CN106074304B - The anti-aging cosmetics composition with smooth out wrinkles, even skin a kind of of microballoon containing Sodium Hyaluronate and peptide - Google Patents
The anti-aging cosmetics composition with smooth out wrinkles, even skin a kind of of microballoon containing Sodium Hyaluronate and peptide Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The invention discloses a kind of microballoon containing Sodium Hyaluronate and the anti-aging cosmetics compositions with smooth out wrinkles, even skin of peptide, be made of the raw material of following mass percentage: Sodium Hyaluronate microballoon 0.5~3.0%, palmityl tripeptides 0.5~3.0%, Radix Ophiopogonis root extract 0.5~5.0%, Sodium Hyaluronate moisturizing compound 0.5~5.0%, surplus are one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.The active component of the cosmetic composition includes Sodium Hyaluronate microballoon, palmityl tripeptides, Radix Ophiopogonis root extract, Sodium Hyaluronate moisturizing compound.Using various composition reasonable combination, cooperate with shared, is increasing skin moisture content, improving dry skin, rebuilding on the basis of skin barrier, the senile-resistant efficacy of smooth out wrinkles, even skin is reached by the addition of Sodium Hyaluronate microballoon, small-molecule peptide.
Description
Technical field
The invention belongs to cosmetic composition technical fields, and in particular to a kind of microballoon containing Sodium Hyaluronate and peptide have
The anti-aging cosmetics composition of smooth out wrinkles, even skin effect.
Background technique
With the growth at age, the natural aging that skin is influenced by endogenous factor shows as cutis laxa, occurs tiny
Wrinkle, while having dry skin, the increase of furfur, brittleness, repair function decline.Water is important molded article, cuticula in cuticula
Middle moisture content is about 10%~15%, and the relative constant of water depends on natural moisturizing factor, including amino acid, pyrrolidines
Ketone hydroxy acid, lactate, urea, urea acid, creatine, phosphate etc..Increase with the age, natural moisturizing factor content in keratoderma
It reduces, declines skin hydration ability, only the 75% of normal skin.Wrinkle of skin increases, and the surface area of skin increases, moisture
It loses and increases, therefore natural aging first appears as dry skin.
With advancing age, the ability decline of internal cell synthesis hyaluronic acid (HA).HA is skin epidermis, corium group
One of main component knitted accounts for about 70% of acid mucopolysaccharide contained by skin.HA is in conjunction with protein in skin, with compound
Form is present in iuntercellular, forms gel and cell sticks together.It has the critical function for adjusting moisture of skin, has skin
There are certain toughness and elasticity.HA content declines in human body, and skin histology thickness reduces, and skin elasticity reduces, degree of roughness
Increase, wrinkle occurs in skin.Wrinkle can be the fine wrinkle and deep wrinkle of epidermis, i.e., small wrinkle and big wrinkle, small wrinkle be by
It is lost in moisture of skin, collagenous fibres and elastic fibers are reduced so that caused by cutis laxa, and big wrinkle is then in cutis laxa
On the basis of, because the muscle under skin shrinks for a long time and cannot alleviate formation.
The approach of anti-aging cosmetics anti-aging currently on the market is concentrated mainly on three big aspects: (1) removing
The active oxygen radical of amount；(2) promote cell metabolism；(3) elastin laminin of the collagen in skin is supplemented.Although this
Three big approach can solve most of problem of ageing skin, but increase skin moisture content, improve dry skin, rebuild skin
Barrier is smooth out wrinkles, even skin most efficiently approach.
Cause skin aging the reason is that reasons various and that these are numerous often play solely the aging of skin
From effect, i.e., each reason can cause the aging of skin.So to comprehensively consider skin when developing anti-aging product
The reason of aging, acts on simultaneously from multipath, can be only achieved more preferably anti-aging effects.But it is anti-ageing to take multipath effect
Always, it is necessary to while considering safety, otherwise serious injury can be generated to skin, be not only unable to anti-aging in this way, accelerate instead
The aging of skin.
Summary of the invention
There are smooth out wrinkles, even skin function the purpose of the present invention is to provide a kind of microballoon containing Sodium Hyaluronate and peptide
The anti-aging cosmetics composition of effect, the active component of the cosmetic composition include Sodium Hyaluronate microballoon, small-molecule peptide,
Natural botanical extraction liquid and moisturizing compound are increasing skin moisture content using various composition reasonable combination, cooperate with shared,
Improve dry skin, rebuilds on the basis of skin barrier, reached by the addition of Sodium Hyaluronate microballoon, small-molecule peptide and smoothed
The senile-resistant efficacy of wrinkle, even skin.
Above-mentioned purpose of the invention is achieved through the following technical solutions: a kind of microballoon containing Sodium Hyaluronate and peptide
Have effects that the anti-aging cosmetics composition of smooth out wrinkles, even skin, be made of the raw material of following mass percentage:
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
The active component of anti-aging cosmetics composition in the present invention include Sodium Hyaluronate microballoon, palmityl tripeptides,
Radix Ophiopogonis root extract and Sodium Hyaluronate moisturizing compound.
The present invention selects natural botanical extraction liquid and moisturizing compound first to reach increase skin moisture content, improves skin
Dry, the effect of rebuilding skin barrier, reselection Sodium Hyaluronate microballoon, small-molecule peptide reach smooth out wrinkles, even skin
Senile-resistant efficacy, the mode of this combination and cooperation is to reach safe and effective anti-aging effects, is had very important significance.
As a preferred technical solution of the invention, the anti-aging cosmetics composition in the present invention is by following quality
The raw material of percentage composition is made:
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
As a kind of more preferably technical solution of the invention, the anti-aging cosmetics composition in the present invention is by following quality
The raw material of percentage composition is made:
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
In above-mentioned anti-aging cosmetics composition:
The Sodium Hyaluronate microballoon is commercial product, and the Sodium Hyaluronate and molecule of 40kDa are preferably less than by molecular weight
Konjac polysaccharide crosslinking dehydration of the amount higher than 200kDa is formed.
Principle with hygroscopic effect bead is: bead is dehydrated first, water-filling expands after the bead of dehydration enters skin,
In water filling process, the volume of bead increases, and has very strong moisture holding capacity.Skin changes within a short period of time, deep layer
Wrinkle becomes less obvious.The improvement that can find deep skin time is used for a long time, apparent variation is relative to profound improvement
Much faster.
Sodium Hyaluronate microballoon in the present invention is also the microballoon with hygroscopic effect, and the microballoon is by two kinds of biopolymers
Composition: the crosslinking dehydration of the konjac polysaccharide (> 200kDa) of low molecular weight sodium hyaluronate (< 40kDa) and high molecular weight is formed.Thoroughly
The effect of bright matter acid sodium is to skin is it is well known that selecting low molecular weight sodium hyaluronate is because its water imbibition is more preferable.Konjac polysaccharide
It is a kind of plant polyose, wettability power is brilliant, can absorb the moisture of 200 times of its own weight.Amorphophallus aroid, from
It is so grown on the forest of Thailand, Vietnam and southern china, wettability power is strong.The microballoon that dehydrated crosslinking is formed can penetrate into
Epidermis upper layer absorbs the moisture being evaporated from skin deep layer.Due to its water absorption character, microsphere volume is increased rapidly, after expansion
It enables that skin is more compact, smooth out wrinkles, enables skin surface more smooth, can more increase elasticity of skin, and long-acting moisturizing can be possessed
Effect.Therefore, Sodium Hyaluronate microballoon can quick smooth out wrinkles, so that skin surface is become smooth, long-time service can improve wrinkle,
Long-acting moisturizing.
As a preferred embodiment of the present invention, palmityl tripeptides of the present invention are the sweet of palmityl tripeptides
Oil solution.
200~300mg of palmityl tripeptides is preferably comprised in every L glycerol aqueous solution.
It is the glycerine water solution of palmitic acid acyl tripeptides herein in regard to palmityl tripeptides, only palmityl tripeptides one of which is applied
It enumerates, is not restriction.
Palmityl tripeptides are commercial product, are the native peptides Pal- based on a kind of titanium dioxide from synthesis, purification
KMO2K, sequence are palmityl-lysyl-dioxy methionyl-lysine (Palmitoyl-Lysyl-Dioxymethionyl-
Lysine)。Pal-KMO2K can promote the synthesis of extracellular matrix macromolecular, therefore it shows the work such as matrikines
Property." Matrikines " is one section and is less than or equal to 20 amino acid sequences, is dermal matrix before not yet healing after skin is hurt
Hydrolysate.Collagen, elastin laminin and the hydrolysis of fibronectin bletilla fibrin generate soluble peptide, these are soluble
Peptide is autocrine and Paracrine courier, adjustable wound healing proteins expression.Matrikines contains pentapeptide KTTKS
(referred to as microcollagen derives from procollagen a1 chain hydrolysate), tripeptides GHK (come from I-type collagen a2 chain water
Solve product) and other various peptide fragments from elastin laminin and Kallinin.Matrikines can be to connective tissue
It rebuilds and proliferation process carries out feedback regulation, can be generated during skin repair largely more than under the normal physiological period
Skin repair albumen.So Pal-KMO2K can promote 6 kinds of elements in skin matrix and epidermis and corium articulamentum (DEJ)
Synthesis, this 6 kinds of elements be Type I collagen albumen, III collagen type, type Ⅳ collagen albumen, laminin, fibronectin
White, hyaluronic acid.Therefore wrinkles on one's forehead and crow's feet can be filled inside skin, enable skin smooth, full.
As a preferred embodiment of the present invention, the Radix Ophiopogonis root extract is commercial product, it is preferred that its
Solid content is preferably 90~130g/L, and the Radix Ophiopogonis levulan rich in purifying analyzes the molecular weight of its levulan from spectrum
Between 500 to 7500 dalton.
Radix Ophiopogonis root extract in the present invention, latin name are OPHIOPOGON JAPONICUS, from the stem tuber for being rich in Radix Ophiopogonis
Middle purifying.It originating from Asia, is widely used on traditional Chinese medicine, because the stem tuber of Radix Ophiopogonis contains mucopolysaccharide it has very
Good water lock performance.Activation epidermis lipid synthesis simultaneously optimizes its tissue, reinforces epidermis connection, and activation keratinocyte differentiation is
Three biological mechanisms of skin holding water balance.The spectral signature of extremely dry skin and normal can be determined using Raman spectrum
The main difference of skin is the institutional framework of epidermis lipid.Radix Ophiopogonis levulan contained by Radix Ophiopogonis root extract can increase Claudin-1
(forming transmembrane protein necessary to close connect) and Zonula Occludens-1 (zonuls occludens albumen -1) synthesis, form tight
It causes connection network and improves the level of cuticula NMF (natural moisturizing factor), improve the adhesive force on epidermis upper layer, to activate table
Skin lipid synthesis simultaneously optimizes its tissue, reinforces epidermis connection, recombinates the barrier function of skin.Claudin-1 (forms close connection
Necessary transmembrane protein) and Zonula Occludens-1 (zonuls occludens albumen -1) be main tight junction protein,
Cell tracking and barrier function balance aspect play an important role.Loricrin and silk polyprotein are cutin layer formation processes
In protein.Silk polyprotein be profilaggrin converted under the facilitation of enzyme and the protein that generates, it is in cutin
Keratin filament is aggregated into the lower part crude fibre of layer, therefore is a part of epidermis structure.Radix Ophiopogonis root extract is exactly to pass through
Activation silk polyprotein synthesis is to promote keratinocyte differentiation.Therefore, Radix Ophiopogonis root extract is by activating epidermis lipid synthesis simultaneously
Optimize its tissue, reinforces epidermis connection, and activation keratinocyte differentiation to promote skin moisturizing, rebuild skin barrier.
As a preferred embodiment of the present invention, Sodium Hyaluronate moisturizing compound of the present invention is commercially available
Product, preferred compound composition and ratio, the Sodium Hyaluronate moisturizing compound are made of the raw material of following mass percentage:
Sodium Hyaluronate 0.05~0.1%, glycerol 37~42%, water 31~38%, Anjidew NL50 5~11%, urea 5~11%, trehalose
1~4%, triacetyl glycerine 0.1~0.7%, polyquaternium -51 0.1~1%.
The chemical composition of human body is containing about the water for being more than 70%, so carrying out certain moisturizing to skin can be to maintenance skin
Health and beauty are extremely important.It is elastic, smooth and it is soft be all healthy skin important feature, major part depends primarily on
Water content in skin.The skin of dehydration can become dry and fragile, and the internal structure of skin will receive destruction.With the time
Loss, the reason of variation of environment and age can make the born moisturizing hypodynamia of skin, as a result lead to dry skin and shape
At microgroove and wrinkle.
Water holding ingredient polyquaternium -51 is the basic platform of the moisturizing compound, make other water lock ingredient Sodium Hyaluronates,
Urea, Anjidew NL50, carbohydrate, glycerol are attached on the skin.It, can also be in skin table other than it can promote the absorption and holding capacity to water
Face forms a tunic and helps to prevent the loss of moisture, and stablizes the skin texture of lamelliform.In addition the hyaluronic acid of high molecular weight
A kind of sodium --- addition of generally acknowledged effective moisturizing ingredient makes moisture-keeping efficacy as reach best as possible.Trehalose is as the moisturizing
Compound is strengthened, this polysaccharide can play the part of the role of " locking ", guarantee that all moisturizing ingredients are enclosed by polymer nature structure
System, and keep the connection with skin surface.Therefore, which is a 3 D stereo moisture-keeping system, and water absorbent surface is protected
Wet, surface filming moisturizing, deep layer repair moisturizing, form barrier in skin surface, firmly lock moisture.
The dosage form of cosmetic composition of the present invention is preferably a variety of systems that can be accepted such as cream shape or emulsion form
Dosage form formula.It can be prepared using the conventional method of this field.
The invention has the following advantages that present invention microballoon containing Sodium Hyaluronate and peptide has smooth out wrinkles, even skin
The anti-aging cosmetics composition of effect contain can quickly smooth out wrinkles, so that skin surface is become smooth filled-type ingredient transparent
Matter acid sodium microballoon can promote the anti-aging palm of the synthesis of 6 kinds of elements in skin matrix and epidermis and corium articulamentum (DEJ)
Acyl tripeptides, pass through activation epidermis lipid synthesis and optimize its tissue, reinforce epidermis connection and activation keratinocyte differentiation to
The Radix Ophiopogonis root extract for promoting skin moisturizing, rebuilding skin barrier, is repaired by water absorbent surface moisturizing, surface filming moisturizing, deep layer
Multiple moisturizing is to form barrier in skin surface, firmly lock the Sodium Hyaluronate moisturizing compound of moisture, four kinds of active constituents
Synergistic effect reaches the senile-resistant efficacy of smooth out wrinkles, even skin.
Detailed description of the invention
Fig. 1 is keratoderma water content test chart in embodiment 6；
Fig. 2 is that variation of the forehead expression line in 6 hours improves result figure in embodiment 6, wherein left figure be before use, in
Between figure be using after 1 hour, right figure is using after 6 hours；
Fig. 3 is that canthus fishtail line improves result figure in embodiment 6, and wherein left figure is before use, right figure is using rear.
Specific embodiment
The anti-ageing aging with smooth out wrinkles, even skin of microballoon containing Sodium Hyaluronate and peptide provided by the invention
Cosmetic compositions, which has the effect of quick smooth out wrinkles, smooth skin, long-acting anti-ageing, with hyaluronic acid
Sodium microballoon, palmityl tripeptides, Radix Ophiopogonis root extract, Sodium Hyaluronate moisturizing compound are chief active additive, and addition
Cosmetic often uses matrix components emulsifier, grease, moisturizer, thickener, preservative, essence, deionized water, purified water and distilled water
One or more of be made.
Embodiment 1
Comfort wrinkle cream:
Form the above-mentioned component and its mass percentage for comforting wrinkle cream are as follows:
Oily phase:
Water phase:
High temperature adds after emulsification:
Triethanolamine 0.10
Deionized water 1.80
Low temperature adds after emulsification:
After oily phase, water phase are heated separately to 80 DEG C, several minutes of two-phase mixtures homogeneous, it is 10% that mass percentage, which is added,
Triethanolamine aqueous solution, stir evenly, stirring cooling, cool to 45 DEG C of addition palmityl tripeptides, Radix Ophiopogonis root extract, transparent
Matter acid sodium moisturizing compound, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring are equal
It is even, at white fine and smooth uniform lotion after 35 DEG C of placements.
Sodium Hyaluronate microballoon is the UItra Filling Spheres of commercially available German BASF (BASF) company, this is micro-
Ball is that konjac polysaccharide (>200kDa) crosslinking dehydration of low molecular weight sodium hyaluronate (<40kDa) and high molecular weight is formed.
Palmityl tripeptides are the MATRIXYL synthe ' 6 of commercially available France Si Dama (SEDERMA) company.Palmityl tripeptides
For the glycerine water solution of palmityl tripeptides, palmityl tripeptides about 250mg is contained in every L glycerol aqueous solution.It is not limited to brown
The glycerine water solution of palmitic acid acyl tripeptides is only to enumerate herein, is not restriction.
Radix Ophiopogonis root extract is the COHESIUM of commercially available France Qian Laibo (SILAB) company, the solid of Radix Ophiopogonis root extract
Object content is preferably 90~130g/L, is herein only to enumerate, and is not restriction.
Sodium Hyaluronate moisturizing compound is the Advanced Moisture Complex of commercially available German BASF (BASF) company.
The mass percent containing Sodium Hyaluronate is 0.05~0.1% in Sodium Hyaluronate moisturizing compound, glycerol 37~
42%, water 31~38%, Anjidew NL50 5~11%, urea 5~11%, trehalose 1~4%, triacetyl glycerine 0.1~0.7%,
Polyquaternium -51 0.1~1% is only to enumerate herein, is not restriction.
Embodiment 2
Comfort wrinkle cream:
Form the above-mentioned component and its mass percentage for comforting wrinkle cream are as follows:
Oily phase:
Water phase:
High temperature adds after emulsification:
Triethanolamine 0.20
Deionized water 1.80
Low temperature adds after emulsification:
After oily phase, water phase are heated separately to 80 DEG C, several minutes of two-phase mixtures homogeneous, it is 10% that mass percentage, which is added,
Triethanolamine aqueous solution, stir evenly, stirring cooling, cool to 45 DEG C of addition palmityl tripeptides, Radix Ophiopogonis root extract, transparent
Matter acid sodium moisturizing compound, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring are equal
It is even, at white fine and smooth uniform lotion after 35 DEG C of placements.
The mass percent containing Sodium Hyaluronate is 0.05~0.1% in Sodium Hyaluronate moisturizing compound, glycerol 37~
42%, water 31~38%, Anjidew NL50 5~11%, urea 5~11%, trehalose 1~4%, triacetyl glycerine 0.1~0.7%,
Polyquaternium -51 0.1~1% is only to enumerate herein, is not restriction.
Sodium Hyaluronate microballoon, palmityl tripeptides, Radix Ophiopogonis root extract, the source of Sodium Hyaluronate moisturizing compound are same real
Apply example 1.
Embodiment 3
Comfort wrinkle frost:
Form the above-mentioned component and its mass percentage for comforting wrinkle frost are as follows:
Oily phase:
Water phase:
High temperature adds after emulsification:
Triethanolamine 0.20
Deionized water 1.80
Low temperature adds after emulsification:
After oily phase, water phase are heated separately to 80 DEG C, several minutes of two-phase mixtures homogeneous, it is 10% that mass percentage, which is added,
Triethanolamine aqueous solution, stir evenly, stirring cooling, cool to 45 DEG C of addition palmityl tripeptides, Radix Ophiopogonis root extract, transparent
Matter acid sodium moisturizing compound, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring are equal
It is even, at white fine and smooth uniform lotion after 35 DEG C of placements.
The mass percent containing Sodium Hyaluronate is 0.05~0.1% in Sodium Hyaluronate moisturizing compound, glycerol 37~
42%, water 31~38%, Anjidew NL50 5~11%, urea 5~11%, trehalose 1~4%, triacetyl glycerine 0.1~0.7%,
Polyquaternium -51 0.1~1% is only to enumerate herein, is not restriction.
Sodium Hyaluronate microballoon, palmityl tripeptides, Radix Ophiopogonis root extract, the source of Sodium Hyaluronate moisturizing compound are same real
Apply example 1.
Embodiment 4
Comfort wrinkle frost:
Form the above-mentioned component and its mass percentage for comforting wrinkle frost are as follows:
Oily phase:
Water phase:
High temperature adds after emulsification:
Triethanolamine 0.20
Deionized water 1.80
Low temperature adds after emulsification:
After oily phase, water phase are heated separately to 80 DEG C, several minutes of two-phase mixtures homogeneous, it is 10% that mass percentage, which is added,
Triethanolamine aqueous solution, stir evenly, stirring cooling, cool to 45 DEG C of addition palmityl tripeptides, Radix Ophiopogonis root extract, transparent
Matter acid sodium moisturizing compound, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring are equal
It is even, at white fine and smooth uniform lotion after 35 DEG C of placements.
Embodiment 5
Comfort wrinkle frost:
Form the above-mentioned component and its mass percentage for comforting wrinkle frost are as follows:
Oily phase:
Water phase:
High temperature adds after emulsification:
Triethanolamine 0.20
Deionized water 1.80
Low temperature adds after emulsification:
After oily phase, water phase are heated separately to 80 DEG C, several minutes of two-phase mixtures homogeneous, it is 10% that mass percentage, which is added,
Triethanolamine aqueous solution, stir evenly, stirring cooling, cool to 45 DEG C of addition palmityl tripeptides, Radix Ophiopogonis root extract, transparent
Matter acid sodium moisturizing compound, preservative (preservative commonly used in the art), essence (essence commonly used in the art), stirring are equal
It is even, at white fine and smooth uniform lotion after 35 DEG C of placements.
Wherein the mass percent containing Sodium Hyaluronate is 0.05~0.1% in Sodium Hyaluronate moisturizing compound, glycerol
37~42%, water 31~38%, Anjidew NL50 5~11%, urea 5~11%, trehalose 1~4%, triacetyl glycerine 0.1~
0.7%, polyquaternium -51 0.1~1% is only to enumerate herein, is not restriction.
Sodium Hyaluronate microballoon, palmityl tripeptides, Radix Ophiopogonis root extract, the source of Sodium Hyaluronate moisturizing compound are same real
Apply example 1.
Embodiment 6
Observation on probation
Cosmetics and control sample progress observation of curative effect are comforted using prepared by the present invention
Sample: embodiment 5
Control sample: by Sodium Hyaluronate microballoon, palmityl tripeptides, the Radix Ophiopogonis root extract, Sodium Hyaluronate in embodiment 5
Moisturizing compound removes
1, moisture retention is tested:
30 people of volunteer, respectively in 4 × 4cm of right-hand man's inner forearm label2Test area, same arm while label 2
A region, it is interregional every 2cm.The measurement of tested region and control zone is carried out using moisture of skin tester, each region is flat
Row measurement 3 times.The blank value of each test zone is first measured, 2.0 ± 0.1mg sample/cm is then pressed2Dosage, referred to using latex
Sample is spread evenly across in trial zone by set.Smearing measures tested region respectively in 28 days and the skin in blank control region is aqueous
Amount.
Human detection result shows: using cosmetics of the present invention with after control sample 4 weeks, the test of keratoderma water content is tied
Fruit shows that cosmetics of the present invention and control sample comparison skin basic water content improve 14.1%, specifically as shown in fig. 1.
2, skin elasticity measuring method:
30 people of volunteer, respectively in right-hand man's inner forearm label 4 × 4cm2 test area, same arm while label 2
A region, it is interregional every 2cm.Carry out the measurement of tested region and control zone using skin elasticity tester, each region according to
According to parallel determination 3 times.The blank value of each test zone is first measured, 2.0 ± 0.1mg sample/cm is then pressed2Dosage, use cream
Sample is spread evenly across in trial zone by rubber finger cot.After smearing 28 days, the skin bullet in tested region and blank control region is measured
Property.
Human detection result shows: after comforting wrinkle frost 28 days, the elasticity of skin has different degrees of raising, averagely mentions
It is high by 22%.
3, desalinate wrinkle effect
It comforts wrinkle frost to try out by 35 people 28 days, the age, 35 human faces had different degrees of microgroove, dry line from 35~50 years old
With wrinkle and blee it is more low and deep.
Application method: per applying 2 times beyond the highest heavens, usage amount is that face smearing is uniform.
Start to become to moisten using skin after 28 days, smoothly, restore gloss and elasticity, wherein 27 (77%) consumers senses
Feel that crow's feet has apparent desalination, 24 (68%) consumers feel that wrinkle has apparent desalination.
4, the variation effect to forehead expression line in 6 hours
Using in cosmetics of the present invention 6 hours, apparent desalination is had occurred in forehead expression line, the results showed that, 86% by
Examination person dry line, microgroove and expression line in using this cosmetics 6 hours have different degrees of desalination, and skin becomes obviously flat
It is sliding, it is specific as shown in Figure 2.
5, to crow's feet improvement
Improvement to crow's feet: after canthus uses cosmetics of the present invention (embodiment 5) 2 months, 83% subject's skin
Skin wrinkle depth shoals, and wrinkle is reduced, and result is as shown in figure 3, from figure 3, it can be seen that use of the invention cosmetics 2 months
Afterwards, wrinkle of skin depth shallower, deep wrinkles significantly reduce.
Meanwhile subject's skin of face visual observations, skin become ruddy full, microgroove be improved significantly.
It is any ripe although the present invention is disclosed as above with embodiment, its protection scope being not intended to limit the invention
Those skilled in the art are known, in made change and retouching without departing from the spirit and scope of the invention, should belong to this hair
Bright protection scope.
Claims (7)
1. the anti-aging cosmetics combination with smooth out wrinkles, even skin of a kind of microballoon containing Sodium Hyaluronate and peptide
Object, it is characterized in that being made of the raw material of following mass percentage:
Sodium Hyaluronate microballoon 0.5 ~ 3.0%
Palmityl tripeptides 0.5 ~ 3.0%
Radix Ophiopogonis root extract 0.5 ~ 5.0%
Sodium Hyaluronate moisturizing compound 0.5 ~ 5.0%
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation；
The Sodium Hyaluronate microballoon is commercial product, and the Sodium Hyaluronate and molecular weight by molecular weight less than 40kDa are higher than
The konjac polysaccharide crosslinking dehydration of 200kDa is formed.
2. microballoon containing Sodium Hyaluronate according to claim 1 and peptide have effects that smooth out wrinkles, even skin it is anti-
Aging cosmetic composition, it is characterized in that being made of the raw material of following mass percentage:
Sodium Hyaluronate microballoon 2.0 ~ 3.0%
Palmityl tripeptides 2.0 ~ 3.0%
Radix Ophiopogonis root extract 2.0 ~ 5.0%
Sodium Hyaluronate moisturizing compound 2.0 ~ 5.0%
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
3. microballoon containing Sodium Hyaluronate according to claim 1 and peptide have effects that smooth out wrinkles, even skin it is anti-
Aging cosmetic composition, it is characterized in that being made of the raw material of following mass percentage:
Sodium Hyaluronate microballoon 3.0%
Palmityl tripeptides 3.0%
Radix Ophiopogonis root extract 5.0%
Sodium Hyaluronate moisturizing compound 5.0%
Surplus is one or more of common matrix, deionized water, purified water and the distilled water of cosmetics exterior-applied formulation.
4. microballoon containing Sodium Hyaluronate according to claim 1-3 and peptide has smooth out wrinkles, even skin
The anti-aging cosmetics composition of effect, it is characterized in that: the palmityl tripeptides are the glycerine water solution of palmityl tripeptides.
5. microballoon containing Sodium Hyaluronate according to claim 1-3 and peptide has smooth out wrinkles, even skin
The anti-aging cosmetics composition of effect, it is characterized in that: the Radix Ophiopogonis root extract is commercial product.
6. microballoon containing Sodium Hyaluronate according to claim 1-3 and peptide has smooth out wrinkles, even skin
The anti-aging cosmetics composition of effect, it is characterized in that: the Sodium Hyaluronate moisturizing compound is commercial product.
7. microballoon containing Sodium Hyaluronate according to claim 1-3 and peptide has smooth out wrinkles, even skin
The anti-aging cosmetics composition of effect, it is characterized in that: the dosage form of the cosmetic composition is cream shape or emulsion form.
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| CN108498431B (en) * | 2018-06-27 | 2020-06-16 | 广州澳希亚实业有限公司 | Cosmetic composition and cosmetic composition containing algae |
| CN110251414A (en) * | 2019-07-19 | 2019-09-20 | 珠海海狮龙生物科技有限公司 | A kind of anti-wrinkle cream and preparation method thereof |
| CN111214418A (en) * | 2020-03-13 | 2020-06-02 | 佛山市奥姿美生物科技有限公司 | Efficient barrier repair composition and application thereof |
| CN111449986A (en) * | 2020-04-09 | 2020-07-28 | 广州市迪笙生物科技有限公司 | Compound anti-wrinkle-smoothing agent and preparation method thereof |
| CN111514055A (en) * | 2020-05-06 | 2020-08-11 | 深圳市健翔生物制药有限公司 | Cosmetic polypeptide composition granules with anti-inflammatory repair effect |
| CN111588644B (en) * | 2020-06-02 | 2022-08-30 | 浙江英树生物科技有限公司 | Moisturizing composition and preparation method and application thereof |
| CN112870092A (en) * | 2021-01-29 | 2021-06-01 | 广州集妍化妆品科技有限公司 | Two-phase essence and preparation method thereof |
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