 character
The made promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste of the present invention is faint yellow, suitable viscosity, and hardness is suitable, and mastic is evenly fine and smooth, and stretchability is good, uses rear cool and comfortable, good stability, abnormal smells from the patient is pure and fresh simple and elegant.
3.2 caloric test
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste is packaged in transparent dressing product bottle, within about one week, observes without lamination in the refrigerator cold-storages of 4 DEG C.24h in the calorstat of 55 DEG C, mastic is without the phenomenon such as layering emulsifying is spoiled.
3.3 centrifugal test
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste is packaged in to 3000r/min in tool plug test tube, and centrifugal 20min, without lamination.
3.4 room temperatures are placed experiment
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste made embodiment 1,2 is placed in to bottle for cosmetics, and room temperature leaves standstill investigates 6 months, and without lamination, unchanged with aftersensation, abnormal smells from the patient is unchanged.
3.5 irritation tests, anaphylaxis experiment
White mice back cuts off hair, smears respectively by the promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste of embodiment 1,2 preparation in cutting plucked position, and is not coated with position and compares, and there is no zest and the anaphylaxiss such as rubescent, dermexanthesis, foaming phenomenon after 30min.
Get 1 gram of embodiment and be applied in volunteer (20-66 year, 50 people) gesture and facial expression, observe after spending 30 minutes, all do not occur rubescent, dermexanthesis, foaming phenomenon.
Embodiment 4:
This promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste resultant effect is investigated
Below utilize effect of feeling to come the promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste that Evaluation operation example 1,2 produces on probation.Adopt public-opinion poll point system, choose people's object on probation of 40 25-50 year age brackets, wherein male 19 people, female 21 people, be divided into arbitrarily two groups, be applied to the blue or green sore place of the stasis of blood with it respectively with the promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste of embodiment 1,2 preparations, be one week service time, within one day, be coated with 3 times, do not have separately and with it the blue or green sore place of the stasis of blood of unction to compare.Every result of use total score is 5 points: 5 are divided into best result, represents fine, very satisfied; 4 are divided into better; 3 are divided into and can accept; 3 points is bad below, can not accept.It is below every average.The results are shown in Table 1:
Table 1 resultant effect is investigated
| Result of use | The every average of embodiment 1 | The every average of embodiment 2 |
| Invigorating blood circulation property | 4.9 | 4.9 |
| Blood stasis dispelling | 4.7 | 4.8 |
| Pain relieving | 4.8 | 4.9 |
| Refrigerant property | 5 | 5 |
| Moisture retention | 4.7 | 4.8 |
| Moistness | 4.7 | 4.7 |
| Promote wound healing | 4.8 | 4.9 |
In sum, the promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste that the present invention is made, goodlooking, suitable viscosity, hardness is suitable, and mastic is evenly fine and smooth, and stretchability is good, uses rear cool and comfortable, good stability, abnormal smells from the patient is pure and fresh simple and elegant, have well invigorate blood circulation, blood stasis dispelling, pain relieving, detumescence, promote effect of wound healing.
Claims (8)
1. a promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste, is characterized in that, 60g promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste contains following material:
2. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterized in that, described Radix Notoginseng extracting solution is prepared by the following method: take Radix Notoginseng appropriate, be ground into coarse powder, with 50%-90% alcohol reflux three times, doubly measure solvent extraction 0.5-2h with 6-18 for the first time, filter, doubly measure solvent extraction 0.5-2h with 6-12 for the second time, filter, doubly measure solvent extraction 0.5-2h with 6-12 for the third time, filter, three times filtrate merges, and 6-15 times of g/ml of volume simmer down to three seven weight of filtrate, obtains Radix Notoginseng extracting solution.
3. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, is characterized in that, described Flos Carthami extract is prepared by the following method: take Flos Carthami appropriate, reflux, extract, twice, adds 6-15 times of water gaging for the first time, soaks ultrasonic 0.5-1h, extract 0.5-2h, filter, add for the second time 6-15 times of water gaging, extract 0.5-2h, filter, twice filtrate merges, and 5-15 times of g/ml of the volume simmer down to Flos Carthami weight of filtrate, obtains Flos Carthami extract.
4. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterized in that, described Herba Fici Simplicissimae extracting solution is prepared by the following method: take Herba Fici Simplicissimae appropriate, be crushed to coarse powder, reflux, extract, three times, adds 5-15 times of water gaging for the first time, soak ultrasonic 0.5-1h, extract 0.5-2h, filter, add for the second time 5-15 times of water gaging, extract 0.5-2h, filter, add for the third time 6-12 times of water gaging, extract 0.5-2h, filter, three times filtrate merges, and 5-15 times of g/ml of the volume simmer down to Herba Fici Simplicissimae weight of filtrate, obtains Herba Fici Simplicissimae extracting solution.
5. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterized in that, described Rhizoma Cibotii extracting solution is prepared by the following method: take Rhizoma Cibotii appropriate, with 40%-80% alcohol reflux three times, doubly measure solvent extraction 0.5-2h with 8-24 for the first time, filter, doubly measure solvent extraction 0.5-2h with 8-24 for the second time, filter, doubly measure solvent extraction 0.5-2h with 6-15 for the third time, filter, three times filtrate merges, 5-15 times of g/ml of volume simmer down to Rhizoma Cibotii weight of filtrate, obtains Rhizoma Cibotii extracting solution.
6. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterized in that, described Radix Alangii extracting solution is prepared by the following method: take Radix Alangii appropriate, with containing the tartaric 40%-95% alcohol reflux of 0.5%-5% three times, doubly measure and extract 0.5-2h with 6-18 for the first time, filter, doubly measure and extract 0.5-2h with 6-12 for the second time, filter, doubly measure and extract 0.5-2h with 6-12 for the third time, filter, three times filtrate merges, 5-15 times of g/ml of volume simmer down to Radix Alangii weight of filtrate, obtains Radix Alangii extracting solution.
7. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, is characterized in that, described Radix Zanthoxyli extracting solution is prepared by the following method: take Radix Zanthoxyli appropriate, with containing 40%-95% alcohol reflux three times, doubly measure reflux, extract, 0.5-2h with 6-18 for the first time, filter, doubly measure and extract 0.5-2h with 6-18 for the second time, filter, doubly measure and extract 0.5-2h with 6-18 for the third time, filter, three times filtrate merges, 5-15 times of g/ml of volume simmer down to Radix Zanthoxyli weight of filtrate, obtains Radix Zanthoxyli extracting solution.
8. a preparation method for promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste claimed in claim 1, is characterized in that, described in comprise the following steps:
A) respectively by safflower oil 0.2-4g, Radix Oenotherae erythrosepalae oil 0.2-3g, house oil 0.2-2.5g, Oleum Hippophae 0.1-1.2g, azone 0.1-1.2g, multi-functional emulsifier G570.2-2g, general-purpose self emulsifying mixed emulsifier AC-4020.2-2g weighs up, and is placed in beaker, and beaker is put in 60 DEG C of-90 DEG C of water-baths and is heated, treat to melt completely, mix homogeneously is oil solution A.
B) by Borneolum Syntheticum 0.1-1g, Mentholum 0.1-1g weighs up, and dissolves and is placed in the interior alcoholic solution B of being of beaker with 75% ethanol 1-5ml.
C) by Radix Notoginseng extracting solution 0.5-2ml, Flos Carthami extract 0.5-2ml, Herba Fici Simplicissimae extracting solution 0.5-2ml, Rhizoma Cibotii extracting solution 1-3ml, Radix Alangii extracting solution 1-3ml, Radix Zanthoxyli extract 1-3ml measures, be placed in beaker, beaker is put in 60 DEG C of-90 DEG C of water-baths and is heated, and mix homogeneously, is solution of additive C.
D) water 25-60ml being measured and is placed in beaker, beaker is put in 60 DEG C of-90 DEG C of water-baths and is heated, is aqueous solution D.
E) dissolving ethyl hydroxybenzoate 0.01-1g with 1,2-PD 1-5ml, be placed in beaker, is antiseptic solution E.
F) after oil phase A dissolves completely, add Oleum Curcumae 0.2-1.2g, Oleum menthae 0.1-0.8g is total to after hot 20-30s, add aqueous solution D stirring and evenly mixing, after 1-2min, add again alcoholic solution B and solution of additive C to continue stirring and evenly mixing, then add 5% sodium carboxymethyl cellulose 2-10g to stir, finally add antiseptic solution E and essence 0.1-0.5g, stirring and evenly mixing, obtains promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
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Effective date of registration: 20200907 Address after: 612, building 2, Youth City State Garden, 288 Longhua Heping Road, Longhua District, Shenzhen City, Guangdong Province Patentee after: Wang Jielian Address before: 241002 Anhui, Yijiang Province Higher Education Park, Wenchang West Road, No. 22, No. Patentee before: WANNAN MEDICAL College |