CN102061174A - Squalene and tea polyphenol composition and application thereof in cigarettes - Google Patents
Squalene and tea polyphenol composition and application thereof in cigarettes Download PDFInfo
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- CN102061174A CN102061174A CN201010529711XA CN201010529711A CN102061174A CN 102061174 A CN102061174 A CN 102061174A CN 201010529711X A CN201010529711X A CN 201010529711XA CN 201010529711 A CN201010529711 A CN 201010529711A CN 102061174 A CN102061174 A CN 102061174A
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Abstract
The invention provides a squalene and tea polyphenol composition and an application thereof in cigarettes. The composition comprises 0.05-60% of squalene, 0.05-60% of tea polyphenol and the balance of solvent by weight. By the synergic effect of the squalene and the tea polyphenol, the invention achieves the purposes of simultaneously efficiently removing the solid phase free radicals in tar of the cigarettes and the gas phase free radicals in fume, and can obviously reduce the consumption of an antioxidant, thus providing a powerful technical support for solving the problem of smoking and health.
Description
Technical field
The invention belongs to technical field of chemistry, relate to a kind of natural antioxidants composition, be specifically related to the synergistic composition of squalene and two kinds of natural antioxidantss of tea-polyphenol, and the application aspect the gaseous phase free radical in solid phase free radical and the cigarette smoke in reducing coke tar in cigarette of described composition.
Background technology
Smoking and health are one of main challenges of facing in the process of advancing of tobacco industry.Tobacco industry is just paid attention to smoking and health problem since the seventies, after the eighties especially reducing objectionable constituent such as tar as main research topic, carried out many-sided research of technique, now the average releasing content of coke tar of China's cigarette from dropping to more than the 30mg/ in past props up below 16mg/ props up, has obtained major progress.
But the burning of cigarette is except that producing thousands of kinds of compounds, also produce the free radical of high density, comprise the solid phase free radical that the life-span is relatively long, the active oxygen radical such as the superoxide anion (O of quinones and semiquinone class, polycyclic aromatic hydrocarbons free radical and they and oxygen reaction generation
2 -), hydrogen peroxide (H
2O
2), hydroxy radical qiao (OH), singlet oxygen (
1O
2) relative with lifetime short gaseous phase free radical with lipid peroxidation free radical (ROO) etc., alkoxy free group (RO), alkyl diradical (R), oxynitride free radical etc.And to the health effect the strongest the most deleterious be the gaseous phase free radical of cigarette, it can cause tuberculosis, heart trouble and cancer.The crowd of these radical pairs smoker and passive suction " second-hand " cigarette can produce serious injury.
At present in to flue gas aspect the free radical scavenging research and few, mainly reduce the injury to human body of free radical the flue gas from adding natural antioxidants, VITAMIN, amino acid, protein etc. and biological enzyme free-radical scavengers and trace element, natural mineral matter.But these free-radical scavengerss all are one or more simple mixed additive generally, the ability of antioxidant for clearing free radical has certain selectivity, generally is difficult to the relative short gaseous phase free radical with lifetime of long-life solid phase free radical is played scavenging(action) simultaneously.
Squalene is a kind of lipid unsaponifiables, being a kind of many unsaturated olefins (squalene), is to find from the liver oil of shark at first, is named as Squalene in 1914, its chemical name is 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa carbon six alkene belong to the open chain triterpene, claim the Oils,glyceridic,cod-liver terpene again, participate in body's cholesterol and synthesize also and can enhance metabolism, have superoxide dismutase enhancement (SOD) activity, the enhancing body immunological competence, anti-ageing, antifatigue, different physiological roles such as antitumor is a kind of avirulent marine bioactivity material with the effect of preventing and curing diseases.Squalene distributes very wide in plant, but content is not high, is lower than 5% of unsaponifiables in the vegetables oil more, and only minority content is more, contains squalene 150～700mg/100g as sweet oil, and its content is 332mg/100g in the Rice pollard oil.
Tea-polyphenol is the general name of catechin in the tealeaves, acetone class, phenolic acids and anthocyan compound.Be a kind of condensed ring aromatic hydrocarbon, can be divided into flavanol compound, hydroxyl-[4]-flavanol compound, anthocyanin class, flavonoid, flavonols and phenolic acids etc.Wherein important with catechin, account for 60%～80% of Polyphenols total amount; Catechin mainly is made up of several monomers such as EGC, DLC, EC, EGCG, GCG, ECG.The content of tea-polyphenol in tealeaves is generally 20～35%.Based on flavanol compound, flavanol compound was again based on catechins during each was formed part in tea-polyphenol.The content of catechins accounts for about 70% of tea-polyphenol total amount.Effect with the harmful free radical of very strong elimination, anti-aging effects, radiation resistance, to the restraining effect of cancer cells, antibiotic, germicidal action is to the restraining effect of hiv virus, the existing tea-polyphenol that studies have shown that is also beneficial to the smoker, can clean lung's Nicotine.
At present relevant squalene and tea-polyphenol be mixed synergy research also seldom, any technology report is not seen in the research that especially is applied to the production of cigarettes aspect as yet.
Summary of the invention
The objective of the invention is to overcome the deficiency of free radical scavenging technology in the existing cigarette product, a kind of natural squalene and the tea-polyphenol antioxidant synergistic composition that is mixed is provided.By squalene and tea-polyphenol reasonably are mixed, reach synergistic function between the two, the purpose of realize having complementary advantages, acquisition can efficiently be removed the natural free-radical scavengers composition of gaseous phase free radical in solid phase free radical in the coke tar in cigarette and the flue gas simultaneously.
Purpose of the present invention is achieved by the following technical programs:
A kind of squalene and tea-polyphenol composition are provided, by weight, comprise 0.05～60% squalene, 0.05～60% tea-polyphenol and the solvent of surplus.
Preferably, described squalene and tea-polyphenol composition by weight, comprise 0.5～50% squalene, 1～50% tea-polyphenol and the solvent of surplus.
Preferably, the part by weight that described squalene and tea-polyphenol are mixed is 1: 10～10: 1, and more preferably the part by weight that is mixed of squalene and tea-polyphenol is 1: 5～5: 1.
It is 60%～90% aqueous ethanolic solution that described solvent can be selected volume by volume concentration for use, preferred 70%.
Described squalene can be the extract that from plant, animal or microorganism, extracts or purified after pure product, can adopt commercial product.
Described tea-polyphenol can be that the tea-polyphenol extract that extracts from tealeaves also can be the pure product after purified, can adopt commercial product.
The present invention provides the application of described squalene and tea-polyphenol composition simultaneously, is applied to production of cigarettes.
Main application is that described composition is directly added in the cigarette shreds, the solid phase free radical of the tar that produces when being used for reducing cigarette burning and the gaseous phase free radical in the cigarette smoke.
Preferably, the ratio of interpolation is the described composition of 0.1～2g: the 100g pipe tobacco.
The invention has the beneficial effects as follows:
1, the ability of the removing free radical of the present invention's composition of selecting squalene and tea-polyphenol rationally to be mixed to obtain improves greatly, obtains obvious synergistic effect, can obviously reduce usage quantity.
2, the present invention adopts the suitable scheme that is mixed, after squalene and tea-polyphenol rationally be mixed, make squalene and tea-polyphenol bring into play synergistic function preferably, reach the simultaneously efficient usage quantity of removing in the coke tar in cigarette purpose of gaseous phase free radical in the solid phase free radical and flue gas and can obviously reducing antioxidant, provide strong technical support with healthy problem for solving smoking.
Embodiment
Below in conjunction with further describing the present invention in concrete the enforcement.Employed test method is ordinary method if no special instructions among the following embodiment; Employed material, reagent etc. if no special instructions, are the reagent and the material that can obtain from commercial channels.
Embodiment 1 squalene and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 0.05% squalene+1% tea-polyphenol+surplus.
Embodiment 2 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 0.1% squalene+1% tea-polyphenol+surplus.
Embodiment 3 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 0.2% squalene+1% tea-polyphenol+surplus.
Embodiment 4 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+1% tea-polyphenol+surplus.
Embodiment 5 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+0.05% tea-polyphenol+surplus.
Embodiment 6 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+0.1% tea-polyphenol+surplus.
Embodiment 7 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+0.2% tea-polyphenol+surplus.
Embodiment 8 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, promptly.
The solvent of 5% squalene+50% tea-polyphenol+surplus.
Embodiment 9 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, promptly.
The solvent of 5% squalene+25% tea-polyphenol+surplus.
Embodiment 10 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, promptly.
The solvent of 5% squalene+5% tea-polyphenol+surplus.
Embodiment 11 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 25% squalene+5% tea-polyphenol+surplus.
Embodiment 12 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 50% squalene+5% tea-polyphenol+surplus.
Embodiment 13 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 30% squalene+60% tea-polyphenol+surplus.
Embodiment 14 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 30% squalene+45% tea-polyphenol+surplus.
Embodiment 15 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, promptly.
The solvent of 30% squalene+30% tea-polyphenol+surplus.
Embodiment 16 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, promptly.
The solvent of 45% squalene+30% tea-polyphenol+surplus.
Embodiment 17 squalenes and tea-polyphenol preparation of compositions
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, promptly.
The solvent of 60% squalene+30% tea-polyphenol+surplus.
The preparation of embodiment 18 squalene solution
According to the following weight ratio a certain amount of squalene being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% squalene+surplus.
The preparation of embodiment 19 squalene solution
According to the following weight ratio a certain amount of squalene being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, promptly.
The solvent of 60% squalene+surplus.
The preparation of embodiment 20 tea-polyphenol solution
According to the following weight ratio a certain amount of tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 1% tea-polyphenol+surplus.
The preparation of embodiment 21 tea-polyphenol solution
According to the following weight ratio a certain amount of tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, promptly.
The solvent of 60% tea-polyphenol+surplus.
Embodiment 22 application experiments
In the production of cigarettes technology for making tobacco threds, program according to flavoring and casing, be mixed composition and squalene or tea-polyphenol solution in the foregoing description 1～21 are sprayed onto on the pipe tobacco continuously equably, the pipe tobacco that is sprayed with composition, squalene or tea-polyphenol solution are dried in the pipe tobacco water content after between 11%～13%, make cigarette with this area ordinary method again in 10 ℃ cold wind.Being sprayed with composition on per 100 gram pipe tobaccos and being respectively 0.1,1 and 2 grams, is contrast with 70% aqueous ethanolic solution that does not contain squalene or tea-polyphenol.
Free radical scavenging effect detection in the cigarette smoke: free radical adopts spectrum (ESR) technology to detect in the coke tar in cigarette, smoke gaseous phase free radical adopts spin catching agent PBN (2-benzene tert-butylnitrone) to capture the back and detects, and tar solid phase free radical adopts cambridge filter to capture the back and detects.
Adopt conventional gaseous phase free radical detection method: adopt glassware to collect the flue gas free radical.The carbon tetrachloride solution that adds certain density free radical scavenger PBN is linked collector on the smoking machine in collector, is 35.0mL with the suction capacity, and suction time is 2s, and suction is spaced apart the standard suction speed smoking cigarette of 60s.Constant volume is collected the flue gas free-atom aqueous solution after the smoking, and it is freezing then to put into liquid nitrogen.Detection volume is 200 μ L.
Solid phase free radical detection method: after the smoking cambridge filter is taken off, cut out down 1/10th filter disc and pack into and carry out ESR in the 3mm diameter silica tube and detect.
By detecting the content that the natural antioxidants synergistic composition cigarette that adds different content and different proportionings produces free radical, compared with the control, calculation composition is to the removing effect of solid phase free radical and gaseous phase free radical in the cigarette smoke.Experimental result is as follows:
Add 0.1 gram composition to solid phase free radical in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 1
| Sample | Solid phase free radical scavenging activity (%) | Gaseous phase free radical clearance rate (%) |
| Embodiment 1 | 3.14 | 3.67 |
| Embodiment 2 | 3.62 | 4.01 |
| Embodiment 3 | 3.81 | 4.15 |
| Embodiment 4 | 5.37 | 6.17 |
| Embodiment 5 | 2.38 | 3.07 |
| Embodiment 6 | 2.57 | 3.09 |
| Embodiment 7 | 2.72 | 3.20 |
| Embodiment 8 | 8.51 | 9.32 |
| Embodiment 9 | 6.63 | 8.73 |
| Embodiment 10 | 6.83 | 9.91 |
| Embodiment 11 | 9.39 | 10.27 |
| Embodiment 12 | 10.34 | 11.67 |
| Embodiment 13 | 13.31 | 15.61 |
| Embodiment 14 | 15.42 | 18.91 |
| Embodiment 15 | 14.34 | 17.55 |
| Embodiment 16 | 16.41 | 19.97 |
| Embodiment 17 | 18.53 | 20.64 |
| Embodiment 18 | 0.93 | 2.86 |
| Embodiment 19 | 5.92 | 8.83 |
| Embodiment 20 | 2.67 | 1.02 |
| Embodiment 21 | 7.37 | 3.08 |
Add 1 gram composition to solid phase free radical in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 2
| Sample | The solid phase free radical scavenging activity | The gaseous phase free radical clearance rate |
| Embodiment 1 | 4.27 | 5.69 |
| Embodiment 2 | 5.61 | 6.37 |
| Embodiment 3 | 6.29 | 7.27 |
| Embodiment 4 | 7.92 | 9.17 |
| Embodiment 5 | 3.17 | 3.92 |
| Embodiment 6 | 3.98 | 5.91 |
| Embodiment 7 | 4.93 | 6.37 |
| Embodiment 8 | 25.67 | 29.59 |
| Embodiment 9 | 21.61 | 23.17 |
| Embodiment 10 | 15.27 | 17.34 |
| Embodiment 11 | 27.64 | 29.61 |
| Embodiment 12 | 31.28 | 35.61 |
| Embodiment 13 | 37.61 | 42.94 |
| Embodiment 14 | 35.67 | 37.19 |
| Embodiment 15 | 32.61 | 35.27 |
| Embodiment 16 | 39.61 | 43.82 |
| Embodiment 17 | 42.29 | 45.61 |
| Embodiment 18 | 1.38 | 4.07 |
| Embodiment 19 | 8.27 | 13.64 |
| Embodiment 20 | 5.01 | 2.82 |
| Embodiment 21 | 12.31 | 6.28 |
Add 2 gram compositions to solid phase free radical in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 3
| Sample | The solid phase free radical scavenging activity | The gaseous phase free radical clearance rate |
| Embodiment 1 | 6.01 | 7.34 |
| Embodiment 2 | 6.62 | 7.98 |
| Embodiment 3 | 7.24 | 8.37 |
| Embodiment 4 | 10.35 | 12.92 |
| Embodiment 5 | 5.27 | 6.91 |
| Embodiment 6 | 6.31 | 7.24 |
| Embodiment 7 | 7.28 | 9.01 |
| Embodiment 8 | 30.24 | 33.61 |
| Embodiment 9 | 28.33 | 30.17 |
| Embodiment 10 | 23.64 | 26.91 |
| Embodiment 11 | 29.27 | 31.64 |
| Embodiment 12 | 33.67 | 37.29 |
| Embodiment 13 | 38.61 | 43.19 |
| Embodiment 14 | 36.92 | 39.57 |
| Embodiment 15 | 34.67 | 36.92 |
| Embodiment 16 | 40.28 | 45.61 |
| Embodiment 17 | 44.52 | 46.37 |
| Embodiment 18 | 2.67 | 5.32 |
| Embodiment 19 | 9.18 | 14.37 |
| Embodiment 20 | 6.94 | 3.15 |
| Embodiment 21 | 13.18 | 7.08 |
Experiment conclusion: to cigarette gaseous phase free radical and solid phase free radical scavenging effect as can be seen from the foregoing description, when the addition of composition according to 0.1 gram composition: during 100 gram pipe tobaccos, it has certain removing effect simultaneously to solid phase free radical and gas phase freedom, particularly work as the proportioning of squalene and tea-polyphenol between 1: 10～10: 1, especially in the time of between 1: 5～5: 1, composition has obvious synergistic effect to solid phase and gas phase free radical scavenging effect.When the addition of composition during at 1 gram/100 gram pipe tobaccos, it has tangible removing effect simultaneously to cigarette solid phase and gaseous phase free radical, and the weight proportion of working as squalene and tea-polyphenol is between 1: 10～10: 1, especially in the time of between 1: 5～5: 1, composition has obvious synergistic effect to solid phase and gas phase free radical scavenging effect, for single agent, remove effect and improved 3～7 times.When the addition of composition during at 2 grams/100 gram pipe tobaccos, for single agent, composition also has obvious synergistic effect to the removing ability of cigarette solid phase and gaseous phase free radical, but for addition was 1 gram/100 gram pipe tobaccos, otherness was not remarkable between the two.Actual according to producing, the present invention is used for the natural antioxidants composition of cigarette, its the removing ability synergism to solid phase and gaseous phase free radical between 1: 10～10: 1 of the proportioning of squalene and tea-polyphenol is obvious, and per 100 gram pipe tobaccos interpolation amount of composition are suitable between 0.1～2 gram.
Claims (9)
1. squalene and tea-polyphenol composition is characterized in that by weight, comprise 0.05～60% squalene, 0.05～60% tea-polyphenol and the solvent of surplus.
2. according to described squalene of claim 1 and tea-polyphenol composition, it is characterized in that comprising by weight 0.5～50% squalene, 1～50% tea-polyphenol and the solvent of surplus.
3. according to claim 1 or 2 described squalenes and tea-polyphenol composition, it is characterized in that the part by weight that described squalene and tea-polyphenol are mixed is 1: 10～10: 1.
4. according to described squalene of claim 3 and tea-polyphenol composition, it is characterized in that the part by weight that described squalene and tea-polyphenol are mixed is 1: 5～5: 1.
5. according to claim 1 or 2 described squalenes and tea-polyphenol composition, it is characterized in that described squalene for the extract that from plant, animal or microorganism, extracts or purified after pure product.
6. according to claim 1 or 2 described squalenes and tea-polyphenol composition, it is characterized in that described tea-polyphenol also can be pure product after purified for the tea-polyphenol extract that extracts from tealeaves.
7. according to claim 1 or 2 described squalenes and tea-polyphenol composition, it is characterized in that described solvent is that volume by volume concentration is 60～90% aqueous ethanolic solutions.
8. the application of a claim 1 or 2 described squalenes and tea-polyphenol composition, it is characterized in that it being that described squalene and tea-polyphenol composition are added in the cigarette shreds, the solid phase free radical of the tar that produces when being used for reducing cigarette burning and the gaseous phase free radical in the cigarette smoke.
9. application according to claim 8 is characterized in that it being that described squalene and tea-polyphenol composition are added in the cigarette shreds according to the ratio of 0.1～2g composition/100g pipe tobacco.
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| CN103767070A (en) * | 2014-01-15 | 2014-05-07 | 中国烟草总公司广东省公司 | Preparation method of squalene and astaxanthin composition liquid precursor lipidosome and radical reducing and harm reduction application of squalene and astaxanthin composition liquid precursor lipidosome |
| CN103815545A (en) * | 2014-01-15 | 2014-05-28 | 华南农业大学 | Squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application |
| CN103859588A (en) * | 2014-03-20 | 2014-06-18 | 广西中烟工业有限责任公司 | Preparation method of squalene and astaxanthin composite multivesicular liposome and radical lowering and harm reducing method thereof |
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| CN105758954A (en) * | 2016-02-29 | 2016-07-13 | 中国烟草总公司广东省公司 | Detecting method for squalene in cigarette smoke |
| CN107890136A (en) * | 2017-11-08 | 2018-04-10 | 江苏瑾辉生物科技有限公司 | Application of the Tea Polyphenols in harmful substance volatilization in reducing smoke of tobacco |
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| CN103815545A (en) * | 2014-01-15 | 2014-05-28 | 华南农业大学 | Squalene and tea polyphenol composition multivesicular liposome preparation method and base and harm reduction application |
| CN103815545B (en) * | 2014-01-15 | 2015-09-30 | 华南农业大学 | The preparation method of squalene and tea polyphenol composition multivesicular liposome and fall base harm reduction and apply |
| CN103859588A (en) * | 2014-03-20 | 2014-06-18 | 广西中烟工业有限责任公司 | Preparation method of squalene and astaxanthin composite multivesicular liposome and radical lowering and harm reducing method thereof |
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| CN105154228A (en) * | 2015-06-17 | 2015-12-16 | 湖北中烟工业有限责任公司 | Plant flavone essence cigarette bead for cigarette and preparation method thereof |
| CN105154227A (en) * | 2015-06-17 | 2015-12-16 | 湖北中烟工业有限责任公司 | Plant flavone essence cigarette bead for cigarette, and preparation method and application thereof |
| CN105154228B (en) * | 2015-06-17 | 2018-07-03 | 湖北中烟工业有限责任公司 | Cigarette is with plant flavone essence cigarette pearl and preparation method thereof |
| CN105154227B (en) * | 2015-06-17 | 2018-07-10 | 湖北中烟工业有限责任公司 | Cigarette plant flavone essence cigarette pearl, preparation method and application |
| CN105738525A (en) * | 2016-02-29 | 2016-07-06 | 中国烟草总公司广东省公司 | High performance liquid chromatographic detection method for squalene contained in tobacco leaves |
| CN105758954A (en) * | 2016-02-29 | 2016-07-13 | 中国烟草总公司广东省公司 | Detecting method for squalene in cigarette smoke |
| CN107890136A (en) * | 2017-11-08 | 2018-04-10 | 江苏瑾辉生物科技有限公司 | Application of the Tea Polyphenols in harmful substance volatilization in reducing smoke of tobacco |
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