CN1234307C - Harm reducing agent made from Chinese herbal medicines for cigarettes - Google Patents

Abstract

The present invention relates to a harm reducing agent made of Chinese herbal medicine, which is used for cigarettes. The active components of the Chinese herbal medicine with an edible function and a medical function are selected and extracted as the harm reducing agent, such as 5 to 25 % of perilla, 15 to 35 % of astragalus root, 20 to 45 % of root of straight ladybell, and 20 to 25 % of honeysuckle. The Chinese herbal medicine is evenly attached to tobacco shreds which are used for producing cigarettes. The harm reducing agent does not influence the smoking quality of sense organs, and has obvious health care function for a respiratory tract of a consumer.

Description

A kind of cigarette Chinese herbal medicine harm-reducing agent

One, technical field

The present invention relates to a kind of cigarette additive, exactly is a kind of cigarette Chinese herbal medicine harm-reducing agent.

Two, background technology

It is the common issue that cigarette industry faces that evil falls in attenuation.What have at present adds reconstituted tobacoo in cigarette composition, though can reduce the burst size of tar and other oxious components, sensory evaluating smoking's fragrance deficiency, lightly seasoned, strength is little, excitant is big.What have chews adsorbents such as adding silica gel, active carbon in the rod, though held back tar and CO, has also held back the fragrant composition that causes in the flue gas simultaneously, influences cigarette flavor style and flue gas feature, if the adsorbent particle diameter is too small, is easily sucked the oral cavity by the consumer in addition.

Three, summary of the invention

Thinking of the present invention is to select the Chinese herbal medicine of some kinds of medicine-food two-purposes (compound Chinese herb) to obtain its extract (effective ingredient) as harm-reducing agent through extraction, and this harm-reducing agent evenly attached on the pipe tobacco, is processed cigarette product with this pipe tobacco.This harm-reducing agent and pipe tobacco have compatible preferably, do not influence the cigarette organoleptic quality, and can effectively reduce the damaging action of smoker's respiratory system.

Described Chinese herbal medicine is made up of and percentage by weight following:

Purple perilla 5～25%

The Radix Astragali 15～35%

The root of straight ladybell 20～45%

Honeysuckle 20～45%

Preferably:

Purple perilla 10～20%

The Radix Astragali 20～30%

The root of straight ladybell 25～40%

Honeysuckle 25～40%

Extract its effective ingredient with known method behind the said herbal medicine prescription, such as, diacolation, heating decoction or backflow etc. under the normal temperature.

Effective ingredient in the Chinese herbal medicine has water miscible (using water as solvent extraction), and fat-soluble (doing solvent extraction with 80% ethanol) arranged.As the cigarette harm-reducing agent, both all can, become separately to use, or mix and use.Experimental results show that water miscible harm-reducing agent and tobacco aroma compatibility are more better, no drug smell.The following test comprises all uses water-soluble harm-reducing agent by animal experiment.

Adding method directly is sprayed onto extract on the pipe tobacco equably, dry then precipitation, and this method is simple.Extract precipitation, evaporate to dryness are contained thing admittedly, also are feasible on the pipe tobacco with containing admittedly that thing evenly is attached to.The addition of harm-reducing agent, to contain thing admittedly, every kilogram of pipe tobacco adds 0.6～1.0g.

Add harm-reducing agent and do not add harm-reducing agent cigarette product sensory evaluating smoking quality as follows:

Sample	Fragrance	Harmony	Assorted gas	Excitant	Pleasant impression	Add up to
							The trial-production contrast	31.91 32.00	5.00 5.07	14.00 13.87	14.07 13.57	16.92 16.73	81.90 81.24

Sensory evaluating smoking's difference in quality is little generally, adds harm-reducing agent and does not have negative effect.

Provide the initiatively smoking of examination mouse with spray pattern, every mouse every day twice, each 1 cigarette, smoking is 30 days continuously.Comparative test result is as follows:

1, to the influence of the phenol red discharge rate in mouse breathing road:

Group	Dosage (g/kg/d)	Method of administration	Number of animals (n)	Phenol red discharge rate (mg/l)
					The all precious cigarette of NS control group+NS group	20.0ml 20.0ml	Aerosol sucks aerosol and sucks	10 10	0.200±0.017 0.226±0.032

The all precious cigarette+medicine of all precious cigarette+medicine of all precious cigarette+medicine

20.00 6.80 2.27

Aerosol sucks aerosol and sucks the aerosol suction

10 10 10

0.285±0.039 0.247±0.033 0.235±0.029

Each smoking group all can increase the phenol red discharge rate in mouse breathing road, and the harm-reducing agent high dose group increases obviously.

2, to the influence of mice serum tissue SOD and MDA:

Group	Dosage (g/kg/d)	Number of animals (n)	SOD(U/mgprot)	MDA(nmol/ml)
					The all precious cigarette of the NS control group+all precious cigarette+medicine of the NS group all precious cigarette+medicine of all precious cigarette+medicine	20.0ml 20.0ml 20.00 6.80 2.27	8 7 8 8 8	329.65±78.74 146.57±54.63 285.59±71.59 262.14±24.34 261.01±66.55	21.36±3.22 34.13±2.8 23.07±4.58 25.00±5.17 26.70±2.38

3, to the influence of mouse lung tissue SOD and MDA

Group	Dosage (g/kg/d)	Number of animals (n)	SOD(U/mgprot)	MDA(nmol/ml)
					The all precious cigarette of the NS control group+all precious cigarette+medicine of the NS group all precious cigarette+medicine of all precious cigarette+medicine	20.0ml 20.0ml 20.00 6.80 2.27	8 7 8 8 8	115.50±33.94 68.64±8.79 89.93±16.21 85.81±17.52 82.00±9.46	16.36±2.90 25.89±6.41 17.60±2.91 18.88±3.23 19.97±5.01

Compare with precious group, of cigarettes all, SOD obviously raises in high, medium and low dosage group mice serum and the lung tissue, illustrates that this harm-reducing agent has certain antioxidation.

4, the pathological research to mouse shows, smoking has tangible influence to respiratory system, and it is more mainly to show as in the respiratory tract goblet cell, in the macrophage more tiny black particle shape material is arranged in the alveolar space.But add the harm-reducing agent group, goblet cell and black granule number obviously subtract, and illustrating has protective effect to respiratory system.

5, the inflammatory factor to mouse studies show that, smoking matter interleukins B, immune antiboidy IgA content improve, and can obviously reduce inflammatory factor interleukins B but add the harm-reducing agent group.

Four, the specific embodiment

Be solvent with water now, non-limiting examples is described below:

1, gets 5 parts of purple perillas (calling A in the following text), 35 parts of the Radixs Astragali (calling B in the following text), 20 parts of the root of straight ladybell (calling C in the following text), 40 parts of honeysuckles (calling D in the following text), the decocting that adds 2～5 times of amounts after the mixing boils or refluxed 1～3 hour, isolated by filtration, filter residue extracting in water more once merges filtrate twice, concentrates, or dehydration, evaporate to dryness contained thing admittedly, and be standby.

2, get A25 part, B15 part, C40 part, D20 part, operation is with embodiment 1.

3, get A10 part, B30 part, C25 part, D35 part, operation is with embodiment 1.

4, get A20 part, B20 part, C40 part, C20 part, operation is with example 1.

5, get A15 part, B25 part, C30 part, D30 part, operation is with embodiment 1.

6, get embodiment 1～5 resulting harm-reducing agent concentrate and evenly be sprayed on the pipe tobacco by the dosage that per kilogram pipe tobacco interpolation 0.6～1g contains thing admittedly, dry again, this pipe tobacco processing cigarette product.

7, get embodiment 1～5 resulting harm-reducing agent and contain thing admittedly, the dosage of pressing embodiment 6 is evenly attached on the pipe tobacco.This pipe tobacco processing cigarette product.

Claims (3)

1, a kind of cigarette Chinese herbal medicine harm-reducing agent is characterized in that: add the compound Chinese herb extract in pipe tobacco, described compound Chinese herb has following component and percentage by weight:

Purple perilla 5～25%

The Radix Astragali 15～35%

The root of straight ladybell 20～45%

Honeysuckle 20～45%

2, harm-reducing agent according to claim 1 is characterized in that: the preferred following percentage by weight of compound Chinese herb:

Purple perilla 10～20%

The Radix Astragali 20～30%

The root of straight ladybell 25～40%

Honeysuckle 25～40%

3, harm-reducing agent according to claim 1 and 2 is characterized in that: described compound Chinese herb extract can be that aqueous extract or aqueous extract consolidating behind dehydration, evaporate to dryness contain thing; Also can be that ethanol extract consolidating behind precipitation, evaporate to dryness contains thing.