CN113749277B

CN113749277B - Atomized liquid with ambergris fragrance and preparation method thereof

Info

Publication number: CN113749277B
Application number: CN202111071423.9A
Authority: CN
Inventors: 邹军; 邹阳; 刘梅森
Original assignee: Shenzhen Zinwi Biotech Co Ltd
Current assignee: Shenzhen Zinwi Biotech Co Ltd
Priority date: 2021-09-11
Filing date: 2021-09-11
Publication date: 2023-09-12
Anticipated expiration: 2041-09-11
Also published as: CN113749277A

Abstract

The application relates to the technical field of atomized liquid, and in particular discloses an atomized liquid with ambergris fragrance, which is prepared from the following raw materials in parts by weight: 45-65 parts of propylene glycol, 41-55 parts of glycerol, 3-7 parts of xylitol, 12-16 parts of ambergris essence, 0.3-0.7 part of tobacco extract and 2-6 parts of radix isatidis extract; the tobacco extract is subjected to deproteinization modification treatment. The atomized liquid has the effect of higher ambergris aroma reduction degree, and can reduce harm to human throats caused by smoking.

Description

Atomized liquid with ambergris fragrance and preparation method thereof

Technical Field

The application relates to the technical field of atomized liquid, in particular to an atomized liquid with ambergris fragrance and a preparation method thereof.

Background

The electronic atomization device has a large market prospect as a novel tobacco system, and the main reason is that: on the one hand, the electronic atomization device can provide similar consumption habit and satisfaction as those of the traditional cigarettes; on the other hand, the hazard index of the electronic atomization device is greatly reduced compared with that of the traditional cigarette. The low harm of the electronic atomization device is that the electronic atomization device adopts a non-combustion mode to generate aroma, and atomized liquid is sucked into a human body instead of combustion cracking products, so that the electronic atomization device can not generate harmful substances such as tar, carbon monoxide, carbon dioxide, acrolein and the like, and the electronic atomization device is regarded as a pollution-free smoking cessation product or a tobacco substitute.

The atomized liquid is electronic atomized liquid matched with the electronic atomization device, and the electronic atomization device is utilized to heat the atomized liquid, so that fog like cigarettes can be generated. The main components of the atomized liquid are edible or medical grade glycerin, 1, 2-propylene glycol, polyethylene glycol and tobacco special essence. The glycerin has strong water absorbability, and can absorb saliva in the oral cavity after entering the oral cavity, so that the problems of dry mouth and tongue, sore throat and the like of smokers are caused.

Disclosure of Invention

In order to improve the uncomfortable feeling of the oral cavity after sucking the atomized liquid, the application provides the atomized liquid with ambergris fragrance and a preparation method thereof.

In a first aspect, the application provides an atomized liquid with ambergris fragrance, which adopts the following technical scheme:

an atomized liquid with ambergris fragrance is prepared from the following raw materials in parts by weight: 45-65 parts of propylene glycol, 41-55 parts of glycerol, 3-7 parts of xylitol, 12-16 parts of ambergris essence, 0.3-0.7 part of tobacco extract and 2-6 parts of radix isatidis extract; the tobacco extract is subjected to deproteinization modification treatment.

By adopting the technical scheme, under the condition that no nicotine is added in the atomized liquid, the taste requirement of a smoker on the atomized liquid is met. The addition of propylene glycol gives the atomized liquid a throat-hitting feel when inhaled, and glycerin is the main raw material for generating smoke. The physical and chemical properties of xylitol are similar to those of glycerin, and meanwhile, the xylitol can promote the secretion of saliva in the oral cavity, remarkably increase the flow rate of saliva in the oral cavity, and effectively relieve the problems of dry mouth, dry tongue, sore throat and the like after the electronic atomization device is used. Xylitol replaces part of glycerol, reduces the amount of glycerol, and reduces the saliva amount in the oral cavity caused by the glycerol entering the oral cavity, so that the problems of dry mouth and tongue, even sore throat and the like are caused.

Ambergris is an animal spice, a dried secretion of sperm whales, which has a unique sweet and earthy fragrance, and is expensive and more precious due to the fact that the number of sperm whales in the world is smaller and smaller. The addition of ambergris essence makes the atomized liquid possess ambergris fragrance. The radix isatidis has the functions of resisting inflammation, clearing heat and detoxicating, relieving sore throat, preventing and relieving sore throat, solving the taste requirement of smokers on atomized liquid and reducing the harm of tobacco leaves of the electronic atomization device to the throat.

The tobacco extract can enable the atomized liquid to have the aroma of tobacco, meets the taste requirement of smokers on the aroma of the atomized liquid tobacco, but contains a large amount of protein, and the too high protein content of the atomized liquid can reduce the aroma and taste of the tobacco liquid and can generate spicy taste, bitter taste and irritation. By removing proteins from tobacco, the aroma and taste of the atomized liquid can be improved. The atomized liquid disclosed by the application not only has noble and elegant ambergris fragrance, but also improves the taste of the tobacco liquid, and relatively improves the problem of sore throat caused by a smoker after sucking the electronic atomization device.

As preferable: the composite material is prepared from the following raw materials in parts by weight: 50-55 parts of propylene glycol, 44.5-51.5 parts of glycerin, 4-6 parts of xylitol, 13-15 parts of ambergris essence, 0.4-0.6 part of tobacco extract and 3-5 parts of radix isatidis extract.

As preferable: the tobacco extract is extracted from the following raw materials in parts by weight: 1-5 parts of tobacco leaves, 5-9 parts of deionized water and 6-30 parts of ethyl acetate.

By adopting the technical scheme, most substances in the tobacco can be dissolved by deionized water, wherein the substances comprise nicotine, sugar, amino acid, protein, inorganic salt, organic acid salt and the like. The ethyl acetate can dissolve and remove a large amount of substances in the tobacco, including tobacco aroma, such as neophytadiene, multiple substances and the like, so as to ensure the tobacco aroma of the atomized liquid.

As preferable: the modification treatment operation of deproteinizing the tobacco extract is specifically as follows: drying and crushing tobacco leaves, adding the crushed tobacco leaves into deionized water, performing ultrasonic extraction, adjusting the pH to 10-13, distilling, and collecting precipitate A and distillate A; regulating the pH of the distillate A to 3-5, filtering, collecting filtrate, adding the filtrate into ethyl acetate for extraction, filtering, and collecting an extract B; mixing the extract B with the precipitate A, adjusting pH to 6-8, concentrating under reduced pressure, and oven drying to obtain tobacco extract.

By adopting the technical scheme, the tobacco leaves are dried and crushed, so that the extraction of internal substances is facilitated, and deionized water can dissolve most substances in the tobacco leaves, including nicotine, sugar, amino acid, protein, inorganic salt, organic acid salt and the like. Protein is dissolved under alkaline condition and has precipitation characteristic under acidic condition, the pH of the extracted liquid is regulated to be alkaline, so that the protein is dissolved in distillate A, then the distillate A is regulated to be acidic liquid, so that the protein is precipitated, the purpose of removing the precipitate after the second extraction is to remove the protein, and the precipitate A and the extract B are improved tobacco extracts after the protein is removed.

As preferable: the ambergris essence is prepared from the following raw materials in parts by weight: 1-3 parts of ambroxol, 0.4-0.5 part of ambroxol, 0.01-0.03 part of linalool, 0.05-0.07 part of isophorone oxide, 0.5-0.7 part of ethyl maltol, 0.04-0.06 part of beta-ionone, 0.04-0.06 part of furanone and 5-7 parts of ethanol.

By adopting the technical scheme, ambroxol provides the fragrance of main fragrance, ambroxol can greatly improve the diffusion effect of essence, and has no stimulation to human body. In addition, linalool and beta-ionone are modified aroma, and ethyl maltol and furanone play a role in sweetening.

As preferable: the weight ratio of ambroxol to ambroxol ether is 1: (3-5).

As preferable: the weight portion ratio of the glycerol to the propylene glycol is 1: (1.1-1.3).

By adopting the technical scheme, the main effect of the glycerol is to increase the smoke quantity which can be generated by the atomized liquid, and the propylene glycol can generate a small quantity of mist after being heated and has a certain throat feeling. The glycerin absorbs saliva in the oral cavity, so that the mouth and tongue of a smoker are dry, the throat is sore, and the dosage of the glycerin can be reduced by the matched addition of the propylene glycol and the glycerin, so that the taste of the atomized liquid is improved.

In a second aspect, the present application provides a method for preparing any one of the above atomized liquids, which is specifically implemented by the following technical scheme:

an atomized liquid with ambergris fragrance, comprising the following steps of:

weighing ambergris essence for standby;

weighing propylene glycol, glycerol, xylitol, tobacco extract and radix Isatidis extract, and mixing uniformly to obtain mother liquor;

adding ambergris essence into the mother liquor, stirring uniformly, aging for 15-25h after the raw materials are completely dissolved, and obtaining the atomized liquid with ambergris fragrance.

By adopting the technical scheme, the raw materials of the ambergris essence are uniformly mixed firstly, then the ambergris essence is added into the mother liquor, so that the ambergris essence is more convenient to dissolve, and the ambergris essence is aged to ensure that the fragrance of ambergris is more integral and stable.

In summary, the present application includes at least one of the following beneficial technical effects:

(1) The aroma and sensory index of the atomized liquid are generally higher than those of comparative examples 1-4, and the atomized liquid has good taste and smell and higher reduction degree of ambergris fragrance. The score of the throat feel of the atomized liquid of examples 1-25 is 11-20 minutes, and the throat feel of the atomized liquid of comparative examples 1-4 is 9-12 minutes, and the throat feel score of the atomized liquid of examples 1-25 is obviously higher than the throat feel of the atomized liquid of comparative examples 1-4, so that the discomfort of the throat of a smoker after smoking the atomized liquid is obviously improved.

(2) The maximum fragrance of the atomized liquid can reach 27 minutes, and the atomized liquid has the effect of higher ambergris fragrance reduction degree.

Detailed Description

The present application will be described in further detail with reference to specific examples.

The following raw materials in the application are all commercial products, and specifically: xylitol is selected from Henan Huayue chemical products limited company, and the content of effective substances is 99%; radix Isatidis is selected from the company of Yihongtang pharmaceutical Co., bozhou; ambroxol is selected from the Syngnathus Hua Xiangke biological technology limited company, and the content of effective substances is 95%; ambroxol is selected from Hebei Danming biotechnology limited company, the content of effective substances is 99%, and the product number is DM521; linalool and beta-ionone are selected from Kang Disi chemical industry (Hubei) limited company, and the content of effective substances is 99%; ethyl maltol is selected from Zhengzhou kernel chemostat products limited company, and the content of active ingredients is 99%; isophorone oxide is selected from Hunan Hui Rui pharmaceutical Co., ltd, and has 97% active substance content.

The following are examples of tobacco extracts in the present application:

preparation example 1

The specific operation of deproteinizing and modifying the tobacco extract in the application is as follows:

drying and crushing tobacco leaves to 60 meshes, and performing ultraviolet sterilization to obtain powder A;

adding the powder A into deionized water, performing ultrasonic extraction for 4 hours at 60 ℃, and filtering to obtain an extract A;

adding sodium hydroxide into the extract A to adjust the pH of the extract A to 12, distilling at 80 ℃, collecting precipitate A and distillate A, adding malic acid into the distillate A to adjust the pH to 4, filtering, leaving filtrate, adding the filtrate into ethyl acetate for extraction, filtering, and collecting extract B; mixing the extract B with the precipitate A, adding sodium hydroxide to adjust pH to 7, concentrating under reduced pressure, and oven drying at 40deg.C to obtain tobacco extract.

PREPARATION EXAMPLES 2 to 5

The modified tobacco extracts of preparation examples 2 to 5 were identical to the preparation method of preparation example 1, except that the amounts of the respective raw materials were different, and the details are shown in Table 1.

TABLE 1 preparation examples 1-5 amounts of raw materials of modified tobacco extract (unit: g)

Raw materials	Preparation example 1	Preparation example 2	Preparation example 3	Preparation example 4	Preparation example 5
						Tobacco leaf	100	200	300	400	500
Acetic acid ethyl ester	600	1200	1800	2400	3000
						Deionized water	500	600	700	800	900

Preparation example 6

The modified tobacco extract of preparation example 6 is identical to the raw materials and blending amount of preparation example 1, except that the modification treatment operation of deproteinizing the tobacco extract is specifically as follows: drying and crushing tobacco leaves to 60 meshes, and performing ultraviolet sterilization to obtain powder A;

adding sodium hydroxide into the extract A to adjust the pH of the extract A to 12, distilling at 80 ℃, and collecting precipitate A and distillate A; adding malic acid into the distillate A to adjust the pH to 4, filtering, collecting filtrate, and uniformly mixing the filtrate with the precipitate A to obtain a mixture A; adding sodium hydroxide into the mixture A to adjust pH to 7, concentrating under reduced pressure, and oven drying at 40deg.C to obtain tobacco extract.

The following is a preparation example of ambergris essence in the application:

preparation example 7

The ambergris essence in the application is specifically prepared by the following steps:

1. according to the mixing amount of the table 2, ambroxol and ambroxol are added into ethanol and stirred to be dissolved, so as to obtain solution A;

2. linalool, isophorone oxide, ethyl maltol, furanone and beta-ionone are added into the solution A, and stirred in a closed stirring kettle until being uniformly mixed.

Preparation examples 8 to 11

Preparation examples 8-11 ambergris essence and preparation example 7 were identical in preparation method, except that each raw material component was different, and specific details are shown in table 2.

TABLE 2 preparation examples 7-11 mixing amount of raw materials of ambergris essence (unit: g)

Preparation examples 12 to 16

Ambergris essence of preparation examples 12-16 is identical to the preparation method of preparation example 9, except that the raw material components are different, and the details are shown in table 3.

TABLE 3 preparation examples 12-16 ambergris essence raw materials blend (unit: g)

Preparation example 17

The preparation method of the isatis root extract comprises the following steps: mixing radix Isatidis with 60% ethanol at mass concentration of 1:8, uniformly mixing the materials in a weight ratio, and standing for 4 hours to obtain an isatis root extracting solution; placing the obtained radix Isatidis extract on macroporous resin adsorption column, washing macroporous resin adsorption column with deionized water until effluent is colorless, eluting with 80% pure ethanol, collecting eluate, filtering, collecting residue, and oven drying to obtain radix Isatidis extract.

Example 1

An atomized liquid with ambergris fragrance is prepared by the following steps:

weighing ambergris essence of preparation example 7 for standby;

weighing the tobacco extract of preparation example 1, propylene glycol, glycerol, xylitol and radix Isatidis extract of preparation example 17, and mixing uniformly to obtain mother liquor;

adding ambergris essence into the mother liquor, stirring uniformly, aging for 25 hours after the raw materials are completely dissolved, and obtaining the atomized liquid with ambergris fragrance.

Examples 2 to 5

The atomized solutions of examples 2 to 5 were identical to the preparation method and the types of raw materials of example 1, except that the amounts of the raw materials were different, and the details are shown in Table 4.

TABLE 4 amounts of raw materials (unit: g) for the atomized solutions of examples 1 to 5

Examples 6 to 10

The atomized solutions of examples 6 to 10 were identical to the preparation method and the types of raw materials of example 4, except that the amounts of the raw materials were different, and the details are shown in Table 5.

TABLE 5 amounts of raw materials (unit: g) for atomized solutions of examples 6 to 10

Examples 11 to 15

The atomized liquid of examples 11 to 15 was identical to the preparation method and the kind of the raw materials of example 8, except that the tobacco extracts prepared in preparation examples 2 to 6 were used as the raw materials, and the remaining raw materials and the blending amounts were identical to those of example 8.

Example 16

The atomized liquid of example 16 was identical to the preparation method of example 12, except that: ambroxol is not added into ambroxol essence raw materials, and the other raw materials and the mixing amount are the same as in example 12.

Examples 17 to 25

The atomized liquid of examples 17-25 is identical to the preparation method and the raw material type of example 12, except that ambergris essence prepared in preparation examples 8-16 is selected as the raw material, and the rest raw materials and the mixing amount are identical to those of example 12. Comparative example 1

The atomized liquid of comparative example 1 was identical to the preparation method of example 2, except that: xylitol was not added to the raw materials, and the other raw materials and the blending amounts were the same as in example 2.

Comparative example 2

The atomized liquid of comparative example 2 was identical to the preparation method of example 2, except that: the modification treatment operation of deproteinizing the tobacco extract is specifically as follows: drying and crushing tobacco leaves, adding the crushed tobacco leaves into deionized water, performing ultrasonic extraction, filtering, collecting an extract, concentrating the extract under reduced pressure, and drying to obtain a tobacco extract.

Comparative example 3

The atomized liquid of comparative example 3 was identical to the preparation method of example 2, except that: the tobacco extract was not added to the raw materials, and the other raw materials and the blending amount were the same as in example 2.

Comparative example 4

The atomized liquid of comparative example 4 was identical to the preparation method of example 2, except that: the materials were not added with the isatis root extract, and the other materials and the blending amount were the same as in example 2.

Performance detection

The atomized liquids obtained in examples 1 to 25 and comparative examples 1 to 4 were respectively added to an electronic atomizer, and the atomized liquids were subjected to flavor and sensory evaluation by the following methods: selecting 20 smoke age assessment staff over 10 years, referring to a fragrance and sensory evaluation table of each atomized liquid in tables 10-14, adopting a dark assessment scoring mode, pumping the atomized liquid by using a three-section assessment method, and comprehensively scoring the fragrance and sensory quality of the atomized liquid by adopting a percentage scoring method according to a three-section scoring table of an initial stage, a middle stage and a tail stage in table 6 and a sensory index and grade classification scoring table of tables 7-9.

Table 6 three-section score distribution table

TABLE 7 sensory index and grade classification scoring Table

TABLE 8 sensory index and grade classification scoring Table

TABLE 9 sensory index and grade classification scoring Table

Table 10 table of fragrance and sensory evaluation of different atomized liquids

TABLE 11 fragrance and sensory evaluation Table of different atomized liquids

Table 12 table of flavor and sensory evaluation of different atomized liquids

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TABLE 13 fragrance and sensory evaluation of various atomized liquids

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TABLE 14 fragrance and sensory evaluation of various atomized liquids

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As can be seen from tables 10 to 14, the aroma and sensory index score of the atomized liquid with ambergris aroma of the application are generally higher than those of comparative examples 1 to 4, and the atomized liquid has good taste and smell, the throat-entering score of the atomized liquid of examples 1 to 25 is 11 to 20, the throat-entering score of comparative examples 1 to 4 is 9 to 12, the throat-entering score of the atomized liquid of examples 1 to 25 is obviously higher than the throat-entering score of the atomized liquid of comparative examples 1 to 4, and the discomfort of the throat of smokers in the smoking process is remarkably relieved. In addition, the atomized liquid has higher reduction degree of ambergris fragrance.

In examples 1-5, the atomized liquid of example 3 had generally higher odor, nasal sensation, entrance aroma, flavor and taste fractions than those of the atomized liquids of examples 1-2 and examples 4-5, wherein the degree of recognition of the flavor and aroma was as high as 21 and 5, respectively, and it was found that the raw materials of the atomized liquid of example 3 were more suitable in terms of weight parts for preparing the atomized liquid.

In examples 6-10, the inlet fragrance, throat feel and nasal cavity feel of the atomized liquid of example 7 are 10 minutes, 8 minutes and 9 minutes, which are obviously higher than those of examples 6 and examples 8-10, and the fact that when the weight ratio of glycerin to xylitol in the atomized liquid raw material is 1:1.2, the throat feel and nasal cavity feel are improved, so that the fragrance and the taste of the atomized liquid are excellent.

In examples 11-14, the flavor and aroma perception of the atomized liquid of example 12 were 29 minutes and 5 minutes, which are higher than those of the atomized liquids of examples 11 and examples 13-14, indicating that the tobacco extract prepared in preparation example 3 was more suitable for preparing the atomized liquid and had a more pronounced ambergris aroma. Example 15 the fragrance of the atomized liquid was 12, which was lower than examples 11-14, indicating that the addition of the filtrate to ethyl acetate for a second extraction effectively enhanced the fragrance of the atomized liquid. The fragrance of the atomized liquid in example 16 is 21 minutes and is generally lower than that of the atomized liquid in example 13, which indicates that the ambroxol added into ambroxol essence improves the taste of smokers and the fragrance of ambroxol, and improves the residual feeling of ambroxol fragrance.

The atomized liquid of example 18 had a residual feel of 10 minutes, which was higher than those of the atomized liquids of examples 17 and 19 to 20, indicating that the atomized liquid of preparation example 8 was more suitable in terms of the parts by weight of the respective raw materials and exhibited excellent residual feel of fragrance.

In examples 21-25, the throat feel of example 22 was 20 minutes, the mouth feel was 14 minutes, the residual feel was 10 minutes, which is higher than examples 21 and 23-25, showing that when the weight ratio of ambroxol to ambroxol in ambroxol essence raw materials was 1:4, the ambroxol aroma of the atomized liquid was more stable, and the problems of dry mouth and sore throat after inhaling the smog of the atomized liquid were also improved.

The flavor and the sense of the atomized liquid of the comparative examples 1-4 are evaluated, and the addition of xylitol and the isatis root extract in the atomized liquid can improve the throat feeling and the nasal feeling of a smoker, and the addition of the tobacco extract and the deproteinization improvement of the tobacco extract greatly improve the flavor of ambergris, thereby meeting the sense and the sense requirement of the smoker on the atomized liquid.

The present embodiment is only for explanation of the present application and is not to be construed as limiting the present application, and modifications to the present embodiment, which may not creatively contribute to the present application as required by those skilled in the art after reading the present specification, are all protected by patent laws within the scope of claims of the present application.

Claims

1. An atomized liquid with ambergris fragrance is characterized by being prepared from the following raw materials in parts by weight: 45-65 parts of propylene glycol, 41-55 parts of glycerol, 3-7 parts of xylitol, 12-16 parts of ambergris essence, 0.3-0.7 part of tobacco extract and 2-6 parts of radix isatidis extract; the weight portion ratio of the glycerol to the propylene glycol is 1:1.2;

the tobacco extract is subjected to deproteinization modification treatment; the modification treatment operation of deproteinizing the tobacco extract is specifically as follows: drying and crushing tobacco leaves, adding the crushed tobacco leaves into deionized water, performing ultrasonic extraction, adjusting the pH to 10-13, distilling, and collecting precipitate A and distillate A; regulating the pH of the distillate A to 3-5, filtering, collecting filtrate, adding the filtrate into ethyl acetate for extraction, filtering, and collecting an extract B; mixing the extract B with the precipitate A, adjusting pH to 6-8, concentrating under reduced pressure, and oven drying to obtain tobacco extract;

the ambergris essence is prepared from the following raw materials in parts by weight: 1-3 parts of ambroxol, 0.4-0.5 part of ambroxol, 0.01-0.03 part of linalool, 0.05-0.07 part of isophorone oxide, 0.5-0.7 part of ethyl maltol, 0.04-0.06 part of beta-ionone, 0.04-0.06 part of furanone and 5-7 parts of ethanol; the weight ratio of ambroxol to ambroxol is 4:1;

the atomized liquid with ambergris fragrance is prepared through the following operation steps: weighing ambergris essence for standby; weighing propylene glycol, glycerol, xylitol, tobacco extract and radix Isatidis extract, and mixing uniformly to obtain mother liquor; adding ambergris essence into the mother liquor, stirring uniformly, aging for 15-25h after the raw materials are completely dissolved, and obtaining the atomized liquid with ambergris fragrance.

2. The atomized liquid with ambergris fragrance according to claim 1, wherein the tobacco extract is extracted from raw materials comprising the following parts by weight: 1-5 parts of tobacco leaves, 5-9 parts of deionized water and 6-30 parts of ethyl acetate.