CN115414293A - Anti-aging composition and application thereof - Google Patents

Anti-aging composition and application thereof Download PDF

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CN115414293A
CN115414293A CN202211030960.3A CN202211030960A CN115414293A CN 115414293 A CN115414293 A CN 115414293A CN 202211030960 A CN202211030960 A CN 202211030960A CN 115414293 A CN115414293 A CN 115414293A
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peony
extract
aging composition
skin
aging
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CN115414293B (en
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毛善巧
陈庆生
孟潇
孔秋婵
张泽敏
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Guangzhou Huanya Cosmetic Science and Technology Co Ltd
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Guangzhou Huanya Cosmetic Science and Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention discloses an anti-aging composition and application thereof, and relates to the technical field of cosmetics. The anti-aging composition comprises the following components: peony extract, beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil. After the peony extract rich in polyphenols, the beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine with excellent anti-wrinkle performance, the seabuckthorn fruit oil with excellent oxidation resistance and the jojoba oil with excellent permeability and affinity are balanced and matched, the synergistic effect is effectively exerted, the elasticity and the skin tightness of the skin can be effectively improved, fine wrinkles are reduced, the fine wrinkles are faded, and the skin dryness is improved.

Description

Anti-aging composition and application thereof
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging composition and application thereof.
Background
Free radicals can cause protein damage, lipid peroxidation, nucleic acid damage, etc., which in turn can induce various diseases. The antioxidant mechanism plays an antioxidant role by providing hydrogen to antioxidant enzymes, buffering physiological pH, chelating metal ions, trapping free radicals, and the like. At present, anti-aging products are designed from various aspects such as promotion and repair of collagen, oxidation resistance, saccharification resistance and the like, and related cosmetic raw materials mainly comprise peptides, retinol and derivatives thereof, natural product extracts or fermentation products and the like. However, the formula design is not reasonable enough, or the skin can not absorb the product well enough, so that the effect can be achieved only by adding more active ingredients, and thus the cost is increased and the active ingredients are wasted easily. Moreover, some products do not add sufficient active, especially plant extracts, at all, or because of different extraction processes, resulting in inconsistent concentrations of the extracted active, and therefore may be more or less effective for adding the same amount of plant extract.
CN111544333A discloses a polypeptide composition, a moisturizing and anti-aging composition and a cosmetic, wherein the moisturizing and anti-aging composition uses various plant-derived polypeptides, and the added concentrations of centella extract, ginkgo leaf extract, peony extract and the like are also high. CN110051593A discloses a peony essence and a preparation method thereof, and the usage amount of peony extract, squalane and other active substances in the invention is higher.
Therefore, it is desirable to provide an anti-aging composition requiring less kinds and amounts of active ingredients and having a good anti-aging effect.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art. Therefore, the anti-aging composition provided by the invention can effectively improve the elasticity and the tightness of the skin, reduce fine wrinkles, fade fine wrinkles and improve the dryness of the skin.
The invention also provides application of the anti-aging composition.
The invention also provides a cosmetic containing the anti-aging composition.
An anti-aging composition according to an embodiment of the first aspect of the present invention comprises: peony extract, beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil.
The anti-aging composition according to the embodiment of the invention has at least the following beneficial effects:
the anti-aging composition of the examples contains peony extract rich in polyphenols, beta-alanyl hydroxyproline diaminobutyric acid benzylamine having excellent anti-wrinkle properties, seabuckthorn fruit oil having good anti-oxidation and anti-wrinkle effects, and jojoba oil having excellent permeability and affinity. The design is carried out through a water-oil balance, absorption promotion and multi-dimensional anti-aging mechanism, the peony extract, the beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, the seabuckthorn fruit oil and the jojoba oil achieve unexpected effects through synergistic effect, and the effects of effectively improving skin elasticity and skin tightness, reducing fine wrinkles, fading fine wrinkles and improving skin dryness are achieved.
The peony extract is rich in polyphenols, amino acids, fatty acids, vitamins, trace elements essential to human bodies and the like, and has excellent oxidation resistance.
The fructus Hippophae oil can inhibit expression of metalloprotease mediated by medium wave Ultraviolet (UVB) with wavelength of 290-320nm, and has effects of removing wrinkle and resisting aging by eliminating superoxide radical.
The chemical structure of the jojoba oil is similar to that of human sebum, so that the jojoba oil has good permeability and affinity and has a certain repairing effect on skin. Can help the skin absorb the active.
Beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine is a polypeptide with a carnitine-like mechanism, acts on a postsynaptic membrane, and realizes an anti-wrinkle effect by competitively combining with an acetylcholine receptor
According to some embodiments of the invention, the method comprises the following steps in parts by mass: 0.5 to 5 portions of peony extract, 0.001 to 0.02 portion of beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, 0.05 to 5 portions of sea buckthorn fruit oil and 0.05 to 0.5 portion of jojoba oil.
According to some embodiments of the invention, the method comprises the following steps in parts by mass: 1 to 5 parts of peony extract, 0.001 to 0.02 part of beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, 1 to 5 parts of seabuckthorn fruit oil and 0.1 to 0.5 part of jojoba oil.
According to some embodiments of the invention, the method comprises the following steps in parts by mass: 2 to 5 parts of peony extract, 0.005 to 0.02 part of beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, 2 to 5 parts of sea buckthorn fruit oil and 0.1 to 0.2 part of jojoba oil.
According to some embodiments of the invention, the peony extract comprises at least one of a peony extract, peony water, a peony branch/flower/leaf extract, a peony root bark extract.
According to some embodiments of the present invention, in the peony extract, the mass ratio of the peony extract, the peony water, the peony branch/flower/leaf extract and the peony root-bark extract is 0-1: 0 to 1:0 to 2:0 to 2.
According to some embodiments of the present invention, in the peony extract, the mass ratio of the peony extract, the peony water, the peony branch/flower/leaf extract and the peony root-bark extract is 0 to 1:0.5 to 1:0 to 2:0 to 2.
According to some embodiments of the present invention, in the peony extract, the mass ratio of the peony extract, the peony water, the peony branch/flower/leaf extract and the peony root-bark extract is 0 to 1:1:0 to 2:0 to 2.
According to some embodiments of the invention, the total polyphenol content of the peony extract is ≥ 10mg/mL.
According to some embodiments of the invention, the total polyphenol content of the peony extract is from 10mg/mL to 40mg/mL.
Use of the anti-aging composition of the above embodiments according to embodiments of the second aspect of the present invention in the preparation of a cosmetic.
According to some embodiments of the invention, the cosmetic is a serum, lotion, cream or mask.
A cosmetic product according to an embodiment of the third aspect of the invention comprises an anti-aging composition as described in the embodiment of the first aspect above and a cosmetically acceptable vehicle. Since the cosmetics adopt all the technical solutions of the anti-aging composition of the above embodiments, at least all the beneficial effects brought by the technical solutions of the above embodiments are obtained.
According to some embodiments of the invention, the anti-aging composition is present in an amount of 0.5% to 16% by mass based on the total mass of the cosmetic.
According to some embodiments of the invention, the anti-aging composition is present in an amount of 2% to 11% by mass based on the total mass of the cosmetic.
According to some embodiments of the invention, the anti-aging composition is present in an amount of 4 to 11% by mass based on the total mass of the cosmetic.
According to some embodiments of the invention, the excipient comprises at least one of an emollient, an emulsifier, a thickener, a humectant, a pH adjuster, a skin protectant, and a preservative.
Additional features and advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
FIG. 1 is a skin texture map of the canthus before eye cream using the anti-aging extract of example 1 of the present invention;
fig. 2 is a diagram showing the skin texture of the canthus 28 days after using the eye cream containing the anti-aging extract of example 1 of the present invention.
Detailed Description
The idea of the invention and the resulting technical effects will be clearly and completely described below in connection with the embodiments, so that the objects, features and effects of the invention can be fully understood. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and other embodiments obtained by those skilled in the art without inventive efforts are within the protection scope of the present invention based on the embodiments of the present invention.
The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
In the following examples, the peony FLOWER EXTRACT (INCI name: paeonia SUFFRUTICOSA EXTRACT), the peony ROOT-BARK EXTRACT (INCI name: paeonia SUFFRUTICOSA ROOT BARK EXTRACT), the peony BRANCH/FLOWER/LEAF EXTRACT (INCI name: paeonia SUFFRUTICOSA Branch/FLOWER/LEAF EXTRACT), and the peony WATER (INCI name: paeonia SUFFRUTICOSA FLOWER WATER) are derived from Bignonian Guangzhou Biotech, inc.
The total polyphenol concentration and antioxidant capacity test results of the peony extract, the peony root bark extract, the peony branch/flower/leaf extract and the peony water are shown in table 1.
TABLE 1 Total Polyphenol concentration and antioxidant Capacity test results
Figure BDA0003817362540000041
Seabuckthorn fruit oil, CAS No.: 90106-68-6, from Sanyou Huizhi Biotechnology, inc. of Beijing.
Jojoba oil, available from clarien chemical technology (shanghai) ltd.
The beta-alanyl hydroxyproline diaminobutyric benzylamine is derived from Weiqi medicine research and development Limited company in Shenzhen, and has the trade name of Weizheng Qing WKPep @ Erasin.
Examples
This example provides 14 examples of anti-aging compositions, the specific formulations of which are shown in Table 2.
TABLE 2 parts by weight of the components of the anti-aging compositions of examples 1 to 14
Figure BDA0003817362540000042
Figure BDA0003817362540000051
Comparative example 1
The anti-aging composition of comparative example 1 differs from example 1 only in that: the peony extract with the total polyphenol concentration of 30.22mg/mL is replaced by the peony extract with the total polyphenol concentration of 8.05 mg/mL.
Wherein the flos moutan extract with total polyphenol concentration of 8.05mg/mL is obtained by diluting flos moutan extract with water, wherein the total polyphenol concentration of 30.22 mg/mL.
Comparative example 2
The anti-aging composition of comparative example 2 differs from example 6 only in that: jojoba oil was replaced with equal quality water.
Comparative example 3
The anti-aging composition of comparative example 3 differs from example 6 only in that: the sea buckthorn fruit oil is replaced by water with equal mass.
Comparative example 4
The anti-aging composition of comparative example 4 differs from example 6 only in that: the peony extract is replaced by water with equal mass.
Comparative example 5
The anti-aging composition of comparative example 5 differs from example 6 only in that: beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine is replaced by water with equal mass.
Comparative example 6
The anti-aging composition of comparative example 6 differs from example 1 only in that: the jojoba oil, the seabuckthorn fruit oil, the peony extract and the beta-alanyl hydroxy prolyl diaminobutyric benzylamine are replaced by glycerol with equal mass.
Application example
The formulations of essence, eye cream, mask solution and sleep mask used in the following application examples are shown in table 3.
TABLE 3 formula of essence, eye cream, facial mask liquid and sleeping mask
Figure BDA0003817362540000052
Figure BDA0003817362540000061
Table 4 addition amount of the anti-aging compositions of examples 1 to 14 and comparative examples 1 to 6 to essence, eye cream, mask solution and sleep mask
Figure BDA0003817362540000062
Figure BDA0003817362540000071
The preparation methods of the essence, the eye cream, the facial mask liquid and the sleep mask are as follows:
1) Heating butanediol, p-hydroxyacetophenone, 1, 2-hexanediol, and bis-PEG-18 methyl ether dimethylsilane to 60 deg.C, and dissolving completely to obtain a pretreatment phase;
2) Adding glycerol, carbomer, xanthan gum, and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer into a stirring pot, heating to 80 deg.C, and stirring to dissolve completely;
3) Adding glyceryl stearate, PEG-100 stearate, caprylic/capric triglyceride, polydimethylsiloxane, cetearyl alcohol, cetyl alcohol, jojoba oil, and fructus Hippophae oil into oil pan, heating to 80 deg.C, and dissolving completely to obtain material body;
4) Pumping the material body in the step 3) into the stirring pot in the step 2), starting homogenizing and emulsifying, wherein the stirring rotating speed is 2500-3000 r/min, the homogenizing and emulsifying time is 5-10 min, defoaming in vacuum, and adding the pretreatment phase in the step 1) when cooling to 60 ℃ to obtain a mixture for later use;
5) After the mixture is cooled to 45 ℃, adding aminomethyl propanol into a stirring pot, starting stirring at the rotating speed of 500-1000 r/min, and uniformly stirring; cooling to about 37 deg.C, adding beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, peony extract and phenoxyethanol into the pot, stirring, cooling to room temperature, sampling, detecting, and discharging.
1. Skin tightening efficacy test effect
40 healthy volunteers were selected, randomized into two groups. 20 groups of volunteers used sleep masks containing the anti-aging compositions of examples 1-14 and comparative examples 1-6, respectively. The subjects were used 3 times per week for 4 consecutive weeks.
Evaluation of the skin condition of the test volunteers after sample application was collected by means of questionnaires to analyze the effect of the product in use. The major dimensions of collecting feedback include: skin elasticity, skin tightness, fine wrinkle reduction and wrinkle reduction effects. The specific evaluation is embodied in a scoring mode, the score is 1-10 points, the higher the score is, the more the sample is loved by the volunteer, and the better the effect is.
The average score results for each panel are shown in table 5.
Table 5 results of tightening efficacy analysis
Group of Skin elasticity improving effect Skin firmness feeling improving effect Fine grain reduction effect Light vein effect
Example 1 8.0 8.0 7.0 8.0
Example 2 9.0 9.0 8.0 9.0
Example 3 9.0 10.0 9.0 9.0
Example 4 10.0 10.0 10.0 10.0
Example 5 10.0 10.0 10.0 10.0
Example 6 10.0 10.0 10.0 10.0
Example 7 9.0 10.0 10.0 9.0
Example 8 10.0 10.0 10.0 10.0
Example 9 10.0 10.0 10.0 10.0
Example 10 10.0 10.0 10.0 10.0
Example 11 9.0 9.0 8.0 9.0
Example 12 9.0 9.0 8.0 9.0
Example 13 9.0 8.5 8.0 9.0
Example 14 8.5 8.0 8.0 8.5
Comparative example 1 4.5 5.0 5.0 5.0
Comparative example 2 5.0 6.0 5.5 5.0
Comparative example 3 5.0 5.0 4.0 5.0
Comparative example 4 4.5 5.0 4.5 5.0
Comparative example 5 4.5 4.0 4.0 4.0
Comparative example 6 1.0 1.5 1.0 1.0
As can be seen from Table 5, the anti-aging compositions of examples 1 to 14 were found to have significant anti-aging effects, and the anti-aging compositions of comparative examples 1 to 6 were not found to have significant effects, according to the evaluation by the subjects. The results show that the jojoba oil, the sea buckthorn fruit oil, the peony extract and the beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine have obvious synergistic effect.
2. Skin elasticity test
20 healthy volunteers were selected and the essences containing the anti-aging compositions of examples 1 to 14 and comparative examples 1 to 6 were used, respectively. Taking the skin on the inner side of forearm as the test part, trying for 1 time every day, smearing the corresponding product on the test part, and wiping off the liquid on the surface with clean paper towel after 10 min. And respectively measuring the skin elasticity characterization value R before trial and after trial for 28d according to a group standard T/ZHCA 005-2019 skin elasticity influence test method for cosmetics. The larger the characteristic value R, the better the skin elasticity.
The formula for the calculation of the characteristic value R is: r = U1/U2;
in the formula, U1 is the rebound displacement (mm) of the skin after the negative pressure is eliminated, and U2 is the maximum stretching displacement (mm) of the skin when the negative pressure is applied.
The test results are shown in table 6.
TABLE 6 test results for skin elasticity characterization R
Group of Before trial use After trial for 28 days Difference value Group of Before trial After trial for 28 days Difference value
Example 1 0.4612 0.4744 0.0132 Example 11 0.4614 0.4774 0.016
Example 2 0.4618 0.4760 0.0142 Example 12 0.4615 0.4752 0.0137
Example 3 0.4623 0.4785 0.0162 Example 13 0.4627 0.4780 0.0153
Example 4 0.4630 0.4864 0.0234 Example 14 0.4602 0.4750 0.0148
Example 5 0.4635 0.4898 0.0263 Comparative example 1 0.4606 0.4688 0.0082
Example 6 0.4608 0.4882 0.0274 Comparative example 2 0.4602 0.4670 0.0068
Example 7 0.4604 0.4808 0.0204 Comparative example 3 0.4619 0.4658 0.0039
Example 8 0.4598 0.4841 0.0243 Comparative example 4 0.4605 0.4663 0.0058
Example 9 0.4602 0.4820 0.0218 Comparative example 5 0.4612 0.4680 0.0068
Example 10 0.4614 0.4888 0.0274 Comparative example 6 0.4596 0.4602 0.0006
As can be seen from Table 6, compared with comparative examples 1 to 6, after the essences containing the anti-aging compositions of examples 1 to 14 were tried, the skin elasticity characterization value was improved, and the difference of the skin elasticity characterization value R before and after the trial was not less than 0.0132.
From the test results of example 1 and comparative example 1, it can be seen that although the peony extract of comparative example 1 has a total polyphenol concentration of less than 10mg/mL, the effect is significantly inferior to that of example 1.
As can be seen from the test results of example 2 and examples 11-14, there is a difference in skin elasticity characterization effect of anti-aging compositions containing different peony extracts or combinations thereof. The peony extract is rich in polyphenols, amino acids, fatty acids, vitamins, trace elements essential to human bodies and other components, and different volunteers have different product absorption and the like.
As can be seen from the test results of example 6 and comparative examples 2-5, the anti-aging effect would be compromised in the absence of any of the components of the anti-aging compositions of the examples. Comparative examples 2-5 were raised by 0.0062, 0.0033, 0.0052, 0.0062, respectively, relative to the difference in skin elasticity characterization values of comparative example 6, and the calculated difference in theoretical skin elasticity characterization values of example 6 was 0.0075, which is much lower than the difference in actual skin elasticity characterization values of example 6 by 0.0274, which indicates that there is a significant synergistic effect between jojoba oil, seabuckthorn fruit oil, peony extract and β -alanyl hydroxy prolyl diaminobutyric acid benzylamine. Wherein, the calculation formula of the difference value of the theoretical skin elasticity characterization value is as follows: theoretical skin elasticity characteristic value difference = (rise of skin elasticity characteristic value difference of comparative example 2 relative to comparative example 6 + rise of skin elasticity characteristic value difference of comparative example 3 relative to comparative example 6 + rise of skin elasticity characteristic value difference of comparative example 4 relative to comparative example 6 + rise of skin elasticity characteristic value difference of comparative example 5 relative to comparative example 6)/3.
And combining the skin tightening efficacy test result, the test result of the instrument is basically consistent with the self-evaluation result of the consumer.
3. Anti-wrinkle Effect test
(1) Selecting 30 healthy volunteers, using facial mask patches prepared from facial mask solution containing the anti-aging composition of example 6, respectively, the subjects used 3 times per week for 4 weeks according to the product usage method; the skin condition of the samples after use was evaluated by means of questionnaires, and the use effect of the products was analyzed.
The analysis results are shown in Table 7.
Table 7 product tightening efficacy analysis results
Index (I) Very little apparent Is not obvious Is obvious to Is quite obvious High efficiency
The skin dryness is improved 0 1 25 4 96.67%
The skin is more tender and fine 0 3 25 2 90.00%
Skin elasticity improvement 0 2 25 3 93.33%
Firmer skin 0 2 27 1 93.33%
Reduction of fine lines 0 3 26 1 90.00%
Light vein effect 0 4 24 2 86.67%
Overall evaluation of anti-wrinkle Effect 0 4 23 3 86.67%
Wherein, the effective rate is more than or equal to 50 percent, the product is considered to be effective, and the effective rate is not less than the effective rate (the number of people with obvious effect plus the number of people with very obvious effect)/the total number of people.
According to table 7, after the test subjects used for 4 weeks, more than 90% of the test subjects approved that the skin dryness is improved, the skin becomes more tender and delicate, and the skin elasticity and firmness are improved; 86.67% of the subjects found a reduction in fine lines with a better pale line effect. This demonstrates that the anti-aging composition of example 6 has a pronounced lightening effect.
(2) One volunteer was selected to use the eye cream containing the antiaging composition of example 1, and the subjects used 1 time per day, and after 4 weeks, the subjects were subjected to comparative analysis of the skin texture of the canthus using a VISIA-CR facial image analyzer.
Fig. 1 and 2 are the pictures of the skin texture of the eye corner of a subject before and after use, respectively. Table 8 shows the texture data analysis of fig. 1 and 2 for the instrument. As can be seen from the data in fig. 1, fig. 2 and table 8, the texture of the corners of the eyes was significantly improved after 4 weeks of use by the subjects. This demonstrates that the anti-aging composition of example 1 has a pronounced lightening effect.
Table 8 texture data analysis results
Index (es) Before use After use
Maximum profile peak height of surface 188μm 112μm
Maximum profile valley depth of surface 191μm 120μm
Total number of visible textures 10 7
4. Safety test
60 volunteers were selected, and the ages and sexes of the volunteers were randomly determined to meet the standards of the cosmetic hygiene code (2007 edition). The volunteers were randomly divided into 60 groups, and 3 to 5g of the eye cream, facial mask liquid and essence prepared in examples 1 to 14 and comparative examples 1 to 6 were applied to the facial skin, washed after 10 to 20 minutes, and observed whether there was a reaction or a delayed reaction during and 30 minutes after use. According to the identification standard in Table 9, whether the sample causes the irritant reaction and the reaction degree are judged, and after recording, statistical analysis is carried out, and the detection result is shown in Table 10.
TABLE 9 identification standards
Grade Identification criteria
0 Negative reaction: has no irritation and erythema
1 And (3) suspicious reaction: mild erythema and tingling sensation
2 Weak positive reaction: erythema
3 Strong positive reaction: erythema, papules, blisters
4 Extremely strong positive reaction: severe edema and bulla
TABLE 10 evaluation test results of skin irritation
Figure BDA0003817362540000111
Figure BDA0003817362540000121
As can be seen from Table 10, the anti-aging compositions of examples 1 to 14 and comparative examples 1 to 6 have excellent safety without causing adverse reactions to human body.
The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the gist of the present invention.

Claims (10)

1. An anti-aging composition, comprising: peony extract, beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, sea buckthorn fruit oil and jojoba oil.
2. The anti-aging composition according to claim 1, comprising, in parts by mass: 0.5 to 5 portions of peony extract, 0.001 to 0.02 portion of beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, 0.05 to 5 portions of seabuckthorn fruit oil and 0.05 to 0.5 portion of jojoba oil.
3. The anti-aging composition according to claim 1, comprising, in parts by mass: 1 to 5 parts of peony extract, 0.001 to 0.02 part of beta-alanyl hydroxy prolyl diaminobutyric acid benzylamine, 1 to 5 parts of seabuckthorn fruit oil and 0.1 to 0.5 part of jojoba oil.
4. The anti-aging composition according to any one of claims 1 to 3, wherein the peony extract comprises at least one of a peony extract, peony water, peony branch/flower/leaf extract, and peony root bark extract.
5. The anti-aging composition according to any one of claims 1 to 3, wherein the peony extract has a total polyphenol content of 10mg/mL or more.
6. Use of the anti-aging composition according to any one of claims 1 to 5 for the preparation of cosmetics.
7. The use according to claim 6, wherein the cosmetic is a serum, a lotion, a cream or a mask.
8. A cosmetic comprising the antiaging composition as claimed in any one of claims 1 to 5 and a cosmetically acceptable auxiliary.
9. The cosmetic according to claim 8, wherein the anti-aging composition is present in an amount of 0.5 to 16% by mass based on the total mass of the cosmetic.
10. The cosmetic according to claim 8, wherein the auxiliary material comprises at least one of an emollient, an emulsifier, a thickener, a humectant, a pH adjuster, a skin protectant, and a preservative.
CN202211030960.3A 2022-08-26 2022-08-26 Anti-aging composition and application thereof Active CN115414293B (en)

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