CN105362091A - Composition containing gamma-aminobutyric acid and hyaluronic acid and application of same to cosmetics - Google Patents
Composition containing gamma-aminobutyric acid and hyaluronic acid and application of same to cosmetics Download PDFInfo
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- CN105362091A CN105362091A CN201510943689.6A CN201510943689A CN105362091A CN 105362091 A CN105362091 A CN 105362091A CN 201510943689 A CN201510943689 A CN 201510943689A CN 105362091 A CN105362091 A CN 105362091A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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Abstract
The invention discloses a composition containing gamma-aminobutyric acid and hyaluronic acid and application of the same to cosmetics. Effective constituents of the composition comprise gamma-aminobutyric acid and hyaluronic acid or hyaluronate. By means of the composition, adverse reactions to skin caused by the gamma-aminobutyric acid can be remarkably improved and lowered, skin irritation caused when the gamma-aminobutyric acid is used solely is overcome, the content of the gamma-aminobutyric acid in cosmetics is raised, wrinkles can be removed rapidly, moisture can be replenished in a long-acting mode, the skin is rejuvenated, and the composition is suitable for being used for preparing various applicable cosmetics such as a facial mask, face cream, emulsion, essence emulsion, an essence lotion, eye cream and a toner.
Description
Technical field
The present invention relates to a kind of containing γ-aminobutyric acid and hyaluronic compositions, also relate to the application of said composition in wrinkle removal, moisturizing, moisturizing class cosmetics, belong to technical field of skin care.
Background technology
Crease-resistant, wrinkle removal, slow down aging are the eternally immutable topics of personage of liking to be beautiful through the ages.With advancing age and external environment influence, dim, the wrinkle of skin occurs in positions such as forehead, upper palpebra inferior, paropia, ear proparea, cheek, cervical region, lower chin, mouth weeks successively.The factors such as age, skin beauty water content, Nervous and Mental Factors, sleep, Exposure to Sunlight, nutriture all can cause wrinkle to produce.From ancient times to the present, people attempt the generation that tonic, Chinese herbal medicine, peptide class skin care item etc. delay wrinkle, and these methods tell on and slowly even do not have effect.
γ-aminobutyric acid (GABA), also known as aminobutyric acid, 4-Aminobutanoicacid, nipecotic acid, molecular formula C
4h
9nO
2, molecular weight 103.1.γ-aminobutyric acid is the inhibitory neurotransmitter of mammalian central nervous system, is distributed widely in protokaryon and eukaryote, has studied and has proved that it has the effect alleviating anxiety, blood pressure lowering, improving water flood, wrinkle removal and whitening.When wrinkle removal, γ-aminobutyric acid can loosen tight myoneural tissue, fast skin penetration, and desalination microgroove, what strengthen muscle itself loosens function, plays quick wrinkle removal effect.
Utilize this character of γ-aminobutyric acid, have developed a series of product abroad as facial film, facial cream, eye creams etc. are used in wrinkle removal field, to the personage that likes to be beautiful with hope, but be unavoidablely, when the concentration of γ-aminobutyric acid reaches wrinkle removal concentration or expectation reaches better wrinkle removal concentration, will produce sharp with contact skin, fiber crops, itch, scorching hot malaise symptoms such as grade, and this side effect and its concentration have positive correlation, at present, the content of γ-aminobutyric acid in cosmetics is recommended to be up to 5.0%, this limits the extensive use of γ-aminobutyric acid in wrinkle removal field to a certain extent.
Hyaluronic acid (HA) is the straight chain polymer polysaccharide that dissacharide units forms by 2-Acetamido-2-deoxy-D-glucose and glucuronic acid, has strong moisture retention and viscoelasticity, is the nature moisturizing factor of generally acknowledging in the world.After it acts on skin surface, skin lubrication sense can be increased, keep smooth, moist, the high resilience of skin, and there is water conservation, lubrication, film forming, reparation, the several functions such as sun-proof.At present, yet there are no hyaluronic acid has the report slowing down effect to occur to γ-aminobutyric acid side effect.
Summary of the invention
The invention provides a kind of containing γ-aminobutyric acid and hyaluronic compositions, said composition is by γ-aminobutyric acid and the hyaluronic composite side effect that slow down when γ-aminobutyric acid uses, and the compositions of composite gained has more excellent wrinkle removal effect simultaneously.
Present invention also offers the application of above-mentioned composition in cosmetics and the cosmetics containing above-mentioned composition.
Just as mentioned in the background art, when using γ-aminobutyric acid in cosmetics, can make when its concentration raises skin produce sharp, numb, itch, the malaise symptoms such as scorching hot, limit the performance that its wrinkle removal, whitening etc. acts on.Inventor, for this problem, constantly finds solution, can better use in cosmetics to make γ-aminobutyric acid.Find during research, by γ-aminobutyric acid and hyaluronic acid or the composite use of its salt, the existence of hyaluronic acid or its salt can make γ-aminobutyric acid effectively slow down the side effect that skin produces, this discovery makes the content of γ-aminobutyric acid in cosmetics improve on the original basis, to reach better effect.
In order to slow down γ-aminobutyric acid side effect, the invention provides following compositions:
A kind of compositions, effective ingredient comprises γ-aminobutyric acid and hyaluronic acid or its salt.In said composition, add by hyaluronic the side effect that slow down γ-aminobutyric acid, and the collaborative wrinkle removal effect increasing γ-aminobutyric acid.
Containing γ-aminobutyric acid, hyaluronic acid or its salt in above-mentioned composition, because γ-aminobutyric acid has the effect such as wrinkle removal, whitening, hyaluronic acid or its salt have moisturizing, reparation, the effect such as sun-proof, therefore the present composition has the effects such as moisturizing that γ-aminobutyric acid, hyaluronic acid or its salt itself has, crease-resistant, whitening, reparation, and can reduce the side effect of γ-aminobutyric acid to skin.The effective ingredient of said composition both can be only γ-aminobutyric acid and hyaluronic acid or its salt, also some other effective ingredient can be added on the basis of γ-aminobutyric acid and hyaluronic acid or its salt, such as can add disclosed in some prior aries and there is same γ-aminobutyric acid, hyaluronic acid or identical other effective ingredient of its salt action, crease-resistant to increase, moisturizing, whitening, the effects such as reparation, such as small-molecule peptide, collagen protein, betanin, squalane, trehalose, butanediol, aminoacids complex, glycerol, creatine, tranexamic acid, D-panthenol, nicotiamide, ferulic acid, thioctic acid, plant extract, chitosan, chondroitin sulfate, heparin, ceramide, lecithin, vaseline, stearic acid, arachidic acid, cetyl ester etc., the effective ingredient of other effects had disclosed in some prior aries outside γ-aminobutyric acid and hyaluronic acid or its salt action can also be added, to increase the multiformity of effect of compositions, such as can add speckle dispelling effective ingredient and (specifically can select tranexamic acid, arbutin, kojic acid, ellagic acid, Lu Sisu, vitamin C and derivant thereof, Placenta extract etc.), anti-acne effective ingredient (specifically can select tretinoin, retinol, dimension A aldehyde, glycolic acid, salicylic acid, malic acid, citric acid etc.), antiallergic effective ingredient (specifically can select D-panthenol, bisabolol, enoxolone, allantoin, Herba portulacae extract, glycyrrhizic acid dipotassium, vitamin E, plant extract etc.) etc., can also add disclosed in prior art can with γ-aminobutyric acid or hyaluronic acid or the composite use of its salt to reach other skin type effective ingredient of potentiation.
In addition, during in order to compositions being formed in different parts, according to the form that different maneuver is all easy to use, such as make facial film, facial cream, emulsion, essence, astringent, eye cream or import liquid etc. multi-form time, above-mentioned composition, except effective ingredient, can also comprise and effective ingredient is made multi-form adjuvant.
In above-mentioned composition, in order to slow down γ-aminobutyric acid side effect in use, hyaluronic acid used or its salt can be hyaluronic acid or its salt of unimodal molecular weight, also can be the hyaluronic acid of different molecular weight or the mixture of its salt.No matter be the acid of single transparent matter or the acid of mixed transparent matter, its molecular weight all can be selected arbitrarily from the molecular weight of the hyaluronic acid that may be used for disclosed in prior art cosmetics or its salt, such as molecular weight can be selected from the scope of≤300 ten thousand, can select from the scope of≤200 ten thousand, can select from the scope of≤100 ten thousand, can select from the scope of≤80 ten thousand, can select from the scope of≤50 ten thousand, can select from the scope of≤10 ten thousand, can select from the scope of≤1 ten thousand, the better effects if when molecular weight selection≤100 ten thousand.
Further, the skin care effect of the hyaluronic acid of different molecular weight or its salt is different, therefore, when the mixture of the hyaluronic acid or its salt that use different molecular weight comes composite with γ-aminobutyric acid, the effect that slows down of γ-aminobutyric acid side effect in use acts on obviously than unimodal molecular weight hyaluronic acid or slowing down of its salt.Preferably, adopt the mixture of polymer hyaluronic acid or its salt and low-molecular-weight hyaluronic acid or its salt and γ-aminobutyric acid composite.The hyaluronic acid that note molecular weight is relatively high or its salt are high molecular weight hyaluronic acid or its salt, remember that the hyaluronic acid that molecular weight is relatively low or its salt are low molecular weight hyaluronic acid or its salt, adopt molecular weight be more than or equal to 10,000 high molecular weight hyaluronic acid or its salt and molecular weight be less than the low molecular weight hyaluronic acid of 10,000 or the mixture of its salt and γ-aminobutyric acid composite time, γ-aminobutyric acid in use side effect to slow down effect more obvious.Preferred, adopt the high molecular weight hyaluronic acid of molecular weight 1-300 ten thousand or its salt and molecular weight be less than the low molecular weight hyaluronic acid of 10,000 or the mixture of its salt and γ-aminobutyric acid composite time better effects if, more preferred, adopt the high molecular weight hyaluronic acid of molecular weight 30-80 ten thousand or its salt and molecular weight be less than the low molecular weight hyaluronic acid of 10,000 or the mixture of its salt and γ-aminobutyric acid composite time better effects if.
The present composition contains γ-aminobutyric acid and hyaluronic acid or its salt, and experiment finds, the composite side effect that can not only slow down γ-aminobutyric acid of γ-aminobutyric acid and hyaluronic acid or its salt, also has more significant wrinkle removal effect.Hyaluronic acid or its salt infiltrate in skin and can fill the skin that rises rapidly, fill wrinkle, γ-aminobutyric acid can conduct lax histrionic muscles by calm nerves, promote that in skin, collagen protein generates thus alleviates wrinkle simultaneously, when the acid of two kinds of intercellular substance component transparent matter and salt thereof and aminobutyric acid are combined, not only significantly can reduce the zest of γ-aminobutyric acid to skin, and release, multiple crease-resistant effect layer by layer can be reached, play long-acting and fugitive dual synergism.
In above-mentioned composition of the present invention, along with the increase of hyaluronic acid addition, compositions reduces the stimulation of skin in use, and the wrinkle improvement effect of compositions is also different.Show in a preferred embodiment of the invention, when the mass ratio of γ-aminobutyric acid and hyaluronic acid or its salt is 10:1-1:10, it is also lower to the stimulation of skin while the wrinkle improvement effect of compositions is good, when the mass ratio of γ-aminobutyric acid and hyaluronic acid or its salt is 10:1-1:5, the wrinkle improvement effect of compositions and better to the effect of stimulation of skin.
In above-mentioned composition of the present invention, the selection of the molecular weight of high and low molecular weight hyaluronic acid or its salt also has impact for the wrinkle improvement effect of compositions.In a preferred embodiment of the invention, when the molecular weight of high molecular weight hyaluronic acid or its salt is 1-100 ten thousand, wrinkle improvement effect is good, and when molecular weight is 30-80 ten thousand, effect is best.When the molecular weight of low-molecular-weight hyaluronic acid or its salt is less than 10,000, wrinkle improvement effect is better, such as 3000-10000 (not comprising 10000).
In above-mentioned composition of the present invention, high, the mass ratio of low-molecular-weight hyaluronic acid or its salt all has impact for the wrinkle improvement effect of compositions and the stimulation degree of compositions on skin, show in a preferred embodiment of the invention, when the mass ratio of high molecular weight hyaluronic acid or its salt and low-molecular-weight hyaluronic acid or its salt is 10:1-1:10, it is also lower to the stimulation of skin while compositions wrinkle improvement effect is good, when the mass ratio of high molecular weight hyaluronic acid or its salt and low-molecular-weight hyaluronic acid or its salt is 5:1-1:5, the wrinkle improvement effect of compositions is better, less to the zest of skin.
In above-mentioned composition of the present invention, described hyaluronic salt can be any salt hyaluronic disclosed in prior art, such as, in sodium salt, potassium salt, zinc salt and calcium salt one or more, and more common is hyaluroni.The effect of each hyaluronate is similar.
Above-mentioned composition of the present invention, its preparation method is: by γ-aminobutyric acid solid and low molecular weight hyaluronic acid or its salt solids mixing, fully adds polymer hyaluronic acid or its salt solid again after mixing, continues to stir until three kinds of abundant mix homogeneously of material, then cross 40 mesh sieves, obtain compositions.
In above-mentioned preparation method, γ-aminobutyric acid solid and low molecular weight hyaluronic acid or its salt solid are at room temperature uniformly mixed.
In above-mentioned preparation method, because polymer hyaluronic acid or its salt are easy to moisture absorption, in mixed process, mixture water suction, stirs after adding polymer hyaluronic acid or its salt under 45-75 DEG C and condition of negative pressure.
Above-mentioned composition of the present invention is few to skin irritation, and wrinkle removal is effective, also has the effects such as moisturizing, reparation, whitening simultaneously, therefore may be used in all types of cosmetics.Therefore, the application of above-mentioned composition of the present invention in cosmetics is also protection scope of the present invention.
In above-mentioned application, described cosmetics preferably have the cosmetics of at least one effect in crease-resistant, wrinkle removal, whitening and moisturizing, preferably have cosmetics that are crease-resistant, wrinkle removal effect.
In above-mentioned application, described cosmetics can be facial film, facial cream, emulsion, essence, astringent, eye cream or importing liquid.
In above-mentioned application, the present composition preferably as the effective ingredient of cosmetics, more preferably as the effective ingredient of at least one effect in crease-resistant in cosmetics, wrinkle removal, whitening and moisturizing.
In above-mentioned application, namely the present composition can be the single active ingredient of cosmetics, also can be used in combination with other effective ingredient, and when mixed with other effective ingredient, the effect of cosmetics is better.
Further, the cosmetics of above-mentioned composition of the present invention are comprised also within scope.This cosmetic actives or raw material comprise the above-mentioned compositions stated of the present invention.
Further, these cosmetics preferably have the cosmetics of at least one effect in crease-resistant, wrinkle removal, whitening and moisturizing, preferably have cosmetics that are crease-resistant, wrinkle removal effect.
Further, namely these cosmetics can take the present composition as single active ingredient or raw material, also can with the mixture of the present composition and other effective ingredient for effective ingredient or raw material, and when mixed with other effective ingredient, the effect of cosmetics is better.
The present composition has at least one effect in crease-resistant, wrinkle removal, whitening and moisturizing in cosmetics.
Further, in these cosmetics, γ-aminobutyric acid in compositions accounts for 0.1% ~ 15% of all components gross weight in cosmetics, preferably, γ-aminobutyric acid accounts for 0.5% ~ 10% of all components gross weight in cosmetics, preferred, γ-aminobutyric acid accounts for 5.1% ~ 10% of all components gross weight in cosmetics.At present, the most multipotency of the content of γ-aminobutyric acid in cosmetics reaches 5%, and best recommended amounts is 3%, and the present composition can make the content of γ-aminobutyric acid in cosmetics reach more than 5% and non-evident effect, Be very effective.
Further, described cosmetics can be facial film, facial cream, emulsion, essence, astringent, eye cream or importing liquid.
Beneficial effect of the present invention:
1, hyaluronic acid and γ-aminobutyric acid is comprised in the present composition, Gabanergic calm nerves conducts, lax histrionic muscles, wrinkle reduction, hyaluronic acid can infiltrate skin, rapid filling, thus play the effect reducing wrinkle, through short-term and long-term wrinkle removal experimental verification, this compositions energy wrinkle removal fast, long-acting moisturizing, makes skin rejuvenation, overcomes prior art wrinkle reduction defect slowly;
2, the present composition is through clinic trial experimental verification, significantly can improve, reduce the generally acknowledged untoward reaction such as erythema, twinge, numb gargalesthesia of γ-aminobutyric acid to skin, overcome and be used alone the stimulation of γ-aminobutyric acid to skin, improve the content of γ-aminobutyric acid in cosmetics, and the two synergism can increase compositions anti-wrinkle effect, be suitable for preparing the various cosmetics applicatory such as facial film, facial cream, emulsion, essence, essence lotion, eye cream, importing liquid.
Detailed description of the invention
Below, by specific embodiment, the present invention will be further elaborated and illustrate, following embodiment is only exemplary, does not limit its content.
In following embodiment, raw materials usedly all to have bought from market, be wherein less than 10,000 hyaluronic acid or its salt, be greater than 10,000 hyaluronic acid or its salt and γ-aminobutyric acid all from Bloomage Freda Biopharm Co., Ltd..
Embodiment 1
Composite formula is: γ-aminobutyric acid 10g, high molecular weight sodium hyaluronate (molecular weight is 1-10 ten thousand) 20g, low molecular weight sodium hyaluronate (being less than 10,000) 80g.
Its preparation method is: γ-aminobutyric acid and low-numerator sodium hyaluronate are stirred under room temperature in agitated kettle, polymer hyaluronic acid sodium is dropped into again after abundant mix homogeneously, then maintaining agitated kettle temperature is 45-75 DEG C, continue under negative pressure to stir, until three kinds of materials fully mix, cross 40 mesh sieves after mixing, obtain compositions.Said composition is Powdered.
The compositions of above-mentioned preparation can be added in cosmetics as the component of cosmetics, for the preparation of various cosmetics applicatory such as facial film, facial cream, emulsion, essence, essence lotion, eye cream, importing liquid.
The method for making of the compositions in the following example 2-12 and purposes are with embodiment 1.
Embodiment 2
Composite formula is: γ-aminobutyric acid 45g, and molecular weight is the calcium hyauronate 5g of 80-100 ten thousand, is less than the calcium hyauronate 50g of 10,000.Preparation method is with embodiment 1.
Embodiment 3
Composite formula is: γ-aminobutyric acid 100g, and molecular weight is the potassium hyaluronate 5g of 20-50 ten thousand, is less than the potassium hyaluronate 5g of 10,000.Preparation method is with embodiment 1.
Embodiment 4
Composite formula is: γ-aminobutyric acid 10g, and molecular weight is the hyaluronate sodium 20g of 50-60 ten thousand, is less than the hyaluronate sodium 30g of 10,000.Preparation method is with embodiment 1.
Embodiment 5
Composite formula is: γ-aminobutyric acid 275g, and molecular weight is the hyaluronic acid 50g of 250-300 ten thousand, is less than the hyaluronic acid 5g of 10,000.Preparation method is with embodiment 1.
Embodiment 6
Composite formula is: γ-aminobutyric acid 30g, and molecular weight is the hyaluronate sodium 60g of 20-30 ten thousand, is less than the hyaluronate sodium 20g of 10,000.Preparation method is with embodiment 1.
Embodiment 7
Composite formula is: γ-aminobutyric acid 40g, and molecular weight is the hyaluronic acid 50g of 180-200 ten thousand, is less than the hyaluronic acid 10g of 10,000.Preparation method is with embodiment 1.
Embodiment 8
Composite formula is: γ-aminobutyric acid 420g, and molecular weight is the hyaluronate sodium 50g of 30-80 ten thousand, is less than the hyaluronate sodium 10g of 10,000.Preparation method is with embodiment 1.
Embodiment 9
Composite formula is: γ-aminobutyric acid 10g, and molecular weight is the hyaluronic acid 10g of 100-120 ten thousand, is less than the hyaluronic acid 50g of 10,000.Preparation method is with embodiment 1.
Embodiment 10
Composite formula is: γ-aminobutyric acid 40g, and molecular weight is the hyaluronic acid 30g of 30-80 ten thousand, is less than the hyaluronic acid 20g of 10,000.Preparation method is with embodiment 1.
Embodiment 11
Composite formula is: γ-aminobutyric acid 20g, and molecular weight is the hyaluronic acid 20g of 50-60 ten thousand, is less than the hyaluronic acid 80g of 10,000.Preparation method is with embodiment 1.
Embodiment 12
Composite formula is: γ-aminobutyric acid 50g, and molecular weight is the hyaluronic acid 25g of 30-50 ten thousand, is less than the hyaluronic acid 25g of 10,000.Preparation method is with embodiment 1.
Embodiment 13
According to the formula in following table 1, compositions is organized in preparation more, and hyaluronic acid used is hyaluroni, for convenience of description, the hyaluronate sodium of different molecular weight is defined as hyaluronic acid A and hyaluronic acid B.
The preparation method of said composition is: γ-aminobutyric acid and low-numerator sodium hyaluronate are stirred under room temperature in agitated kettle, polymer hyaluronic acid sodium is dropped into again after abundant mix homogeneously, then maintaining agitated kettle temperature is 60-75 DEG C, continue under negative pressure to stir, until three kinds of materials fully mix, cross 40 mesh sieves after mixing, obtain compositions.
Table 1 compositions proportioning table
Application examples
In order to verify the effect of the present composition, carry out following experiment:
1, specimen in use:
Laboratory sample: the compositions 10g in Example 13, Preservative Technology for Personal Care is appropriate, adds purified water to 100ml, stirs, obtain laboratory sample 1-1 ~ 1-18.
Control sample 1: get the most normal recommended amounts 3.0g of γ-aminobutyric acid, Preservative Technology for Personal Care is appropriate, adds purified water to 100ml, stirs, to obtain final product.
Control sample 2: get γ-aminobutyric acid 9.0g, Preservative Technology for Personal Care is appropriate, adds purified water to 100ml, stirs, to obtain final product.
Control sample 3: get the hyaluronate sodium 0.5g that molecular weight is greater than 750,000, is less than the hyaluronate sodium 0.5g of 10,000, and Preservative Technology for Personal Care is appropriate, adds purified water to 100ml, stirs, to obtain final product.
Control sample 4: appropriate antiseptic, adds purified water to 100ml, stir, to obtain final product.
2, experimental technique
2.1 wrinkle removal evaluation experimental methods
Laboratory sample 1-1 ~ 1-18 is carried out controlled trial with control sample 1, control sample 2, control sample 3 and control sample 4 respectively, and adopt the mode of half face contrast, one side of something smears laboratory sample, and one side of something smears control sample.Each laboratory sample recruits 20 volunteers, and in age 30-50 year, men and women does not limit.Short-term wrinkle removal effect is before mensuration is smeared, smears the canthus wrinkle degree of depth of rear 30min, 1h, 3h and 6h, calculates wrinkle mean depth relative value.Long-term wrinkle removal effect expedition 4 weeks, measure before smearing respectively, smear after 1 week, 2 weeks, the wrinkle depth of 3 weeks and 4 weeks, calculating wrinkle mean depth relative value.
Wherein: wrinkle mean depth (Sa) relative value=× 100%
2.2 zest evaluation experimental methods
While wrinkle removal evaluation experimental, observe the zest that volunteer uses laboratory sample and control sample, point system, with reference to skin irritation test code of points in cosmetics health specification, adds that the supervisor of volunteer experiences scoring, the zest of assess sample simultaneously.The skin wound repair scoring of this experiment is in table 2.
Stimulate scoring=integration summation/tested volunteer's quantity
Table 2 skin wound repair is marked
2.3 experimental apparatus: human body skin rapid three dimensional imaging system (PRIMOS, Germany).
2.4 wrinkle removal and slow down stimulation test result
2.4.1 short-term wrinkle removal effect, in table 3.
Table 3 short-term wrinkle removal effectiveness comparison
From above-mentioned experimental result, the wrinkle removal effect of 1-1 ~ 1-17 compositions is all significantly better than control sample 1-4.Further, the content of the aminobutyric acid of 1-8,1-9,1-17 is lower than control sample 1, but their wrinkle removal effects are all better than control sample 1; The content of the aminobutyric acid of 1-1 ~ 1-7,1-10 ~ 1-16 is all lower than control sample 2, but their wrinkle removal effect is all better than control sample 2.Can be found out by the Data Comparison of 1-1 ~ 1-2 and 1-3 ~ 1-5,1-11 ~ 1-16, the hyaluronic acid of unimodal molecular weight and combined molecular weight or the introducing of its salt, the equal wrinkle removal effect that can increase γ-aminobutyric acid, but composite hyaluronic acid or its salt cooperative synergism effect more obvious.As can be seen from the contrast of 1-18 and 1-1 ~ 1-17, Gamma-propalanine content, hyaluronic acid consumption, all there is considerable influence with the selection of hyaluronan molecule amount for wrinkle removal effect.
2.4.2, long-term wrinkle removal effect
The long-term wrinkle removal effectiveness comparison of table 4
From above-mentioned experimental result, the wrinkle removal effect of 1-1 ~ 1-17 compositions is all significantly better than control sample 1-4.Further, the content of the aminobutyric acid of 1-8,1-9,1-17 is lower than control sample 1, but their wrinkle removal effects are all better than control sample 1; The content of the aminobutyric acid of 1-1 ~ 1-7,1-10 ~ 1-16 is all lower than control sample 2, but their wrinkle removal effect is all better than control sample 2.Can be found out by the Data Comparison of 1-1 ~ 1-2 and 1-3 ~ 1-5,1-11 ~ 1-16, the hyaluronic acid of unimodal molecular weight and combined molecular weight or the introducing of its salt, the equal wrinkle removal effect that can increase γ-aminobutyric acid, but composite hyaluronic acid or its salt cooperative synergism effect more obvious.As can be seen from the contrast of 1-18 and 1-1 ~ 1-17, Gamma-propalanine content, hyaluronic acid consumption, all there is considerable influence with the selection of hyaluronan molecule amount for wrinkle removal effect.
2.4.3 skin irritation evaluation result
Table 5 skin irritation result
From above-mentioned experimental result, all wrinkle removal compositionss are all significantly better than not adding hyaluronic sample and blank to the side effect of skin.Further, laboratory sample 1-1 and 1-2 has slight numb gargalesthesia to occur at different time points, laboratory sample 1-3 ~ 1-18 in the process of experiment not or extremely slight side effect occurs, as gargalesthesia, time noticeable, do not add contrast 1 and contrast 2 samples of hyaluronic acid or its salt, occur more fiber crops, itch, twinge, and in control sample 2, occur the volunteer of a small amount of erythema and edema.This shows, hyaluronic acid or its salt definite slowing down the side reaction of γ-aminobutyric acid to skin.Having there is erythema and sensation of pricking volunteer the 3rd week and the 4th week in control sample 4 (antiseptic), show that life-time service antiseptic also has ill effect to skin, and hyaluronic acid and wrinkle removal compositions of the present invention also can reduce the untoward reaction of antiseptic.
Although, above, with general illustrate and embodiment to invention has been detailed explanation, on basis of the present invention, can make some amendments or improve, this it will be apparent to those skilled in the art that.Therefore, modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. a compositions, is characterized in that: effective ingredient comprises γ-aminobutyric acid and hyaluronic acid or its salt, or effective ingredient is only γ-aminobutyric acid and hyaluronic acid or its salt.
2. compositions according to claim 1, is characterized in that: described hyaluronic acid or its salt are hyaluronic acid or its salt of unimodal molecular weight, or is the hyaluronic acid of different molecular weight or the mixture of its salt.
3. compositions according to claim 2, is characterized in that: when hyaluronic acid or its salt are hyaluronic acid or its salt of unimodal molecular weight, molecular weight is for being less than or equal to 3,000,000.
4. compositions according to claim 2, it is characterized in that: described hyaluronic acid or its salt are the mixture of high molecular weight hyaluronic acid or its salt and low-molecular-weight hyaluronic acid or its salt, the molecular weight of described high molecular weight hyaluronic acid or its salt is 1-300 ten thousand, be preferably 30-80 ten thousand, the molecular weight of described low-molecular-weight hyaluronic acid or its salt is less than 10,000.
5. compositions according to claim 4, is characterized in that: the mass ratio of high molecular weight hyaluronic acid or its salt and low-molecular-weight hyaluronic acid or its salt is 10:1-1:10, is preferably 5:1-1:5.
6. the compositions according to any one of claim 1-5, is characterized in that: the mass ratio of γ-aminobutyric acid and hyaluronic acid or its salt is 10:1-1:10, is preferably 10:1-1:5.
7. the compositions according to any one of claim 1-5, is characterized in that: described hyaluronic salt is one or more in sodium salt, potassium salt, zinc salt and calcium salt.
8. the application of the compositions according to any one of claim 1-7 in cosmetics.
9. cosmetics, is characterized in that: effective ingredient or raw material comprise the compositions according to any one of claim 1-7; Preferably, the γ-aminobutyric acid in compositions accounts for 0.1% ~ 15% of all components gross mass in cosmetics; Preferred, γ-aminobutyric acid accounts for 0.5% ~ 10% of all components gross mass in cosmetics.
10. application according to claim 8 or claim 9 or cosmetics, is characterized in that: described cosmetics are facial film, facial cream, emulsion, essence, astringent, eye cream or import liquid.
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