CN105362091B - A kind of composition containing γ-aminobutyric acid and hyaluronic acid and its application in cosmetics - Google Patents
A kind of composition containing γ-aminobutyric acid and hyaluronic acid and its application in cosmetics Download PDFInfo
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- CN105362091B CN105362091B CN201510943689.6A CN201510943689A CN105362091B CN 105362091 B CN105362091 B CN 105362091B CN 201510943689 A CN201510943689 A CN 201510943689A CN 105362091 B CN105362091 B CN 105362091B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596
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Abstract
The invention discloses a kind of composition containing gamma aminobutyric acid and hyaluronic acid and its application in cosmetics, the composition active ingredient includes gamma aminobutyric acid and hyaluronic acid or its salt.The adverse reaction that the present invention can significantly improve, reduce gamma aminobutyric acid to skin, overcome the stimulation that gamma aminobutyric acid is used alone to skin, improve content of the gamma aminobutyric acid in cosmetics, the quick anti-wrinkle of energy, long-acting moisturizing, make skin rejuvenation, suitable for preparing facial mask, face cream, lotion, Essence, essence lotion, eye cream, import the various cosmetics applicatory such as liquid.
Description
Technical field
The present invention relates to a kind of composition containing γ-aminobutyric acid and hyaluronic acid, further relate to the composition anti-wrinkle,
Application in moisturizing, moisturizing class cosmetics, belongs to technical field of skin care.
Background technology
Crease-resistant, anti-wrinkle, anti-aging are the topics that people seeking beauty is eternally immutable through the ages.With advancing age and outside
Portion's environment influences, and skin dimness, wrinkle are successively in forehead, upper palpebra inferior, paropia, ear proparea, cheek, neck, lower chin, mouth week etc.
Position occurs.The factors such as age, skin water content, mental element, sleep, solarization, nutrition condition can cause wrinkle to generate.From
So far, people attempt the generation that tonic, Chinese herbal medicine, peptides skin care item etc. delay wrinkle to Gu, and these methods tell on slowly
Even without effect.
γ-aminobutyric acid (GABA), also known as amino acid injection-800,4-Aminobutanoicacid, nipecotic acid, molecular formula C4H9NO2, molecular weight
103.1.γ-aminobutyric acid is the inhibitory neurotransmitter of mammalian central nervous system, is distributed widely in protokaryon and eukaryon
In biology, research has shown that it has and alleviates anxiety, blood pressure lowering, improves sleep, anti-wrinkle and whitening effect.In anti-wrinkle,
γ-aminobutyric acid can loosen tight myoneural tissue, and fast skin penetration desalinates microgroove, and enhancing muscle itself loosens
Function plays quick anti-wrinkle effect.
Using this property of γ-aminobutyric acid, foreign countries have developed a series of products such as facial mask, face cream, eye cream etc. and are used in
Anti-wrinkle field, to people seeking beauty to wish, but it is unavoidable be, when the concentration of γ-aminobutyric acid reach anti-wrinkle concentration or
It is expected that when reaching better anti-wrinkle concentration, sharp, the numb, malaise symptoms such as itch, is scorching hot are just will produce with skin contact, and this
Side effect has positive correlation with its concentration, currently, content of the γ-aminobutyric acid in cosmetics recommends up to 5.0%, this
Extensive use of the γ-aminobutyric acid in anti-wrinkle field is limited to a certain extent.
Hyaluronic acid (HA) is by the straight chain high score that N-acetylglucosamine and glucuronic acid are that dissacharide units form
Sub- polysaccharide has strong moisture retention and viscoelasticity, is generally acknowledged in the world natural moisturizing factor.It, can after it acts on skin surface
Increase skin lubrication sense, keep that skin is smooth, moist, high resilience, and with water conservation, lubrication, film forming, repair, sun-proof etc. more
Kind function.There is the report for slowing down effect to occur to γ-aminobutyric acid side effect currently, yet there are no hyaluronic acid.
Invention content
The present invention provides a kind of composition containing γ-aminobutyric acid and hyaluronic acid, the composition pass through gamma-amino fourth
The compounding of acid and hyaluronic acid slows down side effect when γ-aminobutyric acid uses, and compounds the composition of gained while having more
Excellent anti-wrinkle effect.
The application in cosmetics that the present invention also provides above-mentioned compositions and the cosmetics containing above-mentioned composition.
Just as mentioned in the background art, when using γ-aminobutyric acid in cosmetics, concentration can make skin when increasing
The performance for the effects that generating sharp, the numb, malaise symptoms such as itch, is scorching hot, limiting its anti-wrinkle, whitening.Inventor asks for this
Topic, constantly finds solution, so that γ-aminobutyric acid can be used preferably in cosmetics.It is found when research, it will
γ-aminobutyric acid is used in compounding with hyaluronic acid or its salt, and the presence of hyaluronic acid or its salt can make γ-aminobutyric acid to skin
The side effect of generation effectively slows down, this discovery allows content of the γ-aminobutyric acid in cosmetics to carry on the original basis
Height, to reach better effect.
In order to slow down γ-aminobutyric acid side effect, the present invention provides following compositions：
A kind of composition, active ingredient include γ-aminobutyric acid and hyaluronic acid or its salt.In the composition, by saturating
The addition of bright matter acid slows down the side effect of γ-aminobutyric acid, and cooperates with the anti-wrinkle effect for increasing γ-aminobutyric acid.
Contain γ-aminobutyric acid, hyaluronic acid or its salt in above-mentioned composition, because γ-aminobutyric acid has anti-wrinkle, U.S.
The effects that white, hyaluronic acid or its salt have the effects that moisturizing, reparation, sun-proof, therefore the present composition has gamma-amino fourth
Moisturizing that acid, hyaluronic acid or its salt itself have, crease-resistant, whitening, reparation and other effects, and γ-aminobutyric acid can be reduced
Side effect to skin.The active ingredient of the composition both can be only γ-aminobutyric acid and hyaluronic acid or its salt, can also
Some other active ingredients are added on the basis of γ-aminobutyric acid and hyaluronic acid or its salt, such as some can be added and shows
Having has same γ-aminobutyric acid, hyaluronic acid or other identical active ingredients of its salt action disclosed in technology, anti-to increase
Wrinkle, moisturizing, whitening, reparation and other effects, for example, small-molecule peptide, collagen, glycine betaine, saualane, trehalose, butanediol,
Compound amino acid, glycerine, creatine, tranexamic acid, D-pantothenyl aleohol, niacinamide, ferulic acid, lipoic acid, plant extracts, chitosan,
Chondroitin sulfate, heparin, ceramide, lecithin, vaseline, stearic acid, arachidic acid, cetyl ester etc.；It can also be added
Disclosed in some prior arts with other effects except γ-aminobutyric acid and hyaluronic acid or its salt action it is effective at
Point, diversity the effect of to increase composition, such as can be added nti-freckle active ingredient (can specifically select tranexamic acid,
Ursin, kojic acid, ellagic acid, Lu Sisu, vitamin C and its derivative, placental hormone etc.), anti-acne active ingredient (can specifically select
Select Tretinoin, retinol, dimension A aldehyde, Glycolic acid, salicylic acid, malic acid, citric acid etc.), antiallergy active ingredient (can specifically select
Select D-pantothenyl aleohol, bisabolol, enoxolone, allantoin, purslane extract, dipotassium glycyrrhizinate, vitamin E, plant extracts
Deng) etc.；Can also be added disclosed in the prior art can be used in compounding with γ-aminobutyric acid or hyaluronic acid or its salt with
Reach other skin care effective constituents of synergistic effect.
In addition, in order to which composition is formed in different parts, according to different gimmicks form all easy to use when, such as make
When at facial mask, face cream, lotion, Essence, toner, eye cream or importing the different forms such as liquid, above-mentioned composition in addition to effectively at
Exceptionally, can also include that various forms of auxiliary materials are made in active ingredient.
In above-mentioned composition, in order to slow down the side effect of γ-aminobutyric acid when in use, hyaluronic acid used or its salt
It can be the hyaluronic acid or its salt of unimodal molecular weight, or the mixture of the hyaluronic acid of different molecular weight or its salt.
Either single transparent matter acid or mixed transparent matter acid, molecular weight can disclosed can be used for from the prior art
Hyaluronic acid in cosmetic arbitrarily selects in the molecular weight of its salt, such as molecular weight can be selected from≤300 ten thousand range,
It can select, can be selected from≤100 ten thousand range from≤200 ten thousand range, can be selected from≤80 ten thousand range,
It can select, can be selected from≤10 ten thousand range from≤50 ten thousand range, can be selected from≤1 ten thousand range, when
Effect is more preferable when molecular weight selection≤100 ten thousand.
Further, the skin care effect of the hyaluronic acid of different molecular weight or its salt is different, therefore works as and use different molecular
When the mixture of the hyaluronic acid of amount or its salt to compound with γ-aminobutyric acid, the side effect of γ-aminobutyric acid when in use
Slow down effect to act on obviously than unimodal molecular weight hyaluronic acid or slowing down for its salt.Preferably, using polymer hyaluronic acid or
Its salt is compounded with the mixture of low-molecular-weight hyaluronic acid or its salt and γ-aminobutyric acid.Remember relatively high transparent of molecular weight
Matter acid or its salt are high molecular weight hyaluronic acid or its salt, remember that molecular weight relatively low hyaluronic acid or its salt are that low molecule is saturating
Bright matter acid or its salt are low less than 10,000 more than or equal to 10,000 high molecular weight hyaluronic acid or its salt and molecular weight using molecular weight
When the mixture of molecular weight hyaluronic acid or its salt and γ-aminobutyric acid compound, side effect slows down γ-aminobutyric acid when in use
Effect becomes apparent.It is furthermore preferred that being less than 1 using the high molecular weight hyaluronic acid of molecular weight 1-300 ten thousand or its salt and molecular weight
Effect is more preferable when the mixture of ten thousand low molecular weight hyaluronic acid or its salt is compounded with γ-aminobutyric acid, more it is furthermore preferred that using dividing
The low molecular weight hyaluronic acid of high molecular weight hyaluronic acid or its salt and molecular weight less than 10,000 of son amount 30-80 ten thousand or mixing for its salt
It is more preferable to close effect when object is compounded with γ-aminobutyric acid.
The present composition contains γ-aminobutyric acid and hyaluronic acid or its salt the experiment has found that γ-aminobutyric acid with thoroughly
The compounding of bright matter acid or its salt can not only slow down the side effect of γ-aminobutyric acid, also have significantly more anti-wrinkle effect.It is transparent
Matter acid or its salt penetrate into skin interior energy and are inflated skin rapidly, fill wrinkle, and γ-aminobutyric acid being capable of calm nerves conduction loose list
Feelings flesh, while collagen being promoted in skin to generate to mitigate wrinkle, when by two kinds of cytoplasm component transparent matter acid and its
Salt is combined with aminobutyric acid, can not only significantly reduce irritation of the γ-aminobutyric acid to skin, but also can reach and discharge layer by layer,
Multiple crease-resistant effect plays long-acting and short-acting dual synergistic effect.
In above-mentioned composition of the present invention, with the increase of hyaluronic acid addition, composition is when in use to the thorn of skin
Swashing reduces, and the wrinkle improvement effect of composition is also different.Show in a preferred embodiment of the invention, when γ-aminobutyric acid with
The mass ratio of hyaluronic acid or its salt is 10:1-1:When 10, while the wrinkle improvement effect of composition is good to the stimulation of skin also compared with
It is low, when the mass ratio of γ-aminobutyric acid and hyaluronic acid or its salt is 10：1-1:When 5, the wrinkle improvement effect of composition and to skin
Effect of stimulation it is more preferable.
In above-mentioned composition of the present invention, the selection of the molecular weight of high and low molecular weight hyaluronic acid or its salt is for composition
Wrinkle improvement effect also have an impact.In a preferred embodiment of the invention, the molecular weight of high molecular weight hyaluronic acid or its salt is 1-
Wrinkle improvement effect is good when 1000000, and effect is best when molecular weight is 30-80 ten thousand.The molecular weight of low-molecular-weight hyaluronic acid or its salt is small
Wrinkle improvement effect is preferable when 10,000, such as 3000-10000 (not including 10000).
In above-mentioned composition of the present invention, the smoothing wrinkle of the mass ratio of high and low molecular weight hyaluronic acid or its salt for composition
Effect and composition have an impact the stimulation degree of skin, show in a preferred embodiment of the invention, work as high molecular weight
Hyaluronic acid or its salt and the mass ratio of low-molecular-weight hyaluronic acid or its salt are 10:1-1:When 10, composition wrinkle improvement effect is good
While it is relatively low to the stimulation of skin, when the matter of high molecular weight hyaluronic acid or its salt and low-molecular-weight hyaluronic acid or its salt
Amount is than being 5:1-1:The wrinkle improvement effect of composition is more preferable when 5, to the irritation smaller of skin.
In above-mentioned composition of the present invention, the salt of the hyaluronic acid can be times of disclosed hyaluronic acid in the prior art
One or more of meaning salt, such as sodium salt, sylvite, zinc salt and calcium salt, it is relatively common for hyaluroni.Each hyalomitome
The effect of hydrochlorate is similar.
Above-mentioned composition of the present invention, preparation method are：By γ-aminobutyric acid solid and low molecular weight hyaluronic acid or its salt
Solid mixes, and polymer hyaluronic acid or its salt solid are added after mixing well, and continues stirring until three kinds of materials are fully mixed
It closes uniformly, then crosses 40 mesh sieve, obtain composition.
In above-mentioned preparation method, γ-aminobutyric acid solid and low molecular weight hyaluronic acid or its salt solid are stirred at room temperature
Mixing.
In above-mentioned preparation method, because polymer hyaluronic acid or its salt are easy to moisture absorption, in order to avoid being mixed in mixed process
Object water suction is closed, is stirred under 45-75 DEG C and condition of negative pressure after polymer hyaluronic acid or its salt is added.
Above-mentioned composition of the present invention is few to skin irritatin, and anti-wrinkle effect is good, while also having moisturizing, reparation, whitening equivalent
Fruit, therefore can be used in all types of cosmetics.Therefore, application of the above-mentioned composition of the present invention in cosmetics is also the present invention
Protection domain.
In above application, the cosmetics are preferably at least one of crease-resistant, anti-wrinkle, whitening and moisturizing effect
Cosmetics preferably have crease-resistant, anti-wrinkle effect cosmetics.
In above application, the cosmetics can be facial mask, face cream, lotion, Essence, toner, eye cream or import liquid.
In above application, the present composition preferably as cosmetics active ingredient, more preferably as cosmetics moderate resistance
The active ingredient of at least one of wrinkle, anti-wrinkle, whitening and moisturizing effect.
In above application, the present composition can be the single active ingredient of cosmetics, can also be with other effectively
Ingredient is used in mixed way, and cosmetics is better when mixed with other active ingredients.
Further, including the cosmetics of above-mentioned composition of the present invention are also within the scope of the present invention.The cosmetics
Active ingredient or raw material include the above-mentioned composition stated of the present invention.
Further, which is preferably the makeup at least one of crease-resistant, anti-wrinkle, whitening and moisturizing effect
Product preferably have crease-resistant, anti-wrinkle effect cosmetics.
Further, which can be using the present composition as single active ingredient or raw material, can also be with this
Inventive composition and the mixture of other active ingredients are active ingredient or raw material, cosmetics when mixed with other active ingredients
It is better.
The present composition has at least one of crease-resistant, anti-wrinkle, whitening and moisturizing effect in cosmetics.
Further, in the cosmetics, the γ-aminobutyric acid in composition accounts for all components total weight in cosmetics
0.1%~15%, it is preferred that γ-aminobutyric acid accounts for 0.5%~10% of all components total weight in cosmetics, it is furthermore preferred that
γ-aminobutyric acid accounts for 5.1%~10% of all components total weight in cosmetics.Currently, γ-aminobutyric acid is in cosmetics
Content most multipotency reaches 5%, and best recommended amounts are 3%, and the present composition can make γ-aminobutyric acid in cosmetics
Content reaches 5% or more and non-evident effect, significant effect.
Further, the cosmetics can be facial mask, face cream, lotion, Essence, toner, eye cream or import liquid.
Beneficial effects of the present invention：
1, it is conducted comprising hyaluronic acid and γ-aminobutyric acid, Gabanergic calm nerves in the present composition,
Relaxation mimetic muscle, wrinkle reduction, hyaluronic acid can penetrate into skin, rapid to fill, to play the role of reducing wrinkle, through short-term
With long-term anti-wrinkle experimental verification, the quick anti-wrinkle of this composition energy, long-acting moisturizing makes skin rejuvenation, overcomes the prior art and dispel
The slow defect of wrinkle；
2, the present composition can significantly improve through clinic trial experimental verification, reduce γ-aminobutyric acid to the red of skin
The generally acknowledged adverse reactions such as spot, shouting pain, numb gargalesthesia, overcome the stimulation that γ-aminobutyric acid is used alone to skin, improve γ-
Content of the aminobutyric acid in cosmetics, and the two synergistic effect can increase composition anti-wrinkle effect, be suitable for preparation face
Film, lotion, Essence, essence lotion, eye cream, imports the various cosmetics applicatory such as liquid at face cream.
Specific implementation mode
In the following, by specific embodiment, the present invention will be further elaborated and explanation, following embodiments are merely illustrative
Property, its content is not defined.
In following embodiments, it is raw materials used it is equal can be bought from market, wherein less than 10,000 hyaluronic acid or its salt, big
It is all from Bloomage Freda Biopharm Co., Ltd. in 10,000 hyaluronic acid or its salt and γ-aminobutyric acid.
Embodiment 1
Composite formula is：γ-aminobutyric acid 10g, high molecular weight sodium hyaluronate (molecular weight is 1-10 ten thousand) 20g are low
Molecular weight hyaluronic acid sodium (being less than 10,000) 80g.
Preparation method is：γ-aminobutyric acid and low-numerator sodium hyaluronate are stirred in agitated kettle under room temperature, fully
Put into polymer hyaluronic acid sodium again after mixing, it is 45-75 DEG C then to maintain stirring pot temperature, continues to stir under negative pressure
It mixes, until three kinds of materials mix well, 40 mesh sieve is crossed after mixing to get composition.The composition is powdered.
The composition of above-mentioned preparation can be added to as the component of cosmetics in cosmetics, be used to prepare facial mask, face cream,
Lotion, essence lotion, eye cream, imports the various cosmetics applicatory such as liquid at Essence.
The preparation method and purposes of composition in the following example 2-12 are the same as embodiment 1.
Embodiment 2
Composite formula is：γ-aminobutyric acid 45g, molecular weight are the calcium hyauronate 5g of 80-100 ten thousand, less than 10,000
Calcium hyauronate 50g.The preparation method is the same as that of Example 1.
Embodiment 3
Composite formula is：γ-aminobutyric acid 100g, molecular weight are the potassium hyaluronate 5g of 20-50 ten thousand, less than 10,000
Potassium hyaluronate 5g.The preparation method is the same as that of Example 1.
Embodiment 4
Composite formula is：γ-aminobutyric acid 10g, molecular weight are the Sodium Hyaluronate 20g of 50-60 ten thousand, less than 10,000
Sodium Hyaluronate 30g.The preparation method is the same as that of Example 1.
Embodiment 5
Composite formula is：γ-aminobutyric acid 275g, molecular weight are the hyaluronic acid 50g of 250-300 ten thousand, less than 10,000
Hyaluronic acid 5g.The preparation method is the same as that of Example 1.
Embodiment 6
Composite formula is：γ-aminobutyric acid 30g, molecular weight are the Sodium Hyaluronate 60g of 20-30 ten thousand, less than 10,000
Sodium Hyaluronate 20g.The preparation method is the same as that of Example 1.
Embodiment 7
Composite formula is：γ-aminobutyric acid 40g, molecular weight are the hyaluronic acid 50g of 180-200 ten thousand, less than 10,000
Hyaluronic acid 10g.The preparation method is the same as that of Example 1.
Embodiment 8
Composite formula is：γ-aminobutyric acid 420g, molecular weight are the Sodium Hyaluronate 50g of 30-80 ten thousand, less than 10,000
Sodium Hyaluronate 10g.The preparation method is the same as that of Example 1.
Embodiment 9
Composite formula is：γ-aminobutyric acid 10g, molecular weight are the hyaluronic acid 10g of 100-120 ten thousand, less than 10,000
Hyaluronic acid 50g.The preparation method is the same as that of Example 1.
Embodiment 10
Composite formula is：γ-aminobutyric acid 40g, molecular weight is the hyaluronic acid 30g of 30-80 ten thousand, saturating less than 10,000
Bright matter acid 20g.The preparation method is the same as that of Example 1.
Embodiment 11
Composite formula is：γ-aminobutyric acid 20g, molecular weight is the hyaluronic acid 20g of 50-60 ten thousand, saturating less than 10,000
Bright matter acid 80g.The preparation method is the same as that of Example 1.
Embodiment 12
Composite formula is：γ-aminobutyric acid 50g, molecular weight is the hyaluronic acid 25g of 30-50 ten thousand, saturating less than 10,000
Bright matter acid 25g.The preparation method is the same as that of Example 1.
Embodiment 13
According to the formula in the following table 1, multigroup composition is prepared, hyaluronic acid used is hyaluroni, for convenience
Description, hyaluronic acid A and hyaluronic acid B are defined as by the Sodium Hyaluronate of different molecular weight.
The preparation method of the composition is：By γ-aminobutyric acid and low-numerator sodium hyaluronate in agitated kettle under room temperature
Stirring puts into polymer hyaluronic acid sodium again after being sufficiently mixed uniformly, and it is 60-75 DEG C then to maintain stirring pot temperature, in negative pressure
Under continue to stir, until three kinds of materials mix well, 40 mesh sieve is crossed after mixing to get composition.
1 composition of table matches table
Application examples
In order to verify the effect of the present composition, following experiment is carried out：
1, used sample：
Laboratory sample：Composition 10g in Example 13, appropriate Preservative Technology for Personal Care add purified water to 100ml,
It stirs evenly, obtains laboratory sample 1-1~1-18.
Control sample 1：The most normal recommended amounts 3.0g of γ-aminobutyric acid, appropriate Preservative Technology for Personal Care is taken to add purified water extremely
100ml, stir evenly to get.
Control sample 2：γ-aminobutyric acid 9.0g, appropriate Preservative Technology for Personal Care is taken to add purified water to 100ml, stirring is equal
It is even to get.
Control sample 3：It takes molecular weight to be more than 750,000 Sodium Hyaluronate 0.5g, is less than 10,000 Sodium Hyaluronate 0.5g, change
Cosmetic Preservative qs add purified water to 100ml, stir evenly to get.
Control sample 4：Appropriate preservative adds purified water to 100ml, stir evenly to get.
2, experimental method
2.1 anti-wrinkle evaluation experimental methods
Laboratory sample 1-1~1-18 is carried out with control sample 1, control sample 2, control sample 3 and control sample 4 respectively
Check experiment, by the way of the control of half face, one side of something smears laboratory sample, and one side of something smears control sample.Each laboratory sample is recruited
Raise 20 volunteers, and age 30-50 Sui, men and women is unlimited.Short-term anti-wrinkle effect be measure smear before, smear after 30min, 1h, 3h
With the crow's foot depth of 6h, wrinkle mean depth relative value is calculated.Long-term anti-wrinkle effect expedition 4 weeks, before measurement is smeared respectively,
1 week, 2 weeks, 3 weeks and 4 weeks wrinkle depth after smearing calculates wrinkle mean depth relative value.
Wherein：Wrinkle mean depth (Sa) relative value=× 100%
2.2 irritation evaluation experimental methods
While anti-wrinkle evaluation experimental, observation volunteer uses the irritation of laboratory sample and control sample, scoring former
Then with reference to skin irritation test code of points in cosmetics health specification, while experiencing scoring plus the supervisor of volunteer, comments
The irritation of valence sample.The skin wound repair scoring of this experiment is shown in Table 2.
Stimulate scoring=integral summation/tested volunteer quantity
2 skin wound repair of table scores
2.3 laboratory apparatus：Human skin rapid three dimensional imaging system (PRIMOS, Germany).
2.4 anti-wrinkle and slow down stimulation test result
2.4.1 short-term anti-wrinkle effect, is shown in Table 3.
3 short-term anti-wrinkle effect of table compares
From the above experiments, it was found that the anti-wrinkle effect of 1-1~1-17 compositions is significantly better than control sample 1-4.Into
One step, the content of the aminobutyric acid of 1-8,1-9,1-17 is less than control sample 1, but their anti-wrinkle effects are better than control sample
Product 1；The content of the aminobutyric acid of 1-1~1-7,1-10~1-16 is below control sample 2, but their anti-wrinkle effect is good
In control sample 2.By the data comparison of 1-1~1-2 and 1-3~1-5,1-11~1-16 can be seen that unimodal molecular weight and
The introducing of the hyaluronic acid of combined molecular weight or its salt can increase the anti-wrinkle effect of γ-aminobutyric acid, but the hyalomitome compounded
Acid or its salt cooperative synergism effect become apparent from.Gamma-propalanine content, transparent is can be seen that from the comparison of 1-18 and 1-1~1-17
The selection of matter acid dosage and hyaluronan molecule amount has larger impact for anti-wrinkle effect.
2.4.2, long-term anti-wrinkle effect
4 long-term anti-wrinkle effect of table compares
From the above experiments, it was found that the anti-wrinkle effect of 1-1~1-17 compositions is significantly better than control sample 1-4.Into
One step, the content of the aminobutyric acid of 1-8,1-9,1-17 is less than control sample 1, but their anti-wrinkle effects are better than control sample
Product 1；The content of the aminobutyric acid of 1-1~1-7,1-10~1-16 is below control sample 2, but their anti-wrinkle effect is good
In control sample 2.By the data comparison of 1-1~1-2 and 1-3~1-5,1-11~1-16 can be seen that unimodal molecular weight and
The introducing of the hyaluronic acid of combined molecular weight or its salt can increase the anti-wrinkle effect of γ-aminobutyric acid, but the hyalomitome compounded
Acid or its salt cooperative synergism effect become apparent from.Gamma-propalanine content, transparent is can be seen that from the comparison of 1-18 and 1-1~1-17
The selection of matter acid dosage and hyaluronan molecule amount has larger impact for anti-wrinkle effect.
2.4.3 skin irritation evaluation result
5 skin irritation result of table
From the above experiments, it was found that all anti-wrinkle compositions are significantly better than the side effect of skin and do not add hyalomitome
The sample of acid and blank control.Further, laboratory sample 1-1 and 1-2 is put in different times has slight numb gargalesthesia to occur,
Laboratory sample 1-3~1-18 does not have during experiment or extremely slight side effect, such as gargalesthesia occurs, when noticeable,
, there are more fiber crops, itch, shouting pain, and in control sample 2 in 2 samples of control 1 and control for not adding hyaluronic acid or its salt
Occur the volunteer of a small amount of erythema and oedema.This shows hyaluronic acid or its salt is exact is slowing down γ-aminobutyric acid to skin
The side reaction of skin.There is erythema and tingling sensation volunteer in week 3 and Week 4 in control sample 4 (preservative), shows to make for a long time
Also there is ill-effect to skin with preservative, and hyaluronic acid and the anti-wrinkle composition of the present invention can also reduce the bad of preservative
Reaction.
Although above, detailed explanation has been done to the present invention with generality explanation and embodiment, the present invention's
On the basis of, can be modified or improve, this it will be apparent to those skilled in the art that.Therefore, without departing from this hair
Modifications or improvements on the basis of bright spirit, belong to the scope of protection of present invention.
Claims (12)
1. a kind of composition, it is characterized in that：Active ingredient includes γ-aminobutyric acid and hyaluronic acid or its salt, the gamma-amino
Butyric acid is 10 with the mass ratio of hyaluronic acid or its salt:1-1:10；The hyaluronic acid or its salt are high molecular weight hyaluronic acid
Or the mixture of its salt and low-molecular-weight hyaluronic acid or its salt, the molecular weight of the high molecular weight hyaluronic acid or its salt is 1-
3000000, the molecular weight of the low-molecular-weight hyaluronic acid or its salt is less than 10,000；High molecular weight hyaluronic acid or its salt and low point
The mass ratio of son amount hyaluronic acid or its salt is 10:1-1:10.
2. composition according to claim 1, it is characterized in that：Active ingredient be only γ-aminobutyric acid and hyaluronic acid or
Its salt.
3. composition according to claim 1, it is characterized in that：The molecular weight of the high molecular weight hyaluronic acid or its salt is
30-80 ten thousand.
4. composition according to claim 1, it is characterized in that：High molecular weight hyaluronic acid or its salt and low molecular weight are transparent
The mass ratio of matter acid or its salt is 5:1-1:5.
5. according to the composition described in any one of claim 1-4, it is characterized in that：γ-aminobutyric acid and hyaluronic acid or its
The mass ratio of salt is 10：1-1:5.
6. according to the composition described in any one of claim 1-4, it is characterized in that：The salt of the hyaluronic acid is sodium salt, potassium
One or more of salt, zinc salt and calcium salt.
7. application of the composition described in any one of claim 1-6 in cosmetics.
8. application according to claim 7, it is characterized in that：The cosmetics are facial mask, face cream, lotion, Essence, makeup
Water, eye cream import liquid.
9. a kind of cosmetics, it is characterized in that：Active ingredient or raw material include the composition described in any one of claim 1-6.
10. cosmetics according to claim 9, it is characterized in that：γ-aminobutyric acid in composition, which accounts in cosmetics, to be owned
The 0.1%~15% of component gross mass.
11. cosmetics according to claim 9, it is characterized in that：γ-aminobutyric acid in composition, which accounts in cosmetics, to be owned
The 0.5%~10% of component gross mass.
12. according to the cosmetics described in claim 9,10 or 11, it is characterized in that：The cosmetics be facial mask, face cream, lotion,
Essence, toner, eye cream import liquid.
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| CN106038345A (en) * | 2016-06-06 | 2016-10-26 | 山东水晶生物科技股份有限公司 | Mask containing gamma-aminobutyric acid |
| CN107475151B (en) * | 2017-08-30 | 2019-10-18 | 华熙生物科技股份有限公司 | The lactic acid bacteria of one plant of highly producing gamma-aminobutyric acid and its application |
| CN109316377A (en) * | 2018-10-11 | 2019-02-12 | 西安医学院 | A kind of compound Essence and preparation method containing fusion protein |
| CN109363966A (en) * | 2018-11-02 | 2019-02-22 | 华熙福瑞达生物医药有限公司 | A kind of inclusion compound containing γ-aminobutyric acid, alpha-arbutin and hyaluronic acid |
| CN111388349A (en) * | 2020-04-26 | 2020-07-10 | 华熙生物科技股份有限公司 | Facial mask containing moisturizing and whitening essence and preparation method thereof |
| CN112089665B (en) * | 2020-10-21 | 2021-04-16 | 广州惜颜生物科技有限公司 | Essence lotion with effects of resisting aging and removing deep wrinkles and preparation method thereof |
| CN112402327A (en) * | 2020-12-24 | 2021-02-26 | 北京旋光普利生物医药科技开发有限公司 | Preparation of hydrolat amino butyric acid toner (toning lotion) |
| CN112675060B (en) * | 2021-01-06 | 2022-08-26 | 山东华熙海御生物医药有限公司 | Composition and skin care product for resisting skin aging and preparation method thereof |
| CN113143795A (en) * | 2021-05-18 | 2021-07-23 | 华熙生物科技股份有限公司 | Composition containing gamma-aminobutyric acid and application thereof |
| CN113679046B (en) * | 2021-08-20 | 2024-03-08 | 华熙生物科技股份有限公司 | Composition for promoting interaction of hyaluronic acid and collagen and application thereof |
| CN114304714B (en) * | 2021-12-28 | 2023-03-21 | 华熙生物科技股份有限公司 | Electronic cigarette liquid and preparation method thereof |
| CN114317628B (en) * | 2021-12-28 | 2024-03-08 | 华熙生物科技股份有限公司 | Gamma-aminobutyric acid product with low irritation, preparation method thereof and application of gamma-aminobutyric acid product with low irritation |
| CN115386095B (en) * | 2022-07-12 | 2024-03-22 | 华熙生物科技股份有限公司 | Penetration enhancer, skin care composition and cosmetic |
| CN115010949B (en) * | 2022-07-12 | 2024-02-13 | 华熙生物科技股份有限公司 | Penetration enhancer, skin care composition and cosmetic |
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