CN105154227B - Cigarette plant flavone essence cigarette pearl, preparation method and application - Google Patents

Cigarette plant flavone essence cigarette pearl, preparation method and application Download PDF

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Publication number
CN105154227B
CN105154227B CN201510337692.3A CN201510337692A CN105154227B CN 105154227 B CN105154227 B CN 105154227B CN 201510337692 A CN201510337692 A CN 201510337692A CN 105154227 B CN105154227 B CN 105154227B
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cigarette
plant flavone
essence
flavone essence
pearl
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CN105154227A (en
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宋旭艳
李冉
魏敏
罗诚浩
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China Tobacco Hunan Industrial Co Ltd
Huanghelou Science and Technology Park Group Co Ltd
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China Tobacco Hunan Industrial Co Ltd
Huanghelou Science and Technology Park Group Co Ltd
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Abstract

The present invention discloses a kind of cigarette plant flavone essence cigarette pearl, preparation method and application, weigh the adhesive that weight is plant flavone essence weight 0.1%~1%, it is added in plant flavone essence after adhesive water dissolution, it first passes through extruder and is extruded into elongated strip, then it is round as a ball by spheronizator, obtain plant flavone essence cigarette pearl after dry;The weight percentages of components for stating plant flavone essence includes 20%~60% cyanidenon, 20%~60% scutelloside, 10%~30% Kaempferol, 10%~30% aurantiin.The plant flavone essence cigarette pearl of the present invention has excellent natural breath, is brought to cigarette and comfortably smells fragrant feeling, and when cigarette is aspirated, these substances crack out the aroma component that can increase perfume quantity and aroma quality through burning;The active constituent of the plant flavone essence cigarette pearl of the present invention enters human oral cavity in cigarette with flue gas, can directly act on throat, plays the role of good raising throat comfort.

Description

Cigarette plant flavone essence cigarette pearl, preparation method and application
Technical field
The invention belongs to technical field of cigarettes, and in particular to a kind of cigarette is with plant flavone essence cigarette pearl, preparation method and answers With.
Background technology
Natural plants are widely used in tobacco aromaticss, wherein being much containing Flavonoid substances.According to Flavonoid substances Molecular characterization and interelectric active force power, Primary Study find such substance burning crack after can generate Furans and its derivative, these substances are the main aroma components in flue gas, can be brought camerlsed to flue gas, it is fragrant and sweet, Roasting perfume, increases perfume quantity and aroma quality.Therefore in the allotment of essence spice for cigarette, there is the use of many flavonoids perfume materials.
Many researchs also indicate that, flavone compound has multiple biological activities, except using its antibacterial, anti-inflammatory, anti-mutation, Outside the effects that decompression, clearing heat and detoxicating, calm, diuresis, in anti-oxidant, anticancer, anti-cancer, lipase etc. is inhibited also to have notable effect Fruit.It is the scavenger of most of oxygen radicals, thus the vigor of energy increased SOD (superoxide dismutase), reduces MDA (fat Matter peroxide malonaldehyde) and OX-LDL (OxLDL ELISA) generation.It can increase coronary flow, to experiment Myocardial inyaretion has antagonism;There is protective effect to acute myocardial ischemia;Have to treatment coronary heart diseases and angina pectoris, hypertension etc. Remarkable result;To reducing diastolic pressure, prevention arrhythmia cordis, cardiovascular disease and promoting blood circulation and removing blood stasis also play an important role.
The smog that a large amount of scientific research is demonstrated from different angles in tobacco is chronic respiratory disease, coronary heart disease Etc. the pathogenetic important risk factor of a variety of diseases.Long-term smoker generally has cough, abundant expectoration, the symptom of throat itch, seriously Influence health and the quality of life of the mankind.In addition, passive smoking also results in harm to the health of women.In order to mitigate tobacco Harm of the middle smog to human body, in positive publicity, Smoking is harmful to your health and while advice smoking cessation, also should active development have The harm reduction cigarette of the effects that easypro larynx.
Throat is the important component of respiratory tract, positioned at the important of the confluce and human body pronunciation of tracheae and esophagus Organ.When smoker is in smoking, be most vulnerable to harmful substances from flue gases influence is exactly throat.Tar easily retains in flue gas In the internal of smoking people, a kind of emplastic is condensed into lung, is attached to the trachea-bronchial epithelial cell and alveolar surface of smoker, Physics, chemical stimulation are generated, influences the breathing of human body;The defense function of bottleneck throat mucous membrane can be reduced by smoking for a long time, it may appear that Dry cough, throat's shouting pain bring sense of discomfort when feelings or when smoking causes irascibility excessively prosperous to throat;Human body is exhaled so smoking The harm for inhaling road, particularly throat is larger, is with the passing of time likely to result in laryngeal pathological process.
A large amount of correlative studys find the organ that respiratory tract is stimulated as direct body contact's ambient atmos, are that tobacco damages The person of being primarily subjected to.And airway epithelial cell resists the first line of defence of environmental stimuli as respiratory tract, suffered harm is particularly tight Weight.Previously researches show that cigarette stimulation can adjust alveolar epithelium and bronchiolar epithelium plasma urokinase-type plasminogen activator (Urokinase type plasminogen activator, uPA), uPAR Research (urokinase type plasminogen activator receptor, uPAR) system expression changes, alveolar epithelial cells The up-regulation of uPA and uPAR levels is more notable, uPA advantage states is presented, conducive to proteolysis.Urine is then presented in bronchial epithelial cell Kinases type Plasminogen Activator Inhibitor-1 (plasminogen activator inhibitor-1, PAI-1) advantage shape State is conducive to fibrosis and is formed.Two kinds of cells are possible to uPA system expression states difference can be with partial interpretation COPD patient lung qi The reason of swollen and small airway fibrosis both different pathologicals variation.It is another to have document report lung tissue of rats slice and smoke from cigarette Extract is incubated jointly, can increase lung tissue of rats lactic dehydrogenase (lactatec dehydrogenate, LDH) leak out and Nitrite NO2- discharges, and stimulation nitric oxide synthase type (induced nitric oxide synthase, iNOS) is living Property increase, lead to injury of lungs.It can be seen that long-term fume exposure can cause airway epithelial cell form and function damage, from And the normal physiological function of upper lower respiratory tract is influenced, smoker is made to generate uncomfortable feeling or even seriously affect life quality (quality of life, QOF) and life security.From consumer's interests are safeguarded, the road of reducing tar and reducing harm is walked, is Chinese style volume The developing direction of cigarette.Under the premise of consumer's physiology, psychological needs are met, its unfavorable shadow brought to consumer throat is reduced It rings, promotes throat's comfort, be tobacco business scientific research personnel's urgent problem to be solved.
Throat's comfort well refer to consumer when product inhale cigarette the smooth exquisiteness of the flue gas experienced, oral cavity noresidue, Nose larynx is non-stimulated, aftertaste has the impressions such as sweet tea sense.Laryngeal response is concentrated mainly on oral cavity and respiratory system during the smoking process The impression at position is embodied in the improvement of drop thorn, resolving sputum, promote the production of body fluid etc., can preferably realize suction comfort.
Drop thorn:Irritation refers to impact of the flue gas to sense organ.It is divided into oral stimulation, nasal cavity stimulation and throat's thorn in impression Swash three kinds.Irritation is big, seemingly there is " peppery " taste in oral cavity, can draw tears from sb or shed tears sense in nasal cavity, can make throat in throat Deflation causes cough.
The irritation of flue gas is mainly excessive by acid excessive in cigarette and alkalinity and generates, at the same with the water of cigarette Point, tightness etc. it is also related.Peppery thorn is since alkaline matter is on the high side;Thorn of choking is since small molecule shot-like particle is on the high side;Spine (hair Thorn) it is since acidic materials are on the high side.
Flavone compound has the function of diastole bronchial smooth muscle, adds in cigarette, can weaken the contracting of flue gas Pipe acts on, and it is uncomfortable caused by throat to alleviate smoke-shock.
Resolving sputum:The people of long-term smoker generally has a degree of pharyngitis, and performance is abundant expectoration and frequency.Having in flue gas Evil substance is frequently gathered in respiratory tract, caused by accelerating the wriggling of villus fiber.
Flavone compound can reduce flue gas life phlegm substance, certainly will can reduce heap of the constituents in respiratory system Product.In addition, flavone compound can speed up tracheae villus fiber wriggling, harmful substance is made quickly to be excluded with juice external, This resolving sputum effect just played to a certain extent.
It promotes the production of body fluid:Tianjin is saliva, and it is exactly to make to secret out of saliva in oral cavity to promote the production of body fluid.Modern medicine is it also holds that containing more in saliva Helpful body composition is planted, promoting the production of body fluid in mouth, it is easypro suitable to quench one's thirst.
The effect of a variety of flavone compounds have nourishing Yin and promoting production of body fluid, and moistening lung is relieved inflammation or internal heat, Heat Diabetes.Addition, can in cigarette Oral cavity taste bud is stimulated with effect of promoting the production of body fluid, flue gas is more mellow and fuller, with sweet tea sense is returned, reduces to dry up and feel.
Much contain Flavonoid substances in tobacco aromaticss, but for specifically for improve throat's comfort, have cough-relieving, Resolving sputum, effect of relievining asthma composition have not been reported, need for further study.
The cigarette pearl containing essence and flavoring agent is put into filter tip in the prior art, which can make cigarette in aspiration procedure In it is more raw fragrant, strengthen fragrance or characteristic, smoker made to obtain more comfortably experiencing.This cigarette pearl can only simply make cigarette It is raw fragrant in aspiration procedure, it is impossible to play cough-relieving, resolving sputum, effect of relievining asthma.
Invention content
In view of the deficiencies of the prior art, present invention offer is a kind of has effects that cough-relieving, resolving sputum, the cigarette plant flavone relievingd asthma Cigarette is added to plant flavone essence cigarette pearl in pipe tobacco by essence cigarette pearl, preparation method and application, during the smoking process, hair Its excellent anti-inflammatory, sharp larynx effect is waved, so as to improve throat's comfort of cigarette smoking, improves cigarette smoking quality.
Technical solution is used by the present invention solves above-mentioned technical problem:A kind of cigarette plant flavone essence cigarette pearl is provided Preparation method, the preparation method is as follows:
The adhesive that weight is plant flavone essence weight 0.1%~1% is weighed, plant is added to after adhesive water dissolution In object flavones essence, stir evenly and softwood be made, then by extrusion-spheronizator on softwood, first pass through extruder be extruded into it is elongated Strip, it is then round as a ball by spheronizator, obtain that particle size range is 0.5mm~4mm, heap density is 1.2g/ml~1.8g/ after dry The plant flavone essence cigarette pearl of ml;
Wherein:The weight percentages of components of the plant flavone essence is as follows:
Further, the DNA purity of the catechin, cyanidenon, hesperetin and Kaempferol is 80~95%.
Further, described adhesive is povidone, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and carboxymethyl cellulose It is one or more in element.
Further, the particle size range of the cigarette pearl is 0.8mm~1.5mm, and heap density is 1.4g/ml~1.6g/ml.
Further, it in temperature is 4~6 hours dry under the conditions of 60 DEG C~80 DEG C that the drying, which is,.
A kind of cigarette is plant prepared by method described above with plant flavone essence cigarette pearl, the plant flavone essence cigarette pearl Flavones essence cigarette pearl.
A kind of application of plant flavone essence cigarette pearl of cigarette, by plant flavone essence cigarette pearl by weight percentage 0.1~ 5.0:100 are added in pipe tobacco cigarette are made, and the plant flavone essence cigarette pearl is plant flavone prepared by method described above Essence cigarette pearl.
The present invention has the following advantages:
1st, plant flavone essence cigarette pearl of the invention has excellent natural breath, is brought to cigarette and comfortably smells fragrant sense Feel, when cigarette is aspirated, these substances crack out the aroma component that can increase perfume quantity and aroma quality through burning, are further promoted Cigarette smoking quality;
2nd, the active constituent of plant flavone essence cigarette pearl of the invention enters human oral cavity, Ke Yizhi in cigarette with flue gas It connects and acts on throat, play the role of good raising throat comfort;
3rd, plant flavone essence cigarette pearl of the present invention is added in the tobacco, does not increase any production process, simple and practicable, Be conducive to industrial-scale production;
4th, plant flavone flavor of raw material of the present invention derives from a wealth of sources, of low cost, easy to utilize.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.The specific embodiments described herein are merely illustrative of the present invention, is not used to limit this hair It is bright.
Embodiment 1
Plant flavone essence according to ratio in table 1 is mixed, weighs the hydroxypropyl that weight is plant flavone essence weight 0.1% Ylmethyl cellulosic binders with being added in plant flavone essence after 400ml water dissolutions, stir evenly and softwood are made, then By extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then round as a ball by spheronizator, upper fluid bed exists The plant flavone essence cigarette pearl that grain size is 0.5mm, heap density is 1.8g/ml is obtained after temperature is 6 hours dry under the conditions of being 60 DEG C.
Table 1
Flavones type Cyanidenon Scutelloside Kaempferol Aurantiin
Weight percent 30% 20% 30% 20%
Embodiment 2
Plant flavone essence according to ratio in table 2 is mixed, weighs the hydroxypropyl that weight is plant flavone essence weight 0.5% Ylmethyl cellulosic binders with being added in plant flavone essence after 450ml water dissolutions, stir evenly and softwood are made, then By extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then round as a ball by spheronizator, upper fluid bed exists The plant flavone essence cigarette that grain size is 0.8mm, heap density is 1.6g/ml is obtained after temperature is 5.5 hours dry under the conditions of being 65 DEG C Pearl.
Table 2
Flavones type Cyanidenon Scutelloside Kaempferol Aurantiin
Weight percent 30% 30% 20% 20%
Embodiment 3
Plant flavone essence according to ratio in table 3 is mixed, weighs the carboxylic first that weight is plant flavone essence weight 0.8% Base cellulosic binders with being added in plant flavone essence after 500ml water dissolutions, stir evenly and softwood are made, then will be soft Extrusion-spheronizator on material first passes through extruder and is extruded into elongated strip, and then round as a ball by spheronizator, upper fluid bed is in temperature Drying obtains the plant flavone essence cigarette pearl that grain size is 1.0mm, heap density is 1.6g/ml after 6 hours under the conditions of being 70 DEG C.
Table 3
Flavones type Cyanidenon Scutelloside Kaempferol Aurantiin
Weight percent 40% 30% 15% 15%
Embodiment 4
Plant flavone essence according to ratio in table 4 is mixed, weighs the carboxylic first that weight is plant flavone essence weight 0.8% Base cellulosic binders with being added in plant flavone essence after 500ml water dissolutions, stir evenly and softwood are made, then will be soft Extrusion-spheronizator on material first passes through extruder and is extruded into elongated strip, and then round as a ball by spheronizator, upper fluid bed is in temperature Drying obtains the plant flavone essence cigarette pearl that grain size is 1.5mm, heap density is 1.4g/ml after 6 hours under the conditions of being 75 DEG C.
Table 4
Flavones type Cyanidenon Scutelloside Kaempferol Aurantiin
Weight percent 40% 40% 10% 10%
Embodiment 5
Plant flavone essence according to ratio in table 5 is mixed, weighs the hydroxypropyl that weight is plant flavone essence weight 1% Cellulosic binders with being added in plant flavone essence after 550ml water dissolutions, stir evenly and softwood are made, then by softwood Upper extrusion-spheronizator first passes through extruder and is extruded into elongated strip, and then round as a ball by spheronizator, upper fluid bed is in temperature Drying obtains the plant flavone essence cigarette pearl that grain size is 1.5mm, heap density is 1.4g/ml after 5 hours under the conditions of 70 DEG C.
Table 5
Flavones type Cyanidenon Scutelloside Kaempferol Aurantiin
Weight percent 20% 20% 30% 30%
Embodiment 6
Plant flavone essence according to ratio in table 6 is mixed, weighs the hydroxypropyl that weight is plant flavone essence weight 1% Cellulosic binders with being added in plant flavone essence after 550ml water dissolutions, stir evenly and softwood are made, then by softwood Upper extrusion-spheronizator first passes through extruder and is extruded into elongated strip, and then round as a ball by spheronizator, upper fluid bed is in temperature Drying obtains the plant flavone essence cigarette pearl that grain size is 1.5mm, heap density is 1.4g/ml after 4 hours under the conditions of 80 DEG C.
Table 6
Flavones type Cyanidenon Scutelloside Kaempferol Aurantiin
Weight percent 25% 25% 25% 25%
For caused by smoking " cough, is panted at abundant expectoration " three big symptoms, in the classical respiratory tract antibechic of reference, eliminating the phlegm, relieving asthma Pharmacodynamic evaluation method on the basis of, from a variety of different biological models screening establish exhaled suitable for natural plant extracts The method of pipe protection effect assessment is inhaled, eliminating the phlegm is evaluated using ammonia induced cough in mice evaluation antitussive effect, the phenol red excretion method of mouse Effect, Guinea pig isolated trachea spiral strip method evaluation antiasthmatic effect.
Plant flavone essence cigarette pearl prepared in above 6 embodiments is added in pipe tobacco, then to manufactured cigarette Zhi Jinhang detection of exhaust gas compositions, and carry out phenol reduced rate and compare, it is specifically shown in the following table 7
Table 7
*P<0.05,**P<0.01 compared with equal number blank cigarette group
Plant flavone essence cigarette pearl prepared in above 6 embodiments is added in pipe tobacco, then to manufactured cigarette Zhi Jinhang sensory evaluations, as a result such as table 8
Table 8
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any Belong to those skilled in the art in the technical scope disclosed by the present invention, the change or replacement that can be readily occurred in all should It is included within the scope of the present invention.Therefore, protection scope of the present invention should be subject to the protection scope in claims.

Claims (3)

1. a kind of cigarette preparation method of plant flavone essence cigarette pearl, it is characterised in that:The preparation method is as follows:
The adhesive that weight is plant flavone essence weight 0.1%~1% is weighed, plant Huang is added to after adhesive water dissolution It in ketone essence, stirs evenly and softwood is made, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated item Shape, it is then round as a ball by spheronizator, obtain that particle size range is 0.5mm~4mm, heap density is 1.2g/ml~1.8g/ml after dry Plant flavone essence cigarette pearl;
Wherein:The weight percentages of components of the plant flavone essence is as follows:
Described adhesive be povidone, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and carboxymethyl cellulose in one kind or It is a variety of;It in temperature is 4~6 hours dry under the conditions of 60 DEG C~80 DEG C that the drying, which is,.
2. a kind of cigarette is with plant flavone essence cigarette pearl, it is characterised in that:The plant flavone essence cigarette pearl is described in claim 1 Plant flavone essence cigarette pearl prepared by method.
3. a kind of cigarette application of plant flavone essence cigarette pearl, it is characterised in that:By plant flavone essence cigarette pearl by weight 0.1 ~5.0:100 are added in pipe tobacco cigarette are made, and the plant flavone essence cigarette pearl is plant prepared by claim 1 the method Object flavones essence cigarette pearl.
CN201510337692.3A 2015-06-17 2015-06-17 Cigarette plant flavone essence cigarette pearl, preparation method and application Active CN105154227B (en)

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106617262B (en) * 2016-12-14 2017-11-07 湖北中烟工业有限责任公司 One grows tobacco buccal tablet and preparation method thereof
CN109330016A (en) * 2018-11-14 2019-02-15 河南中烟工业有限责任公司 A kind of Exocarpium Citri Grandis medicinal extract, preparation method and the application in cigarette
CN110353298A (en) * 2019-08-30 2019-10-22 深圳雾芯科技有限公司 Electronic cigarette liquid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101016288A (en) * 2007-03-06 2007-08-15 川渝中烟工业公司 Method of stabilizing bioactivity of flavones substance
CN101653290A (en) * 2009-08-26 2010-02-24 甘全军 Cigarette containing rosmarinic acid and preparation method thereof
CN101864694A (en) * 2010-06-13 2010-10-20 玉溪市星源油墨厂 Tea flavonoids containing water-based coating for cigarette plug wrap paper
CN102061174A (en) * 2010-10-29 2011-05-18 华南农业大学 Squalene and tea polyphenol composition and application thereof in cigarettes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101016288A (en) * 2007-03-06 2007-08-15 川渝中烟工业公司 Method of stabilizing bioactivity of flavones substance
CN101653290A (en) * 2009-08-26 2010-02-24 甘全军 Cigarette containing rosmarinic acid and preparation method thereof
CN101864694A (en) * 2010-06-13 2010-10-20 玉溪市星源油墨厂 Tea flavonoids containing water-based coating for cigarette plug wrap paper
CN102061174A (en) * 2010-10-29 2011-05-18 华南农业大学 Squalene and tea polyphenol composition and application thereof in cigarettes

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