CN114304714B - Electronic cigarette liquid and preparation method thereof - Google Patents

Abstract

The application provides an electronic cigarette tobacco juice, the electronic cigarette tobacco juice comprises hyaluronic acid or salt thereof and gamma-aminobutyric acid, the problem that the hyaluronic acid or salt thereof easily blocks a tobacco core of an electronic cigarette is solved, the atomization effect of active ingredients such as the hyaluronic acid or salt thereof is improved, the moisturizing effect of the electronic cigarette tobacco juice is enhanced, and meanwhile, the aroma-generating ingredients in the tobacco juice have the aroma-protecting effect. The application also provides a preparation method of the electronic cigarette liquid.

Description

Electronic cigarette liquid and preparation method thereof

Technical Field

The invention relates to the technical field of novel tobacco, in particular to electronic cigarette liquid and a preparation method thereof.

Background

Smoking is harmful, not only is human health harmful, but also has adverse effects on society. Smoking has the greatest harm to respiratory tracts, chronic bronchitis can be caused by long-term smoking, obstructive emphysema can be caused by tobacco tar which is adsorbed on alveoli to influence the expansion of the alveoli, and patients can present chronic cough and expectoration with short breath in clinical symptoms at ordinary times. Smoking also has an adverse effect on teeth, and data show that smokers have as many as three times as many periodontitis as non-smokers, while heavy smokers can be as high as seven times. Periodontitis is a disease occurring in periodontal tissues, and is a chronic inflammation that attacks tissues such as gingiva, periodontal pockets, periodontal ligament and alveolar bone, in which halitosis, gingival bleeding and gingival swelling are typical symptoms of periodontal disease. In China, the incidence rate of adult periodontitis reaches 80% -90%, and the incidence rate also increases with the age. Smoking can promote the occurrence of periodontal diseases and aggravate the conditions of periodontal diseases. Modern oral medicine research also proves that nicotine chemical stimulation, temperature stimulation and the like during smoking firstly cause damage to the oral cavity, and smoking also obviously reduces the amount of immunoglobulin in saliva and greatly reduces local resistance, thereby causing various oral diseases.

In order to reduce the harm of smoking to human body itself and other people and environment, a novel tobacco product is provided. The novel tobacco products can be divided into three main categories: electronic cigarettes, heat non-combustible tobacco products, and smokeless tobacco products.

The electronic cigarette liquid, as a key part of the electronic cigarette, determines the aroma, the fragrance, the comfort and the satisfaction of electronic cigarette smoking, and also determines other potential efficacies of the electronic cigarette. At present, the electronic cigarette liquid in the market mainly takes aroma, fragrance and taste as main directions, and other potential effects cannot be provided. Meanwhile, acids, aldehydes, phenols, alcohols and other substances contained in the electronic cigarette liquid are easy to cause symptoms such as dry throat, throat itching, irritable cough, chronic pharyngitis and the like. Therefore, there is a strong need to add active ingredients to e-cigarette smoke liquids to achieve smoking comfort and pleasure while reducing the harm caused by smoking and second-hand smoke.

Hyaluronic Acid (HA), also known as hyaluronic acid, is a disaccharide glycosaminoglycan composed of D-glucuronic acid and N-acetylglucosamine, and is a major component constituting connective tissues such as human intercellular substance, ocular vitreous body, synovial fluid of joints, etc., and plays important physiological roles of water retention, extracellular space maintenance, osmotic pressure regulation, lubrication, and cell repair promotion in vivo. Hyaluronic acid molecules contain a large amount of carboxyl and hydroxyl, and hydrogen bonds in molecules and among molecules are formed in an aqueous solution, so that the hyaluronic acid has a strong water retention effect, can be combined with thousands of times of water per se, and can be understood that hyaluronic acid with higher molecular weight has higher water retention within a certain range.

However, the electronic cigarette liquid added with hyaluronic acid, especially hyaluronic acid with relatively high molecular weight, is easy to block the cigarette core, damage the electronic cigarette and cause smoking difficulty.

Disclosure of Invention

In order to solve the technical problems in the prior art, the invention provides an electronic cigarette liquid added with hyaluronic acid or a salt thereof and gamma-aminobutyric acid and a preparation method thereof, wherein the electronic cigarette liquid generates aerosol for a user to inhale through an atomization device, and the hyaluronic acid or the salt thereof and the gamma-aminobutyric acid in the electronic cigarette liquid can be heated and atomized together with the cigarette liquid to play the effects of relieving anxiety, reducing blood pressure, improving brain activity, promoting ethanol metabolism and the like by designing the molecular weight of the hyaluronic acid or the salt thereof and adjusting the mass ratio of the hyaluronic acid or the salt thereof to the gamma-aminobutyric acid, so that the blockage of the hyaluronic acid or the salt thereof on a cigarette core of the electronic cigarette is avoided; meanwhile, the moisture retention of the hyaluronic acid or the salt thereof can effectively reduce the dryness and the irritation of the electronic cigarette aerosol, and improve symptoms of dry throat, throat itching, irritative cough, chronic pharyngitis and the like caused by smoking; in addition, the addition of hyaluronic acid or the salt thereof can improve the aroma-keeping performance of the electronic cigarette liquid.

The technical scheme of the invention is as follows:

1. an electronic cigarette liquid comprising hyaluronic acid or a salt thereof and gamma-aminobutyric acid;

preferably, the molecular weight of the hyaluronic acid or salt thereof is 55-200kDa, preferably 55-80kDa.

2. The electronic cigarette liquid according to item 1, wherein the hyaluronic acid or the salt thereof is 0.005-1.5 wt% and the gamma-aminobutyric acid is 0.005-10 wt% of the total weight of the electronic cigarette liquid;

preferably, the hyaluronic acid or the salt thereof accounts for 0.01-0.1 wt% and the gamma-aminobutyric acid accounts for 0.01-5 wt% of the total weight of the electronic cigarette liquid.

3. The electronic cigarette liquid of item 1, further comprising a plant extract and an adjuvant;

preferably, the plant extract accounts for 1-30 wt%, preferably 5-30 wt% of the total weight of the electronic cigarette liquid;

more preferably, the plant extract is one or more selected from sweet orange oil, orange extract, green tea extract, coffee extract and lemon oil.

4. The e-cigarette liquid of item 3, the adjuvant selected from at least one of glycerin, propylene glycol, nicotine, and water;

preferably, the glycerol accounts for 20-80 wt%, the propylene glycol accounts for 5-60 wt%, and the nicotine accounts for 0-5 wt% of the total weight of the electronic cigarette liquid;

further preferably, the nicotine is 1-5wt%.

5. The electronic cigarette liquid according to item 4, wherein the nicotine is nicotine alkali or nicotine salt, and the hyaluronate is one or more of sodium salt, potassium salt, calcium salt and zinc salt.

6. A preparation method of electronic cigarette liquid comprises the following steps:

stirring and mixing the auxiliary materials, and completely dissolving to obtain a component A;

stirring and mixing water and hyaluronic acid or salt thereof, and dissolving completely to obtain a component B;

adding plant extract and gamma-aminobutyric acid into the component B, and completely dissolving to obtain a component C;

and stirring and mixing the component C and the component A to obtain the electronic cigarette liquid.

7. The preparation method according to item 6, wherein the hyaluronic acid or the salt thereof is 0.005-1.5 wt% and the gamma-aminobutyric acid is 0.005-10 wt% of the total weight of the electronic cigarette liquid;

preferably, the hyaluronic acid or the salt thereof accounts for 0.01-0.1 wt% and the gamma-aminobutyric acid accounts for 0.01-5 wt% of the total weight of the electronic cigarette liquid.

8. The production method according to item 6, wherein the molecular weight of the hyaluronic acid or a salt thereof is 55 to 200kDa, preferably 55 to 80kDa.

9. The preparation method according to item 6, wherein the plant extract accounts for 1-30 wt%, preferably 5-30 wt% of the total weight of the electronic cigarette liquid;

more preferably, the plant extract is one or more selected from sweet orange oil, orange extract, green tea extract, coffee extract and lemon oil.

10. The production method according to the above-mentioned item 6,

the auxiliary material is at least one selected from glycerol, propylene glycol, nicotine and water;

preferably, the glycerol accounts for 20-80 wt%, the propylene glycol accounts for 5-60 wt%, and the nicotine accounts for 0-5 wt% of the total weight of the electronic cigarette liquid;

further preferably, the nicotine is 1-5wt%.

Compared with the prior art, the invention has the technical effects that:

(1) According to the invention, through the compounding of the hyaluronic acid or the salt thereof with the specific molecular weight and the gamma-aminobutyric acid, the problem that the hyaluronic acid or the salt thereof is easy to block the electronic cigarette core can be solved, and the atomization effect of the hyaluronic acid or the salt thereof and other active ingredients is improved, so that the hyaluronic acid or the salt thereof is better absorbed by a human body in an atomization mode, the symptoms of dry throat, throat itching, irritable cough, chronic pharyngitis and the like caused by smoking are improved, and the health care effects of the hyaluronic acid or the salt thereof and the gamma-aminobutyric acid are exerted.

(2) According to the electronic cigarette liquid provided by the invention, the bioactive components of hyaluronic acid or salt thereof and gamma-aminobutyric acid are added into the electronic cigarette liquid, so that the moisturizing effect of the electronic cigarette liquid is enhanced, and meanwhile, the electronic cigarette liquid has a fragrance preserving effect on the fragrant components in the liquid.

(3) The electronic cigarette liquid provided by the invention utilizes the plant extract to replace essence as a fragrance component, and the alkaloid contained in the electronic cigarette liquid improves the taste of the electronic cigarette without adding nicotine to a certain extent, and improves the safety and environmental protection of smoking the electronic cigarette.

(4) The hyaluronic acid and the gamma-aminobutyric acid selected by the invention are prepared by microbial fermentation, the plant extracts are obtained by adopting physical process extraction, and the high-purity pharmaceutical grade product is obtained by multi-step purification, so that the safety experience of consumers is greatly ensured.

Detailed Description

The present invention will be described in detail below with reference to embodiments, however, it should be understood that the present invention may be embodied in various forms and should not be limited by the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

It should be noted that certain terms are used throughout the description and claims to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. This specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to. The description which follows is a preferred embodiment of the invention, however, it is to be understood that the general principles of the description are not to be taken in a limiting sense. The scope of the present invention is defined by the appended claims.

The invention provides electronic cigarette liquid which comprises hyaluronic acid or salt thereof and gamma-aminobutyric acid.

Hyaluronic acid or its salt hyaluronic acid is a straight-chain macromolecular acidic mucopolysaccharide composed of D-glucuronic acid and N-acetylglucosamine disaccharide unit, also called hyaluronic acid, which is widely present in human bodies, animals and microorganisms, has no species specificity, is nontoxic, has no irritation, has good biocompatibility and has high safety. The hyaluronic acid has the properties of water retention, lubrication, no sensitization and the like, and hyaluronic acid molecules can absorb and retain thousands of times of water by weight of the hyaluronic acid molecules, so that the hyaluronic acid is the substance which is found to have the best moisture retention in nature at present and is called as an ideal natural moisture retention factor. Hyaluronic acid plays a major role in regulating fluid balance of the pulmonary interstitium, and existing studies also emphasize the key role played by hyaluronic acid and its degradation products in the physiology and pathology of the respiratory system. The hyaluronic acid is usually hyaluronic acid, a hyaluronate salt, or a combination thereof, and the hyaluronate salt can be sodium salt, potassium salt, calcium salt, zinc salt and the like of hyaluronic acid. Hyaluronic acid or a salt thereof has different effects depending on its molecular weight. It is known that hyaluronic acid or a salt thereof with a smaller molecular weight, such as hyaluronic acid with a molecular weight of less than 10kDa, has better solubility, is not easy to block a cigarette core, and is widely applied in electronic cigarette liquid, but has a lower molecular weight, poor moisture and fragrance retention effects, and when the molecular weight is less than 10kDa, a part of hyaluronic acid or a salt thereof can be cracked at a high temperature, and the hyaluronic acid structure is not retained any more, so that the efficacy is reduced; although hyaluronic acid or a salt thereof with relatively high molecular weight has more obvious moisturizing and aroma-keeping effects, the hyaluronic acid with relatively high molecular weight is easy to block a cigarette core when being used alone, so that the service life of the electronic cigarette is shortened, and the user experience is shortened, thereby limiting the application of the hyaluronic acid or a salt thereof in the electronic cigarette.

English name of γ -aminobutyric acid: gamma-amino butyric Acid (GABA), chemical name: 4-aminobutyric acid, alternative name: aminobutyric acid, pipecolic acid. Is a non-protein amino acid widely distributed in animal and plant bodies, is an important inhibitory neurotransmitter of the central nervous system, has good water solubility and thermal stability, plays an irreplaceable role in regulating the vital activities of organisms, and is also known as a natural anti-aging factor. When GABA is deficient in a human body, negative emotions such as anxiety, uneasiness, tiredness, anxiety and the like are generated. The health department of 2009 approved aminobutyric acid as a new food raw material, and research shows that supplementing exogenous GABA has physiological effects of tranquilizing nerves, relieving anxiety, reducing blood pressure, improving brain activity, promoting ethanol metabolism, slowing down skin aging, and the like.

In addition, the atomization temperature of the conventional electronic cigarette is 200-500 ℃, and molecular components such as saccharides and glycosides cannot be volatilized into smoke gas, so that the effect is limited. Only by selecting the substances with the boiling point below 500 ℃, the substances can be atomized into the smoke, thereby generating the functions of fragrance enhancement and pharmacological activity. When natural active ingredients with functions are screened, not only the pharmacological activity of the molecular ingredients is considered, but also the smoking sensory feeling, the comfort, the flavor enhancement effect and the taste effect of the active substances volatilized into smoke are considered.

The experimental research shows that the compounding of hyaluronic acid or salt thereof and gamma-aminobutyric acid can solve the problem that hyaluronic acid or salt thereof with high molecular weight is easy to block the cigarette core of the electronic cigarette, and improves the atomization effect of the hyaluronic acid or salt thereof and other active ingredients, so that the hyaluronic acid or salt thereof can be better absorbed by a human body in an atomization form, damaged cells in oral cavity and respiratory tract can be repaired, and the symptoms of dry throat, throat itching, irritable cough, chronic pharyngitis and the like caused by smoking can be improved based on the strong moisture retention of the hyaluronic acid or salt thereof, and the compound hyaluronic acid or salt thereof has a relatively obvious health care effect on a respiratory system.

In some embodiments of the invention, the molecular weight of the hyaluronic acid or salt thereof is between 55-200kDa, preferably between 55-80kDa.

For example, the molecular weight of hyaluronic acid or salt thereof may be 55, 60, 70, 80, 90, 100, 110, 120, 130, 145, 150, 160, 170, 180, 190, 200kDa, or any range therebetween.

In some embodiments of the invention, the hyaluronic acid or salt thereof is 0.005-1.5 wt% and the gamma-aminobutyric acid is 0.005-10 wt% of the total weight of the electronic cigarette liquid;

preferably, the hyaluronic acid or the salt thereof accounts for 0.01-0.1 wt% and the gamma-aminobutyric acid accounts for 0.01-5 wt% of the total weight of the electronic cigarette liquid;

for example, the hyaluronic acid or salt thereof may be 0.005, 0.01, 0.02, 0.03, 0.04, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5wt%, or any range therebetween, based on the total weight of the e-cigarette liquid;

the gamma-aminobutyric acid may be 0.005, 0.01, 0.02, 0.03, 0.04, 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2.0, 3.0, 4.0, 5.0, 6.0, 7.0, 8.0, 9.0, 10wt% or any range therebetween.

In some embodiments of the invention, the electronic cigarette liquid further comprises a plant extract and an adjuvant;

preferably, the plant extract accounts for 1-30 wt%, preferably 5-30 wt% of the total weight of the electronic cigarette liquid;

for example, the plant extract may be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30wt% or any range therebetween, based on the total weight of the e-cigarette liquid.

In some embodiments of the present invention, the plant extract is selected from one or more of sweet orange oil, orange extract, green tea extract, coffee extract, lemon oil.

The plant extract replaces essence to be used as a fragrance component, and meanwhile alkaloid in the plant extract can provide better smoking feeling for the electronic cigarette without adding nicotine.

The hyaluronic acid or the salt thereof, the gamma-aminobutyric acid and the plant extract are medicinal raw materials. Hyaluronic acid or its salts, gamma-aminobutyric acid and plant extracts can be prepared by various now-reported techniques. The hyaluronic acid or the salt thereof and the gamma-aminobutyric acid are preferably prepared by a microbial fermentation method; the plant extract is preferably extracted by physical process, so that the obtained product has high safety.

In some embodiments of the invention, the adjuvant is selected from at least one of glycerol, propylene glycol, nicotine, and water;

wherein, based on the total weight of the electronic cigarette liquid, the glycerol accounts for 20-80 wt%, the propylene glycol accounts for 5-60 wt%, and the nicotine accounts for 0-5 wt%; preferably, the nicotine is 1-5wt%;

for example, the glycerin may be 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80wt%, or any range therebetween, based on the total weight of the e-liquid;

the propylene glycol is 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60wt% or any range therebetween;

the nicotine is 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5wt% or any range therebetween.

The nicotine in the invention is a natural alkaloid extracted from tobacco leaves or other plants containing nicotine, is an important substance causing addiction to smokers, and is small in amount and not carcinogenic. Nicotine is often nicotine base, nicotine salt or a combination of both. The electronic cigarette liquid of the invention can contain a small amount of nicotine or not.

The glycerin and the propylene glycol are used as common components of the electronic cigarette smoke agent and carriers of various effective components, so that the smoking taste can be improved, and the glycerin and the propylene glycol are food-grade raw materials.

In some embodiments of the present invention, the nicotine is nicotine base or nicotine salt, and the hyaluronic acid salt is selected from one or more of sodium salt, potassium salt, calcium salt and zinc salt.

The invention selects deionized water as a solvent for dissolving hyaluronic acid and gamma-aminobutyric acid, and the dosage of the deionized water can be adjusted according to the content of hyaluronic acid and gamma-aminobutyric acid. Within the above range of the content of hyaluronic acid or a salt thereof, the balance is water, and for example, the content of water may be selected from 0.05 to 10wt%. Preferably 0.05 to 6wt%.

The invention provides a preparation method of the electronic cigarette liquid, which comprises the following steps:

stirring and mixing the auxiliary materials, and completely dissolving to obtain a component A;

stirring and mixing water and hyaluronic acid or salt thereof, and dissolving completely to obtain a component B;

adding plant extract and gamma-aminobutyric acid into the component B, and completely dissolving to obtain a component C;

and stirring and mixing the component C and the component A to obtain the electronic cigarette liquid.

In some embodiments of the invention, the method comprises the following steps:

mixing glycerol, propylene glycol and/or nicotine, stirring, and ultrasonically dissolving to obtain component A;

mixing water and hyaluronic acid or its salt, heating, stirring, and ultrasonically dissolving to obtain component B;

mixing gamma-aminobutyric acid, plant extract and the component B, and performing dissolution assistance by adopting stirring and ultrasonic waves to obtain a component C;

and adding the component C into the component A, stirring, and ultrasonically mixing uniformly to obtain the electronic cigarette liquid.

In the above steps, the stirring speed is 200-500 rpm. For example, 200rpm, 220rpm, 250rpm, 280rpm, 300rpm, 320rpm, 350rpm, 370rpm, 390rpm, 400rpm, 450rpm, 460rpm, 480rpm, 500rpm, and in some embodiments, 350rpm.

In the above step, the component B is heated in the stirring and dissolving process.

In some embodiments of the invention, the temperature is 40-65 ℃, for example, 40 ℃, 42 ℃, 45 ℃, 47 ℃, 48 ℃, 49 ℃, 50 ℃, 52 ℃, 54 ℃, 56 ℃, 58 ℃,60 ℃, 62 ℃, 63 ℃, 65 ℃, in certain preferred embodiments, the heating temperature is 60 ℃.

In some embodiments of the present invention, in the above preparation method, based on the total weight of the electronic cigarette liquid: 0 to 5 weight percent of nicotine, 0.005 to 1.5 weight percent of hyaluronic acid or salt thereof, 0.005 to 10 weight percent of gamma-aminobutyric acid, 1 to 30 weight percent of plant extract, 20 to 80 weight percent of glycerol, 5 to 60 weight percent of propylene glycol and the balance of water.

In some embodiments of the present invention, in the above preparation method, based on the total weight of the electronic cigarette liquid: 1 to 5 weight percent of nicotine, 0.005 to 0.05 weight percent of hyaluronic acid or salt thereof, 0.005 to 5 weight percent of gamma-aminobutyric acid, 5 to 30 weight percent of plant extract, 20 to 80 weight percent of glycerol, 5 to 60 weight percent of propylene glycol and 0.05 to 6 weight percent of water.

The biological active components of hyaluronic acid or salt thereof and gamma-aminobutyric acid are added into the electronic cigarette liquid provided by the invention, when the molecular weight of hyaluronic acid or salt thereof is 55-200kDa, preferably 55-80kDa, the content is 0.005-1.5 wt%, preferably 0.01-0.1 wt%, and the content of gamma-aminobutyric acid is 0.005-10 wt%, preferably 0.01-5 wt%, the problem that the electronic cigarette core is easily blocked by hyaluronic acid with a higher molecular weight can be solved, the atomization effect of the active components of hyaluronic acid and the like is improved, and therefore, the hyaluronic acid or salt thereof can be better absorbed by a human body in an atomization mode, the symptoms of dry throat, throat itching, irritable cough, chronic pharyngitis and the like caused by smoking are improved, and other health-care effects of hyaluronic acid and gamma-aminobutyric acid can be exerted.

According to the invention, the plant extract is used as a fragrant component instead of essence, and alkaloid contained in the plant extract can replace nicotine to a certain extent to improve the taste of the electronic cigarette, so that the safety and environmental friendliness of smoking the electronic cigarette are improved. Meanwhile, through compounding hyaluronic acid with a specific molecular weight and aminobutyric acid, the cigarette has a fragrance-keeping effect on the fragrant components in the cigarette liquid.

The hyaluronic acid or the salt thereof and the gamma-aminobutyric acid selected by the invention are prepared by microbial fermentation, the plant extracts are obtained by adopting physical process extraction, and the high-purity pharmaceutical grade product is obtained by multi-step purification, so that the safety experience of consumers is greatly ensured.

The invention is described generally and/or specifically for the materials used in the tests and the test methods, in the following examples,% means wt%, i.e. percent by weight, unless otherwise specified. The reagents or instruments used are not indicated by the manufacturer, and are all conventional reagent products commercially available, wherein Table 1 is a source of raw materials used in the examples.

Table 1 sources of raw materials used in the examples

Raw materials	Manufacturer of the product
		Hyaluronic acid sodium salt	BLOOMAGE BIOTECH Co.,Ltd.
Gamma-aminobutyric acid	BLOOMAGE BIOTECH Co.,Ltd.
		Green tea extract	Tekenobao Co Ltd

Example 1

(1) Sequentially adding 50wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine in a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and performing ultrasonic treatment at the rotating speed of 350rpm, and stirring and completely dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 2

(1) And (2) sequentially adding 53wt% of glycerol and 30wt% of propylene glycol in a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and performing ultrasonic treatment at the rotating speed of 350rpm, and stirring and dissolving completely at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 3

(1) Adding 51wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 0.99wt% of deionized water and 0.01wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 4

(1) Adding 48wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring and performing ultrasonic treatment at the rotating speed of 350rpm, and stirring and completely dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 2.5wt% of deionized water and 1.5wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 5

(1) Adding 50wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, sequentially stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 200kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 6

(1) Adding 50wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, sequentially stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 55kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 7

(1) And sequentially adding 54.99wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine in a clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette smoke solution, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 0.01wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 8

(1) Adding 45wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, sequentially stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 10wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 9

(1) Adding 51.1wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 0.895wt% of deionized water and 0.005wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 10

(1) And (2) sequentially adding 47.4wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine in a clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring and performing ultrasonic treatment at the rotating speed of 350rpm, and stirring and completely dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 2.8wt% of deionized water and 1.8wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 11

(1) Adding 50wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, sequentially stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 300kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 12

(1) Sequentially adding 50wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine in a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and performing ultrasonic treatment at the rotating speed of 350rpm, and stirring and completely dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 5kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 13

(1) Adding 55wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, sequentially stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.945wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 0.005wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 14

(1) Adding 43wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette smoke solution, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 12wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Example 15

(1) Adding 49.4wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And sequentially adding 2.1wt% of deionized water and 0.5wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette smoke solution, heating and stirring at 60 ℃, and performing ultrasonic treatment at the rotating speed of 350rpm to completely dissolve the components to obtain the component B.

(3) Mixing 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract with the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Comparative example 1

(1) Adding 55wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine into a clean reaction kettle according to the total weight of the electronic cigarette liquid, sequentially stirring and ultrasonically treating at the rotating speed of 350rpm, and completely stirring and dissolving at room temperature to obtain the component A.

(2) And (3) sequentially adding 1.95wt% of deionized water and 0.05wt% of sodium hyaluronate with the molecular weight of 80kDa into another clean reaction kettle according to the weight percentage based on the total weight of the electronic cigarette liquid, heating and stirring at 60 ℃, performing ultrasonic treatment at the rotating speed of 350rpm, and completely dissolving to obtain the component B.

(3) Mixing 10wt% of green tea extract and the component B according to the weight percentage based on the total weight of the electronic cigarette liquid, stirring, performing ultrasonic treatment, and completely dissolving to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

Comparative example 2

(1) In a clean reaction kettle, based on the total weight of the electronic cigarette liquid, 50.05wt% of glycerol, 30wt% of propylene glycol and 3wt% of nicotine are sequentially added according to weight percentage, stirring and ultrasonic treatment are carried out, the rotating speed is 350rpm, and the components A are completely stirred and dissolved at room temperature to obtain the component A.

(2) In another clean reaction kettle, based on the total weight of the electronic cigarette liquid, adding 5wt% of gamma-aminobutyric acid and 10wt% of green tea extract into 1.95wt% of deionized water according to weight percentage, mixing, stirring and ultrasonically treating the mixture until the mixture is completely dissolved to obtain a component C;

(4) And adding the component C into the component A, starting stirring at the rotation speed of 350rpm for 40min at room temperature to obtain the electronic cigarette liquid.

TABLE 2 Main parameters of examples 1-14 and comparative examples 1-2

Verification example 1 atomization effect of electronic cigarette

(1) The test method comprises the following steps: headspace gas chromatography-mass spectrometry

4m L electronic cigarette liquid is added into a headspace bottle, and the bottle cap is tightly covered. Placing the headspace bottle into a GC-PAL autosampler sample tray, and setting the extraction conditions as follows: keeping the temperature at 80 ℃ for 3min, adsorbing at 80 ℃ for 30min, and rotating the extraction disc at the speed of 250r/min; desorbing the extracted substance at 250 deg.C for 5min.

The GC/MS analysis conditions were:

a chromatographic column: HP-5MS capillary column (30 m.times.0.25 mm.times.0.25 μm); carrier gas: he (purity 99.999%); constant voltage mode: 70kPa; temperature rising procedure:

260 deg.C (2 min); and (3) sample introduction mode: no shunt sampling; sample inlet temperature: 250 ℃; transmission line temperature: 280 ℃; an ionization mode: EI; ionization energy: 70eV; the ion source temperature is 220 ℃; temperature of the quadrupole rods: 160 ℃; scanning mass range: 35-450 amu; solvent retardation: and 2min.

And (3) retrieving detection data through a Nist and Wiley standard spectrum library, analyzing and comparing the detection data with standard spectrum time, determining the components in the smoke, calculating the relative percentage content of sodium hyaluronate and gamma-aminobutyric acid by using a peak area normalization method to obtain the content of sodium hyaluronate and gamma-aminobutyric acid in the smoke, and calculating the atomization efficiency of each embodiment and comparative example.

(2) Atomization effect

TABLE 3 atomization efficiency of main ingredients of examples 1 to 15 and comparative examples 1 to 2

The results show that the embodiment of the invention can effectively improve the atomization effect of hyaluronic acid and gamma-aminobutyric acid with higher molecular weight and improve the atomization efficiency of effective components through the reasonable compounding of sodium hyaluronate with specific molecular weight and gamma-aminobutyric acid, thereby better exerting the effects of health care, moisture preservation and fragrance preservation.

As can be seen from comparison among examples 1, 3, 4, 7, 8, 9, 10, 13, 14, and 15, the combination of sodium hyaluronate and γ -aminobutyric acid in a specific ratio can improve the atomization effect of sodium hyaluronate and γ -aminobutyric acid, and the atomization effect is better when the content of hyaluronic acid is 0.005% -1.5% and the content of γ -aminobutyric acid is 0.01% -10%, and especially the atomization effect is best when the content of hyaluronic acid is 0.01% -0.1% and the content of γ -aminobutyric acid is 0.1% -5%.

As can be seen from comparison of examples 1, 3, 4, 9, 10, and 15, when the content of sodium hyaluronate is varied within a certain range (0.005-0.05%) at a specific ratio, the increase in the content does not reduce the atomization effect of sodium hyaluronate, but when the content of sodium hyaluronate is further increased, the atomization effect is significantly reduced.

Verification example 2 electronic cigarette sensory evaluation

The electronic cigarette smoke liquids of examples 1-15 and comparative examples 1-2 of the invention were used as smoking evaluation samples.

(1) The smoking method comprises the following steps:

11 sensory evaluation indexes are set, namely aroma, concentration, aftertaste, miscellaneous gas, fine and greasy feeling, smoking amount and stability.

15 technical experts for smoking evaluation are set, an integral circulation smoking evaluation method is adopted, sensory evaluation standards are set according to different weights and are divided into five grades, and the details are shown in table 4.

TABLE 4 sensory evaluation criteria

According to the index scale and weight setting in table 4, the number of the first 5, the number of the middle 5 and the number of the last 5 are selected for evaluation of each sensory index, the minimum scoring unit is 1 point, and the evaluation result is recorded.

(1) And (4) evaluating the result of smoking:

and (4) counting results: calculating the single term average score according to the formula (1), and the result is accurate to 0.1; the sensory quality score is expressed as the sum of the individual mean scores according to equation (2) to the nearest 0.1 point.

Sigma Xi … … … … … … a sum of scores of one-item sensory index

number of persons participating in evaluation of n … … … … … … …

… … … … … … some single term average score

ZG＝∑Xi……………………(2)

The sum of the average scores of the single items of ZG … … … … … … … … is the sensory comprehensive score of the electronic cigarette

The results are detailed in Table 5.

TABLE 5 sensory evaluation results of examples 1 to 15 and comparative examples 1 to 2

As can be seen from the comparison of examples 1, 3, 4, 9, 10 and 15, the sensory score of the electronic cigarette liquid increases first and then decreases with the increase of the content of sodium hyaluronate in a certain content range of sodium hyaluronate under a specific proportion of gamma-aminobutyric acid.

As can be seen from comparison among examples 1, 7, 8, 13 and 14, when 0.05wt% of sodium hyaluronate is selected, the sensory effect of the electronic cigarette liquid changes in a parabolic manner along with the increase of the content of gamma-aminobutyric acid within a certain content range, and the optimal sensory effect is obtained when the content of gamma-aminobutyric acid is 5wt%.

According to the embodiment of the invention, the sensory effect of the electronic cigarette is improved by reasonably proportioning the sodium hyaluronate with the specific molecular weight and the gamma-aminobutyric acid.

Verification example 3 fragrance-retaining effect of electronic cigarette

The electronic cigarette liquid of examples 1-15 and comparative examples 1-2 of the invention was used as an evaluation sample.

The tobacco juice normally left for 6, 12 and 18 months is subjected to sensory evaluation according to the evaluation method and standard of the verification example 2. The evaluation index is the aroma.

The aroma-maintaining effects of examples 1 to 15 and comparative examples 1 to 2 were calculated according to the formula (2)

The evaluation results are shown in Table 6.

TABLE 6 fragrance-keeping effect of electronic cigarettes of examples 1-15 and comparative examples 1-2

As can be seen from table 6, in a certain range, as the molecular weight and the addition amount of the sodium hyaluronate are increased, the fragrance preserving effect of the electronic cigarette liquid is also improved, and especially, the long-term fragrance preserving effect of the electronic cigarette liquid is more influenced. However, when the molecular weight and the addition amount of the sodium hyaluronate reach a certain degree, the influence of continuously increasing the molecular weight or the content on the aroma-keeping effect is weakened, and the atomization effect of the tobacco juice is influenced by higher molecular weight and the addition amount, so that multiple factors are comprehensively considered.

As can be seen from the above experiments, the smoking sensation of the examples of the present invention is more comfortable. According to the invention, sodium hyaluronate with a specific molecular weight range and gamma-aminobutyric acid are added into the cigarette liquid of the electronic cigarette according to a certain proportion, so that the electronic cigarette has good fragrance and aftertaste, the situation that the cigarette core of the electronic cigarette is blocked by sodium hyaluronate with a higher molecular weight is avoided, the taste of the electronic cigarette is improved, the synergistic effect is exerted, and the plant extract as a natural fragrance component has the effects of fragrance retention and fragrance fixation. The electronic cigarette liquid disclosed by the invention is strong in fragrance, fine and smooth in taste and comfortable to suck, solves the common problem that the cigarette core is blocked by sodium hyaluronate with a relatively high molecular weight, and has various health-care effects on a human body.

Although the present disclosure has been described with reference to particular embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present disclosure, and the scope of the present disclosure should be limited only by the terms of the appended claims.

Claims (19)

1. An electronic cigarette liquid, which is characterized by comprising hyaluronic acid or a salt thereof and gamma-aminobutyric acid;

the molecular weight of the hyaluronic acid or the salt thereof is 55-200kDa;

based on the total weight of the electronic cigarette liquid, the hyaluronic acid or the salt thereof is 0.005 to 1.5wt%, and the gamma-aminobutyric acid is 0.005 to 10wt%.

2. The electronic cigarette liquid of claim 1, wherein the hyaluronic acid or the salt thereof is 0.01 to 0.1wt% and the gamma-aminobutyric acid is 0.01 to 5wt% based on the total weight of the electronic cigarette liquid.

3. The e-cigarette liquid of claim 1,

the molecular weight of the hyaluronic acid or the salt thereof is 55-80kDa.

4. The e-cigarette liquid of claim 1, further comprising a botanical extract and an adjuvant.

5. The e-cigarette liquid of claim 4,

the plant extract accounts for 1 to 30wt% of the total weight of the electronic cigarette liquid.

6. The e-cigarette liquid of claim 5,

the plant extract accounts for 5-30wt% of the total weight of the electronic cigarette liquid.

7. The e-cigarette liquid of claim 4,

the plant extract is selected from one or more of sweet orange oil, orange extract, green tea extract, coffee extract, and lemon oil.

8. The e-liquid of claim 4, wherein the adjuvant is selected from at least one of glycerin, propylene glycol, nicotine, and water.

9. The e-cigarette liquid of claim 8,

based on the total weight of the electronic cigarette liquid, the glycerol accounts for 20-80wt%, the propylene glycol accounts for 5-60wt%, and the nicotine accounts for 0-5wt%.

10. The e-cigarette liquid of claim 9,

the nicotine accounts for 1-5wt% of the total weight of the electronic cigarette liquid.

11. The electronic cigarette liquid of claim 8, wherein the nicotine is nicotine base or nicotine salt, and the hyaluronic acid salt is one or more selected from sodium salt, potassium salt, calcium salt and zinc salt.

12. A preparation method of electronic cigarette liquid comprises the following steps:

stirring and mixing the auxiliary materials, and completely dissolving to obtain a component A;

stirring and mixing water and hyaluronic acid or salt thereof, and dissolving completely to obtain a component B;

adding plant extract and gamma-aminobutyric acid into the component B, and completely dissolving to obtain a component C;

stirring and mixing the component C and the component A to obtain electronic cigarette liquid;

the molecular weight of the hyaluronic acid or the salt thereof is 55-200kDa;

based on the total weight of the electronic cigarette liquid, the hyaluronic acid or the salt thereof is 0.005 to 1.5wt%, and the gamma-aminobutyric acid is 0.005 to 10wt%;

the auxiliary material is at least one of glycerol, propylene glycol and nicotine.

13. The production method according to claim 12,

the hyaluronic acid or the salt thereof accounts for 0.01-0.1wt% of the total weight of the electronic cigarette liquid, and the gamma-aminobutyric acid accounts for 0.01-5 wt%.

14. The method according to claim 12, wherein the molecular weight of the hyaluronic acid or the salt thereof is 55-80kDa.

15. The preparation method according to claim 12, wherein the plant extract accounts for 1 to 30wt% of the total weight of the electronic cigarette liquid.

16. The method of claim 15,

the plant extract accounts for 5-30wt% of the total weight of the electronic cigarette liquid.

17. The method of claim 15,

the plant extract is selected from one or more of sweet orange oil, orange extract, green tea extract, coffee extract, and lemon oil.

18. The method of claim 12,

based on the total weight of the electronic cigarette liquid, the glycerol accounts for 20-80wt%, the propylene glycol accounts for 5-60wt%, and the nicotine accounts for 0-5wt%.

19. The production method according to claim 12,

the nicotine accounts for 1-5wt% of the total weight of the electronic cigarette liquid.