CN107173805A - It is a kind of that there is the health food for preventing and treating lung cancer function - Google Patents
It is a kind of that there is the health food for preventing and treating lung cancer function Download PDFInfo
- Publication number
- CN107173805A CN107173805A CN201710390458.6A CN201710390458A CN107173805A CN 107173805 A CN107173805 A CN 107173805A CN 201710390458 A CN201710390458 A CN 201710390458A CN 107173805 A CN107173805 A CN 107173805A
- Authority
- CN
- China
- Prior art keywords
- lung cancer
- selenium
- health food
- preventing
- cancer function
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims abstract description 35
- 201000005202 lung cancer Diseases 0.000 title claims abstract description 32
- 208000020816 lung neoplasm Diseases 0.000 title claims abstract description 32
- 235000013402 health food Nutrition 0.000 title claims abstract description 20
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 claims abstract description 47
- 235000017647 Brassica oleracea var italica Nutrition 0.000 claims abstract description 47
- 239000011669 selenium Substances 0.000 claims abstract description 42
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 38
- 239000000284 extract Substances 0.000 claims abstract description 36
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 35
- UFLHIIWVXFIJGU-ARJAWSKDSA-N (Z)-hex-3-en-1-ol Chemical compound CC\C=C/CCO UFLHIIWVXFIJGU-ARJAWSKDSA-N 0.000 claims abstract description 17
- 125000003748 selenium group Chemical group *[Se]* 0.000 claims abstract description 3
- 240000003259 Brassica oleracea var. botrytis Species 0.000 claims abstract 7
- 244000308180 Brassica oleracea var. italica Species 0.000 claims description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- 239000007910 chewable tablet Substances 0.000 claims description 4
- 235000009508 confectionery Nutrition 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 10
- 238000002360 preparation method Methods 0.000 abstract description 5
- 238000003556 assay Methods 0.000 abstract description 2
- 238000000338 in vitro Methods 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 description 19
- 239000000243 solution Substances 0.000 description 10
- 239000000469 ethanolic extract Substances 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 238000000605 extraction Methods 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 3
- 201000005296 lung carcinoma Diseases 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000000259 anti-tumor effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- -1 sulphur compound Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Prepared the invention discloses selenium-rich broccoli leaf-alcohol extract with the purposes in preventing and treating the health food of lung cancer function, the invention also discloses a kind of health food for having and preventing and treating lung cancer function, its active component is selenium-rich broccoli leaf-alcohol extract.Cell assay in vitro result shows that selenium-rich broccoli leaf-alcohol extract has stronger inhibitory action to the propagation of human lung cancer cell A549, therefore available for health product of the preparation with anti-lung cancer function.
Description
Technical field
The invention belongs to field of health care food, and in particular to selenium-rich broccoli leaf-alcohol extract has in preparation prevents and treats lung cancer
Purposes in the health food of function, has the health food for preventing and treating lung cancer function the invention further relates to a kind of.
Background technology
, the cancer report display of IARC of World Health Organization issue in 2010：Global lung cancer new cases
About 1,610,000, malignant tumour is accounted for respectively and newly sends out ratio and the 13% of death and 18% by dead about 1,380,000,
First is occupy in malignant tumour.The environmental pollution that industrial boom is brought is increasingly serious, and the ratio of number of smokers is not yet
Disconnected increase, causes the incidence and mortality of lung cancer constantly to raise, situation is extremely severe, therefore in the urgent need to developing new treatment
Means tackle this problem with anticancer drugs.
Since broccoli is introduced from last century from Europe, cultivated area at home constantly increases, and has been daily life now
The vegetables being loved by people in work.Broccoli nutritive value is very high, contains abundant protein, carbohydrate, vitamin C, dimension life
Many functional components beneficial to health such as plain A.Broccoli, which not only has, is rich in sulphur compound characteristic, while also having
Selenium-rich characteristic, healthcare function is waited with antitumor.
People are in edible broccoli, and leaf site is usually discarded, this invention address that utilizing the processing of selenium-rich broccoli
Byproduct is leaf site material, prepares a kind of health food with anti-lung cancer function.Lung is prevented and treated there is presently no broccoli leaf
The report of cancer.
The content of the invention
Present invention aims at provide selenium-rich broccoli leaf-alcohol extract preparing with the health care food for preventing and treating lung cancer function
Purposes in product, the present invention also provides a kind of health food using selenium-rich broccoli leaf-alcohol extract as active component.
The active component with the health food for preventing and treating lung cancer function that the present invention is provided is that selenium-rich broccoli leaf-alcohol is extracted
Thing.
Preferably, the selenium-rich broccoli leaf-alcohol extract is prepared as follows：By total Se content be 50~
100ug/g selenium-rich broccoli leaf volumetric concentration is extracted for 50~90% ethanol, and extract solution is freezed after being concentrated under reduced pressure
Dry, obtained freeze-dried powder is selenium-rich broccoli leaf-alcohol extract.
It is further preferred that the volumetric concentration of the ethanol is 75%.
It is further preferred that the health food is candy or chewable tablets.
Cell assay in vitro result shows that selenium-rich broccoli leaf-alcohol extract has stronger to the propagation of human lung carcinoma cell
Inhibitory action, is significantly better than water extract, and the inhibitory activity of 75% ethanol extract is most strong, therefore resists available for preparing to have
The health product of lung cancer function.
The beneficial effects of the invention are as follows：
(1) it is prepared into the health food with anti-lung cancer function using the leaf site of selenium-rich broccoli first.
(2) raw material used herein is selenium-rich broccoli leaf site, and broccoli leaf is often abandoned as discarded object,
Therefore the present invention is conducive to economizing on resources, and improves the economic and social benefit of agricultural planting.
(3) not only antitumous effect is good for the selenium-rich broccoli leaf-alcohol extract that the present invention is provided, and product yield high.
(4) health food that the present invention is provided is edible, easy to carry, in good taste, without any side effects, is a kind of pure day
Right health food.
Brief description of the drawings
Fig. 1 is the inhibiting rate curve map that various concentrations broccoli alcohol extract is bred to human lung cancer cell A549.
Embodiment
The present invention is described in detail below by specific embodiment.
Embodiment 1
A kind of to have the candy for preventing and treating lung cancer function, the raw material that it is matched by following weight is made：
Preparation method is as follows：
(1) it is 52.19ug/g selenium-rich broccoli leaves to take Se content, is extracted with volumetric concentration for 75% alcohol reflux, material
Liquid weight ratio is 1:20, Extracting temperature is 70 DEG C, and extraction time is 2 times, and each extraction time is 2 hours, is merged after extracting
Decoction, less than 70 DEG C are concentrated under reduced pressure, concentrate freeze-drying obtain freeze-dried powder, as selenium-rich broccoli leaf-alcohol extract.
(2) it is fine with maltodextrin, D-sorbite, cornstarch, crystallite by the alcohol extract ultramicro grinding of selenium-rich broccoli leaf
Dimension element is sufficiently stirred for mixing, and is dried 55~65 minutes at 60~70 DEG C after 25~30 minutes, magnesium stearate is added, by a piece of
2 gram quantity meters, are pressed into candy.
Embodiment 2
A kind of to have the chewable tablets for preventing and treating lung cancer function, the raw material that it is matched by following weight is made：
Selenium-rich broccoli leaf extract 8Kg
Mannitol 91Kg
Magnesium stearate 1Kg
Preparation method is as follows：
(1) preparation method of selenium-rich broccoli leaf-alcohol extract is same as Example 1.
(2) by the alcohol extract ultramicro grinding of selenium-rich broccoli leaf, with mannitol be sufficiently stirred for mix, after 25~30 minutes
Dried 40~50 minutes at 60~70 DEG C, add magnesium stearate, be molded, based on a piece of 2 gram quantity, chewable tablets is made in tabletting.
Test example 1：The determination of selenium-rich broccoli leaf extract extraction conditions
The selection of concentration of alcohol：5 grams of broccoli leaf accurately is weighed in round-bottomed flask, adds 100mL different concentration ethanols
Solution (0%, 30%, 50%, 75%, 85%), refluxing extraction 2~3 times at 70 DEG C merge the extract solution collected several times, subtracted
Pressure concentration, freeze-drying obtains extract freeze-drying powder, and by evaluation index of yield contrast different concentration ethanol solution extraction
Effect.
Cell：Human lung cancer cell A549, purchased from Shanghai Sheng Ke institutes of Chinese Academy of Sciences cell resource center；
Broccoli leaf：For selenium-rich broccoli leaf, Se content is 52.19ug/g, commercially available approach purchase.
The extract of selenium-rich broccoli leaf different concentration ethanol solution is tested human lung cancer cell A549's Proliferation Ability：Take pair
Number growth period human lung cancer cell A549, with 1640 culture mediums dilution adjustment cell density about 1 × 105Individual/mL, is configured to cell and hangs
Supernatant liquid, is inoculated in 96 orifice plates, per hole 100uL, and edge hole is filled with PBS, only adds nutrient solution to be not added with the parallel right of cell while setting
According to 37 DEG C, 5%CO224h is incubated, culture medium in hole is discarded, the various concentrations sample solution configured by basal medium is added
(different concentration ethanol extract), per hole 200uL, and sets negative control, every kind of processing sets 6 repetitions, 37 DEG C, 5% respectively
CO2Cultivate 24h.Then culture medium is suctioned out, 200uL0.5mg/mLMTT solution, 37 DEG C, 5%CO are added per hole2Incubator continues to train
Support 4h.96 orifice plates are taken out, MTT solution in culture, reject hole is terminated, 150uLDMSO is added per hole, hole are determined with ELIASA rapidly
Per absorbance OD of the hole at 490nm in plate, calculate and answer first horizontal oscillations to shake 5min in inhibiting rate (%), continuous mode,
Purple crystal thing in hole is set fully to dissolve, the colorimetric time must not exceed 30min.Experimental result is repeated 3 times, and final result is averaged
Value.
The yield of selenium-rich broccoli leaf different concentration ethanol solution extract and to human lung cancer cell A549's Proliferation Ability
503nhibiting concentration IC50, as a result such as following table：
Table 1：The yield of selenium-rich broccoli leaf different concentration ethanol extract and to human lung cancer cell A549's Proliferation Ability
503nhibiting concentration IC50
| Concentration of alcohol (%) | Extract yield (%) | 503nhibiting concentration IC50(mg/mL) |
| 0 | 15.29±1.25 | 22.73±1.16 |
| 30 | 21.63±0.84 | 2.75±1.16 |
| 50 | 29.67±1.71 | 0.35±0.07 |
| 75 | 37.29±0.68 | 0.18±0.03 |
| 85 | 32.37±0.95 | 0.21±0.02 |
As a result understand：When ethanol solution concentration is 75%, the extract yield highest of selenium-rich broccoli leaf.Due to semi-inhibit
Concentration IC50It is smaller, show that the inhibitory action of medicine is stronger, therefore the ethanol extract of selenium-rich broccoli leaf 75% is to human lung carcinoma cell
The inhibitory action of A549 propagation is most strong, and inhibitory action breed to human lung cancer cell A549 of alcohol extract of selenium-rich broccoli leaf is wanted
It is significantly stronger than water extract (concentration of alcohol is 0).
Test example 2：Selenium-rich broccoli alcohol extracts from the leaves is bred with common broccoli alcohol extracts from the leaves to human lung cancer cell A549 to be pressed down
Experiment processed is compared
Cell：Human lung cancer cell A549, purchased from Shanghai Sheng Ke institutes of Chinese Academy of Sciences cell resource center；
Medicine：Selenium-rich broccoli leaf and the common ethanol extract of broccoli leaf 75%, are produced by the applicant；
Test method is identical with test example 1, investigates various concentrations sample solution (0.2mg/mL, 0.5mg/mL, 1.0mg/
ML, 1.5mg/mL, 2.0mg/mL ethanol extract) to the inhibitory action of human lung cancer cell A549's propagation, as a result see Fig. 1.
As a result show, two kinds of broccoli alcohol extracts from the leaves have inhibitory action, but selenium-rich west for the propagation of human lung carcinoma cell
The Inhibit proliferaton activity of orchid alcohol extracts from the leaves is stronger, and medicinal and health value is higher.
Claims (5)
1. selenium-rich broccoli leaf-alcohol extract is being prepared with the purposes in preventing and treating the health food of lung cancer function.
2. a kind of have the health food for preventing and treating lung cancer function, it is characterised in that：The active component of the health food is selenium-rich
Broccoli leaf-alcohol extract.
3. according to claim 2 have the health food for preventing and treating lung cancer function, it is characterised in that：The selenium-rich broccoli
Leaf-alcohol extract is prepared as follows：By the selenium-rich broccoli leaf volumetric concentration that total Se content is 50~100ug/g
Extracted for 50~90% ethanol, extract solution is freeze-dried after being concentrated under reduced pressure, and obtained freeze-dried powder is selenium-rich broccoli
Leaf-alcohol extract.
4. according to claim 3 have the health food for preventing and treating lung cancer function, it is characterised in that：The volume of the ethanol
Concentration is 75%.
There is the health food for preventing and treating lung cancer function 5. having according to right and asking described in 2~4 any one, it is characterised in that：Institute
Health food is stated for candy or chewable tablets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710390458.6A CN107173805B (en) | 2017-05-27 | 2017-05-27 | Health food with function of preventing and treating lung cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710390458.6A CN107173805B (en) | 2017-05-27 | 2017-05-27 | Health food with function of preventing and treating lung cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107173805A true CN107173805A (en) | 2017-09-19 |
| CN107173805B CN107173805B (en) | 2020-10-09 |
Family
ID=59835143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710390458.6A Active CN107173805B (en) | 2017-05-27 | 2017-05-27 | Health food with function of preventing and treating lung cancer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107173805B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107691746A (en) * | 2017-09-20 | 2018-02-16 | 苏州硒泰克生物科技有限公司 | High selenium broccoli pressed candy and preparation method thereof |
| CN108272072A (en) * | 2017-12-08 | 2018-07-13 | 上海朗礼健康科技有限公司 | Anti-fog haze health food or drug and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800270A (en) * | 2015-05-20 | 2015-07-29 | 皖南医学院 | Preparation method for broccoli sprout extract capsule |
-
2017
- 2017-05-27 CN CN201710390458.6A patent/CN107173805B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104800270A (en) * | 2015-05-20 | 2015-07-29 | 皖南医学院 | Preparation method for broccoli sprout extract capsule |
Non-Patent Citations (1)
| Title |
|---|
| 李向果: "西兰花叶中硫代葡萄糖苷和原花青素的生物学效价评定", 《中国优秀硕士学位论文全文数据库 农业科技辑》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107691746A (en) * | 2017-09-20 | 2018-02-16 | 苏州硒泰克生物科技有限公司 | High selenium broccoli pressed candy and preparation method thereof |
| CN108272072A (en) * | 2017-12-08 | 2018-07-13 | 上海朗礼健康科技有限公司 | Anti-fog haze health food or drug and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107173805B (en) | 2020-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102379326B (en) | Lung-nourishing biscuit and preparation method thereof | |
| CN104982928B (en) | A kind of japanese yew fruit health care ferment and preparation method thereof | |
| CN104585733B (en) | Cordyceps oral tablet and preparation method thereof | |
| CN103919920A (en) | Buccal tablet retaining original ecology of wolfberry fruits and preparation process thereof | |
| CN102600443B (en) | Combination capable of improving immunity and preparation method and application | |
| CN105017438B (en) | A kind of Radix et Rhizoma Gynurae divaricatae polysaccharide and its application in preparing for immunological regulation and anti-tumor drug and functional food | |
| CN102613331B (en) | Halimasch fermented tea and halimasch fermented tea composition, and preparation methods thereof | |
| CN104000192B (en) | A kind of functional food and two-step fermentation preparation method thereof releasing the pressure and regulate stomach | |
| CN103436419B (en) | A kind of health promoting wine prepared with oyster and preparation method thereof | |
| CN107173805A (en) | It is a kind of that there is the health food for preventing and treating lung cancer function | |
| CN110403114A (en) | A kind of process flow of roxburgh rose juice drink | |
| CN104605334A (en) | Cordyceps sinensis oral tablet and preparation method thereof | |
| CN105819967A (en) | Nutrient rich in selenium and iodine, preparing method thereof and method for cultivating tomato rich in selenium and iodine | |
| CN103932180B (en) | A kind ofly to release the pressure and the health food of antifatigue and two-step fermentation preparation method thereof | |
| CN104193845A (en) | Nostoc commune antitumor polysaccharide as well as preparation method and application thereof | |
| CN107468999A (en) | A kind of fermentation composition with beauty treatment and eliminating spot function and preparation method thereof | |
| CN110338426A (en) | A kind of blood enriching effervescent tablet agent and preparation method thereof | |
| CN105434575B (en) | Application of Russian leaves and extract thereof in preparation of liver-protecting medicines or health-care foods | |
| CN103168984A (en) | Health-care aloe capsule for defaecating and detoxifying | |
| KR101306950B1 (en) | Composition for food using medicinal herbs and seonokgyun and manufacturing method thereof | |
| CN103830280A (en) | Preparation method of spirulina extract | |
| CN101396056B (en) | Pine-needle tuckahoe teat and preparation method thereof | |
| CN105876036A (en) | Blood sugar reducing effervescent tablet herbal tea and preparation method thereof | |
| CN112754014A (en) | Composition for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof | |
| CN102166029A (en) | Functional drink of multi-bacterium health-keeping extract of mesona chinensis benth |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |