CN104983065B - Electron aerosolization liquid with human body function nursing effect - Google Patents
Electron aerosolization liquid with human body function nursing effect Download PDFInfo
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- CN104983065B CN104983065B CN201510495473.8A CN201510495473A CN104983065B CN 104983065 B CN104983065 B CN 104983065B CN 201510495473 A CN201510495473 A CN 201510495473A CN 104983065 B CN104983065 B CN 104983065B
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- human body
- electronic cigarette
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
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Abstract
The invention provides electron aerosolization liquid with a human body function nursing effect. The electron aerosolization liquid comprises, by weight, the components of 0.05％-2.6％ parts of natural nicotine, 3％-18％ of tobacco absolute oil, 0.1％-0.5％ of taurine, 0.05％-0.1％ of asparaginic acid, 0.03％-0.08％ of isoleucine, 0.4％-5％ of hawthorn tincture, 0.5％-5％ of folium artemisiae argyi extract, 26％-50％ of USP-grade glycerinum and the balance food-grade propylene glycol. Damage to a human body from nicotine is lowered, meanwhile, body health can be well achieved, and the human body function nursing effect is achieved.
Description
Technical field
The present invention relates to the technical field of electronic cigarette, more particularly to a kind of with the electronic cigarette for taking good care of function of human body effect
Atomized liquid.
Background technology
Medicated cigarette is liked as a kind of preference by many people, but tar, carbon monoxide (CO) in medicated cigarette are right
The health of human body is harmful, containing 10 kinds of compositions of number is especially carcinogen in tar, at present abroad with state's internal affairs
Mansion progressively regulation forbid smoking cigarettes (Medicated cigarette) in public places, but for one has the smoker of smoking history,
Ask and accomplish no longer to have cigarette smoking, be a very difficult thing, then commercially occur in that the succedaneum of many medicated cigarettes, such as：Guard against
Cigarette buccal tablet, electronic cigarette, found in recent years that electronic cigarette was most commonly seen, and this electronic cigarette is atomized by cigarette bullet, is entered
And smog is produced, but the single function of existing tobacco juice for electronic smoke, it is intended only as simple substitute of tobacco, it is impossible to human body
Play effect that further health care is taken good care of.
The content of the invention
The purpose of the present invention is to propose to it is a kind of with the electronic cigarette atomizing liquid for taking good care of function of human body effect, craving for tobacco can be met
Be conducive to again it is healthy, with taking good care of function of human body effect.
To reach above-mentioned purpose, the present invention propose it is a kind of with the electronic cigarette atomizing liquid for taking good care of function of human body effect, its
It is formulated by weight percentage by following composition：
Natural nicotine 0.05%～2.6%, pure tobacco oil 3%～18%, taurine 0.1%～0.5%, aspartic acid
0.05%～0.1%, isoleucine 0.03%～0.08%, hawthorn fruit tincture 0.4%～5%, Folium Artemisiae Argyi extract 0.5%～5%,
USP levels (USP standard) glycerol 26%～50%, balance of food grade propylene glycol；
The preparation method with the electronic cigarette atomizing liquid for taking good care of function of human body effect is comprised the following steps:
(a) will by formula proportion weighed pure tobacco oil, Folium Artemisiae Argyi extract, taurine, aspartic acid, isoleucine,
Hawthorn fruit tincture is added in deionized water, is heated to 50 DEG C～65 DEG C and is sufficiently stirred for being completely dissolved；
B solution in step (a) is added load weighted food grade propylene glycol by (), be sufficiently stirred for, be again heated to 50 DEG C～
70℃；
C () adds natural nicotine, USP level glycerol after the solution in step (b) is cooled to into 15～30 DEG C, be sufficiently stirred for
It is even；
D () will cool down after the solution fill in step (c) at a temperature of -5 DEG C～0 DEG C, that is, obtain it is described have take good care of people
The electronic cigarette atomizing liquid of body function effect.
Further, above-mentioned with taking good care of in the electronic cigarette atomizing liquid of function of human body effect, the purity of natural nicotine >=
99%.
Further, it is described with taking good care of human body machine above-mentioned with taking good care of in the electronic cigarette atomizing liquid of function of human body effect
The weight ratio of each composition of electronic cigarette atomizing liquid of energy effect is preferably：
Natural nicotine 2.6%, pure tobacco oil 18%, taurine 0.5%, aspartic acid 0.1%, isoleucine
0.08%th, hawthorn fruit tincture 5%, Folium Artemisiae Argyi extract 5%, USP levels glycerol 50%, balance of food grade propylene glycol.
Further, it is described with taking good care of human body machine above-mentioned with taking good care of in the electronic cigarette atomizing liquid of function of human body effect
The weight ratio of each composition of electronic cigarette atomizing liquid of energy effect is preferably：
Natural nicotine 2%, pure tobacco oil 10%, taurine 0.3%, aspartic acid 0.08%, isoleucine 0.05%,
Hawthorn fruit tincture 3%, Folium Artemisiae Argyi extract 3%, USP levels glycerol 35%, balance of food grade propylene glycol.
Further, above-mentioned with taking good care of in the electronic cigarette atomizing liquid of function of human body effect, the hawthorn fruit tincture is by Rosaceae
The fruit of may Fructus Crataegi (Crataegus Pinuatifida) is extracted with ethanol and obtained.
Further, above-mentioned with taking good care of in the electronic cigarette atomizing liquid of function of human body effect, the Folium Artemisiae Argyi extract into
Dividing includes：Terpinenol -4 (terpinenol-4), β-caryophyllene (β-caryophyllene), artemisol (artemisia
Alcohol), linalool (linalool), Camphora (camphae), Borneolum Syntheticum (Borneolum Syntheticum bneol), cineole (cineol,
) and phellandrene (phellrene), Cadinene (cadinene), thujanol (thujyl alcohol) eucalyptol.
Further, above-mentioned with taking good care of in the electronic cigarette atomizing liquid of function of human body effect, the Folium Artemisiae Argyi extract by with
Lower extracting process is made：
The Folium Artemisiae Argyi for taking natural drying is some, is crushed with pulverizer, loads postcritical extraction equipment；
Open water-bath so that the extraction equipment reaches 35 DEG C, and is passed through CO2, the air displacement in system is clean；
Compressor is opened, pressure in extractor is adjusted and is reached 16MPa, and adjust extractor outlet valve so that CO2Flow reaches
To 20kg/h；
Maintenance system opens separator in this state 80min, takes out extract, weighs；
To be extracted to finish, close compressor, steel cylinder are vented CO2, take out Folium Artemisiae Argyi volatile oil；
The Folium Artemisiae Argyi volatile oil of extraction is added in the dehydrated alcohol of doubling dose, is stood overnight after stirring, vacuum filtration, removed
The wax component of precipitation, by filtrate at 30 DEG C decompression recycling ethanol, obtain the Folium Artemisiae Argyi extract.
There is the present invention electronic cigarette atomizing liquid for taking good care of function of human body effect to use taurine, aspartic acid and Chinese mugwort
The material compositions such as leaf extract, so as to reduce content of the nicotine in electronic atomized liquid, while being conducive to healthy, have
Take good care of function of human body effect.
Wherein, taurine (Taurine) is also known as alpha-amido ethyl sulfonic acid, earliest by separating in Calculus Boviss, therefore gains the name.Sterling
For colourless or white ramp-like crystal, odorless, stable chemical nature is dissolved in the organic solvents such as ether, is a kind of non-protein of sulfur-bearing
Aminoacid, in vivo with free state presence, is not involved in the biosynthesiss of vivo protein.
The physiological function of taurine：Nerve conduction and visual function can be improved；Cardiovascular diseasess are prevented, taurine is in cyclic system
Platelet aggregation, reduction blood fat can be suppressed in system to keep human normal blood pressure and prevent arteriosclerosis；Affect the absorption liver of lipid
The effect of dirty middle taurine is to combine to form cholyltaurine with bile acid, and absorption of the taurocholic acid to lipid in digestive tract is required
's.Improve endocrinosity, strengthen human immunity, taurine can promote pituitary hormone secretion, pancreatic function be activated, so as to improve
The state of organism endocrine system, to organism metabolism with beneficial regulation；Grind with the zoopery of brain development relation in taurine
Study carefully middle discovery, taurine can promote the learning and m emaory of rat.The appropriate taurine of supplement not only can improve study note
Recall speed, but also the accuracy of learning and memory can be improved, and the defying age to nervous system also has certain effect.
Aspartic acid is a kind of a-amino acid, and the L- isomeric compounds of aspartic acid are one of 20 kinds of albumen amino acids, i.e. egg
The structure unit of white matter.Its codon is GAU and GAC.It is all acidic amino acid with glutamic acid.Aspartic acid generally existing
In biosynthesiss effect.It is biological aminoacid and purine, the pyrimidine such as lysine, threonine, isoleucine, methionine in vivo
The synthesis precursor of base.It can convey electrolyte as the carrier Cardiomyocytes of K+, Mg2+ ion, so as to improve myocardial contraction work(
Can, while reducing oxygen consumption, in coronary artery circulation obstacle anoxia, there is protective effect to cardiac muscle.It participates in ornithine cycle,
Promote oxygen and carbon dioxide to generate carbamide, reduce the amount of nitrogen and carbon dioxide in blood, strengthen liver function, allaying tiredness.
The effect of isoleucine include with L-Valine together with cooperation repair muscle, control blood glucose, and carry to bodily tissue
Energizing quantity.It also improves the yield of growth hormone, and helps the interior fat that burns, these fat due in body interior, only
By go on a diet and exercise be difficult to they produce useful effect.Because it is easily converted to glucose, therefore isoleucine has
Help adjust blood sugar level.The people that isoleucine lacks occurs similar hypoglycemic symptom, such as has a headache, dizzy, fatigue, suppression
It is strongly fragrant, mental disorder, and irritability etc..
Folium Artemisiae Argyi extract has multi-efficiency：
1st, antifungic action
Folium Artemisiae Argyi is in vitro to anthrax bacillus, Alpha-hemolytic streptococcus, b- Streptococcus hemolyticuss, diphtheria corynebacterium, bacillus pseudodiphthericus, Chinese mugwort
10 kinds of grams such as leaf lung diplococcoid, staphylococcus aureuses, Staphylococcus citreus, staphylococcus aureus, bacillus subtilis
Positive aerophil all has antibacterial action.
2nd, antiasthmatic effect
Terpinenol -4240-300mg/kg the gavages in Oleum Folium Artemisiae Argyi separate or spray delivery, α-terpinenol 80-
120mg/kg gavages, the Experimental Asthma In Guinea-pigs that antihistamine and acetylcholine can be caused, the trans carveol of another two-component
(tcmlibanscarveol) antiasthmatic effect has been displayed that with β-caryophyllene (β-caryophyllene).1% α-terpinenol is inhaled
Enter, the Cavia porcelluss asthma caused to histamine has inhibitory action, and can resist egg albumen sensitization, attack the Guinea pig lung mechanical work for causing
The change of energy, Folium Artemisiae Argyi leaf preserved material has diastole to act on guinea pig bronchial.
3rd, choleretic effect
Take Oleum Folium Artemisiae Argyi capsule, with 2% leaf temperature suspension is made into (per 1ml μ l containing Oleum Folium Artemisiae Argyi 75).Rat 0.8ml/100g and
0.3ml/100g duodenum drug administration by injection, respectively one group and two groups of Oleum Folium Artemisiae Argyi.Positive controls with dehydrocholic acid (dhc),
Every 0.25g, is made into 20% suspension, 0.3ml/100g, 12 fat enteral administrations.Carbon tetrachloride poisoning group：Use carbon tetrachloride
1ml/kg gavages 1 time, poisoning makees cholagogic experiment in 24 hours, with Oleum Folium Artemisiae Argyi 0.3ml/100g duodenal administrations.Matched group uses 2%
Tween 0.3ml/100g duodenal administrations.3 groups of white mice point, Folium Artemisiae Argyi line of oils, 0.2ml/10g duodenal administrations.Dehydrogenation gallbladder
Sour group, 5% dehydrocholic acid 0.2ml/10g duodenal administrations.Physiological saline group, 0.2ml/10g duodenal administrations.Experiment knot
Really：Folium Artemisiae Argyi oil suspension 0.8ml/100g makes normal rat bile flow increase by 91.5%, has pole significance with comparing before administration
Difference；0.3ml/100g groups make normal rat bile flow most increase by 89%, have pole significant difference with comparing before medicine；Dehydrocholic acid
Group makes rat bile flow increase by 83.2%；Carbon tetrachloride poisoning group rat bile flow is also significantly increased, with normal rat
Than choleretic effect weakens, and holds time short；2% tween has no significant effect to bile flow.Oleum Folium Artemisiae Argyi also has significantly to mice
Choleretic effect so as to which bile flow increases by 26%.
4th, platelet aggregation is suppressed
Cupreol and 5,7- dihydroxy -6 in Folium Artemisiae Argyi, 3,4,-trimethoxy flavone, they have aobvious to suppressing platelet aggregation
Works is used.The two kinds of compositions extracted from Folium Artemisiae Argyi, cupreol and 5,7- dihydroxy -6,3,4- trimethoxy flavones are to blood
The extremely significant inhibitory action of platelet populated with.However, both effective ingredient are compared, cupreol act on 0.7,
The latter (p is extremely markedly superior to during 1.35mg/ml dosage<0.001).
To sum up, the present invention has and takes good care of electronic cigarette atomizing liquid of function of human body effect and preparation method thereof by using cattle sulphur
The material compositions such as acid, aspartic acid and Folium Artemisiae Argyi extract, reduce nicotine to harm, while being conducive to body to be good for
Health, with taking good care of function of human body effect.
Specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described：
Embodiment 1
Weigh by weight percentage and prepare each composition that the present invention has the electronic cigarette atomizing liquid for taking good care of function of human body effect
Raw material, each composition raw materials by weight is：Natural nicotine (purity >=99%) 2.6%, pure tobacco oil 18%, cattle sulphur
Acid 0.5%, aspartic acid 0.1%, isoleucine 0.08%, hawthorn fruit tincture 5%, Folium Artemisiae Argyi extract 5%, USP levels glycerol 50%,
Balance of food grade propylene glycol；During preparation,
(a) will by formula proportion weighed pure tobacco oil, Folium Artemisiae Argyi extract, taurine, aspartic acid, isoleucine,
Hawthorn fruit tincture is added in deionized water, is heated to 65 DEG C and is sufficiently stirred for being completely dissolved；
B solution in step (a) is added load weighted food grade propylene glycol by (), be sufficiently stirred for, and is again heated to 70 DEG C；
C () adds natural nicotine, USP level glycerol after the solution in step (b) is cooled to into 30 DEG C, stir；
D () will cool down after the solution fill in step (c) at a temperature of 0 DEG C, that is, obtain it is described have take good care of function of human body
The electronic cigarette atomizing liquid of effect.
Embodiment 2
Weigh by weight percentage and prepare each composition that the present invention has the electronic cigarette atomizing liquid for taking good care of function of human body effect
Raw material, each composition raw materials by weight is：Natural nicotine (purity >=99%) 2%, pure tobacco oil 10%, taurine
0.3%th, aspartic acid 0.08%, isoleucine 0.05%, hawthorn fruit tincture 3%, Folium Artemisiae Argyi extract 3%, USP levels glycerol 35%,
Balance of food grade propylene glycol；During preparation,
(a) will by formula proportion weighed pure tobacco oil, Folium Artemisiae Argyi extract, taurine, aspartic acid, isoleucine,
Hawthorn fruit tincture is added in deionized water, is heated to 55 DEG C and is sufficiently stirred for being completely dissolved；
B solution in step (a) is added load weighted food grade propylene glycol by (), be sufficiently stirred for, and is again heated to 60 DEG C；
C () adds natural nicotine, USP level glycerol after the solution in step (b) is cooled to into 20 DEG C, stir；
D () will cool down after the solution fill in step (c) at a temperature of -2 DEG C, that is, obtain it is described have take good care of function of human body
The electronic cigarette atomizing liquid of effect.
Embodiment 3
Weigh by weight percentage and prepare each composition that the present invention has the electronic cigarette atomizing liquid for taking good care of function of human body effect
Raw material, each composition raw materials by weight is：
Natural nicotine (purity >=99%) 0.05%, pure tobacco oil 3%, taurine 0.1%, aspartic acid 0.05%,
Isoleucine 0.03%, hawthorn fruit tincture 0.4%, Folium Artemisiae Argyi extract 0.5%, USP levels glycerol 26%, balance of food grade propylene glycol；
During preparation,
(a) will by formula proportion weighed pure tobacco oil, Folium Artemisiae Argyi extract, taurine, aspartic acid, isoleucine,
Hawthorn fruit tincture is added in deionized water, is heated to 50 DEG C and is sufficiently stirred for being completely dissolved；
B solution in step (a) is added load weighted food grade propylene glycol by (), be sufficiently stirred for, and is again heated to 50 DEG C；
C () adds natural nicotine, USP level glycerol after the solution in step (b) is cooled to into 15 DEG C, stir；
D () will cool down after the solution fill in step (c) at a temperature of -5 DEG C, that is, obtain it is described have take good care of function of human body
The electronic cigarette atomizing liquid of effect.
Here description of the invention and application are illustrative, are not wishing to limit the scope of the invention to above-described embodiment
In.The deformation and change of embodiments disclosed herein is possible, real for those skilled in the art
The replacement and equivalent various parts for applying example is known.It should be appreciated by the person skilled in the art that without departing from the present invention
Spirit or essential characteristics in the case of, the present invention can in other forms, structure, arrangement, ratio, and with other components,
Material and part are realizing.In the case of without departing from scope and spirit of the present invention, embodiments disclosed herein can be entered
Other deformations of row and change.
Claims (7)
1. it is a kind of with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that it is by following composition by weight hundred
Ratio is divided to be formulated：
Natural nicotine 0.05%～2.6%, pure tobacco oil 3%～18%, taurine 0.1%～0.5%, aspartic acid
0.05%～0.1%, isoleucine 0.03%～0.08%, hawthorn fruit tincture 0.4%～5%, Folium Artemisiae Argyi extract 0.5%～5%,
USP levels glycerol 26%～50%, balance of food grade propylene glycol；
The preparation method with the electronic cigarette atomizing liquid for taking good care of function of human body effect is comprised the following steps:
A () will weigh pure tobacco oil, Folium Artemisiae Argyi extract, taurine, aspartic acid, isoleucine, Fructus Crataegi by formula proportion
Tincture is added in deionized water, is heated to 50 DEG C～65 DEG C and is sufficiently stirred for being completely dissolved；
B solution in step (a) is added load weighted food grade propylene glycol by (), be sufficiently stirred for, and is again heated to 50 DEG C～70 DEG C；
C () adds natural nicotine, USP level glycerol after the solution in step (b) is cooled to into 15～30 DEG C, stir；
D () will cool down after the solution fill in step (c) at a temperature of -5 DEG C～0 DEG C, that is, obtain it is described have take good care of human body machine
The electronic cigarette atomizing liquid of energy effect.
2. it is according to claim 1 with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that the day
Purity >=99% of right nicotine.
3. it is according to claim 1 with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that the tool
The weight ratio for having each composition of electronic cigarette atomizing liquid for taking good care of function of human body effect is：
Natural nicotine 2.6%, pure tobacco oil 18%, taurine 0.5%, aspartic acid 0.1%, isoleucine 0.08%, mountain
Short, bristly hair or beard tincture 5%, Folium Artemisiae Argyi extract 5%, USP levels glycerol 50%, balance of food grade propylene glycol.
4. it is according to claim 1 with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that the tool
The weight ratio for having each composition of electronic cigarette atomizing liquid for taking good care of function of human body effect is：
Natural nicotine 2%, pure tobacco oil 10%, taurine 0.3%, aspartic acid 0.08%, isoleucine 0.05%, Fructus Crataegi
Tincture 3%, Folium Artemisiae Argyi extract 3%, USP levels glycerol 35%, balance of food grade propylene glycol.
5. it is according to claim 1 with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that the mountain
Short, bristly hair or beard tincture is extracted by the fruit of Rosaceae Crataegus plant Fructus Crataegi with ethanol and obtained.
6. it is according to claim 1 with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that the Chinese mugwort
The composition of leaf extract includes：Terpinenol -4, β-caryophyllene, artemisol, linalool, Camphora, Borneolum Syntheticum, cineole and Herba Oenanthes Javanicae
Alkene, Cadinene, thujanol.
7. it is according to claim 1 with the electronic cigarette atomizing liquid for taking good care of function of human body effect, it is characterised in that the Chinese mugwort
Leaf extract is made up of following extracting process：
The Folium Artemisiae Argyi for taking natural drying is some, is crushed with pulverizer, loads postcritical extraction equipment；
Open water-bath so that the extraction equipment reaches 35 DEG C, and is passed through CO2, the air displacement in system is clean；
Compressor is opened, pressure in extractor is adjusted and is reached 16MPa, and adjust extractor outlet valve so that CO2Flow reaches
20kg/h；
Maintenance system opens separator in this state 80min, takes out extract, weighs；
To be extracted to finish, close compressor, steel cylinder are vented CO2, take out Folium Artemisiae Argyi volatile oil；
The Folium Artemisiae Argyi volatile oil of extraction is added in the dehydrated alcohol of doubling dose, is stood overnight after stirring, vacuum filtration, remove precipitation
Wax component, by filtrate at 30 DEG C decompression recycling ethanol, obtain the Folium Artemisiae Argyi extract.
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| CN105412192B (en) * | 2016-01-15 | 2020-11-27 | 皖南医学院 | Folium artemisiae argyi mite removing cream and extraction method of folium artemisiae argyi volatile oil |
| CN106820267A (en) * | 2016-12-28 | 2017-06-13 | 深圳瀚星翔科技有限公司 | A kind of electronic cigarette tobacco tar and preparation method thereof |
| CN108142982A (en) * | 2018-02-02 | 2018-06-12 | 新智能生活馆（深圳）有限公司 | A kind of electronic atomized energy bullet |
| CN109549246A (en) * | 2019-01-18 | 2019-04-02 | 薪火高科(深圳)有限公司 | A kind of tobacco juice for electronic smoke and preparation method thereof of adjustable function of human body |
| CN113854620A (en) * | 2021-09-02 | 2021-12-31 | 深圳市艾普生物科技有限公司 | Electronic cigarette liquid additive and preparation method and application thereof |
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| CN101933653B (en) * | 2010-08-09 | 2012-10-10 | 深圳市如烟生物科技有限公司 | Officinal health-care solid electronic aerosolization liquid and preparation method thereof |
| ITMI20112290A1 (en) * | 2011-12-16 | 2013-06-17 | Dks Aromatic Srl | COMPOSITION FOR ELECTRONIC CIGARETTES |
| CN103919274B (en) * | 2013-01-16 | 2016-08-10 | 深圳瀚星翔科技有限公司 | A kind of electronic cigarette atomizing liquid |
| CN104473323A (en) * | 2014-12-03 | 2015-04-01 | 河南中烟工业有限责任公司 | Electronic cigarette atomizing agent |
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