CN101692931A - Low-harm cigarette containing mogroside and preparation method thereof - Google Patents
Low-harm cigarette containing mogroside and preparation method thereof Download PDFInfo
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- CN101692931A CN101692931A CN200910189843A CN200910189843A CN101692931A CN 101692931 A CN101692931 A CN 101692931A CN 200910189843 A CN200910189843 A CN 200910189843A CN 200910189843 A CN200910189843 A CN 200910189843A CN 101692931 A CN101692931 A CN 101692931A
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Abstract
The invention discloses a low-harm cigarette containing mogroside and a preparation method thereof, aiming at solving the technical problem of reducing the hazard of cigarettes. The low-harm cigarette containing the mogroside has the tobacco shred containing the mogroside with the mass of 0.0001-3% of that of the tobacco shred. The preparation method of the cigarette containing the mogroside comprises the following steps: adding 0.1-10g of the mogroside into 50-100ml of alcohol with the concentration of 10-100%; spraying the mogroside onto the tobacco shred according to the proportion that the wolfberry polysaccharide accounts for 0.0001-3% of the tobacco shred; and finally, naturally drying and making into the cigarettes according to the conventional cigarette technology. Compared with the prior art, as the tobacco shred contains the ingredient of mogroside which can enters the human body along with the main stream smoke and is absorbed by the human body through blood circulation, thus playing the role of eliminating phlegm, relieving cough, clearing away free radical, resisting oxidation, strengthening the immunity, resisting tumour and protecting the liver; furthermore, the smoke of the cigarettes is mellow and faint scent, can clean the oral cavity and prevent decayed teeth, and reduces the hazard to the human health.
Description
Technical field
The present invention relates to a kind of cigarette and preparation method thereof, particularly a kind of low-harmful cigarette and preparation method thereof.
Background technology
Tobacco serious harm health causes respiratory system, cardio-cerebrovascular, digestive system, neural disease.The people that inhale 15 to 20 cigarettes an every day easily suffers from lung cancer, and the probability that its carcinoma of mouth or laryngocarcinoma cause death is than 14 times in National People's Congress of non-smoking.The cigarette of enfleuraging is to cause chronic bronchitis and emophysematous main cause, and chronic lung disease itself, has also increased to suffer from an inflammation of the lungs and cardiopathic danger.Smoking has catastrophe risk to the women, and premature labor and underweight easily takes place smoking pregnant woman's fetus, and the infantile period immunologic function reduces, and is liable to illness.China in 2002 more than 15 years old crowd's smoking rate be 35.8%, wherein the masculinity and femininity smoking rate is respectively 66.0% and 3.1%.And China's smoking population has the trend of rejuvenation, compares with the eighties in 20th century, and the mean age of beginning smoking was reduced to 19.7 years old by 22.4 years old.China is tobacco big producing country, also is tobacco consumption big country.The tobacco production of China is equivalent to the summation of other 7 maximum tobacco producing countries.The annual cigarette of selling of China is up to 1.6 trillion, and the cigarette of state's human consumption accounts for the world 1/3rd, and it is very great for the healthy harmonious development meaning that promotes the Chinese tobacco industry to carry out tobacco harm reduction and health research.So far, people have done a large amount of work, the report of existing a plurality of reduction cigarette harm, compound method as Chinese patent application number 93105146.0 disclosed cigarette Chinese herbal medicine natural additive compound wilted melon GL solutions, with the made cigarette of this liquid, zoopery is shown with tangible cough-relieving, reduces phlegm, antiasthmatic effect, has no side effect, clinical trial smoker remission rate reaches 95%, and the harmful effect of microcirculation of nail rugae only is 1/3～1/4 of contrast cigarette.Compare with the existing method that reduces harmfulness of smoking, effect is strong, wide ranges, and environmental pollution is little, cost is low, cigarette does not have flavour of a drug.Chinese patent application number 200810155168.4 disclosed a kind of cigarettes are used herbal composite, said composition is made by following bulk drugs material: glossy ganoderma 25-35 part, genseng 2-4 part, flower of Panax ginseng 8-12 part, cloves 10-20 part, agalloch eaglewood 8-12 part, dried orange peel 3-7 part, Radix Glycyrrhizae 1-3 part, activated carbon 10-15 part, peppermint 8-12 part, lemon 1-3 part, during smoking at the cigarette combustion position sticking get the said composition powder or the said composition powder sneaked into make cigarette in the pipe tobacco, tar and nicotine soakage in the time of can effectively reducing smoking, and the oral cavity of can sterilizing, the clearing profit is made an uproar, change oral peculiar smell, also can purify of the influence of harmful components such as pungent pungent peculiar smell in the cigarette surrounding environment.Chinese patent application number 200610032218.0 disclosed a kind of cigarette and manufacture methods thereof that contain Chinese herb feed additive, it is to be raw material with the red sage root, moutan bark, balloonflower root, rheum officinale, fritillaria thunbergii, different qualities according to every flavor Chinese herbal medicine, after purifying with different extraction solvents and method respectively, in proportion with essence and spices preparation, add in the pipe tobacco, make cigarette.However, the low-harmful cigarette of prior art still can not satisfy the needs of the generation of the various diseases that may cause when the prevention smoker smokes, and also will further utilize the new industrial research new product.
Summary of the invention
The purpose of this invention is to provide a kind of low-harm cigarette that contains mogroside and preparation method thereof, the technical problem that solve is to reduce the harm of cigarette.
The present invention is by the following technical solutions: contain the low-harm cigarette of mogroside, have pipe tobacco, contain the mogroside that accounts for tobacco quality 0.0001～3% in the described pipe tobacco.
Mogroside of the present invention is a mogroside monomeric compound active component.
Mogroside of the present invention is to be the Momordica grosvenori plant extracts that significant composition accounts for oeverall quality 0.1 to 99% with the mogroside monomeric compound.
Contain the mogroside that accounts for tobacco quality 0.01% in the pipe tobacco of the present invention.
Contain the mogroside that accounts for tobacco quality 0.1% in the pipe tobacco of the present invention.
Contain the mogroside that accounts for tobacco quality 0.5% in the pipe tobacco of the present invention.
A kind of preparation method who contains the low-harm cigarette of mogroside, may further comprise the steps: 50 to 100 milliliters of ethanol that mogroside 0.1 to 10 gram added 10 to 100% concentration, account for 0.0001～3% of tobacco quality by mogroside, be sprayed on the pipe tobacco, naturally dry, make cigarette with conventional cigarette process then.
Method mogroside of the present invention is a mogroside monomeric compound active component.
Method mogroside of the present invention is to be significant composition, to account for the Momordica grosvenori plant extracts of oeverall quality 0.1 to 99% with the mogroside monomeric compound.
The present invention compared with prior art, contain mogroside in the pipe tobacco or be the plant extracts of active component or significant composition with the mogroside, fat-soluble good, in smoking process, can enter human body with main flume, be absorbed by the body by blood circulation, thereby bring into play that it eliminates the phlegm, antibechic, removing free radical, anti-oxidant, strengthen effect immune, antitumor, that protect the liver, smoke alcohol and delicate fragrance, can reduce the harm of cigarette, but oral cavity cleaning simultaneously, preventing decayed tooth, thereby reduce the harm of flue gas to human body.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.The low-harm cigarette that contains mogroside of the present invention contains the mogroside that accounts for tobacco quality 0.0001～3% in the pipe tobacco.Mogroside is to be active component with the mogroside monomeric compound, or is the Momordica grosvenori plant extracts that significant composition accounts for oeverall quality 0.1 to 99% with the mogroside monomeric compound.The molecular formula of mogroside monomeric compound: C
60H
102O
29, structural formula is: (
The sweet ingredient that mogroside contains is C
60H
102O
292H
2The triterpenes glycosides combination that O links to each other with 5～6 glucose.With mogroside monomeric compound 0.1 to 10 gram, add concentration and be 50 to 100 milliliters of 10 to 100% ethanol, evenly be sprayed on the pipe tobacco, or be the mogroside monomeric compound plant extracts 0.1 to 10 gram of significant composition, content 0.1 to 99%, add the ethanol 50 to 100 of 10 to 100% concentration, evenly be sprayed on the pipe tobacco, mogroside accounts for tobacco quality 0.0001～3%, naturally dry, make cigarette with conventional cigarette process then.
Mogroside is a buff powder, and the arhat fruital is arranged, and it is extremely sweet to distinguish the flavor of, and sugariness is 240 times of sucrose, 197～201 ℃ of fusing points (decomposition).Stable to photo-thermal, soluble in water and ethanol.Mogroside is added in the cigarette, to reduce the harm of cigarette, make can eliminate the phlegm, antibechic, removing free radical, anti-oxidant, strengthen immune, antitumor, protect the liver, the low harm cigarette of fresh breath, make the smoker in smoking, can suck effective medicinal ingredient mogroside, thereby be of value to health.
Mogroside is one of main active of China's traditional Chinese medicine Momordica grosvenori, have eliminate the phlegm, antibechic, removing free radical, anti-oxidant, strengthen effect immune, antitumor, that protect the liver.Wherein noticeable be eliminate the phlegm, antibechic, antitumor action.The main pharmacological of mogroside comprises: 1, antitussive effect, the mogroside of purity＞98% is irritated stomach, ammonia spraying drawn cough mouse antitussive effect is all arranged, when dosage reached 160mg/kg and 320mg/kg, it showed tangible antitussive effect and is dose-dependence.The mogroside of purity 50% effect of obvious minimizing cough number of times is arranged, and 8.0g/kg dosage is to SO to the mouse cough that concentrated ammonia liquor brings out
2Cause the effect that significant prolongation is arranged incubation period of mouse cough.Total glycosides＞80% mogroside 0.2g/kg, 0.4g/kg, the mouse cough that 0.8g/kg dosage brings out ammoniacal liquor all have obvious minimizing mouse cough number of times.2, phlegm-dispelling functions, the mogroside of purity＞98% is irritated stomach, can obviously increase the phenol red excretion amount of mouse tracheae, and be dose-dependence; After mogroside adds frog esophagus 0.5h with the concentration of 20mg/ml, can obviously strengthen its ciliated cell's motion.The mogroside of purity 50% significantly increases the phenol red excretion amount of mouse tracheae, also significantly increases rat expectoration amount (capillary glass-tube method).3, strengthening the immunization mogroside gives normal and endoxan CTX inhibition mouse stomach, normal immune function of mice there is not obvious effect, but can significantly improve the macrophage phagocytic function of CTX immunosuppressed mice and the proliferation function of T cell, show that mogroside has certain positive control to the cellular immune function of CTX immunosuppressed mice.4, cancer suppressing action is an initiator with DMBA, and TPA is a carcinogenic promoting agent, carries out mouse skin two-stage carcinogenicity testing; Mogroside (mogroside V) to delay carcinogenesis identical with stevioside glycosides or than stronger, show that it has the anti-promoting effect.5, remove free radical and antioxidation activity, the mogroside extract all has certain scavenging action to hydroxyl radical free radical and ultra-oxygen anion free radical, and along with the increase of mogroside extract concentrations, remove effect and strengthen gradually, be certain dose-effect relationship; The mogroside extract has remarkable inhibitory action to the oxidation hemolytic reaction in the external incubation process of rat RBC, the mogroside extract during to rat red blood cell autoxidation haemolysis MDA generate stronger inhibitory action arranged; The mogroside extract has good inhibitory effect to the spontaneous MDA that generates of rat liver homogenate.Inhibition best results during with concentration 0.875mg/ml reaches 23.63%; The mogroside extract can suppress the lipid peroxidation of liver tissues of rats, and the hepatic tissue peroxide injury that Fe and H202 are induced has protective effect, can reduce the generation of erythrocyte hemolysis; The mogroside extract can significantly suppress hepatic mitochondria MDA and generate, and its inhibiting rate increases with the increase of concentration.6, to the influence of blood sugar, mogroside 0.1g/kg, the 0.2g/kg of total glycosides＞80%, 0.4g/kg dosage had not both had to reduce the blood glucose value that the diabetic mice that also do not raise has raise to the diabetic mice model; 0.4g/kg the high dose mogroside does not have the blood glucose value of remarkable rising normal mouse.Disposable oral 30% mogroside 200mg/kg does not have obvious influence to the blood-sugar content and the liver enzyme activity of health adult.Mogroside 150mg/kg, 300rng/kg dosage irritate stomach, though mouse amount of drinking water, blood sugar level do not return to normally, compare all significantly reduction with the type 1 diabetes mouse that the alloxan modeling becomes.
With mogroside is that the plant extracts of active component or significant composition adds in the pipe tobacco, the burning velocity of starting to exchange fire of cigarette is moderate, utilize cigarette in the suction combustion process, to have the more and more lower thermograde of temperature between from the combustion head to the filter tip like this, the active ingredient mogroside was not just volatilized with main flume before also being destroyed by high temperature together and be inhaled into human body, bring into play its pharmacological action, thereby reach low evil effect.Mogroside low-harm cigarette of the present invention adds smoke alcohol and delicate fragrance behind the mogroside in pipe tobacco, not only do not influence original mouthfeel of cigarette, and sweet sensation is arranged after the suction.
In order to confirm that thereby the active ingredient mogroside in the pipe tobacco can enter human body with the flue gas volatilization, the applicant adopts liquid chromatogram, and promptly the analytical method of HPLC detects flue gas.With cigarette sample balance 48h, get 15 of cigarette, on smoking machine,, collect TPM with filter disc by the standard conditions suction.Filter disc and 100mL methyl alcohol are added in the triangular flask, behind the supersonic oscillations 30min, filter then, repeat once, merging filtrate is concentrated to 1mL, adds 95% ethanol dissolving, shifts, is settled in the 10mL volumetric flask, gets 1mL and carries out Instrumental Analysis.
Take by weighing the pipe tobacco of the present invention that is equivalent to 15 weight of cigarette again and put into triangular flask, add 100mL methyl alcohol, behind the supersonic oscillations 30min, filter, repeat to add methyl alcohol 100mL supersonic oscillations 30min again after, filter, merging filtrate, be concentrated to 1mL, add 95% ethanol dissolving, transfer, constant volume are in the 10mL volumetric flask.Get this solution of 1mL and carry out Instrumental Analysis.
The HPLC analysis condition:
1, Novapak C18 chromatographic column (150.0mm * 4.6mm, 5 μ m), methyl alcohol: water: phosphoric acid (27: 73: 0.1) is the phase that flows, and flow velocity is 1.0ml/min; , 25 ℃ of column temperatures, retention time is 9.56min
2, Hyper ODS2C18 post (250.0mm * 4.6mm, 5 μ m), acetonitrile: water: acetic acid (10: 90: 0.1) is the phase that flows, and flow velocity is 1.0ml/min, 35 ℃ of column temperatures
3, shimpack CLC (150mmX4.6mm, 5 μ m), methyl alcohol-0.05% phosphoric acid (55: 45), flow velocity are 1.0ml/min, detect wavelength 292nm, 25 ℃ of column temperatures
4. chromatographic column: Luna C185 μ m 4.6 * 150mm
Phase flows: methanol-water-glacial acetic acid (50: 50: 1) flow velocity: 1mL/min
Detect wavelength: 275nm column temperature: 30 ℃ of sensitivity: 0.01AUFS sample size: 10 μ L
Test result shows: added the mogroside monomeric compound, or be that the cigarette of plant extracts of active component or significant composition is in burning with the mogroside, it is respectively 0.0001%, 3% o'clock that mogroside accounts for tobacco quality, be dispersed with 30%, 45% mogroside active ingredient in the flue gas respectively, and fragrance is plentiful pure and mild.
Embodiment 1, get Fructus Monordicae extract 1 gram of Guilin Laiyin Biotechnology Co., Ltd., the mogroside monomeric compound accounts for extract oeverall quality 50%, concentration is 100 milliliters of dissolvings of ethanol of 75%, accounting for 0.01% of tobacco quality by mogroside then evenly is sprayed on the common pipe tobacco, naturally dry, make cigarette with conventional cigarette process again.
Embodiment 2, get Fructus Monordicae extract 1 gram of Guilin Laiyin Biotechnology Co., Ltd., the mogroside monomeric compound accounts for extract oeverall quality 80%, concentration is 100 milliliters of dissolvings of ethanol of 50%, accounting for 0.1% of tobacco quality by mogroside then evenly is sprayed on the common pipe tobacco, naturally dry, make cigarette with conventional cigarette process again.
Embodiment 3, get Momordica grosvenori meal 100 grams of Guilin Laiyin Biotechnology Co., Ltd., 3000 milliliters of backflows of ethanol with 50%, filtrate decompression under 0.05Mpa, 80 ℃, 2 hours conditions is condensed into flowing soaking paste, the extract that must contain mogroside, the mogroside monomeric compound accounts for extract oeverall quality 80%, with this extract 1 gram with 50 milliliters of dissolvings of ethanol of 50%, accounting for 0.5% of tobacco quality by the extract of mogroside evenly is sprayed on the common pipe tobacco, naturally dry, make cigarette with conventional cigarette process again.
The present invention is that the amount that the plant extracts of active component or significant composition joins in the pipe tobacco has no particular limits to the mogroside monomeric compound or with the mogroside, mouthfeel when mainly looking smoking decides, it adds quality and can be 0.0001% of pipe tobacco, is up to 3%.And mogroside monomeric compound or be that the plant extracts of active component or significant composition can adopt the method for any known to prepare with the mogroside.
Claims (9)
1. contain the low-harm cigarette of mogroside, have pipe tobacco, it is characterized in that: contain the mogroside that accounts for tobacco quality 0.0001～3% in the described pipe tobacco.
2. the low-harm cigarette that contains mogroside according to claim 1 is characterized in that: described mogroside is a mogroside monomeric compound active component.
3. the low-harm cigarette that contains mogroside according to claim 1 is characterized in that: described mogroside is to be the Momordica grosvenori plant extracts that significant composition accounts for oeverall quality 0.1 to 99% with the mogroside monomeric compound.
4. the low-harm cigarette that contains mogroside according to claim 1 is characterized in that: contain the mogroside that accounts for tobacco quality 0.01% in the described pipe tobacco.
5. the low-harm cigarette that contains mogroside according to claim 1 is characterized in that: contain the mogroside that accounts for tobacco quality 0.1% in the described pipe tobacco.
6. the low-harm cigarette that contains mogroside according to claim 1 is characterized in that: contain the mogroside that accounts for tobacco quality 0.5% in the described pipe tobacco.
7. preparation method who contains the low-harm cigarette of mogroside, may further comprise the steps: 50 to 100 milliliters of ethanol that mogroside 0.1 to 10 gram added 10 to 100% concentration, account for 0.0001～3% of tobacco quality by mogroside, be sprayed on the pipe tobacco, naturally dry, make cigarette with conventional cigarette process then.
8. the preparation method who contains the low-harm cigarette of mogroside according to claim 7 is characterized in that: described mogroside is a mogroside monomeric compound active component.
9. the preparation method who contains the low-harm cigarette of mogroside according to claim 7 is characterized in that: described mogroside is to be significant composition, to account for the Momordica grosvenori plant extracts of oeverall quality 0.1 to 99% with the mogroside monomeric compound.
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| CN200910189843A CN101692931A (en) | 2009-09-01 | 2009-09-01 | Low-harm cigarette containing mogroside and preparation method thereof |
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| CN200910189843A CN101692931A (en) | 2009-09-01 | 2009-09-01 | Low-harm cigarette containing mogroside and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102960856A (en) * | 2012-12-10 | 2013-03-13 | 红塔烟草(集团)有限责任公司 | Salty-reducing additive for tobaccos, and preparation method and application of salty-reducing additive |
| CN104762132A (en) * | 2015-03-05 | 2015-07-08 | 云南中烟工业有限责任公司 | Preparation method and application of Siraitia grosvenorii extract |
| CN104939319A (en) * | 2014-09-09 | 2015-09-30 | 邱芳龙 | Atomizing combination capable of replacing cigarettes |
| CN108523221A (en) * | 2018-06-29 | 2018-09-14 | 郑州轻工业学院 | A kind of cigarette composite filter and preparation method thereof prepared by grosvenor momordica leaf |
| CN115444163A (en) * | 2022-09-26 | 2022-12-09 | 广西中烟工业有限责任公司 | Oriented use method of fruit sweet essence based on ester spice smoke transfer behavior |
-
2009
- 2009-09-01 CN CN200910189843A patent/CN101692931A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102960856A (en) * | 2012-12-10 | 2013-03-13 | 红塔烟草(集团)有限责任公司 | Salty-reducing additive for tobaccos, and preparation method and application of salty-reducing additive |
| CN104939319A (en) * | 2014-09-09 | 2015-09-30 | 邱芳龙 | Atomizing combination capable of replacing cigarettes |
| CN104762132A (en) * | 2015-03-05 | 2015-07-08 | 云南中烟工业有限责任公司 | Preparation method and application of Siraitia grosvenorii extract |
| CN108523221A (en) * | 2018-06-29 | 2018-09-14 | 郑州轻工业学院 | A kind of cigarette composite filter and preparation method thereof prepared by grosvenor momordica leaf |
| CN115444163A (en) * | 2022-09-26 | 2022-12-09 | 广西中烟工业有限责任公司 | Oriented use method of fruit sweet essence based on ester spice smoke transfer behavior |
| CN115444163B (en) * | 2022-09-26 | 2023-09-08 | 广西中烟工业有限责任公司 | Directional use method of fruit sweet essence based on smoke transfer behavior of ester spice |
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Application publication date: 20100414 |