CN108635247A - Cosmetic composition containing sodium hyaluronate - Google Patents
Cosmetic composition containing sodium hyaluronate Download PDFInfo
- Publication number
- CN108635247A CN108635247A CN201810676214.9A CN201810676214A CN108635247A CN 108635247 A CN108635247 A CN 108635247A CN 201810676214 A CN201810676214 A CN 201810676214A CN 108635247 A CN108635247 A CN 108635247A
- Authority
- CN
- China
- Prior art keywords
- sodium hyaluronate
- cosmetic composition
- content
- sodium
- hyaluronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title claims abstract description 85
- 229920002385 Sodium hyaluronate Polymers 0.000 title claims abstract description 71
- 229940010747 sodium hyaluronate Drugs 0.000 title claims abstract description 69
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 239000002537 cosmetic Substances 0.000 title claims abstract description 25
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 19
- 239000002904 solvent Substances 0.000 claims abstract description 18
- 230000007062 hydrolysis Effects 0.000 claims abstract description 16
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 16
- 230000000149 penetrating effect Effects 0.000 claims abstract description 14
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 10
- 229920002674 hyaluronan Polymers 0.000 claims description 10
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- 239000011734 sodium Substances 0.000 claims description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 9
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- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 4
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- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 4
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- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
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- 239000012496 blank sample Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
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- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
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- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
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- 239000012954 diazonium Substances 0.000 description 1
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- 230000029087 digestion Effects 0.000 description 1
- IPGANOYOHAODGA-UHFFFAOYSA-N dilithium;dimagnesium;dioxido(oxo)silane Chemical compound [Li+].[Li+].[Mg+2].[Mg+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O IPGANOYOHAODGA-UHFFFAOYSA-N 0.000 description 1
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- 238000001914 filtration Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000019443 glyceryl diacetate Nutrition 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 150000002386 heptoses Chemical class 0.000 description 1
- OTGZDAXJOIALKX-UHFFFAOYSA-N hexadecyl 2-aminobenzoate Chemical class CCCCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1N OTGZDAXJOIALKX-UHFFFAOYSA-N 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
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- 239000008101 lactose Substances 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229960003194 meglumine Drugs 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
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- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- WCJLCOAEJIHPCW-UHFFFAOYSA-N octyl 2-hydroxybenzoate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1O WCJLCOAEJIHPCW-UHFFFAOYSA-N 0.000 description 1
- VIKVSUVYUVJHOA-UHFFFAOYSA-N octyl 3-phenylprop-2-enoate Chemical class CCCCCCCCOC(=O)C=CC1=CC=CC=C1 VIKVSUVYUVJHOA-UHFFFAOYSA-N 0.000 description 1
- 238000006384 oligomerization reaction Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 229940093441 palmitoyl oligopeptide Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- NIBVDXPSJBYJFT-ZQSKZDJDSA-N planteose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 NIBVDXPSJBYJFT-ZQSKZDJDSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000009938 salting Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001835 salubrious effect Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 150000003538 tetroses Chemical class 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 150000003641 trioses Chemical class 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of cosmetic compositions containing Sodium Hyaluronate.It is calculated by mass percentage, containing 3.0 15.0% Sodium Hyaluronate, 71.0 91.0% polyalcohol, 5.0 12.0% skin sense adjusting and penetrating agent and 1.0 3.0% solubilizer；Wherein, the Sodium Hyaluronate is that the micromolecule hyaluronic acid sodium of 20 40 ten thousand dalton and hydrolysis Sodium Hyaluronate that molecular weight is 8000 dalton form by middle numerator sodium hyaluronate, molecular weight that molecular weight is 80 100 ten thousand dalton.The present invention is used in cosmetics, shows prolonged humectant properties, the moistening effect of Sodium Hyaluronate can be allowed to be maximized, well solved the sticky sense of Sodium Hyaluronate, and can obtain excellent skin sense.
Description
Technical field
The invention belongs to daily chemical industry technical fields, and in particular to a kind of combination used for cosmetic containing Sodium Hyaluronate
Object.
Background technology
For Sodium Hyaluronate as a kind of Cosmetic Manufacture raw material, recognized by everybody has moisture-keeping efficacy at present, and recognizes
When being used in compounding with the Sodium Hyaluronate to different molecular weight, while obtaining better moistening effect, also have both anti-
The functions such as aging, skin repair.Currently, it is 1,800,000 that Sodium Hyaluronate class moisture-keeping cosmetics in the market, which mostly use molecular weight,
The macromolecular Sodium Hyaluronate and molecular weight of ten thousand dalton of Er Dun -220 are to divide in -150 ten thousand dalton of 1,300,000 dalton
Son amount Sodium Hyaluronate.For high molecular weight sodium hyaluronate, can only by forming the hydration shell of layer of transparent in skin surface,
Skin internal moisture is prevented to evaporate to achieve the purpose that moisturizing, still, the Sodium Hyaluronate molecular weight used is higher, skin water
Divide content lower instead, and the film that dosage is formed less is not thick enough, the effect for preventing skin internal moisture from evaporating is not achieved；This
Outside, due to the highly viscous characteristic of macromolecular Sodium Hyaluronate, dosage Gao Zehui makes cosmetics generate sticky sense when smearing, and is not easy
It is quickly absorbed by the skin, brings apparent sense of discomfort, the film formed after dry is also hard and body-sensing is uncomfortable.
Invention content
The purpose of the present invention is to provide a kind of cosmetic compositions containing Sodium Hyaluronate, can effectively solve existing skill
The shortcoming of art.
In order to achieve the above objectives, the present invention adopts the following technical scheme that：
Cosmetic composition containing Sodium Hyaluronate, is calculated by mass percentage, the hyaluronic acid containing 3.0-15.0%
The solubilizer of sodium, the polyalcohol of 70.0-91.0%, the skin sense adjusting of 5.0-12.0% and penetrating agent and 1.0-3.0%；Wherein,
The Sodium Hyaluronate is 20-40 ten thousand by middle numerator sodium hyaluronate, molecular weight that molecular weight is ten thousand dalton of 80-100
The micromolecule hyaluronic acid sodium and molecular weight that you pause are that the hydrolysis Sodium Hyaluronate of 8000 dalton forms.
Preferably, the content of the Sodium Hyaluronate is 5.0-13.0%.
Preferably, the content of the middle numerator sodium hyaluronate is 2.0-4.5%, the micromolecule hyaluronic acid sodium
Content is 2.0-4.5%, and the content of the hydrolysis Sodium Hyaluronate is 1.0-4.0%.
Preferably, the middle numerator sodium hyaluronate, micromolecule hyaluronic acid sodium and hydrolysis Sodium Hyaluronate are all made of
Prepared by microbe fermentation method, the microbe fermentation method includes enzyme cutting method.
Preferably, the hyaluronidase employed in the enzyme cutting method is to be sent out by bacillus A50CGMCC NO.5744
The bacillus hyaluronidase that ferment culture obtains.
Preferably, the polyalcohol be glycerine, butanediol, 1,3-PD, any one of dipropylene glycol or it
At least two mixture；The content of the polyalcohol is 74.0-88.0%.
Preferably, the skin sense adjusting and penetrating agent are magnesium aminosuccinate, zinc gluconate, copper gluconate, calcium pantothenate
Any one of or they at least two mixture；The content of the skin sense adjusting and penetrating agent is 5.0-10.0%.
Preferably, the solubilizer is Cremophor RH40, PEG-60 rilanit specials, PPG-26- butanol
Any one of polyethers -26, polysorbate -20 or they at least two mixture；The content of the solubilizer is 2.0-
3.0%.
The present invention is used in cosmetics, shows prolonged humectant properties, the moistening effect of Sodium Hyaluronate can be allowed to obtain
To maximization, the sticky sense of Sodium Hyaluronate is well solved, and excellent skin sense can be obtained.
Specific implementation mode
Cosmetic composition of the present invention containing Sodium Hyaluronate, is calculated by mass percentage, contains 3.0-
15.0% Sodium Hyaluronate, the polyalcohol of 70.0-91.0%, the skin sense adjusting of 5.0-12.0% and penetrating agent and 1.0-
3.0% solubilizer；Wherein, the Sodium Hyaluronate is the middle molecular weight hyaluronic acid of ten thousand dalton of 80-100 by molecular weight
Sodium, molecular weight are the micromolecule hyaluronic acid sodium of ten thousand dalton of 20-40 and the hydrolysis hyaluronic acid that molecular weight is 8000 dalton
Sodium forms.
Middle numerator sodium hyaluronate, micromolecule hyaluronic acid sodium and the hydrolysis Sodium Hyaluronate, is all made of microorganism
Fermentation method production is made, such as enzyme cutting method.The enzyme cutting method is with bacillus (Bacillus sp.) A50CGMCC
The bacillus hyaluronidase that NO.5744 fermented and cultureds obtain degrades to hyaluronic acid or its salt, and process includes preparing
Hyaluronic acid or its salting liquid, enzymolysis, inactivation, filtering, precipitation, dehydration and drying.The hyaluronic acid obtained through enzyme cutting method
Sodium has many advantages, such as that percutaneous absorbability is good, purity is high, no cytotoxicity, oxidation resistance are strong, brown stain will not occur.In the present invention
In embodiment, selection be Bloomage Freda Biopharm Co., Ltd. production Sodium Hyaluronate product.In the present invention, thoroughly
Bright matter acid sodium is 5.0%-13.0% it is preferable to use amount.Wherein, the usage amount of middle numerator sodium hyaluronate is 2.0%-
4.5%；The usage amount of micromolecule hyaluronic acid sodium is 2.0%-4.5%；The usage amount for hydrolyzing Sodium Hyaluronate is 1.0%-
4.0%.
The polyalcohol be glycerine, butanediol, 1,3- propylene glycol, any one of dipropylene glycol or they at least two
Mixture.In the present invention, polyalcohol is 74.0%-88.0% it is preferable to use amount.
The skin sense adjusting and penetrating agent are any one of magnesium aminosuccinate, zinc gluconate, copper gluconate, calcium pantothenate
Or they at least two mixture.For magnesium aminosuccinate, zinc gluconate, copper gluconate, match BIC Corp may be used
" SEPITONIC M3 " product；For calcium pantothenate, " Calcium D-Pantohenate " product of DSM N. V. may be used.This
In invention, skin sense adjusting and penetrating agent class are 5.0%-10.0% it is preferable to use amount.
The solubilizer is Cremophor RH40, PEG-60 rilanit specials, PPG-26- butylol polyethers -26, gathers
Any one of sorbitol ester -20 or they at least two mixture.For Cremophor RH40, BASF may be used
" the Cremophor RH40 solubilizer " of company；For PEG-60 rilanit specials, BASF AG may be used
" Cremophor RH60 solubilizer ".In the present invention, solubilizer is 2.0%-3.0% it is preferable to use amount.
Embodiment
Following ingredient is calculated by mass percentage.
| Serial number | Composition | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| 1 | Middle numerator sodium hyaluronate | 1.0 | 2.0 | 4.0 | 4.5 | 5.0 |
| 2 | Micromolecule hyaluronic acid sodium | 1.0 | 2.0 | 4.0 | 4.5 | 5.0 |
| 3 | Hydrolyze numerator sodium hyaluronate | 1.0 | 1.0 | 2.0 | 4.0 | 5.0 |
| 4 | Glycerine | 91.0 | 88.0 | 78.0 | 74.0 | 70.0 |
| 5 | Solubilizer | 1.0 | 2.0 | 2.0 | 3.0 | 3.0 |
| 6 | Skin sense adjusting and penetrating agent | 5.0 | 5.0 | 10.0 | 10.0 | 12.0 |
The preparation process of above-described embodiment composition is as follows：
After middle numerator sodium hyaluronate, micromolecule hyaluronic acid sodium, hydrolysis numerator sodium hyaluronate and glycerine are mixed, profit
It is stirred with blender, rotating speed is controlled at 60 revs/min, and being sufficiently stirred 20 minutes makes its substantially uniformity, and solubilizer is then added, adds
Heat makes solubilizer be completely dissolved to 60 DEG C, is cooled to 45 DEG C, and skin sense adjusting and penetrating agent is added, stirs evenly, obtains the present invention
The cosmetic composition containing Sodium Hyaluronate.
Above-mentioned middle numerator sodium hyaluronate is the HA-TLM hyaluronic acids of Bloomage Freda Biopharm Co., Ltd.
Sodium；Micromolecule hyaluronic acid sodium is the HA-TLM20-40 Sodium Hyaluronates of Bloomage Freda Biopharm Co., Ltd.；Hydrolysis is saturating
Bright matter acid sodium is the nano HA digestion oligomerization Sodium Hyaluronates of Bloomage Freda Biopharm Co., Ltd., can be auspicious by Hua Xifu
Up to biological medicine, Co., Ltd buys.Skin sense adjusting and penetrating agent, can be by hundred using the SEPITONIC M3 products of match Bick public affairs
Hao Bo companies buy.Solubilizer uses the Cremophor RH60 solubilizer of BASF AG, can be limited by the Guangzhou intelligent trade of dragon
Company buys.
Middle numerator sodium hyaluronate molecular weight used in the present invention is ten thousand dalton of 80-100, micromolecule hyaluronic acid sodium
Molecular weight be ten thousand dalton of 20-40, dosage can the molecular weight more above than 1,200,000 dalton Sodium Hyaluronate dosage it is high, equally
1,200,000 dongles can be not present while skin surface forms the hydration shell of layer of transparent, skin internal moisture is prevented to evaporate
Or more sticky effect caused by molecular weight hyaluronic acid sodium.Hydrolysis Sodium Hyaluronate molecular weight is 8000 dalton, molecule
Measure it is small, also almost without viscosity when concentration is higher, therefore can be with the addition of higher concentration to meet the salubrious skin sense of cosmetics；And
With the increase of hydrolysis hyaluronic acid concentration, the moistening effect duration increases, and hydrolysis Sodium Hyaluronate has most by force
Make the increased effect of skin moisture content.Both Sodium Hyaluronate and hydrolysis Sodium Hyaluronate are used in combination, and can play collaboration
The effect of synergy shows better moistening effect.The present invention using having the chemosmotic skin sense of promotion to adjust, can also make
Sodium Hyaluronate and the hydrolysis better osmotic absorption of Sodium Hyaluronate, play better moistening effect.
In order to improve it is aesthetic, assign skin-nourishing, prevent quality deterioration etc., can be in the model for not damaging effect of the present invention
In enclosing, in the cosmetics made of the present invention, it can be properly added as needed general used for cosmetic in addition to mentioned component
Raw material, such as：Water-soluble macromolecule, semi-synthetic water soluble polymer, Inorganic water-soluble macromolecule, ultra-violet absorber,
Metal ion chelation agent, lower alcohol, polyalcohol, monosaccharide, oligosaccharides, polysaccharide, amino acid, peptides, organic amine, preservative, pH are adjusted
Agent, vitamins, plant extraction essence, antioxidant, anti-oxidant auxiliary agent, fragrance, water etc..These ingredients can be one kind or two
Kind combination of the above.
The natural water soluble polymer can be：Arabic gum, xanthans, galactan, guar gum, locust bean gum,
Carragheen, pectin, algin, starch, amylopectin, collagen, gelatin etc..
The semi-synthetic water soluble polymer can be：Carboxymethyl starch, methylhydroxypropyl starch, methylcellulose, first
Base hydroxypropyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethylcellulose, microcrystalline cellulose, sodium alginate,
Brown alga acid propylene glycol ester etc..
The Inorganic water-soluble macromolecule can be：Bentonite, aluminum magnesium silicate, lithium magnesium silicate, montmorillonite etc..
The ultra-violet absorber can be：The p-aminobenzoic acid such as p-aminobenzoic acid monoglyceride series, menthol-N-
Salicylic acid series, the cinnamic acid monooctyl esters such as the ortho-aminobenzoic acids such as S cetyl Anthranilates series, octyl salicylate etc.
Benzophenone series such as cinnamic acid series, 4- hydroxyl -3- carboxyl benzophenones etc..Ultra-violet absorber can be used alone can also
It is used in combination.
The metal ion chelation agent can be：EDETATE SODIUM, tetra- sodium of EDTA etc..
The lower alcohol can be：Ethyl alcohol, isopropanol etc..
The polyalcohol can be：Glycerine, propylene glycol, butanediol, sorbierite etc..
The monosaccharide example can be：The pentoses such as tetroses, the D-arabinoses such as the triose such as D- glyceraldehyde, D- erythroses, D- grapes
The amino sugars such as the desoxysugars such as the heptose such as the hexoses such as sugar, aldopentose, L-fucose, d-glucosamine, D- galacturonic acids etc.
Uronic acid etc..
The oligosaccharides can be:Lactose, raffinose, planteose etc..
The polysaccharide can be：Chondroitin sulfate, chitosan, galactan etc..
The amino acid can be the ammonia such as basic amino acids, the glutathione such as the neutral amino acids such as threonine, sulfydryl lysine
Base acid derivative etc..
The peptides can be：Dipeptides diaminobutyryl benzyl amide diacetin, Matrixyl -4, oat
(AVENASATIVA) peptide, acetyl group octapeptide -3, carnosine, glutathione, dipeptides -2, palmityl tetrapeptide -7, palmitoyl oligopeptide, palm fibre
Palmitic acid acyl tripeptides -1 etc..
The organic amine can be：Monoethanolamine, triethanolamine, 2-Amino-2-methyl-1,3-propanediol etc..
The preservative can be：Methyl hydroxybenzoate, Phenoxyethanol, diazonium imidazolidinyl urea, iodopropynyl alcohol butyl meglumine acid
Ester, Chlorphenesin, sodium benzoate etc..
The pH adjusting agent can be：Sodium hydroxide, triethanolamine, citric acid etc..
The vitamins can be：Vitamin A, vitamin C, vitamin E, pantothenic acid, vitamin B3 and their derivative
Object etc..
The plant extraction essence can be：Aloe, witch hazel, cucumber, lemon, lavender, rose etc..
The antioxidant can be：Tocopherols, dibutyl hydroxy toluene, butylated hydroxy anisole, gallate ester
Deng.
The antioxidant auxiliary agent can be：Phosphoric acid, maleic acid, malonic acid, phytic acid, EDTA etc..
Application Example
Moisturizing essence is prepared using the cosmetic composition of the present invention containing Sodium Hyaluronate, be formulated (with
Under each ingredient be calculated by mass percentage) it is as follows：
The preparation process of above-mentioned moisturizing essence is as follows：
1, kettle is added in deionized water, is warming up to 80 DEG C, insulated and stirred 20 minutes.
2 and then cooling, 60 DEG C are cooled to, the present composition is added, stirring to composition is completely dissolved；
3, continue to cool down, be cooled to 45 DEG C, essence and preservative is added, after stirring 30 minutes, inspection discharges after qualified.
In order to which the long-acting moisturizing and excellent skin sense, this application embodiment that prove the present invention have carried out test below：
Sodium Hyaluronate moisturizing essence is prepared according to the formula of embodiment 1 to 5, as experiment preparation, and respectively
It is named as sample 1, sample 2, sample 3, sample 4 and sample 5；In addition it prepares without SEPITONIC M3 and Cremophor RH60
The Sodium Hyaluronate moisturizing essence of solubilizer as experiment preparation, and is named as reference substance 1, reference substance 2, compares 3, is right
According to 4 and reference substance 5；The moisturizing essence without the present composition is prepared again, as experiment preparation, is named as blank group.
Specific practice is：
One, moistening effect is tested：
Select 6 groups of subjects, women conduct on probation object of the age at 23-35 Sui.Subject is in constant temperature and humidity (temperature
(22 ± 1) DEG C, humidity (50 ± 10) %) in environment rest 30min and choose it is suitable apply sample region, measure T0 and (use product
Before) when first data, painting sample is carried out to the region chosen in its double forearm according to random table, by (2.0 ± 0.1) mg/cm2 survey
The dosage of test agent carries out single smearing, and entire experiment process carries out in constant-temperature constant-humidity environment, and respectively in spread product
T30min afterwards, T60min, T120min and T240min carry out non-invasive Instrument measuring, measurement keratoderma water to recipient site
Content is closed, percutaneous moisture loss rate simultaneously records.
1, the measurement of keratoderma hydration level analysis (CAP), the equipment of use is MOISTUREMETERSC MSC1212
(DELFIN).Clinical practice OISTUREMETERSC MOISTUREMETERSC measure arm keratoderma and are hydrated water content.
Numerical value is higher, indicates that keratoderma hydration levels are higher, shows that the moistening effect of product is better.
2, the measurement of the percutaneous moisture loss analysis (TEWL) of skin, the equipment used is TAPOETER SWL5167
(DELFIN).Clinical practice TAPOMETER measures arm transepidermal water loss rate.Numerical value is smaller, indicates that skin barrier is better, shows to produce
The water lock effect of product is better.
Table 1：Keratoderma hydration content
Table 2：Percutaneous water loss rate
In preferred embodiments, the skin relative to blank group processing, with T30min, T60min after sample,
T120min, T240min are compared with baseline value (T0), and keratoderma hydration content obviously increases, and percutaneous water loss obviously subtracts
It is few；Relative to the skin of control group processing, keratoderma hydration content also obviously increases.The present invention also provides skin opposite
The increase of longer time moisture-keeping function and other advantageous effects, for example, being up to 8,12 and 24 hours, without lacking for existing preparation
For example sticky sense of point or the not enough soft feeling of silk cunning.
As a result it demonstrates the preferred embodiment of the invention that embodiment 1-5 is represented and excellent skin moisture-keeping characteristic is provided,
After 30 minutes and 1 hour, the moistening effect of skin improves significantly, far better than the result of reference examples and blank sample.It should
As a result the prompt present composition provides wondrous and unexpected collaboration moistening effect, because wherein component individually makes
With or do not add skin sense adjusting and penetrating agent class and optimum efficiency is all not achieved in solubilizer class.
Two, skin sensing examination：
Select 25 groups of subjects, women conduct on probation object of the age at 23-55 Sui.Subject is right according to using effect
The indices of test product are given a mark, and are given a mark successively according to degree is liked：5 points enjoy a lot, and 4 points are preferred, 3 point one
As, 2 points are compared and are not liked, and 1 point does not like, and 5 points are satisfaction peak.
From the point of view of test result, the preferred embodiment of the invention that embodiment 1-5 is represented improves Sodium Hyaluronate
Sticky sense, absorbability, silk smooth felling and soft feeling bring excellent skin sense, are more liked by consumer.
Claims (8)
1. the cosmetic composition containing Sodium Hyaluronate, which is characterized in that be calculated by mass percentage, contain 3.0-15.0%'s
The solubilising of Sodium Hyaluronate, the polyalcohol of 70.0-91.0%, the skin sense adjusting of 5.0-12.0% and penetrating agent and 1.0-3.0%
Agent；Wherein, the Sodium Hyaluronate is by middle numerator sodium hyaluronate, the molecular weight that molecular weight is ten thousand dalton of 80-100
The micromolecule hyaluronic acid sodium and molecular weight of ten thousand dalton of 20-40 are that the hydrolysis Sodium Hyaluronate of 8000 dalton forms.
2. the cosmetic composition according to claim 1 containing Sodium Hyaluronate, which is characterized in that the hyaluronic acid
The content of sodium is 5.0-13.0%.
3. the cosmetic composition according to claim 2 containing Sodium Hyaluronate, which is characterized in that the middle molecule is saturating
The content of bright matter acid sodium is 2.0-4.5%, and the content of the micromolecule hyaluronic acid sodium is 2.0-4.5%, and the hydrolysis is transparent
The content of matter acid sodium is 1.0-4.0%.
4. the cosmetic composition according to any one of claims 1 to 3 containing Sodium Hyaluronate, which is characterized in that described
Middle numerator sodium hyaluronate, micromolecule hyaluronic acid sodium and hydrolysis Sodium Hyaluronate are all made of microbe fermentation method preparation, described
Microbe fermentation method includes enzyme cutting method.
5. the cosmetic composition according to claim 4 containing Sodium Hyaluronate, which is characterized in that in the enzyme cutting method
Used hyaluronidase is the bacillus hyaluronic acid obtained by bacillus A50 CGMCC NO.5744 fermented and cultureds
Enzyme.
6. the cosmetic composition according to claim 1 containing Sodium Hyaluronate, which is characterized in that the polyalcohol
For any one of glycerine, butanediol, 1,3- propylene glycol, dipropylene glycol or they at least two mixture；The polyalcohol
Content be 74.0-88.0%.
7. the cosmetic composition according to claim 1 containing Sodium Hyaluronate, which is characterized in that the skin sense tune
Section and penetrating agent be magnesium aminosuccinate, zinc gluconate, copper gluconate, any one of calcium pantothenate or they at least two mixing
Object；The content of the skin sense adjusting and penetrating agent is 5.0-10.0%.
8. the cosmetic composition according to claim 1 containing Sodium Hyaluronate, which is characterized in that the solubilizer
For any in Cremophor RH40, PEG-60 rilanit specials, PPG-26- butylol polyethers -26, polysorbate -20
Kind or they at least two mixture；The content of the solubilizer is 2.0-3.0%.
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| CN110279626A (en) * | 2019-07-15 | 2019-09-27 | 上海新高姿化妆品有限公司 | With the cosmetic composition and preparation method thereof for cooperateing with long-acting moistening effect |
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