CN110974745A - Anti-aging composition and application thereof in skin care products - Google Patents

Anti-aging composition and application thereof in skin care products Download PDF

Info

Publication number
CN110974745A
CN110974745A CN201911284597.6A CN201911284597A CN110974745A CN 110974745 A CN110974745 A CN 110974745A CN 201911284597 A CN201911284597 A CN 201911284597A CN 110974745 A CN110974745 A CN 110974745A
Authority
CN
China
Prior art keywords
parts
aging
aging composition
skin
cassia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201911284597.6A
Other languages
Chinese (zh)
Inventor
丛琳
李汉玲
李雪竹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai New Cogi Cosmetic Co ltd
Original Assignee
Shanghai New Cogi Cosmetic Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai New Cogi Cosmetic Co ltd filed Critical Shanghai New Cogi Cosmetic Co ltd
Priority to CN201911284597.6A priority Critical patent/CN110974745A/en
Publication of CN110974745A publication Critical patent/CN110974745A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses an anti-aging composition and application thereof in skin care products, and relates to the technical field of skin care products. The anti-aging composition comprises sunflower flower extract, cassia wingless Cassia leaf extract, acetyl tetrapeptide-9 and acetylated sodium hyaluronate. The anti-aging composition disclosed by the invention utilizes the synergistic effect of the sunflower flower extract, the cassia winged bud leaf extract, the acetyl tetrapeptide-9 and the acetylated sodium hyaluronate, and plays a role in delaying and repairing in the skin aging process in four aspects of eliminating free radicals in vivo, repairing DNA (deoxyribonucleic acid) damage, promoting the generation of collagen and enhancing the skin barrier function respectively, so that the skin is kept in a young state.

Description

Anti-aging composition and application thereof in skin care products
Technical Field
The invention relates to the technical field of skin care products, in particular to an anti-aging composition and application thereof in skin care products.
Background
Human aging is a ubiquitous physiological process, and as the body ages, various structures and functions of the body begin to change after reaching maturity, and this physiological aging occurs in various parts of the body, with skin aging and aging being most pronounced. The aging skin is mainly characterized by: loose skin, wrinkles, dry and thin skin, pigmentation, etc. With the development of science and technology, corresponding influencing factors can be found from the cellular level aiming at the symptoms of skin aging: the content of skin collagen and elastin is reduced, so that the internal structure of the skin is loosened, and wrinkles appear; the skin becomes dry and thin because the barrier function of the skin is damaged, the hyaluronic acid is reduced, and the water is easy to lose; pigmentation is caused by photoaging, increased free radicals in the body, and damage to cellular structures and DNA. Based on the method, the method starts from four aspects of eliminating free radicals in vivo, repairing DNA damage, promoting the generation of collagen and enhancing the barrier function of skin, and delays and repairs the aged skin in all aspects, thereby achieving the anti-aging purpose.
At present, most of products of the cosmetics on the market declare anti-aging starts from increasing the collagen content of skin, and the single anti-aging way is often poor in effect and easy to repeat, so that the anti-aging effect is far from the expectation.
Disclosure of Invention
The technical problem to be solved by the invention is the deficiency of the prior art, and the existing anti-aging skin care product has single approach for solving the problem of anti-aging and poor effect.
In order to solve the above problems, the present invention proposes the following technical solutions:
in a first aspect, the invention provides an anti-aging composition, which comprises the following components in percentage by weight:
1-20 parts of sunflower flower extract, 5-30 parts of cassia wingless shell leaf extract, 90.01-1 parts of acetyl tetrapeptide, 10-30 parts of acetylated sodium hyaluronate and the balance of water.
The anti-aging composition further adopts the technical scheme that the anti-aging composition comprises the following components in percentage by weight:
10-20 parts of sunflower flower extract, 10-25 parts of cassia wingless shell leaf extract, 90.01-0.1 part of acetyl tetrapeptide, 15-25 parts of acetylated sodium hyaluronate and the balance of water.
The anti-aging composition further adopts the technical scheme that the anti-aging composition comprises the following components in percentage by weight:
10-15 parts of sunflower flower extract, 10-15 parts of cassia wingless shell leaf extract, 90.05-0.1 part of acetyl tetrapeptide, 15-20 parts of acetylated sodium hyaluronate and the balance of water.
The technical scheme is that in the anti-aging composition, the sunflower extract is prepared by the following method:
pulverizing sunflower, adding the first extractive solution, soaking at 50-80 deg.C for 2-8 hr, filtering, and drying to obtain sunflower extract;
the mass ratio of the sunflower pollen to the first extracting solution is 1: 10-50.
The further technical scheme is that the first extracting solution is a mixture of water and butanediol, wherein the mass ratio of the water to the butanediol is 1: 1-3.
The technical scheme is that in the anti-aging composition, the cassia alata leaf extract is prepared by the following method:
pulverizing Cassia alata leaves, adding the second extracting solution, soaking at 50-80 ℃ for 2-8h, filtering and drying to obtain the Cassia alata leaf extract;
the mass ratio of the cassia alata leaves to the second extracting solution is 1: 5-30.
The technical scheme is that the second extracting solution is a mixture of water and glycerol, wherein the mass ratio of the water to the glycerol is 2-5: 1.
In a second aspect, the invention further provides an anti-aging composition as described in the first aspect, which is used for preparing a skin care product in the form of lotion, essence, emulsion, skin cream, facial cream, gel and facial mask.
In a third aspect, the present invention provides a skin care product comprising the anti-aging composition of the first aspect.
The technical proposal is that the anti-aging composition accounts for 0.1-10% of the total weight of the skin care product.
Compared with the prior art, the invention can achieve the following technical effects:
the anti-aging composition provided by the invention plays a role in eliminating free radicals in vivo, repairing DNA damage, promoting the generation of collagen and enhancing the barrier function of skin by reasonably matching sunflower flower extract, cassia alata leaf extract, acetyl tetrapeptide-9 and acetylated sodium hyaluronate, and achieves the effects of comprehensively delaying skin aging and repairing aged skin by synergism.
The skin care product prepared by the anti-aging composition can effectively remove free radicals, remarkably improve the skin elasticity, reduce the skin roughness and improve the moisturizing capability and barrier function of the skin, wherein the anti-aging composition in the embodiment 1 has the removal rates of superoxide anions and hydroxyl free radicals of 67.54 percent and 94.24 percent respectively; after the anti-aging cream product of example 4 is used for 2 hours, the hydration degree change rate of the skin is as high as 32.31 percent; after 4 weeks of continuous use, the elasticity index of the skin increased to 0.8321 and the average roughness decreased to 18.34, indicating that the skin returned to a young state with significant anti-aging effect.
Detailed Description
To further illustrate the technical means and effects of the present invention, the present invention is further described with reference to the following examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.
The embodiment of the invention provides an anti-aging composition, which comprises the following components in percentage by weight:
1-20 parts of sunflower flower extract, 5-30 parts of cassia wingless shell leaf extract, 90.01-1 parts of acetyl tetrapeptide, 10-30 parts of acetylated sodium hyaluronate and the balance of water.
Preferably, the sunflower extract is present in an amount of 1 to 20 parts by weight, such as 1 part, 5 parts, 10 parts, 15 parts or 20 parts, preferably 10 to 15 parts.
Preferably, the weight part of the cassia wingnut leaf extract is 5-30 parts, such as 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or 30 parts, preferably 10-15 parts.
Preferably, the acetyl tetrapeptide-9 is present in an amount of 0.01 to 1 part by weight, for example 0.01, 0.05, 0.1, 0.5 or 1 part, preferably 0.05 to 0.1 part.
Preferably, the weight part of the acetylated sodium hyaluronate is 10-30 parts, such as 10 parts, 15 parts, 20 parts, 25 parts or 30 parts, preferably 15-20 parts.
The cassia wingpod leaf contains flavonoids, especially kaempferol-3-osophoside (K3 OS). the experimental result shows that, aiming at ultraviolet radiation, the cassia wingpod leaf extract can protect nuclear DNA and mitochondrial DNA and can promote Gadd45 α gene response, so that the repair DNA-acetyl tetrapeptide-9 can stimulate the gene expression of growth factors, structural proteins and structural protein polysaccharides, thereby forming a compact and regular collagen fiber functional network and improving the compactness and structure of the skin.
The anti-aging composition provided by the invention has the synergistic effect of eliminating free radicals in vivo, repairing DNA (deoxyribonucleic acid) damage, promoting the generation of collagen and enhancing the barrier function of skin by reasonably matching the sunflower flower extract, the cassia twig leaf extract, the acetyl tetrapeptide-9 and the acetylated sodium hyaluronate, and can comprehensively achieve the effects of delaying skin aging and repairing aged skin.
The embodiment also provides application of the anti-aging composition in preparing skin care products. The skin care product is in the form of lotion, essence, skin care emulsion, skin moistening cream, skin care gel, facial mask and foundation
The embodiment also provides a skin care product comprising the anti-aging composition. The anti-aging composition accounts for 0.1-10% of the total weight of the skin care product. For example, it may be 0.1%, 0.5%, 1%, 5% or 10%, preferably 1 to 5%.
Example 1
The embodiment provides an anti-aging composition, which comprises the following components in percentage by weight: 10 parts of sunflower flower extract, 10 parts of cassia wingnut leaf extract, acetyl tetrapeptide-90.08 parts, 20 parts of acetylated sodium hyaluronate and the balance of water.
Example 2
The embodiment provides an anti-aging composition, which comprises the following components in percentage by weight: 10 parts of sunflower flower extract, 15 parts of cassia wingnut leaf extract, 90.05 parts of acetyl tetrapeptide, 15 parts of acetylated sodium hyaluronate and the balance of water.
Example 3
The embodiment provides an anti-aging composition, which comprises the following components in percentage by weight: 15 parts of sunflower flower extract, 10 parts of cassia wingnut leaf extract, 90.1 parts of acetyl tetrapeptide, 18 parts of acetylated sodium hyaluronate and the balance of water.
Comparative example 1
The composition comprises the following components in percentage by weight: 10 parts of sunflower flower extract and the balance of water.
Comparative example 2
The composition comprises the following components in percentage by weight: 10 parts of cassia wingnut leaf extract and the balance of water.
Comparative example 3
The composition comprises the following components in percentage by weight: 90.08 parts of acetyl tetrapeptide, and the balance of water.
Comparative example 4
The composition comprises the following components in percentage by weight: 20 parts of acetylated sodium hyaluronate and the balance of water.
Comparative example 5
The composition comprises the following components in percentage by weight: 10 parts of a cassia wingnut leaf extract, acetyl tetrapeptide-90.08 parts, 20 parts of acetylated sodium hyaluronate and the balance of water.
Comparative example 6
The composition comprises the following components in percentage by weight: 10 parts of sunflower flower extract, 90.08 parts of acetyl tetrapeptide-90.08 parts of acetylated sodium hyaluronate and the balance of water.
Comparative example 7
The composition comprises the following components in percentage by weight: 10 parts of sunflower flower extract, 10 parts of cassia wingnut leaf extract, 20 parts of acetylated sodium hyaluronate and the balance of water.
Comparative example 8
The composition comprises the following components in percentage by weight: 10 parts of sunflower flower extract, 10 parts of cassia wingnut leaf extract, acetyl tetrapeptide-90.08 parts and the balance of water.
Comparative example 9
The composition comprises the following components in percentage by weight: 10 parts of sunflower seed oil, 10 parts of a cassia wingnut leaf extract, acetyl tetrapeptide-90.08 parts, 20 parts of acetylated sodium hyaluronate and the balance of water.
Example 4
The anti-aging composition of example 1 was used to prepare anti-aging creams, and the formulations are shown in table 1.
TABLE 1
Figure BDA0002317652420000061
The preparation method comprises the following steps:
(1) adding the component A into an emulsifying pot, and stirring and dissolving the component A uniformly at 80 ℃;
(2) adding the component B into an oil phase pot, and stirring and dispersing uniformly at 80 ℃;
(3) adding the component B into an emulsifying pot, homogenizing at 9000rpm for three minutes at 80 ℃, and keeping the temperature for 10 min;
(4) cooling to 50 ℃, adding the component C into an emulsifying pot, and stirring and dissolving uniformly;
(5) cooling to 37 ℃, and performing vacuum defoaming to obtain the anti-aging face cream.
Example 5
The anti-aging composition of example 1 was used to prepare an anti-aging emulsion, and the formulation is shown in table 2.
TABLE 2
Figure BDA0002317652420000071
The preparation method comprises the following steps:
(1) adding the component A into an emulsifying pot, and stirring and dissolving the component A uniformly at 80 ℃;
(2) adding the component B into an oil phase pot, and stirring and dispersing uniformly at 80 ℃;
(3) adding the component B into an emulsifying pot, homogenizing at 9000rpm for three minutes at 80 ℃, and keeping the temperature for 10 min;
(4) cooling to 50 ℃, adding the component C into an emulsifying pot, and stirring and dissolving uniformly;
(5) cooling to 37 ℃, and obtaining the anti-aging emulsion after vacuum defoaming.
Example 6
The anti-aging composition of example 1 was used to prepare an anti-aging essence, and the formulation thereof is shown in table 3.
TABLE 3
Figure BDA0002317652420000081
The preparation method comprises the following steps:
(1) adding the component A into an emulsifying pot, and stirring and dissolving the component A uniformly at 80 ℃;
(2) adding the component B into an oil phase pot, and stirring and dispersing uniformly at 80 ℃;
(3) adding the component B into an emulsifying pot, homogenizing at 9000rpm for three minutes at 80 ℃, and keeping the temperature for 10 min;
(4) cooling to 50 ℃, adding the component C into an emulsifying pot, and stirring and dissolving uniformly;
(5) cooling to 37 ℃, and defoaming in vacuum to obtain the anti-aging essence.
Example 7
The anti-aging composition of example 1 was used to prepare an anti-aging lotion, and the formulation is shown in table 4.
TABLE 4
Figure BDA0002317652420000091
The preparation method comprises the following steps:
(1) adding the component A into an emulsifying pot, and stirring and dissolving the component A uniformly at 80 ℃;
(2) cooling to 50 ℃, adding the component B into an emulsifying pot, and stirring and dissolving uniformly;
(3) cooling to 37 ℃, and defoaming in vacuum to obtain the anti-aging toning lotion.
Comparative example 10
A blank cream was prepared without the anti-aging composition in the formulation, the specific formulation being shown in table 5.
TABLE 5
Figure BDA0002317652420000092
Figure BDA0002317652420000101
The preparation method is the same as example 4.
Comparative example 11
A blank emulsion was prepared without the anti-aging composition in the formulation, the specific formulation being shown in table 6.
TABLE 6
Figure BDA0002317652420000102
The preparation method is the same as example 5.
Comparative example 12
A blank essence was prepared without an anti-aging composition in the formulation, and the specific formulation is shown in table 7.
TABLE 7
Figure BDA0002317652420000103
Figure BDA0002317652420000111
The preparation method is the same as example 6.
Comparative example 13
A blank lotion was prepared without the anti-aging composition in the formulation, the specific formulation being shown in table 8.
TABLE 8
Figure BDA0002317652420000112
The preparation method is the same as example 7.
Experiment 1-determination of superoxide anion radical scavenging Capacity
4.5mL of Tris-HCl buffer (0.05 mol/L, pH 8.2) was preheated in a water bath at 25 ℃ for 20 min. Then adding 1mL of sample and 0.4mL of 25mmol/L pyrogallol solution, mixing uniformly, reacting in a water bath at 25 ℃ for 5min, and adding 1.0mL of 8mol/L HCl to terminate the reaction. Absorbance values were measured at 299nm with Tris-HCl buffer as a reference. The test samples were the anti-aging compositions described in examples 1-3 and the compositions described in comparative examples 1-9, and the blank was prepared by replacing the sample with 1mL of the solvent of the test sample.
The superoxide anion radical scavenging rate (D) was calculated according to formula (1). The results of the experiment are shown in Table 9.
Clearance formula (%) D ═ 1- (a2/a1) x 100% (1)
In formula (1), A1 is the absorbance value of blank control; a2 is the absorbance value of the sample.
Experiment 2-determination of the scavenging Capacity for hydroxyl radical
Sequentially adding 2mmol/L FeSO into a 25mL colorimetric tube43mL,1mmol/L H2O23mL, shake well, then add 6mmol/L of salicylic acid3mL of acid, shaking up, heating in a water bath at 37 ℃ for 15min, taking out, and measuring the absorbance; adding the solutions to be tested with certain concentrations, shaking, heating in water bath for 15min, and taking out to test their absorbance. The test samples were the anti-aging compositions described in examples 1-3 and the compositions described in comparative examples 1-9, and the blank was prepared by replacing the sample with 1mL of the solvent of the test sample.
The formula (2) is a formula of clearance rate of the solution to be tested to carboxyl free radicals (OH), and the experimental result of clearance rate of hydroxyl free radicals is shown in table 9.
OH clearance (%) - (A3-a2)/a1 × 100% (2)
In the formula (2), A1 is the absorbance value of the reaction system before adding the medicine; a2 is the absorbance value of the system after OH is removed from the sample; a3 is the absorbance value of the system after blank control is cleared of OH.
TABLE 9 scavenging of free radicals by the compositions
Figure BDA0002317652420000121
Figure BDA0002317652420000131
As can be seen from the data in Table 9, the anti-aging compositions of examples 1-3 all showed excellent radical scavenging rate compared with comparative examples 1-9, which indicates that the anti-aging compositions provided by the examples of the present invention have synergistically enhanced radical scavenging ability, and the radical scavenging ability of the anti-aging compositions is slightly different due to different mixture ratios of the different components, and as can be seen from Table 9, the radical scavenging ability of example 1 is strongest.
Experiment 3-moisture retention Performance test
With the products prepared in examples 4 to 7 and comparative examples 10 to 13 as test samples, 8 healthy subjects were selected for evaluation of moisturizing efficacy. According to the light industry standard of the people's republic of China (QB/T4256-2011): cosmetic moisturizing efficacy evaluation guidelines, test samples and placebo products were applied to the forearm of the subject on a random basis, the moisture content of the skin was repeatedly measured, and the moisturizing efficacy of the test samples was evaluated. The results are shown in Table 10.
TABLE 10 hydration degree Change Rate
Figure BDA0002317652420000132
As can be seen from table 10, the samples of examples 4 to 7, whether cream, lotion, essence or lotion, prepared using the anti-aging composition of example 1 had higher hydration rate than the blank control samples of comparative examples 10 to 13, indicating that the skin care product prepared using the anti-aging composition was applicable to various formulations and enhanced the barrier function of the skin, thereby providing the skin with more excellent moisturizing ability.
Experiment 4-skin elasticity test
Selecting 40 women, wherein the women are 30-50 years old and randomly divided into 8 groups, after cleaning the face, taking a proper amount of samples of examples 4-7 and comparative examples 10-13, applying the samples to the face, slightly pressing to absorb the samples, using the samples once every morning and evening, respectively testing the skin elasticity index R2 (the negative pressure is constant at 450mbar in the testing process) of the left cheekbone part in 1, 2 and 4 weeks by using a skin elasticity tester, and taking the average value of the testing results of users. The value of the skin elasticity index 30min after cleaning of the test area was taken as the initial value. Specification of indexes: the closer the skin elasticity index R2 is to 1, the better the elasticity of the skin. The test results are as follows:
TABLE 11 skin elasticity index R2 for different periods (w)
Sample (I) 0w 1w 2w 4w
Example 4 0.6565 0.7054 0.7693 0.8321
Example 5 0.6276 0.6752 0.7386 0.7983
Example 6 0.6324 0.6925 0.7594 0.7821
Example 7 0.6451 0.6897 0.7345 0.7826
Comparative example 10 0.6783 0.6924 0.6865 0.7042
Comparative example 11 0.6509 0.6641 0.6538 0.6841
Comparative example 12 0.6421 0.6538 0.6648 0.6891
Comparative example 13 0.6602 0.6972 0.6931 0.6828
As can be seen from Table 11, the skin elasticity was improved to a higher degree after 4 weeks using the samples of examples 4 to 7 than the subjects using the blank comparative examples 10 to 13, which means that the skin became more compact and full and the anti-aging effect was significant.
Experiment 5-skin roughness average test
40 women were selected and aged between 30 and 50 years and randomly divided into 8 groups, after face cleaning, an appropriate amount of samples of examples 4 to 7 and comparative examples 10 to 13 were applied to the face, and gently absorbed, and the samples were used once a day in the morning and evening, 4 times in total, as initial values, and after 1 week, 2 weeks, and 4 weeks of the use of the anti-aging cream, respectively, the subjects cleaned the applied parts at the same time every week, and the skin average roughness of the left-eye corner area was measured using the MicroSkinII multifunctional skin mirror image analysis system, and the results are shown in table 12.
TABLE 12 average roughness of skin at different periods (w)
Sample (I) 0w 1w 2w 4w
Example 4 25.65 22.19 20.43 18.34
Example 5 24.54 23.54 21.40 18.98
Example 6 24.85 23.02 20.99 19.04
Example 7 24.59 22.35 21.94 20.43
Comparative example 10 26.72 26.43 25.32 24.81
Comparative example 11 25.43 24.31 24.52 23.95
Comparative example 12 24.51 23.43 23.32 23.84
Comparative example 13 25.64 24.59 25.61 24.06
As can be seen from Table 12, the subjects using the products of examples 4-7 showed a significant decrease in the average roughness of the skin after 4 weeks, indicating that the skin became smooth and returned to a youthful state, and the compositions had significant anti-aging and anti-wrinkle effects; the products of comparative examples 10 to 13, however, showed no significant improvement.
In conclusion, compared with a single component, the anti-aging composition provided by the embodiment of the invention has obvious effects on scavenging free radicals, repairing skin barriers, improving skin elasticity and reducing skin roughness, wherein the anti-aging composition in the embodiment 1 has more obvious effects than those in the embodiments 2 and 3, and the anti-aging composition can play a role in delaying the skin aging process through scientific proportioning, so that the anti-aging effect is achieved.
The anti-aging composition can be applied to various skin care product formulations for preparing astringent, essence, skin care emulsion, skin moistening cream, skin care gel, facial mask and foundation, and has obvious anti-aging effect.
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
While the invention has been described with reference to specific embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (10)

1. The anti-aging composition is characterized by comprising the following components in percentage by weight:
1-20 parts of sunflower flower extract, 5-30 parts of cassia wingless shell leaf extract, 90.01-1 parts of acetyl tetrapeptide, 10-30 parts of acetylated sodium hyaluronate and the balance of water.
2. The anti-aging composition according to claim 1, wherein the anti-aging composition consists of the following components in percentage by weight:
10-20 parts of sunflower flower extract, 10-25 parts of cassia wingless shell leaf extract, 90.01-0.1 part of acetyl tetrapeptide, 15-25 parts of acetylated sodium hyaluronate and the balance of water.
3. The anti-aging composition according to claim 2, wherein the anti-aging composition consists of the following components in percentage by weight:
10-15 parts of sunflower flower extract, 10-15 parts of cassia wingless shell leaf extract, 90.05-0.1 part of acetyl tetrapeptide, 15-20 parts of acetylated sodium hyaluronate and the balance of water.
4. An anti-ageing composition according to any one of claims 1 to 3, wherein the sunflower extract is prepared by:
pulverizing sunflower, adding the first extractive solution, soaking at 50-80 deg.C for 2-8 hr, filtering, and drying to obtain sunflower extract;
the mass ratio of the sunflower pollen to the first extracting solution is 1: 10-50.
5. The anti-aging composition as claimed in claim 4, wherein the first extract is a mixture of water and butanediol, wherein the mass ratio of water to butanediol is 1: 1-3.
6. The anti-aging composition according to any one of claims 1 to 3, wherein the Cassia alata leaf extract is prepared by the following method:
pulverizing Cassia alata leaves, adding the second extracting solution, soaking at 50-80 ℃ for 2-8h, filtering and drying to obtain the Cassia alata leaf extract;
the mass ratio of the cassia alata leaves to the second extracting solution is 1: 5-30.
7. The anti-aging composition according to claim 6, wherein the second extract is a mixture of water and glycerol, wherein the mass ratio of water to glycerol is 2-5: 1.
8. An anti-aging composition as defined in any one of claims 1 to 7 for use in the preparation of a skin care product in the form of a lotion, essence, emulsion, emollient cream, gel, mask.
9. A skin care product comprising the antiaging composition according to any one of claims 1 to 7.
10. The skin care product of claim 9, wherein the anti-aging composition comprises from 0.1% to 10% by weight of the total skin care product.
CN201911284597.6A 2019-12-13 2019-12-13 Anti-aging composition and application thereof in skin care products Pending CN110974745A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201911284597.6A CN110974745A (en) 2019-12-13 2019-12-13 Anti-aging composition and application thereof in skin care products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201911284597.6A CN110974745A (en) 2019-12-13 2019-12-13 Anti-aging composition and application thereof in skin care products

Publications (1)

Publication Number Publication Date
CN110974745A true CN110974745A (en) 2020-04-10

Family

ID=70093462

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201911284597.6A Pending CN110974745A (en) 2019-12-13 2019-12-13 Anti-aging composition and application thereof in skin care products

Country Status (1)

Country Link
CN (1) CN110974745A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111544324A (en) * 2020-06-05 2020-08-18 广东梵蜜琳生物科技有限公司 Composition and cosmetic for improving skin elasticity
CN112807243A (en) * 2021-01-13 2021-05-18 深圳壹博士生物科技有限公司 Composition with anti-aging effect and preparation method and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106265348A (en) * 2016-09-19 2017-01-04 广东丸美生物技术股份有限公司 A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application
CN107343866A (en) * 2017-08-08 2017-11-14 广州蜜妆生物科技有限公司 A kind of anti-wrinkle essence and preparation method thereof
CN109010243A (en) * 2018-08-28 2018-12-18 上海优康化妆品有限公司 A kind of moisturizing essence
CN109394632A (en) * 2018-12-25 2019-03-01 樊利平 A kind of Shu Min moisture retention water and preparation method thereof
CN109966471A (en) * 2015-08-28 2019-07-05 宇肽生物(东莞)有限公司 A kind of peptide composition for skin repair
CN110051587A (en) * 2019-05-04 2019-07-26 广州市爱百伊生物技术有限公司 A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109966471A (en) * 2015-08-28 2019-07-05 宇肽生物(东莞)有限公司 A kind of peptide composition for skin repair
CN106265348A (en) * 2016-09-19 2017-01-04 广东丸美生物技术股份有限公司 A kind of substrate with maintenance skin barrier and senile-resistant efficacy and its preparation method and application
CN107343866A (en) * 2017-08-08 2017-11-14 广州蜜妆生物科技有限公司 A kind of anti-wrinkle essence and preparation method thereof
CN109010243A (en) * 2018-08-28 2018-12-18 上海优康化妆品有限公司 A kind of moisturizing essence
CN109394632A (en) * 2018-12-25 2019-03-01 樊利平 A kind of Shu Min moisture retention water and preparation method thereof
CN110051587A (en) * 2019-05-04 2019-07-26 广州市爱百伊生物技术有限公司 A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
(美)培冈等: "《带着我去化妆品柜台》", 31 December 2015, 新世界出版社 *
孟潇等: ""向日葵花提取液的美白、抗氧化功效及刺激性研究"", 《香料香精化妆品》 *
马振友等: "《中西皮肤外用制剂手册》", 30 September 2019, 河南科学技术出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111544324A (en) * 2020-06-05 2020-08-18 广东梵蜜琳生物科技有限公司 Composition and cosmetic for improving skin elasticity
CN111544324B (en) * 2020-06-05 2022-09-02 广东梵蜜琳生物科技有限公司 Composition and cosmetic for improving skin elasticity
CN112807243A (en) * 2021-01-13 2021-05-18 深圳壹博士生物科技有限公司 Composition with anti-aging effect and preparation method and application thereof

Similar Documents

Publication Publication Date Title
CN111631989B (en) Anti-wrinkle composition and preparation method and application thereof
CN110974745A (en) Anti-aging composition and application thereof in skin care products
CN113350230A (en) Anti-aging composition and preparation method and application thereof
CN110433113A (en) A kind of essence dew and preparation method containing the anti-ageing composition of moisturizing
CN111568830A (en) Skin care composition and preparation method thereof
CN112545955A (en) Anti-aging repair composition and preparation method and application thereof
CN109157449B (en) Anti-aging moisturizing essence and preparation process thereof
CN108771643B (en) Nourishing and moistening repair essence
CN107349167B (en) Cosmetic composition, preparation method and application thereof
CN115414293B (en) Anti-aging composition and application thereof
CN116549307A (en) Nerve-soothing and soothing type eye and lip cleansing lotion and preparation method thereof
JP2009221201A (en) Use of orchid extract from brassocattleya marcella koss as active agent for preventing or delaying appearance of skin aging symptom
CN107669525B (en) Application of Poria extract with whitening effect and its preparation method
CN114028246B (en) Anti-aging repairing composition containing acetyl gingerol and application thereof
CN115869230A (en) Anti-wrinkle cosmetic and preparation method thereof
TW201946610A (en) Cosmetic composition including [gamma]- polyglutamic acid as active ingredient for providing excellent moisturizing and nourishing effects
CN110151667A (en) Equilibrium cream and its preparation, application method
JP2024521213A (en) Shihe car imitation cosmetic composition
KR101790203B1 (en) Cosmetic Cmposition Comprising Silicate
CN111714399B (en) Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof
CN113520947A (en) Color-fixing hair-care composition and preparation and application thereof
CN115154354B (en) Compact anti-wrinkle composition and preparation method and application thereof
KR20150105721A (en) Skin-antiaging cosmetical composition containing mixed extract of lycium chinense mill as an active ingredient
CN112972360B (en) Sensitive repairing composition and preparation method and application thereof
CN115645334B (en) Moisturizing and anti-aging cosmetic and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20200410

RJ01 Rejection of invention patent application after publication