CN108272072A - Anti-fog haze health food or drug and preparation method thereof - Google Patents
Anti-fog haze health food or drug and preparation method thereof Download PDFInfo
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- CN108272072A CN108272072A CN201711294398.4A CN201711294398A CN108272072A CN 108272072 A CN108272072 A CN 108272072A CN 201711294398 A CN201711294398 A CN 201711294398A CN 108272072 A CN108272072 A CN 108272072A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to health food or field of pharmaceutical technology, provide a kind of anti-fog haze health food or drug, the health food or drug are using broccoli seed extractive as main active component, one or more active constituents for being also aided in black fungus extract, dried tremella extract and yeast beta glucan.The anti-fog haze health food or drug of the present invention can be oral food, electuary, oral solution or chewable tablets, it can help body lead discharging, reduce influence of the haze to body, the symptoms such as red dry throat, cough, expectoration are swallowed in control caused by haze weather, immunity of organism can also be adjusted simultaneously, and pre- preventing tumor occurs.In addition, the present invention also provides the preparation methods of above-mentioned electuary, oral solution or chewable tablets, broccoli seed extractive, black fungus extract, dried tremella extract and yeast beta glucan are weighed according to quantity as effective ingredient, punching is prepared according to field of health care food conventional method addition auxiliary material, preparation method is simple.
Description
Technical field
The present invention relates to health food or health medicine field, it is related to a kind of anti-fog haze health food or drug and its preparation
Method.
Background technology
The constituent of haze is very numerous and jumbled, containing a large amount of poisonous and hazardous Atmospheric Chemistry particulate matters, wherein to health
Play the particulate matter (PM) that the mainly diameter significantly endangered is less than 10 microns.The coarseparticulate that 2.5 microns to 10 microns of grain size
From airborne dust, dust storm etc.；2.5 microns of fine particles (abbreviation PM2.5) below are then essentially from burning (such as machine of fossil fuel
Motor-car tail gas, fire coal), volatile organic matter, including heavy metal lead, hydrogen sulfide etc..Grain size is between 2.5 microns to 10 microns
Particulate matter can be inhaled into, but part can be excreted by the Mucosa Barrier protective effect of the bodies such as sputum, in addition also there is portion
Branch is obstructed by the cilium in intranasal portion, relatively small to human health damage；And grain size is in 2.5 microns of fine particles below
That is PM2.5 is not easy to be blocked, these particles exhale an energy-absorbing to be directly entered and are adhered to human respiratory tract and lung by the one of people
In bubble, cause the illnesss such as acute rhinitis, airway hyperreactivity and acute bronchitis.For bronchial asthma, chronic bronchial
Chronic respiratory disease patients, the haze such as scorching, obstructive emphysema and Chronic Obstructive Pulmonary Disease can make state of an illness acute attack
Or progressive aggravates.
In addition, haze weather pollutants in air is more, air pressure is low, gently then causes that people are uncomfortable in chest, blood pressure increases, heavy then be easy
Induce the acute attack of angiocardiopathy.Haze can also influence sunshine, because the characteristic of aerosol can enhance the activity of infectious disease, and
And also affect mental health.
Currently, on the one hand country actively promotes a conservation culture, making great efforts to improve environment, pollution administration；On the other hand, it studies
Persons have also discovered the ability that Partial Food has the anti-fog haze ability of enhancing body, adjusts immunity of organism.
Invention content
The purpose of the present invention is to provide a kind of anti-fog haze health food or health medicines, and the purpose of the present invention, which is lain also in, to be carried
For providing the preparation method of the anti-fog haze health food or health medicine.
The first aspect of the present invention provides a kind of anti-fog haze health food or drug, based on broccoli seed extractive
Want active component.
In addition, in anti-fog haze health food provided by the invention or drug, active component further include black fungus extract,
It is one or more in dried tremella extract and yeast-beta glucan.
Some researches show that with certain in terms of anti-fog haze for anti-fog haze health food or drug according to the present invention
Effect, specific effect are as follows：
The main health-care components of broccoli seed extractive are two kinds of ingredients of sulforaphen and glucorphanin, and America and Japan Europe etc. is multinational
Clinical test it is in progress.Wherein there are two clinical researches to be completed in China, is related to lung cancer prevention (anti-fog haze), 2 phases faced
Bed (NCT 01437501), conclusion are：The broccoli sprout beverage containing glucorphanin, sulforaphen is taken, benzene can be promoted (carcinogenic
Object) excretion rate raising 61%, methacrylaldehyde (lung irritant) improves 23%, it is proposed that broccoli of the supplement containing glucorphanin, sulforaphen
Product suffers from risk to reduce the cancer caused by atmospheric haze pollutant.
Black fungus has the function of nourishing, moisturize, blood-nourishing benefit stomach, promoting blood circulation and hemostasis, moistening lung, ease constipation.The plant being rich in agaric
Object collagen component has stronger suction-operated.Dust, the impurity etc. of human body can will be entered because breathing by taking black fungus extract
Pollutant, which is concentrated, to be adsorbed and excretes, to achieve the purpose that wash stomach only, support lung qi clearing lung-heat pipe；It also has dissolving simultaneously
The effect of impurity and purification blood, is natural dust catcher in blood.
White fungus since ancient times, is widely used in beauty, protects on lung.Chinese medicine thinks that it enters lung, stomach, kidney three and passes through, can enriching yin
Heat-clearing moistens the lung and relieve the cough, nourishing the stomach to improve the production of body fluid, and QI invigorating and blood have well freckle, dry skin, xeropulmonary cough, cough with lung heat
Effect.Modern pharmacology is tested, it was also found that the polysaccharose substance in white fungus has fine effect to promoting immunity, resisting tumour.
The polysaccharide that the active structure of yeast-beta glucan is made of glucose unit, it can activated macrophage,
The immunocytes such as neutrophil cell stimulate body comprehensively to improve interleukin, the basic element of cell division and the content of distinct antibodies
Immune system.Many experiments show that beta glucan can promote the generation of internal IgM antibody, improve humoral immunity, cell is exempted from
Epidemic disease power.In addition, beta glucan, which also has, removes free radical, radioresistance, dissolving cholesterol, prevents hyperlipidemia and resist filtration venereal disease
The effects that being infected caused by poison, fungi, bacterium.
Further, in anti-fog haze health food or drug provided by the invention, each component and its weight percent are：
Each component preferred weight percent is：
In above-mentioned formula, include but not limited to according to the different addible auxiliary materials of dosage form made：Oligofructose, resistance paste
Essence, konjaku flour, instant mangosteen powder, D-mannital, lactose, maltodextrin, mangosteen powder, magnesium stearate, water etc..Add sieve
Chinese fruit powder, moistening lung drop is dry, as auxiliary material, can also play the effect for adjusting food mouthfeel；Addition lactose etc. can play ease constipation
Defaecation, the effect for adjusting intestinal flora；Oligofructose, D-mannital etc. can adjust mouthfeel as a kind of sweetener；Resistance
Dextrin is a kind of low molecule water-soluble dietary fiber；Konjaku flour is a kind of insoluble diedairy fiber；Maltodextrin is a kind of starch,
For the supporting body in tablet；Magnesium stearate is mainly used as antiplastering aid, and manufactured particle is made to have good mobility and can press
Property.
Further, in anti-fog haze health food or drug provided by the invention, health food is oral food；Drug is punching
Agent, oral solution or chewable tablets.
The second aspect of the present invention is, provides the preparation method of anti-fog haze health food or drug：Western orchid is weighed according to quantity
Seeds of flowering plants seed extract, black fungus extract, dried tremella extract and yeast-beta glucan are led as effective ingredient according to health food
Domain conventional method addition auxiliary material prepares electuary, oral solution or chewable tablets.
The electuary preparation method of the anti-fog haze of compound broccoli seed extractive of the present invention is (by mass percentage) as follows：
Auxiliary material：It is (insoluble including oligofructose (sweetener), resistant dextrin (low molecule water-soluble dietary fiber), konjaku flour
Property fiber), instant mangosteen powder (seasoning) 71.2%.
Mixing powdered agent is made by this prescription, is taken after being dissolved in water.
The preparation method of the anti-fog haze tablet of compound broccoli seed extractive of the present invention is (by mass percentage) as follows：
Auxiliary material (D-mannital, lactose, maltodextrin, mangosteen powder, magnesium stearate) 69%
Tablet is made by this prescription tabletting, chewable tablets can be used as, or swallow with water.
The preparation method of the anti-fog haze oral solution of compound broccoli seed extractive of the present invention is (by mass percentage) as follows：
Auxiliary material (D-mannital, lactose, maltodextrin, mangosteen powder, sorbic acid, purified water) 67%
Oral administration solution is made by this prescription tabletting, warm water can be contained and taken.
Broccoli seed extractive, black fungus extract, dried tremella extract, yeast-beta glucan in the present invention are powder
Shape.
Broccoli seed extractive is bought from Ke Naiou trades (Shanghai) Co., Ltd., also can be from U.S. Brassica public affairs
It is bought in department, Shanghai Re Chuan Industrial Co., Ltd.s.Purchase when with contained in broccoli seed extractive sulforaphen and trailing plants
The content for foretelling sulphur glycosides is used as purchase standard not less than 13%.
Yeast-beta glucan can be bought from Ke Naiou trades (Shanghai) Co., Ltd..
Black fungus extract, dried tremella extract can be bought from Lv You Food Co., Ltd of Beijing.
The present invention is combined a variety of anti-haze food extracts having been approved, white fungus, agaric, broccoli seed
It is the food of integration of drinking and medicinal herbs class, yeast-beta glucan is one kind, and there is immunoregulatory food, Multiple components combination to overcome
The deficiency of one-component enhances the effect of anti-haze.Meanwhile during pulvis, oral solution, chewable tablets make, addition mangosteen powder is made
For auxiliary material, moistening lung drop is dry, can also play the effect for adjusting food mouthfeel, and addition lactose etc., which can play, to relax bowel, adjusts
The effect of intestinal flora.
Food additives, clear can be added in the formula of the anti-fog haze of compound broccoli seed extractive proposed by the present invention
Cool dose etc., adjust stability and appearance color, mouthfeel of finished product etc..
Beneficial effects of the present invention are as follows：
1, of the invention using broccoli seed extractive as anti-fog haze electuary, oral solution and the chewable tablets of main active
It can help body lead discharging, reduce influence of the haze to body, red dry throat, cough, expectoration are swallowed in control caused by haze weather
Etc. symptoms, while immunity of organism can also be adjusted, pre- preventing tumor occurs.
2, white fungus, agaric, the broccoli seed that the present invention selects are the food of integration of drinking and medicinal herbs class, and source is sufficient, are eaten
It is with a long history, thus with broccoli seed extractive, black fungus extract, dried tremella extract and yeast-beta glucan be activity at
The anti-fog haze health food prepared or drug is divided not to have toxic side effect, the human body suitable for various constitutions, various age brackets is taken.
Specific implementation mode
For a further understanding of the present invention, the present invention is described in further detail with reference to embodiment, but is answered
Work as understanding, these descriptions are only the feature and advantage further illustrated the present invention, rather than to the limit of the claims in the present invention
System.
Following embodiments are to more clearly explain and introduce the present invention, it is not limited to the preferred forms,
And present disclosure and protection domain are not construed as limiting.Anyone under the inspiration of the present invention or by the present invention and its
His prior art be combined and output it is any with the present invention it is same or similar as product, belong to the present invention protection model
Within enclosing.
Specific experiment step or condition person are not specified in embodiment, according to routine experiment described in document in the art
The operation of step or condition can carry out.Reagents or instruments used without specified manufacturer, being can be by acquisition purchased in market
Conventional reagent product.
The anti-fog haze electuary prescription of 1 compound broccoli seed extractive of embodiment and preparation
A kind of electuary prescription of the anti-fog haze of compound broccoli seed extractive：Black fungus extract powder 0.6g, white fungus extraction
Object powder 0.6g, broccoli seed extractive powder 0.115g, yeast-beta glucan 0.125g, oligofructose (sweetener), resistance paste
Smart (low molecule water-soluble dietary fiber), konjaku flour (insoluble fibre), instant mangosteen powder (seasoning) amount to 3.56g.Electuary
Often it is packaged as 5g.
Preparation flow：Raw material, which is sieved, --- weighs --- mixing softwood processed --- granulation drying --- whole grain is always mixed --- point
Dress --- packaging.
The anti-fog haze tablet formulation of 2 compound broccoli seed extractive of embodiment and preparation
A kind of formula of the tablet of the anti-fog haze of compound broccoli seed extractive：Broccoli seed extractive powder 100mg, ferment
Mother-beta glucan 80mg, black fungus extract powder 3mg, dried tremella extract powder 3mg, auxiliary material (D-mannital, lactose, malt paste
Essence, mangosteen powder, magnesium stearate) 414mg, every gross weight 600mg.
Preparation method：Raw material, which is sieved, --- weighs --- mixing softwood processed --- granulation drying --- whole grain --- pressure
Piece --- packaging.
The anti-fog haze tablet formulation of 3 compound broccoli seed extractive of embodiment and preparation
A kind of formula of the anti-fog haze oral solution of compound broccoli seed extractive：Black fungus extract powder 10g, white fungus extraction
Object powder 10g, broccoli seed extractive powder 15g, yeast-beta glucan 10g, auxiliary material (D-mannital, lactose, mangosteen powder,
Sorbic acid, distilled water) 15g, amount to 60ml.
Preparation method：It weighs and --- prepares --- embedding --- gland --- labeling --- mounted box.
4 animal experiment of embodiment
The influence i.e. lead-dispelling effect that formula to probe into the present invention expels heavy metal in haze, researcher carry out
One group of zoopery.
1, grouping and lead poisoning model modeling：Wistar rats 20, half male and half female, weight 180-220g are cured by naval
Zoopery section of institute provides, and is normally raised with complete feed, is divided into control group (10) and experimental group (10).Two groups of rats
It contaminates lead to model 1 month, freely be drunk with the lead acetate (being prepared by deionized water) of 0.5g/L.
2, experimentation：The electuary for preparing the anti-fog haze of compound broccoli seed extractive that rat takes, will by embodiment 1
5g electuaries are dissolved in 10mL water, consider the dose lonvestion of rat and human body, take 0.1mL be diluted to mL be used as to the concentration taken and
Dosage.Every mouse of experimental group is given the electuary for the anti-fog haze of compound broccoli seed extractive for taking aforementioned preparation by irrigation stomach device
The mixed liquor of comparable sodium is made by irrigation stomach device to taking mL/d by starch in mL/d, control group.Before experiment starts, two groups of rats point
Not carry out foundation level blood lead measure.After being administered 1 month by above-mentioned experimental program, the measurement of Pb-B is carried out again.Number
According to processing：Data indicate that the t that obtained result is carried out to RANDOMIZED BLOCK DESIGN is examined, and the results are shown in Table 1 with x ± S.
3, experimental result：
Table 1 tests blood lead concentration variation in rat body
Two groups of blood lead variation P ＜ 0.05.
4, conclusion：The anti-fog haze formula of compound broccoli seed extractive provided by the invention can play the work of lead discharging toxin expelling
With protecting body in haze, reduce influence of the lead poisoning to each system of human body.
5 trial population of embodiment
400 citizen volunteers are recruited in Shijiazhuang City of Hebei Province and are divided into 4 groups, wherein 3 groups are continuously taken the present invention respectively
Anti-fog haze food in embodiment 1-3, including electuary, chewable tablets, oral solution one month, another group is blank control group.Experiment
As a result:It was tested by one week, eats the volunteer of the anti-fog haze food of compound broccoli seed extractive prepared by embodiment 1-3 not
There are the symptoms such as apparent cough, abundant expectoration, uncomfortable in chest, and there is apparent cough in the volunteer for not eating any anti-haze product of clearing lung-heat
Cough, abundant expectoration, the symptoms such as uncomfortable in chest, change environment or it is simple see a doctor after its symptom be eased.In the embodiment of the present invention 1 to 3
Anti-fog haze beverage is respectively 76.3%, 74.9% and 75.1% to the effective percentage for preventing or alleviating symptom caused by haze, as a result
It shows that the anti-fog haze food of compound broccoli seed extractive of the present invention has symptom caused by haze to alleviate well and prevent
Effect.
The made anti-fog haze food of compound broccoli seed extractive of the present invention, is main with a variety of natural plant extracts
Ingredient, it is safe and harmless, it cooperates with anti-haze, improve immunity of organisms, long-term drinking can be that human body resists PM2.5, heavy metal and enhancing
Immunity provides new support.
The preferred embodiment of the invention is illustrated above, but the invention be not limited to it is described
Embodiment, those skilled in the art can also make various equivalent under the premise of without prejudice to the invention spirit
Modification or replacement, these equivalent modifications or replacement are all contained in the application claim limited range.
Claims (8)
1. a kind of anti-fog haze health food or drug, which is characterized in that using broccoli seed extractive as main active component.
2. anti-fog haze health food according to claim 1 or drug, which is characterized in that active component further includes black fungus
It is one or more in extract, dried tremella extract and yeast-beta glucan.
3. anti-fog haze health food according to claim 1 or drug, which is characterized in that the anti-fog haze health food or
Each component and its weight percent are in drug：
Surplus is auxiliary material.
4. anti-fog haze health food according to claim 1 or drug, which is characterized in that the anti-fog haze health food or
Each component and its weight percent are in drug：
5. anti-fog haze health food according to claim 3 or 4 or drug, which is characterized in that the auxiliary material is oligomeric fruit
Sugar, resistant dextrin, konjaku flour, mangosteen powder, D-mannital, lactose, maltodextrin, magnesium stearate it is one or two kinds of with
On.
6. anti-fog haze health food according to claim 1 or drug, which is characterized in that the health food is oral food
Product.
7. anti-fog haze health food according to claim 1 or drug, which is characterized in that the drug is electuary, takes orally
Liquid or chewable tablets.
8. the preparation method of the anti-fog haze health food or drug described in claim 3 or 4, which is characterized in that weigh institute according to quantity
Broccoli seed extractive, black fungus extract, dried tremella extract and yeast-beta glucan are stated as effective ingredient, according to health care
Field of food conventional method addition auxiliary material prepares electuary, oral solution or chewable tablets.
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| CN116114819A (en) * | 2022-12-01 | 2023-05-16 | 中华全国供销合作总社济南果品研究所 | Black fungus composite solid beverage and preparation method thereof |
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Application publication date: 20180713 |