CN109998151A - Medium chain triglyceride is improving and/or is reducing the application in respiratory tract - Google Patents

Abstract

It is stimulation caused by application tobacco product that the present invention, which provides medium chain triglyceride improving and/or reducing the application in respiratory tract, the respiratory tract, it is preferred that the respiratory tract is the respiratory tract that propylene glycol generates in tobacco product.

Description

Medium chain triglyceride is improving and/or is reducing the application in respiratory tract

Technical field

The invention belongs to tobacco product fields, and in particular to medium chain triglyceride is improving and/or reducing tobacco product pair Application in respiratory tract, in particular to medium chain triglyceride are improving and/or are reducing propylene glycol in respiratory tract Using.

Background technique

With the improvement of living standards, people increase the consumption of cigarette and accelerate, and count according to World Health Organization (WHO), the whole world Smoker's number has had reached nearly 1,000,000,000 people, the various disease deaths that the whole world in 2016 has more than 700 ten thousand people to cause by smoking, In, the most country of death toll is China, about 1,770,000 people.The flue gas generated when smoking enters from mouth, by larynx Throat, trachea-bronchial epithelial cell, into blood, smoking endangers respiratory tract maximum, it is easy to cause laryngitis, tracheitis, pulmonary emphysema Equal coughs, also increase risk of cancer, the carcinogenic substance inventory edit reference that WHO international cancer research institution in 2017 announces In, it smokes as a kind of carcinogenic substance.

As described above, the smog of cigarette flows primarily through respiratory tract, respiratory system is endangered larger.Respiratory mucosa epithelium energy Poisonous substance is enough absorbed, while with the cilium that can be trembleed on the mucous membrane of trachea and bronchus, protecting respiratory tract simultaneously under normal circumstances It is set to keep cleaning.Nicotine in cigarette is the stronger chemical substance of toxicity, it can stimulate mucous membrane and by mucosa absorption, make mind Adverse reaction occurs through system, and undesirable consequence is caused to blood vessel by nerve, vasopasm, vasopermeability is caused to increase Add, promote arterial pressure raising, increased heart rate, cardiac arrhythmia etc.；Carbon monoxide in cigarette is to cause ischemic cardiovascular disease The key factor of disease；Also containing gases such as some arsenic, the toxin of mould generation and ammonia in smoke from cigarette.In addition, the cigarette in smog For dirt particle 50,000 times about more than the particle in normal air, a large amount of toxin is also contained in the inside, loses the cilium of respiratory tract and mucus Go its due protective effect.As it can be seen that smoke from cigarette has very strong irritation to respiratory tract, and mucous membrane is damaged.

With popularizing for harmfulness of smoking knowledge, electronic cigarette is increasingly becoming the healthy substitute of cigarette.Existing electronic cigarette is big Part produces steam using liquid atomiser, battery, heating coil and liquid memory, and liquid heats in atomizer, and About 65-120 DEG C vaporization, smoker is by lower button or makes the i.e. usable cigarette of the movement of suction.

Common ingredient includes nicotine, cannboid, solvent, stabilizer, plasticizer, fragrance, preservative etc. in electronic cigarette, Although harm of the electronic cigarette compared with conventional cigarette reduces, there are still the stimulation to throat, part population still will appear larynx Phenomena such as throat discomfort, more phlegm, allergy, in addition, the choosing of the structure and material of the different designs of electronic cigarette utensil, especially atomizer Excitement is generated with user may also be will lead to.

Medium chain triglyceride (MCT) is a kind of saturated fatty acid, and in food and additive in cigarette industry, MCT be can be used as The solvent and carrier of edible essence and pigment are alternatively arranged as after performing the operation, the special food of infection and skin burn patient.Currently, Medium chain triglyceride has been applied in smoking article, such as electronic cigarette, usually as solvent or improves mouthfeel.

Patent WO2013116558A1 discloses a kind of electronic article for smoking, including being dispersed in fibre element At least one additive includes the MCT for improving mouthfeel in the additive.

Patent EP2578093B1 discloses a kind of cigarette filter, includes fragrance in the filter tip, the fragrance Solvent is MCT.

Patent CN105925376A discloses essence and its application of a kind of quick-fried pearl of cigarette, including 2,3- dimethyl pyrazine, Clove bud oil, lactic acid, ethylmaltol, ethylcyclopentenolone, vanillic aldehyde, 2,6- syringol and medium chain triglyceride three 15-20 μ L essence is wrapped in capsule by ester in a manner of injecting flavoring, is then placed in the middle part of the filter tip an of cigarette.

Patent CN201710288603.X discloses a kind of cigarette quick-fried pearl fructus lycii essence and its application in cigarette, Chinese holly Qi essence is made of wolfberry fruit extract, isoamyl acetate, benzyl carbinol, ethyl benzoate, adjacent bitter orange oil, Glycerin, mixed triester with caprylic acid capric acid, should After the quick-fried pearl merging cigarette filter of essence preparation, the irritation of cigarette, improvement and abundant cigarette flavor can be weakened.

Present inventors have surprisingly found that can be improved using medium chain triglyceride and/or reduce electronic cigarette liquid to respiratory tract Stimulation particularly can be improved using medium chain triglyceride and/or reduce in electronic cigarette liquid common auxiliary material propylene glycol to exhaling The malaise symptoms such as cough, allergy, the more phlegm being likely to occur when inhaling the stimulation in road, and then can alleviate using electronic cigarette.

Summary of the invention

One object of the present invention provides medium chain triglyceride answering in the stimulation for improving and/or reducing respiratory tract With.

Another object of the present invention, which provides medium chain triglyceride, improves and/or reduces the product of respiratory tract in preparation In application.

Another object of the present invention provides a kind of composition comprising medium chain triglyceride, and the composition is improving And/or reduction improves the application in the stimulation of respiratory tract.

Another object of the present invention provides a kind of electronic cigarette liquid comprising medium chain triglyceride and changes improving and/or reduce Application in the stimulation of kind respiratory tract.

Specifically, in a first aspect, the present invention provides medium chain triglycerides to improve and/or reduce answering for respiratory tract With, it is preferred that the respiratory tract is respiratory tract caused by application tobacco product, it is furthermore preferred that the respiratory tract pierces Swash for respiratory tract caused by application electronic cigarette.

Second aspect, the present invention provides medium chain triglycerides to improve and/or reduce the product of respiratory tract in preparation In application, it is preferred that the respiratory tract be application tobacco product caused by respiratory tract, it is furthermore preferred that described exhale Road stimulation is inhaled for respiratory tract caused by application electronic cigarette.

In a specific embodiment of the present invention, contain middle chain in the product of the improvement and/or reduction respiratory tract Triglycerides, it is preferred that the improvement and/or to reduce in the product of respiratory tract containing weight percent be 1-99%'s Medium chain triglyceride, it is furthermore preferred that the middle chain containing 20-90% in the product of the improvement and/or reduction respiratory tract Triglycerides, particularly preferred, the middle chain containing 30-90% is sweet in the product of the improvement and/or reduction respiratory tract Oily three esters, for example, the improvement and/or reduce in the product of respiratory tract containing 30%, 40%, 50%, 60%, 70%, 80%, 90% medium chain triglyceride.

In a specific embodiment of the present invention, the medium chain triglyceride both can be used as preparation and improve and/or reduce The addition auxiliary material of the product of respiratory tract can also be removed before the product that improvement and/or reduction respiratory tract is prepared It goes, is only stayed in the product with residual component.

Respiratory tract of the present invention can be in stimulation or the tobacco of the generation of the toxic component in tobacco Add the stimulation that auxiliary material generates.In embodiments of the present invention, the respiratory tract is nicotine, molten in electronic cigarette Agent, preservative, stabilizer, fragrance etc. add the stimulation that auxiliary material generates, it is preferred that the respiratory tract is adding in electronic cigarette The respiratory tract for adding auxiliary material propylene glycol to generate.

Solvent of the present invention is selected from ethyl alcohol, diethylene glycol (DEG), triethylene glycol, glycerol, propene carbonate, propylene glycol, butanediol Or the combination of one or more of polyethylene glycol.

Preservative of the present invention is selected from ascorbic acid, Chlorphenesin, sodium benzoate, methylparaben, nipalgin second The combination of one or more of ester, propylben or nipalgin mixing rouge sodium.

Stabilizer of the present invention is selected from pectin, konjac glucomannan, xanthan gum, modified modified starch, sodium alginate or casein The combination of one or more of sour sodium.

Fragrance of the present invention is selected from the group of one or more of peppermint oil, anethole, essence, lemon oil It closes.

Propylene glycol of the present invention includes 1,2- propylene glycol and/or 1,3- propylene glycol.

The carbon atom number that the carbochain of medium chain triglyceride of the present invention contains is 6-12, it is preferred that the middle chain The carbon atom number that the carbochain of triglycerides contains is 7-11, it is furthermore preferred that the carbochain of the medium chain triglyceride contained Carbon atom number is 8-10.

Preferably, it is pungent to be selected from saturation Trivent OCG, saturation Triglyceride DDD or saturation for the medium chain triglyceride The combination of one or more of acid-capric acid mixing triglycerides.It is mentioned in the specific embodiment of the present invention A kind of saturation Trivent OCG has been supplied to prepare the application in improvement and/or the electronic cigarette liquid for reducing respiratory tract.

Provide in another embodiment of the invention a kind of saturation Triglyceride DDD preparation improve and/ Or the application in the electronic cigarette liquid of reduction respiratory tract.

Improvement and/or reduction respiratory tract of the present invention includes improving and/or reducing upper respiratory tract stimulation, lower breathing Road stimulation and the disease as caused by upper and lower respiratory tract or symptom.

Upper respiratory tract stimulation of the present invention and the disease caused by upper respiratory tract stimulation include but is not limited to pharyngitis, larynx Inflammation, rhinitis, nasosinusitis, the infection of the upper respiratory tract.

Lower respiratory tract stimulation of the present invention and the disease caused by lower respiratory tract stimulation include but is not limited to cough, tracheae Inflammation chronic bronchitis, acute bronchitis, lower respiratory tract infection, is coughed up phlegm, asthma, airway obstruction, pneumonia, pulmonary emphysema, lung knot Core, atelectasis, hypertension, lung cancer, pneumothorax.

Symptom caused by respiratory tract of the present invention be selected from nasal obstruction, runny nose, sneeze, cough, more phlegm, pharyngeal discomfort, Congestion of throat, pharyngalgia, fever, dysphoria, headache, general malaise, out of strength, antiadoncus, lower jaw and enlarged lymph nodes of neck A combination of one or more.

In a specific embodiment of the invention, symptom caused by the respiratory tract is third in application tobacco product The respiratory tract that glycol generates, including cough, more phlegm and pharyngalgia.

The third aspect, the present invention provide a kind of composition, contain medium chain triglyceride and food in the composition Or acceptable addition auxiliary material, the composition can be used for improving and/or reducing respiratory tract on drug.

In a specific embodiment of the present invention, contain medium chain triglyceride in the composition, it is preferred that the group The medium chain triglyceride for being 1-99% containing weight percent in object is closed, it is furthermore preferred that containing 20-90% in the composition Medium chain triglyceride, particularly preferred, containing the medium chain triglyceride of 30-90% in the composition, example is as mentioned In composition containing 30%, 40%, 50%, 60%, 70%, 80%, 90% medium chain triglyceride.

Preferably, the carbon atom number that the carbochain of the medium chain triglyceride contains is 7-11, it is furthermore preferred that in described The carbon atom number that the carbochain of chain triglyceride contains is 8-10.

Preferably, it is pungent to be selected from saturation Trivent OCG, saturation Triglyceride DDD or saturation for the medium chain triglyceride The combination of one or more of acid-capric acid mixing triglycerides.

Acceptable addition auxiliary material is selected from carrier, excipient, diluent, lubrication on food or drug of the present invention It is agent, wetting agent, emulsifier, preservative, antioxidant, buffer, bacteriostatic agent, suspending agent, suspending agent, solubilizer, thickener, steady Determine the combination of one or more of agent, sweetener and fragrance.

The form of composition of the present invention can be solution, suspending agent, pulvis, granule, tablet, capsule, pastille, Gelling agent, emulsion etc..

Fourth aspect, the present invention also provides the compositions to improve and/or reduce the product of respiratory tract in preparation In application.The preparation of the composition is preferably unit dosage forms, and the preparation is subdivided into the active group comprising amount appropriate The unit dose divided.The unit dosage forms can be packaged preparation, and contain the preparation of discrete amount, such as be packaged in small Bottle or the solution in ampoule, tablet, capsule and pulvis.Composition of the present invention can be added in tobacco product or Person uses in preparing tobacco product, and example composition as mentioned can be added to the composition in electronic cigarette liquid or described It can be used for preparing the solvent of tobacco product.In the context of the present invention, give use should be enough object dosage, and with the time Beneficial response is generated in subject.Dosage is by depending on the case where the effect and object of the specific composition used.

The product of improvement and/or reduction respiratory tract of the present invention includes but is not limited to smoking article, food, medicine Product or health care product, it is preferred that the product is tobacco juice, quick-fried pearl, aromatizing agent etc..

Therefore, another aspect of the present invention additionally provides a kind of electronic cigarette liquid, presses quality percentage in the electronic cigarette liquid Than including medium chain triglyceride 1%-99%, it is preferred that the medium chain triglyceride three in the electronic cigarette liquid containing 20-90% Ester, it is particularly preferred, containing the medium chain triglyceride of 30-90% in the electronic cigarette liquid, in example electronic cigarette liquid as mentioned Contain 30%, 40%, 50%, 60%, 70%, 80%, 90% medium chain triglyceride.

In a specific embodiment of the invention, the electronic cigarette liquid further include nicotine, industrial hemp extract it is big One or more of the hemp essential oil that numb element or industrial hemp extract ingredient.

In a specific embodiment of the invention, the electronic cigarette liquid further include other natural plant extracts, solvent, One or more of preservative, stabilizer or fragrance etc. ingredient.

In a specific embodiment of the invention, the cannboid or industry that nicotine, industrial hemp extract in the tobacco juice One or more of the hemp essential oil that hemp is extracted ingredient is 0.01%-10% by weight percentage, it is preferred that described One or more of hemp essential oil that cannboid that nicotine in tobacco juice, industrial hemp extract, industrial hemp extract at Divide is 0.1%-2% by weight percentage.

It in a specific embodiment of the invention, by weight percentage include the hemp of industrial hemp extraction in the tobacco juice Plain 0.01%-10%, it is preferred that the cannboid 0.1%-2% extracted by weight percentage containing industrial hemp in the tobacco juice. Cannboid of the present invention is selected from cannabidiol CBD, cannabidivarin CBDV, cannabigerol CBG, tetrahydrocannabinol THCV Or the combination of one or more of cannabinol CBN, tetrahydrocannabinol THC is free of in the cannboid.

It in a specific embodiment of the invention, by weight percentage include solvent 0.9%-98% in the tobacco juice, it is excellent Choosing, it is particularly preferred containing the solvent of 9-79% in the electronic cigarette liquid, contain 9-69%'s in the electronic cigarette liquid Solvent.

It in a specific embodiment of the invention, by weight percentage include stabilizer 1%-5% in the tobacco juice, preferably , it by weight percentage include stabilizer 2%-4% in the tobacco juice

It in a specific embodiment of the invention, by weight percentage include fragrance 0.1%-5% in the tobacco juice, preferably , it by weight percentage include fragrance 0.1%-1% in the tobacco juice.

It in a specific embodiment of the invention, by weight percentage include preservative 0.1%-3% in the tobacco juice, it is excellent Choosing, include preservative 0.1%-1% in the tobacco juice by weight percentage.

It in a specific embodiment of the invention, by weight percentage include other natural extracts in the tobacco juice 0.1%-30%, it is preferred that by weight percentage include other natural extracts 0.1%-10% in the tobacco juice.

Additionally providing a kind of electronic cigarette liquid in a specific embodiment of the invention is improving and/or is reducing respiratory tract In application.Preferably, the improvement and/or reduction respiratory tract are non-treatment purpose.

Unless otherwise stated, term " acceptable addition auxiliary material on food or drug " is meant that the ingredient is not given birth to Object activity or other bad active impurity, such as the ingredient can be included in disclosed food or drug and give user, but Do not cause significant bad biological effect or generates interaction with the other compositions for including in said preparation in harmful manner.

Unless otherwise stated, term " alleviate and/or reduce " includes inhibiting, delay, mitigating, weaken, limitation, mitigating Or recession disease, illness or state.

Unless otherwise stated, term "comprising" indicates " opening " or " inclusive " term, so that they include enumerating Element, but also allow to include additional, unmentioned element.

Specific embodiment

Below in conjunction with the embodiment of the present invention, technical solution of the present invention is clearly and completely described, it is clear that institute The embodiment of description is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, originally Field those of ordinary skill every other embodiment obtained without creative efforts, belongs to the present invention The range of protection.

The preparation of electronic cigarette liquid of the embodiment 1 containing nicotine

Prescription:

Ingredient	Content (%)
		Nicotine	1.2
MCT	35
		1,2- propylene glycol	55
Purified water	4.3
		Sodium benzoate	0.5
Essence	4

Preparation method:

Each ingredient is measured by formula, nicotine is dissolved in MCT, 1,2-PD and purified water, is added after to be dissolved Sodium benzoate is eventually adding essence, is sufficiently stirred to get electronic cigarette liquid.

The preparation of electronic cigarette liquid of the embodiment 2 containing nicotine

Prescription:

Ingredient	Content (%)
		Nicotine	1.2
MCT	1
		1,2- propylene glycol	78
Purified water	12.8
		Sodium benzoate	3
Essence	4

Preparation method:

Each ingredient is measured by formula, nicotine is dissolved in MCT, 1,2-PD and purified water, is added after to be dissolved Sodium benzoate is eventually adding essence, is sufficiently stirred to get electronic cigarette liquid.

The preparation of electronic cigarette liquid of the embodiment 3 containing cannboid

Cannboid preparation method:

It is 60 mesh coarse powder that industrial hemp floral leaf raw material, which is crushed, at 150 DEG C, toasts 30min；By above-mentioned coarse powder with 11 times 95% ethyl alcohol soaking at room temperature 2h, cold-maceration extract 3 times, merge to obtain extracting solution；65 DEG C of extracting solution are concentrated into alcoholic strength 72%, sheet frame Filtering obtains supernatant；Supernatant crosses HZ18 macroreticular resin, to purify washing 3BV, first with 20% ethanol washing 5BV, then with 80% ethanol elution 6BV merges eluent；Eluent is concentrated, and alcoholic strength 55% is concentrated into, respectively upper secondary chromatographic column, Filler is respectively DM130 and MCI；90% ethyl alcohol of concentrate and acetonitrile are eluted with the eluent that 10:1 is made into, and are washed De- liquid；Eluent is concentrated under reduced pressure, and 55-70 DEG C, -0.10MPa, until stiff paste；50 times of amount water and 5 times are added at 50 DEG C in stiff paste Acetone is measured, filters, is stored at room temperature while hot, room temperature to be restored, it is seen that crystal is precipitated in side wall and bottom, is placed in 4-10 freezer knot It is brilliant；Crystal recycling is filtered to dry, then with the elution of a small amount of purified water until efflux clear, colorless, digs out crystal, be placed in 40-50 DEG C vacuum drying, -0.10MPa, 24-36h, until determination of moisture 2% hereinafter, getting product.

The mass percent that mass percent through CBD in HPLC measurement products obtained therefrom is 60%, CBDV is 15%, CBG Mass percent be 12%, THCV mass percent be 10%.

Prescription:

Ingredient	Content (%)
		Cannboid	9.8
MCT	80
		1,2- propylene glycol	9.2
Sodium benzoate	0.5
		Essence	0.5

Preparation method:

Each ingredient is measured by formula, cannboid is dissolved in MCT and 1,2-PD, benzoic acid is added after to be dissolved Sodium is eventually adding essence, is sufficiently stirred to get electronic cigarette liquid.

The preparation of electronic cigarette liquid of the embodiment 4 containing cannboid

Cannboid preparation method: with embodiment 3.

Prescription:

Ingredient	Content (%)
		Cannboid	1
MCT	99

Preparation method:

Each ingredient is measured by formula, cannboid is dissolved in MCT to get electronic cigarette liquid.

The preparation of electronic cigarette liquid of the embodiment 5 containing hemp essential oil

Hemp essential oil preparation method:

It by hempseed decladding, cleans, air-dried, obtains raw material；Above-mentioned raw material are beaten into powder, 160 DEG C of baking 60min, former material Expect that moisture is lower than 8%；Into the raw material after drying according to mass ratio be added 8 times amount water, impregnate 1h, hyperbaric heating to 160 DEG C, Continue 2.5h, collects water oil mixed steam；The water oil mixed steam condensation of collection, extraction, concentration and removal obtain hemp essential oil.

Prescription:

Ingredient	Content (%)
		Hemp essential oil	10
MCT	30
		1,2- propylene glycol	32.5
Polyethylene glycol 400	22
		Sodium benzoate	0.5
Essence	5

Preparation method:

Each ingredient is measured by formula, hemp essential oil is dissolved in MCT and 1,2-PD, poly- second two is added after to be dissolved Alcohol 400 and sodium benzoate, are eventually adding essence, are sufficiently stirred to get electronic cigarette liquid.

The preparation of quick-fried pearl of the embodiment 6 containing hemp essential oil

Hemp essential oil preparation method: with embodiment 5.

Prescription:

Ingredient	Content (%)
		Hemp essential oil	0.4
MCT	32.5
		1,2- propylene glycol	20.6
Hydroxypropyl methyl cellulose	38
		Water	8.5

Preparation method:

Water, hydroxypropyl methyl cellulose are mixed, heating and melting, obtains shell material glue while stirring；By hemp essential oil, MCT and 1,2-PD mixing, stir evenly acquisition mixed liquor；In dripping equipment, shell material glue is introduced by outer layer, is mixed Liquid is introduced by internal layer, cooling after being formed with one heart, obtains wet ball；Wet ball calcification, oil suction and drying, obtain quick-fried pearl.

The preparation of electronic cigarette liquid of the embodiment 7 without containing MCT

Prescription:

Ingredient	Content (%)
		Nicotine	1.2
Glycerine	35
		1,2- propylene glycol	55
Purified water	4.3
		Sodium benzoate	0.5
Essence	4

Preparation method:

Each ingredient is measured by formula, nicotine is dissolved in glycerine, 1,2-PD and purified water, is added after to be dissolved Enter sodium benzoate, be eventually adding essence, is sufficiently stirred to get electronic cigarette liquid.

Influence experiment of the MCT to user in 8 tobacco juice of embodiment

One, materials and methods:

1.1 study population

For the curative effect for studying medium chain triglyceride, it is included in 50 electronics containing medium chain triglyceride for sucking embodiment 1 The personnel of cigarette are experimental group, according to age-matched 50 of experimental group personnel suck embodiment 7 without containing medium chain triglyceride three The personnel of the electronic cigarette of ester compare.Two groups of crowds of strict control keep identical common mixed diet, living environment and Life exercise habit continues 3 months.The personnel of experimental group and control group are without serious respiratory disease.

1.2 research method

The mode of the personnel of experimental group and control group itself cross-reference is taken to study medium chain triglyceride to improving the third two The influence of respiratory tract caused by alcohol.Means of intervention: what (1) experimental group personnel sucked that embodiment 1 is prepared daily contains The electronic cigarette for being saturated Trivent OCG is primary, inhales an electronic cigarette every time；(2) control group personnel suck embodiment daily The 7 ordinary electronic cigarettes that are prepared are primary, inhale an electronic cigarette every time.Observing the course for the treatment of is surrounding, observation experiment descendant The cough of group, raw phlegm and pharyngalgia symptom.

Two, experimental result

	1 experimental group of embodiment	7 experimental group of embodiment
			Cough	3	8
Raw phlegm	7	14
			Pharyngalgia	2	5

The result shows that sucking the electronic cigarette containing MCT that embodiment 1 is prepared there is cough, raw phlegm and anginosis The number of shape, which is considerably less than, sucks the electronic cigarette without containing MCT that embodiment 7 is prepared, it is seen that MCT can improve electronics The respiratory tract that propylene glycol generates in tobacco juice.

Embodiment 9MCT causes the influence of mouse cough to be tested spray-on process

One, experimental animal:

18-22g ICR mouse 60 is taken, half male and half female is randomly divided into 6 groups, every group 10 by weight.

Two, spraying scheme:

Medical fluid (wt.%)	Blank group	Experimental group 1	Experimental group 2	Experimental group 3	Control group 1	Control group 2
							Nicotine	-	1	1	1	1	1
MCT	-	30	60	90
							1,2- propylene glycol	-	69	38	9	69
Water		-	-	-	30	99

Three, experimental program:

Each group mouse fasting 16 hours, mouse is put into instrument to induce to cough and asthma before testing, and is prepared according to above-mentioned aerosol spraying scheme Tobacco juice takes 6mg tobacco juice heating atomization to spray into instrument to induce to cough and asthma every time, 3 times a day, carries out 5 days altogether, observes and records and first appear The number of days of cough and total degree of coughing in 5min after spraying into every time, wherein the first appears cough for N days and be recorded as N and divide that (the N days still Do not occur cough so and be recorded as N points), average and the average cumulative cough for calculating every group of the number of days for first appearing cough are total Number.

Four, experimental result:

The result shows that can be relieved mouse when the MCT of 30-90% is added in tobacco juice sucks cough caused by smog Cough, in particular, when in tobacco juice be added 90% MCT when alleviate mouse suck cough caused by smog effect it is more excellent, experimental group 1 Illustrate with the comparing result of control group 1 and 2, MCT is more efficient to the alleviation of cough caused by 1,2-PD in tobacco juice.

The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this A little simple variants all belong to the scope of protection of the present invention.

It is further to note that specific technical features described in the above specific embodiments, in not lance In the case where shield, can be combined in any appropriate way, in order to avoid unnecessary repetition, the present invention to it is various can No further explanation will be given for the combination of energy.

Claims (13)

1. medium chain triglyceride is improving and/or is reducing the application in respiratory tract.

2. medium chain triglyceride according to claim 1 is improving and/or is reducing the application in respiratory tract, feature It is, the carbon atom number that the carbochain of the medium chain triglyceride contains is 6-12, it is preferred that the medium chain triglyceride The carbon atom number that carbochain contains is 8-10.

3. medium chain triglyceride according to claim 2 is improving and/or is reducing the application in respiratory tract, feature It is, the medium chain triglyceride is selected from saturation Trivent OCG, saturation Triglyceride DDD or saturation caprylic-capric acid mixing One or more of triglycerides combination.

4. medium chain triglyceride according to claim 1 is improving and/or is reducing the application in respiratory tract, feature It is, the respiratory tract is stimulation caused by application tobacco product, it is preferred that the respiratory tract is application electronic cigarette Caused stimulation.

5. medium chain triglyceride according to claim 4 is improving and/or is reducing the application in respiratory tract, feature It is, the respiratory tract is the respiratory tract that propylene glycol generates in tobacco product.

6. application of the medium chain triglyceride according to claim 5 in the product that preparation improves respiratory tract, special Sign is that the respiratory tract that propylene glycol generates in the tobacco product is that the upper respiratory tract stimulates, lower respiratory tract stimulates and by upper Disease caused by lower respiratory tract stimulates or symptom.

7. medium chain triglyceride improves and/or reduces the application in the product of respiratory tract in preparation.

8. medium chain triglyceride according to claim 7 improves in preparation and/or reduces in the product of respiratory tract Using, which is characterized in that the product is selected from tobacco product, food, drug, health care product.

9. medium chain triglyceride according to claim 8 improves in preparation and/or reduces in the product of respiratory tract Using, which is characterized in that the product is selected from tobacco juice, quick-fried pearl or aromatizing agent.

10. medium chain triglyceride according to claim 8 improves in preparation and/or reduces in the product of respiratory tract Using, which is characterized in that it by mass percentage include medium chain triglyceride 1%-99% in the product, it is preferred that institute Particularly preferred containing the medium chain triglyceride of 20-90% in the product stated, in the product containing 30-90% middle chain Triglycerides.

11. medium chain triglyceride according to claim 8 improves in preparation and/or reduces in the product of respiratory tract Using, which is characterized in that further include in the product nicotine, industrial hemp extract cannboid, industrial hemp extracts The combination of one or more of hemp essential oil, other natural plant extracts, solvent, preservative, stabilizer or fragrance.

12. medium chain triglyceride according to claim 11 improves in preparation and/or reduces in the product of respiratory tract Application, which is characterized in that in the product by weight percentage include solvent 0.9%-98%, it is preferred that the electronics It is particularly preferred containing the solvent of 9-79% in tobacco juice, the solvent of 9-69% is contained in the electronic cigarette liquid.

13. medium chain triglyceride according to claim 12 improves in preparation and/or reduces in the product of respiratory tract Application, which is characterized in that the solvent be propylene glycol.