CN103948525B - Anti-aging active composition for epidermis - Google Patents
Anti-aging active composition for epidermis Download PDFInfo
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- CN103948525B CN103948525B CN201410167061.7A CN201410167061A CN103948525B CN 103948525 B CN103948525 B CN 103948525B CN 201410167061 A CN201410167061 A CN 201410167061A CN 103948525 B CN103948525 B CN 103948525B
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Abstract
The invention discloses an epidermal anti-aging active composition, which comprises a component A: 0.50-10.0 parts of collagen, 20-40 parts of glycerol, 3-8 parts of hydrolyzed rice protein and 3-8 parts of sweet almond seed extract in parts by weight; and (B) component: 1000-50000IU/g of sodium hyaluronate, 1000-50000IU/g of epidermal growth factor and 100-5000IU/g of keratinocyte growth factor based on the mass of the component A). The epidermal anti-aging active composition has no side effect, can effectively improve red blood streak of skin, repair skin injury, promote new cell generation, resist skin aging, has obvious scar removing and radiation resisting effects, enables the skin to show tenderness, whiteness and pureness, eliminates abnormal skin manifestations such as color spots, pigmentation and the like; can be used alone or added with other ingredients to make into various skin care products or cosmetics.
Description
Technical field
The present invention relates to cosmetic technical field, be specifically related to the anti-ageing active compound of a kind of epidermis, can be used alone or make an addition in cosmetics, skin care item.
Background technology
Skin is the maximum organ of human body, is also the first natural cover for defense of skin.The sebum film that skin surface has one deck natural, sebum film is the weakly acidic protecting film that the sebum of perspiration and the smegma of being drained by sweat gland is formed through the emulsifying of air at skin surface.It acts on the effects such as mainly moisturizing, antibacterial, sterilization.Skin aging is the skin aging phenomenon caused by natural cause or non-natural factor.
After people is born, skin histology is day by day flourishing, and function is enlivened gradually, and will start to degenerate when certain age of arrival, this degeneration is often slowly carried out unconsciously people.The growth stage of skin histology generally ends at about 25 years old, has this phase of person to be " bent angle of skin ", and carry out with aging from after this growth, Elastic fibers is gradually thicker simultaneously.The reason affecting skin aging has a lot, and as improper in age, health, spirit, nutrition, living habit, endocrine regulation, skin care etc., except the age is unique inevitably factor, all the other factors all can change.
Along with the raising day by day of people's living standard, people also more and more focus on for the maintenance of skin, the women especially liked to be beautiful, and the maintenance for skin can be described as not stint and weighs this.In order to the various skin care item of the needs meeting people, health product etc. emerge in an endless stream, however the quality of these products of market and effect very different.
Summary of the invention
For overcoming the defect of prior art, of the present invention being provides a kind of epidermis anti-ageing active compound, be applied in skin care item, the utilization rate of whitening anti-aging skin care item effective ingredient can be improved, thus reach the object improving whitening anti-aging effect, and said composition has the effect such as safety, stability.
For achieving the above object, the technical solution adopted in the present invention is as follows:
The anti-ageing active compound of a kind of epidermis, it comprises
Component A: calculate with weight ratio
Collagen protein 0.50-10.0 part, glycerol 20-40 part, hydrolysed rice albumen 3-8 part, Prunus dulcis seed extract 3-8 part;
B component: with said components A) quality be benchmark
Hyaluronate sodium 1000-50000IU/g, epidermal growth factor 1000-50000IU/g, keratinocyte growth factor 100-5000IU/g.
As a preferred embodiment of the present invention, the anti-ageing active compound of described epidermis comprises
Component A: calculate with weight ratio
Collagen protein 0.50-5 part, glycerol 20-30 part, hydrolysed rice albumen 3-5 part, Prunus dulcis seed extract 3-5 part;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 1000-10000IU/g, epidermal growth factor 1000-10000IU/g, keratinocyte growth factor 100-1000IU/g.
As a preferred embodiment of the present invention, the anti-ageing active compound of described epidermis comprises
Component A: calculate with weight ratio
Collagen protein 5-10.0 part, glycerol 30-40 part, hydrolysed rice albumen 5-8 part, Prunus dulcis seed extract 5-8 part;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 10000-50000IU/g, epidermal growth factor 10000-50000IU/g, keratinocyte growth factor 1000-5000IU/g.
As a preferred embodiment of the present invention, the anti-ageing active compound of described epidermis it comprise component A): with weight ratio calculate
Collagen protein 2-5 part, glycerol 25-30 part, hydrolysed rice albumen 4-6 part, Prunus dulcis seed extract 4-6 part;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 5000-20000IU/g, epidermal growth factor 5000-20000IU/g, keratinocyte growth factor 500-2000IU/g.
Prunus dulcis (PRUNUSAMYGDALUSDULCIS) seed extract adopted in the present invention commercially can be bought and obtain (CB3964033), also can adopt and extract with the following method: dry Prunus dulcis seed was pulverized 40-80 mesh sieve, the ratio apparatus,Soxhlet's being 1:100-200 according to the mass ratio of Prunus dulcis seed powder and water refluxes 6-15 hour then distilling under reduced pressure removing moisture in the water-bath of 60-80 DEG C.Contain various active composition in Prunus dulcis seed extract as polyhydric phenols acids, flavonoid, natural Vitamin E and unsaturated fatty acids material etc., therefore it has the effect such as non-oxidizability, antifungal.
The kind of rice protein is a lot, carries out classification comprise albumin, globulin, protein,alcohol-soluble and glutelin etc. according to its dissolubility.Because albuminised molecular weight is relatively low, and the content of its cystine is very low, not easily forms-S-S-key, more soluble in water relative to other kinds, for skin care item and and cosmetics in be easily less readily available for absorption by the skin.Therefore, described hydrolysed rice albumen is the albumin extracted with one or both mixing waters in rice, rice, Testa oryzae in the present invention.Extracting method used is the extracting method that this area is commonly used.
Hyaluronate sodium itself is thoroughly one of formation of human body skin, is the widest glutinous sugar of one acidity of people's distribution in vivo, is present in the substrate of connective tissue, has good moisture-keeping function.Preferably, the hyaluronate sodium adopted in the present invention is the low molecular weight sodium hyaluronate lower than 10kDa, advantageously in the absorption of skin, promotes new Hemapoiesis, resists skin aging.
In the present invention, epidermal growth factor (EGF) is by promoting the biosynthesis of DNA, RNA and functional protein, the macromolecular synthesis in extracellular (as hyaluronic acid, elastic fiber albumen etc.) can be promoted, increase moisture content of skin, and then increase skin elasticity, Glycerin; Subcutaneous dermal tissue is full, muscle fiber marshalling tight by promoting the functional moleculars such as skin corium emiocytosis rubber polymer fibril, polysaccharide, glycoprotein to make for EGF, thus reduces and smooth away wrinkles; EGF is by stimulating epidermis cell (comprising epithelial cell, various Interstitial cell that Various Tissues is originated) to enter cell division cycle with EGF receptors bind, some critical function gene activations, expression, secretion biological activity protein etc. in active cell, collagen fiber are impelled to be the linear alignment, the growth of epidermis cell fast regular is timely flap coverage also, after obvious acceleration beauty treatment, cosmetology and the wound healing such as other skin trauma, and keep wound surface flat smooth, spot is reduced or disappears and reduce pigmentation; In addition the propagation of epidermal growth factor to epidermis cell has stronger facilitation, use rear youthening of epidermis cell, make the less accumulation such as residual having pigment and dead cell in epidermal tissue, cutaneous manifestations is gone out and tenderly to have no time in vain, eliminate the performance of the abnormal skin such as mottle and pigmentation.Preferably, epidermal growth factor of the present invention is hEGF's lyophilized powder that Beijing Duanmu Sheng Da biotechnology Co., Ltd produces.
In the present invention, keratinocyte growth factor is by its specific receptor while stimulation epithelial cell growth, and can start the coordination signal feedback of epithelial cell to subcutaneous stroma, promote neoblastic formation, safety is good, without potential side effect; Keratinocyte growth factor all has stimulating growth splitting action to newborn or aging epithelial cell; Keratinocyte growth factor has the effect significantly except cicatrix and Antiradiation injury.Preferably, keratinocyte growth factor of the present invention be Beijing make a concerted effort Zhong Ying medical sci-tech Co., Ltd produce keratinocyte growth factor KGF2 stock solution.
A preparation method for the anti-ageing active compound of epidermis, is characterized in that, its step is as follows:
1) collagen protein, hydrolysed rice albumen are joined successively in proportion in glycerol, add Prunus dulcis seed extract after stirring, stir to obtain component A;
2) hyaluronate sodium, epidermal growth factor, keratinocyte growth factor be mixed in proportion and stir, obtaining B component;
3) by B component) join component A) in, stir.
Compared to existing technology, beneficial effect of the present invention is:
1. the anti-ageing active compound of epidermis of the present invention can effectively improve skin red blood streak, repair skin injury, promote new Hemapoiesis, resist skin aging, have significantly except cicatrix and radiation-resistant effect, cutaneous manifestations is gone out tenderly to have no time in vain, eliminate the performance of the abnormal skin such as mottle and pigmentation;
2. the anti-ageing active compound safety of epidermis of the present invention is good, and stable in properties there is no potential side effect.
3. the anti-ageing active compound of epidermis of the present invention can be used alone, and the latter adds in the products such as other skin care item (moisture retention water, skin cream) or cosmetics, improves the utilization rate of effective ingredient in skin care item and cosmetic bottle.
Below in conjunction with concrete embodiment, the present invention is described in further detail.
Detailed description of the invention
It is below specific embodiment of the present invention.
Embodiment 1
The anti-ageing active compound of a kind of epidermis, it comprises
Component A: calculate with weight ratio
Collagen protein 0.50 part, glycerol 20 parts, 8 parts, hydrolysed rice albumen, Prunus dulcis seed extract 3 parts;
B component: with said components A) quality be benchmark
Hyaluronate sodium 1000IU/g, epidermal growth factor 1000IU/g, keratinocyte growth factor 500IU/g.
Embodiment 2
The anti-ageing active compound of a kind of epidermis, it comprises
Component A: calculate with weight ratio
Collagen protein 10.0 parts, glycerol 40 parts, 3 parts, hydrolysed rice albumen, Prunus dulcis seed extract 8 parts;
B component: with said components A) quality be benchmark
Hyaluronate sodium 50000IU/g, epidermal growth factor 50000IU/g, keratinocyte growth factor 100IU/g.
Embodiment 3
The anti-ageing active compound of a kind of epidermis comprises
Component A: calculate with weight ratio
Collagen protein 5 parts, glycerol 30 parts, 5 parts, hydrolysed rice albumen, Prunus dulcis seed extract 5 parts;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 10000IU/g, epidermal growth factor 1000IU/g, keratinocyte growth factor 1000IU/g.
Embodiment 4
The anti-ageing active compound of a kind of epidermis comprises
Component A: calculate with weight ratio
Collagen protein 5 parts, glycerol 20 parts, 3 parts, hydrolysed rice albumen, Prunus dulcis seed extract 5 parts;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 1000IU/g, epidermal growth factor 10000IU/g, keratinocyte growth factor 1000IU/g.
Embodiment 5
The anti-ageing active compound of a kind of described epidermis it comprise component A): calculate with weight ratio
Collagen protein 2 parts, glycerol 25 parts, 6 parts, hydrolysed rice albumen, Prunus dulcis seed extract 4 parts;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 5000IU/g, epidermal growth factor 20000IU/g, keratin cell growth factor 2 000IU/g.
Embodiment 6
The anti-ageing active compound of a kind of epidermis it comprise component A): calculate with weight ratio
Collagen protein 2 parts, glycerol 30 parts, 4 parts, hydrolysed rice albumen, Prunus dulcis seed extract 6 parts;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 20000IU/g, epidermal growth factor 5000IU/g, keratinocyte growth factor 500IU/g.
Indexs measure
Validity check
Use crowd: age 20-45, number 100 people, is women;
There is red blood streak in various degree group 1:20 face buccal; Group 2:37 application on human skin is dry, and canthus, the corners of the mouth have microgroove in various degree; The group 3:19 people face colour of skin is uneven, dimness in various degree, partially Huang; Group 4:24 people oily skin, has comedo in various degree or pockmark.
Use after 14 days: have the red blood streak of 3 people faces to eliminate in group 1,9 people improve significantly, and others also has mitigation in various degree; Have the dry obviously improvement of 21 application on human skin in group 2,11 people's microgrooves are desalinated gradually, and others's xerosis cutis has mitigation in various degree; In group 3,5 people's colours of skin are even, and skin becomes fine and smooth, others's colour of skin be improved significantly; In group 4,19 application on human skin are fuel-displaced is controlled, and pockmark is desalinated, the obvious atrophy of comedo.
The anti-ageing active compound of epidermis of the present invention can be combined with composition general in other this areas, is processed into skin-protection products as different in beauty wash, milky lotion, emollient cream, hand cream, essence etc.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, change and the replacement of any unsubstantiality that those skilled in the art does on basis of the present invention all belong to the present invention's scope required for protection.
Claims (7)
1. the anti-ageing active compound of epidermis, it is characterized in that, it comprises
Component A: calculate with weight ratio
Collagen protein 0.50-10.0 part, glycerol 20-40 part, hydrolysed rice albumen 3-8 part, Prunus dulcis seed extract 3-8 part;
B component: with said components A) quality be benchmark
Hyaluronate sodium 1000-50000IU/g, epidermal growth factor 1000-50000IU/g, keratinocyte growth factor 100-5000IU/g.
2. the anti-ageing active compound of epidermis according to claim 1, it is characterized in that, it comprises
Component A: calculate with weight ratio
Collagen protein 0.50-5 part, glycerol 20-30 part, hydrolysed rice albumen 3-5 part, Prunus dulcis seed extract 3-5 part;
B component: with said components A) quality be benchmark
Hyaluronate sodium 1000-10000IU/g, epidermal growth factor 1000-10000IU/g, keratinocyte growth factor 100-1000IU/g.
3. the anti-ageing active compound of epidermis according to claim 1, it is characterized in that, it comprises
Component A: calculate with weight ratio
Collagen protein 5-10.0 part, glycerol 30-40 part, hydrolysed rice albumen 5-8 part, Prunus dulcis seed extract 5-8 part;
B component: with said components A) quality be benchmark
Hyaluronate sodium 10000-50000IU/g, epidermal growth factor 10000-50000IU/g, keratinocyte growth factor 1000-5000IU/g.
4. the anti-ageing active compound of epidermis according to claim 1, it is characterized in that, it comprises component A: calculate with weight ratio
Collagen protein 2-5 part, glycerol 25-30 part, hydrolysed rice albumen 4-6 part, Prunus dulcis seed extract 4-6 part;
B component: be benchmark with the quality of said components A
Hyaluronate sodium 5000-20000IU/g, epidermal growth factor 5000-20000IU/g, keratinocyte growth factor 500-2000IU/g.
5. the anti-ageing active compound of the epidermis according to any one of claim 1-4, it is characterized in that, Prunus dulcis seed extract is the product of water extraction Prunus dulcis seed, its extracting method is as follows: dry Prunus dulcis seed was pulverized 40-80 mesh sieve, the ratio apparatus,Soxhlet's being 1:100-200 according to the mass ratio of Prunus dulcis seed powder and water refluxes 6-15 hour then distilling under reduced pressure removing moisture in the water-bath of 60-80 DEG C.
6. the anti-ageing active compound of the epidermis according to any one of claim 1-4, is characterized in that, described hydrolysed rice albumen is the albumin extracted with one or both mixing waters in rice, rice, Testa oryzae.
7. the preparation method of the anti-ageing active compound of epidermis as claimed in claim 1, it is characterized in that, its step is as follows:
1) collagen protein, hydrolysed rice albumen are joined successively in proportion in glycerol, add Prunus dulcis seed extract after stirring, stir to obtain component A;
2) hyaluronate sodium, epidermal growth factor, keratinocyte growth factor be mixed in proportion and stir, obtaining B component;
3) by B component) join component A) in, stir.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104922658B (en) * | 2015-07-16 | 2018-06-15 | 广州赛莱拉干细胞科技股份有限公司 | A kind of composition and its preparation with senile-resistant efficacy |
| CN105233270A (en) * | 2015-11-12 | 2016-01-13 | 上海昊海生物科技股份有限公司 | Medicine composition for water-optical treatment and application of medicine composition |
| CN105687061B (en) * | 2016-04-15 | 2018-09-14 | 广州宝生堂化妆品有限公司 | Composition with skin repairing function |
| CN107320437A (en) * | 2017-08-30 | 2017-11-07 | 广西贵港市恒桥米业有限公司 | A kind of method that utilization selenium-rich rice prepares hand lotion |
| CN110585079A (en) * | 2019-09-09 | 2019-12-20 | 北京爸爸的选择科技有限公司 | Radiation-resistant composition containing food-borne peptide and radiation-resistant emulsion thereof |
| CN112494380A (en) * | 2020-11-18 | 2021-03-16 | 荣鼎(广东)生物科技有限公司 | Skin firming stock solution of epidermal active pentapeptide |
| CN113143782B (en) * | 2021-04-30 | 2022-08-02 | 上海百雀羚生物科技有限公司 | Cosmetic composition for improving epidermal aging and application thereof |
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