CN105167177B - Cigarette flavones essence cigarette pearl, preparation method and application - Google Patents
Cigarette flavones essence cigarette pearl, preparation method and application Download PDFInfo
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- CN105167177B CN105167177B CN201510337686.8A CN201510337686A CN105167177B CN 105167177 B CN105167177 B CN 105167177B CN 201510337686 A CN201510337686 A CN 201510337686A CN 105167177 B CN105167177 B CN 105167177B
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- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 88
- 229930003944 flavone Natural products 0.000 title claims abstract description 78
- 235000011949 flavones Nutrition 0.000 title claims abstract description 78
- 150000002213 flavones Chemical class 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000000853 adhesive Substances 0.000 claims abstract description 12
- 230000001070 adhesive effect Effects 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims abstract description 9
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 claims abstract description 9
- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 claims abstract description 9
- AIONOLUJZLIMTK-UHFFFAOYSA-N hesperetin Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-UHFFFAOYSA-N 0.000 claims abstract description 9
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- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 claims abstract description 9
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- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 abstract description 16
- 239000003546 flue gas Substances 0.000 abstract description 13
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract description 12
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- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 abstract description 8
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention discloses a kind of cigarette flavones essence cigarette pearl, preparation method and application, weigh the adhesive that weight is flavones essence weight 0.1%~1%, it is added to after adhesive water dissolves in flavones essence, first pass through extruder and be extruded into elongated strip, then it is round as a ball by spheronizator, obtain flavones essence cigarette pearl after drying；The weight percentages of components of the flavones essence includes Puerarin 10%~40%, Quercetin 10%~40%, catechol 20%~50%, hesperetin 20%~50%.Flavones essence cigarette pearl of the invention has excellent natural breath, is brought to cigarette and comfortably smell fragrant sensation, and when cigarette is aspirated, these materials crack out the aroma component that can increase perfume quantity and aroma quality through burning；The active component of flavones essence cigarette pearl of the invention enters human oral cavity in cigarette with flue gas, can directly act on throat, plays a part of good raising throat comfortableness.
Description
Technical field
The invention belongs to technical field of cigarettes, and in particular to a kind of cigarette flavones essence cigarette pearl, preparation method and application.
Background technology
Natural plants are widely used in tobacco aromaticss, wherein being much to contain Flavonoid substances.According to Flavonoid substances
Molecular characterization and interelectric active force power, Primary Study find such material burn cracking after can produce
Furans and its derivative, these materials are the main aroma components in flue gas, can to flue gas bring camerlsed, it is fragrant and sweet,
Roasting perfume, increases perfume quantity and aroma quality.Therefore in the allotment of essence spice for cigarette, there is the use of many flavonoids perfume materials.
Many researchs also indicate that flavone compound has multiple biological activities, except using its antibacterial, anti-inflammatory, anti-mutation,
The effect such as step-down, clearing heat and detoxicating, calm, diuresis is outer, also has significantly effect at aspects such as anti-oxidant, anticancer, anti-cancer, suppression lipase
Really.It is the scavenger of most of oxygen radicals, thus can increased SOD (superoxide dismutase) vigor, reduce MDA (fat
Matter peroxide MDA) and OX-LDL (OxLDL ELISA) generation.It can increase coronary flow, to experiment
Myocardial inyaretion has antagonism；There is protective effect to acute myocardial ischemia；Have to treatment coronary heart diseases and angina pectoris, hypertension etc.
Remarkable result；To reducing diastolic pressure, prevent and treat arrhythmia cordis, cardiovascular disease and promoting blood circulation and removing blood stasis also play an important role.
The smog that substantial amounts of scientific research demonstrates in tobacco from different angles is chronic respiratory disease, coronary heart disease
Etc. the pathogenetic important risk factor of various diseases.Long-term smoker typically has the symptom of cough, abundant expectoration, throat itch, seriously
Influence health and the quality of life of the mankind.Additionally, passive smoking also results in harm to the health of women.In order to mitigate tobacco
Harm of the middle smog to human body, actively publicity Smoking is harmful to your health and advice smoking cessation while, also should active development have
The harm reduction cigarette of the effects such as easypro larynx.
Throat is the important component of respiratory tract, is also the important of human body pronunciation positioned at tracheae and the confluce of esophagus
Organ.When smoker is in smoking, be most vulnerable to harmful substances from flue gases influence is exactly throat.Tar is easily retained in flue gas
In the internal of smoking people, a kind of emplastic is condensed into lung, is attached to the trachea-bronchial epithelial cell and alveolar surface of smoker,
Physics, chemical stimulation are produced, the breathing of human body is influenceed；Smoking for a long time can reduce the defense function of bottleneck throat mucous membrane, it may appear that
Dry cough, throat's shouting pain etc. are felt, or bring sense of discomfort to throat because smoking causes irascibility excessively prosperous；So smoking is exhaled for human body
The harm for inhaling road, particularly throat is larger, is with the passing of time likely to result in laryngeal pathological process.
A large amount of correlative studys find the organ that respiratory tract stimulates as direct body contact's ambient atmos, are tobacco infringements
The person of being primarily subjected to.And airway epithelial cell resists the first line of defence of environmental stimuli as respiratory tract, suffered harm is particularly tight
Weight.Previously research display cigarette stimulates can adjust alveolar epithelium and bronchiolar epithelium plasma urokinase-type plasminogen activator
(Urokinase type plasminogen activator, uPA), uPAR Research
(urokinase type plasminogen activator receptor, uPAR) system expression changes, alveolar epithelial cells
UPA and uPAR levels raise more notable, presentation uPA advantage states, beneficial to proteolysis.Bronchial epithelial cell is then presented urine
Kinases type PAI-1 (plasminogen activator inhibitor-1, PAI-1) advantage shape
State, is conducive to fibrosis to be formed.Two kinds of cells are possible to uPA system expressions state difference can be with partial interpretation COPD patient lung qi
The reason for swollen and small airway fibrosis both different pathologicals change.It is another to there is document report lung tissue of rats to cut into slices and smoke from cigarette
Extract is incubated jointly, can increase lung tissue of rats lactic dehydrogenase (lactatec dehydrogenate, LDH) spill and
Nitrite NO2- discharges, and stimulates nitric oxide synthase type (induced nitric oxide synthase, iNOS) living
Property increase, cause injury of lungs.As can be seen here, long-term fume exposure can trigger airway epithelial cell form and function damage, from
And the normal physiological function of the upper lower respiratory tract of influence, smoker is produced uncomfortable sensation, or even have a strong impact on life quality
(quality of life, QOF) and life security.From consumer's interests are safeguarded, the road of reducing tar and reducing harm is walked, be Chinese style volume
The developing direction of cigarette.On the premise of consumer's physiology, psychological needs are met, its unfavorable shadow brought to consumer throat is reduced
Ring, lifting throat comfortableness, is tobacco business scientific research personnel's problem demanding prompt solution.
The smooth exquisiteness of flue gas that throat's comfortableness refers to well consumer to be experienced when product inhale cigarette, oral cavity noresidue,
Nose larynx is non-stimulated, aftertaste has the impressions such as sweet sense.Laryngeal response is concentrated mainly on oral cavity and respiratory system during cigarette smoking
The impression at position, is embodied in drop thorn, resolving sputum, the improvement of the aspect such as promote the production of body fluid, and can preferably realize suction comfortableness.
Drop thorn：Excitant refers to impact of the flue gas to sense organ.Being divided into oral stimulation, nasal cavity in impression stimulates and throat's thorn
Swash three kinds.Excitant is big, seemingly has " peppery " taste in oral cavity, can be drawn tears from sb or shed tears sense in nasal cavity, and throat can be made in throat
Deflation causes cough.
The excitant of flue gas is mainly what is produced by acid excessive and alkaline excessive in cigarette, while the water with cigarette
Point, tightness etc. it is also relevant.Peppery thorn is because alkaline matter is on the high side；Thorn of choking is because small molecule shot-like particle is on the high side；Spine (hair
Thorn) it is because acidic materials are on the high side.
Flavone compound has the effect of diastole bronchial smooth muscle, adds in cigarette, can weaken the contracting of flue gas
Pipe is acted on, and alleviates the discomfort that smoke-shock is caused to throat.
Resolving sputum：The people of long-term smoker typically has a certain degree of pharyngitis, and its performance is abundant expectoration and frequency.Having in flue gas
Evil material is frequently gathered in respiratory tract, caused by accelerating the wriggling of villus fiber.
Flavone compound can reduce flue gas life phlegm material, certainly will can reduce heap of the constituents in respiratory system
Product.In addition, flavone compound can speed up tracheae villus fiber wriggling, make harmful substance quick and excluded in vitro with juice,
Resolving sputum effect that this is just served to a certain extent.
Promote the production of body fluid：Tianjin is saliva, and it is exactly to make to secret out of saliva in oral cavity to promote the production of body fluid.Modern medicine is it also holds that containing many in saliva
Helpful body composition is planted, being promoted the production of body fluid in mouth, it is easypro suitable to quench one's thirst.
Various flavone compounds have nourishing Yin and promoting production of body fluid, and moistening lung is relieved inflammation or internal heat, effect of Heat Diabetes.Addition, can in cigarette
Stimulate oral cavity taste bud and there is effect of promoting the production of body fluid, flue gas is more mellow and fuller, with sweet sense is returned, reduces withered sense.
It is many in tobacco aromaticss to contain Flavonoid substances, but for specifically designed for improve throat's comfortableness, with cough-relieving,
Resolving sputum, the composition of effect of relievining asthma are had not been reported, it is necessary to for further study.
The cigarette pearl containing essence and flavoring agent is put into filter tip in the prior art, the cigarette pearl can make cigarette in aspiration procedure
In it is more raw fragrant, strengthen fragrance or characteristic, smoker is obtained more comfortable experience.This cigarette pearl can only simply make cigarette
It is raw fragrant in aspiration procedure, it is impossible to play cough-relieving, resolving sputum, effect of relievining asthma.
The content of the invention
In view of the shortcomings of the prior art, the present invention provides a kind of cigarette flavones perfume with cough-relieving, resolving sputum, effect of relievining asthma
Smart cigarette pearl, preparation method and application, cigarette flavones essence cigarette pearl is added in pipe tobacco, during cigarette smoking, plays its excellent
Different anti-inflammatory, sharp larynx effect, so as to improve throat's comfortableness of cigarette smoking, improves cigarette smoking quality.
The present invention solves the technical scheme that is used of above-mentioned technical problem：A kind of system of cigarette flavones essence cigarette pearl is provided
Preparation Method, the preparation method is as follows：
The adhesive that weight is flavones essence weight 0.1%~1% is weighed, flavones is added to after adhesive water dissolves fragrant
In essence, stir and be made softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, so
It is round as a ball by spheronizator afterwards, particle size range is obtained after drying for 0.5mm~4mm, heap density are the Huang of 1.2g/ml~1.8g/ml
Ketone essence cigarette pearl；
Wherein：The weight percentages of components of the flavones essence is as follows：
Further, the DNA purity of the Puerarin, Quercetin, catechol and hesperetin is 80~95%.
Further, described adhesive is PVP, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and carboxymethyl cellulose
One or more in element.
Further, the particle size range of the cigarette pearl is 0.8mm~1.5mm, and heap density is 1.4g/ml~1.6g/ml.
Further, the drying is dried 4~6 hours under the conditions of temperature is for 60 DEG C~80 DEG C.
A kind of cigarette is flavones essence cigarette prepared by method described above with flavones essence cigarette pearl, the flavones essence cigarette pearl
Pearl.
A kind of cigarette application of flavones essence cigarette pearl, by flavones essence cigarette pearl by weight percentage 0.1~5.0：100 add
Cigarette is made in pipe tobacco, the flavones essence cigarette pearl is flavones essence cigarette pearl prepared by method described above.
The present invention has advantages below：
1st, flavones essence cigarette pearl of the invention has excellent natural breath, is brought to cigarette and comfortably smell fragrant sensation, cigarette
When branch is aspirated, these materials crack out the aroma component that can increase perfume quantity and aroma quality through burning, further improve volume
Cigarette suction quality；
2nd, the active component of flavones essence cigarette pearl of the invention enters human oral cavity in cigarette with flue gas, can directly make
For throat, play a part of good raising throat comfortableness；
3rd, flavones essence cigarette pearl of the present invention is added in pipe tobacco, and any production process is not increased, simple and easy to apply, favorably
In industrial-scale production；
4th, flavones flavor of raw material wide material sources of the present invention, with low cost, easy to utilize.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.The specific embodiments described herein are merely illustrative of the present invention, is not used to limit this hair
It is bright.
Embodiment 1
Flavones essence is mixed according to ratio in table 1, the hydroxypropyl methyl that weight is flavones essence weight 0.1% is weighed fine
The plain adhesive of dimension, with being added in flavones essence after 400ml water dissolves, stirs and is made softwood, then will be squeezed on softwood
Go out-spheronizator, first pass through extruder and be extruded into elongated strip, then round as a ball by spheronizator, upper fluid bed is 60 DEG C in temperature
Under the conditions of dry 6 hours after obtain particle diameter for 0.5mm, heap density for 1.8g/ml flavones essence cigarette pearl.
Table 1
| Flavones species | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 15% | 15% | 30% | 40% |
Embodiment 2
Flavones essence is mixed according to ratio in table 2, the hydroxypropyl methyl that weight is flavones essence weight 0.5% is weighed fine
The plain adhesive of dimension, with being added in flavones essence after 450ml water dissolves, stirs and is made softwood, then will be squeezed on softwood
Go out-spheronizator, first pass through extruder and be extruded into elongated strip, then round as a ball by spheronizator, upper fluid bed is 65 DEG C in temperature
Under the conditions of dry 5.5 hours after obtain particle diameter for 0.8mm, heap density for 1.6g/ml flavones essence cigarette pearl.
Table 2
| Flavones species | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 20% | 20% | 20% | 40% |
Embodiment 3
Flavones essence is mixed according to ratio in table 3, the carboxymethylcellulose calcium that weight is flavones essence weight 0.8% is weighed
Adhesive, with being added in flavones essence after 500ml water dissolves, stirs and is made softwood, then by extrusion-rolling on softwood
Circular knitting machine, first passes through extruder and is extruded into elongated strip, then round as a ball by spheronizator, under the conditions of upper fluid bed is 70 DEG C in temperature
Particle diameter is obtained after drying 6 hours for 1.0mm, heap density are the flavones essence cigarette pearl of 1.6g/ml.
Table 3
| Flavones species | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 30% | 30% | 20% | 20% |
Embodiment 4
Flavones essence is mixed according to ratio in table 4, the carboxymethylcellulose calcium that weight is flavones essence weight 0.8% is weighed
Adhesive, with being added in flavones essence after 500ml water dissolves, stirs and is made softwood, then by extrusion-rolling on softwood
Circular knitting machine, first passes through extruder and is extruded into elongated strip, then round as a ball by spheronizator, under the conditions of upper fluid bed is 75 DEG C in temperature
Particle diameter is obtained after drying 6 hours for 1.5mm, heap density are the flavones essence cigarette pearl of 1.4g/ml.
Table 4
| Flavones species | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 10% | 30% | 40% | 20% |
Embodiment 5
Flavones essence is mixed according to ratio in table 5, the hydroxypropyl cellulose that weight is flavones essence weight 1% is weighed and is glued
Mixture, with being added in flavones essence after 550ml water dissolves, stirs and is made softwood, then will be extruded on softwood-round as a ball
Machine, first passes through extruder and is extruded into elongated strip, then round as a ball by spheronizator, and upper fluid bed is done under the conditions of being 70 DEG C in temperature
Particle diameter is obtained after dry 5 hours for 1.5mm, heap density are the flavones essence cigarette pearl of 1.4g/ml.
Table 5
| Flavones species | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 10% | 40% | 20% | 30% |
Embodiment 6
Flavones essence is mixed according to ratio in table 6, the hydroxypropyl cellulose that weight is flavones essence weight 1% is weighed and is glued
Mixture, with being added in flavones essence after 550ml water dissolves, stirs and is made softwood, then will be extruded on softwood-round as a ball
Machine, first passes through extruder and is extruded into elongated strip, then round as a ball by spheronizator, and upper fluid bed is done under the conditions of being 80 DEG C in temperature
Particle diameter is obtained after dry 4 hours for 1.5mm, heap density are the flavones essence cigarette pearl of 1.4g/ml.
Table 6
| Flavones species | Puerarin | Quercetin | Catechol | Hesperetin |
| Percentage by weight | 40% | 10% | 20% | 30% |
For caused by smoking " cough, abundant expectoration, pant " three big symptoms, with reference to classical respiratory tract antibechic, eliminating the phlegm, relieving asthma
Pharmacodynamic evaluation method on the basis of, from various different living models screen set up exhaled suitable for natural plant extracts
The method for inhaling pipe protection effect assessment, evaluates the phenol red excretion method of antitussive effect, mouse and evaluates eliminating the phlegm using ammonia induced cough in mice
Effect, Guinea pig isolated trachea spiral strip method evaluate antiasthmatic effect.
Flavones essence cigarette pearl prepared in 6 embodiments is added in pipe tobacco by more than, and then the cigarette being made is entered
Row detection of exhaust gas compositions, and carry out phenol reduced rate and compare, it is specifically shown in table 7 below
Table 7
*P<0.05,**P<0.01 compares with equal number blank cigarette group
Flavones essence cigarette pearl prepared in 6 embodiments is added in pipe tobacco by more than, and then the cigarette being made is entered
Row sensory evaluation, as a result such as table 8
Table 8
The above, specific embodiment only of the invention, but protection scope of the present invention is not limited thereto, and it is any
Belong to those skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in, all should
It is included within the scope of the present invention.Therefore, protection scope of the present invention should be defined by scope of the claims.
Claims (5)
1. a kind of cigarette preparation method of flavones essence cigarette pearl, it is characterised in that：The preparation method is as follows：
The adhesive that weight is flavones essence weight 0.1%~1% is weighed, flavones essence is added to after adhesive water dissolves
In, stir and be made softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then
It is round as a ball by spheronizator, particle size range is obtained after drying for 0.5mm~4mm, heap density are the flavones of 1.2g/ml~1.8g/ml
Essence cigarette pearl；Described adhesive is in PVP, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and carboxymethylcellulose calcium
Plant or various, the drying is dried 4~6 hours under the conditions of temperature is for 60 DEG C~80 DEG C；
Wherein：The weight percentages of components of the flavones essence is as follows：
2. the cigarette according to claim 1 preparation method of flavones essence cigarette pearl, it is characterised in that：The Puerarin, Mongolian oak
The DNA purity of Pi Su, catechol and hesperetin is 80~95%.
3. the cigarette according to claim 1 preparation method of flavones essence cigarette pearl, it is characterised in that：The particle diameter of the cigarette pearl
Scope is 0.8mm~1.5mm, and heap density is 1.4g/ml~1.6g/ml.
4. a kind of cigarette is with flavones essence cigarette pearl, it is characterised in that：The flavones essence cigarette pearl prepares for claim 1 methods described
Flavones essence cigarette pearl.
5. a kind of cigarette application of flavones essence cigarette pearl, it is characterised in that：By flavones essence cigarette pearl by weight percentage 0.1~
5.0：100 are added in pipe tobacco and are made cigarette, and the flavones essence cigarette pearl is flavones essence prepared by claim 1 methods described
Cigarette pearl.
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| CN109330016A (en) * | 2018-11-14 | 2019-02-15 | 河南中烟工业有限责任公司 | A kind of Exocarpium Citri Grandis medicinal extract, preparation method and the application in cigarette |
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| CN101974367B (en) * | 2009-06-23 | 2012-12-12 | 湖北中烟工业有限责任公司 | Novel flavor-enhancing and harm-reducing natural spice for tobacco and use thereof |
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