CN102406556A - Cosmetic composition favorable for keeping biological activity of epidermal growth factor (EGF) - Google Patents
Cosmetic composition favorable for keeping biological activity of epidermal growth factor (EGF) Download PDFInfo
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- CN102406556A CN102406556A CN2011103621240A CN201110362124A CN102406556A CN 102406556 A CN102406556 A CN 102406556A CN 2011103621240 A CN2011103621240 A CN 2011103621240A CN 201110362124 A CN201110362124 A CN 201110362124A CN 102406556 A CN102406556 A CN 102406556A
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Abstract
The invention discloses a cosmetic composition favorable for keeping the biological activity of an epidermal growth factor (EGF). The composition mainly comprises the EGF, hydrolyzed collagen powder, sodium hyaluronate, silk peptide powder, palmitoyl pentapeptide and carnosine. The cosmetic composition disclosed by the invention has the characteristics that polypeptides with different structures and molecules are used as main raw materials, polysaccharides are compounded, and various components are similar to the EGF in structure, thereby protecting the EGF; and under the protective action of multiple components which are reasonably combined and matched, the biological activity of the EGF in a cosmetic formula is kept.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of bioactive compositions of epidermal growth factor that helps to keep.
Background technology
The skin care item that contain epidermal growth factor (EGF) in the market; Stimulate the metabolic effect of epidermis cell through epidermal growth factor (EGF); Quicken the process that the skin regenerative cell substitutes senile cell; Impel the Skin Cell growth, keep the Skin Cell rejuvenation, thereby reach the purpose that keeps the young state of skin, radiates the vigour of youth.Because its effect is better than general skin care item composition, and natural having no side effect, so epidermal growth factor (EGF) become one of active ingredient of high-grade beauty and skin care product, and very popular on market.
But epidermal growth factor is as the bioactive peptide molecule of a kind of tool; Biological activity in the cosmetic formulations of reality relatively is hard to keep; Because composition more complicated in the cosmetic formulations and different formula components have bigger influence to its biological activity, what have possibly degrade and lose biological activity.The epidermal growth factor of only guaranteeing to add in the skin care item (EGF) is kept biological activity, could guarantee the effect of product.The biological activity that therefore how in cosmetic formulations, can better keep epidermal growth factor (EGF), be in the cosmetic field one generally be concerned about and significant problem.
Summary of the invention
The purpose of this invention is to provide a kind of bioactive cosmetic composition of epidermal growth factor (EGF) that helps to keep.
Provided by the invention a kind of to help to keep the main component of the bioactive cosmetic composition of epidermal growth factor be epidermal growth factor (EGF), hydrolytic collagen powder, hyaluronate sodium, silk peptide powder, Matrixyl and carnosine, and auxiliary element is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
The relative content of the component of preparation cosmetic composition of the present invention is:
Epidermal growth factor 0.0000001～0.000003
Hydrolytic collagen powder 0.01～4.00
Hyaluronate sodium 0.01～3.00
Silk peptide powder 0.01～5.00
Matrixyl 0.50～8.00
Carnosine 0.01～3.00
Surplus is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
The preferred relative content of the component of preparation cosmetic composition of the present invention is:
Epidermal growth factor 0.000001～0.000003
Hydrolytic collagen powder 0.20～3.00
Hyaluronate sodium 0.10～2.00
Silk peptide powder 0.10～3.00
Matrixyl 1.00～5.00
Carnosine 0.20～2.00
Surplus is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
The best relative content of the component of preparation cosmetic composition of the present invention is:
Epidermal growth factor 0.0000015
Hydrolytic collagen powder 1.50
Hyaluronate sodium 0.20
Silk peptide powder 0.80
Matrixyl 2.00
Carnosine 0.40
Surplus is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
Cosmetic composition of the present invention can adopt common process to process forms such as containing cream, frost, emulsion, astringent or gel.
In the raw material of preparation cosmetic composition of the present invention; The hydrolytic collagen powder is with animal collagen; The powdery product that processing such as used for deep-sea fish skin is raw material through clean magnificent purification, enzymolysis, filtration, concentrate, spray drying are processed; Its color is generally white or yolk yellow, and mainly is made up of the polypeptide of molecular weight between 500～20000 dalton.General molecular weight is 1000～5000 dalton, and the mean molecule quantity of performance the best use of should be in 700～1000 dalton's scopes.
Hyaluronate sodium is hyaluronic sodium-salt form, the direct-connected macromolecule polysaccharide of being made up of for disaccharidase unit glucuronic acid-N-n acetylglucosamine n.Hyaluronic acid is uniquely in the naturally occurring mucopolysaccharide not have a Sulfated polysaccharide, and hydrophilic is strong, is unbranched straight chain linear molecule, is the naturally occurring component substances of skin, with histiocyte high affinity is arranged.Made by Production by Microorganism Fermentation, molecular weight control is less than 500,000 dalton.
Silk peptide powder be fibroin after silkworm silk is come unstuck through dissolving, dialysis, purify, degraded, concentrate, processing such as spray drying and the less fibroin goods of molecular weight processed.Be rich in 18 seed amino acids, its molecular weight is generally below 2000, and the silk peptide water solublity of this molecular weight is good, and can keep the crystalline good characteristic of fibroin.Silk peptide is used for the effect that cosmetics have natural moisture preserving, damping and nutrition skin, can effectively suppress the generation of dermal melanin, and absorbability that it is good and adsorptivity make it have very excellent hair care, hair care function.
Matrixyl is meant that the derivant of the pentapeptide of being made up of in order this five seed amino acid of lysine-threonine-threonine-lysine-serine (Lys-Thr-Thr-Lys-Ser) (being abbreviated as KTTKS) is palmityl-Lys-Thr-Thr-Lys-Ser (being abbreviated as Pal-KTTKS); KTTKS is the shortest segment of collagen protein precursor I; In the dissolved process of collagen protein, be released out; Can stimulate the fibronectin in synthetic collagen protein I, III and the human body fibroblast; Primary KTTKS polypeptide is handled through palmitoylation, to improve bioavailability, strengthens it and penetrates cuticular ability.
Carnosine (alanylhistidine; Carnosine) dipeptides of being made up of Beta-alanine and histidine, carnosine have very strong oxidation resistance, and it can stably protect cell membrane; Particularly as a kind of water miscible free radical scavenger, it can stop the mistake of cell membrane to prolong oxidation reaction.With other biological species antioxidant such as V in the past
E, V
CCompare, the oxidation resistance of carnosine is stronger, thereby can delay the skin aging that causes because of free radical.In addition, carnosine also helps the reparation of skin tissue, and the skin allergy that causes because of ultraviolet is had treatment and preventive effect.
The characteristics of cosmetic composition of the present invention are that the polypeptide with different structure and molecule is a primary raw material; Composite polysaccharide; Various constituent structure are similar with EGF to be protected it thereby utilize; Reasonable combination, cooperate sharedly, the protective effect through many components reaches and in cosmetic formulations, keeps the active effect of EGF.
Through the specific embodiment and experimental studies results the present invention is described further below.
Description of drawings
Fig. 1 is the EGF biological activity variation tendency cartogram in time of product and the blank group of the embodiment of the invention 4.
The specific embodiment
Provided by the invention a kind of to help to keep the bioactive cosmetic composition of epidermal growth factor (EGF) be main component with epidermal growth factor (EGF), hydrolytic collagen powder, hyaluronate sodium, silk peptide powder, Matrixyl, carnosine, and add cosmetics matrix components emulsifying agent commonly used, oils and fats, emollient, wetting agent, gellant, glycerol, propylene glycol, antiseptic, essence and deionized water or purified water or distilled water and process.The present invention will be described to enumerate a part of specific embodiment below, is necessary to be pointed out that at this following specific embodiment only is used for the present invention is described further, and do not represent the restriction to protection domain of the present invention.Some nonessential modifications that other people make according to the present invention and adjustment still belong to protection scope of the present invention.
The skin-care gel that contains EGF:
Component and the relative content thereof of forming above-mentioned skin-care gel product are:
EGF 0.0000005
Hydrolytic collagen powder 0.20
Hyaluronate sodium 0.50
Silk peptide powder 0.60
Matrixyl 1.00
Carnosine 0.20
Carbomer 0.50
Triethanolamine 0.25
Glycerol 14.00
Antiseptic 0.10
The deionized water surplus
The method for preparing of above-mentioned skin-care gel product comprises the following steps:
(1) carbomer, hyaluronate sodium are mixed with glycerol, deionized water, stir and make its dissolving;
(2) hydrolytic collagen powder, silk peptide powder, Matrixyl, carnosine, antiseptic are added above solution stirring dissolving respectively evenly, add EGF then and stir;
(3) the triethanolamine water is dissolved into 10% solution;
(4) triethanolamine solution of being prepared is added the carbomer glycerite, the limit edged stirs, and promptly gets clear gel substrate after stirring;
(5) regulate between pH value to 6.8～7.5;
(6) above-mentioned gel is tested, qualified after, carry out fill again and promptly get skin gel skin care item.
Embodiment 2
The astringent that contains EGF:
Component and the relative content thereof of forming above-mentioned astringent product are:
EGF 0.0000008
Hydrolytic collagen powder 0.50
Hyaluronate sodium 0.02
Silk peptide powder 0.60
Matrixyl 0.50
Carnosine 0.21
Glycerol 6.00
Disodiumedetate 0.10
Germall antiseptic 0.10
Aminomethyl propanol 0.01
The deionized water surplus
The method for preparing of above-mentioned cosmetic skin-care aquatic products comprises the following steps:
(1) earlier disodiumedetate, hyaluronate sodium, glycerol, deionized water are mixed, stirring and dissolving is even;
(2) hydrolytic collagen powder, silk peptide powder, Matrixyl, carnosine, antiseptic are added above solution stirring dissolving respectively evenly;
(3) adding EGF again stirs;
(5) add aminomethyl propanol and stir, regulate between pH value to 6.5～7.5;
(6) above-mentioned astringent is crossed 200 order filter clothes after, test, qualified after, carry out fill again and promptly get the astringent skin care item that contain EGF.
Embodiment 3
The skin cream that contains EGF:
Component and the relative content thereof of forming above-mentioned skin cream are:
The A component:
PEG-100 stearate 2.00
Single glyceride 1.50
PEG-8 Cera Flava 1.50
Polydimethylsiloxane 2.00
Squalane 4.00
Isopropyl palmitate 6.00
Hexadeca-octadecyl alcohol 0.50
Methyl hydroxybenzoate 0.20
Propylparaben 0.10
The B component:
The deionized water surplus
Disodiumedetate 0.10
Glycerol 5.00
HANSHENGJIAO 0.30
The C component:
EGF 0.000001
Hydrolytic collagen powder 1.00
Hyaluronate sodium 0.30
Matrixyl 3.50
Deionized water 1.00
Silk peptide powder 1.20
Carnosine 0.80
The D component:
Germall antiseptic 0.10
Essence 0.10
The method for preparing of above-mentioned skin cream is:
HANSHENGJIAO in the B component is uniformly dispersed, after the dissolving, again A component, B component are heated to 80 ℃ respectively after, the equal prime number of biphase mixing minute; Stir cooling, cool to 40 ℃, add the uniform C component of dissolving in advance; Add the D component after stirring, stir, behind 35 ℃ of fine and smooth uniform mastic of one-tenth white; Test, qualified after, carry out fill again and promptly get skin cream.
Embodiment 4
The nourishing cream that contains EGF:
Component and the relative content thereof of forming above-mentioned nourishing cream are:
The A component:
PEG-100 stearate 2.00
Single glyceride 2.00
PEG-8 Cera Flava 2.50
Polydimethylsiloxane 2.00
Squalane 8.00
Isopropyl palmitate 6.00
White mineral oil 7.00
Hexadeca-octadecyl alcohol 1.50
Methyl hydroxybenzoate 0.20
Propylparaben 0.10
The B component:
Disodiumedetate 0.10
The deionized water surplus
Glycerol 5.00
Butanediol 5.00
HANSHENGJIAO 0.30
The C component:
EGF 0.0000015
Hydrolytic collagen powder 1.50
Hyaluronate sodium 0.20
Matrixyl 2.00
Deionized water 1.00
Silk peptide powder 0.80
Carnosine 0.40
The D component:
Germall antiseptic 0.10
Essence 0.10
The method for preparing of above-mentioned skin cream is:
HANSHENGJIAO in the B component is uniformly dispersed, after the dissolving, again A component, B component are heated to 80 ℃ respectively after, the equal prime number of biphase mixing minute; Stir cooling, cool to 40 ℃, add the uniform C component of dissolving in advance; Add the D component after stirring, stir, behind 35 ℃ of fine and smooth uniform mastic of one-tenth white; Test, qualified after, carry out fill again and promptly get skin cream.
Stability study
For the bioactive maintenance situation of EGF in cosmetic formulations, adopt the cell proliferation measurement method to measure the EGF biological activity.The cell proliferation method is according to hEGF (hEGF) growth of MEC (Balb/c 3T3 cell) to be had stimulation, explains the usefulness of EGF through measuring the change in color that is converted into first Za (Formazan) by Intramitochondrial dehydrogenase effect in the living cells.BALB/C 3T3 No.A31 is one of cell line of being separated from the BALB/C mice embryo in nineteen sixty-eight by S.A. Aaronson and G.T. Todaro.The EGF receptor of this type of cell also can combine with hEGF (hEGF), and then can promote the growth and the division of cell.The metabolism that this process produces causes dehydrogenase aggregate level increase in the cell.Dehydrogenase becomes reaction substrate MTS into red De Jia Za, and this can calculate the median effective dose (ED of hEGF for the cell growth at 490 nm place absorption peaks through the test article that measurement contains variable concentrations hEGF
50).And median effective dose (ED thus
50) detect the biologically active level of evaluation table skin growth factor.
For the proof said composition helps the active maintenance to EGF in cosmetic formulations; The corresponding product that the inventor uses the foregoing description 4 to prepare; At 25 ℃, place accelerated ageing in 6 months experiment, the EGF relative activity after 6 months in the test products for 40 ℃ respectively; Judge thus whether said composition helps the activity of EGF to keep, and result on trial is as shown in Figure 1 in cosmetic formulations.Visible by Fig. 1, said composition obviously helps the active maintenance of EGF in prescription, and do not add said composition matched group EGF activity over time, EGF is active disappear very fast.
Claims (10)
1. one kind helps to keep the bioactive cosmetic composition of epidermal growth factor; It is characterized in that; The main component of said composition is epidermal growth factor, hydrolytic collagen powder, hyaluronate sodium, silk peptide powder, Matrixyl and carnosine, and auxiliary element is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
2. the bioactive cosmetic composition of maintenance epidermal growth factor according to claim 1 is characterized in that the relative content of the component of said composition is:
Epidermal growth factor 0.0000001～0.000003
Hydrolytic collagen powder 0.01～4.00
Hyaluronate sodium 0.01～3.00
Silk peptide powder 0.01～5.00
Matrixyl 0.50～8.00
Carnosine 0.01～3.00
Surplus is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
3. the bioactive cosmetic composition of maintenance epidermal growth factor according to claim 1 is characterized in that the relative content of the component of said composition is:
Epidermal growth factor 0.000001～0.000003
Hydrolytic collagen powder 0.20～3.00
Hyaluronate sodium 0.10～2.00
Silk peptide powder 0.10～3.00
Matrixyl 1.00～5.00
Carnosine 0.20～2.00
Surplus is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
4. the bioactive cosmetic composition of maintenance epidermal growth factor according to claim 1 is characterized in that the relative content of the component of said composition is:
Epidermal growth factor 0.0000015
Hydrolytic collagen powder 1.50
Hyaluronate sodium 0.20
Silk peptide powder 0.80
Matrixyl 2.00
Carnosine 0.40
Surplus is substrate commonly used and deionized water or the purified water or the distilled water of cosmetics exterior-applied formulation.
5. each describedly helps to keep the bioactive cosmetic composition of epidermal growth factor according to claim 1-4; It is characterized in that; The powdery product that processing such as said hydrolytic collagen powder hydrolytic collagen powder is is raw material with the used for deep-sea fish skin through clean magnificent purification, enzymolysis, filtration, concentrate, spray drying are processed; Its molecular weight is between 500～20000 dalton, and protein content requires more than or equal to 90%.
6. each describedly helps to keep the bioactive cosmetic composition of epidermal growth factor according to claim 1-4; It is characterized in that; Said hyaluronate sodium is to be made by Production by Microorganism Fermentation; Molecular weight control is less than 500,000 dalton, and the content of hyaluronate sodium is more than or equal to 92%.
7. each describedly helps to keep the bioactive cosmetic composition of epidermal growth factor according to claim 1-4; It is characterized in that; Said silk peptide powder be fibroin after silkworm silk is come unstuck through dissolving, dialysis, purify, degraded, concentrate; Processing such as spray drying and the less fibroin goods of molecular weight processed, its molecular weight is below 2000, and protein content is more than or equal to 90%.
8. each describedly helps to keep the bioactive cosmetic composition of epidermal growth factor according to claim 1-4; It is characterized in that said Matrixyl is meant that the derivant of the pentapeptide of being made up of in order this five seed amino acid of lysine-threonine-threonine-lysine-serine is palmityl-Lys-Thr-Thr-Lys-Ser.
9. each describedly helps to keep the bioactive cosmetic composition of epidermal growth factor according to claim 1-4, it is characterized in that described carnosine is meant the dipeptides of being made up of Beta-alanine and histidine, and its content is more than or equal to 99%.
10. each describedly helps to keep the bioactive cosmetic composition of epidermal growth factor according to claim 1-4, it is characterized in that described cosmetic composition is cream, frost, emulsion, astringent or gel.
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|---|---|---|---|---|
| CN102793657A (en) * | 2012-08-22 | 2012-11-28 | 珀莱雅(湖州)化妆品有限公司 | Skin care product containing biological buffering agent |
| CN103070791A (en) * | 2012-09-11 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Fragrance type makeup removing emulsion and preparation method thereof |
| CN103070790A (en) * | 2012-09-11 | 2013-05-01 | 苏州宝丽洁日化有限公司 | Fragrance type makeup removing wet tissue |
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| CN103705415A (en) * | 2013-12-13 | 2014-04-09 | 华南理工大学 | Epidermal repair emulsion of meso-porous silicon carrying epidermal growth factor and preparation method thereof |
| CN103948525A (en) * | 2014-04-23 | 2014-07-30 | 广州宝生堂化妆品有限公司 | Anti-aging active composition for epidermis |
| CN104173212A (en) * | 2014-09-10 | 2014-12-03 | 百莲凯国际企业管理（北京）有限公司 | Regenerative cream and preparation technology thereof |
| CN104721067A (en) * | 2015-03-13 | 2015-06-24 | 广州市白云联佳精细化工厂 | Composition for preserving epidermal growth factor activity for long time |
| CN104856892A (en) * | 2014-11-14 | 2015-08-26 | 广州远想生物科技有限公司 | Cosmetic or skin care product preparation rich in growth factors and preparation method therefor |
| CN105233270A (en) * | 2015-11-12 | 2016-01-13 | 上海昊海生物科技股份有限公司 | Medicine composition for water-optical treatment and application of medicine composition |
| CN106539702A (en) * | 2016-11-25 | 2017-03-29 | 江苏爱西施科技服务咨询股份有限公司 | A kind of fibroin reduction frost and preparation method thereof |
| CN106913510A (en) * | 2017-04-20 | 2017-07-04 | 合肥卡迪尔化妆品有限公司 | One kind attains product collagen protein face |
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| CN108904318A (en) * | 2018-07-09 | 2018-11-30 | 陕西崇文生物科技有限公司 | It is a kind of to be repaired with collaboration EGF and moisturizing and the Essence and preparation method thereof for protecting EGF |
| CN110179688A (en) * | 2019-06-24 | 2019-08-30 | 王跃驹 | The romaine lettuce expression bioengineering factor prepares face cream |
| CN110496069A (en) * | 2019-06-05 | 2019-11-26 | 王晓霞 | A kind of poly- peptide stoste of small molecule and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073539A (en) * | 2006-05-19 | 2007-11-21 | 湖南麓谷生物技术有限公司 | Skin-moistening composition containing metal sulfur protein for improving acne repair |
| CN101721340A (en) * | 2009-10-23 | 2010-06-09 | 无限极（中国）有限公司 | Cosmetic composition for delaying skin aging |
-
2011
- 2011-11-16 CN CN2011103621240A patent/CN102406556A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073539A (en) * | 2006-05-19 | 2007-11-21 | 湖南麓谷生物技术有限公司 | Skin-moistening composition containing metal sulfur protein for improving acne repair |
| CN101721340A (en) * | 2009-10-23 | 2010-06-09 | 无限极（中国）有限公司 | Cosmetic composition for delaying skin aging |
Non-Patent Citations (1)
| Title |
|---|
| 陈立琼: "hEGF在化妆品中美白/延缓衰老功效的探索", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
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| CN110496069A (en) * | 2019-06-05 | 2019-11-26 | 王晓霞 | A kind of poly- peptide stoste of small molecule and preparation method thereof |
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Application publication date: 20120411 |