CN109330964A - A kind of anti-ageing anti-wrinkle composition and its preparation method and application - Google Patents
A kind of anti-ageing anti-wrinkle composition and its preparation method and application Download PDFInfo
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- CN109330964A CN109330964A CN201811529768.2A CN201811529768A CN109330964A CN 109330964 A CN109330964 A CN 109330964A CN 201811529768 A CN201811529768 A CN 201811529768A CN 109330964 A CN109330964 A CN 109330964A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
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- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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Abstract
The invention discloses a kind of anti-ageing anti-wrinkle composition and its preparation method and application, the composition includes moisturizer 0.4-10.0%, polypeptide liquid 2-10%, Hydrolyzed Collagen 3-10%；Also contain polyalcohol 3-10%, antioxidant 1-10%, preservative 0.1-3.0%, chelating agent 0.02-0.10%, anti-sensitizer 0.1-5.0%, surplus is deionized water.Anti-ageing anti-wrinkle composition of the invention has the characteristics that instant anti-wrinkle, has lasting anti-wrinkle effect concurrently, additionally it is possible to which plentiful skin increases elasticity of skin and bright color and other effects.
Description
Technical field
The invention belongs to cosmetic field, it is related to a kind of anti-ageing anti-wrinkle composition and its preparation method and application.
Background technique
Skin is made of three subcutaneous tissue, skin corium, epidermis parts, and wherein the protection of epidermis is of crucial importance, can
It is divided into 5 parts, is cuticula respectively from outside to inside, hyaline layer, stratum granulosum, has spinous layer, basal layer.
Cuticula is keratinocyte, also known as dead skin cells, there is 6-10 layers.There is protective effect, that is, prevents moisture loss, together
When prevent bacterium and harmful substance from invading again.The cuticula of health cannot be blocked up, can not be excessively thin.Cuticula is excessively thin, is not enough to
Environmental stimuli is resisted, skin is particularly easy to sensitivity, and skin moisture content is easy to run off.Cuticula is blocked up, and skin loses crystalistic sense, becomes
Must be coarse dark and gloomy, but also the absorption of skin care item nutrition can be hindered.
Hyaline layer has control skin moisture, prevents moisture loss and excessive entrance.Stratum granulosum is to prevent foreign matter from invading,
Filter ultraviolet light.There is spinous layer to be then rich in a large amount of moisture content, nutrition has cell division proliferative capacity, maintains epidermis skin
Elasticity.
Basal layer contains basal cell, and melanocyte is often accompanied between basal cell.Basal cell is undifferentiated
Juvenile cell can divide generation neonatal cell, and original cell is up elapsed, and maintain the metabolism of epidermis.Melanin
Cell generates melanin, protects skin corium.Melanin is how many and size influences skin color.It can be generated more under ultraviolet light irradiation
More melanin.
With advancing age, factors, the skin of people such as the variation of living environment, a human diet work and rest can relax, wrinkle
Increase so that many people are growing to the demand of anti-ageing anti-wrinkle, therefore anti-ageing Wrinkle removing cosmetic occupied in terms of skin care it is important
Status.
The instant anti-ageing anti-wrinkle product of Vehicles Collected from Market mainstream mainly fills skin surface gully by solid matter, reaches
The effect of short time energy anti-wrinkle.However, filling anti-wrinkle product is only merely physical pseudomorph effect, filler is easier to dispose,
To restore skin gully again, wrinkle reproduces at once, and the flexible of skin, fullness, glossiness also do not have promotion.
Today's society is a society with fast rhythm, and the instant anti-ageing anti-wrinkle product of more and more consumers demand is both
The instant anti-wrinkle of energy, persistently keeps anti-wrinkle effect, after also wanting long-time use, skin is more plentiful glossy flexible again.
Summary of the invention
The primary purpose of the present invention is that, in conjunction with skin physiology functional requirement, it is suitable to select according to skin texture feature
Raw material, scientific matching provide a kind of instant anti-wrinkle, are used for a long time to have and rebuild Skin Cell collagen network, and profound level is dispelled
Wrinkle anti-ageing, plentiful skin, raising epidermal cell moisture content, enhances skin barrier function, highlights and increases the anti-of skin elasticity
The anti-wrinkle that declines composition.
Another object of the present invention is to provide the preparation methods of above-mentioned anti-ageing anti-wrinkle composition.
A further object of the present invention is to provide the purposes of above-mentioned anti-ageing anti-wrinkle composition.
The purpose of the invention is achieved by the following technical solution:
A kind of anti-ageing anti-wrinkle composition includes following components in percentage by weight:
Moisturizer 0.4-10.0%, polypeptide liquid 2-10%, Hydrolyzed Collagen 3-10%.
The moisturizer is Sodium Hyaluronate, polyglutamic acid sodium, glycine betaine, trehalose, allantoin, sodium lactate, pyrroles
One or more of alkanone carboxylic acid sodium, D-pantothenyl aleohol, niacinamide, ceramide or amino acid；
The relative molecular weight of the Sodium Hyaluronate is 500-10000kD；The Sodium Hyaluronate of small molecule can improve angle
Matter layer permeability improves cuticula moisture content, improves the obscure appearance of skin；
The amino acid is the compound of glycine, proline, hydroxyproline, pyroglutamic acid, hydroxylysine.
The relative molecular weight of the Hydrolyzed Collagen is 500-6000kD；Small molecule Hydrolyzed Collagen can quickly seep
Saturating cuticula and other epidermis, to reach replenishing collagen, plentiful skin increases the effect of skin elasticity, reaches instant
Anti-wrinkle effect.
Polypeptide in the polypeptide liquid is acetyl group tetrapeptide -11, acetyl group octapeptide -1, acetyl group hexapeptide -3, palmityl three
One or more of peptide -5, Matrixyl -3 or oligopeptides -1；Further, the content of polypeptide is 50- in polypeptide liquid
2000ppm；
Acetyl group tetrapeptide -11 in aforementioned polypeptides can promote elasticity of skin, increase the compact degree of skin, supplement aged skin
Syndecan is insufficient, improves the adhesion strength of epidermis, and skin is made to seem the more glossy and colour of skin more evenly.
Acetyl group octapeptide -1 inhibits the catecholamine and acetylcholine mistake of skin by the synthesis of inhibition SNARE acceptor
Degree release, local block nerves transmit contraction of muscle message, loosen facial muscle, achieve the purpose that it is flat comfort microgroove, reduce by
The depth of wrinkle caused by facial expression muscle is shunk, especially around forehead and eyes.Acetyl group hexapeptide -3 can be blocked locally
Neurotransmission contraction of muscle information, influences leather bag nerve conduction, loosens facial muscle to smooth dynamic line, static line and thin
Line.
Palmityl tripeptides -5 can promote the synthesis of collagen and Glucosamine in human fibroblast, strengthen connective group
It knits, increases the skin degree of packing, promote cell activity, reduce face wrinkles, improve the colour of skin, enhance gloss and transparency.Palmityl
Pentapeptide -3 can effectively facilitate the hyperplasia of collagen, hyaluronic acid and elastic fibers, improve skin water content, and it is thick to increase skin
Degree reduces skin microgroove, increases the compact sense of skin and glossiness.
Oligopeptides -1 can quickly repair damaged skin, calm down eye wrinkle-removing, and the average age of skin histology drops in firm skin
It is low, it moisturizes the skin, enhances skin elasticity；Whitening spot-removing reduces the content of melanin and coloured corpuscle in Skin Cell, accelerates black
Plain cell metabolism falls off；Sun-proof and after-sun recovery mitigate injury of the ultraviolet radiation to skin, and the blackspot for reducing skin after shining is raw
It is long；Anti-acne removes scar, shortens the wound healing time and reduces scar being formed, have good effect to preventing and nursing acne
Fruit.
Preferably, the anti-ageing anti-wrinkle composition includes following components in percentage by weight:
Moisturizer 5-7%, polypeptide liquid 4.2-6.2%, Hydrolyzed Collagen 5.0-7.2%.
The anti-ageing anti-wrinkle composition also includes following components in percentage by weight:
Polyalcohol 3-10%, antioxidant 1-10%, preservative 0.1-3.0%, chelating agent 0.02-0.10%, anti-sensitizer
0.1-5.0%, surplus are deionized water.
The polyalcohol is glycerol, 1,2- pentanediol, 1,2- hexylene glycol, 1,2- propylene glycol, 1,3- propylene glycol, dipropyl two
One or more of alcohol, methyl propanediol, 1,3 butylene glycol or glycerin polyether -26；
The antioxidant is Vitamin C Ethyl Ether, vitamin C, L-Ascorbic Acid L-O-Phosphate, fullerene, super oxygen disproportionation
One or more of enzyme, flavonoids, beta carotene, Co-Q10, astaxanthin, plant polyphenol or N-BETA-Alanyl-L-histidine；
N-BETA-Alanyl-L-histidine has very strong oxidation resistance, has been found that the rouge for making cell membrane during oxidative stress can be removed
Fat acid excessive oxidation and the active oxygen radical and alpha-beta unsaturated aldehyde formed.
The preservative is one or more of methylparaben, Phenoxyethanol, Sensiva SC50 or Chlorphenesin；
The chelating agent is disodium ethylene diamine tetraacetate and/or tetrasodium ethylenediamine tetraacetate；
The anti-sensitizer is that dipotassium glycyrrhizinate, aloe extract, purslane extract, Baical Skullcap root P.E or cactus mention
Take one or more of object.
Preferably, the anti-ageing anti-wrinkle composition also includes following components in percentage by weight:
Polyalcohol 3.5-5.5%, antioxidant 5-6%, preservative 0.15-0.18%, chelating agent 0.05-0.08% resist
Quick dose of 0.4-4.5%, surplus are deionized water.
The preparation method of above-mentioned anti-ageing anti-wrinkle composition, comprising the following steps:
1) moisturizer, preservative and chelating agent are uniformly dispersed in advance with polyalcohol, then plus water, 80-90 DEG C of heating are stirred
It mixes to dissolution completely, is cooled to room temperature；
2) it is added remaining component one by one, stirring and dissolving is to transparent；Regulation system pH value is 6.0-6.5, after mixing, out
Material.
Above-mentioned anti-ageing anti-wrinkle composition can be applied in cosmetics；
The cosmetics include Essence, facial mask liquid, skin care stoste, eye gel, eye cream, eye cream, face cream, etc..
The present invention has the following advantages and effects with respect to the prior art:
Anti-ageing anti-wrinkle composition of the invention has the characteristics that instant anti-wrinkle, has lasting anti-wrinkle effect concurrently, additionally it is possible to plentiful flesh
Skin increases elasticity of skin and bright color and other effects.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment 1
A kind of anti-ageing anti-wrinkle composition, formula are as shown in table 1:
The raw material components of the anti-ageing anti-wrinkle composition of 1 embodiment 1 of table
The preparation process of above-mentioned anti-ageing anti-wrinkle composition is as follows:
Component A mixed at room temperature is uniformly dispersed；B component is added component A and is heated to 80- after mixed at room temperature is dispersed with stirring uniformly
90 DEG C, then insulated and stirred is cooled to room temperature to being completely dissolved；Component C sequentially adds, and stirring and dissolving is uniform；D composition regulation body
It is pH value to 6.0-6.5, obtains anti-ageing anti-wrinkle composition 1.
It by anti-ageing anti-wrinkle composition 1 and commercially available anti-ageing anti-wrinkle product, is tested for subject, acquired results such as following table
Shown in 1-1 (T-1h), table 1-2 (T-7d), table 1-3 (T-14d), table 1-4 (T-28d):
Anti-ageing anti-wrinkle composition 1 and commercially available anti-ageing product comparative evaluation of table 1-1 (T-1h) subject using the present embodiment
Can be seen that anti-ageing anti-wrinkle composition 1 and commercially available anti-ageing anti-wrinkle product from the result of table 1-1 all has instant anti-wrinkle
Effect, instant skin shine improve both aspects quite, but in terms of instant skin moisture content, skin elasticity, it is anti-ageing to dispel
Wrinkle composition 1 is substantially better than commercially available anti-ageing anti-wrinkle product.
Anti-ageing anti-wrinkle composition 1 and commercially available anti-ageing product comparative evaluation of table 1-2 (T-7d) subject using the present embodiment
Anti-ageing anti-wrinkle composition 1 and commercially available anti-ageing product comparative evaluation of table 1-3 (T-14d) subject using the present embodiment
Anti-ageing anti-wrinkle composition 1 and commercially available anti-ageing product comparative evaluation of table 1-2 (T-28d) subject using the present embodiment
From table 1-2, table 1-3, after the result of table 1-4 can be seen that subject's long-time service, anti-ageing anti-wrinkle composition 1 compares
Commercially available anti-ageing anti-wrinkle product wrinkle decrease rate, skin moisture content increase, skin elasticity improve, skin shine raising will table
It is now more excellent.
Therefore, anti-ageing anti-wrinkle composition 1 has instant anti-wrinkle effect, for a long time using with reconstruction Skin Cell collagen egg
White network, profound removing wrinkle and resisting aging, improve epidermal cell moisture content at plentiful skin, enhance skin barrier function, highlight and increase
Add skin elasticity effect.
Embodiment 2
A kind of anti-ageing anti-wrinkle composition, formula are as shown in table 2:
The raw material components of the anti-ageing anti-wrinkle composition of 2 embodiment 2 of table
The preparation process of above-mentioned anti-ageing anti-wrinkle composition is as follows:
Component A mixed at room temperature is uniformly dispersed；B component is added component A and is heated to 80- after mixed at room temperature is dispersed with stirring uniformly
90 DEG C, then insulated and stirred is cooled to room temperature to being completely dissolved；Component C sequentially adds, and stirring and dissolving is uniform；D composition regulation body
It is pH value to 6.0-6.5, obtains anti-ageing anti-wrinkle composition 2.
Subject will be used for according to anti-ageing anti-wrinkle composition 2 made from above-mentioned preparation process and commercially available anti-ageing anti-wrinkle product
It is tested, acquired results such as following table 2-1 (T-1h), table 2-2 (T-7d), table 2-3 (T-14d), table 2-4 (T-28d):
Anti-ageing anti-wrinkle composition 2 and commercially available anti-ageing product comparative evaluation of table 2-1 (T-1h) subject using the present embodiment
It can be seen that preparation-obtained anti-ageing anti-wrinkle composition 2 and commercially available anti-ageing anti-wrinkle product all from the result of table 2-1
Can preferably instant anti-wrinkle, but immediately skin shine improve ability, instant skin moisture content, skin elasticity, this several respect,
Anti-ageing anti-wrinkle composition 2 is more preferable than commercially available anti-ageing anti-wrinkle product effect.
Anti-ageing anti-wrinkle composition 2 and commercially available anti-ageing product comparative evaluation of table 2-2 (T-7d) subject using the present embodiment
Anti-ageing anti-wrinkle composition 2 and commercially available anti-ageing product comparative evaluation of table 2-3 (T-14d) subject using the present embodiment
Anti-ageing anti-wrinkle composition 2 and commercially available anti-ageing product comparative evaluation of table 2-2 (T-28d) subject using the present embodiment
From table 2-2, table 2-3, after the result of table 2-4 can be seen that subject's long-time service, anti-ageing anti-wrinkle composition 2 compares
Commercially available anti-ageing anti-wrinkle product wrinkle decrease rate, skin moisture content increase, skin elasticity improve, skin shine raising will table
It is now more excellent.
Therefore, anti-ageing anti-wrinkle composition 2 has instant anti-wrinkle effect, for a long time using with reconstruction Skin Cell collagen egg
White network, profound removing wrinkle and resisting aging, improve epidermal cell moisture content at plentiful skin, enhance skin barrier function, highlight and increase
Add skin elasticity effect.
Embodiment 3
A kind of anti-ageing anti-wrinkle composition, formula are as shown in table 3:
The raw material components of the anti-ageing anti-wrinkle composition of 3 embodiment 3 of table
The anti-ageing anti-wrinkle composition of above-described embodiment 3, preparation process are as follows:
Component A mixed at room temperature is uniformly dispersed；B component is added component A and is heated to 80- after mixed at room temperature is dispersed with stirring uniformly
90 DEG C, then insulated and stirred is cooled to room temperature to being completely dissolved；Component C sequentially adds, and stirring and dissolving is uniform；D composition regulation body
It is pH value to 6.0-6.5, obtains anti-ageing anti-wrinkle composition 3.
Anti-ageing anti-wrinkle composition 3 tests same as Example 1, anti-ageing anti-wrinkle composition with commercially available anti-ageing anti-wrinkle product efficacy
The effect of 3 the effect of is suitable with anti-ageing anti-wrinkle composition 1.
Test method involved in the embodiment of the present invention is as follows:
1, each 10 people of embodiment subject (men and women is fifty-fifty, the age between 45-60 years old, by professional training) surveyed
Examination.
2, every subject first day after same time face cleaning, thermostatic constant wet chamber (22-23 DEG C, relative humidity 70-
80%) sit quietly after 2h, guarantee it is bright and clear under, respectively with regard to subject's left eye angle, right eye angle, taken pictures, Visual face at
The item detections such as picture, skin water cut test, obtained result are T0.
3, after each detection project detection, the anti-ageing anti-wrinkle composition of about 0.3g is taken, is gently smeared 3 minutes at left eye angle
Left and right to being absorbed by the skin completely, while commercially available anti-ageing anti-wrinkle product is smeared as control in right eye angle.
4, it after subject smears, sits quietly after thermostatic constant wet chamber 1h, is taken pictures, Visual face is imaged, skin is aqueous
The item detections such as rate test, obtained result are T-1h.
5, every subject is daily after same time face cleaning, thermostatic constant wet chamber (22-23 DEG C, relative humidity 70-
80%) it sits quietly after 2h, takes the anti-ageing anti-wrinkle composition of about 0.3g, 3 minutes or so are gently smeared at left eye angle to completely by skin
It absorbs, while commercially available anti-ageing anti-wrinkle product is smeared as control in right eye angle.
6, quiet in thermostatic constant wet chamber's (22-23 DEG C, relative humidity 70-80%) after face cleaning at subject the 7th, 14,28 day
After sitting 2h, under guarantee is bright and clear, respectively with regard to subject's left eye angle, right eye angle, taken pictures, the imaging of Visual face, skin
The item detections such as water cut test, obtained result are respectively T-7d, T-14d, T-28d.
7, wrinkle decrease rate=(current wrinkle amount-T0 wrinkle amount)/T0 wrinkle amount.
8, moisture content increment rate=(current skin moisture content-T0 skin moisture content)/T0 skin moisture content.
9, elasticity improves score value: 0~2 point, not there is improvement；3-4 points, slightly improve；It 5~6 points, makes moderate progress；7~8 points,
Preferably improve；9~10 points, hence it is evident that improve.
10, glossiness improves score value: 0~2 point, not being improved；It 3-4 points, slightly improves；It 5~6 points, increases；7~8
Point, larger raising；9~10 points, hence it is evident that improve.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of anti-ageing anti-wrinkle composition, it is characterised in that include following components in percentage by weight:
Moisturizer 0.4-10.0%, polypeptide liquid 2-10%, Hydrolyzed Collagen 3-10%；
The relative molecular weight of the Hydrolyzed Collagen is 500-6000kD；
Polypeptide in the polypeptide liquid be acetyl group tetrapeptide -11, acetyl group octapeptide -1, acetyl group hexapeptide -3, palmityl tripeptides -5,
One or more of Matrixyl -3 or oligopeptides -1.
2. anti-ageing anti-wrinkle composition according to claim 1, it is characterised in that: the moisturizer be Sodium Hyaluronate,
Polyglutamic acid sodium, glycine betaine, trehalose, allantoin, sodium lactate, pyrrolidone sodium carboxylate, D-pantothenyl aleohol, niacinamide, ceramide
Or one or more of amino acid.
3. anti-ageing anti-wrinkle composition according to claim 1 or 2, it is characterised in that also include the group of following weight percent
Point: polyalcohol 3-10%, antioxidant 1-10%, preservative 0.1-3.0%, chelating agent 0.02-0.10%, anti-sensitizer 0.1-
5.0%, surplus is deionized water.
4. anti-ageing anti-wrinkle composition according to claim 3, it is characterised in that: the polyalcohol is glycerol, 1,2- penta
Glycol, 1,2- hexylene glycol, 1,2- propylene glycol, 1,3- propylene glycol, dipropylene glycol, methyl propanediol, 1,3 butylene glycol or glycerol are poly-
One or more of ether -26.
5. anti-ageing anti-wrinkle composition according to claim 3, it is characterised in that: the antioxidant is vitamin C second
Base ether, vitamin C, L-Ascorbic Acid L-O-Phosphate, fullerene, super oxygen dismutase, flavonoids, beta carotene, Co-Q10, shrimp are green
One or more of element, plant polyphenol or N-BETA-Alanyl-L-histidine.
6. anti-ageing anti-wrinkle composition according to claim 3, it is characterised in that: the preservative be methylparaben,
One or more of Phenoxyethanol, Sensiva SC50 or Chlorphenesin.
7. anti-ageing anti-wrinkle composition according to claim 3, it is characterised in that: the chelating agent is ethylenediamine tetra-acetic acid
Disodium and/or tetrasodium ethylenediamine tetraacetate.
8. anti-ageing anti-wrinkle composition according to claim 3, it is characterised in that: the anti-sensitizer be dipotassium glycyrrhizinate,
One or more of aloe extract, purslane extract, Baical Skullcap root P.E or Radix et Caulis Opuntiae Dillenii extract.
9. the preparation method of the described in any item anti-ageing anti-wrinkle compositions of claim 1-8, it is characterised in that the following steps are included:
Then plus water 1) moisturizer, preservative and chelating agent are uniformly dispersed in advance with polyalcohol, 80-90 DEG C of heating stirring is extremely
Dissolution completely, is cooled to room temperature；
2) it is added remaining component one by one, stirring and dissolving is to transparent；Regulation system pH value is 6.0-6.5, after mixing, discharging.
10. application of the described in any item anti-ageing anti-wrinkle compositions of claim 1-8 in cosmetics.
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