CN105029689B - Cigarette flavone compound essence cigarette pearl, preparation method and application - Google Patents
Cigarette flavone compound essence cigarette pearl, preparation method and application Download PDFInfo
- Publication number
- CN105029689B CN105029689B CN201510336900.8A CN201510336900A CN105029689B CN 105029689 B CN105029689 B CN 105029689B CN 201510336900 A CN201510336900 A CN 201510336900A CN 105029689 B CN105029689 B CN 105029689B
- Authority
- CN
- China
- Prior art keywords
- cigarette
- flavone compound
- compound essence
- pearl
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 86
- 229930003944 flavone Natural products 0.000 title claims abstract description 73
- 235000011949 flavones Nutrition 0.000 title claims abstract description 73
- -1 flavone compound Chemical class 0.000 title claims abstract description 70
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 title claims abstract description 65
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims abstract description 16
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000000853 adhesive Substances 0.000 claims abstract description 12
- 230000001070 adhesive effect Effects 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 claims abstract description 8
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims abstract description 8
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims abstract description 8
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 claims abstract description 8
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000005875 quercetin Nutrition 0.000 claims abstract description 8
- 229960001285 quercetin Drugs 0.000 claims abstract description 8
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 claims abstract description 8
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 claims abstract description 8
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000005493 rutin Nutrition 0.000 claims abstract description 8
- 229960004555 rutoside Drugs 0.000 claims abstract description 8
- XDQITMCFPPPMBC-TUANDBMESA-N scutelloside Natural products OC[C@H]1O[C@@H](O[C@@H]2O[C@@H]3C[C@H]4[C@H](O)[C@@H](O)[C@@](O)(CO3)[C@@H]24)[C@H](O)[C@@H](O)[C@@H]1O XDQITMCFPPPMBC-TUANDBMESA-N 0.000 claims abstract description 8
- 239000011122 softwood Substances 0.000 claims description 14
- 241000208125 Nicotiana Species 0.000 claims description 12
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000000835 fiber Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims 1
- 239000003546 flue gas Substances 0.000 abstract description 13
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract description 12
- 239000000463 material Substances 0.000 abstract description 11
- 210000000214 mouth Anatomy 0.000 abstract description 8
- 239000002304 perfume Substances 0.000 abstract description 6
- 230000035807 sensation Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 13
- 230000000391 smoking effect Effects 0.000 description 12
- 206010036790 Productive cough Diseases 0.000 description 9
- 206010011224 Cough Diseases 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 150000002213 flavones Chemical class 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 8
- 210000002345 respiratory system Anatomy 0.000 description 8
- 229930003935 flavonoid Natural products 0.000 description 7
- 235000017173 flavonoids Nutrition 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 6
- 239000010839 body fluid Substances 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 208000024794 sputum Diseases 0.000 description 6
- 210000003802 sputum Anatomy 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 5
- 150000002215 flavonoids Chemical class 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 102000012335 Plasminogen Activator Inhibitor 1 Human genes 0.000 description 3
- 108010022233 Plasminogen Activator Inhibitor 1 Proteins 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 210000000867 larynx Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 210000003296 saliva Anatomy 0.000 description 3
- 238000013456 study Methods 0.000 description 3
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 description 3
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 2
- 210000001552 airway epithelial cell Anatomy 0.000 description 2
- 210000002821 alveolar epithelial cell Anatomy 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010002368 Anger Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- 208000014085 Chronic respiratory disease Diseases 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 1
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 102000004504 Urokinase Plasminogen Activator Receptors Human genes 0.000 description 1
- 108010042352 Urokinase Plasminogen Activator Receptors Proteins 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001088 anti-asthma Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002019 anti-mutation Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000424 bronchial epithelial cell Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 150000002240 furans Chemical class 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 108010071584 oxidized low density lipoprotein Proteins 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 230000005586 smoking cessation Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 210000001779 taste bud Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Abstract
The present invention discloses a kind of cigarette flavone compound essence cigarette pearl, preparation method and application, weigh the adhesive that weight is flavone compound essence weight 0.1%～1%, it is added to after adhesive water dissolves in flavone compound essence, first pass through extruder and be extruded into elongated strip, then it is round as a ball by spheronizator, flavone compound essence cigarette pearl is obtained after being dried；The weight percentages of components of flavone compound essence includes scutelloside 20%～60%, rutin 10%～40%, catechol 10%～40%, Quercetin 10%～40%.Flavone compound essence cigarette pearl has excellent natural breath, brings to cigarette and comfortably smell fragrant sensation, and when cigarette is aspirated, these materials Jing burnings crack out the aroma component that can increase perfume quantity and aroma quality；The active component of flavone compound essence cigarette pearl enters human oral cavity with flue gas in cigarette, can directly act on throat, plays a part of good raising throat comfortableness.
Description
Technical field
The invention belongs to technical field of cigarettes, and in particular to a kind of cigarette flavone compound essence cigarette pearl, preparation method
And application.
Background technology
Natural plants are widely used in tobacco aromaticss, wherein being much containing Flavonoid substances.According to Flavonoid substances
Molecular characterization and interelectric active force power, Primary Study find such material burning cracking after can produce
Furans and its derivative, these materials are the main aroma components in flue gas, can to flue gas bring camerlsed, it is fragrant and sweet,
Roasting perfume, increases perfume quantity and aroma quality.Therefore, in the allotment of essence spice for cigarette, there is the use of many flavonoids perfume materials.
Many researchs also indicate that flavone compound has multiple biological activities, except using its antibacterial, anti-inflammatory, anti-mutation,
The effect such as step-down, clearing heat and detoxicating, calm, diuresis is outer, in anti-oxidant, anticancer, anti-cancer, suppresses the aspects such as lipase also to have significantly effect
Really.It is the scavenger of most of oxygen radicals, thus the vigor of energy increased SOD (superoxide dismutase), reduce MDA (fat
Matter peroxide MDA) and OX-LDL (OxLDL ELISA) generation.It can increase coronary flow, to experiment
Myocardial inyaretion has antagonism；There is protective effect to acute myocardial ischemia；Have to treating coronary heart diseases and angina pectoris, hypertension etc.
Remarkable result；To reducing diastolic pressure, prevent and treat arrhythmia cordis, cardiovascular disease and promoting blood circulation and removing blood stasis also play an important role.
It is chronic respiratory disease, coronary heart disease that substantial amounts of scientific research demonstrates the smog in tobacco from different angles
Etc. the pathogenetic important risk factor of various diseases.Long-term smoker typically has the symptom of cough, abundant expectoration, throat itch, seriously
Affect the quality of life of health and the mankind.Additionally, passive smoking also results in harm to the health of women.In order to mitigate tobacco
Harm of the middle smog to human body, in actively publicity, Smoking is harmful to your health and while advice smoking cessation, also should active development have
The harm reduction cigarette of the effects such as easypro larynx.
Throat is the important component part of respiratory tract, and positioned at tracheae and the confluce of esophagus, and human body pronunciation is important
Organ.When smoker is in smoking, be most vulnerable to harmful substances from flue gases impact is exactly throat.In flue gas, tar is easily retained
In the internal of smoking people, a kind of emplastic is condensed in lung, is attached to the trachea-bronchial epithelial cell and alveolar surface of smoker,
Physics, chemical stimulation are produced, the breathing of human body is affected；Long-time is smoked can reduce the defense function of bottleneck throat mucous membrane, it may appear that
Dry cough, throat's shouting pain etc. are felt, or bring sense of discomfort to throat because smoking causes irascibility excessively prosperous；So smoking for human body is exhaled
The harm for inhaling road, particularly throat is larger, is with the passing of time likely to result in laryngeal pathological process.
A large amount of correlative studys find the organ that respiratory tract stimulates as direct body contact's ambient atmos, are tobacco infringements
The person of being primarily subjected to.And airway epithelial cell resists the first line of defence of environmental stimuli as respiratory tract, suffered harm is particularly tight
Weight.Previously research shows that cigarette stimulates and can adjust alveolar epithelium and bronchiolar epithelium plasma urokinase-type plasminogen activator
(Urokinase type plasminogen activator, uPA), uPAR Research
(urokinase type plasminogen activator receptor, uPAR) system expression changes, alveolar epithelial cells
UPA and uPAR levels raise more notable, presentation uPA advantage states, beneficial to proteolysis.Bronchial epithelial cell is then presented urine
Kinases type PAI-1 (plasminogen activator inhibitor-1, PAI-1) advantage shape
State, is conducive to fibrillatable to be formed.Two kinds of cells are possible to uPA system expressions state difference can be with partial interpretation COPD patient lung qi
The reason for swollen and small airway fibrillatable both different pathologicals change.Separately there are the section of document report lung tissue of rats and smoke from cigarette
Extract is incubated jointly, can increase lung tissue of rats lactic dehydrogenase (lactatec dehydrogenate, LDH) spill and
Nitrite NO2- discharges, and stimulates nitric oxide synthase type (induced nitric oxide synthase, iNOS) living
Property increase, cause injury of lungs.As can be seen here, long-term fume exposure can cause airway epithelial cell form and function damage, from
And the normal physiological function of the upper lower respiratory tract of impact, make smoker produce uncomfortable sensation, or even have a strong impact on life quality
(quality of life, QOF) and life security.The road of reducing tar and reducing harm from consumer's interests are safeguarded, is walked, is Chinese style volume
The developing direction of cigarette.On the premise of consumer's physiology, psychological needs are met, its unfavorable shadow brought to consumer throat is reduced
Ring, lift throat's comfortableness, be tobacco business scientific research personnel's problem demanding prompt solution.
Throat's comfortableness well refer to the smooth exquisiteness of consumer's flue gas for experiencing when product inhale cigarette, oral cavity noresidue,
Nose larynx is non-stimulated, aftertaste has the impressions such as sweet sense.Laryngeal response is concentrated mainly on oral cavity and respiratory system during cigarette smoking
The impression at position, is embodied in drop thorn, resolving sputum, the improvement of the aspect such as promote the production of body fluid, can preferably realize suction comfortableness.
Drop thorn：Excitant refers to impact of the flue gas to sense organ.Being divided into oral stimulation, nasal cavity in impression stimulates and throat's thorn
Swash three kinds.Excitant is big, seemingly has " peppery " taste in oral cavity, can draw tears from sb or shed tears sense in nasal cavity, can make throat in throat
Deflation causes cough.
The excitant of flue gas mainly by acid excessive and alkaline excessive in cigarette and generation, while the water with cigarette
Point, tightness etc. it is also relevant.Peppery thorn is as alkaline matter is on the high side；Thorn of choking is as small molecule shot-like particle is on the high side；Spine (hair
Thorn) it is as acidic materials are on the high side.
Flavone compound has the effect of diastole bronchial smooth muscle, is added in cigarette, can weaken the contracting of flue gas
Pipe is acted on, and alleviates the discomfort that smoke-shock is caused to throat.
Resolving sputum：The people of long-term smoker typically has a certain degree of pharyngitis, and its performance is abundant expectoration and frequency.Having in flue gas
Evil material is frequently gathered in respiratory tract, caused by accelerating the wriggling of villus fiber.
Flavone compound can reduce flue gas life phlegm material, certainly will can reduce heap of the constituents in respiratory system
Product.In addition, flavone compound can speed up tracheae villus fiber wriggling, harmful substance is made quickly to exclude with juice external,
Resolving sputum effect that this just serves to a certain extent.
Promote the production of body fluid：Tianjin is saliva, promote the production of body fluid be exactly make oral cavity in secret out of saliva.Modern medicine is it also holds that containing many in saliva
Helpful body composition is planted, promoting the production of body fluid in mouth, it is easypro suitable to quench one's thirst.
Various flavone compounds have nourishing Yin and promoting production of body fluid, and moistening lung is relieved inflammation or internal heat, effect of Heat Diabetes.It is added in cigarette, can
Stimulate oral cavity taste bud and there is effect of promoting the production of body fluid, flue gas is more mellow and fuller, with sweet sense is returned, reduces withered sense.
Much contain Flavonoid substances in tobacco aromaticss, but for be specifically designed for improving throat's comfortableness, with cough-relieving,
Resolving sputum, the composition of effect of relievining asthma have not been reported, and need for further study.
The cigarette pearl containing essence and flavoring agent is put in filter tip in prior art, the cigarette pearl can make cigarette in aspiration procedure
In more raw fragrant, reinforcing fragrance or characteristic, make smoker obtain more comfortable experience.This cigarette pearl can only simply make cigarette
It is raw fragrant in aspiration procedure, it is impossible to play cough-relieving, resolving sputum, effect of relievining asthma.
The content of the invention
For the deficiencies in the prior art, the present invention provides a kind of cigarette flavonoids with cough-relieving, resolving sputum, effect of relievining asthma
Compound essence cigarette pearl, preparation method and application, cigarette flavone compound essence cigarette pearl are added in pipe tobacco, in cigarette smoking mistake
Cheng Zhong, plays its excellent anti-inflammatory, sharp larynx effect, so as to improve throat's comfortableness of cigarette smoking, improves cigarette smoking quality.
The present invention solves the technical scheme that adopted of above-mentioned technical problem：A kind of cigarette flavone compound essence is provided
The preparation method of cigarette pearl, the preparation method are as follows：
The adhesive that weight is flavone compound essence weight 0.1%～1% is weighed, is added after adhesive water dissolves
To in flavone compound essence, stir and make softwood, then by extrusion-spheronizator on softwood, first pass through extruder and squeeze
Into elongated strip, then round as a ball by spheronizator, it is 1.2g/ that particle size range is obtained after being dried for 0.5mm～4mm, heap density
The flavone compound essence cigarette pearl of ml～1.8g/ml；
Wherein：The weight percentages of components of the flavone compound essence is as follows：
Further, the DNA purity of the scutelloside, rutin, catechol and Quercetin is 80～95%.
Further, described adhesive is PVP, hydroxypropyl cellulose, hydroxypropyl methyl cellulose and carboxymethyl cellulose
One or more in element.
Further, the particle size range of the cigarette pearl is 0.8mm～1.5mm, and heap density is 1.4g/ml～1.6g/ml.
Further, the drying is dried 4～6 hours under the conditions of temperature is for 60 DEG C～80 DEG C.
A kind of cigarette is method system described above with flavone compound essence cigarette pearl, the flavone compound essence cigarette pearl
Standby flavone compound essence cigarette pearl.
A kind of application of cigarette with flavone compound essence cigarette pearl, by flavone compound essence cigarette pearl by weight percentage
0.1～5.0：100 be added to pipe tobacco in make cigarette, the flavone compound essence cigarette pearl is prepared by method described above
Flavone compound essence cigarette pearl.
The present invention has advantages below：
1st, flavone compound essence cigarette pearl of the invention has excellent natural breath, brings to cigarette and comfortably smell perfume (or spice)
Feel, when cigarette is aspirated, these materials Jing burnings crack out the aroma component that can increase perfume quantity and aroma quality, further carry
Cigarette smoking quality is risen；
2nd, the active component of flavone compound essence cigarette pearl of the invention enters human oral cavity with flue gas in cigarette, can
To directly act on throat, play a part of good raising throat comfortableness；
3rd, flavone compound essence cigarette pearl of the present invention is added in pipe tobacco, does not increase any production process, simply
It is easy, be conducive to industrial-scale production；
4th, flavone compound flavor of raw material wide material sources of the present invention, with low cost, easy to utilize.
Specific embodiment
In order that the objects, technical solutions and advantages of the present invention become more apparent, with reference to embodiments, to the present invention
It is further elaborated.Specific embodiment described herein only to explain the present invention, is not used to limit this
It is bright.
Embodiment 1
Flavone compound essence is mixed according to ratio in table 1, weight is weighed for flavone compound essence weight
0.1% hydroxypropyl methyl cellulose adhesive, with being added to after 400ml water dissolves in flavone compound essence, stirring is equal
It is even to make softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then by spheronizator
It is round as a ball, upper fluid bed obtain particle diameter after being to be dried 6 hours under the conditions of 60 DEG C in temperature for 0.5mm, heap density for 1.8g/ml Huang
Ketone compounds essence cigarette pearl.
Table 1
| Flavones species | Scutelloside | Rutin | Catechol | Quercetin |
| Percentage by weight | 20% | 10% | 30% | 40% |
Embodiment 2
Flavone compound essence is mixed according to ratio in table 2, weight is weighed for flavone compound essence weight
0.5% hydroxypropyl methyl cellulose adhesive, with being added to after 450ml water dissolves in flavone compound essence, stirring is equal
It is even to make softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then by spheronizator
Round as a ball, it is 1.6g/ml that upper fluid bed obtains particle diameter for 0.8mm, heap density after being to be dried 5.5 hours under the conditions of 65 DEG C in temperature
Flavone compound essence cigarette pearl.
Table 2
| Flavones species | Scutelloside | Rutin | Catechol | Quercetin |
| Percentage by weight | 30% | 20% | 20% | 30% |
Embodiment 3
Flavone compound essence is mixed according to ratio in table 3, weight is weighed for flavone compound essence weight
0.8% carboxymethyl cellulose binder, with being added in flavone compound essence after 500ml water dissolves, the system of stirring
Into softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then rolled by spheronizator
Circle, upper fluid bed obtain particle diameter after being to be dried 6 hours under the conditions of 70 DEG C in temperature for 1.0mm, heap density for 1.6g/ml flavones
Class compound essence cigarette pearl.
Table 3
| Flavones species | Scutelloside | Rutin | Catechol | Quercetin |
| Percentage by weight | 40% | 30% | 10% | 20% |
Embodiment 4
Flavone compound essence is mixed according to ratio in table 4, weight is weighed for flavone compound essence weight
0.8% carboxymethyl cellulose binder, with being added in flavone compound essence after 500ml water dissolves, the system of stirring
Into softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into elongated strip, then rolled by spheronizator
Circle, upper fluid bed obtain particle diameter after being to be dried 6 hours under the conditions of 75 DEG C in temperature for 1.5mm, heap density for 1.4g/ml flavones
Class compound essence cigarette pearl.
Table 4
| Flavones species | Scutelloside | Rutin | Catechol | Quercetin |
| Percentage by weight | 50% | 30% | 10% | 10% |
Embodiment 5
Flavone compound essence is mixed according to ratio in table 5, weight is weighed for flavone compound essence weight 1%
Hydroxypropyl cellulose adhesive, with being added in flavone compound essence after 550ml water dissolves, stirring, it is soft to make
Material, then by extrusion-spheronizator on softwood, first passes through extruder and is extruded into elongated strip, then round as a ball by spheronizator, on
Fluid bed obtain particle diameter after being to be dried 5 hours under the conditions of 70 DEG C in temperature for 1.5mm, heap density for 1.4g/ml flavonoids
Compound essence cigarette pearl.
Table 5
| Flavones species | Scutelloside | Rutin | Catechol | Quercetin |
| Percentage by weight | 60% | 10% | 20% | 10% |
Embodiment 6
Flavone compound essence is mixed according to ratio in table 6, weight is weighed for flavone compound essence weight 1%
Hydroxypropyl cellulose adhesive, with being added in flavone compound essence after 550ml water dissolves, stirring, it is soft to make
Material, then by extrusion-spheronizator on softwood, first passes through extruder and is extruded into elongated strip, then round as a ball by spheronizator, on
Fluid bed obtain particle diameter after being to be dried 4 hours under the conditions of 80 DEG C in temperature for 1.5mm, heap density for 1.4g/ml flavonoids
Compound essence cigarette pearl.
Table 6
| Flavones species | Glycyrrhizin | Eugenol | Cyanidenon | Aurantiin |
| Percentage by weight | 25% | 25% | 40% | 10% |
For caused by smoking " cough, abundant expectoration, pant " three big symptoms, with reference to classical respiratory tract antibechic, eliminating the phlegm, relieving asthma
Pharmacodynamic evaluation method on the basis of, from various different living models screening set up exhale suitable for natural plant extracts
The method for inhaling pipe protection effect assessment, evaluates the phenol red excretion method of antitussive effect, mouse using ammonia induced cough in mice and evaluates eliminating the phlegm
Effect, Guinea pig isolated trachea spiral strip method evaluate antiasthmatic effect.
By more than, flavone compound essence cigarette pearl prepared in 6 embodiments is added in pipe tobacco, then to making
Cigarette carry out detection of exhaust gas compositions, and carry out phenol reduced rate and compare, be specifically shown in table 7 below
Table 7
*P<0.05,**P<0.01 is compared with equal number blank cigarette group
By more than, flavone compound essence cigarette pearl prepared in 6 embodiments is added in pipe tobacco, then to making
Cigarette carry out sensory evaluation, as a result such as table 8
Table 8
The above, the only specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, any
Belong to those skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in all are answered
It is included within the scope of the present invention.Therefore, protection scope of the present invention should be defined by scope of the claims.
Claims (4)
1. preparation method of a kind of cigarette with flavone compound essence cigarette pearl, it is characterised in that：The preparation method is as follows：
The adhesive that weight is flavone compound essence weight 0.1%～1% is weighed, after adhesive water dissolves, Huang is added to
In ketone compounds essence, stir and make softwood, then by extrusion-spheronizator on softwood, first pass through extruder and be extruded into carefully
Long strip, it is then round as a ball by spheronizator, be dried after obtain particle size range for 0.5mm～4mm, heap density be 1.2g/ml～
The flavone compound essence cigarette pearl of 1.8g/ml；Described adhesive is PVP, hydroxypropyl cellulose, hydroxypropyl methyl fiber
One or more in element and carboxymethylcellulose calcium；
Wherein：The weight percentages of components of the flavone compound essence is as follows：
The DNA purity of the scutelloside, rutin, catechol and Quercetin is 80～95%；The drying be temperature be 60
DEG C～80 DEG C under the conditions of be dried 4～6 hours.
2. preparation method of the cigarette according to claim 1 with flavone compound essence cigarette pearl, it is characterised in that：The cigarette
The particle size range of pearl is 0.8mm～1.5mm, and heap density is 1.4g/ml～1.6g/ml.
3. a kind of cigarette is with flavone compound essence cigarette pearl, it is characterised in that：The flavone compound essence cigarette pearl is right
Require flavone compound essence cigarette pearl prepared by 1 methods described.
4. application of a kind of cigarette with flavone compound essence cigarette pearl, it is characterised in that：Flavone compound essence cigarette pearl is pressed
Percentage by weight 0.1～5.0：100 be added to pipe tobacco in make cigarette, the flavone compound essence cigarette pearl is claim
Flavone compound essence cigarette pearl prepared by 1 methods described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510336900.8A CN105029689B (en) | 2015-06-17 | 2015-06-17 | Cigarette flavone compound essence cigarette pearl, preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510336900.8A CN105029689B (en) | 2015-06-17 | 2015-06-17 | Cigarette flavone compound essence cigarette pearl, preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105029689A CN105029689A (en) | 2015-11-11 |
| CN105029689B true CN105029689B (en) | 2017-03-29 |
Family
ID=54437128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510336900.8A Active CN105029689B (en) | 2015-06-17 | 2015-06-17 | Cigarette flavone compound essence cigarette pearl, preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105029689B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110353298A (en) * | 2019-08-30 | 2019-10-22 | 深圳雾芯科技有限公司 | Electronic cigarette liquid |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330016A (en) * | 2018-11-14 | 2019-02-15 | 河南中烟工业有限责任公司 | A kind of Exocarpium Citri Grandis medicinal extract, preparation method and the application in cigarette |
| CN111748410A (en) * | 2020-07-01 | 2020-10-09 | 云南绅博源生物科技有限公司 | Sweet essence for adding to tobacco and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1980163A1 (en) * | 2007-04-10 | 2008-10-15 | Litesso-Anstalt | Method for treating tobacco leaves and tobacco leaves and their utilisation |
| CN101974367B (en) * | 2009-06-23 | 2012-12-12 | 湖北中烟工业有限责任公司 | Novel flavor-enhancing and harm-reducing natural spice for tobacco and use thereof |
| CN103689802B (en) * | 2013-12-03 | 2015-04-08 | 红云红河烟草(集团)有限责任公司 | Tobacco porous particle and application thereof in cigarette |
| CN104366687B (en) * | 2014-09-15 | 2016-03-16 | 云南中烟新材料科技有限公司 | A kind of low temperature does not burn cigarette sucked material and preparation method thereof |
-
2015
- 2015-06-17 CN CN201510336900.8A patent/CN105029689B/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110353298A (en) * | 2019-08-30 | 2019-10-22 | 深圳雾芯科技有限公司 | Electronic cigarette liquid |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105029689A (en) | 2015-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104905405B (en) | The cigarette of the essence containing plant flavone mouth stick preparation method and application | |
| CN105146736B (en) | Health-care cigarette and preparation method thereof | |
| CN105029689B (en) | Cigarette flavone compound essence cigarette pearl, preparation method and application | |
| CN105154227B (en) | Cigarette plant flavone essence cigarette pearl, preparation method and application | |
| CN107874317B (en) | Agalloch eaglewood cigarette additive and preparation method thereof, application method and the agalloch eaglewood cigarette containing cigarette additive | |
| CN105167177B (en) | Cigarette flavones essence cigarette pearl, preparation method and application | |
| CN101011184A (en) | Tobacco substitution chrysanthemum health cigarette | |
| CN104905406B (en) | The cigarette of the essence containing flavone compound mouth stick preparation method and application | |
| CN105011369B (en) | The cigarette of the essence containing flavones mouth stick preparation method and application | |
| CN104544556A (en) | Aquilaria agallocha cigarette making method and Aquilaria agallocha cigarette product thereof | |
| CN104547682B (en) | A kind of composition of effect of relievining asthma that wet one's whistle with removing heat from the lung and relieving sorethroat | |
| CN109043641A (en) | The cigarette and its manufacture craft of eaglewood leaf and linaloe oil mixing | |
| CN108113049A (en) | A kind of herbal tea flavored liquids essence, microcapsule essence and its application in cigarette | |
| CN103549651A (en) | Toxicity attenuation cigarette with anti-cough effect | |
| CN103040098B (en) | Lavender odor type snuff | |
| CN103054169B (en) | Snuff with ginger flower odor | |
| CN109998151A (en) | Medium chain triglyceride is improving and/or is reducing the application in respiratory tract | |
| CN107568785A (en) | A kind of health care cigarette that can be used for smoking cessation and preparation method thereof | |
| CN103054163B (en) | Lily-flavored snuff | |
| CN103040104B (en) | Cananga odorata odor type snuff | |
| CN1981649A (en) | Lucid ganoderma cigarette and its production | |
| CN1391848A (en) | Poisonless cigarette | |
| CN101125026A (en) | Green cigarette | |
| CN1235524C (en) | Cigarette for nasal health and its making method | |
| CN103919273B (en) | A kind of Chinese honey locust type snuff |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |