CN104147533B - A kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste and preparation method thereof - Google Patents
A kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste and preparation method thereof, and following material is contained in described ointment：Safflower seed oil, evening primrose oil, house oil, hippophae rhamnoides fruit oil, oil of zedoary turmeric, peppermint oil, borneol, menthol, azone, ethanol, multi-functional emulsifier G57, general-purpose self-emulsifying mixed emulsifier AC 402, pseudo-ginseng extract solution, Flos Carthami extract, radix fici simplicissimae extract solution, scythian lamb rhizome extract solution, alangium extract solution, Radix zanthoxyli extract solution, 5% sodium carboxymethylcellulose, ethylparaben, 1,2 propane diols, water, essence.Compared with prior art, promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, in ointment bases containing pseudo-ginseng, safflower, radix fici simplicissimae, scythian lamb rhizome, alangium, Radix zanthoxyli Six-element Chinese medicine extract, promoting blood circulation, stagnation resolvation, swelling and pain relieving, clearing heat and cooling blood myogenic, blue or green treating rheumatic ostealgia, the stasis of blood, lump can be made or slightly scald, pernio etc. heal early, while there is basic maintenance function.
Description
Technical field
The present invention relates to a kind of emulsifiable paste, more particularly to a kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste and preparation method thereof.
Background technology
Treating rheumatic ostealgia disease is a kind of very high common disease of incidence of disease, is typically treated using two methods of the traditional Chinese medical science and doctor trained in Western medicine.
It is for the Itai-itai diseases western medical treatment caused by inflammation more effective, but for being induced because of factors such as wound, strain, colds
Treating rheumatic ostealgia disease, the general effect of western medical treatment is poor, and even without effect, also easily recurrence, and Western medicine usually have very big
Side effect.
The applicating history of promoting blood circulation, removing blood stasis and relieving pain Chinese medicine is long, and clinical practice is quite varied.It can not only mitigate and eliminate trouble
The pain of person and bone aching can be eliminated to a certain extent, because raising for the treatment of both principal and secondary aspect of disease is recovered rate, especially to some severes stubbornness
Property pain is evident in efficacy.With externally applied drug, to reach, analgesia is subsided a swelling, purpose promoting blood circulation and removing blood stasis, dredging collateral eliminating impediment is that China passes since ancient times
The Chinese traditional treatment method of system, it being capable of Zhi Genzhiben, thoroughly elimination ostalgia disease.
Conventional ointment has rheumatism plaster, shangshi zhitong plaster, shangshi zhitong gao etc., but these plaster have for different cases it is relatively good
Effect, but it have cure mainly the shortcomings that function is single, especially for treatment rheumatic hyperplasia caused by lumbocrural pain do not have
There is the effect of good.
The content of the invention
There is natural component extract, there is evacuate pathogenic wind to win wet, promoting blood circulationization in order to solve the above technical problems, the present invention provides one kind
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste, containing the stasis of blood, the effect removed obstruction in channels to relieve pain.
Present invention also offers a kind of preparation method of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
A kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, 60g promoting blood circulation, removing blood stasis and relieving pain emulsifiable pastes contain following material：
Described pseudo-ginseng extract solution is prepared by the following method：
It is appropriate to weigh pseudo-ginseng, is ground into coarse powder, with the extraction of 50%-90% alcohol refluxs three times, is measured for the first time with 6-18 times
Solvent extraction 0.5-2h, filtering, solvent extraction 0.5-2h is measured with 6-12 times for the second time, filter, measure solvent with 6-12 times for the third time
0.5-2h is extracted, filtering, filtrate merging three times, the volume concentration of filtrate is 6-15 times of g/ml of three seven weights, produces pseudo-ginseng and carries
Take liquid.
Described Flos Carthami extract is prepared by the following method：
It is appropriate to weigh safflower, twice, for the first time plus 6-15 times is measured water to refluxing extraction, soaks ultrasonic 0.5-1h, extracts 0.5-
2h, filtering, for the second time plus 6-15 times is measured water, is extracted 0.5-2h, is filtered, filtrate merges twice, and the volume concentration of filtrate is safflower
5-15 times of g/ml of weight, produces Flos Carthami extract.
Described radix fici simplicissimae extract solution is prepared by the following method：
It is appropriate to weigh radix fici simplicissimae, is crushed to coarse powder, three times, for the first time plus 5-15 times is measured water, immersion ultrasound to refluxing extraction
0.5-1h, 0.5-2h is extracted, filtering, for the second time plus 5-15 times is measured water, extracts 0.5-2h, filtering, and third time adds 6-12 times and measures water,
0.5-2h is extracted, filtering, filtrate merging three times, the volume concentration of filtrate is 5-15 times of g/ml of radix fici simplicissimae weight, produces five
Refer to wild peach extract solution.
Described scythian lamb rhizome extract solution is prepared by the following method：
It is appropriate to weigh scythian lamb rhizome, with the extraction of 40%-80% alcohol refluxs three times, measures solvent extraction with 8-24 times for the first time
0.5-2h, filtering, solvent extraction 0.5-2h is measured with 8-24 times for the second time, filter, measure solvent extraction 0.5- with 6-15 times for the third time
2h, filtering, filtrate merging three times, the volume concentration of filtrate is 5-15 times of g/ml of scythian lamb rhizome weight, produces scythian lamb rhizome extraction
Liquid.
Described alangium extract solution is prepared by the following method：
Weigh that alangium is appropriate, with the 40%-95% alcohol refluxs extraction of the tartaric acid containing 0.5%-5% three times, first
It is secondary to measure extraction 0.5-2h with 6-18 times, filtering, extraction 0.5-2h is measured with 6-12 times for the second time, filtering, is measured for the third time with 6-12 times
0.5-2h is extracted, filtering, filtrate merging three times, the volume concentration of filtrate is 5-15 times of g/ml of alangium weight, produces alangium
Extract solution.
Described Radix zanthoxyli extract solution is prepared by the following method：
It is appropriate to weigh Radix zanthoxyli, with the extraction of alcohol reflux containing 40%-95% three times, measures refluxing extraction with 6-18 times for the first time
0.5-2h, filtering, extraction 0.5-2h is measured with 6-18 times for the second time, filtering, is measured with 6-18 times extract 0.5-2h for the third time, filtering,
Filtrate merges three times, and the volume concentration of filtrate is 5-15 times of g/ml of Radix zanthoxyli weight, produces Radix zanthoxyli extract solution.
A kind of preparation method of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, comprises the following steps：
A) respectively by safflower seed oil 0.2-4g, evening primrose oil 0.2-3g, house oil 0.2-2.5g, hippophae rhamnoides fruit oil 0.1-1.2g,
Azone 0.1-1.2g, multi-functional emulsifier G570.2-2g, general-purpose self-emulsifying mixed emulsifier AC-4020.2-2g are weighed up, put
In in beaker, beaker is put in 60 DEG C of -90 DEG C of water-baths and heated, treats to melt completely, is well mixed as oil solution A.
B) borneol 0.1-1g, menthol 0.1-1g are weighed up, it is alcoholic solution to be placed in 75% ethanol 1-5ml dissolvings in beaker
B。
C) by pseudo-ginseng extract solution 0.5-2ml, Flos Carthami extract 0.5-2ml, radix fici simplicissimae extract solution 0.5-2ml, Cibotium barometz
Ridge extract solution 1-3ml, alangium extract solution 1-3ml, Radix Zanthoxyli extract 1-3ml are measured, are placed in beaker, beaker is put in
Heated in 60 DEG C of -90 DEG C of water-baths, be well mixed, be solution of additive C.
D) water 25-60ml is measured and be placed in beaker, beaker is put in 60 DEG C of -90 DEG C of water-baths and heated, be the aqueous solution
D。
E) with 1,2-PD 1-5ml dissolving ethylparaben 0.01-1g, it is placed in beaker, is antiseptic solution E.
F) after oil phase A is completely dissolved, oil of zedoary turmeric 0.2-1.2g is added, peppermint oil 0.1-0.8g after hot 20-30s, adds altogether
Enter aqueous solution D to stir and evenly mix, alcoholic solution B is added after 1-2min and solution of additive C continues to stir and evenly mix, then adds 5%
Sodium carboxymethylcellulose 2-10g is stirred, and is eventually adding antiseptic solution E and essence 0.1-0.5g, is stirred and evenly mixed, produces promoting blood circulationization
The stasis of blood relieves pain emulsifiable paste.
Various composition in the present invention is as follows：
Safflower seed oil is also known as safflower oil, and it is containing palmitic acid, stearic acid, oleic acid, linoleic acid, vitamin E, oryzanol, sterol
Etc. nutritional ingredient, there is preventing and treating artery sclerosis and reduce blood cholesterol levels, stimulate circulation, subside a swelling, dredge the channels, it is promoting blood circulation and removing blood stasis
Effect.Natural VE is wherein rich in, its extremely strong permeability also causes the vitamin E in safflower seed oil easily by human body
Absorb.
Evening primrose oil mainly comes from evening primrose seed.Evening primrose oil is improving skin quality, anti-aging, is promoting hair glossy,
Blood pressure is adjusted, improves blood circulation, is promoting blood circulation and removing obstruction in channels, detumescence, sore, anti-inflammatory etc. have extensive medical, medical value.It can
Wound healing is helped, contributes to the joint of maintaining healthy and prevents the inflammation symptom of other tissues, help to treat eczema, skin
Scorching, this kind of skin disease of wind dampness rheumatic anesthesia pain, the inflammation such as rheumatic arthritis, ulcer section enteritis, gastritis are eliminated, improve multiple vertebra
Inflammation symptom caused by inflammation, lupus erythematosus etc..
House oil contains abundant natural nutrient, highly unsaturated fatty acid and vitamin e, and permeability is strong, can promote people
Body vis medicatrix naturae and metabolism.House oil is good to affinity, the stretchability of skin, is particularly useful to eczema, scald, brings disgrace to the extensive of sore
It is multiple.
General flavone can increase cardiac muscle nutritional blood flow in hippophae rhamnoides fruit oil, improve Myocardial Microcirculation, preferably improve cardiac muscle
Blood supply state, inhibition thrombosis, there is promoting blood circulation to remove blood stasis, contributes to the recovery of traumatic injury.
Peppermint oil contains abundant menthol, plays the role of anti-inflammatory, analgesia, cooling skin, its refrigerant sensation, can shrink
Capilary, releive itch, inflammation and the skin burnt.Peppermint oil treatment mild skin itch, inflammation of releiving, redness can be used
Skin, analgesic.
Menthol has a special aroma of peppermint, refrigerant after scorching hot at the beginning of taste, can optionally stimulate human body skin or mucous membrane
Frigidoreceptor, produce sense of cold reflection and creeping chill.External application can be relieved pain with anti-inflammatory, antipruritic, be stimulated circulation, and mitigate edema etc.；
Take orally so that local inflammation (sphagitis) can be alleviated in compound preparation.
Pseudo-ginseng has significant promoting blood circulation and removing blood stasis, detumescence ding-tong effect, there is " invaluable ", the good reputation of " southern part of the country god's grass ".Due to
Pseudo-ginseng is all panax species, and its effective active matter is higher than and more than ginseng, therefore again by modern Chinese herbal medicine materia medica
Family is referred to as " king in ginseng ".Major function hemostasis stasis, detumescence ding-tong, hemostasis is flutterred for falling, traumatism and bleeding, carbuncle swells pain.
Oil of zedoary turmeric is used for back pain of limbs, nameless sores or boils, traumatic injury, scalds and burns, snakeworm scorpion dog centipede wound, wound and gone out
Blood etc..This product blood-breaking, Xiao Ji Zhi Tong, dissolving stasis.
The similar camphor of borneol swelling and pain relieving effect, there are heat-clearing, antipruritic, analgesic, antisepsis, available for neuralgia and disappear
It is scorching.
Safflower invigorate blood circulation, blood stasis removing analgesic, have a pain suitable for hemostasis, carbuncle swells, traumatic injury, various varication, tip
Neuritis, lower limb numbness or the hemostasis disease such as livid purple.
Radix fici simplicissimae has the work(of dampness removing relaxing muscles and tendons, and psoralen is its main active, for diseases such as arthralgia pain due to rheumatism.
Scythian lamb rhizome category strong muscles and bones medicine, there is the double action for the treatment of and health care to the disease that muscles and bones is not good for.Cure mainly spinal column
Strong pain, it is impossible to pitching, the disease such as sufficient knee weakness and lumbago due to wind-wetness evil.
Alangium promoting blood circulation to remove blood stasis, energy dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, blood stasis removing analgesic, for arthralgia pain due to rheumatism, numb limb, falls
Play damage；Leaf is used for injury and bone fracture, knife wound bleeding.
Radix zanthoxyli can dissipate that the stasis of blood is active, wind-dispelling removing toxic substances.Major function：Promoting qi circulation and relieving pain, promoting blood circulation and removing blood stasis, dispelling wind and removing obstruction in the meridians.For gas
Traumatic injury, arthralgia pain due to rheumatism, stomachache, toothache caused by stagnant blood stasis, venomous snake bite, control scald outside.
Substantial amounts of rare Chinese medicine extract component is with the addition of in this promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste prescription.All medicines share, it is common to rise
The effect of to promoting blood circulation and stopping pain, channels sootheing and network vessel quickening.
Compared with the prior art, promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste provided by the invention, in ointment bases containing pseudo-ginseng, safflower,
Radix fici simplicissimae, scythian lamb rhizome, alangium, the extract of Radix zanthoxyli Six-element Chinese medicine, promoting blood circulation, stagnation resolvation, swelling and pain relieving, clearing heat and cooling blood life
Flesh, blue or green treating rheumatic ostealgia, the stasis of blood, lump can be made or slightly scald, pernio etc. heal early, while there is basic maintenance function.This hair
It is bright that cream is made in medicine, it is easy to use and carries；Emulsifiable paste is in faint yellow, and viscosity is suitable, and hardness is suitable, and lotion is fine and smooth
Even, stretchability is good, and with rear cool and comfortable, stability is good, and smell is pure and fresh simple and elegant.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
The preparation of 1.1 pseudo-ginseng extract solutions：
Pseudo-ginseng 200g is weighed, with the extraction of 75% alcohol reflux three times, for the first time with 10 times of amount 75% ethanol extraction 1.5h, mistake
Filter, 75% ethanol extraction 1h are measured with 8 times for the second time, filtering, 1h is extracted with 8 times of 75% ethanol of amount for the third time, filters, three times filtrate
Merge, concentrate as 10 times of g/ml of medicinal material amount, produce pseudo-ginseng extract solution.
The preparation of 1.2 Flos Carthami extracts：
Safflower 50g is weighed, twice, for the first time plus 10 times are measured water to refluxing extraction, are soaked ultrasonic 0.5h, are extracted 1.5h, filter,
Second plus 8 times of amount water, extract 1h, filtering, twice filtrate merge, concentrate as 10 times of g/ml of medicinal material amount, produce Flos Carthami extract.
The preparation of 1.3 radix fici simplicissimae extract solutions：
Radix fici simplicissimae 100g is weighed, is crushed to coarse powder, three times, for the first time plus 10 times of amount water, immersion are ultrasonic for refluxing extraction
0.5h, 1.5h is extracted, filtered, second plus 8 times of amount water, extracted 1h, filter, third time plus 8 times of amount water, extracted 1h, filter, three
Secondary filtrate merges, and concentrates as 10 times of g/ml of medicinal material amount, produces radix fici simplicissimae extract solution.
The preparation of 1.4 scythian lamb rhizome extract solutions：
It is appropriate to weigh scythian lamb rhizome, with the extraction of 60% alcohol reflux three times, is carried for the first time with 20 times of 60% alcohol refluxs of amount
1.5h is taken, is filtered, for the second time with 15 times of amount 60% alcohol refluxs extraction 1h, filtering, for the third time with 10 times of 60% alcohol refluxs of amount
Extract 1h, filtering, three times filtrate merge, be concentrated under reduced pressure as 10 times of g/ml of medicinal material amount, produce scythian lamb rhizome extract solution.
The preparation of 1.5 alangium extract solutions：
Alangium 200g is weighed, it is with the 80% alcohol reflux extraction containing 1% tartaric acid three times, molten with 10 times of amounts for the first time
Agent refluxing extraction 1.5h, filtering, for the second time with 8 times of amount solvent refluxings extraction 1h, filtering, carried for the third time with 8 times of amount solvent refluxings
1h is taken, is filtered, filtrate merges three times, concentrates as 10 times of g/ml of medicinal material amount, produces alangium extract solution.
The preparation of 1.6 Radix zanthoxyli extract solutions：
Radix zanthoxyli 300g is weighed, three times, is extracted for the first time with 10 times of amount solvent refluxings with containing the extraction of 80% alcohol reflux
1.5h, filterings, solvent refluxings extraction 1h are measured with 8 times for the second time, filtering, 1h is extracted with 8 times of amount solvent refluxings for the third time, filters,
Filtrate merges three times, concentrates as 10 times of g/ml of medicinal material amount, produces Radix zanthoxyli extract solution.
The preparation of 1.7 promoting blood circulation, removing blood stasis and relieving pain emulsifiable pastes
A) divide safflower seed oil 3g, evening primrose oil 3g, house oil 2g, hippophae rhamnoides fruit oil 0.2g, azone 0.2g, multi-functional emulsifier
G570.3g, general-purpose self-emulsifying mixed emulsifier AC-4020.3g are weighed up, are placed in beaker, beaker is put in 70 DEG C of water-baths
Heating, treats to melt completely, is well mixed as oil solution A.
B) borneol 0.2g, menthol 0.2g are weighed up, it is alcoholic solution B to be placed in 75% ethanol 2ml dissolvings in beaker.
C) by pseudo-ginseng extract solution 2ml, Flos Carthami extract 2ml, radix fici simplicissimae extract solution 2ml, scythian lamb rhizome extract solution 2ml,
Alangium extract solution 2ml, Radix Zanthoxyli extract 2ml is measured, is placed in beaker, beaker is put in 70 DEG C of water-baths and heated, mixed
Close is uniformly solution of additive C.
D) water 40ml is measured and be placed in beaker, beaker is put in 70 DEG C of water-baths and heated, be aqueous solution D.
E) with 1,2-PD 4ml dissolving ethylparaben 0.05g, it is placed in beaker, is antiseptic solution E.
F) after oil phase A is completely dissolved, oil of zedoary turmeric 0.3g is added, peppermint oil 0.3g after hot 30s, adds aqueous solution D and stirred altogether
Mixing is mixed, alcoholic solution B and solution of additive C are added after 1min, continues to stir and evenly mix, then adds 5% carboxymethyl cellulose
Sodium solution 10g, stirring, antiseptic solution E and essence 0.3g are eventually adding, container is poured into mixing, produces promoting blood circulation, removing blood stasis and relieving pain breast
Cream.
Embodiment 2
The preparation of 2.1 pseudo-ginseng extract solutions：
It is appropriate to weigh pseudo-ginseng, with the extraction of 75% alcohol reflux three times, is extracted for the first time with 15 times of 75% alcohol refluxs of amount
1.5h, filtering, for the second time with 10 times of amount 75% alcohol refluxs extraction 1h, filtering, carried for the third time with 10 times of 75% alcohol refluxs of amount
1h is taken, is filtered, filtrate merges three times, concentrates as 10 times of g/ml of medicinal material amount, produces pseudo-ginseng extract solution.
The preparation of 2.2 Flos Carthami extracts：
It is appropriate to weigh safflower, twice, for the first time plus 18 times are measured water to refluxing extraction, are soaked ultrasonic 0.5h, are extracted 1.5h, mistake
Filter, second plus 12 times of amount water, extract 1h, filtering, twice filtrate merge, concentrate as 10 times of g/ml of medicinal material amount, produce safflower and carry
Take liquid.
The preparation of 2.3 radix fici simplicissimae extract solutions：
It is appropriate to weigh radix fici simplicissimae, is crushed to coarse powder, three times, for the first time plus 15 times of amount water, immersion are ultrasonic for refluxing extraction
0.5h, 1.5h is extracted, filtered, second plus 12 times of amount water, extracted 1h, filter, third time plus 11 times of amount water, extracted 1h, filter,
Filtrate merges three times, concentrates as 10 times of g/ml of medicinal material amount, produces radix fici simplicissimae extract solution.
The preparation of 2.4 scythian lamb rhizome extract solutions：
It is appropriate to weigh scythian lamb rhizome, with the extraction of 60% alcohol reflux three times, is carried for the first time with 15 times of 60% alcohol refluxs of amount
1.5h is taken, is filtered, for the second time with 15 times of amount 60% alcohol refluxs extraction 1h, filtering, for the third time with 12 times of 60% alcohol refluxs of amount
Extract 1h, filtering, three times filtrate merge, concentrate as 10 times of g/ml of medicinal material amount, produce scythian lamb rhizome extract solution.
The preparation of 2.5 alangium extract solutions：
Weigh that alangium is appropriate, with the 80% alcohol reflux extraction containing 1% tartaric acid three times, measured back for the first time with 15 times
Stream extraction 1.5h, filtering, measured with 12 times extract 1h for the second time, filtering, for the third time with 8 times of amount extraction 1h, filtered, filtrate is closed three times
And concentrate as 10 times of medicinal material amount, produce alangium extract solution
The preparation of 2.6 Radix zanthoxyli extract solutions：
It is appropriate to weigh Radix zanthoxyli, three times, refluxing extraction 1.5h, mistake are measured with 15 times for the first time with containing the extraction of 80% alcohol reflux
Filter, for the second time with 10 times of amount extraction 1h, filtering, for the third time with 8 times of amount extraction 1h, filtering, filtrate merging, is concentrated as medicinal material three times
10 times of amount, produces Radix zanthoxyli extract solution.
The preparation of 2.7 promoting blood circulation, removing blood stasis and relieving pain emulsifiable pastes
A) respectively by safflower seed oil 2g, evening primrose oil 2g, house oil 2g, hippophae rhamnoides fruit oil 1g, azone 0.2g, multi-functional emulsifier
G571g, general-purpose self-emulsifying mixed emulsifier AC-4020.2-2g are weighed up, are placed in beaker, beaker is put in 70 DEG C of water-baths
Heating, treats to melt completely, is well mixed as oil solution A.
B) borneol 0.2g, menthol 0.2g are weighed up, it is alcoholic solution B to be placed in 75% ethanol 2ml dissolvings in beaker.
C) by pseudo-ginseng extract solution 1ml, Flos Carthami extract 1ml, radix fici simplicissimae extract solution 1.5ml, scythian lamb rhizome extract solution
1ml, alangium extract solution 1.5ml, Radix Zanthoxyli extract 2ml are measured, are placed in beaker, beaker is put in 70 DEG C of water-baths plus
Heat, it is well mixed as solution of additive C.
D) water 35ml is measured and be placed in beaker, beaker is put in 70 DEG C of water-baths and heated, be aqueous solution D.
E) with 1,2-PD 4ml dissolving ethylparaben 0.03g, it is placed in beaker, is antiseptic solution E.
F) after oil phase A is completely dissolved, oil of zedoary turmeric 1g, peppermint oil 0.5g are added, altogether after hot 30s, adds aqueous solution D stirrings
Mix, add alcoholic solution B after 1min and solution of additive C continues to stir and evenly mix, then add 5% sodium carboxymethylcellulose
10g is stirred, and is eventually adding antiseptic solution E and essence 0.2g, is stirred and evenly mixed, produces promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste.
Embodiment 3：
The physical and chemical index of embodiment 1,2 is as follows：
3.1 character
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste made by the present invention is in faint yellow, and viscosity is suitable, and hardness is suitable, and lotion is fine and smooth
Even, stretchability is good, and with rear cool and comfortable, stability is good, and smell is pure and fresh simple and elegant.
3.2 caloric test
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste is packaged in transparence cosmetic bottle, in 4 DEG C of one week or so observation nothing of refrigerator cold-storage
Lamination.In 24h in 55 DEG C of insulating box, lotion emulsifies phenomena such as spoiled without layering.
3.3 centrifugal test
Promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste is packaged in 3000r/min in tool plug test tube, centrifuges 20min, no lamination.
3.4 room temperatures place experiment
The made promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste of embodiment 1,2 is placed in bottle for cosmetics, is stored at room temperature investigation 6 months, nothing
Lamination, feel unchanged after, smell is unchanged.
3.5 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, and it is plucked in cutting to smear the promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste prepared by embodiment 1,2 respectively
Position, and do not apply position and be compared, there is no the excitants such as rubescent, dermexanthesis, foaming phenomena and allergic reaction after 30min.
1 gram of Example is applied in volunteer (20-66 year, 50 people) gesture and facial expression, is observed after spending 30 minutes, is not sent out
It is red, dermexanthesis, foaming phenomena.
Embodiment 4：
The promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste resultant effect is investigated
Following with probation the effect of feeling to evaluate promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste that embodiment 1,2 produces.Using the people
Meaning investigation point system, the people of 40 25-50 year age brackets is chosen as object on probation, wherein male 19 people, the people of female 21, any decile
Into two groups, respectively with embodiment 1,2 prepare promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste be applied to stasis of blood green grass or young crops sore place, usage time one
In week, apply 3 times within one day, each compared with the stasis of blood green grass or young crops sore place not applied the ointment with it.Every using effect total score is 5 points：5 points are
Best result, represent fine, it is very satisfied；4 points are preferable；3 points are to receive；Less than 3 points are bad, it is impossible to are received.Below
For every average.It the results are shown in Table 1：
The resultant effect of table 1 is investigated
| Using effect | 1 every average of embodiment | 2 every average of embodiment |
| Promoting blood circulation property | 4.9 | 4.9 |
| Stagnation resolvation | 4.7 | 4.8 |
| It is analgesic | 4.8 | 4.9 |
| It is cooling | 5 | 5 |
| Moisture retention | 4.7 | 4.8 |
| Moistness | 4.7 | 4.7 |
| Promote wound healing | 4.8 | 4.9 |
In summary, the made promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste of the present invention, goodlooking, viscosity is suitable, and hardness is suitable, lotion
Fine and smooth uniformly stretchability is good, and with rear cool and comfortable, stability is good, and smell is pure and fresh simple and elegant, has good promoting blood circulation, stagnation resolvation, stops
Bitterly, subside a swelling, promote wound healing the effect of.
Claims (7)
1. a kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste, it is characterised in that 60g promoting blood circulation, removing blood stasis and relieving pain emulsifiable pastes contain following material：
The preparation method of described promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste, comprises the following steps：
A) respectively by safflower seed oil 0.2-4g, evening primrose oil 0.2-3g, house oil 0.2-2.5g, hippophae rhamnoides fruit oil 0.1-1.2g, azone
0.1-1.2g, multi-functional emulsifier G57 0.2-2g, general-purpose self-emulsifying mixed emulsifier AC-402 0.2-2g are weighed up, are placed in
In beaker, beaker is put in 60 DEG C of -90 DEG C of water-baths and heated, treats to melt completely, is well mixed as oil solution A；
B) borneol 0.1-1g, menthol 0.1-1g are weighed up, it is alcoholic solution B to be placed in 75% ethanol 1-5ml dissolvings in beaker；
C) pseudo-ginseng extract solution 0.5-2ml, Flos Carthami extract 0.5-2ml, radix fici simplicissimae extract solution 0.5-2ml, scythian lamb rhizome are carried
Liquid 1-3ml, alangium extract solution 1-3ml are taken, Radix zanthoxyli extract solution 1-3ml is measured, is placed in beaker, and beaker is put in 60
Heated in DEG C -90 DEG C of water-baths, be well mixed, be solution of additive C；
D) water 25-60ml is measured and be placed in beaker, beaker is put in 60 DEG C of -90 DEG C of water-baths and heated, be aqueous solution D；
E) with 1,2-PD 1-5ml dissolving ethylparaben 0.01-1g, it is placed in beaker, is antiseptic solution E；
F) after oil solution A is completely dissolved, oil of zedoary turmeric 0.2-1.2g is added, peppermint oil 0.1-0.8g after hot 20-30s, is added altogether
Aqueous solution D is stirred and evenly mixed, and alcoholic solution B is added after 1-2min and solution of additive C continues to stir and evenly mix, then adds 5% carboxylic
Sodium carboxymethylcellulose pyce 2-10g is stirred, and is eventually adding antiseptic solution E and essence 0.1-0.5g, is stirred and evenly mixed, produces promoting blood circulation and removing blood stasis
Relieve pain emulsifiable paste.
2. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterised in that described pseudo-ginseng extract solution passes through following
It is prepared by method：It is appropriate to weigh pseudo-ginseng, is ground into coarse powder, with the extraction of 50%-90% alcohol refluxs three times, is measured for the first time with 6-18 times
Solvent extraction 0.5-2h, filtering, solvent extraction 0.5-2h is measured with 6-12 times for the second time, filter, measure solvent with 6-12 times for the third time
0.5-2h is extracted, filtering, filtrate merging three times, the volume concentration of filtrate is 6-15 times of g/ml of three seven weights, produces pseudo-ginseng and carries
Take liquid.
3. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterised in that described Flos Carthami extract passes through following
It is prepared by method：It is appropriate to weigh safflower, twice, for the first time plus 6-15 times is measured water to refluxing extraction, soaks ultrasonic 0.5-1h, extracts 0.5-
2h, filtering, for the second time plus 6-15 times is measured water, is extracted 0.5-2h, is filtered, filtrate merges twice, and the volume concentration of filtrate is safflower
5-15 times of g/ml of weight, produces Flos Carthami extract.
4. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterised in that described radix fici simplicissimae extract solution passes through
It is prepared by following methods：It is appropriate to weigh radix fici simplicissimae, is crushed to coarse powder, three times, for the first time plus 5-15 times is measured water to refluxing extraction, is soaked
Ultrasonic 0.5-1h, 0.5-2h is extracted, filtering, for the second time plus 5-15 times is measured water, extracts 0.5-2h, filtering, and third time adds 6-12 times
Water is measured, extracts 0.5-2h, filtering, filtrate merging three times, the volume concentration of filtrate is 5-15 times of g/ml of radix fici simplicissimae weight, i.e.,
Obtain radix fici simplicissimae extract solution.
5. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterised in that described scythian lamb rhizome extract solution passes through
It is prepared by following methods：It is appropriate to weigh scythian lamb rhizome, with the extraction of 40%-80% alcohol refluxs three times, is measured for the first time with 8-24 times molten
0.5-2h is extracted in agent, filtering, measures solvent extraction 0.5-2h with 8-24 times for the second time, is filtered, is measured solvent with 6-15 times for the third time and carry
0.5-2h is taken, is filtered, filtrate merges three times, and the volume concentration of filtrate is 5-15 times of g/ml of scythian lamb rhizome weight, produces Cibotium barometz
Ridge extract solution.
6. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterised in that described alangium extract solution by with
It is prepared by lower section method：Weigh that alangium is appropriate, with the 40%-95% alcohol refluxs extraction of the tartaric acid containing 0.5%-5% three times, the
Extraction 0.5-2h once is measured with 6-18 times, filtering, measures extraction 0.5-2h, filtering, for the third time with 6-12 times with 6-12 times for the second time
Amount extraction 0.5-2h, filtering, filtrate merging three times, the volume concentration of filtrate is 5-15 times of g/ml of alangium weight, produces anise
Maple extract solution.
7. promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste according to claim 1, it is characterised in that described Radix zanthoxyli extract solution by with
It is prepared by lower section method：It is appropriate to weigh Radix zanthoxyli, with the extraction of alcohol reflux containing 40%-95% three times, measures backflow with 6-18 times for the first time
0.5-2h is extracted, filtering, extraction 0.5-2h is measured with 6-18 times for the second time, filtering, measures extraction 0.5-2h, mistake with 6-18 times for the third time
Filter, filtrate merging three times, the volume concentration of filtrate is 5-15 times of g/ml of Radix zanthoxyli weight, produces Radix zanthoxyli extract solution.
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