CN107485598B - It is a kind of to thicken pearl toner and preparation method thereof certainly - Google Patents

It is a kind of to thicken pearl toner and preparation method thereof certainly Download PDF

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Publication number
CN107485598B
CN107485598B CN201710765258.4A CN201710765258A CN107485598B CN 107485598 B CN107485598 B CN 107485598B CN 201710765258 A CN201710765258 A CN 201710765258A CN 107485598 B CN107485598 B CN 107485598B
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toner
pearl
thickening
additional amount
skin
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CN107485598A (en
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张金金
林娜妹
刘向前
刘德海
张伟雄
张伟杰
张楚标
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Guangdong Danz Group Co Ltd
Guangzhou Keneng Cosmetic Research Co Ltd
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Guangdong Dan Zi Group Co Ltd
GUANGZHOU BAIYUN LIANJIA FINE CHEMICALS FACTORY
Guangzhou Keneng Cosmetic Research Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
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    • A61K8/733—Alginic acid; Salts thereof
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/48—Thickener, Thickening system

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Abstract

The present invention provides a kind of from thickening pearl toner and preparation method thereof.By described from terms of the weight percent of thickening pearl toner total weight, including following components: film forming agent: 0.01-1.0%；Pearl: 0.05-5%；Polyalcohol: 3-20%；Skin conditioning agent: 0.0001-0.005%；Moisturizing additive: 0.01-3.0%；Acidity regulator: 0.001-0.05%；Water: 71-95%.Of the invention has slow thickening effect from thickening pearl toner, viscosity will be slow rising, while have moisturizing, whitening and anti-acne effect, and without additional addition cosmetics Common Preservatives, facilitate the barrier and maintenance ability of promotion skin, mild safety is suitble to be used for a long time.

Description

It is a kind of to thicken pearl toner and preparation method thereof certainly
Technical field
The present invention relates to a kind of from thickening pearl toner and preparation method thereof, belongs to cosmetic field.
Background technique
Currently, the common toner there are many state, such as transparent lotions, milky milk water are suspended with pearl on the market Mating plate or particle or petal water, upper layer is oil phase or lotion and lower layer is the Double-layer water of water phase.Common above-mentioned toner glues Degree is all relatively low, and consistency will not change in use with the variation of time.Commercially available common cosmetics simultaneously In, it is added hydrolyzed pearl extract as whitening composition, Yin Qiyi causes product to turn yellow, and causes it to add in the product limited System.
Patent CN106551879A provides a kind of bird's nest toner and its manufacturing method, by Denatonium Benzoate, butanediol, sea Algae sugar, propylene glycol, glycerol, ethyl alcohol, hydroxyethyl cellulose, dimethyl silicone polymer, potassium sorbate, sorbic acid, ethylhexyl are sweet Oil, hyaluronic acid, polyethylene glycol-8, glycerol heteroside, ascorbic acid phosphoric acid esters and solvent are placed in container, are heated to 90 DEG C simultaneously Stirring and dissolving；42 DEG C are cooled to after heat preservation 15min；Be added light rain birds nest extract, brewer's yeast fungus extract, hydrolyzed pearl and Essence stirs 3-10min；Lemon acid for adjusting pH is added；Defoaming is stood, is cooled to room temperature, filling is finished product.The bird's nest toner In contain hydrolyzed pearl extract, be a common moisturizing lotion, do not have from thickening effect.
Summary of the invention
Problems to be solved by the invention
The purpose of the present invention is to provide a kind of from thickening pearl toner and preparation method thereof.Certainly the thickening pearlization Adornment water has from thickening function, and viscosity will be slow rising, while have moisturizing, whitening and anti-acne multiple effect, moisten skin, It is soft and soft, enhance skin barrier function.
The solution to the problem
The present invention provides a kind of thickening pearl toner certainly, with described from the weight percent for thickening pearl toner total weight Than meter, including following components:
Film forming agent: 0.01-1.0%；
Pearl: 0.05-5%；
Polyalcohol: 3-20%；
Skin conditioning agent: 0.0001-0.005%；
Moisturizing additive: 0.01-3.0%；
Acidity regulator: 0.001-0.05%；
Water: 71-95%.
Certainly thickening pearl toner according to the present invention, with described from the weight percent for thickening pearl toner total weight Meter,
The additional amount of the film forming agent is 0.1-0.8%, preferably 0.15-0.5%；
The additional amount of the pearl is 0.05-4%, preferably 0.5-2.5%；
The additional amount of the polyalcohol is 5-18%, preferably 8-15%；
The additional amount of the skin conditioning agent is 0.0003-0.005%, preferably 0.0008-0.005%；
The additional amount of the moisturizing additive is 0.05-2.8%, preferably 0.1-2.5%；
The additional amount of the acidity regulator is 0.002-0.05%；Preferably 0.005-0.03%；
The additional amount of the water is 75-93%, preferably 80-91%.
Certainly thickening pearl toner according to the present invention, the film forming agent includes in carragheen, gellan gum and sodium alginate A combination of one or more.
Certainly thickening pearl toner according to the present invention, the pearl are pearl particles or pearl powder.
Certainly thickening pearl toner according to the present invention, the polyalcohol includes 1,3-PD, methyl propanediol, dipropyl One or more of glycol, 1,2- pentanediol, 1,3 butylene glycol, glycerol and hexylene glycol；Preferably include methyl propanediol, The combination of one or more of dipropylene glycol, 1,2- pentanediol and 1,3 butylene glycol.
Certainly thickening pearl toner according to the present invention, the skin conditioning agent includes one of quaternary ammonium salt -73, kojic acid Or two kinds of combination.
Certainly thickening pearl toner according to the present invention, the moisturizing additive includes trehalose, pulullan polysaccharide, malt The combination of one or more of sugar alcohol, antierythrite, urea and glycine betaine.
Certainly thickening pearl toner according to the present invention, the acidity regulator includes citric acid, lactic acid, succinic acid and plant The combination of one or more of sour sodium.
Certainly thickening pearl toner according to the present invention, the pH value from thickening pearl toner is between 4-6.
The present invention also provides a kind of preparation methods according to the present invention for thickening pearl toner certainly, including will be described from increasing The step of each component mixing of thick pearl toner.
The effect of invention
Of the invention to have slow thickening effect from thickening pearl toner, viscosity will be slow rising, at the same have moisturizing, Whitening and anti-acne effect, and without additional addition cosmetics Common Preservatives, facilitate the barrier and maintenance energy that promote skin Power, mild safety are suitble to be used for a long time.
Specific embodiment
It will be detailed below various exemplary embodiments, feature and the aspect of the disclosure.Dedicated word " example herein Property " mean " being used as example, embodiment or illustrative ".Here as any embodiment illustrated by " exemplary " should not necessarily be construed as Preferred or advantageous over other embodiments.
In addition, giving numerous details in specific embodiment below in order to which the disclosure is better described. It will be appreciated by those skilled in the art that without certain details, the disclosure equally be can be implemented.In other example, Method well known to those skilled in the art, means, equipment and step are not described in detail, in order to highlight the master of the disclosure Purport.
The present invention provides a kind of thickening pearl toner certainly, with described from the weight percent for thickening pearl toner total weight Than meter, including following components:
Film forming agent: 0.01-1.0%；
Pearl: 0.05-5%；
Polyalcohol: 3-20%；
Skin conditioning agent: 0.0001-0.005%；
Moisturizing additive: 0.01-3.0%；
Acidity regulator: 0.001-0.05%；
Water: 71-95%.
Film forming agent from thickening pearl toner, can play moist, soft, fine and smooth and without glutinous soapy feeling of the invention Form a film water retention.In the present invention, the film forming agent include one or both of carragheen, gellan gum and sodium alginate with On combination.
Carragheen also known as carrageenan, deer horn phycocolloid, Irish green moss glue, are by galactolipin and Anhydrogalactose institute group At have sulfuric ester biological polyoses class molecule.Due to the difference of wherein sulfuric ester combining form, generally lead κ-type to be used, Three kinds of ι-type, λ-type carragheens.The colloidal sol that low viscosity is formed when the concentration of carragheen is low has thickening effect close to Newtonian fluid Fruit.Wherein, ι-type carragheen and calcium binding, which are capable of forming, has better thixotropic gel.Of the invention is precious from thickening Film forming agent in pearl toner is preferably carragheen, more preferably ι-type carragheen.
Gellan gum main component is the film forming agent that glucose, rhamnose and glucuronic acid combine.In natural Gao Yi With the presence of acetyl group and glycerol acidic group in acyl structure, they are all located on the same glucosyl group, and each average repetition is tied Structure has a glycerol acidic group, and every two repetitive structure has an acetyl group.In the presence of calcium ion, it is capable of forming harder crisp Gel.
Sodium alginate is by guluronic acid (being denoted as G sections) and its two kinds of stereoisomer mannuronic acid (being denoted as M sections) The sodium salt that structural unit is constituted, (MM sections, GG sections and MG sections) in a manner of three kinds of both structural units pass through α-Isosorbide-5-Nitrae glycosidic bond chain It connects, to form a kind of unbranched linear block copolymers.Sodium ion is easy to replace with calcium ion in sodium alginate, Form gel.Moreover, having mild sol-gel process, good biocompatibility and very strong water holding capacity.
In the present invention, by described from terms of the weight percent of thickening pearl toner total weight, the additional amount of film forming agent Between 0.01-1.0%, preferably between 0.1-0.8%, more preferably in 0.15-0.5%.The additional amount of film forming agent is in 0.01- When between 1.0%, be added into toner, can make skin it is moist, it is soft, fine and smooth and do not stick it is greasy, in skin surface shape At one layer of moisturizing water lock film.
In addition, it is preferably not included that such as in film forming agent of the invention: hydroxyethyl cellulose, xanthan gum, agar, Scleroglucan, Hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers, ammonium acryloyl taurate/VP copolymer etc. have phase Like the thickener of function.But under the premise of the film forming agent containing the application, from thicken pearl toner in can wrap containing Suitable above-mentioned thickener.
In general, the inorganic constituents of pearl is mainly calcium carbonate, magnesium carbonate.Also contain L-aminobutanedioic acid, threonine, silk ammonia Acid, glutamic acid, glycine, alanine, cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, 17 kinds of amino acid such as histidine, arginine, proline, in addition, also containing 30 various trace elements, taurine, dimension abundant life Element, peptides.Pearl is added in the present invention, the effect of thickening can be produced from, and a variety of amino acid and Wei Sheng can be supplemented Element etc., so that skin can be realized the effect of whitening oil-control etc..
In the present invention, the pearl is pearl particles or pearl powder；Preferably pearl particles.It is added when by pearl particles It can be slowly dissolved to of the invention from thickening pearl toner, so that release and offer bivalent cation, are in contact with it Film forming agent forms gel, and the local aqua viscosity of pearl particles increases.Under extraneous physical force each time, such as make toppling over With from when thickening pearl toner, the dilution of gel around pearl particles can be accelerated to diffuse in whole bottle aqua.
As the access times from thickening pearl toner increase, increasing should be will be slow from the consistency of thickening pearl toner Add, viscosity will slowly rise, that is, be produced from thickening effect.When the pearl in water is not redissolved, from the viscous of thickening pearl toner Degree then keeps a certain range no longer to fluctuate.In this certainly thickening pearl toner use process, can be to consumer's bring The usage experience of more textured sense and entertaining sense.Pearl itself soluble organic matter is made preferably to be dissolved in this from increasing simultaneously In thick pearl toner, use effect of product is enriched.
In addition, also may be implemented from thickening effect, when thickening rate compared to using pearl particles when selecting pearl powder Fastly, the state for being in a kind of viscosity stabilization faster from thickening pearl toner can be made.Also, pearl itself solubility is organic Substance can be similarly dissolved in toner.
Pearl particles and pearl powder of the invention are preferably fresh water pearl particle or fresh water pearl powder.
In the present invention, by described from terms of the weight percent of thickening pearl toner total weight, the addition of the pearl Amount is between 0.05-5%, preferably between 0.05-4%, more preferably between 0.5-2.5%.When the additional amount of pearl exists When between 0.05-5%, the effect of thickening can be produced from, and a variety of amino acid and vitamin can be supplemented etc., so that skin Skin can be realized the effect of whitening oil-control etc..
Polyalcohol of the invention includes 1,3- propylene glycol, methyl propanediol, dipropylene glycol, 1,2- pentanediol, 1,3- fourth two One or more of alcohol, glycerol and hexylene glycol.Wherein, 1,3-PD is natural products, will not cause skin irritatin Or allergy, product performance of keeping humidity can be enhanced.1,3 butylene glycol is small molecule moisturizing ingredient.Dipropylene glycol is small to skin irritation Moisturizer.Methyl propanediol has good moistening effect, while providing salubrious skin sense.Glycerol has strong hygroscopicity, can Slowed down with the speed that distributes of the moisture allowed on skin, and can suitably absorbed water from air.1,2- pentanediol is good Moisturizer, additionally it is possible to so that reducing preservative usage amount in cosmetics, and the irritation of protective system is effectively reduced, is suitble to Nursing for sensitive delicate skin and aging dry skin.
Preferably, polyalcohol of the invention includes in methyl propanediol, dipropylene glycol, 1,2- pentanediol and 1,3-BDO A combination of one or more.
In the present invention, by described from terms of the weight percent of thickening pearl toner total weight, the polyalcohol adds Enter amount between 3-20%, preferably between 5-18%, more preferably between 8-15%.
Skin conditioning agent of the invention includes the combination of one or both of quaternary ammonium salt -73, kojic acid.
Quaternary ammonium salt -73 is a kind of yellow solid or crystal, has antibacterial activity, can reduce the generation of acne, acne, from And make the pearl toner of thickening certainly of the invention that there is certain acne-removal function.In addition, quaternary ammonium salt -73 may be used also in the present invention To play certain antisepsis, there is certain killing ability to bacterium, staphylococcus, Escherichia coli etc..Therefore, of the invention In can not add additional preservative, such as Phenoxyethanol, methyl hydroxybenzoate can be added without etc..
In the present invention, by described from terms of the weight percent of thickening pearl toner total weight, the skin conditioning agent Additional amount between 0.0001-0.005%, preferably between 0.0003-0.005%, more preferably in 0.0008-0.005% Between.
Moisturizing additive of the invention includes trehalose, pulullan polysaccharide, maltitol, antierythrite, urea and beet The a combination of one or more of alkali.
Trehalose has efficient moisture-keeping functions, can be under the mal-conditions such as high temperature, high and cold and dry dehydration in cell Surface forms special protective film, and biomolecular structure is not destroyed in effective protection skin cell, and it is suitable further to promote skin Answer environment capacity and oxidation resistance.
Pulullan polysaccharide is more by similar glucan, the water-soluble vitamins of xanthan gum of Aureobasidium pullulans fermenting and producing Sugar.The polysaccharide is more by the straight-chain that the maltotriose repetitive unit of α -1,4- glucosides key connection is polymerized through α -1,6- glycosidic bond Sugar.Pulullan polysaccharide has good moisturizing moisturizing effect.
Maltitol can be a kind of sugar alcohol made of Starch Hydrolysis and hydrofining.It is resistance to good hygroscopicity Heat and acid-resistant stability.Maltitol can be effectively improved the pliability of skin while moisturizing.
Antierythrite is by a kind of fermented obtained white crystal of glucose, is good natural moisturizer, can be significant Increase moisture of skin, keep the barrier function of skin, promotes skin flexibility and flexibility.
Urea (cosmetics-stage) helps to reduce skin water loss, itself is present in the cuticula of skin, belongs to In the main component of skin natural moisturizing factor.Urea has effects that outstanding moisturizing and soft cutin, moisturizes the skin simultaneously Promote the penetrating power of other compositions.
Glycine betaine helps to maintain Premeabilisation of cells pressure, can provide large quantity of moisture for skin, be a kind of good moisturizer.
In the present invention, by described from terms of the weight percent of thickening pearl toner total weight, the moisturizing additive Additional amount between 0.01-3.0%, preferably between 0.05-2.8%, more preferably between 0.1-2.5%.The moisturizing It when the additional amount of additive is between 0.01-3.0%, can bring that silk is sliding, moist and instant moisturizing effect to skin, promote flesh Skin water conservation and barrier ability.
In the present invention, the acidity regulator include one or both of citric acid, lactic acid, succinic acid and sodium phytate with On combination.By adding acidity regulator, pH value of the present invention is fluctuated in a certain range, is made up from pearl is thickened Water is weakly acidic, will not damage to skin, and is conducive to the dissolution of pearl particles or pearl powder.In view of to skin Mildness etc., acidity regulator of the invention are preferably citric acid.
In the present invention, by described from terms of the weight percent of thickening pearl toner total weight, the acidity regulator Additional amount is between 0.001-0.05%, preferably between 0.002-0.05%；More preferably between 0.005-0.03%.
In general, can make the pH value for thickening pearl toner between 4.0-6.0.
In addition, of the invention from thickening pearl toner, preferably without just like CaCl2, the inorganic salts ingredients such as NaCl.
In the present invention, used water is preferably deionized water.With described from the weight for thickening pearl toner total weight Percentages, the additional amount of the water are 71-95%；Preferably 75-93%, more preferably 80-91%.
The present invention also provides a kind of described from the preparation method for thickening pearl toner according to the present invention, including will it is described from The step of thickening each component mixing of pearl toner.
Specifically, the preparation method comprises the following steps:
A: deionized water being added into reactor, is added with stirring the film forming agent good with disperse polyol, and sufficiently dissolution is equal It is even；It is heated to 80-85 DEG C, after keeping the temperature 15-25min, is cooled to 40-50 DEG C.
B: and then moisturizing additive is added into above-mentioned emulsion pot and is evenly stirred until dissolution；It is added with polyalcohol solubilising Skin conditioning agent stirs.
C: being added acidity regulator, adjusts and obtains toner base-material after filtering and discharging after pH is 4.0-6.0.
D: after detection is qualified, the pearl cleaned through deionized water with 75% ethanol disinfection is added into each Packaging Bottle Grain, it is filling, it obtains from thickening pearl toner.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and should not be taken as limiting the scope of the invention.It is not specified in embodiment specific Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is It can be with conventional products that are commercially available.
Embodiment 1-10
After being weighed according to the weight percentage of each component in the following table 1-2, it is prepared according to following step precious from thickening Pearl toner.
From thickening pearl toner the preparation method is as follows:
A: deionized water being added into emulsion pot, is added with stirring the film forming agent good with disperse polyol, makes sufficiently to dissolve Uniformly；85 DEG C are then heated to, after keeping the temperature 20min, is cooled to 45 DEG C.
B: and then moisturizing additive is added into above-mentioned emulsion pot and is evenly stirred until dissolution；It is added with polyalcohol solubilising Skin conditioning agent stirs.
C: being added acidity regulator, adjusts and obtains toner base-material after filtering and discharging after pH is 4.0-6.0.
D: after detection is qualified, the pearl cleaned through deionized water with 75% ethanol disinfection is added into each Packaging Bottle Grain, it is filling.
E: packaging, obtain from thicken pearl toner I, toner II, toner III ..., toner X.
Table 1
Table 2
Comparative example
According to the content (%) of each component of comparative example in the following table 3, and it is prepared according to the step identical as embodiment Toner XI, toner XII, toner XIII ..., toner XVII.
Table 3
Experimental effect analysis
Pigment experiment
After Melan- α cell after tested sample treatment, melanin production situation analysis is carried out.Logarithmic growth phase will be in Melan- α cell, adjustment density be 3 × 104It is inoculated in after a/mL in 9 orifice plates, every hole 2mL, at 37 DEG C and 5%CO2Under incubate It educates for 24 hours.Abandon culture solution after, the toner III of extraction embodiment 3, the toner V of embodiment 5, embodiment 7 toner VII, The toner VIII of embodiment 8, the toner XII of comparative example 2, the toner XVII of comparative example 7 and 30 μ g/mL placebo substances Each 3mL continues to be incubated for 72h, removes supernatant, after cleaning 2 times with PBS, is added and digests through 0.2% hole trypsase 1mL/, add Enter 1mL culture solution and stop digestion, cell suspension is made.
Cell is collected into centrifuge tube, supernatant is removed in centrifugation, and 100 μ L concentration of addition are 1mol/L NaOH, 37 DEG C of water-baths 1.5h, lytic cell and dissolution melanin granule.The dilution of 300 μ L distilled waters is added, 100 holes μ L/ is taken to add to 96 orifice plates after mixing, Every group sets 3 in parallel, and the melanin absorbance dissolved in 490nm wavelength measurement 1mol/L NaOH is converted into various total proteins It is as shown in table 4 below that each component melanin inhibiting rate is calculated in quality.
Inhibiting rate of each toner of table 4. to melanin production
(n=3, p < 0.01)
By 4 test result of table it is found that comparing with negative control group, toner III, toner V, toner VII are found There is apparent inhibiting effect to melanin production with toner VIII, inhibiting rate is respectively 55.3%, 62.1%, 54% and 82.4%, and inhibitory effect is substantially better than or suitable with placebo；Simultaneously also superior to comparative example toner XII, toner XVII The generation inhibiting rate of melanin be respectively 51.7%, 22.2%.
Moisture content of skin test
25 tested volunteers are randomly selected, wherein male 12, women 13.Subject elder generation wash hands forearm, Sit quietly 30min under constant wet temp (25 DEG C, RH43%) environment, then using subject's left and right arm two sides subregion as pair According to each region is 3cm × 3cm, smears the sample of phase homogenous quantities 30mg to fully absorbing, with Corneometer CM825 instrument Device tests the moisture content (Corneometer Unit, C.U.) of corresponding Test sites, and experimental data is repeated 8 times respectively, is obtained The average value tested every time is calculated 25 volunteers and contains in different time intervals point 0h, 2h, 4h, 6h mean skin moisture Amount is as shown in table 5, the toner I of comparing embodiment 1, the toner II of embodiment 2, the toner III of embodiment 3, comparative example 1 Toner XI, comparative example 6 toner XVI and blank district skin moisture content size.
The skin moisture content data summarization of table 5. different time, 25 subjects
In table 5, conspicuousness: "+" indicates significant difference (p < 0.05)；"-" indicates non-limiting difference (p > 0.05).
From the data in table 5, it can be seen that compared with blank district, comparative example 1 and 6, the toner I of the embodiment of the present invention, makeup Water II and toner III is considerably higher using the skin moisture content in 6h, namely has preferably moisturizing immediately and long-acting Moistening effect.
Inhibit propionibacterium acnes growth
By 5 × 105A/100 μ l of mL propionibacterium acnes (ATCC11827) suspension is coated in agar plate, each to cultivate Toner IV, the toner VII of embodiment 7, reality of toner I of the ware respectively containing 10% final concentration embodiment 1, embodiment 4 Apply the toner XVII of the toner VIII of example 8, the toner IX of embodiment 9 and comparative example 7.Each test sample 3 parallel. Plate is cultivated in 37 DEG C of oxygen-free environments.Observe the 2nd day and the 4th day each plate in bacterium colony growing state it is as shown in table 6.
Influence of 6. toner of table to propionibacterium acnes growing state
In table 6: "-" indicates sterile length of being born；"+" indicates a small number of bacterium colony growths；" ++ " indicates many bacterium colony growths；"++ + " indicate that bacterium colony dense growth is vigorous.
As shown in Table 6, the toner I, toner IV, toner VIII and toner IX of embodiment are to propionibacterium acnes Growth play good inhibiting effect, the toner XVII of the obvious comparative example 7 of inhibitory effect；The toner VII of embodiment 7 In, the skin conditioning agent used has certain inhibiting effect to propionibacterium acnes in the short time for kojic acid；And comparative example 7 Growth effect very little of the toner XVII to propionibacterium acnes.
4, physicochemical property test and analysis
To the toner I of embodiment 1, the toner IV of embodiment 4, embodiment 10 toner X, comparative example 1 makeup The makeup of water XI, the toner XIII of comparative example 3, the toner XIV of comparative example 4, the toner XV of comparative example 5 and comparative example 7 The physicochemical property of water XVII is tested and analysis, to its viscosity (BROOKFIELD brand HBDV-II+Pro viscosity in different time periods Meter, 25 DEG C, 3#, 20rpm), dilution 10 times under pH value and transparency investigated, the results are shown in Table 7.
The test of 7. physicochemical property of table and analysis
In table 7, (-) is indicated: viscosity is≤500mPa.S, and mobility is very good, and pearl does not stick wall；(+) indicates: viscosity For 500-1000mPa.S, good fluidity, a small number of pearls stick wall；(++) indicates: viscosity is 1000-3000mPa.S mobility one As, most of pearl sticks wall；(+++) indicates: viscosity 3000-8000mPa.S, can be with mobility, the glutinous wall of pearl；(++++) Indicate: viscosity is >=8000mPa.S, and the jelly gel of flowability, Suspended Pearl is flowable in toner；(+++ ++) table Show: forming solid gel and do not flow, pearl is static to be suspended in gel.
By in table 7 to embodiment 1,4 and 10 and comparative example 1,3-5,7 toner physicochemical property and transparency investigation can Know, over time, the pH value of toner I, IV and X of embodiment 1,4 and 10 will appear slow rising, while have very Significantly slowly from thickening effect, and keep very high transparency.And comparative example 1 toner XI formula with embodiment 1,4 and 10 compare, and due to a lack of film forming agent, pearl soluble component is constantly dissolved out, to cause the increase of product sediment, appearance is impermeable It is bright, it is unable to reach and has from thickening effect.
The toner XIII of comparative example 3 is different because of the selection of macromolecule film former compared to the examples, and product appearance is not yet Together, do not have from thickening effect simultaneously, transparency is as time goes by because turbid phenomenon can occur for calcium ion dissolution.
For the toner XIV of comparative example 4 although the very high grade of transparency can be kept, pH value and viscosity are more stable, are a Common toner formula system cannot reach of the invention from thickening effect, while the water solubility of its whitening effect and pearl Active matter is weaker than the effect of the toner of embodiment 1,4 and 10.
The toner XV of comparative example 5 can keep the very high grade of transparency, because not adding acidity regulator, its pH value of toner XV It will not change with viscosity, the water-soluble active object and calcium ion of pearl can not dissolve out, and cannot reach of the invention and thicken certainly Effect, whitening effect are also weaker than the effect of the toner of embodiment 1,4 and 10.
By the viscosity and pH value and apparent condition data of the toner XVII of comparative example 7 it is found that its usage experience and effect Fruit can not show a candle to the toner in the embodiment of the present invention 1,4,10.
The above, the only specific embodiment of the disclosure, but the protection scope of the disclosure is not limited thereto, it is any Those familiar with the art can easily think of the change or the replacement in the technical scope that the disclosure discloses, and should all contain It covers within the protection scope of the disclosure.Therefore, the protection scope of the disclosure should be based on the protection scope of the described claims.

Claims (10)

1. a kind of from thickening pearl toner, which is characterized in that with described from the weight percent for thickening pearl toner total weight Than meter, including following components:
Film forming agent: 0.01-1.0%；
Pearl: 0.05-5%；
Polyalcohol: 3-20%；
Skin conditioning agent: 0.0001-0.005%；
Moisturizing additive: 0.01-3.0%；
Acidity regulator: 0.001-0.05%；
Water: 71-95%；Wherein,
The film forming agent includes the combination of one or more of carragheen, gellan gum and sodium alginate；The pearl is Pearl particles or pearl powder.
2. according to claim 1 from thickening pearl toner, which is characterized in that with described total from thickening pearl toner The weight percent meter of weight,
The additional amount of the film forming agent is 0.1-0.8%；
The additional amount of the pearl is 0.05-4%；
The additional amount of the polyalcohol is 5-18%；
The additional amount of the skin conditioning agent is 0.0003-0.005%；
The additional amount of the moisturizing additive is 0.05-2.8%；
The additional amount of the acidity regulator is 0.002-0.05%；
The additional amount of the water is 75-93%.
3. according to claim 2 from thickening pearl toner, which is characterized in that with described total from thickening pearl toner The weight percent meter of weight,
The additional amount of the film forming agent is 0.15-0.5%；
The additional amount of the pearl is 0.5-2.5%；
The additional amount of the polyalcohol is 8-15%；
The additional amount of the skin conditioning agent is 0.0008-0.005%；
The additional amount of the moisturizing additive is 0.1-2.5%；
The additional amount of the acidity regulator is 0.005-0.03%；
The additional amount of the water is 80-91%.
4. according to claim 1-3 from thickening pearl toner, which is characterized in that the polyalcohol includes 1, One or both of 3-propanediol, methyl propanediol, dipropylene glycol, 1,2- pentanediol, 1,3 butylene glycol, glycerol and hexylene glycol More than.
5. according to claim 4 from thickening pearl toner, which is characterized in that the polyalcohol includes methyl-prop two The combination of one or more of alcohol, dipropylene glycol, 1,2- pentanediol and 1,3 butylene glycol.
6. according to claim 1-3 from thickening pearl toner, which is characterized in that the skin conditioning agent packet Include the combination of one or both of quaternary ammonium salt -73, kojic acid.
7. according to claim 1-3 from thickening pearl toner, which is characterized in that the moisturizing additive packet Include the combination of one or more of trehalose, pulullan polysaccharide, maltitol, antierythrite, urea and glycine betaine.
8. according to claim 1-3 from thickening pearl toner, which is characterized in that the acidity regulator packet Include the combination of one or more of citric acid, lactic acid, succinic acid and sodium phytate.
9. according to claim 1-3 from thickening pearl toner, which is characterized in that the thickening pearl certainly The pH value of toner is between 4-6.
10. from the preparation method for thickening pearl toner described in a kind of -9 any one according to claim 1, which is characterized in that packet Include the step of mixing each component from thickening pearl toner.
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Publication number Priority date Publication date Assignee Title
CN101199471A (en) * 2007-12-28 2008-06-18 浙江长生鸟珍珠生物科技有限公司 Pearl whitening moisturizing astringent and process for preparing same
CN105434312A (en) * 2015-12-30 2016-03-30 天津嘉氏堂科技有限公司 Psidium guajava moisturizing toner
CN106726920A (en) * 2016-12-16 2017-05-31 广州市科能化妆品科研有限公司 A kind of moisturizing astringent and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101199471A (en) * 2007-12-28 2008-06-18 浙江长生鸟珍珠生物科技有限公司 Pearl whitening moisturizing astringent and process for preparing same
CN105434312A (en) * 2015-12-30 2016-03-30 天津嘉氏堂科技有限公司 Psidium guajava moisturizing toner
CN106726920A (en) * 2016-12-16 2017-05-31 广州市科能化妆品科研有限公司 A kind of moisturizing astringent and preparation method thereof

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