CN108498431B - Cosmetic composition and cosmetic composition containing algae - Google Patents
Cosmetic composition and cosmetic composition containing algae Download PDFInfo
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- CN108498431B CN108498431B CN201810676708.7A CN201810676708A CN108498431B CN 108498431 B CN108498431 B CN 108498431B CN 201810676708 A CN201810676708 A CN 201810676708A CN 108498431 B CN108498431 B CN 108498431B
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- extract
- moisturizing
- cosmetic composition
- algae
- skin
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
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- 235000013619 trace mineral Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a cosmetic composition containing algae. The composition comprises 0.003-0.125% of algae mixture, 0.001-0.050% of radix Ophiopogonis extract, 0.100-25.000% of betaine and the balance of deionized water according to the mass percentage of the composition; wherein the algae mixture is composed of porphyridium extract, fucus extract, and Chondrus crispus extract. The content of the porphyridium extract is 0.001-0.005%, the content of the fucus extract is 0.001-0.030%, and the content of the Chondrus crispus extract is 0.001-0.090%. Also disclosed is a cosmetic composition using the cosmetic composition. The cosmetic composition containing algae has the effects of being natural, efficient, easy to be absorbed by human bodies, long in moisturizing time and the like, and is suitable for manufacturing various moisturizing cosmetic skin care products.
Description
Technical Field
The invention belongs to the technical field of daily chemical industry, and particularly relates to a cosmetic composition and a cosmetic composition containing algae.
Background
The moisture retention is the most basic and important requirement of cosmetics, as long as the skin care products are skin care products, the moisture retention cannot be avoided, other functions such as whitening, wrinkle resistance, oxidation resistance and the like are further summed and developed on the basis, and even oil control cosmetics cannot be kept moisture due to the fact that a large amount of moisture is consumed by skin oil metabolism.
The skin has the functions of barrier protection, hydration, moisture retention, sensory stimulation, body temperature regulation, secretion and excretion, absorption and metabolism and the like, and the skin which is most closely involved in the cosmetic is the epidermis, particularly the horny layer, and the horny cells are sandwiched by lipid to form a unique sandwich-like structure through the observation of a submicron structure. The stratum corneum acts like a "brick wall", the keratinocytes are "bricks", and the intercellular lipids are "mud" that acts as an adhesive, tightly linking the keratinocytes, normalizing the skin barrier, and really maintaining the skin. Intercellular lipids generally contain 40% ceramide, 25% cholesterol, 25% free fatty acids, and others. The stratum corneum contains some metabolites which form natural moisturizing factors, namely 40% of amino acid, 12% of lactate, 12% of pyrrolidone carboxylic acid, 7% of urea and the like; sebum is secreted by sebaceous glands, and can form milky sebaceous membrane after being mixed with sweat on the surface of skin, so that the sebum can maintain the healthy and micro-ecology of the skin and inhibit the growth and reproduction of bacteria and fungi besides softening the skin, and the sebum comprises the following components: 57.5% of triglyceride, 26% of wax, 12% of squalene and the like.
Traditional moisturizing method generally comprises adding ceramide, cholesterol, free fatty acid, other oil and fat, glycerol, butanediol, amino acid, lactic acid, urea, etc. from the aspects of intercellular lipid, natural moisturizing factor, etc. Intercellular lipid is oil-soluble, and is difficult to be added into some water-based transparent products such as moisturizing water, moisturizing essence and the like. Amino acid, lactic acid, urea and the like belong to micromolecule humectants which are easy to lose and cannot achieve long-acting moisture preservation. Glycerin, sorbitol, butanediol and the like lock and retain water through high-amount hydroxyl groups in molecular formulas, and can be influenced by the environmental humidity and play a positive role in a humid environment; in a very dry environment, the effect is relatively negative.
In recent years, complex carbohydrates have gained increased attention because they are less dependent on air humidity. Algae contains abundant saccharides, is natural and efficient, is easy to be absorbed by skin, is more and more accepted by consumers, has the validity of marine plant components on human skin accepted by world authorities, and is widely applied to the field of cosmetics. Currently, the most widely used non-algal genus is the genus morus in marine plant compositions. The algae grows in seawater medium with high salt, high pressure, low temperature, low nutrition, no illumination and extremely complex chemical components, the ecological environment, metabolites and metabolic characteristics of the algae are greatly different from those of land plants, and the algae are concentrated in that the algae contain biological active substances and metabolites with special structures in organisms. The algae contains abundant carbohydrates, proteins, lipids, trace elements, minerals, vitamins and the like, and the active matters can be applied to novel functional cosmetics and have wide market prospects.
Disclosure of Invention
The first object of the present invention is to provide a cosmetic composition containing algae according to the disadvantages of the prior art.
A second object of the present invention is to provide a cosmetic composition using the cosmetic composition containing algae.
In order to achieve the first purpose, the invention adopts the following technical scheme:
the cosmetic composition containing algae comprises, by mass, 0.003-0.125% of an algae mixture, 0.001-0.050% of an ophiopogon root extract, 0.100-25.000% of betaine and the balance deionized water; wherein the algae mixture is composed of porphyridium extract, fucus extract, and Chondrus crispus extract.
The content of the porphyridium extract is 0.001-0.005%, the content of the fucus extract is 0.001-0.030%, and the content of the Chondrus crispus extract is 0.001-0.090%.
Preferably, the content of the porphyridium extract is 0.002-0.004%, the content of the fucus extract is 0.005-0.020%, and the content of the Chondrus crispus extract is 0.020-0.060%.
Preferably, the content of the radix ophiopogonis extract is 0.005-0.015%.
Preferably, the content of betaine is 0.500-15.000%.
In order to achieve the second purpose, the invention adopts the following technical scheme:
a cosmetic composition comprising the alga-containing cosmetic composition.
Preferably, the cosmetic composition is moisturizing cleansing gel, moisturizing water, moisturizing essence liquid, moisturizing essence gel, moisturizing milk, moisturizing cream, moisturizing jelly film or moisturizing eye cream.
The cosmetic composition containing algae has the effects of being natural, efficient, easy to be absorbed by human bodies, long in moisturizing time and the like, and is suitable for manufacturing various moisturizing cosmetic skin care products.
Detailed Description
The composition for the cosmetics containing the algae comprises, by mass, 0.003-0.125% of an algae mixture, 0.001-0.050% of an ophiopogon root extract, 0.100-25.000% of betaine and the balance deionized water; wherein the algae mixture is composed of porphyridium extract, fucus extract, and Chondrus crispus extract.
The porphyridium extract is derived from porphyridium. The porphyridium is fresh water algae of porphyridium. The single cells are gathered together irregularly, and are coated with a layer of thin film to form red or light brown slices on wet soil and walls; when dry, it is in the form of a peel. Most cells are spherical, bloodred or dark purplish red, with 1 axicon-star or irregularly shaped chromosome and 1 unsheathed protein nucleus. Asexual reproduction with cell division. Cell diameters of 5-24 μm are widely distributed around the world. Porphyridium, a relatively primitive unicellular alga of the rhodophyta phylum, is capable of producing many bioactive substances, such as phycobiliproteins, polyunsaturated fatty acids and exopolysaccharide substances. The protein of the porphyridium accounts for about 50 percent of the biomass, wherein 84 percent of the protein is phycobiliprotein, and particularly, the B-phycobiliprotein has stable property. The porphyridium cell can accumulate 20% -50% biomass polysaccharide, the polysaccharide is a polymer formed by monosaccharides such as xylose, glucose and galactose, and the polysaccharide has unique colloid performance and high viscosity, and has a structure similar to algin and brown algae starch. Also contains polyunsaturated fatty acid, which accounts for about 9.5% of biomass, wherein more than 50% of the fatty acid is unsaturated fatty acid. Porphyridium, although it also contains EPA and phycoerythrin, most notably its polysaccharides. The porphyridium polysaccharide has the advantages of high intracellular and extracellular contents, high molecular weight, sulfonation and the like, and has the characteristics of mechanical support, biological recognition, ion exchange performance, cell protection function (drying resistance, stability to temperature, pH and salinity, environmental stress resistance, free radical oxidation resistance) and the like for the porphyridium polysaccharide. The porphyridium extract used in the invention contains abundant polysaccharide, the porphyridium polysaccharide can form a very uniform coating when being coated on the surface of the skin, is superior to polysaccharide such as hyaluronic acid and the like, slows down evaporation through moisture absorption capacity so as to keep moisture in the skin, and rebuilds an epidermal barrier. In the present invention, the amount of the porphyridium extract used is 0.001 to 0.005%, preferably 0.002 to 0.004%. The porphyridium extract used in the invention can be a porphyridium extract product manufactured by Soliance of France and is purchased from Oxue chemical Co., Ltd.
The Fucus vesiculosus extract is derived from Fucus vesiculosus, which is a brown algae attached to the rock on the bank and can be harvested when the tide is drawn. Its algal body is black brown, bifurcate branch, and is a flat angular leaf. The sea oak contains glutamic acid, the glutamic acid with the moisturizing characteristic can increase the softness and smoothness of the skin, and the sea oak has the miraculous effect of relieving sunburn and deeply replenishing water, so that the skin is soft and elastic; tighten the skin. In the present invention, the amount of the fucus extract used is 0.001 to 0.030%, preferably 0.005 to 0.020%. The Fucus vesiculosus extract used in the present invention may be a Fucus vesiculosus extract product manufactured by Lessonia, France, and is commercially available from Shanghai Boxue industries, Inc.
The Chondrus Crispus extract is derived from a seaweed named Chondrus Crispus, which is usually grown in rocks on the coast of the Atlantic ocean and is a relatively small red algae, containing a large amount of carrageenan, which is a sulfated vinegar of polysaccharides having the following structural formula:
wherein R represents polysaccharide, and can form film on skin surface to prevent water evaporation in skin. In the present invention, the amount of the Chondrus crispus extract used is 0.001 to 0.090%, preferably 0.020 to 0.060%. The Chondrus crispus extract used in the present invention may be obtained from the Chondrus crispus extract product manufactured by BASF corporation, available from vast Sen trade company, Guangzhou.
The radix ophiopogonis extract is rich in purified ophiopogon fructan, can promote skin moisturizing by improving the level of Natural Moisturizing Factor (NMF), is an active ingredient for repairing and moisturizing, and is a real stratum corneum biological humectant; in addition, the extract of the root of ophiopogon japonicus is capable of stimulating the natural synthesis of lipids and optimizing its tissues, maintaining an effective epidermal barrier, normalizing the barrier function of the skin, and having a positive effect on the formation of tight junctions and on the differentiation of keratinocytes; in addition, the ophiopogon root extract can maintain the moisture balance of the skin through three biological mechanisms of optimizing lipid tissues, strengthening epidermal connection and activating keratinocyte differentiation, and establish a water circulation mechanism for the skin so as to keep the skin moist and moist. In the present invention, the preferable amount of the radix Ophiopogonis extract is 0.005-0.015%. The radix Ophiopogonis extract used in the present invention may be obtained from the Liriope Tuber extract product manufactured by Silab, Inc., and purchased from Bilong, Inc., Guangzhou.
The betaine is a component of Natural Moisturizing Factor (NMF), and can improve the integrity of tight junction of keratinocytes, enhance skin barrier cohesion, and prevent dehydration of keratinocytes due to external stress. In addition, the betaine can improve the moisture content of skin, improve the expression of aquaporin AQP3, inhibit the activity of hyaluronidase, fix water and protect a screen, reduce the loss of skin moisture and capture surface water molecules. In the present invention, betaine is preferably used in an amount of 0.500 to 15.000%. The betaine used in the present invention can be a betaine product manufactured by DUPONT company and purchased from Guangzhou tide chemical technology Co.
Examples
The following percentages (%) are mass percentages based on the dry weight of the extract.
| Serial number | Composition (I) | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 |
| 1 | Deionized water | TO100 | TO100 | TO100 | TO100 | TO100 |
| 2 | Porphyridium extract | 0.001 | 0.002 | 0.003 | 0.004 | 0.005 |
| 3 | Fucus vesiculosus extract | 0.001 | 0.005 | 0.015 | 0.020 | 0.030 |
| 4 | Chondrus crispus extract | 0.001 | 0.020 | 0.050 | 0.060 | 0.090 |
| 5 | Radix Ophiopogonis extract | 0.001 | 0.005 | 0.010 | 0.015 | 0.050 |
| 6 | Betaine | 0.1 | 0.5 | 10.0 | 15.0 | 25.0 |
| 7 | Preservative | Proper amount of | Proper amount of | Proper amount of | Proper amount of | Proper amount of |
The specific steps for preparing the algae-containing composition according to the amounts of the substances in the above examples are as follows:
stirring and heating deionized water to 80-85 ℃, cooling to 45 ℃, adding porphyridium extract, fucus extract, carrageen crispus extract, ophiopogon root extract, betaine and preservative, controlling the rotating speed at 60 revolutions per minute, and stirring for 20 minutes to be completely uniform to obtain the composition for the cosmetics containing algae.
The cosmetic composition containing algae is suitable for being used as a raw material to manufacture various moisturizing cosmetic skin care products, including but not limited to moisturizing cleansing gel, moisturizing water, moisturizing essence gel, moisturizing milk, moisturizing cream, moisturizing gel film and moisturizing eye cream.
Application examples
The moisturizing essence gel prepared from the cosmetic composition containing algae has the following formula (the following percentages are in percentage by mass):
wherein: SEPINOV EMT10 and LANOL 99 are both manufactured by sibirak corporation and are commercially available from behabo corporation.
The specific steps for preparing the algae-containing composition moisturizing essence according to the dosage of each substance in the formula are as follows:
sterile deionized water was added to the main kettle and SEPINOV EMT10 was added gradually with mechanical stirring until it was gel-viscous. Adding LANOL 99, stirring, adding the composition, adding essence and antiseptic, stirring for 30min, inspecting, and discharging.
To demonstrate the long-lasting moisturizing efficacy of the composition, the present invention performed the following moisturizing effect tests:
algae moisturizing essence gels were prepared as experimental preparations according to the formulations of application examples 1 to 5, and designated as sample 1, sample 2, sample 3, sample 4, and sample 5, respectively; in addition, a moisturizing essence gel not containing the composition of the present invention was prepared as an experimental preparation and named as a control. The specific method comprises the following steps:
6 groups of subjects, women aged 23-35 years, were selected as trial subjects. The test subject takes a rest for 30min in a constant temperature and humidity (temperature (22 +/-1) DEG C and humidity (50 +/-10)%) environment, selects a proper sample application area, measures initial data during T0 (before using a product), applies samples to the selected area on the double front arms according to a random table, applies a single application according to the dosage of (2.0 +/-0.1) mg/cm2 test samples, performs the whole test process in the constant temperature and humidity environment, and performs noninvasive instrument measurement on the tested part after applying the product for T30min, T60min, T120min and T240min, measures the hydration content of the stratum corneum, and the percutaneous water loss rate and records.
1. Measurement of the skin stratum corneum hydration Content (CAP) was performed using a MOISTURETERSC MSC1212 (DELFIN). OISTRURETERSC MOISTURETERSC is used clinically to measure the hydration water content of the horny layer of the arm skin. Higher values indicate higher hydration of the stratum corneum, indicating better moisturizing effect of the product.
2. Measurement of skin transepidermal water loss analysis (TEWL) the device used was TAPOETERSWL5167 (DELFIN). The TAPOMETER is used clinically to measure the percutaneous water loss rate of the arm. A smaller value indicates a better skin barrier, indicating a better water-locking effect of the product.
Table 1: stratum corneum hydration level of skin
Table 2: rate of percutaneous water loss
In a preferred embodiment, the stratum corneum hydration level of the skin is significantly increased and the transepidermal water loss is significantly reduced compared to baseline (T0) at T30min, T60min, T120min, T240min after sample application relative to blank treated skin; compared with the skin treated by the control group, the hydration content of the horny layer of the skin is also obviously increased, and the water loss in the skin is also obviously reduced. The present invention also provides increased moisturization and other benefits to the skin for relatively longer periods of time, e.g., up to 8, 12, and 24 hours, with no discomfort perceived.
The results demonstrate that the preferred embodiments of the present invention represented by application examples 1-5 provide excellent skin moisturizing properties, with significant improvement in skin moisturizing effect after 30 minutes and 1 hour, far better than the results of the control and blank samples. This result suggests that the present compositions provide a surprising and unexpected synergistic moisturizing effect.
Claims (3)
1. The cosmetic composition containing algae is characterized by comprising 0.002-0.004% of porphyridium extract, 0.005-0.020% of fucus extract, 0.020-0.060% of carrageen crispus extract, 0.005-0.015% of radix ophiopogonis extract, 0.500-15.000% of betaine and the balance of deionized water in percentage by mass of the composition.
2. A cosmetic composition comprising the alga-containing cosmetic composition according to claim 1.
3. The cosmetic composition according to claim 2, wherein the cosmetic composition is a moisturizing cleansing gel, or a moisturizing lotion, or a moisturizing essence liquid, or a moisturizing essence gel, or a moisturizing emulsion, or a moisturizing cream, or a moisturizing gel film, or a moisturizing eye cream.
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