CN113749277A

CN113749277A - Atomized liquid with ambergris fragrance and preparation method thereof

Info

Publication number: CN113749277A
Application number: CN202111071423.9A
Authority: CN
Inventors: 邹军; 邹阳; 刘梅森
Original assignee: Shenzhen Zinwi Biotech Co Ltd
Current assignee: Shenzhen Zinwi Biotech Co Ltd
Priority date: 2021-09-11
Filing date: 2021-09-11
Publication date: 2021-12-07
Anticipated expiration: 2041-09-11
Also published as: CN113749277B

Abstract

The application relates to the technical field of atomized liquid, and particularly discloses atomized liquid with ambergris fragrance, which is prepared from the following raw materials in parts by weight: 45-65 parts of propylene glycol, 41-55 parts of glycerol, 3-7 parts of xylitol, 12-16 parts of ambergris essence, 0.3-0.7 part of tobacco extract and 2-6 parts of isatis root extract; the tobacco extract is subjected to deproteinization modification treatment. The atomized liquid has the effect of higher degree of reduction of ambergris fragrance, and can also reduce the harm to the throat of a human body caused by smoking.

Description

Atomized liquid with ambergris fragrance and preparation method thereof

Technical Field

The application relates to the technical field of atomized liquid, in particular to atomized liquid with ambergris fragrance and a preparation method thereof.

Background

Electronic atomization device has great market prospect as novel tobacco system, and its leading cause lies in: on the one hand, electronic atomization devices can provide similar consumption habits and satisfaction as traditional cigarettes; on the other hand, the hazard index of the electronic atomization device is greatly reduced compared with that of the traditional cigarette. The electronic atomization device has low harm because the electronic atomization device generates fragrance in a non-combustion mode, atomized liquid rather than combustion cracking products is inhaled into a human body, and therefore the electronic atomization device does not generate harmful substances such as tar, carbon monoxide, carbon dioxide, acrolein and the like, and is considered as a non-polluted smoking cessation product or a tobacco substitute.

The atomized liquid is an electronic atomized liquid used in cooperation with an electronic atomization device, and the atomized liquid is heated by the electronic atomization device to generate mist like cigarettes. The main components of the atomized liquid are edible or medical glycerin, 1, 2-propylene glycol, polyethylene glycol and tobacco essence. Wherein, glycerin has strong water absorption, and can absorb saliva in oral cavity after entering the oral cavity, which causes the problems of dry mouth and tongue, sore throat and the like of smokers.

Disclosure of Invention

In order to improve the discomfort of the oral cavity after the atomized liquid is sucked, the application provides the atomized liquid with ambergris fragrance and a preparation method thereof.

In a first aspect, the application provides an atomized liquid with ambergris fragrance, which adopts the following technical scheme:

an atomized liquid with ambergris fragrance is prepared from the following raw materials in parts by weight: 45-65 parts of propylene glycol, 41-55 parts of glycerol, 3-7 parts of xylitol, 12-16 parts of ambergris essence, 0.3-0.7 part of tobacco extract and 2-6 parts of isatis root extract; the tobacco extract is subjected to deproteinization modification treatment.

By adopting the technical scheme, under the condition that no nicotine is added into the atomized liquid, the taste requirement of smokers on the atomized liquid is met. The addition of propylene glycol makes the atomized liquid have throat-hitting feeling when inhaled, and glycerin is the main raw material for generating smoke. The xylitol has similar physical and chemical properties to glycerin, and can promote the secretion of saliva in the oral cavity, remarkably increase the flow rate of saliva in the oral cavity, and effectively relieve the problems of dry mouth and tongue, sore throat and the like after the electron-withdrawing atomization device is used. Xylitol replaces part of glycerin, the glycerin amount is also reduced, and the problems of dry mouth and tongue, even throat pain and the like caused by the fact that the glycerin enters the oral cavity to absorb saliva in the oral cavity are reduced.

Ambergris is an animal spice, is secretion of dried sperm whale, has unique sweet soil fragrance, and is expensive and more precious due to the fact that the quantity of sperm whales in the world is less and less. The addition of the ambergris essence can make the atomized liquid have ambergris fragrance. The radix Isatidis has effects of resisting inflammation, clearing heat and detoxicating, relieving sore throat, preventing and relieving sore throat, and can meet the requirement of smoker on the taste of atomized liquid and reduce the harm of tobacco leaf of electronic atomization device to throat.

The tobacco extract can make the atomized liquid have the fragrance of tobacco and meet the requirement of smokers on the taste of the atomized liquid tobacco fragrance, but the tobacco extract contains a large amount of protein, and the too high content of the protein in the atomized liquid can reduce the fragrance and the taste of the tobacco liquid and can generate spicy taste, bitter taste and irritation. By removing protein in tobacco, the aroma and taste of the atomized liquid can be improved. The atomized liquid has noble and elegant ambergris fragrance, improves the taste of the cigarette liquid, and relatively improves the problem of swollen sore throat caused by smokers after an electronic atomization device is inhaled.

Preferably, the method comprises the following steps: the composition is prepared from the following raw materials in parts by weight: 50-55 parts of propylene glycol, 44.5-51.5 parts of glycerol, 4-6 parts of xylitol, 13-15 parts of ambergris essence, 0.4-0.6 part of tobacco extract and 3-5 parts of isatis root extract.

Preferably, the method comprises the following steps: the tobacco extract is obtained by extracting the following raw materials in parts by weight: 1-5 parts of tobacco leaves, 5-9 parts of deionized water and 6-30 parts of ethyl acetate.

By adopting the technical scheme, the deionized water can dissolve most substances in the tobacco, wherein the substances comprise nicotine, sugar, amino acid, protein, inorganic salt, organic acid salt and the like. The ethyl acetate can dissolve a large amount of substances in the tobacco, including tobacco fragrance, such as neophytadiene and multi-component substances, and ensure the tobacco fragrance of the atomized liquid.

Preferably, the method comprises the following steps: the operation of the deproteinization modification treatment of the tobacco extract is as follows: drying and crushing tobacco leaves, adding the tobacco leaves into deionized water, carrying out ultrasonic extraction, adjusting the pH value to 10-13, distilling, and collecting a precipitate A and a distillate A; adjusting the pH of the distillate A to 3-5, filtering, collecting the filtrate, extracting the filtrate with ethyl acetate, filtering, and collecting the extract B; mixing the extractive solution B and the precipitate A uniformly, adjusting pH to 6-8, concentrating under reduced pressure, and oven drying to obtain tobacco extract.

By adopting the technical scheme, the tobacco leaves are dried and crushed, so that internal substances can be extracted more conveniently, and most substances in the tobacco can be dissolved by deionized water, wherein the substances comprise nicotine, sugar, amino acid, protein, inorganic salt, organic acid salt and the like. The protein is dissolved under alkaline condition, and precipitated under acidic condition, by adjusting pH of the extracted liquid to alkaline, the protein is dissolved in distillate A, then the distillate A is adjusted to acidic liquid, the protein is precipitated, the precipitate after the second extraction is removed for removing the protein, and the precipitate A and the extract B are modified tobacco extract after removing the protein.

Preferably, the method comprises the following steps: the ambergris essence is prepared from the following raw materials in parts by weight: 1-3 parts of ambroxol, 0.4-0.5 part of ambroxol, 0.01-0.03 part of linalool, 0.05-0.07 part of oxidized isophorone, 0.5-0.7 part of ethyl maltol, 0.04-0.06 part of beta-ionone, 0.04-0.06 part of furanone and 5-7 parts of ethanol.

By adopting the technical scheme, ambergris alcohol provides the fragrance of the main fragrance, and ambergris ether can greatly improve the diffusion effect of the essence without any stimulation to human bodies. In addition, linalool and beta-ionone are used for modifying fragrance, and ethyl maltol and furanone play a role in sweetening.

Preferably, the method comprises the following steps: the weight ratio of ambergris alcohol to ambergris ether is 1: (3-5).

Preferably, the method comprises the following steps: the weight ratio of the glycerol to the propylene glycol is 1: (1.1-1.3).

By adopting the technical scheme, the glycerol mainly has the effect of increasing the amount of smoke generated by the atomized liquid, and the propylene glycol can generate a small amount of smoke after being heated and has certain throat-hitting feeling. The glycerin absorbs saliva of oral cavity, which causes dry mouth and tongue, and swelling and pain in throat, and the addition of propylene glycol and glycerin can reduce the amount of glycerin, thereby improving the taste of the atomized liquid.

In a second aspect, the present application provides a method for preparing any one of the above atomized liquids, which is specifically realized by the following technical scheme:

an atomized liquid with ambergris fragrance comprises the following operation steps:

weighing ambergris essence for later use;

weighing propylene glycol, glycerol, xylitol, tobacco extract and radix Isatidis extract, mixing well, and making into mother liquor;

adding ambergris essence into the mother liquor, stirring, dissolving the raw materials completely, aging for 15-25h to obtain atomized liquid with ambergris fragrance.

By adopting the technical scheme, the raw materials of the ambergris essence are uniformly mixed firstly, and then added into the mother solution, so that the ambergris essence is more convenient to dissolve, and the aging aims to ensure that the fragrance of the ambergris essence is more integral and more stable.

In summary, the present application includes at least one of the following beneficial technical effects:

(1) the aroma and sensory index of the atomized liquid are generally higher than the aroma and sensory index scores of the comparative examples 1-4, and the atomized liquid has good taste and smell and higher degree of reduction of ambergris aroma. The throat-entering feeling scores of the atomized liquids of examples 1 to 25 are 11 to 20 points, the throat-entering feeling scores of comparative examples 1 to 4 are 9 to 12 points, the throat-entering feeling scores of the atomized liquids of examples 1 to 25 are obviously higher than that of the atomized liquids of comparative examples 1 to 4, and the discomfort of the throat of a smoker after smoking the atomized liquid is obviously improved.

(2) The atomized liquid has the fragrance of 27 minutes at most and has the effect of higher ambergris fragrance reduction degree.

Detailed Description

The present application will be described in further detail with reference to specific examples.

The following raw materials in the application are all commercially available products, and specifically: the xylitol is selected from Henan Huayue chemical products, and the content of effective substances is 99 percent; the radix Isatidis is selected from Bozhou market Yihongtang pharmaceutical industry Co Ltd; ambroxol is selected from Wuhan Hua Bifujie biotechnology limited, and contains 95% of effective substance; ambroxol is selected from Hebei Danming Biotech limited, with an active substance content of 99% and a product number of DM 521; linalool and beta-ionone are selected from Condits chemical engineering (Hubei) Co, and the content of effective substances is 99%; the ethyl maltol is selected from Zhengzhou kernel chemostat products limited company, and the content of effective components is 99 percent; the oxidized isophorone is selected from Huiyi pharmaceutical industry Co., Ltd in Hunan province, and the content of active substances is 97%.

The following are examples of the preparation of tobacco extracts in the present application:

preparation example 1

The specific operation of the deproteinization modification treatment of the tobacco extract in the application is as follows:

drying and crushing tobacco leaves to 60 meshes, and performing ultraviolet sterilization to obtain powder A;

adding the powder A into deionized water, performing ultrasonic extraction for 4 hours at the temperature of 60 ℃, and filtering to obtain extract A;

adding sodium hydroxide into the extract A to adjust the pH of the extract A to 12, distilling at 80 ℃, collecting precipitate A and distillate A, adding malic acid into the distillate A to adjust the pH to 4, filtering, collecting filtrate, adding the filtrate into ethyl acetate for extraction, filtering, and collecting extract B; mixing the extract B and the precipitate A uniformly, adding sodium hydroxide to adjust the pH value to 7, finally concentrating the extract B under reduced pressure, and drying at 40 ℃ to obtain the tobacco extract.

Preparation examples 2 to 5

The modified tobacco extracts of preparation examples 2 to 5 were prepared in the same manner as in preparation example 1, except that the amounts of the respective raw materials were different, as shown in Table 1.

TABLE 1 preparation examples 1-5 amounts (unit: g) of respective raw materials of modified tobacco extract

Raw materials	Preparation example 1	Preparation example 2	Preparation example 3	Preparation example 4	Preparation example 5
						Tobacco leaf	100	200	300	400	500
Ethyl acetate	600	1200	1800	2400	3000
						Deionized water	500	600	700	800	900

Preparation example 6

The modified tobacco extract of preparation example 6 was completely the same as the raw material and the blending amount of the modified tobacco extract of preparation example 1, except that the deproteinization modification treatment of the tobacco extract was specifically as follows: drying and crushing tobacco leaves to 60 meshes, and performing ultraviolet sterilization to obtain powder A;

adding sodium hydroxide into the extract A to adjust the pH of the extract A to 12, distilling at 80 ℃, and collecting precipitate A and distillate A; adding malic acid into the distillate A to adjust pH to 4, filtering, collecting filtrate, and mixing the filtrate and the precipitate A to obtain mixture A; adding sodium hydroxide into the mixture A to adjust pH to 7, concentrating the mixture A under reduced pressure, and oven drying at 40 deg.C to obtain tobacco extract.

The following are examples of the preparation of ambergris essence in the present application:

preparation example 7

The preparation of ambergris essence in this application is specifically operated as:

1. according to the mixing amount shown in the table 2, ambergris alcohol and ambergris ether are added into ethanol and stirred to be dissolved to obtain a solution A;

2. adding linalool, oxidized isophorone, ethyl maltol, furanone and beta-ionone into the solution A, and stirring in a closed stirring kettle until the materials are uniformly mixed.

Preparation examples 8 to 11

Preparation examples 8-11 ambergris essence and preparation example 7 have the same preparation method, except that the raw materials are different in composition, and the details are shown in table 2.

TABLE 2 PREPARATION EXAMPLES 7-11 Admixture of materials of ambergris essence (unit: g)

Preparation examples 12 to 16

The ambergris essence prepared in preparation examples 12 to 16 is completely the same as the preparation method of preparation example 9, except that the raw material components are different, and the details are shown in table 3.

TABLE 3 PREPARATION EXAMPLE 12-16 Each raw material addition amount (unit: g) of ambergris essence

Preparation example 17

The preparation operation of the isatis root extract in the application is as follows: mixing isatis root with 60% ethanol according to the mass concentration of 1: 8, uniformly mixing the components in a weight ratio, and standing for 4 hours to obtain an isatis root extracting solution; placing the obtained radix Isatidis extract on macroporous resin adsorption column, washing macroporous resin adsorption column with deionized water until effluent is colorless, eluting with 80% ethanol, collecting eluate, filtering, collecting residue, and oven drying to obtain radix Isatidis extract.

Example 1

An atomized liquid with ambergris fragrance is prepared by the following operation steps:

weighing the ambergris essence prepared in the preparation example 7 for later use;

weighing the tobacco extract, propylene glycol, glycerin, xylitol and the isatis root extract prepared in the preparation example 1, uniformly mixing to prepare mother liquor;

adding ambergris essence into the mother liquor, stirring, dissolving the raw materials completely, and aging for 25 hr to obtain atomized liquid with ambergris fragrance.

Examples 2 to 5

The atomized liquids of examples 2 to 5 were prepared in the same manner and in the same types as in example 1, except that the amounts of the respective raw materials were different, and the details are shown in table 4.

TABLE 4 amount of each raw material (unit: g) of atomized liquid of examples 1 to 5

Examples 6 to 10

The atomized liquids of examples 6 to 10 were prepared in the same manner and in the same types as in example 4, except that the amounts of the respective raw materials were different, as shown in table 5.

TABLE 5 amount of each raw material of atomized liquid of examples 6 to 10 (unit: g)

Examples 11 to 15

The atomized liquids of examples 11 to 15 were prepared in the same manner and in the same types as those of the raw materials of example 8, except that the tobacco extracts prepared in preparation examples 2 to 6 were selected as the raw materials, and the other raw materials and the amounts added were the same as those of example 8.

Example 16

The atomized liquid of example 16 was prepared in exactly the same manner as in example 12, except that: ambergris ether is not added in the ambergris essence raw materials, and the other raw materials and the mixing amount are the same as those in the example 12.

Examples 17 to 25

The preparation methods and the types of the raw materials of the atomized liquids of the embodiments 17 to 25 are completely the same as those of the embodiment 12, except that the ambergris essence prepared in the preparation examples 8 to 16 is selected as the raw material, and the other raw materials and the mixing amount are the same as those of the embodiment 12. Comparative example 1

The atomized liquid of comparative example 1 was prepared in exactly the same manner as in example 2, except that: xylitol is not added in the raw materials, and the other raw materials and the mixing amount are the same as those in the example 2.

Comparative example 2

The atomized liquid of comparative example 2 was prepared in exactly the same manner as in example 2 except that: the modification treatment operation for removing protein from tobacco extract is as follows: drying and crushing tobacco leaves, adding the tobacco leaves into deionized water, carrying out ultrasonic extraction, filtering, collecting extract liquor, carrying out reduced pressure concentration on the extract liquor, and drying to obtain the tobacco extract.

Comparative example 3

The atomized liquid of comparative example 3 was prepared in exactly the same manner as in example 2, except that: the tobacco extract was not added to the raw materials, and the other raw materials and the blending amount were the same as in example 2.

Comparative example 4

The atomized liquid of comparative example 4 was prepared in exactly the same manner as in example 2, except that: the isatis root extract was not added to the raw materials, and the other raw materials and the blending amount were the same as in example 2.

Performance detection

The atomized liquids obtained in examples 1 to 25 and comparative examples 1 to 4 were added to an electronic atomizer, and the atomized liquids were subjected to flavor and sensory evaluation by the following methods: selecting more than 20 smokers with the age of more than 10 years, referring to the table 10-14 of the aroma and sensory evaluation table of each person, smoking the atomized liquid by using a three-stage smoking evaluation method in a dark evaluation scoring mode, and comprehensively scoring the aroma and sensory quality of the atomized liquid by using a percentage scoring method according to the three-stage scoring tables of the initial stage, the middle stage and the tail stage in the table 6 and the sensory indexes and grade classification scoring tables of the tables 7-9.

TABLE 6 three-stage score distribution chart for evaluation

TABLE 7 sensory index and grade classification and scoring table

TABLE 8 sensory index and grade classification and scoring table

TABLE 9 sensory index and grade classification and scoring table

TABLE 10 fragrance and sensory evaluation tables for different atomized liquids

TABLE 11 fragrance and sensory evaluation tables for different atomized liquids

TABLE 12 fragrance and sensory evaluation tables for different atomized liquids

TABLE 13 fragrance and sensory evaluation tables for different atomized liquids

TABLE 14 fragrance and sensory evaluation tables for different atomized liquids

As can be seen from tables 10 to 14, the atomized liquid with ambergris fragrance has fragrance and sensory index scores which are generally higher than those of comparative examples 1 to 4, and has good mouthfeel and smell, the atomized liquids of examples 1 to 25 have throat entrance scores of 11 to 20, the atomized liquids of comparative examples 1 to 4 have throat entrance scores of 9 to 12, the atomized liquids of examples 1 to 25 have throat entrance scores which are obviously higher than those of the atomized liquids of comparative examples 1 to 4, and the uncomfortable feeling of the throat of a smoker in the smoking process is obviously relieved. In addition, the atomized liquid has higher reduction degree of ambergris fragrance.

In examples 1 to 5, the atomized liquid of example 3 generally showed scores of smell, nasal sensation, mouth smell, flavor and mouth feel higher than those of the atomized liquids of examples 1 to 2 and examples 4 to 5, wherein the degrees of recognition of flavor and aroma were as high as 21 and 5, respectively, and it was found that the atomized liquid of example 3 was more suitable for the preparation of atomized liquids.

In examples 6 to 10, the atomized liquid of example 7 had 10, 8, and 9 minutes of mouth smell, throat feeling, and nasal feeling, which were significantly higher than those of examples 6 and 8 to 10, indicating that when the weight ratio of glycerin to xylitol in the raw material of the atomized liquid was 1:1.2, the throat feeling and nasal feeling were improved, and the atomized liquid had excellent smell and taste.

In examples 11 to 14, the atomized liquid of example 12 had higher flavor and fragrance perceptions of 29 points and 5 points than the atomized liquids of examples 11 and 13 to 14, indicating that the tobacco extract prepared in preparation example 3 was more suitable for preparing atomized liquids and had a more pronounced ambergris fragrance. Example 15 the nebulised liquid had a flavour of 12 which was lower than that of examples 11 to 14, indicating that the flavour of the nebulised liquid was effectively enhanced by the second extraction of the filtrate with ethyl acetate. The fragrance of the atomized liquid in example 16 is 21 minutes, which is generally lower than that of the atomized liquid in example 13, and shows that the ambergris ether added in the ambergris essence improves the mouth feel of smokers and the fragrance of ambergris, and improves the residual feeling of the fragrance of ambergris.

The atomized liquid of example 18 had a residual feeling of 10 minutes, which was higher than those of the atomized liquids of examples 17 and 19 to 20, indicating that the atomized liquid prepared in preparation example 8 had more suitable weight parts of the respective raw materials and exhibited an excellent residual feeling of flavor.

In examples 21 to 25, the throat-entering feeling of example 22 was 20 minutes, the mouth feeling was 14 minutes, and the residual feeling was 10 minutes, which were higher than those of examples 21 and 23 to 25, indicating that when the weight ratio of ambroxol to ambroxol ether in the ambrox essence raw material was 1:4, the ambrox fragrance of the atomized liquid was more stable, and the problems of dry mouth and sore throat after inhalation of the smoke of the atomized liquid were also improved.

Through evaluation of the fragrance and sense of the atomized liquid in the proportion of 1 to 4, the atomized liquid added with xylitol and the isatis root extract can improve the throat feeling and nasal feeling of smokers, and the tobacco extract is added and deproteinized to improve the tobacco extract, so that the fragrance of ambergris is greatly improved, and the demands of the smokers on the sense and the taste of the atomized liquid are met.

The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.

Claims

1. The atomized liquid with ambergris fragrance is characterized by being prepared from the following raw materials in parts by weight: 45-65 parts of propylene glycol, 41-55 parts of glycerol, 3-7 parts of xylitol, 12-16 parts of ambergris essence, 0.3-0.7 part of tobacco extract and 2-6 parts of isatis root extract; the tobacco extract is subjected to deproteinization modification treatment.

2. The atomized liquid with ambergris fragrance according to claim 1, which is prepared from the following raw materials in parts by weight: 50-55 parts of propylene glycol, 44.5-51.5 parts of glycerol, 4-6 parts of xylitol, 13-15 parts of ambergris essence, 0.4-0.6 part of tobacco extract and 3-5 parts of isatis root extract.

3. The atomized liquid with ambergris aroma according to claim 1, wherein the tobacco extract is extracted from the following raw materials in parts by weight: 1-5 parts of tobacco leaves, 5-9 parts of deionized water and 6-30 parts of ethyl acetate.

4. The atomized liquid with ambergris aroma according to claim 3, wherein the deproteinization modification treatment operation of the tobacco extract is as follows: drying and crushing tobacco leaves, adding the tobacco leaves into deionized water, carrying out ultrasonic extraction, adjusting the pH value to 10-13, distilling, and collecting a precipitate A and a distillate A; adjusting the pH of the distillate A to 3-5, filtering, collecting the filtrate, extracting the filtrate with ethyl acetate, filtering, and collecting the extract B; mixing the extractive solution B and the precipitate A uniformly, adjusting pH to 6-8, concentrating under reduced pressure, and oven drying to obtain tobacco extract.

5. The atomized liquid with ambergris fragrance according to claim 1, wherein the ambergris essence is prepared from the following raw materials in parts by weight: 1-3 parts of ambroxol, 0.4-0.5 part of ambroxol, 0.01-0.03 part of linalool, 0.05-0.07 part of oxidized isophorone, 0.5-0.7 part of ethyl maltol, 0.04-0.06 part of beta-ionone, 0.04-0.06 part of furanone and 5-7 parts of ethanol.

6. The aerosolized liquid with ambergris fragrance of claim 5, wherein: the weight ratio of ambergris alcohol to ambergris ether is 1: (3-5).

7. The aerosolized liquid with ambergris fragrance of claim 1, wherein: the weight ratio of the glycerol to the propylene glycol is 1: (1.1-1.3).

8. A method for preparing the atomized liquid with ambergris fragrance as in any one of claims 1 to 7, which is characterized by comprising the following steps:

weighing ambergris essence for later use;