CN107343866B - Anti-wrinkle essence and preparation method thereof - Google Patents
Anti-wrinkle essence and preparation method thereof Download PDFInfo
- Publication number
- CN107343866B CN107343866B CN201710674781.6A CN201710674781A CN107343866B CN 107343866 B CN107343866 B CN 107343866B CN 201710674781 A CN201710674781 A CN 201710674781A CN 107343866 B CN107343866 B CN 107343866B
- Authority
- CN
- China
- Prior art keywords
- hyaluronic acid
- extract
- percent
- skin
- essence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses anti-wrinkle essence which comprises the following functional components in percentage by mass: 0.03-0.3% of small molecule sodium hyaluronate, 0.3-3% of acetyl chitosamine, 0.3-3% of galangal (ALPINIA GALANGA) extract, 91-3% of acetyl tetrapeptide, 1-5% of Chondrus CRISPUS (Chondrus CRISPUS) extract, 0.5-2% of ABELMOSCHUS (Hibiscus ABELMOSCHUS) seed extract, 2-6% of glycerol and 2-6% of butanediol. The galangal rhizome extract adopted in the invention is a natural plant active ingredient capable of promoting the synthesis of macromolecular hyaluronic acid. The hyaluronic acid gel can convert small molecular or fragment hyaluronic acid in skin into macromolecular hyaluronic acid, and effectively solves the problem that hyaluronic acid is difficult to absorb. The essence disclosed by the invention has excellent clinical manifestations on moisturizing, anti-aging, wrinkle-removing and other skin care effects.
Description
Technical Field
The invention relates to the field of cosmetics, and particularly relates to an anti-wrinkle essence and a preparation method thereof.
Background
Hyaluronic acid is an important moisturizing component in human skin. With the increase of age and the influence of various internal and external factors, the self-synthesis capacity of the skin is reduced, and the absence of hyaluronic acid can reduce the water-locking capacity of the skin, so that the skin is dry, loose, wrinkles and the like. Proper supplementation with hyaluronic acid can reduce these phenomena and delay the aging process of the skin. However, hyaluronic acid has a relatively high molecular weight and is difficult to be absorbed by the skin through cosmetics, and can only be injected into the underlying layers of the skin by medical means. Hyaluronic acid with small molecular weight has the similar action as polysaccharide humectant, has no effect of filling tightly, and has no ideal anti-aging and wrinkle-removing effect.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to supplement hyaluronic acid and hyaluronic acid precursors which are easy to absorb for skin and help the skin to synthesize more macromolecular hyaluronic acid, thereby achieving the purposes of moisturizing and resisting wrinkles.
In order to meet the aim, the invention selects two hyaluronic acids or precursors of small molecular hyaluronic acid and acetyl chitosamine which are easily absorbed by the skin, and extracts components capable of improving the activity of hyaluronic acid protease from galangal to help the synthesis of macromolecular hyaluronic acid on the bottom layer of the skin, thereby effectively solving the problem that the hyaluronic acid is difficult to absorb. The invention also compounds the moisturizing and anti-aging components such as acetyl tetrapeptide, the extract of the Chondrus crispus, the extract of the abelmoschus seeds and the like so as to enhance and improve the effect of the anti-wrinkle essence. The invention is realized by the following technical scheme:
the anti-wrinkle essence consists of the following functional components in percentage by mass:
small molecule sodium hyaluronate: 0.03 to 0.3 percent
Acetyl chitosamine: 0.3 to 3 percent of
Galangal (ALPINIA GALANGA) extract: 0.3 to 3 percent of
Acetyl tetrapeptide-9: 1 to 3 percent of
Chondrus CRISPUS (Chondrus CRISPUS) extract: 1 to 5 percent
Abelmoschus esculentus (HIBISCUS ABELMOSCHUS) seed extract: 0.5 to 2 percent
Glycerol: 2 to 6 percent
Butanediol: 2 to 6 percent.
Furthermore, the auxiliary component is composed of one or more of a thickening agent, a preservative and an aromatizing agent, and the mass percentage of the auxiliary component is 0.5-2%.
Further, the preparation method of the anti-wrinkle essence comprises the following steps: (1) adding water, glycerol, butanediol and thickener into a stirring pot, stirring, heating to 80 ℃, uniformly stirring, and cooling; (2) cooling to 40 ℃, sequentially adding the rest components into a stirring pot, and uniformly stirring to obtain the product.
The small molecule sodium hyaluronate disclosed by the invention has the INCI name: sodium hyaluronate, which is a sodium hyaluronate with a molecular weight of less than ten thousand, is more easily absorbed by the skin and HAS a good moisturizing effect compared with macromolecular sodium hyaluronate, and importantly, under the action of HAS-2 (a macromolecular hyaluronic acid synthase), the sodium hyaluronate can be converted into macromolecular hyaluronic acid, so that the firmness and elasticity of the skin are improved.
The acetylcysteine, INCI name, described in the present invention: the acetyl chitosamine is an active ingredient of plant origin, which can react with glucuronic acid to synthesize hyaluronic acid monomers, which are also essential substances for the synthesis of macromolecular hyaluronic acid. In addition to being an endogenous hyaluronic acid, the acetyl chitosamine also has whitening and anti-aging effects.
The galangal rhizome extract disclosed by the invention has the INCI name: the galangal (ALPINIA GALANGA) extract is an active ingredient of plant source, and can stimulate and enhance the activity of HAS-2 (a macromolecular hyaluronic acid synthetase) and improve the synthesis rate of macromolecular hyaluronic acid, so that the macromolecular hyaluronic acid in the skin is multiplied, and the effects of moisturizing, resisting aging and removing wrinkles are achieved.
Acetyl tetrapeptide-9, INCI name described in the present invention: acetyl tetrapeptide-9, an active ingredient with a definite mechanism of action, can significantly increase the gene expression of type I collagen, promote collagen synthesis, improve the firmness of the skin, and reduce wrinkles.
Chondrus crispus extract as described in the present invention, INCI name: chondrus CRISPUS (Chondrus CRISPUS) extract is a plant-derived active ingredient, and has strong hydration and moisturizing ability, synergistic effect with hyaluronic acid, and can significantly improve skin elasticity and skin texture.
The INCI name of the abelmoschus manihot extract is as follows: abelmoschus manihot (Hibiscus ABELMOSCHUS) seed extract is a plant-derived active ingredient, and can activate FGF-2 (fibroblast growth factor-2), promote collagen synthesis, and make healthy and young skin.
Glycerol, INCI name described in the present invention: glycerin, a commonly used humectant.
The butanediol of the invention, INCI name: butylene glycol, a commonly used humectant.
Compared with the prior art, the invention has the beneficial effects that:
1. for the necessary moisturizing component of the skin, namely hyaluronic acid, the invention adopts a method of combining exogenous and endogenous, greatly improves the effective utilization rate of active components, obviously increases the synthesis capacity and the quantity of hyaluronic acid in the skin on the premise of safety and high efficiency, and improves the self moisturizing and water locking capacity of the skin, thereby reducing wrinkles and smoothing the skin.
2. In the above process, small molecule hyaluronic acid and chitosamine are exogenously supplied, galangal is endogenously excited, and Chondrus crispus extract is used to further enhance the synergistic effect.
3. Collagen fibers are a structural component of skin elasticity and are an important marker for testing whether skin is aged. In the invention, the acetyl tetrapeptide-9 and the abelmoschus manihot extract can respectively promote the expression of type I collagen and fibroblast growth factor-2, compared with the method of simply supplementing collagen to the skin, the endogenous stimulation has half the effort, and can effectively improve the skin elasticity and reduce wrinkles.
4. The active ingredients adopted by the invention are mostly natural plant sources or biological agents, are mild to skin and environment-friendly, and meet the development trend of skin care products.
5. The anti-wrinkle essence completely meets various indexes in technical specifications for cosmetic safety (2015 edition) issued by the state, and the composition does not contain any toxic substance and has no potential hazard.
Detailed Description
The present invention will be further specifically described with reference to the following examples.
Examples 1 to 3:
the anti-wrinkle essence liquid compositions A, B, C in examples 1-3 are respectively prepared according to the following active raw materials in percentage by mass in the following table 1, and the preparation method is as follows:
(1) adding water, glycerol, butanediol and thickener into a stirring pot, stirring, heating to 80 deg.C, stirring, and cooling.
(2) Cooling to 40 ℃, sequentially adding the rest components into a stirring pot, and uniformly stirring to obtain the product.
Table 1: examples 1 to 3 raw material weight percentage (%)
| Component name | Example 1 | Example 2 | Example 3 |
| Small molecule hyaluronic acid | 0.05 | 0.1 | 0.2 |
| Acetylchitosamine | 0.5 | 1 | 2 |
| Alpinia galanga extract | 0.8 | 1.5 | 2.5 |
| Acetyl tetrapeptide-9 | 1 | 1.5 | 2 |
| Chondrus crispus extract | 3 | 3 | 3 |
| Abelmoschus manihot seed extract | 0.5 | 1 | 1.5 |
| Glycerol | 3 | 3 | 5 |
| Butanediol | 5 | 5 | 3 |
| Other auxiliary ingredients | 1.5 | 1.5 | 1.5 |
| Deionized water | Balance of | Balance of | Balance of |
The anti-wrinkle essence products prepared in examples 1 to 3 were clinically tested by 25 volunteers aged 40 to 65 years, and data collection and questionnaire survey were performed at weeks 4, 6 and 8, respectively. Data acquisition mainly comprises skin water content, canthus wrinkle depth, shadow area of nasal wing wrinkle gully and the like, questionnaire survey is subjective evaluation of volunteers on using the test product, and main evaluation items comprise: mild comfort, moisture retention, skin elasticity, gloss, etc., with a score from the lowest 1 to the highest 5, and finally, statistics and comparison of the available questionnaires.
The experimental results (averaged) are shown in tables 2-5:
table 2: skin moisture content (after use/before use)
| Test items | 0 week | 4 weeks | 6 weeks | 8 weeks |
| Essence A | 1 | 1.62 | 1.67 | 1.73 |
| Essence B | 1 | 1.65 | 1.71 | 1.78 |
| Essence C | 1 | 1.67 | 1.79 | 1.88 |
Table 3: canthus wrinkle depth (after use/before use)
| Test items | 0 week | 4 weeks | 6 weeks | 8 weeks |
| Essence A | 1 | 0.88 | 0.78 | 0.69 |
| Essence B | 1 | 0.82 | 0.73 | 0.63 |
| Essence C | 1 | 0.78 | 0.71 | 0.60 |
Table 4: shadow area of nose wing wrinkle gully (after use/before use)
| Test items | 0 week | 4 weeks | 6 weeks | 8 weeks |
| Essence A | 1 | 0.90 | 0.84 | 0.79 |
| Essence B | 1 | 0.89 | 0.85 | 0.76 |
| Essence C | 1 | 0.82 | 0.78 | 0.71 |
Table 5: questionnaire survey (average score)
| Test items | Mild comfort level | Moisture retention and moistening degree | Elasticity of skin | Degree of gloss |
| Essence A | 4.6 | 4.7 | 4.1 | 4.2 |
| Essence B | 4.7 | 4.8 | 4.3 | 4.5 |
| Essence C | 4.8 | 4.9 | 4.9 | 4.7 |
Questionnaire results show: more than 95% of subjects think the product is very mild and comfortable, more than 90% of subjects think the product is more moist and moist after using the product, and 85% of subjects think the glossiness and the elasticity of the skin are obviously improved.
And (3) displaying a data acquisition result: after the essence prepared by the method is used for 8 weeks, the moisture content of the skin is generally improved by about 80%, the depth of canthus wrinkles is reduced by 35-40%, and the shadow area of a nasal wing wrinkle gully is reduced by 22-25%.
In conclusion, the essence of the invention has excellent clinical manifestations on moisturizing, anti-aging, wrinkle-removing and other skin care effects.
The above-mentioned embodiments are merely preferred embodiments of the present invention, and the scope of the present invention should not be limited thereby, and those skilled in the art should not make any insubstantial changes and substitutions based on the present invention.
Claims (1)
1. The anti-wrinkle essence consists of functional components, auxiliary components and water, and is characterized in that the functional components comprise the following components in percentage by mass:
small molecule sodium hyaluronate: 0.03 to 0.3 percent
Acetyl chitosamine: 0.3 to 3 percent of
Alpinia galanga (ALPINIA)
GALANGA) extract: 0.3 to 3 percent of
Acetyl tetrapeptide-9: 1 to 3 percent of
Chondrus crispus (Chondrus crispus)
CRISPUS) extract: 1 to 5 percent
Abelmoschus manihot (HIBISCUS)
ABELMOSCHUS) seed extract: 0.5 to 2 percent
Glycerol: 2 to 6 percent
Butanediol: 2% -6%; wherein the auxiliary component comprises one or more of a thickening agent, a preservative and an aromatizing agent, and the mass percentage of the auxiliary component is 0.5-2%; the preparation method of the anti-wrinkle essence comprises the following steps: (1) adding water, glycerol, butanediol and thickener into a stirring pot, stirring, heating to 80 ℃, uniformly stirring, and cooling; (2) cooling to 40 ℃, sequentially adding the rest components into a stirring pot, and uniformly stirring to obtain the product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710674781.6A CN107343866B (en) | 2017-08-08 | 2017-08-08 | Anti-wrinkle essence and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710674781.6A CN107343866B (en) | 2017-08-08 | 2017-08-08 | Anti-wrinkle essence and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107343866A CN107343866A (en) | 2017-11-14 |
| CN107343866B true CN107343866B (en) | 2020-05-22 |
Family
ID=60257042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710674781.6A Active CN107343866B (en) | 2017-08-08 | 2017-08-08 | Anti-wrinkle essence and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107343866B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478467A (en) * | 2018-03-05 | 2018-09-04 | 贵州泛特尔细胞生物技术有限公司 | A kind of toner and preparation method thereof |
| CN108186402A (en) * | 2018-03-14 | 2018-06-22 | 广州赛美化妆品有限公司 | A kind of Essence for skin-tightening smoothing wrinkle |
| CN110279642A (en) * | 2019-08-09 | 2019-09-27 | 广州环亚化妆品科技有限公司 | Skin care composition and preparation method and application thereof |
| CN110638670A (en) * | 2019-08-26 | 2020-01-03 | 广州睿新生物科技有限公司 | High-permeability moisturizing composition, skin moisturizer and preparation method |
| CN110974745A (en) * | 2019-12-13 | 2020-04-10 | 上海新高姿化妆品有限公司 | Anti-aging composition and application thereof in skin care products |
| CN111265460A (en) * | 2020-03-13 | 2020-06-12 | 佛山市奥姿美生物科技有限公司 | Skin barrier repair compositions and uses thereof |
| CN113368022B (en) * | 2021-06-22 | 2022-07-26 | 广州欧正化妆品技术研究院有限公司 | Cream with moisturizing and skin brightening effects and preparation method thereof |
| EP4429779A1 (en) * | 2021-11-09 | 2024-09-18 | Societe Industrielle Limousine d'Application Biologique | Extract of young hibiscus flowers and cosmetic uses |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771340A (en) * | 2015-04-22 | 2015-07-15 | 湖北立天生物工程有限公司 | Novel facial mask for resisting aging and filling fine wrinkles |
| CN104800120A (en) * | 2015-04-22 | 2015-07-29 | 湖北立天生物工程有限公司 | Skin care essence capable of anti-aging and reducing fine wrinkles |
| CN105342904A (en) * | 2015-11-02 | 2016-02-24 | 嘉文丽（福建）化妆品有限公司 | Essence with skin anti-wrinkle effect |
| CN105434284A (en) * | 2015-12-31 | 2016-03-30 | 天津达仁堂京万红药业有限公司 | Moisturizing and nourishing eye serum and preparation method thereof |
-
2017
- 2017-08-08 CN CN201710674781.6A patent/CN107343866B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771340A (en) * | 2015-04-22 | 2015-07-15 | 湖北立天生物工程有限公司 | Novel facial mask for resisting aging and filling fine wrinkles |
| CN104800120A (en) * | 2015-04-22 | 2015-07-29 | 湖北立天生物工程有限公司 | Skin care essence capable of anti-aging and reducing fine wrinkles |
| CN105342904A (en) * | 2015-11-02 | 2016-02-24 | 嘉文丽（福建）化妆品有限公司 | Essence with skin anti-wrinkle effect |
| CN105434284A (en) * | 2015-12-31 | 2016-03-30 | 天津达仁堂京万红药业有限公司 | Moisturizing and nourishing eye serum and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107343866A (en) | 2017-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107343866B (en) | Anti-wrinkle essence and preparation method thereof | |
| CN105125476B (en) | A kind of anti-wrinkle essence and preparation method thereof | |
| CN105168112B (en) | A kind of crease-resistant toner and preparation method thereof | |
| CN106074304B (en) | The anti-aging cosmetics composition with smooth out wrinkles, even skin a kind of of microballoon containing Sodium Hyaluronate and peptide | |
| CN110237006B (en) | Skin care composition and mask | |
| CN111603434B (en) | Composition for improving skin wrinkles and cosmetic thereof | |
| CN110123705A (en) | A kind of moisture-keeping crease-shedding composition and skin care item | |
| CN108451893A (en) | A kind of toner and preparation method thereof with long-acting moisture-keeping efficacy | |
| CN110215423A (en) | The anti-ageing composition of reparation containing various plants extract, preparation method and application | |
| CN103385820A (en) | Repair eye cream | |
| CN109998937A (en) | cosmetic series containing glycerol glucoside (α GG) and preparation method thereof | |
| CN107802538B (en) | Anti-aging composition and cosmetic containing same | |
| CN114344181A (en) | Soothing anti-wrinkle essence lotion and preparation method thereof | |
| CN110151629B (en) | Anti-aging composition for promoting collagen synthesis and preparation method thereof | |
| CN113499305A (en) | Plant source moisturizing mask and preparation method thereof | |
| CN112137933A (en) | Composition with whitening, moisturizing and repairing effects | |
| CN107375053A (en) | A kind of ginseng and Chinese angelica root is without silicone oil shampoo and preparation method thereof | |
| CN110279628A (en) | A kind of cosmetic composition and its preparation of moisturizing of releiving | |
| CN107320357B (en) | Cosmetic containing polysaccharide | |
| CN116211783B (en) | Cosmetic composition containing dendrobium candidum extract and preparation method and application thereof | |
| CN112043659A (en) | Anti-wrinkle repair essence cream | |
| CN110934805A (en) | Skin-beautifying moisturizing cleansing water and preparation method thereof | |
| CN112022778A (en) | Composition containing yellow wine extract and application of composition in washing and caring products | |
| CN114762658A (en) | Collagen moisturizing essence and preparation method thereof | |
| CN114159333A (en) | Muscle foundation liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |