CN102233006A - Compound Chinese medicinal extract for treating acne and application thereof - Google Patents
Compound Chinese medicinal extract for treating acne and application thereof Download PDFInfo
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- CN102233006A CN102233006A CN2011100488702A CN201110048870A CN102233006A CN 102233006 A CN102233006 A CN 102233006A CN 2011100488702 A CN2011100488702 A CN 2011100488702A CN 201110048870 A CN201110048870 A CN 201110048870A CN 102233006 A CN102233006 A CN 102233006A
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Abstract
The invention discloses a compound Chinese medicinal extract for treating acne and application thereof. The compound Chinese medicinal extract comprises the following components in percentage by weight: 10-50 percent of cortex magnolia officinalis extract (magnolol and honokiol), 10-50 percent of common cnidium fruit extract, 10-50 percent of danshen root extract and 10-50 percent of weeping forsythia. The compound Chinese medicinal extract can be used for solution, suspending liquid, emulsion, cream, ointment, gelatin, milky fluid, skin moisturizer, powder, soap, oil, dry powder, foundation emulsion, wet powder or spray. The compound Chinese medicinal extract has the efficacies of diminishing inflammation, detoxicating, sterilizing, invigorating blood circulation, removing blood stasis and the like, as well as enabling the blood at the affected parts of patients to circularly smoothen, removing blood stasis and removing the acne or acne scars.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of herbal mixture extract and application thereof that is used for the treatment of acne.
Background technology
Acne is a kind of chronic inflammatory diseases of pilosebaceous unit structure, mainly occurs in face and thoracic dorsal place, shows as blackhead, inflammatory pimple, Secondary cases pustule or tuberosity, cyst etc.The traditional Chinese medical science is called " rosacea caused by lung-wind ", " pimples ", and it is strongly fragrant in local face mostly to be affection of exogenous wind-cold, wind heat, rheumatism, and strongly fragrant fire-transformation of a specified duration causes blockage of main and collateral channels, and the expectorant blood coagulation stasis of blood generates acne.Strongly fragrant suppuration of a specified duration just can generate skin sore, pathogen usually intruding into collateral in protracted disease, and lump formation due to accumulation of pathogens, or damage face skin then becomes tuberosity, cicatrix excessively for a long time.In addition, the plain body sun of patient heat is contained partially, and the pungent greasy food of surfeit makes damp and hot amassing in gastrointestinal in addition, and gastrointestinal is damp and hot can not be assigned, and superinverse is steamed in lung on the contrary, accumulates and hinders in face, the sick expectorant of giving birth to for a long time, and the tired stasis of blood is tied skin mutually and is formed.
The medicine for external use that now is used for the treatment of acne on the market all contains A acid composition mostly, as Viaminate dimension E ointment, mainly is coming off of accelerometer cornu cutaneum matter, keeps the drying of skin, thus the treatment acne.But after being to use such product, skin is peeled easily, and can not touch sunlight, thereby can not use by day.And anemia of pregnant woman's use can have in addition and can influence fetal development, causes teratogenesis.
Some natural plants Chinese crude drugs because effects such as its distinctive eliminating inflammation and expelling toxins, stopping bleeding and removing blood stasis, and have safely, have no side effect, the advantage little to skin irritation, its extract has begun to be used in to prevent and treat in the acne.Occurred many relevant prevent and treat combination of acne Chinese medicine extract and application in recent years, many relevant patents also occur, and various Chinese medicine composition has been not quite similar also.But it is the Chinese medicine composition invention of material that Shang Weijian has with Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract.
Summary of the invention
This present invention will provide a kind of herbal mixture extract and application thereof that is used for the treatment of acne at the problems referred to above.
The present invention comprises Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract.Main functional component in the Cortex Magnoliae Officinalis is a magnolol, has antiinflammatory, and is antibiotic, resisting pathogenic microbes, antiulcer, pharmacological actions such as antioxidation; Fructus Cnidii dispels the wind, antibacterial action; Tanshinone IIA in the Radix Salviae Miltiorrhizae, to removing from office blue formula positive bacteria the obvious suppression effect is arranged, corynebacterium acnes also there is stronger inhibitory action, and estrogen-like effects with antiandrogen effect and gentleness, its water-soluble composition danshensu cellular immunization has inhibitory action simultaneously, participates in the immune link of acne; But Fructus Forsythiae extract inhibiting bacteria and diminishing inflammation, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.
Technical scheme is as follows:
A kind of herbal mixture extract that is used for the treatment of acne comprises Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract, component percentages as follows:
Cortex Magnoliae Officinalis extract (magnolol, honokiol) 10-50%
Fructus cnidii extract 10-50%
Radix Salviae Miltiorrhizae extract 10-50%
Fructus Forsythiae extract 10-50%
The extracting method of above-mentioned Chinese medicine extract, leaching process are all unqualified.For example can adopt solvent extraction method, solvent is water, ultrasonic extraction, supercritical extraction etc.
The cooperation consumption that is used for the treatment of the herbal mixture extract of acne of the present invention is counted 0.05-20% (w/w) with dry thing, and preferable amount is 0.1-5% (w/w).
The dosage form that the present invention uses is not particularly limited, and can be solution, suspension, emulsion, cream, paste, gel, milk, skin care liquid, powder, fancy soap, oil, dry powder, foundation emulsion, wet-milling or spray.
Beneficial effect of the present invention: effects such as the combination of the compound recipe of above-mentioned Chinese medicine has antiinflammatory, detoxifcation, sterilizes, invigorates blood circulation, clots absorbing blood, make patient's affected part blood circulation unimpeded, blood stasis removing blood etc., thus reach the purpose of eliminating acne and acne scars.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.But technical scope of the present invention is not subjected to the qualification of these embodiment.
Embodiment 1
Chinese medicine composition extract of the present invention is used to prepare the cream for the treatment of acne, its prescription is in 100 parts wherein: 3 parts of Cortex Magnoliae Officinalis extracts (magnolol, honokiol), 1 part of Fructus cnidii extract, 1 part of Radix Salviae Miltiorrhizae extract, 1 part of Fructus Forsythiae extract, 3.0 parts of monoethylene glycol, 3.0 parts in vaseline, 3.0 parts of dimethicones, 2.0 parts of glycerol, mix 5.0 parts of alcohol, 8.0 parts of white oils, 22.0 parts of 1,3 butylene glycols, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: earlier with 1,3 butylene glycol and part deionization mix homogeneously; With white oil, vaseline, monoethylene glycol, mix alcohol, dimethicone is even 75 ℃ of-80 ℃ of stirring and dissolving; With above two kinds of mixture suction successively emulsifying pot, homogenizing 5 minutes stirs and is cooled to 40 ℃, adds Cortex Magnoliae Officinalis extract, Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract, stirs evenly, and is cooled to room temperature and gets final product.
Embodiment 2
Herbal mixture extract of the present invention is used to prepare the gel for the treatment of acne, its prescription in 100 parts wherein: 2.5 parts of Cortex Magnoliae Officinalis extracts (magnolol, honokiol), 2.0 parts of Fructus cnidii extracts, 1.25 parts of Radix Salviae Miltiorrhizae extracts, 1.0 parts of Fructus Forsythiae extracts, 1.0 parts of carbopol 940,10.0 parts of propylene glycol, oleyl alcohol ether-20 1.5 part, 2.0 parts of triethanolamine, EDTA-Na20.1 part, antiseptic are an amount of, all the other are deionized water (being added to 100 parts).
Concrete technological process is: under quick condition of stirring, carbopol 940 is sprinkled into the part deionized water lentamente, makes dissolving fully, with residue deionized water dissolving propylene glycol and antiseptic; With the mixture suction vacuum emulsification jar of carbopol 940 and deionized water, deionized water, propylene glycol and antiseptic are filtered in the adding vacuum emulsification jar again, 75 ℃-80 ℃, stir vacuumize degassing; After above mixture dissolves the uniform mixing component that adds oleyl alcohol ether and Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract when complete, after continuing to stir evenly, add the triethanolamine neutralization, the while evacuation, outgasing to product does not have bubble, is cooled to room temperature and gets final product.
Embodiment 3
Herbal mixture extract of the present invention is used to prepare the emulsion for the treatment of acne, its prescription is in 100 parts wherein: 15 parts of Cortex Magnoliae Officinalis extracts (magnolol, honokiol), 5 parts of Fructus cnidii extracts, 3.5 parts of Radix Salviae Miltiorrhizaes, 2.0 parts of Fructus Forsythiaes, 4.0 parts of monoglycerides, 2.0 parts in vaseline, 4.0 parts of dimethicones, 5.0 parts of glycerol, mix that 15.0 parts of alcohol, 7.0 parts of white oils, 16.0 parts of 1,3 butylene glycols, 0.5 part of carbopol 940, triethanolamine are transferred PH5-7, antiseptic vector in right amount, all the other are deionized water (being added to 100 parts).
Concrete technological process is: use 1,3 butylene glycol and part deionized water dissolving Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract earlier, filter stand-by; White oil, vaseline, monoglyceride, mixed alcohol, dimethicone stir for 75 ℃-80 ℃; Residue deionized water, glycerol, carbopol 940, antiseptic stirs for 75 ℃-80 ℃; With above two kinds of mixture suction successively emulsifying pot, homogenizing 3 minutes adds triethanolamine and transfers PH5-7 in right amount; Stirring is cooled to 40 ℃, adds to filter good Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract, stirs evenly, and is cooled to room temperature and gets final product.
Claims (4)
1. a herbal mixture extract and application thereof that is used for the treatment of acne, it is characterized in that: comprise Cortex Magnoliae Officinalis extract (magnolol, honokiol), Fructus cnidii extract, Radix Salviae Miltiorrhizae extract, Fructus Forsythiae extract, and the percentage by weight of arbitrary component all is no more than 50% of total amount.
2. a kind of herbal mixture extract and application thereof that is used for the treatment of acne according to claim 1 is characterized in that: component percentages as follows: Cortex Magnoliae Officinalis extract (magnolol, honokiol) 10-50%, Fructus cnidii extract 10-50%, Radix Salviae Miltiorrhizae extract 10-50%, Fructus Forsythiae extract 10-50%.
3. a kind of herbal mixture extract and application thereof that is used for the treatment of acne according to claim 1 is characterized in that: cooperate consumption to count 0.05-20% (w/w) with dry thing, preferable amount is 0.1-5% (w/w).
4. a kind of herbal mixture extract and application thereof that is used for the treatment of acne according to claim 1, it is characterized in that: the applicable dosage form of the present invention is not particularly limited, and can be solution, suspension, emulsion, cream, paste, gel, milk, skin care liquid, powder, fancy soap, oil, dry powder, foundation emulsion, wet-milling or spray.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100488702A CN102233006A (en) | 2011-03-01 | 2011-03-01 | Compound Chinese medicinal extract for treating acne and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011100488702A CN102233006A (en) | 2011-03-01 | 2011-03-01 | Compound Chinese medicinal extract for treating acne and application thereof |
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| CN102233006A true CN102233006A (en) | 2011-11-09 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816260A (en) * | 2012-11-16 | 2014-05-28 | 丁徽 | Traditional Chinese medicine for treating internal and external hemorrhoids |
| CN105381035A (en) * | 2015-11-13 | 2016-03-09 | 威海人生药业集团股份有限公司 | Pharmaceutical composition for removing scars and preparation method thereof |
| CN106074578A (en) * | 2016-07-06 | 2016-11-09 | 南方医科大学 | A kind of pharmaceutical composition treating acne and application thereof |
| CN107596360A (en) * | 2017-10-10 | 2018-01-19 | 苏州浔宇新材料科技有限公司 | A kind of pharmaceutical composition for repairing scar and preparation method thereof |
| CN112972436A (en) * | 2021-02-26 | 2021-06-18 | 西安文森医药科技有限公司 | Application of magnolol, honokiol and derivatives thereof in preparation of scar treatment medicines and medicine composition |
-
2011
- 2011-03-01 CN CN2011100488702A patent/CN102233006A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816260A (en) * | 2012-11-16 | 2014-05-28 | 丁徽 | Traditional Chinese medicine for treating internal and external hemorrhoids |
| CN105381035A (en) * | 2015-11-13 | 2016-03-09 | 威海人生药业集团股份有限公司 | Pharmaceutical composition for removing scars and preparation method thereof |
| CN106074578A (en) * | 2016-07-06 | 2016-11-09 | 南方医科大学 | A kind of pharmaceutical composition treating acne and application thereof |
| CN106074578B (en) * | 2016-07-06 | 2019-03-05 | 南方医科大学 | A kind of pharmaceutical composition and its application for treating acne |
| CN107596360A (en) * | 2017-10-10 | 2018-01-19 | 苏州浔宇新材料科技有限公司 | A kind of pharmaceutical composition for repairing scar and preparation method thereof |
| CN112972436A (en) * | 2021-02-26 | 2021-06-18 | 西安文森医药科技有限公司 | Application of magnolol, honokiol and derivatives thereof in preparation of scar treatment medicines and medicine composition |
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Application publication date: 20111109 |