A kind of composition of the pre- haze harm of moistening lung anti-inflammatory and preparation method thereof
Technical field
The present invention relates to field of health care products, the composition and its system of specifically a kind of pre- haze harm of moistening lung anti-inflammatory
Preparation Method.
Background technology
Haze is the mixture of mist and haze, wherein, mist is natural weather phenomenon, the steam generative forces of heaven and earth in air, although with dust
As the nuclei of condensation, but it is totally nontoxic.The core substance of haze is suspended in the substances such as cigarette, the dust in air, can directly into
Enter and be adhered in human body lower respiratory tract and the lobe of the lung, have injury to health.
With industrialized development, the pollutants such as dust, bacterium and virus in industrial waste gas, vehicle exhaust, air, all
It is attached in these hazes, is easy to cause acute upper respiratory infection (flu), acute tracheal bronchus after human body sucking
Scorching and pneumonia, asthma attack induce or aggravate chronic bronchitis etc..Analysis expert, PM2.5 (refer to that diameter is less than in air
Or the particulate matter equal to 2.5 microns, also referred to as lung particulate matter) absorption air inside toxicant, enter breathing
It after road, is absorbed by the body, is comprehensive to internal influence.In the past 30 years, China public smoking rate constantly declines, but lung
Cancer illness rate is but risen more than 4 times.Generally believe that this there may be certain relationship with haze sky increase at present.Many people
Haze weather metaphor becomes " smoking room " of the Nature.
Influence of the haze sky to human body cardiovascular and cerebrovascular disease is also very serious, can hinder normal blood circulation, lead to painstaking effort
Pipe disease, hypertension, coronary heart disease, cerebral hemorrhage, may induce angina pectoris, myocardial infarction, heart failure etc., go out chronic bronchitis
Existing cor pulmonale etc..Weather scientist and medical expert think that haze weather is to health as caused by fine particle
Harm is even than sandstorm bigger.The particulate matter of 10 microns of grain size or more can be blocked in outside the nose of people;Grain size is 2.5
Micron can enter the upper respiratory tract, but part can be excreted by sputum etc. to the particulate matter between 10 microns, also can be by nose
The villus blocking in intracavitary portion, it is relatively small to human health damage;And fine particle of the grain size below 2.5 microns is not easy to be hindered
Gear, bronchus can be directly entered after being inhaled into human body, interfere the gas exchanges of lung, and initiation includes asthma, bronchitis and the heart
The disease of blood vessel etc..Micronic dust into alveolar can be absorbed rapidly, be directly entered blood circulation without liver detoxification, point
For cloth to whole body, damage hemoglobin conveys the ability of oxygen, for the patient of anaemia and blood circulation disorder, it is possible to create serious
Consequence.The physiology mechanism of human body, which determines, does not have PM2.5 any filtering, obstruction ability, and harm of the PM2.5 to human health
But with the progress of medical technology, its terrified one side is gradually exposed.
At present, pre- haze or mitigation haze gradually increase a series of research of drugs such as human injury.Invention is special
Profit《A kind of Chinese medicine composition for treating respiratory tract infringement and preparation method thereof》(103127369 A of Publication No. CN) is disclosed
One kind also discloses preparation method with drug made of pure Chinese medicine.But ingredient campanulaceae, fritillaria thunbergii, the arhat of drug
Fruit and Radix Glycyrrhizae, are the known Chinese medicine with relieving cough and moistening lung effect, its function of the combination of this four medicines is also this four traditional Chinese medicine
The addition of drug effect is still to moisten the lung and relieve the cough, and can treat the breathing problem caused by haze to a certain extent.But this medicine
Fang Bingwei fundamentally solves infringement of the haze to entire human body.
Invention content
In view of the above deficiencies, the purpose of the present invention is to provide a kind of compositions of the pre- haze harm of moistening lung anti-inflammatory
And preparation method thereof.
To achieve the above object, technical program of the present invention lies in:A kind of composition of the pre- haze harm of moistening lung anti-inflammatory,
It counts in parts by weight, it includes honeysuckle and 10-15 parts of Fructus Monordicae extract, 3-5 parts of ginseng extract, needle mushroom and black fungus
30-50 parts of extract, 10-15 parts of cumquat juice, 5-10 parts of spirulina powder, 3-5 parts of chlorophyll, 3-5 parts of honey.
Preferably:The preparation method of the honeysuckle and Fructus Monordicae extract is as follows:Extracting honeysuckle 50- in parts by weight
60 parts and 40-50 parts of Siraitia grosvenorii, it is spare by moisture is filtered dry after honeysuckle and the cleaning of Siraitia grosvenorii flowing water;Siraitia grosvenorii is broken into pieces with one's fingers;It will be golden
The warm water constant temperature of 2 times of 40-60 DEG C of weight of honeysuckle flower and Siraitia grosvenorii impregnates half an hour;It is heated to boiling after immersion, boil 20-30 minutes
Afterwards, it filters, the water of filter residue 1 times of honeysuckle of addition and Siraitia grosvenorii original weight is taken to continue to be heated to boiling, after boiling 30-40 minutes,
Filtering continues to be heated to boiling, and be stirred continuously, it is spare that liquid extract is made after taking filtrate merging twice.
Preferably:The preparation method of the needle mushroom and black fungus extract is as follows:Needle mushroom 60- is taken in parts by weight
70 parts and 50-60 parts of black fungus;Fresh needle mushroom is removed into root, cleans up that be filtered dry moisture spare;Black fungus is soaked, is gone
Except the root base of a fruit, clean up that be filtered dry moisture spare;The needle mushroom handled well and black fungus are put into pulverizer to crush;After crushing
Needle mushroom and black fungus add in 50-70 DEG C of extraction 2-3h of pure water of 1 times of weight;Filtering, takes filtrate spare.
Preferably:The preparation method of the cumquat juice is as follows:Cumquat is cleaned up and is filtered dry water, is put into juice extractor squeezing
Take cumquat juice;The 50-60 DEG C of extraction 1-2h of pure water of cumquat filter residue using 0.2 times of weight is taken, filtering takes filtrate and former cumquat juice
Merge spare.
Preferably:Its molecular weight of the spirulina powder is less than 1000.
The present invention also provides a kind of preparation methods of the composition of the pre- haze harm of moistening lung anti-inflammatory, and operating procedure is such as
Under:
(1) by 50-60 DEG C of 30-50 portions of needle mushrooms and black fungus extract filtrate constant temperature, 10-15 portions of honeysuckles and sieve are added in
Chinese berry extract liquid extract, stirring evenly is completely dissolved honeysuckle and Fructus Monordicae extract liquid extract, forms solution a;
(2) 3-5 parts of honey are added in solution a, are stirred evenly, form solution b;
(3) 3-5 parts of ginseng extracts are added in solution b, are stirred evenly, form solution c;
(4) 5-10 parts of spirulina powders are added in 10-15 parts of cumquat juice, are stirred evenly, form solution d;
(5) solution c with solution d is uniformly mixed, forms solution e;
(6) 3-5 parts of chlorophyll are added in solution e under dark conditions, obtain the composition of pre- haze harm.
Wherein, chlorophyll liquid of the chlorophyll for the Swisse of Australia's production.
The beneficial effects of the present invention are:
Honeysuckle is sweet in flavor, cold in nature, has the function of clearing heat and detoxicating, dispelling wind and heat from the body, dredges throat, while to the thin of respiratory tract
Bacterium and virus have obvious inhibiting effect.Honeysuckle also has the immune function of certain enhancing.
Siraitia grosvenorii is sweet in flavor, cool in nature, has the function of clearing lung-heat ease constipation, while can also preventing respiratory tract infection.
Ginseng is sweet in flavor, slight bitter, slightly warm in nature, returns spleen, lung, the heart, kidney channel, gas Xiong Tirun, rises more than drop, has invigorating qi for relieving desertion,
The effect of strengthening spleen and tonifying lung, calming heart intelligence development, nourishes blood and promotes the production of body fluid.
Needle mushroom sweet-salty, it is cold in nature, enter liver, stomach, tonifying liver, beneficial stomach, anticancer.Contain dimension in every 100 grams of fresh needle mushrooms
Raw 53.9 milligrams of element B2,10.9 milligrams of vitamin C;Containing 13 grams of protein, carbohydrate 52 in every 100 grams of dry needle mushrooms
Gram, 7.56 grams of minerals.It is in addition, also fast containing carrotene, a variety of amino acid, phytohemagglutin phytolectin, polysaccharide, taurine, mushroom
Cry of certain animals, Radix Ophiopogonis sterol, cell dissolution toxin, dried mushroom cytotoxin etc..Needle mushroom have it is antifatigue, anti-inflammatory, boost metabolism
Effect.
Black fungus contains abundant plant collagen ingredient, it has stronger suction-operated, and often eating black fungus can play clearly
Reason alimentary canal, clearing stomach wash the effect of intestines.Vegetable soda contained by it is with the spy for promoting alimentary canal, the various glandular secretions of the urinary tract
Property, vegetable soda can cooperate with these secretion be catalyzed calculus, lubricate enteron aisle, excrete calculus.Black fungus also contains to human body
Beneficial plant colloid and one kind are called the substance of " polysaccharide body ", this is enriched in a kind of natural nourishing agent and black fungus
Cellulose collective effect, gastrointestinal peristalsis can be promoted and prevent constipation, be conducive in vivo defecate in poisonous and harmful substance it is clear in time
It removes and discharges.Black fungus also has the effect of anti peroxidation of lipid, makes people live longer.
Cumquat is sweet in flavor, warm-natured, energy regulating the flow of vital energy Xie Yu, resolving sputum.Cumquat prevents vascular sclerosis, high blood to safeguarding cardiovascular function
The diseases such as pressure have certain effect.Cumquat can enhance body cold tolerance, can prevent curing cold, reduce blood fat.Fruit contains rich
The ingredients such as rich vitamin C, cumquat glucoside, to safeguarding cardiovascular function, prevent the diseases such as vascular sclerosis, hypertension from having certain work
With.Kumquat contains the particular matters such as special volatile oil, kumquat glucoside, has the fragrance of pleasant, is the fruit for having much characteristic.
Containing relatively rich sugar in spirulina, there is bactericidal antiphlogistic, enhancing immunity of organisms, inhibit carcinogen carcinogenic
Effect.There is abundant cellulose in spirulina, have and promote intestines peristalsis, exclude the effect of vivotoxin.
Chlorophyll also has the function of antibacterial anti-inflammatory, meanwhile, the molecule of chlorophyll and the haemoglobin molecule of human body are being tied
It is very similar on structure, be exactly respectively uniquely respective core be magnesium atom and iron atom.Therefore, chlorophyll is to a certain extent
With hematopoiesis function, qi and blood is sufficient, could improve the immunity of human body.Furthermore chlorophyll has the function of to exclude vivotoxin.
Honey is sweet in flavor, mild-natured.Return lung, spleen, large intestine channel.With laxation defaecation, moisten the lung and relieve the cough, the effect of nourishing the middle-jiao, bee
Honey also has the function of antibacterial anti-inflammatory, promotes regeneration, promotes digestion.
Honeysuckle and Siraitia grosvenorii are mainly clearing heat and detoxicating, and bacterium, virus in pre- haze etc. enters people by respiratory tract
Body, this is first of outpost of the tax office;Black fungus contains abundant plant collagen ingredient, can absorb into the harmful substance of human body, spiral shell
A large amount of oligosaccharides in cellulose and honey abundant in algae is revolved, conducive to intestines peristalsis, the endotoxic discharge of acceleration bodies, this is second
The road outpost of the tax office;Ginseng temperature compensation QI invigorating, chlorophyll have certain hematopoiesis function, the situation of qi and blood abundance, and human body can just have relatively strong
Resistance, the raising of autoimmunity contributes to injury of the pre- haze for human body;This is fundamentally to improve human body certainly
The immunity of body, this is the third road outpost of the tax office;Needle mushroom and cumquat have the function of to accelerate human metabolism, that is to say, that certain
The immunity of the endotoxic discharge of acceleration bodies and promotion human body in degree, this is the 4th outpost of the tax office.Between each component mutually
Effect, from table and in, pre- haze is damaged caused by human body.
On the other hand, it since honeysuckle, Siraitia grosvenorii and needle mushroom are more cold and cool, is carried out by the ginseng with warm-heat effect
It adjusts, reduces the cold of this three, therefore so that the universality of this composition is strong.
Specific embodiment
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of composition of pre- haze harm, is counted in parts by weight, it include 10 parts of honeysuckle and Fructus Monordicae extract,
30 parts of 3 parts of ginseng extract, needle mushroom and black fungus extract, 10 parts of cumquat juice, 5 parts of spirulina powder, its molecule of spirulina powder
It measures as less than 1000,3 parts of chlorophyll, 3 parts of honey.
Wherein, the preparation method of honeysuckle and Fructus Monordicae extract is as follows:50 parts of extracting honeysuckle and arhat in parts by weight
40 parts of fruit, it is spare by moisture is filtered dry after honeysuckle and the cleaning of Siraitia grosvenorii flowing water;Siraitia grosvenorii is broken into pieces with one's fingers;Honeysuckle and Siraitia grosvenorii are used
The warm water constant temperature of 2 times of 40 DEG C of weight impregnates half an hour;It is heated to boiling after immersion, boil after twenty minutes, filtering takes filter residue to add in 1
The water of times honeysuckle and Siraitia grosvenorii original weight continues to be heated to boiling, after boiling 30 minutes, filtering, take twice filtrate merge it is subsequent
It is continuous to be heated to boiling, and be stirred continuously, it is spare that liquid extract is made.
Wherein, the preparation method of needle mushroom and black fungus extract is as follows:60 parts of needle mushroom and black wood are taken in parts by weight
50 parts of ear;Fresh needle mushroom is removed into root, cleans up that be filtered dry moisture spare;Black fungus is soaked, removes the root base of a fruit, cleaning is dry
Only it is spare to be filtered dry moisture;The needle mushroom handled well and black fungus are put into pulverizer to crush;By the needle mushroom after crushing and black wood
Ear adds in 50 DEG C of extraction 2h of pure water of 1 times of weight;Filtering, takes filtrate spare.
Wherein, the preparation method of cumquat juice is as follows:Cumquat is cleaned up and is filtered dry water, juice extractor is put into and squeezes cumquat
Juice;The 50 DEG C of extraction 1h of pure water of cumquat filter residue using 0.2 times of weight are taken, filtering takes filtrate to merge with former cumquat juice spare.
The present invention also improves the preparation method of the composition of pre- haze harm, and operating procedure is as follows:
(1) by 50 DEG C of 30 portions of needle mushrooms and black fungus extract filtrate constant temperature, 10 portions of honeysuckles and Siraitia grosvenorii extraction are added in
Logistics medicinal extract, stirring evenly is completely dissolved honeysuckle and Fructus Monordicae extract liquid extract, forms solution a;
(2) 3 parts of honey are added in solution a, are stirred evenly, form solution b;
(3) 3 parts of ginseng extracts are added in solution b, are stirred evenly, form solution c;
(4) 5 parts of spirulina powders are added in 10 parts of cumquat juice, are stirred evenly, form solution d;
(5) solution c with solution d is uniformly mixed, forms solution e;
(6) 3 parts of chlorophyll are added in solution e under dark conditions, obtain the composition of pre- haze harm.
Embodiment 2
A kind of composition of pre- haze harm, is counted in parts by weight, it include 15 parts of honeysuckle and Fructus Monordicae extract,
50 parts of 5 parts of ginseng extract, needle mushroom and black fungus extract, 15 parts of cumquat juice, 10 parts of spirulina powder, its molecule of spirulina powder
It measures as less than 1000,5 parts of chlorophyll, 5 parts of honey.
Wherein, the preparation method of honeysuckle and Fructus Monordicae extract is as follows:60 parts of extracting honeysuckle and arhat in parts by weight
50 parts of fruit, it is spare by moisture is filtered dry after honeysuckle and the cleaning of Siraitia grosvenorii flowing water;Siraitia grosvenorii is broken into pieces with one's fingers;Honeysuckle and Siraitia grosvenorii are used
The warm water constant temperature of 2 times of 60 DEG C of weight impregnates half an hour;It is heated to boiling after immersion, after boiling 30 minutes, filtering takes filter residue to add in 1
The water of times honeysuckle and Siraitia grosvenorii original weight continues to be heated to boiling, and boils after forty minutes, filtering, take twice filtrate merge it is subsequent
It is continuous to be heated to boiling, and be stirred continuously, it is spare that liquid extract is made.
Wherein, the preparation method of needle mushroom and black fungus extract is as follows:70 parts of needle mushroom and black wood are taken in parts by weight
60 parts of ear;Fresh needle mushroom is removed into root, cleans up that be filtered dry moisture spare;Black fungus is soaked, removes the root base of a fruit, cleaning is dry
Only it is spare to be filtered dry moisture;The needle mushroom handled well and black fungus are put into pulverizer to crush;By the needle mushroom after crushing and black wood
Ear adds in 70 DEG C of extraction 3h of pure water of 1 times of weight;Filtering, takes filtrate spare.
Wherein, the preparation method of cumquat juice is as follows:Cumquat is cleaned up and is filtered dry water, juice extractor is put into and squeezes cumquat
Juice;The 60 DEG C of extraction 2h of pure water of cumquat filter residue using 0.2 times of weight are taken, filtering takes filtrate to merge with former cumquat juice spare.
The present invention also improves the preparation method of the composition of pre- haze harm, and operating procedure is as follows:
(1) by 60 DEG C of 50 portions of needle mushrooms and black fungus extract filtrate constant temperature, 15 portions of honeysuckles and Siraitia grosvenorii extraction are added in
Logistics medicinal extract, stirring evenly is completely dissolved honeysuckle and Fructus Monordicae extract liquid extract, forms solution a;
(2) 5 parts of honey are added in solution a, are stirred evenly, form solution b;
(3) 5 parts of ginseng extracts are added in solution b, are stirred evenly, form solution c;
(4) 10 parts of spirulina powders are added in 15 parts of cumquat juice, are stirred evenly, form solution d;
(5) solution c with solution d is uniformly mixed, forms solution e;
(6) 5 parts of chlorophyll are added in solution e under dark conditions, obtain the composition of pre- haze harm.
Embodiment 3
A kind of composition of pre- haze harm, is counted in parts by weight, it include 12 parts of honeysuckle and Fructus Monordicae extract,
40 parts of 4 parts of ginseng extract, needle mushroom and black fungus extract, 12 parts of cumquat juice, 7 parts of spirulina powder, its molecule of spirulina powder
It measures as less than 1000,4 parts of chlorophyll, 4 parts of honey.
Wherein, the preparation method of honeysuckle and Fructus Monordicae extract is as follows:55 parts of extracting honeysuckle and arhat in parts by weight
45 parts of fruit, it is spare by moisture is filtered dry after honeysuckle and the cleaning of Siraitia grosvenorii flowing water;Siraitia grosvenorii is broken into pieces with one's fingers;Honeysuckle and Siraitia grosvenorii are used
The warm water constant temperature of 2 times of 50 DEG C of weight impregnates half an hour;It is heated to boiling after immersion, after boiling 25 minutes, filtering takes filter residue to add in 1
The water of times honeysuckle and Siraitia grosvenorii original weight continues to be heated to boiling, after boiling 35 minutes, filtering, take twice filtrate merge it is subsequent
It is continuous to be heated to boiling, and be stirred continuously, it is spare that liquid extract is made.
Wherein, the preparation method of needle mushroom and black fungus extract is as follows:65 parts of needle mushroom and black wood are taken in parts by weight
55 parts of ear;Fresh needle mushroom is removed into root, cleans up that be filtered dry moisture spare;Black fungus is soaked, removes the root base of a fruit, cleaning is dry
Only it is spare to be filtered dry moisture;The needle mushroom handled well and black fungus are put into pulverizer to crush;By the needle mushroom after crushing and black wood
Ear adds in 60 DEG C of extraction 2.5h of pure water of 1 times of weight;Filtering, takes filtrate spare.
Wherein, the preparation method of cumquat juice is as follows:Cumquat is cleaned up and is filtered dry water, juice extractor is put into and squeezes cumquat
Juice;The 55 DEG C of extraction 1.5h of pure water of cumquat filter residue using 0.2 times of weight are taken, filtering takes filtrate to merge with former cumquat juice spare.
The present invention also improves the preparation method of the composition of pre- haze harm, and operating procedure is as follows:
(1) by 55 DEG C of 40 portions of needle mushrooms and black fungus extract filtrate constant temperature, 12 portions of honeysuckles and Siraitia grosvenorii extraction are added in
Logistics medicinal extract, stirring evenly is completely dissolved honeysuckle and Fructus Monordicae extract liquid extract, forms solution a;
(2) 4 parts of honey are added in solution a, are stirred evenly, form solution b;
(3) 4 parts of ginseng extracts are added in solution b, are stirred evenly, form solution c;
(4) 7 parts of spirulina powders are added in 12 parts of cumquat juice, are stirred evenly, form solution d;
(5) solution c with solution d is uniformly mixed, forms solution e;
(6) 4 parts of chlorophyll are added in solution e under dark conditions, obtain the composition of pre- haze harm.
Embodiment 4
A kind of composition of pre- haze harm, is counted in parts by weight, it include 14 parts of honeysuckle and Fructus Monordicae extract,
45 parts of 45 parts of ginseng extract, needle mushroom and black fungus extract, 14 parts of cumquat juice, 8 parts of spirulina powder, its molecule of spirulina powder
It measures as less than 1000,5 parts of chlorophyll, 5 parts of honey.
Wherein, the preparation method of honeysuckle and Fructus Monordicae extract is as follows:55 parts of extracting honeysuckle and arhat in parts by weight
45 parts of fruit, it is spare by moisture is filtered dry after honeysuckle and the cleaning of Siraitia grosvenorii flowing water;Siraitia grosvenorii is broken into pieces with one's fingers;Honeysuckle and Siraitia grosvenorii are used
The warm water constant temperature of 2 times of 45 DEG C of weight impregnates half an hour;It is heated to boiling after immersion, after boiling 25 minutes, filtering takes filter residue to add in 1
The water of times honeysuckle and Siraitia grosvenorii original weight continues to be heated to boiling, after boiling 35 minutes, filtering, take twice filtrate merge it is subsequent
It is continuous to be heated to boiling, and be stirred continuously, it is spare that liquid extract is made.
Wherein, the preparation method of needle mushroom and black fungus extract is as follows:65 parts of needle mushroom and black wood are taken in parts by weight
55 parts of ear;Fresh needle mushroom is removed into root, cleans up that be filtered dry moisture spare;Black fungus is soaked, removes the root base of a fruit, cleaning is dry
Only it is spare to be filtered dry moisture;The needle mushroom handled well and black fungus are put into pulverizer to crush;By the needle mushroom after crushing and black wood
Ear adds in 65 DEG C of extraction 2-3h of pure water of 1 times of weight;Filtering, takes filtrate spare.
Wherein, the preparation method of cumquat juice is as follows:Cumquat is cleaned up and is filtered dry water, juice extractor is put into and squeezes cumquat
Juice;The 55 DEG C of extraction 2h of pure water of cumquat filter residue using 0.2 times of weight are taken, filtering takes filtrate to merge with former cumquat juice spare.
The present invention also improves the preparation method of the composition of pre- haze harm, and operating procedure is as follows:
(1) by 55 DEG C of 45 portions of needle mushrooms and black fungus extract filtrate constant temperature, 14 portions of honeysuckles and Siraitia grosvenorii extraction are added in
Logistics medicinal extract, stirring evenly is completely dissolved honeysuckle and Fructus Monordicae extract liquid extract, forms solution a;
(2) 5 parts of honey are added in solution a, are stirred evenly, form solution b;
(3) 5 parts of ginseng extracts are added in solution b, are stirred evenly, form solution c;
(4) 8 parts of spirulina powders are added in 14 parts of cumquat juice, are stirred evenly, form solution d;
(5) solution c with solution d is uniformly mixed, forms solution e;
(6) 5 parts of chlorophyll are added in solution e under dark conditions, obtain the composition of pre- haze harm.
Mouse experiment is carried out with composition made from the formula of embodiment 2 and method, healthy mice 60 is taken only to be randomly divided into
Five groups (regardless of male female):Blank group (feeding composition does not suck haze yet), negative control group (take in the pure of equal volume
Water), low dose group (5ml/d), middle dose group (10ml/d) and high dose group (15ml/d), every group of mouse 12.It will be negative right
It is passed through haze rear enclosed daily 10 hours according to group, low dose group, middle dosage combination high dose group.Haze is areal of traffic concentration haze
Its air collected, PM indexes are higher than 200.It is continuous to be passed through that haze air measures mouse weight after 30 days, lung weighs and calculates lung
Coefficient measures lung protective ventilation strategy (SP-A) content and lungs superoxide dismutase (SOD) activity and malonaldehyde
(MDA) content, each Testing index see the table below.
Comparison of 1 various dose of table to mouse paragonimus cyst
Group |
Number of animals |
Average paragonimus cyst (%) |
Blank group |
12 |
1.59 |
Negative control group |
12 |
2.18 |
5ml/d low dose groups |
12 |
2.03 |
10ml/d middle dose groups |
12 |
1.89 |
15ml/d high dose groups |
12 |
1.75 |
As it can be seen from table 1 causing certain damage for the lung of healthy mice after sucking haze, and pass through gavage sheet
After inventive composition, as the paragonimus cyst of the increase mouse of dosage is reduced, that is to say, that composition of the invention can be with
Alleviate damage of the haze to lung.
The variation of 2 mouse lung SP-A contents of table
Group |
Number of animals |
Average lung tissue SP-A contents (ng/L) |
Blank group |
12 |
90.17 |
Negative control group |
12 |
65.12 |
5ml/d low dose groups |
12 |
66.22 |
10ml/d middle dose groups |
12 |
72.39 |
15ml/d high dose groups |
12 |
81.88 |
From table 2 it can be seen that after sucking haze, the lung tissue SPA contents of healthy mice decline severity.Pass through this hair of gavage
After bright composition, with the increase of gavage amount, the lung tissue SPA contents of mouse are in rising trend.
SOD and MDA contents in 3 mouse lung tissue of table
From table 3 it can be seen that the SOD activity of mouse declines severe, MDA raising severities after sucking haze.Pass through gavage
After the present composition, with the increase of gavage amount, the SOD activity of mouse is in rising trend, and the MDA of mouse is on a declining curve.
Paragonimus cyst is one of index for reflecting lung injury, its paragonimus cyst is significantly raised after mouse sucks haze, this says
Bright, haze causes the lung of mouse certain damage.And it can be found that the lung surface of healthy mice is smooth from anatomic course
It is scarlet, and the lung of the mouse of haze its rough surface is sucked, and color is partially black, after the gavage present composition, mouse
Lung color tends to be scarlet with the increase of gavage amount.
It is above-mentioned it is demonstrated experimentally that composition of the invention can effectively pre- haze pulmonary lesion caused by mouse.
Human experimentation is carried out with composition made from the formula of embodiment 2 and method, haze is contacted with Qingdao City inner city
More crowd is experimental subjects, altogether 168 people, and between the age is 30-50 Sui, health, Ms is not pregnant not in lactation
Phase does not have the custom to wear masks in life.Experimental subjects is randomly divided into two groups, one group is experimental group, and 84 people take daily
The composition of the 40ml present invention;Another group is control group, does not take any product.Track record experimental subjects sucks haze daily
Time and the same day PM indexes and take the physical condition after the present composition, persistently track 3 months, be warm season
November to second year January.Wherein, have in experimental group in 2 people's experimentations and wear mask once in a while, there is 1 people not record in control group
Completely, it is invalid to be considered as.Count the result such as following table of effective sample.
1 experimental subjects of table takes the physical condition after the present composition
Wherein, flu rate is to add up total times of common cold divided by total number of persons.It can be obtained by above-mentioned human experimentation, the present invention
Composition can effectively pre- haze injured caused by human body.