CN110522671B - Deep water replenishing compound and preparation method thereof - Google Patents
Deep water replenishing compound and preparation method thereof Download PDFInfo
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- CN110522671B CN110522671B CN201910974714.5A CN201910974714A CN110522671B CN 110522671 B CN110522671 B CN 110522671B CN 201910974714 A CN201910974714 A CN 201910974714A CN 110522671 B CN110522671 B CN 110522671B
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- water replenishing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a deep water replenishing compound and a preparation method thereof, wherein the deep water replenishing compound comprises the following components in parts by weight: 0.05-1 part of hyaluronic acid, 0.04-2 parts of transdermal fibronectin, 0.06-4 parts of ergothioneine, 4-40 parts of a dispersing agent and 5-60 parts of a solvent. The preparation method of the deep water replenishing compound comprises the following steps: dispersing the hyaluronic acid sodium and the ergothioneine by using a dispersing agent according to a ratio, then adding the mixture into a solvent, stirring the mixture until the mixture is completely dissolved, finally adding transdermal fibronectin, and completely stirring the mixture to obtain the deep water replenishing compound. The deep water replenishing compound provided by the invention takes hyaluronic acid as a main efficacy substance for skin water replenishing, and is added with transdermal fibronectin to promote penetration, so that deep water replenishing is realized, and finally ergothioneine is supplemented, so that the skin barrier is improved and repaired, the water in the skin is locked, and not only can a comfortable skin feel be provided, but also the skin health is facilitated.
Description
Technical Field
The invention relates to a compound, in particular to a deep water replenishing compound and a preparation method thereof.
Background
Water is a source of life, and a series of skin problems such as dry skin, tight feeling, scurf, pruritus and the like can be caused by water shortage, and skin aging, wrinkles and color spots can be accelerated by long-term water shortage, and the skin becomes rough, dark and inelastic. In recent years, with the popularization of scientific knowledge of cosmetics, people have also come to recognize the importance of moisturizing to skin care. Moisturizing is gradually a basic demand for skin care, and various moisturizing products on the market are also in the coming of a large number. Currently, commercially available moisturizing products mainly rely on the addition of humectants such as polyhydric alcohols and the like with hygroscopicity, and achieve the moisturizing effect by adsorbing free water molecules in the air. However, it has been found that when a cosmetic having moisture absorption is applied to the skin surface, it absorbs not only water molecules in the air but also water in the internal tissues of the skin, and although the horny layer on the skin surface seems to be supplemented with water, it actually makes the internal parts of the skin more deficient in water. In addition, the stratum corneum serves as the first line of defense of the skin barrier, preventing dehydration of the underlying tissues while also preventing moisture from the skin surface from entering the deeper layers of the skin. Therefore, the actual moisturizing effect does not reach the expectation of people, and moisturizing products with deep moisturizing effect become new pursuits of people.
Hyaluronic Acid (HA) is also known as Hyaluronic Acid, and commercial Hyaluronic Acid is usually sodium hyaluronate. The polysaccharide is widely present in extracellular matrixes of tissues of human beings and vertebrates and capsules of certain streptococci, has a molecular structure of straight-chain high-molecular polysaccharide consisting of N-acetylglucosamine and D-glucuronic acid disaccharide units repeatedly, and has an average molecular weight of 103-107 Da. Carboxyl groups and other polar groups in the HA molecule can combine with water to form hydrogen bonds, and 1 gram of HA can hold 1000 times its weight of water. It is the substance with the best moisturizing performance for cosmetics found in nature at present, and is known as an ideal 'natural moisturizing factor'.
Transdermal Fibronectin (FN) is a protein active widely found in the human body and is the major non-collagenous glycoprotein in the intercellular matrix and basement membrane of the skin. FN consists of two monomers with molecular weight of 250 kDa, and has multiple functional fragments. Can be tightly combined with fibrin, heparin, collagen, DNA, cell surface receptor and other substances in vivo.
A good moisturizing product can not only increase the water retention of the horny layer in a short time, but also ensure that the skin can be moisturized for a long time. Therefore, healthy skin condition and a strong skin barrier are the prerequisite to ensure long-term moisturizing of the skin.
Ergothioneine (EGT), known as 2-mercapto-L-histidine trimethyl inner salt, is a rare natural chiral amino acid and is an important physiologically active substance in organisms. EGT not only has strong antioxidant properties, but also repairs DNA damage, inhibits apoptotic reactions and enhances cell viability. EGT is used as a skin protective agent and added into a moisturizing product, which is helpful for repairing and improving skin barrier and promoting skin moisturizing virtuous cycle.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a deep water replenishing compound prepared from hyaluronic acid, transdermal fibronectin and ergothioneine, which has a remarkable water replenishing effect and can be used as a water replenishing functional additive of a skin care product.
The invention adopts the following technical scheme for solving the technical problems:
the deep water replenishing compound comprises the following components in parts by weight: 0.05-1 part of hyaluronic acid, 0.04-2 parts of transdermal fibronectin, 0.06-4 parts of ergothioneine, 4-40 parts of a dispersing agent and 5-60 parts of a solvent.
As a preferable scheme, the deep water replenishing compound consists of the following components in parts by weight: 0.1-0.8 part of hyaluronic acid, 0.1-1 part of transdermal fibronectin, 0.1-2 parts of ergothioneine, 5-20 parts of a dispersing agent and 6-40 parts of a solvent.
As a most preferred scheme, the deep water replenishing compound consists of the following components in parts by weight: 0.5 part of hyaluronic acid, 1 part of transdermal fibronectin, 0.8 part of ergothioneine, 6 parts of a dispersing agent and 30 parts of a solvent.
Preferably, the dispersant is glycerol.
As a preferred embodiment, the solvent is deionized water.
The invention also provides a preparation method of the deep water replenishing compound, which comprises the following steps: dispersing sodium hyaluronate and ergothioneine by using a dispersing agent according to a ratio, then adding the mixture into a solvent, stirring the mixture till the mixture is completely dissolved, finally adding transdermal fibronectin, and completely stirring the mixture to obtain the deep water replenishing compound.
The invention has the beneficial effects that: (1) the natural moisturizing factor hyaluronic acid is adopted, so that the skin moisturizing cream has excellent moisturizing performance, can nourish skin and repair injury, and can provide a lubricated skin feel; when the moisturizing cream is used together with transdermal fibronectin, the permeability of moisturizing factors can be further enhanced, and deep water replenishing of skin is realized; although the addition of the ergothioneine does not have great assistance to the effect of instant water supplement, the addition of the ergothioneine is beneficial to repairing and improving skin barriers and shaping healthy skin, so that the water supplement effect is more long-acting and lasting; (2) in the invention, the deep skin water supplement is realized by mutually coordinating three components, namely hyaluronic acid, transdermal fibronectin and ergothioneine; (3) the deep water replenishing compound disclosed by the invention can realize deep water replenishing of the skin, can improve the health state of the skin after long-term use, and is a safe and effective water replenishing compound.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The deep water replenishing compound comprises the following components in parts by weight: 0.5 part of hyaluronic acid, 1 part of transdermal fibronectin, 0.8 part of ergothioneine, 6 parts of a dispersing agent and 30 parts of a solvent.
The dispersing agent is glycerol.
The solvent is water.
The preparation method of the deep water replenishing compound comprises the following steps: dispersing sodium hyaluronate and ergothioneine by using a dispersing agent according to a ratio, then adding the mixture into a solvent, stirring the mixture till the mixture is completely dissolved, finally adding transdermal fibronectin, and completely stirring the mixture to obtain the deep water replenishing compound.
Adding the deep water supplementing compound into the essence, wherein the adding amount of the deep water supplementing compound is 5%.
Example 2
The difference between the example 2 and the example 1 is that the raw material ratio is different, and the other parts are the same.
The deep water replenishing compound comprises the following components in parts by weight: 0.05 part of hyaluronic acid, 2 parts of transdermal fibronectin, 0.06 part of ergothioneine, 4 parts of a dispersing agent and 60 parts of a solvent.
Adding the deep water supplementing compound into the essence, wherein the adding amount of the deep water supplementing compound is 5%.
Example 3
Example 3 is different from example 1 in the ratio of raw materials, and the other examples are the same.
The deep water replenishing compound comprises the following components in parts by weight: 1 part of hyaluronic acid, 0.04 part of transdermal fibronectin, 4 parts of ergothioneine, 40 parts of a dispersing agent and 60 parts of a solvent.
Adding the deep water supplementing compound into the essence, wherein the adding amount of the deep water supplementing compound is 5%.
Comparative example 1
Comparative example 1 is different from example 1 in the raw material composition, and comparative example 1 does not contain hyaluronic acid.
Comparative example 2
Comparative example 2 differs from example 1 in the composition of the starting material, and comparative example 2 does not contain transdermal fibronectin.
Comparative example 3
Comparative example 3 differs from example 1 in the composition of the raw materials, and comparative example 3 does not contain ergothioneine.
Comparative example 4
Comparative example 4 differs from example 1 in the raw material composition, and comparative example 4 does not contain ergothioneine and hyaluronic acid.
Comparative example 5
Comparative example 5 differs from example 1 in the composition of the raw materials, and comparative example 5 does not contain ergothioneine and transdermal fibronectin.
Comparative example 6
Comparative example 6 differs from example 1 in the composition of the raw materials, and comparative example 5 does not contain hyaluronic acid and transdermal fibronectin.
To further demonstrate the effect of the present invention, the following test methods were provided:
human skin moisture content (MMV) test.
The test method comprises the following steps: 10 (25-35 years old) test subjects are selected, and the test subjects wipe dry with dry facial tissues to clean the faces of the test subjects. After cleaning, marking the measuring area on the left and right faces of the testee. Before formal test, the subject sits still for 30min at the temperature of 25 +/-2 ℃ and the humidity of 50 +/-2 percent without drinking water, and the human body is kept relaxed. Measuring the skin moisture content of the tested area and the blank control area of the tested subjects at 0min, 15min, 30min, 60min and 120min, completing the test of the same group of subjects by the same measuring person, and calculating the average value of the test, wherein the test results are shown in table 1.
Calculating the formula: w% (W1-W0)/W0 × 100%, note: w% — percentage increase in skin moisture content (MMV), W0 ═ moisture content before use of the sample on skin, and W1 ═ moisture content after use of the sample on skin.
TABLE 1 moisture content of human skin (MMV) test table
As can be seen from table 1, example 1 is the best mode, and by comparing example 1 with examples 2 and 3, it can be seen that different material ratios affect the properties of the composite; comparing the comparative examples 1-6 with the blank group, the three components of hyaluronic acid, transdermal fibronectin and ergothioneine have synergistic effect, and are mutually coordinated to realize the water supplement of the deep layer of the skin, and for the compound, the three components are not enough; the compound has remarkable effect on improving skin moisture content.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (3)
1. The deep water replenishing compound is characterized by comprising the following components in parts by weight: 0.1-0.8 part of hyaluronic acid, 0.1-1 part of transdermal fibronectin, 0.1-2 parts of ergothioneine, 5-20 parts of a dispersing agent and 6-40 parts of a solvent;
the dispersing agent is glycerol;
the solvent is deionized water.
2. The deep water replenishing compound of claim 1, wherein the deep water replenishing compound consists of the following components in parts by weight: 0.5 part of hyaluronic acid, 1 part of transdermal fibronectin, 0.8 part of ergothioneine, 6 parts of a dispersing agent and 30 parts of a solvent.
3. The method for preparing the deep water replenishing compound according to any one of claims 1 to 2, wherein the method for preparing the deep water replenishing compound comprises the following steps: dispersing sodium hyaluronate and ergothioneine by using a dispersing agent according to a ratio, then adding the mixture into a solvent, stirring the mixture till the mixture is completely dissolved, finally adding transdermal fibronectin, and completely stirring the mixture to obtain the deep water replenishing compound.
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| CN201910974714.5A CN110522671B (en) | 2019-10-14 | 2019-10-14 | Deep water replenishing compound and preparation method thereof |
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| CN201910974714.5A CN110522671B (en) | 2019-10-14 | 2019-10-14 | Deep water replenishing compound and preparation method thereof |
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| CN111568918B (en) * | 2020-06-24 | 2021-11-16 | 华熙生物科技股份有限公司 | Gel composition for treating inflammatory acne and preparation method thereof |
| CN111803397B (en) * | 2020-07-07 | 2022-12-02 | 华熙生物科技股份有限公司 | Scalp care product and preparation method thereof |
| CN114681451B (en) * | 2020-11-10 | 2023-11-03 | 华熙生物科技股份有限公司 | Composition of hyaluronic acid or salt thereof and/or trehalose and use thereof for stabilizing ergothioneine |
| CN114259453A (en) * | 2022-01-20 | 2022-04-01 | 中科东方细胞科技有限公司 | Sensitive muscle relieving and repairing spray and preparation method and application thereof |
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| DE102012215047A1 (en) * | 2012-08-24 | 2013-05-02 | Henkel Ag & Co. Kgaa | Use of ergothioneine e.g. for promoting keratin synthesis in the hair and as shampoos, make-up remover, face cleaners, day creams, night creams, facial masks and hair conditioners |
| KR20180118409A (en) * | 2017-04-21 | 2018-10-31 | 전주대학교 산학협력단 | Nutrition Cream Containing Ergothioneine and Its Manufacturing Method |
| CN109528610A (en) * | 2018-12-21 | 2019-03-29 | 广州科恩生物技术有限公司 | One kind repairing Essence and preparation method thereof based on private gene customization |
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