CN115414293B - Anti-aging composition and application thereof - Google Patents

Anti-aging composition and application thereof Download PDF

Info

Publication number
CN115414293B
CN115414293B CN202211030960.3A CN202211030960A CN115414293B CN 115414293 B CN115414293 B CN 115414293B CN 202211030960 A CN202211030960 A CN 202211030960A CN 115414293 B CN115414293 B CN 115414293B
Authority
CN
China
Prior art keywords
peony
extract
aging composition
skin
alanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202211030960.3A
Other languages
Chinese (zh)
Other versions
CN115414293A (en
Inventor
毛善巧
陈庆生
孟潇
孔秋婵
张泽敏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Original Assignee
Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Huanya Cosmetic Science and Technology Co Ltd filed Critical Guangzhou Huanya Cosmetic Science and Technology Co Ltd
Priority to CN202211030960.3A priority Critical patent/CN115414293B/en
Publication of CN115414293A publication Critical patent/CN115414293A/en
Application granted granted Critical
Publication of CN115414293B publication Critical patent/CN115414293B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses an anti-aging composition and application thereof, and relates to the technical field of cosmetics. The anti-aging composition comprises the following components: peony extract, beta-alanyl hydroxyproline diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil. After the peony extract rich in polyphenols, the beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine with excellent anti-wrinkle performance, the sea buckthorn fruit oil with good oxidation resistance and the jojoba oil with excellent permeability and affinity are matched in a balanced way, the synergistic effect is effectively exerted, the skin elasticity and the skin tightening sense can be effectively improved, the fine lines are reduced, and the skin dryness is improved.

Description

Anti-aging composition and application thereof
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition and application thereof.
Background
The free radicals may cause protein damage, lipid peroxidation, nucleic acid damage, etc., thereby inducing various diseases. The antioxidation mechanism plays a role in antioxidation by providing hydrogen for the antioxidase, buffering physiological pH, chelating metal ions, capturing free radicals and the like. At present, anti-aging products are designed from various aspects of promoting and repairing collagen, resisting oxidation, resisting saccharification and the like, and related cosmetic raw materials mainly comprise peptides, retinol and derivatives thereof, natural product extracts or fermentation products and the like. However, due to unreasonable formulation design or insufficient absorption of the skin into the product, more active ingredients are often required to be added for effective treatment, which easily results in cost improvement and waste of the active ingredients. Moreover, some products are not added at all to a sufficient amount of active, especially plant extracts, or because different extraction processes result in inconsistent concentrations of active extracted, and thus the effect may be quite different for the same amount of plant extract added.
CN111544333a discloses polypeptide compositions, moisturizing and anti-aging compositions and cosmetics, wherein the moisturizing and anti-aging compositions use various plant-derived polypeptides, and the concentration of added centella asiatica extract, ginkgo leaf extract, peony flower extract and the like is also higher. CN110051593a discloses a peony essence and a preparation method thereof, and the usage amount of peony extract, squalane and other active substances in the invention is high.
Therefore, it is desirable to provide an anti-aging composition which requires less kinds and amounts of active ingredients and has a good anti-aging effect.
Disclosure of Invention
The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the invention provides an anti-aging composition which can effectively improve skin elasticity and skin tightening sense, reduce fine lines, lighten fine lines and improve skin dryness.
The invention also provides application of the anti-aging composition.
The invention also provides a cosmetic containing the anti-aging composition.
An anti-aging composition according to an embodiment of the first aspect of the present invention comprises: peony extract, beta-alanyl hydroxyproline diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil.
The anti-aging composition according to the embodiment of the invention has at least the following beneficial effects:
the anti-aging composition of the embodiment contains peony extract rich in polyphenols, beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine with excellent anti-wrinkle performance, sea buckthorn fruit oil with good anti-oxidation and anti-wrinkle effects, and jojoba oil with excellent permeability and affinity. The composition is designed through water-oil balance, absorption promotion and multidimensional anti-aging mechanism, and the peony extract, beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil achieve unexpected effects through synergistic effect, so that the composition can effectively improve skin elasticity and skin tightening sense, reduce fine lines, lighten fine lines and improve dry skin.
The peony extract is rich in polyphenols, amino acids, fatty acids, vitamins, trace elements essential to human body, and the like, and has excellent antioxidant capacity.
The sea buckthorn fruit oil can inhibit the expression of medium wave Ultraviolet (UVB) mediated metalloproteinase with wavelength of 290-320nm, and has certain anti-wrinkle and antiaging effects in combination with the elimination of superoxide radical.
The chemical structure of jojoba oil is similar to the sebum structure of human body, has good permeability and affinity, and has a certain repairing effect on skin. Can facilitate the absorption of the active substance by the skin.
Beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine is a polypeptide with a toxoid mechanism, acts on postsynaptic membranes and achieves anti-wrinkle effect by competitive binding to acetylcholine receptors
According to some embodiments of the invention, the method comprises the following steps in parts by weight: 0.5 to 5 parts of peony extract, 0.001 to 0.02 part of beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine, 0.05 to 5 parts of sea buckthorn fruit oil and 0.05 to 0.5 part of jojoba oil.
According to some embodiments of the invention, the method comprises the following steps in parts by weight: 1 to 5 parts of peony extract, 0.001 to 0.02 part of beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine, 1 to 5 parts of sea buckthorn fruit oil and 0.1 to 0.5 part of jojoba oil.
According to some embodiments of the invention, the method comprises the following steps in parts by weight: 2 to 5 parts of peony extract, 0.005 to 0.02 part of beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, 2 to 5 parts of sea buckthorn fruit oil and 0.1 to 0.2 part of jojoba oil.
According to some embodiments of the invention, the peony extract comprises at least one of peony extract, peony water, peony branch/flower/leaf extract, peony root bark extract.
According to some embodiments of the invention, in the peony extract, the mass ratio of the peony extract, the peony water, the peony branch/flower/leaf extract, the peony root bark extract is 0-1: 0 to 1:0 to 2:0 to 2.
According to some embodiments of the invention, in the peony extract, the mass ratio of the peony extract, the peony water, the peony branch/flower/leaf extract, the peony root bark extract is 0-1: 0.5 to 1:0 to 2:0 to 2.
According to some embodiments of the invention, in the peony extract, the mass ratio of the peony extract, the peony water, the peony branch/flower/leaf extract, the peony root bark extract is 0-1: 1:0 to 2:0 to 2.
According to some embodiments of the present invention, the total polyphenol content of the peony extract is greater than or equal to 10mg/mL.
According to some embodiments of the present invention, the total polyphenol content of the peony extract is 10mg/mL to 40mg/mL.
Use of the anti-aging composition of the above embodiment according to the second aspect of the embodiment of the present invention in the preparation of a cosmetic.
According to some embodiments of the invention, the cosmetic is a serum, lotion, cream or mask.
The cosmetic product according to an embodiment of the third aspect of the present invention comprises an anti-aging composition as described in the embodiment of the first aspect above and a cosmetically acceptable adjuvant. The cosmetic adopts all the technical schemes of the anti-aging composition of the embodiment, so that the anti-aging cosmetic has at least all the beneficial effects brought by the technical schemes of the embodiment.
According to some embodiments of the invention, the anti-aging composition is 0.5% to 16% by mass based on the total mass of the cosmetic.
According to some embodiments of the invention, the anti-aging composition is 2% to 11% by mass based on the total mass of the cosmetic.
According to some embodiments of the invention, the anti-aging composition comprises 4% to 11% by mass of the total mass of the cosmetic.
According to some embodiments of the invention, the adjunct comprises at least one of an emollient, an emulsifier, a thickener, a humectant, a pH adjusting agent, a skin protectant, and a preservative.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
The foregoing and/or additional aspects and advantages of the invention will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:
FIG. 1 is a chart of the texture of the canthus skin prior to use of an eye cream containing the anti-aging extract of example 1 of the present invention;
fig. 2 is a chart showing the texture of the skin at the corners of the eyes after 28 days of using the eye cream containing the anti-aging extract of example 1 of the present invention.
Detailed Description
The conception and the technical effects produced by the present invention will be clearly and completely described in conjunction with the embodiments below to fully understand the objects, features and effects of the present invention. It is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments, and that other embodiments obtained by those skilled in the art without inventive effort are within the scope of the present invention based on the embodiments of the present invention.
The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
In the following examples, peony EXTRACT (INCI name: PAEONIA SUFFRUTICOSA EXTRACT), peony root bark EXTRACT (INCI name: PAEONIA SUFFRUTICOSA ROOT BARK EXTRACT), peony branch/FLOWER/LEAF EXTRACT (INCI name: PAEONIA SUFFRUTICOSA BRANCH/FLOWER/LEAF EXTRACT), peony water (INCI name: PAEONIA SUFFRUTICOSA FLOWER WATER) were derived from Guangzhou Norgnonia Biotechnology Co., ltd.
The total polyphenol concentration and antioxidant capacity test results of the peony extract, the peony root bark extract, the peony branch/flower/leaf extract and the peony water are shown in table 1.
TABLE 1 Total polyphenol concentration and antioxidant Capacity test results
Figure BDA0003817362540000041
Sea buckthorn fruit oil, CAS number: 90106-68-6, from Beijing Sanyou Hui Zhi Biotechnology Co.
Jojoba oil is available from the chemical industry, crataegus, inc.
The beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine is derived from Viqi medicine research and development Co., ltd in Shenzhen, and has the trade name of WKPep@Erasin.
Examples
This example provides 14 example anti-aging compositions, the specific formulations of which are shown in Table 2.
Table 2 parts by weight of the components of the anti-aging compositions of examples 1 to 14
Figure BDA0003817362540000042
Figure BDA0003817362540000051
Comparative example 1
The anti-aging composition of comparative example 1 differs from example 1 only in that: the peony extract with the total polyphenol concentration of 30.22mg/mL is replaced by the peony extract with the total polyphenol concentration of 8.05 mg/mL.
Wherein the peony extract with the total polyphenol concentration of 8.05mg/mL is obtained by diluting the peony extract with water, wherein the total polyphenol concentration of the peony extract is 30.22 mg/mL.
Comparative example 2
The anti-aging composition of comparative example 2 differs from example 6 only in that: jojoba oil was replaced with equal mass of water.
Comparative example 3
The anti-aging composition of comparative example 3 differs from example 6 only in that: sea buckthorn fruit oil is replaced by water with equal mass.
Comparative example 4
The anti-aging composition of comparative example 4 differs from example 6 only in that: the peony extract is replaced by water of equal quality.
Comparative example 5
The anti-aging composition of comparative example 5 differs from example 6 only in that: the beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine is replaced by water with equal mass.
Comparative example 6
The anti-aging composition of comparative example 6 differs from example 1 only in that: the jojoba oil, the sea buckthorn oil, the peony extract and the beta-alanyl hydroxyproline diaminobutyric acid benzylamine are replaced by glycerin with equal mass.
Application example
The formulations of the essence, eye cream, mask liquid and sleeping mask used in the following application examples are shown in table 3.
Table 3 formulation of essence, eye cream, mask liquid and sleeping mask
Figure BDA0003817362540000052
Figure BDA0003817362540000061
TABLE 4 addition amount of anti-aging compositions of examples 1 to 14 and comparative examples 1 to 6 to essence, eye cream, mask lotion and sleeping mask
Figure BDA0003817362540000062
Figure BDA0003817362540000071
The preparation methods of the essence, the eye cream, the mask liquid and the sleeping mask are as follows:
1) Heating butanediol, p-hydroxyacetophenone, 1, 2-hexanediol and bis-PEG-18 methyl ether dimethyl silane to 60 ℃, and completely dissolving to obtain a pretreatment phase for later use;
2) Adding glycerol, carbomer, xanthan gum and acrylic acid (esters) or C10-30 alkanol acrylate crosslinked polymer into a stirring pot, heating to 80 ℃ and stirring until the crosslinked polymer is completely dissolved;
3) Adding glycerol stearate, PEG-100 stearate, caprylic/capric triglyceride, polydimethylsiloxane, cetostearyl alcohol, cetyl alcohol, jojoba oil and fructus Hippophae oil into oil pan, heating to 80deg.C, and dissolving completely to obtain material;
4) Pumping the material body obtained in the step 3) into the stirring pot obtained in the step 2), starting homogenizing and emulsifying, stirring at a speed of 2500-3000 r/min, homogenizing and emulsifying for 5-10 min, vacuum defoaming, cooling to 60 ℃, and adding the pretreated phase obtained in the step 1) to obtain a mixture for later use;
5) After the mixture is cooled to 45 ℃, adding aminomethyl propanol into a stirring pot, starting stirring at the rotating speed of 500-1000 r/min, and uniformly stirring; and (3) cooling to about 37 ℃, adding the beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine, the peony extract and the phenoxyethanol into a pot, stirring uniformly, cooling to room temperature, sampling, detecting, and discharging qualified materials.
1. Skin tightening efficacy test effect
40 healthy volunteers were selected, one group of two random persons. The 20 groups of volunteers used sleep masks containing the anti-aging compositions of examples 1-14, comparative examples 1-6, respectively. Subjects were administered 3 times a week for 4 weeks.
Evaluation of skin condition of the test volunteers after sample use was collected by means of a questionnaire to analyze the effect of product use. The main dimensions for collecting feedback include: skin elasticity, skin tightening sense, fine lines reduction and wrinkle lightening effect. The specific evaluation is shown by a scoring mode, 1-10 points are shown, and the higher the score is, the better the sample is favored by volunteers, and the better the effect is.
The average score for each group of individuals is shown in table 5.
TABLE 5 results of tightening efficacy analysis
Group of Skin elasticity improving effect Skin tightening effect Fine grain reducing effect Effect of lightening streak
Example 1 8.0 8.0 7.0 8.0
Example 2 9.0 9.0 8.0 9.0
Example 3 9.0 10.0 9.0 9.0
Example 4 10.0 10.0 10.0 10.0
Example 5 10.0 10.0 10.0 10.0
Example 6 10.0 10.0 10.0 10.0
Example 7 9.0 10.0 10.0 9.0
Example 8 10.0 10.0 10.0 10.0
Example 9 10.0 10.0 10.0 10.0
Example 10 10.0 10.0 10.0 10.0
Example 11 9.0 9.0 8.0 9.0
Example 12 9.0 9.0 8.0 9.0
Example 13 9.0 8.5 8.0 9.0
Example 14 8.5 8.0 8.0 8.5
Comparative example 1 4.5 5.0 5.0 5.0
Comparative example 2 5.0 6.0 5.5 5.0
Comparative example 3 5.0 5.0 4.0 5.0
Comparative example 4 4.5 5.0 4.5 5.0
Comparative example 5 4.5 4.0 4.0 4.0
Comparative example 6 1.0 1.5 1.0 1.0
As can be seen from Table 5, the anti-aging compositions of examples 1 to 14 were found to have an obvious anti-aging effect, and the anti-aging compositions of comparative examples 1 to 6 were found to have no obvious effect. This demonstrates that jojoba oil, seabuckthorn fruit oil, peony extract, beta-alanyl hydroxyproline diamido butyric acid benzylamine have significant synergy.
2. Skin elasticity test
20 healthy volunteers were selected and each of the essences containing the anti-aging compositions of examples 1 to 14 and comparative examples 1 to 6 was used. Taking skin at the inner side of the forearm as a test part, sampling 1 time a day, smearing corresponding products on the test part, and wiping off the liquid on the surface with a clean paper towel after 10 min. The skin elasticity characterization values R before and after the trial for 28d were determined according to the body Standard T/ZHCA 005-2019 cosmetic impact skin elasticity test method, respectively. The larger the characterization value R, the better the skin elasticity.
The calculation formula of the characterization value R is as follows: r=u1/U2;
wherein U1 is rebound displacement (mm) of skin after negative pressure is eliminated, and U2 is maximum stretching displacement (mm) of skin when negative pressure is loaded.
The test results are shown in Table 6.
TABLE 6 test results of skin elasticity characterization value R
Group of Before trial use After trial 28d Difference value Group of Before trial use After trial 28d Difference value
Example 1 0.4612 0.4744 0.0132 Example 11 0.4614 0.4774 0.016
Example 2 0.4618 0.4760 0.0142 Example 12 0.4615 0.4752 0.0137
Example 3 0.4623 0.4785 0.0162 Example 13 0.4627 0.4780 0.0153
Example 4 0.4630 0.4864 0.0234 Example 14 0.4602 0.4750 0.0148
Example 5 0.4635 0.4898 0.0263 Comparative example 1 0.4606 0.4688 0.0082
Example 6 0.4608 0.4882 0.0274 Comparative example 2 0.4602 0.4670 0.0068
Example 7 0.4604 0.4808 0.0204 Comparative example 3 0.4619 0.4658 0.0039
Example 8 0.4598 0.4841 0.0243 Comparative example 4 0.4605 0.4663 0.0058
Example 9 0.4602 0.4820 0.0218 Comparative example 5 0.4612 0.4680 0.0068
Example 10 0.4614 0.4888 0.0274 Comparative example 6 0.4596 0.4602 0.0006
As is clear from Table 6, the skin elasticity characterization values were improved after the test of the essence containing the anti-aging compositions of examples 1 to 14, compared with comparative examples 1 to 6, and the difference in the skin elasticity characterization values R before and after the test was not less than 0.0132.
As can be seen from the test results of example 1 and comparative example 1, although the peony extract of comparative example 1 has a certain effect even though the total polyphenol concentration is lower than 10mg/mL, the effect is significantly inferior to that of example 1.
From the test results of example 2 and examples 11-14, it can be seen that there is a difference in the skin elasticity characterization effect of the anti-aging compositions containing different peony extracts or combinations thereof. This is because peony extract is not only rich in polyphenols, but also contains amino acids, fatty acids, vitamins, trace elements essential to human body, etc., and different volunteers have differences in product absorption, etc.
From the test results of example 6 and comparative examples 2 to 5, it can be seen that the anti-aging effect is greatly impaired by the absence of any component in the anti-aging composition of the example. The skin elasticity characterization value differences of comparative examples 2-5 are respectively improved by 0.0062, 0.0033, 0.0052 and 0.0062 relative to the skin elasticity characterization value difference of comparative example 6, and the calculated theoretical skin elasticity characterization value difference of example 6 is 0.0075 which is far lower than the actual skin elasticity characterization value difference 0.0274 obtained in example 6, which indicates that the jojoba oil, the sea buckthorn fruit oil, the peony extract and the beta-alanyl hydroxypropionyl diaminobutyric acid benzyl amine have obvious synergistic effect. The calculation formula of the theoretical skin elasticity characterization value difference value is as follows: theoretical skin elasticity characterization value difference = (improvement in skin elasticity characterization value difference of comparative example 2 versus comparative example 6 + improvement in skin elasticity characterization value difference of comparative example 3 versus comparative example 6 + improvement in skin elasticity characterization value difference of comparative example 4 versus comparative example 6 + improvement in skin elasticity characterization value difference of comparative example 5 versus comparative example 6)/3.
And combining the skin tightening efficacy test result, wherein the result of the instrument test is basically consistent with the consumer self-evaluation result.
3. Anti-wrinkle effect test
(1) 30 healthy volunteers were selected, and the mask patches prepared from the mask solution containing the anti-aging composition of example 6 were used 3 times per week, respectively, for 4 weeks according to the product usage method; the skin state of the sample after use is evaluated by a questionnaire mode, and the use effect of the product is analyzed.
The analysis results are shown in Table 7.
TABLE 7 results of product tightening efficacy analysis
Index (I) Very much less obvious Not obvious Obvious and obvious Is very obvious Effective rate of
The skin dryness is improved 0 1 25 4 96.67%
The skin is tender and delicate 0 3 25 2 90.00%
Elastic lifting of skin 0 2 25 3 93.33%
Skin is more tightly packed 0 2 27 1 93.33%
Reduction of fine lines 0 3 26 1 90.00%
Effect of lightening streak 0 4 24 2 86.67%
Overall evaluation of anti-wrinkle Effect 0 4 23 3 86.67%
Wherein, the effective rate is more than or equal to 50 percent, and the product is considered to be effective, and the effective rate is = (the number of people with obvious effect+the number of people with obvious effect)/the total number of people.
As can be seen from table 7, after the subjects used for 4 weeks, 90% or more of the subjects approved that the skin dryness was improved, the skin became more tender and finer, and the skin elasticity and firmness were improved; 86.67% of subjects found a reduction in fine lines with a better lightening effect. This demonstrates that the anti-aging composition of example 6 has a pronounced fringing effect.
(2) One volunteer was selected to use an eye cream containing the anti-aging composition of example 1, and the subject was used 1 time per day and 4 weeks after use, and the subject was subjected to comparative analysis of the skin texture at the corners of the eyes using a VISIA-CR facial image analyzer.
Figures 1 and 2 are images of the texture of the canthus skin of a subject before and after use, respectively. Table 8 is an instrument analysis of the texture data of fig. 1 and 2. From the data of fig. 1,2 and table 8, the texture of the canthus was significantly improved after 4 weeks of use by the subject. This demonstrates that the anti-aging composition of example 1 has a pronounced fringing effect.
Table 8 texture data analysis results
Index (I) Before use After use
Peak height of surface maximum profile 188μm 112μm
Maximum surface profile valley depth 191μm 120μm
Total number of visible textures 10 7
4. Safety test
60 volunteers were selected, and the ages and sexes of the volunteers were randomly determined to meet the standards of "cosmetic health Specification" (2007 edition). Volunteers were randomly divided into 60 groups, and eye creams, mask solutions and essence prepared in examples 1 to 14 and comparative examples 1 to 6 were tried out, respectively, 3 to 5g were applied to facial skin, and after 10 to 20 minutes, the skin was washed, and whether there was a reaction or a delayed reaction in use and within 30 minutes after use was observed. Whether the sample caused the stimulating reaction and the reaction degree was judged according to the identification standard of Table 9, statistical analysis was performed after recording, and the detection results are shown in Table 10.
Table 9 identification criteria
Grade Authentication criteria
0 Negative reaction: no irritation and erythema
1 Suspicious reaction: mild erythema and stinging sensation
2 Weak positive reaction: erythema (red spot)
3 Strong positive reaction: erythema, papule and blister
4 Very strong positive reaction: severe edema, large foam
TABLE 10 skin irritation evaluation test results
Figure BDA0003817362540000111
Figure BDA0003817362540000121
As is clear from Table 10, the anti-aging compositions of examples 1 to 14 and comparative examples 1 to 6 were excellent in safety and did not cause adverse effects on the human body.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge of one of ordinary skill in the art without departing from the spirit of the present invention.

Claims (8)

1. An anti-aging composition comprising: peony extract, beta-alanyl hydroxyproline diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil;
the preparation method comprises the following steps of: 0.5 to 5 parts of peony extract, 0.001 to 0.02 part of beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine, 0.05 to 5 parts of sea buckthorn fruit oil and 0.05 to 0.5 part of jojoba oil;
the total polyphenol content of the peony extract is more than or equal to 10mg/mL.
2. The anti-aging composition according to claim 1, comprising, in parts by mass: 1 to 5 parts of peony extract, 0.001 to 0.02 part of beta-alanyl hydroxypropionyl diaminobutyric acid benzylamine, 1 to 5 parts of sea buckthorn fruit oil and 0.1 to 0.5 part of jojoba oil.
3. The anti-aging composition according to claim 1 or 2, wherein the peony extract comprises at least one of peony extract, peony water, peony/flower/leaf extract, peony root bark extract.
4. Use of an anti-aging composition according to any one of claims 1 to 3 in the preparation of a cosmetic.
5. The use according to claim 4, wherein the cosmetic is a lotion, an emulsion, a cream or a mask.
6. A cosmetic product, characterized in that it comprises an anti-ageing composition according to any one of claims 1 to 3 and a cosmetically acceptable auxiliary.
7. The cosmetic according to claim 6, wherein the anti-aging composition is 0.5 to 16% by mass based on the total mass of the cosmetic.
8. The cosmetic product according to claim 7, wherein the auxiliary material comprises at least one of an emollient, an emulsifier, a thickener, a humectant, a pH adjuster, a skin protectant, and a preservative.
CN202211030960.3A 2022-08-26 2022-08-26 Anti-aging composition and application thereof Active CN115414293B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202211030960.3A CN115414293B (en) 2022-08-26 2022-08-26 Anti-aging composition and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202211030960.3A CN115414293B (en) 2022-08-26 2022-08-26 Anti-aging composition and application thereof

Publications (2)

Publication Number Publication Date
CN115414293A CN115414293A (en) 2022-12-02
CN115414293B true CN115414293B (en) 2023-05-30

Family

ID=84200779

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202211030960.3A Active CN115414293B (en) 2022-08-26 2022-08-26 Anti-aging composition and application thereof

Country Status (1)

Country Link
CN (1) CN115414293B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116159006B (en) * 2023-03-03 2023-12-19 广州美兮生物科技有限公司 Composition rich in multiple peony components and application thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104523561A (en) * 2014-12-30 2015-04-22 洛阳万山高新技术应用工程有限公司 Anti-aging skin-tendering cream and preparation method thereof
CN104856928A (en) * 2015-06-03 2015-08-26 天津郁美净集团有限公司 Anti-wrinkle and anti-aging cosmetic and preparation method thereof
CN107822936A (en) * 2017-12-08 2018-03-23 佛山汇沐化学科技有限公司 A kind of anti-aging composition of skin wrinkle resisting
CN112807243A (en) * 2021-01-13 2021-05-18 深圳壹博士生物科技有限公司 Composition with anti-aging effect and preparation method and application thereof
CN112807262A (en) * 2021-01-26 2021-05-18 广州华厦生物制药有限公司 Plant efficient moisturizing repair cream
CN113116755A (en) * 2021-05-27 2021-07-16 山东花物堂生物科技有限公司 Skin care composition for promoting penetration and preparation method and application thereof
WO2021218039A1 (en) * 2020-04-29 2021-11-04 上海林清轩生物科技有限公司 Biomimetic and camellia extract-containing skin barrier repair composition and application thereof
CN114259445A (en) * 2022-01-21 2022-04-01 珀莱雅化妆品股份有限公司 Composition with anti-wrinkle and anti-oxidation effects and microcapsule preparation method thereof
CN114259442A (en) * 2021-12-31 2022-04-01 云南贝泰妮生物科技集团股份有限公司 Anti-aging composition and anti-aging cosmetic containing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002327094A1 (en) * 2002-08-14 2004-03-03 Fancl Corporation Cosmetics
US20080107679A1 (en) * 2003-08-14 2008-05-08 Natalie Dilallo Skin care compositions including hexapeptide complexes and methods of their manufacture

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104523561A (en) * 2014-12-30 2015-04-22 洛阳万山高新技术应用工程有限公司 Anti-aging skin-tendering cream and preparation method thereof
CN104856928A (en) * 2015-06-03 2015-08-26 天津郁美净集团有限公司 Anti-wrinkle and anti-aging cosmetic and preparation method thereof
CN107822936A (en) * 2017-12-08 2018-03-23 佛山汇沐化学科技有限公司 A kind of anti-aging composition of skin wrinkle resisting
WO2021218039A1 (en) * 2020-04-29 2021-11-04 上海林清轩生物科技有限公司 Biomimetic and camellia extract-containing skin barrier repair composition and application thereof
CN112807243A (en) * 2021-01-13 2021-05-18 深圳壹博士生物科技有限公司 Composition with anti-aging effect and preparation method and application thereof
CN112807262A (en) * 2021-01-26 2021-05-18 广州华厦生物制药有限公司 Plant efficient moisturizing repair cream
CN113116755A (en) * 2021-05-27 2021-07-16 山东花物堂生物科技有限公司 Skin care composition for promoting penetration and preparation method and application thereof
CN114259442A (en) * 2021-12-31 2022-04-01 云南贝泰妮生物科技集团股份有限公司 Anti-aging composition and anti-aging cosmetic containing same
CN114259445A (en) * 2022-01-21 2022-04-01 珀莱雅化妆品股份有限公司 Composition with anti-wrinkle and anti-oxidation effects and microcapsule preparation method thereof

Also Published As

Publication number Publication date
CN115414293A (en) 2022-12-02

Similar Documents

Publication Publication Date Title
CN111297754B (en) Day-tightening oil-control essence and preparation method thereof
EP1082098B1 (en) Cosmetic treatment method for fighting against skin ageing effects
CN106890114B (en) Topical composition comprising extracts of pichia anomala and chicory root
CN108969444B (en) Black eye removing, anti-wrinkle firming and repairing eye cream and preparation method thereof
CN110123705B (en) Moisturizing and anti-wrinkle composition and skin care product
US20160128924A1 (en) Composition for Improving Skin Condition Containing a Vitamin Mixture
CN115414293B (en) Anti-aging composition and application thereof
CN111991286A (en) Eye cream composition for fading fine wrinkles and preparation method thereof
CN110711163A (en) Instant firming essence and preparation method and application thereof
JP3991164B2 (en) Cosmetic composition comprising jujube extract and walnut extract
CN104027280A (en) Anti-aging traditional Chinese medicine composition and application of anti-aging traditional Chinese medicine composition in cosmetics
CN111434332A (en) Nourishing and repairing emulsion and preparation method thereof
EP3801778B1 (en) Use of a bixa orellana extract
CN109330922B (en) Scalp anti-aging composition
CN108653037B (en) Skin conditioner composition, application thereof and whitening mask
JP3432175B2 (en) Cell growth promotion cosmetics
CN114159333B (en) Myobase liquid and preparation method thereof
CN115414289A (en) Cordyceps flower cosmetics and preparation method thereof
CN115089537A (en) Deep repair essence and preparation method thereof
CN114748385A (en) Composition and eye cream with effects of resisting wrinkles, removing dark eye circles and improving eye bags
JP2019059698A (en) Food composition and external preparation compositions for improved skin conditions
KR100205499B1 (en) Basic cosmetic compositions having wrinkle-suppressing effect without skin-irritation
CN112716849A (en) Anti-chap skin cream containing camellia oleifera extract
CN115721596B (en) Repairing anti-wrinkle face beautifying cream
CN110755343A (en) Emulsion for old people and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant