CN104905405B - The cigarette of the essence containing plant flavone mouth stick preparation method and application - Google Patents
The cigarette of the essence containing plant flavone mouth stick preparation method and application Download PDFInfo
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- CN104905405B CN104905405B CN201510336905.0A CN201510336905A CN104905405B CN 104905405 B CN104905405 B CN 104905405B CN 201510336905 A CN201510336905 A CN 201510336905A CN 104905405 B CN104905405 B CN 104905405B
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- cigarette
- mouth stick
- containing plant
- plant flavone
- tow
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- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 57
- 229930003944 flavone Natural products 0.000 title claims abstract description 44
- 235000011949 flavones Nutrition 0.000 title claims abstract description 44
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title claims abstract description 38
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title claims abstract description 38
- 150000002212 flavone derivatives Chemical class 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 238000000605 extraction Methods 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000010992 reflux Methods 0.000 claims abstract description 13
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims abstract description 9
- XDQITMCFPPPMBC-TUANDBMESA-N scutelloside Natural products OC[C@H]1O[C@@H](O[C@@H]2O[C@@H]3C[C@H]4[C@H](O)[C@@H](O)[C@@](O)(CO3)[C@@H]24)[C@H](O)[C@@H](O)[C@@H]1O XDQITMCFPPPMBC-TUANDBMESA-N 0.000 claims abstract description 9
- 238000001914 filtration Methods 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims abstract description 3
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- 238000000034 method Methods 0.000 claims description 7
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- 238000001035 drying Methods 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 abstract description 39
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 abstract description 16
- 239000003546 flue gas Substances 0.000 abstract description 13
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract description 12
- 239000000126 substance Substances 0.000 abstract description 12
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 abstract description 8
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 abstract description 8
- 235000008777 kaempferol Nutrition 0.000 abstract description 8
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 abstract description 8
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- 235000009508 confectionery Nutrition 0.000 description 3
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- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
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- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 2
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- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
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- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/02—Manufacture of tobacco smoke filters
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
Abstract
The present invention discloses a kind of cigarette mouth stick preparation method and application of essence containing plant flavone, 1) weigh by weight percentage 20%~60% cyanidenon, 20%~60% scutelloside, 10%~30% Kaempferol, 10%~30% aurantiin, extracting solution is obtained by filtration as Extraction solvent refluxing extraction in ethanol solution after mixing;2) extracting solution is uniformly sprayed in tow;3) and then by the tow in step 2) dry;4) dried tow with forming paper and mouth stick tipping paper is wrapped up successively, the cigarette mouth stick of the essence containing plant flavone is made.The cigarette of the essence containing plant flavone is brought with mouth stick to cigarette comfortably smells fragrant sensation, and when cigarette is aspirated, these substances crack out the aroma component that can increase perfume quantity and aroma quality through burning;And active ingredient enters human oral cavity in cigarette with flue gas in the cigarette mouth stick of plant flavone essence, can directly act on throat, plays the role of good raising throat comfort.
Description
Technical field
The invention belongs to technical field of cigarettes, and in particular to a kind of cigarette of essence containing plant flavone with mouth stick preparation method and
Using.
Background technology
Natural plants are widely used in tobacco aromaticss, wherein being much containing Flavonoid substances.According to Flavonoid substances
Molecular characterization and interelectric active force power, Primary Study find such substance burning crack after can generate
Furans and its derivative, these substances are the main aroma components in flue gas, can be brought camerlsed to flue gas, it is fragrant and sweet,
Roasting perfume, increases perfume quantity and aroma quality.Therefore in the allotment of essence spice for cigarette, there is the use of many flavonoids perfume materials.
Many researchs also indicate that, flavone compound has multiple biological activities, except using its antibacterial, anti-inflammatory, anti-mutation,
Outside the effects that decompression, clearing heat and detoxicating, calm, diuresis, in anti-oxidant, anticancer, anti-cancer, inhibit lipase etc. and also have notable effect
Fruit.It is the scavenger of most of oxygen radicals, thus the vigor of energy increased SOD (superoxide dismutase), reduces MDA (fat
Matter peroxide malonaldehyde) and OX-LDL (OxLDL ELISA) generation.It can increase coronary flow, to experiment
Myocardial inyaretion has antagonism;There is protective effect to acute myocardial ischemia;Have to treatment coronary heart diseases and angina pectoris, hypertension etc.
Remarkable result;To reducing diastolic pressure, prevention arrhythmia cordis, cardiovascular disease and promoting blood circulation and removing blood stasis also play an important role.
The smog that substantial amounts of scientific research is demonstrated from different angles in tobacco is chronic respiratory disease, coronary heart disease
Etc. the pathogenetic important risk factor of a variety of diseases.Long-term smoker generally has cough, abundant expectoration, the symptom of throat itch, seriously
Influence health and the quality of life of the mankind.In addition, passive smoking also results in harm to the health of women.In order to mitigate tobacco
Harm of the middle smog to human body, in positive publicity, Smoking is harmful to your health and while advice smoking cessation, also should active development have
The harm reduction cigarette of the effects that easypro larynx.
Throat is the important component of respiratory tract, positioned at the important of the confluce and human body pronunciation of tracheae and esophagus
Organ.When smoker is in smoking, be most vulnerable to harmful substances from flue gases influence is exactly throat.Tar easily retains in flue gas
In the internal of smoking people, a kind of emplastic is condensed into lung, is attached to the trachea-bronchial epithelial cell and alveolar surface of smoker,
Physics, chemical stimulation are generated, influences the breathing of human body;The defense function of bottleneck throat mucous membrane can be reduced by smoking for a long time, it may appear that
Dry cough, throat's shouting pain bring sense of discomfort when sensations or when smoking causes irascibility excessively prosperous to throat;It is exhaled so smoking for human body
Road is inhaled, the harm of particularly throat is larger, is with the passing of time likely to result in laryngeal pathological process.
A large amount of correlative studys find the organ that respiratory tract is stimulated as direct body contact's ambient atmos, are that tobacco damages
The person of being primarily subjected to.And airway epithelial cell resists the first line of defence of environmental stimuli as respiratory tract, suffered harm is particularly tight
Weight.Previously alveolar epithelium and bronchiolar epithelium plasma urokinase-type plasminogen activator can be adjusted researches show that cigarette stimulates
(Urokinase type plasminogen activator, uPA), uPAR Research
(urokinase type plasminogen activator receptor, uPAR) system expression changes, alveolar epithelial cells
The horizontal up-regulations of uPA and uPAR are more notable, uPA advantage states are presented, beneficial to proteolysis.Urine is then presented in bronchial epithelial cell
Kinases type Plasminogen Activator Inhibitor-1 (plasminogen activator inhibitor-1, PAI-1) advantage shape
State is conducive to fibrosis and is formed.Two kinds of cells are possible to uPA system expressions state difference can be with partial interpretation COPD patient lung qi
The reason for swollen and small airway fibrosis both different pathologicals variation.It is another to have the section of document report lung tissue of rats and smoke from cigarette
Extract is incubated jointly, can increase lung tissue of rats lactic dehydrogenase (lactatec dehydrogenate, LDH) leak out and
Nitrite NO2- discharges, and stimulates nitric oxide synthase type (induced nitric oxide synthase, iNOS) living
Property increase, cause injury of lungs.It can be seen that long-term fume exposure can trigger airway epithelial cell form and function damage, from
And the normal physiological function of upper lower respiratory tract is influenced, smoker is made to generate uncomfortable sensation or even seriously affect life quality
(quality of life, QOF) and life security.From consumer's interests are safeguarded, the road of reducing tar and reducing harm is walked, is Chinese style volume
The developing direction of cigarette.On the premise of consumer's physiology, psychological needs are met, its unfavorable shadow brought to consumer throat is reduced
It rings, promotes throat's comfort, be tobacco business scientific research personnel's urgent problem to be solved.
Throat's comfort well refer to consumer when product inhale cigarette the smooth exquisiteness of the flue gas experienced, oral cavity noresidue,
Nose larynx is non-stimulated, aftertaste has the impressions such as sweet tea sense.Laryngeal response is concentrated mainly on oral cavity and respiratory system during the smoking process
The impression at position is embodied in drop thorn, resolving sputum, the improvement promoted the production of body fluid etc., can preferably realize suction comfort.
Drop thorn:Irritation refers to impact of the flue gas to sense organ.It is divided into oral stimulation in impression, nasal cavity stimulates and throat's thorn
Swash three kinds.Irritation is big, seemingly there is " peppery " taste in oral cavity, can draw tears from sb or shed tears sense in nasal cavity, can make throat in throat
Deflation causes cough.
The irritation of flue gas is mainly excessive by acid excessive in cigarette and alkalescence and generates, at the same with the water of cigarette
Point, tightness etc. it is also related.Peppery thorn is since alkaline matter is on the high side;Thorn of choking is since small molecule shot-like particle is on the high side;Spine (hair
Thorn) it is since acidic materials are on the high side.
Flavone compound plays an important role of diastole bronchial smooth muscle, adds in cigarette, can weaken the contracting of flue gas
Pipe acts on, and it is uncomfortable caused by throat to alleviate smoke-shock.
Resolving sputum:The people of long-term smoker generally has a degree of pharyngitis, and performance is abundant expectoration and frequency.Having in flue gas
Evil substance is frequently gathered in respiratory tract, caused by accelerating the wriggling of villus fiber.
Flavone compound can reduce flue gas life phlegm substance, certainly will can reduce heap of the constituents in respiratory system
Product.In addition, flavone compound can speed up tracheae villus fiber wriggling, harmful substance is made quickly to be excluded with juice external,
This resolving sputum effect just played to a certain extent.
It promotes the production of body fluid:Tianjin is saliva, and it is exactly to make to secret out of saliva in oral cavity to promote the production of body fluid.Modern medicine is it also holds that containing more in saliva
Helpful body composition is planted, promoting the production of body fluid in mouth, it is easypro suitable to quench one's thirst.
The effect of a variety of flavone compounds have nourishing Yin and promoting production of body fluid, and moistening lung is relieved inflammation or internal heat, Heat Diabetes.Addition, can in cigarette
Oral cavity taste bud is stimulated with effect of promoting the production of body fluid, flue gas is more mellow and fuller, with sweet tea sense is returned, reduces withered sense.
Much contain Flavonoid substances in tobacco aromaticss, but for specifically for improve throat's comfort, have cough-relieving,
Resolving sputum, the composition of effect of relievining asthma are had not been reported, it is necessary to for further study.
The content of the invention
In view of the deficiencies of the prior art, the present invention provide it is a kind of have effects that cough-relieving, resolving sputum, relieving asthma containing plant flavone perfume
The cigarette mouth stick preparation method and application of essence, plant flavone essence is added in the tow of mouth stick, during the smoking process,
Its excellent anti-inflammatory, sharp larynx effect is played, so as to improve throat's comfort of cigarette smoking, improves cigarette smoking quality.
Technical solution is used by the present invention solves above-mentioned technical problem:The cigarette for providing a kind of essence containing plant flavone is used
Mouth stick preparation method, includes the following steps:
1) weigh by weight percentage 20%~60% cyanidenon, 20%~60% scutelloside, 10%~30%
Kaempferol, 10%~30% aurantiin, extraction is obtained by filtration as Extraction solvent refluxing extraction in ethanol solution after mixing
Liquid;
2) extracting solution is uniformly sprayed in tow;
3) and then by the tow in step 2) dry;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Further, the mass percentage concentration of the ethanol solution is 70%~90%.
Further, when refluxing extraction 2~4 times in the step 1), each refluxing extraction 2~4 are small.
Further, the drying temperature in the step 3) is 25 DEG C~40 DEG C.
A kind of cigarette, including cigarette mouth stick and pipe tobacco, the cigarette mouth stick prepares yellow containing plant for method described above
The cigarette of ketone essence mouth stick.
The present invention has the following advantages:
1st, the cigarette of the essence of the invention containing plant flavone has excellent natural breath with mouth stick, brings to cigarette and comfortably smells
Perfume is felt, when cigarette is aspirated, these substances crack out the aroma component that can increase perfume quantity and aroma quality through burning, further
Improve cigarette smoking quality;
2nd, active ingredient enters human oral cavity in cigarette with flue gas in the cigarette mouth stick of the essence of the invention containing plant flavone,
Throat can be directly acted on, plays the role of good raising throat comfort;
3rd, plant flavone flavor of raw material of the present invention derives from a wealth of sources, of low cost, easy to utilize.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.The specific embodiments described herein are merely illustrative of the present invention, is not used to limit this hair
It is bright.
Embodiment 1
1) plant flavone essence according to ratio in table 1 is mixed, is dissolved in the ethanol solution that mass percentage concentration is 70%,
Refluxing extraction 2 times when extraction 3 is small every time, filters, is mixed to get extracting solution;
2) extracting solution in step 1) is uniformly sprayed in tow;
3) it is and then the tow in step 2) is dry at 25 DEG C;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Table 1
Flavones species | Cyanidenon | Scutelloside | Kaempferol | Aurantiin |
Weight percent | 30% | 20% | 30% | 20% |
Embodiment 2
1) plant flavone essence according to ratio in table 1 is mixed, is dissolved in the ethanol solution that mass percentage concentration is 70%,
Refluxing extraction 2 times when extraction 4 is small every time, filters, is mixed to get extracting solution;
2) extracting solution in step 1) is uniformly sprayed in tow;
3) it is and then the tow in step 2) is dry at 35 DEG C;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Table 2
Flavones species | Cyanidenon | Scutelloside | Kaempferol | Aurantiin |
Weight percent | 30% | 30% | 20% | 20% |
Embodiment 3
1) plant flavone essence according to ratio in table 1 is mixed, is dissolved in the ethanol solution that mass percentage concentration is 80%,
Refluxing extraction 4 times when extraction 2 is small every time, filters, is mixed to get extracting solution;
2) extracting solution in step 1) is uniformly sprayed in tow;
3) it is and then the tow in step 2) is dry at 35 DEG C;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Table 3
Flavones species | Cyanidenon | Scutelloside | Kaempferol | Aurantiin |
Weight percent | 40% | 30% | 15% | 15% |
Embodiment 4
1) plant flavone essence according to ratio in table 1 is mixed, is dissolved in the ethanol solution that mass percentage concentration is 80%,
Refluxing extraction 2 times when extraction 4 is small every time, filters, is mixed to get extracting solution;
2) extracting solution in step 1) is uniformly sprayed in tow;
3) it is and then the tow in step 2) is dry at 35 DEG C;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Table 4
Flavones species | Cyanidenon | Scutelloside | Kaempferol | Aurantiin |
Weight percent | 40% | 40% | 10% | 10% |
Embodiment 5
1) plant flavone essence according to ratio in table 1 is mixed, is dissolved in the ethanol solution that mass percentage concentration is 90%,
Refluxing extraction 2 times when extraction 2 is small every time, filters, is mixed to get extracting solution;
2) extracting solution in step 1) is uniformly sprayed in tow;
3) it is and then the tow in step 2) is dry at 40 DEG C;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Table 5
Flavones species | Cyanidenon | Scutelloside | Kaempferol | Aurantiin |
Weight percent | 20% | 20% | 30% | 30% |
Embodiment 6
1) plant flavone essence according to ratio in table 1 is mixed, is dissolved in the ethanol solution that mass percentage concentration is 90%,
Refluxing extraction 4 times when extraction 2 is small every time, filters, is mixed to get extracting solution;
2) extracting solution in step 1) is uniformly sprayed in tow;
3) it is and then the tow in step 2) is dry at 40 DEG C;
4) dried tow is wrapped up successively with forming paper and mouth stick tipping paper, the cigarette that the essence containing plant flavone is made is used
Mouth stick.
Table 6
Flavones species | Cyanidenon | Scutelloside | Kaempferol | Aurantiin |
Weight percent | 25% | 25% | 25% | 25% |
For caused by smoking " cough, abundant expectoration are panted " three big symptoms, in the classical respiratory tract antibechic of reference, eliminating the phlegm, relieving asthma
Pharmacodynamic evaluation method on the basis of, from a variety of different biological models screening establish exhaled suitable for natural plant extracts
The method of pipe protection effect assessment is inhaled, eliminating the phlegm is evaluated using ammonia induced cough in mice evaluation antitussive effect, the phenol red excretion method of mouse
Effect, Guinea pig isolated trachea spiral strip method evaluation antiasthmatic effect.
The cigarette mouth stick of the prepared essence containing plant flavone in above 6 embodiments with pipe tobacco is engaged and makes cigarette, it is right
Cigarette carries out detection of exhaust gas compositions, and carries out phenol reduced rate and compare, and is specifically shown in the following table 7
Table 7
*P<0.05,**P<0.01 compared with equal number blank cigarette group
The cigarette mouth stick of the prepared essence containing plant flavone in embodiment in above 6 embodiments with pipe tobacco is engaged and is made
Cigarette carries out cigarette carry out sensory evaluation, as a result such as table 8
Table 8
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any
Belong to those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in all should
It is included within the scope of the present invention.Therefore, protection scope of the present invention should be subject to the protection scope in claims.
Claims (4)
1. a kind of cigarette of essence containing plant flavone mouth stick preparation method, it is characterised in that:The preparation method includes following step
Suddenly:
1) 20%~40% cyanidenon, 20%~40% scutelloside, 10%~30% mountain is weighed by weight percentage
How phenol, 10%~30% aurantiin, extracting solution is obtained by filtration as Extraction solvent refluxing extraction in ethanol solution after mixing;Institute
The mass percentage concentration for stating ethanol solution is 70%~90%;
2) extracting solution is uniformly sprayed in tow;
3) and then by the tow in step 2) dry;
4) dried tow with forming paper and mouth stick tipping paper is wrapped up successively, the cigarette mouth of the essence containing plant flavone is made
Stick.
2. the cigarette of the essence according to claim 1 containing plant flavone mouth stick preparation method, it is characterised in that:The step
1) when refluxing extraction 2~4 times in, each refluxing extraction 2~4 are small.
3. the cigarette of the essence according to claim 1 containing plant flavone mouth stick preparation method, it is characterised in that:The step
3) drying temperature in is 25 DEG C~40 DEG C.
4. a kind of cigarette, including cigarette mouth stick and pipe tobacco, it is characterised in that:The cigarette is claims 1 to 3 any one with mouth stick
The cigarette mouth stick of the essence containing plant flavone prepared by item the method.
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CN106617262B (en) * | 2016-12-14 | 2017-11-07 | 湖北中烟工业有限责任公司 | One grows tobacco buccal tablet and preparation method thereof |
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CN109330016A (en) * | 2018-11-14 | 2019-02-15 | 河南中烟工业有限责任公司 | A kind of Exocarpium Citri Grandis medicinal extract, preparation method and the application in cigarette |
CN110693079A (en) * | 2019-09-05 | 2020-01-17 | 云南农业大学 | Pure natural cigarette smoke adsorbent and use method thereof |
CN111990689A (en) * | 2020-08-20 | 2020-11-27 | 广西中烟工业有限责任公司 | Preparation method of chestnut shell pigment cigarette filter stick |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0638727A (en) * | 1991-07-25 | 1994-02-15 | Tsugio Yamamoto | Filter for tobacco |
WO2003053179A1 (en) * | 2001-12-21 | 2003-07-03 | Filtrona Italia S.P.A. | Cigarette filters containing lipophile flavonoids and/or tocopherols and tocotrienols |
CN1488300A (en) * | 2003-08-19 | 2004-04-14 | 广东神农烟科技术有限公司 | Cigarette additive extracted from natural plant, and extracting method and use in cigarette thereof |
CN1781388A (en) * | 2004-12-03 | 2006-06-07 | 李忠 | Wild chrysanthemam flower low harm cigarette capable of reducing cigarette harm |
CN102090712A (en) * | 2010-12-29 | 2011-06-15 | 华宝食用香精香料(上海)有限公司 | Method for preparing coarse extract of peanut shell total flavones and application thereof in cigarettes |
CN104068467A (en) * | 2014-07-01 | 2014-10-01 | 安徽中烟工业有限责任公司 | Electronic cigarette liquid rich in plant flavone |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080053470A1 (en) * | 2006-09-01 | 2008-03-06 | Wu-Ming Tzung | Environmentally friendly cigarette replacement |
-
2015
- 2015-06-17 CN CN201510336905.0A patent/CN104905405B/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0638727A (en) * | 1991-07-25 | 1994-02-15 | Tsugio Yamamoto | Filter for tobacco |
WO2003053179A1 (en) * | 2001-12-21 | 2003-07-03 | Filtrona Italia S.P.A. | Cigarette filters containing lipophile flavonoids and/or tocopherols and tocotrienols |
CN1488300A (en) * | 2003-08-19 | 2004-04-14 | 广东神农烟科技术有限公司 | Cigarette additive extracted from natural plant, and extracting method and use in cigarette thereof |
CN1781388A (en) * | 2004-12-03 | 2006-06-07 | 李忠 | Wild chrysanthemam flower low harm cigarette capable of reducing cigarette harm |
CN102090712A (en) * | 2010-12-29 | 2011-06-15 | 华宝食用香精香料(上海)有限公司 | Method for preparing coarse extract of peanut shell total flavones and application thereof in cigarettes |
CN104068467A (en) * | 2014-07-01 | 2014-10-01 | 安徽中烟工业有限责任公司 | Electronic cigarette liquid rich in plant flavone |
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