CN102061174B - Squalene and tea polyphenol composition and application thereof in cigarettes - Google Patents
Squalene and tea polyphenol composition and application thereof in cigarettes Download PDFInfo
- Publication number
- CN102061174B CN102061174B CN201010529711.XA CN201010529711A CN102061174B CN 102061174 B CN102061174 B CN 102061174B CN 201010529711 A CN201010529711 A CN 201010529711A CN 102061174 B CN102061174 B CN 102061174B
- Authority
- CN
- China
- Prior art keywords
- squalene
- tea
- polyphenol
- composition
- tea polyphenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a squalene and tea polyphenol composition and an application thereof in cigarettes. The composition comprises 0.05-60% of squalene, 0.05-60% of tea polyphenol and the balance of solvent by weight. By the synergic effect of the squalene and the tea polyphenol, the invention achieves the purposes of simultaneously efficiently removing the solid phase free radicals in tar of the cigarettes and the gas phase free radicals in fume, and can obviously reduce the consumption of an antioxidant, thus providing a powerful technical support for solving the problem of smoking and health.
Description
Technical field
The invention belongs to technical field of chemistry, relate to a kind of natural antioxidants composition, be specifically related to the synergistic composition of squalene and two kinds of natural antioxidantss of tea-polyphenol, and the application aspect the gaseous phase free radical in phase Free Radicals and the cigarette smoke in reducing coke tar in cigarette of described composition.
Background technology
Smoking and health are one of main challenges of facing in the process of advancing of tobacco industry.Tobacco industry is just paid attention to smoking and health problem since the seventies, after the eighties especially reducing the objectionable constituent such as tar as Main Topics, carried out many-sided research of technique, now the average releasing content of coke tar of China's cigarette from dropping to more than the 30mg/ in past props up below 16mg/ props up, has obtained major progress.
But the burning of cigarette is except producing thousands of kinds of compounds, also produce the free radical of high density, comprise the phase Free Radicals that the life-span is relatively long, active oxygen radical such as the superoxide anion (O of quinones and half quinones, polycyclic aromatic hydrocarbons free radical and they and oxygen reaction generation
2 -), hydrogen peroxide (H
2O
2), hydroxy radical qiao (OH), singlet oxygen (
1O
2) and the gaseous phase free radical relatively short with lifetime such as lipid peroxidation free radical (ROO), alkoxy free group (RO), alkyl diradical (R), oxynitride free radical etc.And to the health effect the strongest the most harmful be the gaseous phase free radical of cigarette, it can cause tuberculosis, heart trouble and cancer.The crowd of these radical pairs smoker and passive suction " second-hand " cigarette can produce serious injury.
Also few aspect the free radical scavenging research in to flue gas at present, the main injury to human body that reduces free radical the flue gas from adding natural antioxidants, VITAMIN, amino acid, protein etc. and biological enzyme free-radical scavengers and trace element, natural mineral matter.But these free-radical scavengerss generally are one or more simple mixed additive, the ability of antioxidant for clearing free radical has certain selectivity, generally is difficult to long-life phase Free Radicals and the relatively short gaseous phase free radical of lifetime are played scavenging(action) simultaneously.
Squalene is a kind of lipid unsaponifiables, being a kind of many unsaturated olefins (squalene), is to find from the liver oil of shark at first, is named as Squalene in 1914, its chemical name is 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosa carbon, six alkene belong to the open chain triterpene, claim again Squalene, participate in the human body cholesterol biosynthesis and also can enhance metabolism, have superoxide-dismutase (SOD) activity in the body of raising, the enhancing body immunological competence, anti-ageing, antifatigue, the different physiological roles such as antitumor is a kind of avirulent marine bioactivity material with the effect of preventing and curing diseases.Squalene distributes very wide in plant, but content is not high, is lower than 5% of unsaponifiables in the vegetables oil more, and only minority content is more, contains squalene 150～700mg/100g such as sweet oil, and its content is 332mg/100g in the Rice pollard oil.
Tea-polyphenol is the general name of Catechin in Tea class, acetone class, phenolic acids and anthocyan compound.Be a kind of condensed ring aromatic hydrocarbon, can be divided into flavanol compound, hydroxyl-[4]-flavanol compound, anthocyanin class, flavonoid, flavonols and phenolic acids etc.Wherein important with catechin, account for 60%～80% of Polyphenols total amount; Catechin is mainly by several monomer compositions such as EGC, DLC, EC, EGCG, GCG, ECG.The content of tea-polyphenol in tealeaves is generally 20～35%.Take flavanol compound as main, flavanol compound was again take catechins as main during each formed part in tea-polyphenol.The content of catechins accounts for about 70% of tea-polyphenol total amount.Effect with the harmful free radical of very strong elimination, anti-aging effects, radiation resistance, to the restraining effect of cancer cells, antibiotic, germicidal action is to the restraining effect of hiv virus, the existing tea-polyphenol that studies have shown that is also beneficial to the smoker, can clean lung's Nicotine.
At present Relative Angle MF59 and tea-polyphenol be mixed synergy research also seldom, the research that especially is applied to the production of cigarettes aspect there is not yet any technology report.
Summary of the invention
The object of the invention is to overcome the deficiency of free radical scavenging technology in the existing cigarette product, a kind of natural squalene and the tea-polyphenol antioxidant synergistic composition that is mixed is provided.By squalene and tea-polyphenol reasonably are mixed, reach synergistic function between the two, the purpose of realize having complementary advantages, acquisition simultaneously high-efficient cleaning except the natural free-radical scavengers composition of gaseous phase free radical in the phase Free Radicals in the coke tar in cigarette and the flue gas.
Purpose of the present invention is achieved by the following technical programs:
A kind of squalene and tea polyphenol composition are provided, by weight, comprise 0.05～60% squalene, 0.05～60% tea-polyphenol and the solvent of surplus.
Preferably, described squalene and tea polyphenol composition by weight, comprise 0.5～50% squalene, 1～50% tea-polyphenol and the solvent of surplus.
Preferably, the part by weight that described squalene and tea-polyphenol are mixed is 1: 10～10: 1, and more preferably the part by weight that is mixed of squalene and tea-polyphenol is 1: 5～5: 1.
It is 60%～90% aqueous ethanolic solution that described solvent can be selected volume by volume concentration, preferred 70%.
Described squalene can be the extract that from plant, animal or microorganism, extracts or purified after sterling, can adopt commercial product.
Described tea-polyphenol can be that the tea-polyphenol extract that extracts from tealeaves also can be the sterling after purified, can adopt commercial product.
The present invention provides the application of described squalene and tea polyphenol composition simultaneously, is applied to production of cigarettes.
Main application is that described composition is directly added in the cigarette shreds, the phase Free Radicals in the tar that produces during for reducing cigarette burning and the gaseous phase free radical in the cigarette smoke.
Preferably, the ratio of interpolation is the described composition of 0.1～2g: the 100g pipe tobacco.
The invention has the beneficial effects as follows:
1, the present invention's ability of selecting squalene and tea-polyphenol to carry out the removing free radical of the composition that rational mixture obtains improves greatly, obtains obvious synergism, can obviously reduce usage quantity.
2, the present invention adopts the suitable scheme that is mixed, after squalene and tea-polyphenol carried out rational mixture, make squalene and tea-polyphenol bring into play preferably synergistic function, reach high-efficient cleaning simultaneously except the purpose of gaseous phase free radical in phase Free Radicals in the coke tar in cigarette and the flue gas and can obviously reduce the usage quantity of antioxidant, provide strong technical support for solving smoking and healthy problem.
Embodiment
Below in conjunction with further describing the present invention in the implementation.Employed test method is ordinary method if no special instructions among the following embodiment; Employed material, reagent etc. if no special instructions, are reagent and the material that can obtain from commercial channels.
The preparation of embodiment 1 squalene and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 0.05% squalene+1% tea-polyphenol+surplus.
The preparation of embodiment 2 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 0.1% squalene+1% tea-polyphenol+surplus.
The preparation of embodiment 3 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 0.2% squalene+1% tea-polyphenol+surplus.
The preparation of embodiment 4 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 1% squalene+1% tea-polyphenol+surplus.
The preparation of embodiment 5 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 1% squalene+0.05% tea-polyphenol+surplus.
The preparation of embodiment 6 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 1% squalene+0.1% tea-polyphenol+surplus.
The preparation of embodiment 7 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 1% squalene+0.2% tea-polyphenol+surplus.
The preparation of embodiment 8 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, and get final product.
The solvent of 5% squalene+50% tea-polyphenol+surplus.
The preparation of embodiment 9 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, and get final product.
The solvent of 5% squalene+25% tea-polyphenol+surplus.
The preparation of embodiment 10 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 70% aqueous ethanolic solution, and get final product.
The solvent of 5% squalene+5% tea-polyphenol+surplus.
The preparation of embodiment 11 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, and get final product.
The solvent of 25% squalene+5% tea-polyphenol+surplus.
The preparation of embodiment 12 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, and get final product.
The solvent of 50% squalene+5% tea-polyphenol+surplus.
The preparation of embodiment 13 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, and get final product.
The solvent of 30% squalene+60% tea-polyphenol+surplus.
The preparation of embodiment 14 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, and get final product.
The solvent of 30% squalene+45% tea-polyphenol+surplus.
The preparation of embodiment 15 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 80% aqueous ethanolic solution, and get final product.
The solvent of 30% squalene+30% tea-polyphenol+surplus.
The preparation of embodiment 16 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, and get final product.
The solvent of 45% squalene+30% tea-polyphenol+surplus.
The preparation of embodiment 17 squalenes and tea polyphenol composition
According to the following weight ratio a certain amount of squalene and tea-polyphenol being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, and get final product.
The solvent of 60% squalene+30% tea-polyphenol+surplus.
The preparation of embodiment 18 squalene solution
According to the following weight ratio a certain amount of squalene being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 1% squalene+surplus.
The preparation of embodiment 19 squalene solution
According to the following weight ratio a certain amount of squalene being dissolved in volume by volume concentration is in 90% aqueous ethanolic solution, and get final product.
The solvent of 60% squalene+surplus.
The preparation of embodiment 20 tea-polyphenol solution
According to the following weight ratio a certain amount of tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 1% tea-polyphenol+surplus.
The preparation of embodiment 21 tea-polyphenol solution
According to the following weight ratio a certain amount of tea-polyphenol being dissolved in volume by volume concentration is in 60% aqueous ethanolic solution, and get final product.
The solvent of 60% tea-polyphenol+surplus.
Embodiment 22 application experiments
In the production of cigarettes technology for making tobacco threds, program according to flavoring and casing, with being sprayed onto on the pipe tobacco in above-described embodiment 1～21 with being mixed composition and squalene or tea-polyphenol solution continuous uniform, the pipe tobacco that is sprayed with composition, squalene or tea-polyphenol solution being dried in the pipe tobacco water content after between 11%～13%, making cigarette with this area ordinary method again in 10 ℃ cold wind.Per 100 grams are sprayed with composition on the pipe tobaccos and are respectively 0.1,1 and 2 grams, take 70% aqueous ethanolic solution that do not contain squalene or tea-polyphenol as contrast.
Free radical scavenging effect detection in the cigarette smoke: free radical adopts spectrum (ESR) technology to detect in the coke tar in cigarette, smoke gaseous phase free radical detects after adopting spin catching agent PBN (2-benzene tert-butylnitrone) to capture, and the tar phase Free Radicals detects after adopting cambridge filter to capture.
Adopt conventional gaseous phase free radical detection method: adopt glassware to collect the flue gas free radical.Add the carbon tetrachloride solution of certain density free radical scavenger PBN in collector, collector is linked on the smoking machine, take the suction capacity as 35.0mL, suction time is 2s, and suction is spaced apart the standard suction speed smoking cigarette of 60s.Constant volume is collected the flue gas free-atom aqueous solution after the smoking, and it is freezing then to put into liquid nitrogen.Detection volume is 200 μ L.
Phase Free Radicals detection method: after the smoking cambridge filter is taken off, cut out lower 1/10th filter disc and pack into and carry out ESR in the 3mm diameter silica tube and detect.
Produce the content of free radical by detecting the natural antioxidants synergistic composition cigarette that adds different content and different proportionings, compared with the control, calculation composition is to the removing effect of phase Free Radicals in the cigarette smoke and gaseous phase free radical.Experimental result is as follows:
Add 0.1 gram composition to phase Free Radicals in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 1
| Sample | Phase Free Radicals clearance rate (%) | Gaseous phase free radical clearance rate (%) |
| Embodiment 1 | 3.14 | 3.67 |
| Embodiment 2 | 3.62 | 4.01 |
| Embodiment 3 | 3.81 | 4.15 |
| Embodiment 4 | 5.37 | 6.17 |
| Embodiment 5 | 2.38 | 3.07 |
| Embodiment 6 | 2.57 | 3.09 |
| Embodiment 7 | 2.72 | 3.20 |
| Embodiment 8 | 8.51 | 9.32 |
| Embodiment 9 | 6.63 | 8.73 |
| Embodiment 10 | 6.83 | 9.91 |
| Embodiment 11 | 9.39 | 10.27 |
| Embodiment 12 | 10.34 | 11.67 |
| Embodiment 13 | 13.31 | 15.61 |
| Embodiment 14 | 15.42 | 18.91 |
| Embodiment 15 | 14.34 | 17.55 |
| Embodiment 16 | 16.41 | 19.97 |
| Embodiment 17 | 18.53 | 20.64 |
| Embodiment 18 | 0.93 | 2.86 |
| Embodiment 19 | 5.92 | 8.83 |
| Embodiment 20 | 2.67 | 1.02 |
| Embodiment 21 | 7.37 | 3.08 |
Add 1 gram composition to phase Free Radicals in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 2
| Sample | The phase Free Radicals clearance rate | The gaseous phase free radical clearance rate |
| Embodiment 1 | 4.27 | 5.69 |
| Embodiment 2 | 5.61 | 6.37 |
| Embodiment 3 | 6.29 | 7.27 |
| Embodiment 4 | 7.92 | 9.17 |
| Embodiment 5 | 3.17 | 3.92 |
| Embodiment 6 | 3.98 | 5.91 |
| Embodiment 7 | 4.93 | 6.37 |
| Embodiment 8 | 25.67 | 29.59 |
| Embodiment 9 | 21.61 | 23.17 |
| Embodiment 10 | 15.27 | 17.34 |
| Embodiment 11 | 27.64 | 29.61 |
| Embodiment 12 | 31.28 | 35.61 |
| Embodiment 13 | 37.61 | 42.94 |
| Embodiment 14 | 35.67 | 37.19 |
| Embodiment 15 | 32.61 | 35.27 |
| Embodiment 16 | 39.61 | 43.82 |
| Embodiment 17 | 42.29 | 45.61 |
| Embodiment 18 | 1.38 | 4.07 |
| Embodiment 19 | 8.27 | 13.64 |
| Embodiment 20 | 5.01 | 2.82 |
| Embodiment 21 | 12.31 | 6.28 |
Add 2 gram compositions to phase Free Radicals in the flue gas and gas phase free radical scavenging effect in the per 100 gram pipe tobaccos of table 3
| Sample | The phase Free Radicals clearance rate | The gaseous phase free radical clearance rate |
| Embodiment 1 | 6.01 | 7.34 |
| Embodiment 2 | 6.62 | 7.98 |
| Embodiment 3 | 7.24 | 8.37 |
| Embodiment 4 | 10.35 | 12.92 |
| Embodiment 5 | 5.27 | 6.91 |
| Embodiment 6 | 6.31 | 7.24 |
| Embodiment 7 | 7.28 | 9.01 |
| Embodiment 8 | 30.24 | 33.61 |
| Embodiment 9 | 28.33 | 30.17 |
| Embodiment 10 | 23.64 | 26.91 |
| Embodiment 11 | 29.27 | 31.64 |
| Embodiment 12 | 33.67 | 37.29 |
| Embodiment 13 | 38.61 | 43.19 |
| Embodiment 14 | 36.92 | 39.57 |
| Embodiment 15 | 34.67 | 36.92 |
| Embodiment 16 | 40.28 | 45.61 |
| Embodiment 17 | 44.52 | 46.37 |
| Embodiment 18 | 2.67 | 5.32 |
| Embodiment 19 | 9.18 | 14.37 |
| Embodiment 20 | 6.94 | 3.15 |
| Embodiment 21 | 13.18 | 7.08 |
Experiment conclusion: can find out cigarette gaseous phase free radical and phase Free Radicals removing effect from above-described embodiment, when the addition of composition according to 0.1 gram composition: during 100 gram pipe tobacco, it freely has certain removing effect simultaneously to phase Free Radicals and gas phase, particularly work as the proportioning of squalene and tea-polyphenol between 1: 10～10: 1, especially in the time of between 1: 5～5: 1, composition has obvious synergism to solid phase and gas phase free radical scavenging effect.When the addition of composition during at 1 gram/100 gram pipe tobacco, it has obvious removing effect simultaneously to cigarette solid phase and gaseous phase free radical, and work as the weight proportion of squalene and tea-polyphenol between 1: 10～10: 1, especially in the time of between 1: 5～5: 1, composition has obvious synergism to solid phase and gas phase free radical scavenging effect, for single dose, remove effect and improved 3～7 times.When the addition of composition during at 2 grams/100 gram pipe tobacco, for single dose, composition also has obvious synergism to the removing ability of cigarette solid phase and gaseous phase free radical, but for addition was 1 gram/100 gram pipe tobaccos, otherness was not remarkable between the two.Actual according to producing, the present invention is used for the natural antioxidants composition of cigarette, its the removing ability synergism to solid phase and gaseous phase free radical between 1: 10～10: 1 of the proportioning of squalene and tea-polyphenol is obvious, and per 100 gram pipe tobaccos interpolation amount of composition are suitable between 0.1～2 gram.
Claims (8)
1. the application of a squalene and tea polyphenol composition it is characterized in that described squalene and tea polyphenol composition are added in the cigarette shreds phase Free Radicals in the tar that produces during for reducing cigarette burning and the gaseous phase free radical in the cigarette smoke;
Described squalene and tea polyphenol composition are by weight, and comprise 0.05～60% squalene, 0.05～60% tea-polyphenol and the solvent of surplus.
2. the according to claim 1 application of described squalene and tea polyphenol composition is characterized in that described squalene and tea polyphenol composition comprise 0.5～50% squalene, 1～50% tea-polyphenol and the solvent of surplus by weight.
3. the according to claim 1 and 2 application of described squalene and tea polyphenol composition is characterized in that the part by weight that squalene and tea-polyphenol are mixed in described squalene and the tea polyphenol composition is 1: 10～10: 1.
4. the according to claim 3 application of described squalene and tea polyphenol composition is characterized in that the part by weight that squalene and tea-polyphenol are mixed in described squalene and the tea polyphenol composition is 1: 5～5: 1.
5. the according to claim 1 and 2 application of described squalene and tea polyphenol composition, it is characterized in that described squalene for the extract that from plant, animal or microorganism, extracts or purified after sterling.
6. the according to claim 1 and 2 application of described squalene and tea polyphenol composition, it is characterized in that described tea-polyphenol for the tea-polyphenol extract that from tealeaves, extracts or purified after sterling.
7. the according to claim 1 and 2 application of described squalene and tea polyphenol composition is characterized in that described solvent is that volume by volume concentration is 60～90% aqueous ethanolic solutions.
8. the according to claim 1 application of described squalene and tea polyphenol composition it is characterized in that described squalene and tea polyphenol composition are added in the cigarette shreds according to the ratio of 0.1～2g composition/100g pipe tobacco.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010529711.XA CN102061174B (en) | 2010-10-29 | 2010-10-29 | Squalene and tea polyphenol composition and application thereof in cigarettes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010529711.XA CN102061174B (en) | 2010-10-29 | 2010-10-29 | Squalene and tea polyphenol composition and application thereof in cigarettes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102061174A CN102061174A (en) | 2011-05-18 |
| CN102061174B true CN102061174B (en) | 2013-04-24 |
Family
ID=43996682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010529711.XA Expired - Fee Related CN102061174B (en) | 2010-10-29 | 2010-10-29 | Squalene and tea polyphenol composition and application thereof in cigarettes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102061174B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750563A (en) * | 2014-01-15 | 2014-04-30 | 华南农业大学 | Preparation method and radical reduction and harm reduction application of squalene and tea polyphenol composition liquid proliposome |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103767070B (en) * | 2014-01-15 | 2015-08-05 | 中国烟草总公司广东省公司 | The preparation method of squalene and astaxanthin composition liquid precursor liposome and fall base harm reduction and apply |
| CN103815545B (en) * | 2014-01-15 | 2015-09-30 | 华南农业大学 | The preparation method of squalene and tea polyphenol composition multivesicular liposome and fall base harm reduction and apply |
| CN103859588B (en) * | 2014-03-20 | 2016-04-13 | 广西中烟工业有限责任公司 | The preparation of squalene and astaxanthin composition multivesicular liposome and fall base harm reduction |
| CN105154228B (en) * | 2015-06-17 | 2018-07-03 | 湖北中烟工业有限责任公司 | Cigarette is with plant flavone essence cigarette pearl and preparation method thereof |
| CN105154227B (en) * | 2015-06-17 | 2018-07-10 | 湖北中烟工业有限责任公司 | Cigarette plant flavone essence cigarette pearl, preparation method and application |
| CN105738525A (en) * | 2016-02-29 | 2016-07-06 | 中国烟草总公司广东省公司 | High performance liquid chromatographic detection method for squalene contained in tobacco leaves |
| CN105758954A (en) * | 2016-02-29 | 2016-07-13 | 中国烟草总公司广东省公司 | Detecting method for squalene in cigarette smoke |
| CN107890136A (en) * | 2017-11-08 | 2018-04-10 | 江苏瑾辉生物科技有限公司 | Application of the Tea Polyphenols in harmful substance volatilization in reducing smoke of tobacco |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1421232A (en) * | 2002-12-13 | 2003-06-04 | 北京华源生命科贸发展有限公司 | Nutritive health food with functions of reducing blood fat and delaying senility and its prepn process |
-
2010
- 2010-10-29 CN CN201010529711.XA patent/CN102061174B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1421232A (en) * | 2002-12-13 | 2003-06-04 | 北京华源生命科贸发展有限公司 | Nutritive health food with functions of reducing blood fat and delaying senility and its prepn process |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750563A (en) * | 2014-01-15 | 2014-04-30 | 华南农业大学 | Preparation method and radical reduction and harm reduction application of squalene and tea polyphenol composition liquid proliposome |
| CN103750563B (en) * | 2014-01-15 | 2015-08-19 | 华南农业大学 | The preparation method of squalene and tea polyphenol composition liquid precursor liposome and fall base harm reduction and apply |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102061174A (en) | 2011-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102061174B (en) | Squalene and tea polyphenol composition and application thereof in cigarettes | |
| CN102079979B (en) | Composition of squalene and beta-carotene and application thereof in cigarettes | |
| Li et al. | Antioxidant activities of polysaccharides from the fruiting bodies of Zizyphus Jujuba cv. Jinsixiaozao | |
| US10744219B2 (en) | Air freshener composition and preparation method thereof | |
| CN108338406B (en) | Rosemary antioxidant blasting bead and application thereof in cigarette filter stick | |
| Hamsar et al. | Antioxidant activity and the effect of different parts of areca catechu extracts on Glutathione-S-Transferase activity in vitro | |
| Guo et al. | Total phenolic, flavonoid contents and free radical scavenging capacity of extracts from tubers of Stachys affinis | |
| CN104856187A (en) | Safe processing method of high antibacterial and antioxidant activity carya cathayensis shell smoking liquid | |
| CN106665891A (en) | Preparation and use method of snow chrysanthemum polyphenol | |
| Alam et al. | Appraisal of the antioxidant, phenolic compounds concentration, xanthine oxidase and tyrosinase inhibitory activities of Pleurotus salmoneostramineus | |
| CN107362080B (en) | A kind of extracting method of polyphenol in passion fruit pericarp | |
| Murugan et al. | Antioxidant, anti-inflammatory activity, and phytochemical constituents of Ficus (Ficus amplissima Smith) Bark | |
| CN104189936A (en) | Deodorant | |
| CN103815545B (en) | The preparation method of squalene and tea polyphenol composition multivesicular liposome and fall base harm reduction and apply | |
| CN106726867B (en) | Extraction method of linden flower extract and application of extract | |
| CN105087165A (en) | Composite essential oil prepared from taxus cuspidata and coniferous plants and application of composite essential oil | |
| CN105167190A (en) | Finely cut tobacco leaves with flavone essence for cigarettes and method for preparing finely cut tobacco leaves | |
| Campestre et al. | Phenolic compounds and organic acids change in black oxidized table olives | |
| CN101978908B (en) | High-voltage pulse treatment method for reducing loss amount of apple polyphenol in storage process | |
| CN1166324C (en) | Tip filter of cigarette for reducing harmful component in smoke fume | |
| CN103767070B (en) | The preparation method of squalene and astaxanthin composition liquid precursor liposome and fall base harm reduction and apply | |
| CN100512689C (en) | Additive for lowering tar and free radical content in cigarette smoke and its adding method | |
| CN106912556A (en) | A kind of oranges and tangerines adopt rear spacetabs type antisepsis antistaling agent and purposes | |
| CN103750563B (en) | The preparation method of squalene and tea polyphenol composition liquid precursor liposome and fall base harm reduction and apply | |
| CN103859589B (en) | The preparation of a kind of squalene and beta carotene composition liquid precursor liposome and fall base harm reduction |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130424 Termination date: 20211029 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |