CN107129869A - Smooth breathing essential oil and preparation method and application - Google Patents
Smooth breathing essential oil and preparation method and application Download PDFInfo
- Publication number
- CN107129869A CN107129869A CN201710249758.2A CN201710249758A CN107129869A CN 107129869 A CN107129869 A CN 107129869A CN 201710249758 A CN201710249758 A CN 201710249758A CN 107129869 A CN107129869 A CN 107129869A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- essential oil
- preparation
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000341 volatile oil Substances 0.000 title claims abstract description 84
- 238000002360 preparation method Methods 0.000 title claims description 24
- 230000029058 respiratory gaseous exchange Effects 0.000 title abstract description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 45
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims abstract description 24
- NDVASEGYNIMXJL-UHFFFAOYSA-N sabinene Chemical compound C=C1CCC2(C(C)C)C1C2 NDVASEGYNIMXJL-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 19
- IGODOXYLBBXFDW-UHFFFAOYSA-N alpha-Terpinyl acetate Chemical compound CC(=O)OC(C)(C)C1CCC(C)=CC1 IGODOXYLBBXFDW-UHFFFAOYSA-N 0.000 claims abstract description 18
- 150000002729 menthone derivatives Chemical class 0.000 claims abstract description 13
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 12
- NDVASEGYNIMXJL-NXEZZACHSA-N (+)-sabinene Natural products C=C1CC[C@@]2(C(C)C)[C@@H]1C2 NDVASEGYNIMXJL-NXEZZACHSA-N 0.000 claims abstract description 12
- NFLGAXVYCFJBMK-IUCAKERBSA-N (-)-isomenthone Chemical compound CC(C)[C@@H]1CC[C@H](C)CC1=O NFLGAXVYCFJBMK-IUCAKERBSA-N 0.000 claims abstract description 12
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims abstract description 12
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims abstract description 12
- WWRCMNKATXZARA-UHFFFAOYSA-N 1-Isopropyl-2-methylbenzene Chemical compound CC(C)C1=CC=CC=C1C WWRCMNKATXZARA-UHFFFAOYSA-N 0.000 claims abstract description 12
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 12
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 claims abstract description 12
- KQAZVFVOEIRWHN-UHFFFAOYSA-N alpha-thujene Natural products CC1=CCC2(C(C)C)C1C2 KQAZVFVOEIRWHN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930006722 beta-pinene Natural products 0.000 claims abstract description 12
- 150000002148 esters Chemical class 0.000 claims abstract description 12
- NFLGAXVYCFJBMK-UHFFFAOYSA-N isomenthone Natural products CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930007744 linalool Natural products 0.000 claims abstract description 12
- 229940041616 menthol Drugs 0.000 claims abstract description 12
- 229930006696 sabinene Natural products 0.000 claims abstract description 12
- IPZIYGAXCZTOMH-UHFFFAOYSA-N alpha-eudesmol Natural products CC1=CCCC2CCC(CC12)C(C)(C)O IPZIYGAXCZTOMH-UHFFFAOYSA-N 0.000 claims abstract description 11
- WWULHQLTPGKDAM-UHFFFAOYSA-N gamma-eudesmol Natural products CC(C)C1CC(O)C2(C)CCCC(=C2C1)C WWULHQLTPGKDAM-UHFFFAOYSA-N 0.000 claims abstract description 11
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 26
- 239000000047 product Substances 0.000 claims description 25
- 239000000284 extract Substances 0.000 claims description 24
- 239000000706 filtrate Substances 0.000 claims description 18
- 238000001256 steam distillation Methods 0.000 claims description 16
- 241000213006 Angelica dahurica Species 0.000 claims description 15
- 244000292697 Polygonum aviculare Species 0.000 claims description 13
- 235000006386 Polygonum aviculare Nutrition 0.000 claims description 13
- 239000001569 carbon dioxide Substances 0.000 claims description 13
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 13
- 229940083961 cinnamomum camphora leaf extract Drugs 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 235000003717 Boswellia sacra Nutrition 0.000 claims description 9
- 240000007551 Boswellia serrata Species 0.000 claims description 9
- 235000012035 Boswellia serrata Nutrition 0.000 claims description 9
- 239000004863 Frankincense Substances 0.000 claims description 9
- 244000162475 Juniperus rigida Species 0.000 claims description 9
- 244000246386 Mentha pulegium Species 0.000 claims description 9
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 9
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 9
- 235000001050 hortel pimenta Nutrition 0.000 claims description 9
- 235000001282 nezumisashi Nutrition 0.000 claims description 9
- 244000050510 Cunninghamia lanceolata Species 0.000 claims description 8
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 claims description 6
- 230000000694 effects Effects 0.000 abstract description 23
- 208000024891 symptom Diseases 0.000 abstract description 22
- 206010039083 rhinitis Diseases 0.000 abstract description 16
- 206010011224 Cough Diseases 0.000 abstract description 12
- 201000007100 Pharyngitis Diseases 0.000 abstract description 11
- 210000004072 lung Anatomy 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract description 5
- 230000002588 toxic effect Effects 0.000 abstract description 5
- 241000050051 Chelone glabra Species 0.000 abstract description 4
- 230000003266 anti-allergic effect Effects 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 239000000419 plant extract Substances 0.000 abstract description 3
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 abstract 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 abstract 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 abstract 1
- -1 α firpenes Natural products 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 206010039101 Rhinorrhoea Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 210000001331 nose Anatomy 0.000 description 7
- 208000010753 nasal discharge Diseases 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241000723347 Cinnamomum Species 0.000 description 4
- 206010028748 Nasal obstruction Diseases 0.000 description 4
- 244000153955 Reynoutria sachalinensis Species 0.000 description 4
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 description 4
- 235000017803 cinnamon Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000125175 Angelica Species 0.000 description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010039085 Rhinitis allergic Diseases 0.000 description 3
- 201000010105 allergic rhinitis Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 208000017574 dry cough Diseases 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002345 respiratory system Anatomy 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 210000000621 bronchi Anatomy 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 239000007923 nasal drop Substances 0.000 description 2
- 229940100662 nasal drops Drugs 0.000 description 2
- 210000002850 nasal mucosa Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- OCJLPZCBZSCVCO-UHFFFAOYSA-N 2-propylcyclohexan-1-one Chemical compound CCCC1CCCCC1=O OCJLPZCBZSCVCO-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 240000005636 Dryobalanops aromatica Species 0.000 description 1
- 206010015719 Exsanguination Diseases 0.000 description 1
- 244000299452 Gouania lupuloides Species 0.000 description 1
- 235000000292 Gouania lupuloides Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021703 Indifference Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002526 isomenthone derivatives Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 239000005418 vegetable material Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/022—Refining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Otolaryngology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of smooth breathing essential oil, including following raw material components：The different menthyl ester of d-limonen, eudesmol, sabinene, o-cymene, menthol, menthones, beta pinene, linalool, acetic acid, α firpenes, isomenthone and terpinyl acetate.Each raw material components are well mixed, essential oil is obtained；Essential oil is applied to throat afterwards.The smooth breathing essential oil that the present invention is provided is formed from the plant extract containing active skull cap components, prescription matches science, without any artificial synthesis group point, safe without toxic side effect, and have effects that excellent clear haze dredging collateral, antiallergic facilitaing lung, logical nose stop tears, smooth throat to stop cough and enhancing body immunity, it can effectively alleviate and cure pharyngitis, rhinitis and improve the symptoms such as cough caused by haze.In addition, the essential oil of the invention provided is evident in efficacy, stability is good, easy to use, it is with a wide range of applications.
Description
Technical field
The present invention relates to cosmetic technical field, and in particular to a kind of smooth breathing essential oil and preparation method and application.
Background technology
As China industrializes the quickening with Development of China's Urbanization, problem of environmental pollution is increasingly serious；Its Air Contamination is outstanding
To be serious, especially haze weather is multiple in recent years, and scope is wide and lasts length.It is well known that haze can be directly entered and adsorb
In human body lower respiratory tract and the lobe of the lung, larger is injured to health.In numerous air pollution source, lung particulate matter quantity
Increasing with ratio, the fine particle (main component of haze) that particle diameter is less than 2.5 μm is difficult to, by mouth mask and nose stop, be inhaled
Bronchus can be directly entered by entering after human body, cause respiratory tract infection, and serious wound can be caused to the body of people by blocking capillary bronchus
Evil, such as suction for a long time, influence oxygen take the photograph oxygen conversion with blood, and severe patient causes blood circulation system poisoning anoxic, and then is susceptible to suffer from
A variety of diseases such as pharyngitis, rhinitis, tracheitis, asthma and other more serious diseases for example lung cancer, hypertension, heart disease, heart infarction,
Cerebral thrombus, sudden death of heart disease and senile dementia etc..For current severe environment situation, government is optimizing and revising energy knot always
Structure, development cleaning green energy resource, accelerates the process of energy substitution, but control the Endless Way of haze.At the same time, the common people are adopted for anti-haze
Some external measures have been taken, has such as worn masks, air purifier is installed, but this is the interim measure of of short duration protection, is received
Imitate little, generation that itself the anti-clear haze immunity of haze is not improved, disease remains unchanged.
In addition, as the common disease of the infection of the upper respiratory tract and the rhinitis of frequently-occurring disease and pharyngitis, normal protracted course of disease, and can be with
Cause multiple complications, harm health.Rhinitis is schneiderian membrance or sub-mucosal tissues because viral infection, courses of infection, stimulant
Stimulate etc., cause schneiderian membrance or sub-mucosal tissues to be damaged caused acute or chronic inflammation, rhinitis causes to produce excessive mucus,
Generally cause the symptoms such as runny nose, nasal obstruction；Pharyngitis is pharyngeal mucosa, the inflammation of submucous tissue, is often the one of the infection of the upper respiratory tract
Part, according to the length and the difference of pathological change property of the course of disease, is divided into acpuei pharyngitis, the major class of chronic pharyngitis two.Existing market
Although upper have the medicine for largely treating such symptom, still it is difficult to effect a radical cure.
Essential oil is also known as volatile oil, is widely present in various plants, and it has many bioactivity, in recent years,
Research and application of the essential oil in the industry such as medicine, food, tobacco and wine, detergents and cosmetic are increasing, in answering for pharmaceutical sanitary field
With also more and more concerned.Based on this there is provided it is a kind of can effectively alleviate and cure pharyngitis and rhinitis, improve haze caused by
The essential oil of the symptoms such as cough is particularly important.
The content of the invention
For defect of the prior art, the present invention is intended to provide a kind of smooth breathing essential oil and preparation method and application.
The essential oil that the present invention is provided is formed from the plant extract containing active skull cap components, prescription proportioning science, without anyone
Work synthesizes component, safe without toxic side effect, and with excellent clear haze dredging collateral, antiallergic facilitaing lung, logical nose stop tears, smooth throat to stop cough and
Strengthen body immunity effect, can effectively alleviate and cure pharyngitis and rhinitis, improve haze caused by cough symptom.This
Outside, the essential oil that provides of the present invention is evident in efficacy, stability is good, easy to use, is with a wide range of applications.
Therefore, the present invention provides following technical scheme：
In a first aspect, the present invention provides a kind of essential oil, raw material components by weight, including：D-limonen 20-25 weights
Measure part, it is eudesmol 15-25 parts by weight, sabinene 1-3 parts by weight, o-cymene 1-3 parts by weight, menthol 10-15 parts by weight, thin
Lotus ketone 5-10 parts by weight, nopinene 2-5 parts by weight, linalool 2-5 parts by weight and the different menthyl ester 1-3 parts by weight of acetic acid.
In the further embodiment of the present invention, in addition to：Australene 17-21 parts by weight, isomenthone 2-4 parts by weight
And terpinyl acetate 2-5 parts by weight.Specifically, menthones and isomenthone isomers each other, menthones is that 5- methyl -2- is different
Propylcyclohexanone, No. CAS is 10458-14-7；Isomenthone is 5- methyl -2- (1- Methylethyls) cyclohexanone, and No. CAS is
491-07-6。
In the further embodiment of the present invention, including：The parts by weight of d-limonen 23, the parts by weight of eudesmol 20,
The parts by weight of sabinene 2, the parts by weight of o-cymene 2, the parts by weight of menthol 12, the parts by weight of menthones 7, the parts by weight of nopinene 4, linalool
The different parts by weight of menthyl ester 2 of 3 parts by weight, acetic acid, the parts by weight of australene 19, the parts by weight of isomenthone 3, the parts by weight of terpinyl acetate 3.
In the further embodiment of the present invention, raw material components also include：Gentrin Knotweed P.E 7-10 parts by weight, yellow cinnamon leaf
Extract 1-2 parts by weight and Angelica Dahurica extract 2-4 parts by weight.It should be noted that Gentrin Knotweed P.E, cinnamomum camphora in the present invention
Leaf extract and Angelica Dahurica extract can be selected from commercially available prod, can also be made by oneself according to following methods of the present invention；Specifically, it is brave
The preparation method of cane extract includes：It is soaked in water after giant knotweed is crushed, mass percentage concentration is used afterwards for 55%-60%'s
Ethanol water makees extractant, extracts 80min-100min under conditions of temperature is 75 DEG C -80 DEG C, filters afterwards and collect filter
Liquid, obtains Gentrin Knotweed P.E.The preparation method of Angelica Dahurica extract includes：It is soaked in water after the root of Dahurain angelica is crushed, afterwards using quality
Percentage concentration makees extractant for 15%-20% aqueous acetic acid, and 30min- is extracted under conditions of temperature is 55 DEG C -65 DEG C
50min, filters and collects filtrate, obtain Angelica Dahurica extract afterwards.The preparation method of cinnamomum camphora leaf extract includes：By yellow cinnamon leaf powder
Mass percentage concentration is used to make extractant for 35%-55% ethanol water after broken, under conditions of temperature is 60 DEG C -70 DEG C
To extracting 20min-30min, cinnamomum camphora leaf extract is obtained.
Second aspect, the present invention provides a kind of preparation method of essential oil, comprises the following steps：S101：By bay, silver-colored China fir and
You Jiali carries out first using supercritical carbon dioxide after crushing and extracted；S102：After flores aurantii, needle juniper, frankincense and peppermint are crushed
It is well mixed, carry out second using steam distillation afterwards and extract, the product after second is extracted afterwards filters and collects the
Two filtrates；S103：The product that S101 is obtained is well mixed with the product that S102 is obtained, and obtains essential oil.It should be noted that water
The steam distillation genealogy of law refers to the vegetable material containing volatile ingredient and water condistillation, volatile ingredient is evaporated in the lump with vapor
Go out, condensed point take volatile ingredient leach extraction method；Those skilled in the art carry out steam distillation using usual manner
.The present invention selects Australia You Jiali.
In the further embodiment of the present invention, in S101, the first temperature extracted is 45 DEG C -48 DEG C, and pressure is
13.70MPa-17.80MPa, the time is 50min-100min, and the flow velocity of supercritical carbon dioxide is 25kg/h-35kg/h.
In the further embodiment of the present invention, in S102, the time of steam distillation is 100min-300min, water
Addition quality with crush after the ratio between flores aurantii, needle juniper, the gross mass of frankincense and peppermint be (3-5)：1；And collect the second filtrate it
Also include afterwards：The pH value for adjusting the second filtrate is 7.3-7.5.
The third aspect, the application method for the essential oil that the present invention is provided, throat is applied to by essential oil.
The above-mentioned technical proposal of the present invention has advantages below compared with prior art：
(1) applicant has found by numerous studies：The essential oil that the present invention is provided selects the plant containing active skull cap components
Extraction is formed, prescription proportioning science, without any artificial synthesis group point, safe without toxic side effect, and has excellent clear haze
Dredging collateral, antiallergic facilitaing lung, logical nose stop tears, smooth throat to stop cough and strengthen effect of body immunity, can effectively alleviate and cure pharyngitis
With the cough symptom caused by rhinitis, improvement haze.
(2) essential oil that the method provided using the present invention is prepared, it is real through Efficacy experiments, toxicological test and stability
Test, have no toxic side effect, evident in efficacy, instant effect, stability it is good and easy to use, be with a wide range of applications.
(3) preparation method of essential oil provided using the present invention, can retain to greatest extent each bulk drug activity into
While dividing, the active ingredient in each raw medicinal material can be fully discharged, so that the essential oil tool finally prepared
There is excellent effect.
(4) the preparation method process stabilizing for the essential oil that the present invention is provided, yield are high, quality is good, energy consumption is low, raw material are wide
General, process is simply saved；Production can be completed using existing equipment, equipment requirement is reduced, to zero environmental.
(5) essential oil that the present invention is provided is easy to use, directly smears throat, and massage absorbs, you can reach excellent
Curative effect.In addition, for patients with rhinitis, essential oil can also be dripped in nasal cavity.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
The embodiment to technical solution of the present invention is described in detail below.Following examples are only used for clearer
Explanation technical scheme, therefore be only used as example, and can not be limited the scope of the invention with this.
Experimental method in following embodiments, is conventional method unless otherwise specified.
Test material used, is to be commercially available from conventional reagent shop unless otherwise specified in following embodiments.
Quantitative test in following examples, is respectively provided with three repetition experiments, and data are the average value of three repetition experiments
Or mean+SD.
Bay used in following embodiments, silver-colored China fir, You Jiali, flores aurantii, needle juniper, frankincense, peppermint, giant knotweed, yellow cinnamon leaf and
The root of Dahurain angelica meets the pertinent regulations under each medicinal material of text of Chinese Pharmacopoeia (version in 2015).Before feeding intake, pass through identification, each taste
Medicinal material material object is consistent with title, and quality meets standard.In addition, in embodiment five and embodiment ten, Gentrin Knotweed P.E is purchased from Shaanxi
Normal celestial movement biochemical technology Co., Ltd, cinnamomum camphora leaf extract and Angelica Dahurica extract match the limited public affairs of biotechnology difficult to understand purchased from Xi'an
Department.
The present invention provides a kind of essential oil, raw material components by weight, including：D-limonen 20-25 parts by weight, folium eucalypti
Oleyl alcohol 15-25 parts by weight, sabinene 1-3 parts by weight, o-cymene 1-3 parts by weight, menthol 10-15 parts by weight, menthones 5-10
Parts by weight, nopinene 2-5 parts by weight, linalool 2-5 parts by weight and the different menthyl ester 1-3 parts by weight of acetic acid.
Preferably, in addition to：Australene 17-21 parts by weight, isomenthone 2-4 parts by weight and terpinyl acetate 2-5 weights
Measure part.
Preferably, in addition to：Gentrin Knotweed P.E 7-10 parts by weight, cinnamomum camphora leaf extract 1-2 parts by weight and the root of Dahurain angelica are extracted
Thing 2-4 parts by weight.
In addition, for the essential oil of the present invention, can be by directly buying each raw material components in above-mentioned essential oil, then by it
It is well mixed, you can to obtain essential oil；The following methods that can also be provided using the present invention are prepared.
The present invention provides a kind of preparation method of essential oil, comprises the following steps：
S101：First is carried out after bay, silver-colored China fir and You Jiali are crushed using supercritical carbon dioxide to extract.Wherein,
One temperature extracted is 45 DEG C -48 DEG C, and pressure is 13.70MPa-17.80MPa, and the time is 50min-100min, overcritical dioxy
The flow velocity for changing carbon is 25kg/h-35kg/h.
S102：Will flores aurantii, needle juniper, frankincense and peppermint crush after be well mixed, carry out the using steam distillation afterwards
Two extract, and the product after second is extracted afterwards filters and collects the second filtrate.Wherein, the time of steam distillation is
Also include after 100min-300min, and the second filtrate of collection：The pH value for adjusting the second filtrate is 7.3-7.5.
S103：The product that S101 is obtained is well mixed with the product that S102 is obtained, and obtains essential oil.
Illustrated with reference to embodiment：
Embodiment one
The present invention provides a kind of essential oil, is made up of following raw material components：The parts by weight of d-limonen 20, the weight of eudesmol 25
Measure part, the parts by weight of sabinene 1, the parts by weight of o-cymene 3, the parts by weight of menthol 10, the parts by weight of menthones 10, the parts by weight of nopinene 2,
The parts by weight of linalool 5 and the different parts by weight of menthyl ester 1 of acetic acid；Above-mentioned each raw material components are well mixed, essential oil is obtained.
Embodiment two
The present invention provides a kind of essential oil, is made up of following raw material components：The parts by weight of d-limonen 23, the weight of eudesmol 20
Measure part, the parts by weight of sabinene 2, the parts by weight of o-cymene 2, the parts by weight of menthol 12, the parts by weight of menthones 7, the parts by weight of nopinene 4,
The different parts by weight of menthyl ester 2 of the parts by weight of linalool 3, acetic acid；Above-mentioned each raw material components are well mixed, essential oil is obtained.
Embodiment three
The present invention provides a kind of essential oil, is made up of following raw material components：The parts by weight of d-limonen 20, the weight of eudesmol 25
Measure part, the parts by weight of sabinene 1, the parts by weight of o-cymene 3, the parts by weight of menthol 10, the parts by weight of menthones 10, the parts by weight of nopinene 2,
The parts by weight of linalool 5 and the different parts by weight of menthyl ester 1 of acetic acid, the parts by weight of australene 17, the parts by weight of isomenthone 4 and acetic acid pine
The parts by weight of grease 2；Above-mentioned each raw material components are well mixed, essential oil is obtained.
Example IV
The present invention provides a kind of essential oil, is made up of following raw material components：The parts by weight of d-limonen 23, the weight of eudesmol 20
Measure part, the parts by weight of sabinene 2, the parts by weight of o-cymene 2, the parts by weight of menthol 12, the parts by weight of menthones 7, the parts by weight of nopinene 4,
The different parts by weight of menthyl ester 2 of the parts by weight of linalool 3, acetic acid, the parts by weight of australene 19, the parts by weight of isomenthone 3, terpinyl acetate 3
Parts by weight；Above-mentioned each raw material components are well mixed, essential oil is obtained.
Embodiment five
The present embodiment changes relative parameters setting on the basis of example IV.
The present invention provides a kind of essential oil, is made up of following raw material components：The parts by weight of d-limonen 23, the weight of eudesmol 20
Measure part, the parts by weight of sabinene 2, the parts by weight of o-cymene 2, the parts by weight of menthol 12, the parts by weight of menthones 7, the parts by weight of nopinene 4,
The different parts by weight of menthyl ester 2 of the parts by weight of linalool 3, acetic acid, the parts by weight of australene 19, the parts by weight of isomenthone 3, terpinyl acetate 3
Parts by weight, the parts by weight of Gentrin Knotweed P.E 10, the parts by weight of cinnamomum camphora leaf extract 2 and the parts by weight of Angelica Dahurica extract 3；By above-mentioned each original
Expect that component is well mixed, obtain essential oil.It should be noted that Gentrin Knotweed P.E, cinnamomum camphora leaf extract in the present embodiment and white
Root of Dahurian angelica extract is selected from commercially available prod.
Embodiment six
The present embodiment changes relative parameters setting on the basis of embodiment five.
The present invention provides a kind of essential oil, is made up of following raw material components：The parts by weight of d-limonen 23, the weight of eudesmol 20
Measure part, the parts by weight of sabinene 2, the parts by weight of o-cymene 2, the parts by weight of menthol 12, the parts by weight of menthones 7, the parts by weight of nopinene 4,
The different parts by weight of menthyl ester 2 of the parts by weight of linalool 3, acetic acid, the parts by weight of australene 19, the parts by weight of isomenthone 3, terpinyl acetate 3
Parts by weight, the parts by weight of Gentrin Knotweed P.E 10, the parts by weight of cinnamomum camphora leaf extract 2 and the parts by weight of Angelica Dahurica extract 3；By above-mentioned each original
Expect that component is well mixed, obtain essential oil.It should be noted that Gentrin Knotweed P.E, cinnamomum camphora leaf extract in the present embodiment and white
The method self-control that root of Dahurian angelica extract is provided using the present invention.Specifically, the preparation method of Gentrin Knotweed P.E includes：After giant knotweed is crushed
It is soaked in water, uses mass percentage concentration to make extractant for 55% ethanol water afterwards, under conditions of temperature is 80 DEG C
80min is extracted, filters afterwards and collects filtrate, obtain Gentrin Knotweed P.E.The preparation method of Angelica Dahurica extract includes：By angelica dahurica powder
It is soaked in water after broken, uses mass percentage concentration to make extractant for 20% aqueous acetic acid afterwards, in the bar that temperature is 55 DEG C
30min is extracted under part, filters afterwards and collects filtrate, obtain Angelica Dahurica extract.The preparation method of cinnamomum camphora leaf extract includes：Will
Yellow cinnamon leaf uses mass percentage concentration to make extractant for 35% ethanol water after crushing, right under conditions of temperature is 70 DEG C
20min is extracted, cinnamomum camphora leaf extract is obtained.
In addition, also specifically there is implementation below in the preparation method of the essential oil provided according to the present invention：
Embodiment seven
The present invention provides a kind of preparation method of essential oil, comprises the following steps：
S101：First is carried out after bay, silver-colored China fir and You Jiali are crushed using supercritical carbon dioxide to extract；Wherein,
One temperature extracted is 48 DEG C, and pressure is 15.80MPa, and the time is 80min, and the flow velocity of supercritical carbon dioxide is 30kg/h.
S102：Will flores aurantii, needle juniper, frankincense and peppermint crush after be well mixed, carry out the using steam distillation afterwards
Two extract, and the product after second is extracted afterwards filters and collects the second filtrate；Wherein, the time of steam distillation is
300min, the addition quality of water and the mass ratio of product after crushing are 5：1.
S103：The product that S101 is obtained is well mixed with the product that S102 is obtained, and obtains essential oil.
Embodiment eight
The present invention provides a kind of preparation method of essential oil, comprises the following steps：
S101：First is carried out after bay, silver-colored China fir and You Jiali are crushed using supercritical carbon dioxide to extract；Wherein,
One temperature extracted is 45 DEG C, and pressure is 17.50MPa, and the time is 50min, and the flow velocity of supercritical carbon dioxide is 25kg/h.
S102：Will flores aurantii, needle juniper, frankincense and peppermint crush after be well mixed, carry out the using steam distillation afterwards
Two extract, and the product after second is extracted afterwards filters and collects the second filtrate；Wherein, the time of steam distillation is
100min, the addition quality of water and the mass ratio of product after crushing are 3：1.
S103：The product that S101 is obtained is well mixed with the product that S102 is obtained, and obtains essential oil.
Embodiment nine
The present embodiment changes relevant parameter on the basis of embodiment eight.
The present invention provides a kind of preparation method of essential oil, comprises the following steps：
S101：First is carried out after bay, silver-colored China fir and You Jiali are crushed using supercritical carbon dioxide to extract；Wherein,
One temperature extracted is 45 DEG C, and pressure is 17.50MPa, and the time is 50min, and the flow velocity of supercritical carbon dioxide is 25kg/h.
S102：Will flores aurantii, needle juniper, frankincense and peppermint crush after be well mixed, carry out the using steam distillation afterwards
Two extract, and the product after second is extracted afterwards filters and collects the second filtrate, and the pH value that the second filtrate is adjusted afterwards is 7.5；
Wherein, the time of steam distillation is 100min, and the addition quality of water and the mass ratio of product after crushing are 3：1.
S103：The product that S101 is obtained is well mixed with the product that S102 is obtained, and obtains essential oil.
Embodiment ten
The present embodiment changes relevant parameter on the basis of embodiment nine.
The present invention provides a kind of preparation method of essential oil, comprises the following steps：
S101：First is carried out after bay, silver-colored China fir and You Jiali are crushed using supercritical carbon dioxide to extract；Wherein,
One temperature extracted is 45 DEG C, and pressure is 17.50MPa, and the time is 50min, and the flow velocity of supercritical carbon dioxide is 25kg/h.
S102：Will flores aurantii, needle juniper, frankincense and peppermint crush after be well mixed, carry out the using steam distillation afterwards
Two extract, and the product after second is extracted afterwards filters and collects the second filtrate, and the pH value that the second filtrate is adjusted afterwards is 7.5；
Wherein, the time of steam distillation is 100min, and the addition quality of water and the mass ratio of product after crushing are 3：1.
S103：The product that S101 is obtained is well mixed with the product that S102 is obtained；The giant knotweed with 7 parts by weight is extracted afterwards
The Angelica Dahurica extract of thing, the cinnamomum camphora leaf extract of 1 parts by weight and 2 parts by weight is well mixed, and obtains essential oil.It should be noted that
Gentrin Knotweed P.E, cinnamomum camphora leaf extract and Angelica Dahurica extract in the present embodiment are selected from commercially available prod.
In addition, effect in order to preferably evaluate each embodiment essential oil, carries out following test：
First, toxicity test
The small white mouse 200 (each 100 of male and female) for selecting body weight to be 18-22g, is divided into 10 groups, each 10 of every group of male and female, little Bai
Mouse back unhairing exposes exocuticle, unhairing scope 2cm × 2cm, first group to third component do not smear the embodiment of the present invention one to
The essential oil that embodiment ten is prepared, dosage is 5g, successive administration 30 days.When during administration and 1 week after drug withdrawal, observation is white
Mouse growth conditions and activity and diet, identification hematology, blood biochemical analysis, organ tissue structure and routine urinalysis etc..As a result find
The health existence of all small white mouses, it is without any side effects；Anatomic observation blood picture, liver function, each organs and tissues state are and normal
Small white mouse compares indifference.It is demonstrated experimentally that the essential oil that the present invention is provided is nontoxic, drug safety is reliable.
2nd, the sign of each embodiment essential oil performance
(1) measure of each embodiment derived essential oil
Specifically, derived essential oil of the embodiment seven into embodiment ten is detected using GC-MS methods, and by each embodiment
Main component is listed in Tables 1 and 2：
Each embodiment derived essential oil list one of table 1
Each embodiment derived essential oil list two of table 2
(2) each embodiment essential oil is alleviating effect in being coughed caused by haze
The volunteer 1000 for collecting haze high-incidence season frequent outdoor study in the winter time, each patient is without the adjoint of degree
There is pharyngeal uncomfortable, dry cough or there are the symptoms such as phlegm.Specifically, each patient is divided into 10 groups, every group 100.By first group to
Ten groups try out the embodiment of the present invention one and embodiment ten respectively essential oil two weeks, 2 times a day (once in the morning and once at night), each 3g；
Curative effect is observed when trying out the 3rd day, the 7th day and the 15th day, it is specific as shown in table 3.
Outcome measure is：
Cure：Pharyngeal uncomfortable, dry cough has the disappearance of the symptoms such as phlegm.Take a turn for the better：Pharyngeal uncomfortable, dry cough has the symptoms such as phlegm
Improve.It is invalid：Symptom is without changer.
Specifically smearing method is：Essential oil is directly applied to throat, absorption is massaged into.
The effect statistical form of each embodiment essential oil of table 3
(3) effect of each embodiment essential oil in cavy Rhinitis Symptoms are alleviated
Using the outstanding methods of domestic Zhao Xiu, (Zhao Xiujie, Dong Zhen, poplar account for spring Nasal hypersensitivities experimental model and set up the Chinese ears of [J]
Nose specialty of pharyngolaryngology magazine .1993,28 (1)：17.) cavy allergic rhinitis animal model is set up, on the basis of modeling type is successful,
Healthy guinea pig 120 is selected, body weight 280-320g, each 60 of male and female divide 10 groups (each 5 of every group of male and female) at random, are respectively just
Normal group, model group and experimental group 1-10.The next day of being changed to after modeling success, is excited 1 time (maintenance), and model group was reinstated from the 11st day
Physiological saline collunarium；Experimental group 1-10 tries out the essential oil that embodiment one is prepared to embodiment ten respectively, carries out nose dropping treatment,
Per side each 1g of nasal cavity, one time a day, treats 10 days.All animals sacrificed by exsanguination after being anaesthetized after last is excited 30 minutes, and immediately
Bilateral schneiderian membrane is taken, side schneiderian membrane is put into 10% neutral formalin solution to fixed, FFPE after 1 week at random.
For the cavy after above-mentioned processing, observe cavy sniffle and given a mark by table 4 and add up total score.Observing time
For：After modeling success the 10th day after the 1st Nasal Drops, after Nasal Drops in 30min.Symptom integral such as table before and after each group administration
Shown in 5.
The guinea pig experimental compliance Rhinitis Symptoms standards of grading of table 4
Symptom integral compares (part, ± S) before and after the administration of each group of table 5
| Group | N/ is only | Symptom integral before administration | Symptom integral after administration |
| Normal group | 10 | 0.60±0.71 | 0.63±0.52 |
| Model group | 10 | 6.38±0.59 | 6.58±0.63 |
| Embodiment one | 10 | 6.35±0.73 | 1.73±0.98 |
| Embodiment two | 10 | 6.39±0.65 | 1.70±0.89 |
| Embodiment three | 10 | 6.52±0.51 | 1.53±0.75 |
| Example IV | 10 | 6.50±0.92 | 1.51±0.59 |
| Embodiment five | 10 | 6.58±0.43 | 1.42±0.68 |
| Embodiment six | 10 | 6.59±0.39 | 1.40±0.52 |
| Embodiment seven | 10 | 6.64±0.52 | 1.35±0.49 |
| Embodiment eight | 10 | 6.71±0.39 | 1.38±0.50 |
| Embodiment nine | 10 | 6.75±0.81 | 1.29±0.48 |
| Embodiment ten | 10 | 6.68±0.49 | 1.27±0.61 |
(4) effect of each embodiment essential oil in human body Rhinitis Symptoms are alleviated
Specifically, collection Allergic Rhinitis and each symptom 500, occurred patient of turbid nasal discharge patients with rhinitis more
Including intermittent and alternately nasal obstruction, rhiocnesmus, many tears, clear nasal discharge, smell decline, headache or dizzy.Each patient is divided into 10 groups,
Every group 100 (Allergic Rhinitis and each 50 of turbid nasal discharge patients with rhinitis).First group to the tenth group is tried out respectively
The essential oil two weeks of the embodiment of the present invention one and embodiment ten, 2 times a day (once in the morning and once at night, nose dropping treatment), each 1g；Observation
Curative effect, it is specific as shown in table 6.
Outcome measure is：
It is effective：The symptoms such as nasal obstruction, rhiocnesmus, many tears, clear nasal discharge, smell decline, headache or giddy are significantly improved；Take a turn for the better：Nasal obstruction,
The symptoms such as rhiocnesmus, many tears, clear nasal discharge, smell decline, headache or giddy have taken a turn for the better；It is invalid：Symptom is without improvement.
Each embodiment essential oil of table 6 treats the clinical test statistical form of rhinitis
Certainly, except the situation that embodiment one is enumerated to embodiment ten, the species and percentage by weight of other raw material components,
Condition and parameter in preparation process etc. are also possible.
The essential oil that the present invention is provided is formed from the plant extract containing active skull cap components, prescription proportioning science, is not added
Plus any artificial synthesis group point, safe without toxic side effect, and stop tears, relieving sore-throat with excellent clear haze dredging collateral, antiallergic facilitaing lung, logical nose
Cough-relieving and strengthen body immunity effect, can effectively alleviate and cure pharyngitis and rhinitis, improve haze caused by cough
Symptom.In addition, the essential oil of the invention provided is evident in efficacy, stability is good, easy to use, it is with a wide range of applications.
In the description of this specification, it is to be understood that reference term " one embodiment ", " some embodiments ", " show
The description of example ", " specific example " or " some examples " etc. mean to combine the specific features of the embodiment or example description, structure,
Material or feature are contained at least one embodiment of the present invention or example.In this manual, above-mentioned term is shown
The statement of meaning property is necessarily directed to identical embodiment or example.Moreover, specific features, structure, material or the spy of description
Point can in an appropriate manner be combined in any one or more embodiments or example.In addition, in the case of not conflicting,
Those skilled in the art can be by the not be the same as Example or example and non-be the same as Example described in this specification or example
Feature is combined and combined.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (9)
1. a kind of essential oil, it is characterised in that raw material components by weight, including：
D-limonen 20-25 parts by weight, eudesmol 15-25 parts by weight, sabinene 1-3 parts by weight, o-cymene 1-3 weight
Part, menthol 10-15 parts by weight, menthones 5-10 parts by weight, nopinene 2-5 parts by weight, linalool 2-5 parts by weight and acetic acid
Different menthyl ester 1-3 parts by weight.
2. essential oil according to claim 1, it is characterised in that also include：
Australene 17-21 parts by weight, isomenthone 2-4 parts by weight and terpinyl acetate 2-5 parts by weight.
3. essential oil according to claim 2, it is characterised in that including：
The parts by weight of d-limonen 23, the parts by weight of eudesmol 20, the parts by weight of sabinene 2, the parts by weight of o-cymene 2, menthol 12
Parts by weight, the parts by weight of menthones 7, the parts by weight of nopinene 4, the parts by weight of linalool 3, the different parts by weight of menthyl ester 2 of acetic acid, australene 19
Parts by weight, the parts by weight of isomenthone 3, the parts by weight of terpinyl acetate 3.
4. the essential oil according to claim any one of 1-3, it is characterised in that also include：
Gentrin Knotweed P.E 7-10 parts by weight, cinnamomum camphora leaf extract 1-2 parts by weight and Angelica Dahurica extract 2-4 parts by weight.
5. the preparation method of essential oil described in a kind of claim 2, it is characterised in that comprise the following steps：
S101：First is carried out after bay, silver-colored China fir and You Jiali are crushed using supercritical carbon dioxide to extract；
S102：It is well mixed after flores aurantii, needle juniper, frankincense and peppermint are crushed, carrying out second using steam distillation afterwards carries
Take, the product after described second is extracted filters and collects the second filtrate；
S103：The product that the S101 is obtained is well mixed with the obtained products of the S102, obtains essential oil.
6. the preparation method of essential oil according to claim 5, it is characterised in that：
In the S101, the described first temperature extracted is 45 DEG C -48 DEG C, and pressure is 13.70MPa-17.80MPa, and the time is
50min-100min, the flow velocity of supercritical carbon dioxide is 25kg/h-35kg/h.
7. the preparation method of essential oil according to claim 5, it is characterised in that：
In the S102, the time of the steam distillation is 100min-300min.
8. the preparation method of essential oil according to claim 5, it is characterised in that：
In the S102, also include after collection second filtrate：The pH value for adjusting second filtrate is 7.3-7.5.
9. according to the application method of any one of the claim 1-4 essential oils, it is characterised in that：The essential oil is applied to throat
Position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710249758.2A CN107129869A (en) | 2017-04-17 | 2017-04-17 | Smooth breathing essential oil and preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710249758.2A CN107129869A (en) | 2017-04-17 | 2017-04-17 | Smooth breathing essential oil and preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107129869A true CN107129869A (en) | 2017-09-05 |
Family
ID=59714945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710249758.2A Pending CN107129869A (en) | 2017-04-17 | 2017-04-17 | Smooth breathing essential oil and preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107129869A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078975A (en) * | 2017-12-29 | 2018-05-29 | 北京九和药业有限公司 | Application of the pharmaceutical composition containing eucalyptol, limonene and australene in the drug for preparing treatment upper respiratory tract bacterium infection |
| CN112057513A (en) * | 2020-09-10 | 2020-12-11 | 颇黎芳香医药科技（上海）有限公司 | Respiratory system conditioning essential oil and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060003030A1 (en) * | 2004-07-01 | 2006-01-05 | Lin Chun-Ying | Essential oils for treating and/ or preventing allergic disease |
| CN102048828A (en) * | 2009-11-10 | 2011-05-11 | 天津药物研究院 | Biond magnolia flower oil capsules for treating rhinitis and preparation process thereof |
| CN102319292A (en) * | 2011-08-04 | 2012-01-18 | 张玲环 | The essential oil component and the application thereof of treatment rhinitis |
| CN104257752A (en) * | 2014-10-09 | 2015-01-07 | 成都市康飞药业有限公司 | Medicinal composition for treating rhinitis and application thereof |
-
2017
- 2017-04-17 CN CN201710249758.2A patent/CN107129869A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060003030A1 (en) * | 2004-07-01 | 2006-01-05 | Lin Chun-Ying | Essential oils for treating and/ or preventing allergic disease |
| CN102048828A (en) * | 2009-11-10 | 2011-05-11 | 天津药物研究院 | Biond magnolia flower oil capsules for treating rhinitis and preparation process thereof |
| CN102319292A (en) * | 2011-08-04 | 2012-01-18 | 张玲环 | The essential oil component and the application thereof of treatment rhinitis |
| CN104257752A (en) * | 2014-10-09 | 2015-01-07 | 成都市康飞药业有限公司 | Medicinal composition for treating rhinitis and application thereof |
Non-Patent Citations (7)
| Title |
|---|
| 周育平主编: "《Office健康宝典》", 31 July 2005, 科学技术文献出版社 * |
| 春之霖等: "《花养女人：美丽一生幸福一生全书：超值全彩白金版》", 30 April 2015, 新疆科学技术出版社 * |
| 王羽梅: "《中国芳香植物精油成分手册（全三册）》", 31 May 2015, 华中科技大学出版社 * |
| 田燕等: "《中药临床新用途》", 30 June 2016, 金盾出版社 * |
| 蔡永敏: "《中药药名辞典》", 31 October 1996, 中国中医药出版社 * |
| 韩智强等: "GC-MS法分析姜科豆蔻属两种植物的挥发性成分", 《食品研究与开发》 * |
| 高学敏: "《中药学》", 31 March 2017, 中国中医药出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108078975A (en) * | 2017-12-29 | 2018-05-29 | 北京九和药业有限公司 | Application of the pharmaceutical composition containing eucalyptol, limonene and australene in the drug for preparing treatment upper respiratory tract bacterium infection |
| CN112057513A (en) * | 2020-09-10 | 2020-12-11 | 颇黎芳香医药科技（上海）有限公司 | Respiratory system conditioning essential oil and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103689010B (en) | Medicine for hog house disinfection | |
| CN102952635B (en) | Cigarette spice for enhancing fragrance and relaxing throat and application | |
| CN102198236A (en) | Chinese medicine composition for treating acute sinusitis and preparation method thereof | |
| CN104905405B (en) | The cigarette of the essence containing plant flavone mouth stick preparation method and application | |
| CN111419947A (en) | Folium artemisiae argyi compound essential oil capable of relieving throat pain and preparation method thereof | |
| CN100409882C (en) | Heat clearing and detoxicating drug for abating fever | |
| CN106421039A (en) | Traditional Chinese medicine composition for preventing and treating haze-caused diseases, preparation method thereof and mask containing traditional Chinese medicine | |
| CN114246925A (en) | Traditional Chinese medicine essential oil and application thereof | |
| CN102716223B (en) | Chinese medicinal composition for treating upper respiratory tract infection and preparation method thereof | |
| CN104381703A (en) | Dog food and preparation method thereof | |
| CN107129869A (en) | Smooth breathing essential oil and preparation method and application | |
| AU2002224268B2 (en) | Method and preparations having effect against allergic symptoms | |
| JP5406015B2 (en) | Preparations for the treatment of hand / foot tinea and methods for producing the same | |
| CN108523121A (en) | A kind of functional food and preparation method thereof of anti-haze clearing lung-heat | |
| KR101968890B1 (en) | Manufacturing method of a mask component containing smilax china leaf for improving breath function | |
| CN107549206A (en) | Expelling parasite, purification air, the composition to refresh the mind and its application and application method | |
| CN100553502C (en) | A kind of harmless cigarette | |
| CN103893737B (en) | Be used for the treatment of medicine of bronchial astehma and preparation method thereof | |
| CN105412281A (en) | Traditional Chinese medicinal composition for treating allergic asthma and preparation method thereof | |
| CN104887944A (en) | Biological agent with function of preventing and treating respiratory diseases caused by haze and preparation method of biological agent | |
| CN105661535B (en) | Composition for moistening lung, diminishing inflammation and preventing haze harm and preparation method thereof | |
| CN104957952B (en) | There is the rhamnus crenata sieb.et zucc. carpet of health care function of driving mosquitoes | |
| CN104206444B (en) | A kind of electric liquid device fragrant containing lavender natural and preparation method | |
| WO2021251617A1 (en) | Crude drug composition for alleviating or treating rhinitis, pharmacopuncture solution of oriental medicine comprising same, injection comprising same, and pharmacopuncturing method using same | |
| CN105343274A (en) | Drug combination having inflammation diminishing and cough relieving functions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |