CN110051587A - A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates - Google Patents
A kind of preparation method and application of the anti-apolexis composition containing a variety of sodium hyaluronates Download PDFInfo
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- CN110051587A CN110051587A CN201910376708.XA CN201910376708A CN110051587A CN 110051587 A CN110051587 A CN 110051587A CN 201910376708 A CN201910376708 A CN 201910376708A CN 110051587 A CN110051587 A CN 110051587A
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- sodium hyaluronate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention discloses a kind of anti-apolexis composition containing a variety of sodium hyaluronates; by weight percentage; including following raw material: butanediol 1~10%; hydrolyze hyaluronic acid 1~5%; acetylation Sodium Hyaluronate 1~5%; Sodium Hyaluronate 0.1~5%; Sodium Hyaluronate cross-linked polymer 0.1~5%; hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.1~5%, oligopeptides -1 0.1~1%, Radix Cynanchi Atrati extract 0.01~1%; PEG-60 rilanit special 0.1~0.5%; parahydroxyacet-ophenone 0.1~0.5%, decoyl hydroximic acid 0.1~1%, deionized water adds to 100%.The present invention extends the function of product, can replenishing water and preserving moisture but also maintenance soothe the skin；Simultaneously because this is water solubility at subassembly, so not limited by product forms, aqua, lotion, cream, essence etc. can be made an addition to.
Description
Technical field
The present invention relates to a kind of preparation method and application of anti-apolexis composition containing a variety of sodium hyaluronates, belong to cosmetics neck
Domain.
Background technique
Liking to be beautiful is the person's character of people, and beautiful face is often that water moistens, is bright, having no time, full of elasticity, however as the age
Increase, the increase of pressure, air pollution continues, and the skin of people gradually appears water shortage, and pore is coarse, dim heavy bellding, lacks
The problems such as elasticity, wrinkle microgroove, it is desirable to keep the beauty of skin, skin is badly in need of being protected.
Existing skin care item are many kinds of, Various Functions, such as " a kind of whitening and moisturizing Moisturizer " (application No. is
201810729625.X), it discloses the skin care item to be prepared by the raw material of following parts by weight: 2-15 parts of glycerol, arbutin 2-5
Part, 1-2 parts of shea butter, 3~5 parts of Fructificatio Tricholomatis Matsutakis extract, 5-10 parts of pearl powder, 2-5 parts of mealy potato, 1-3 parts of citric acid, Tibet is red
Flower 0.5-2 parts, 3-8 parts of beeswax, 3-8 parts of grape seed extract, 3-7 parts of persimmon leaf tartaric acid, 3-7 parts of asparagus juice, rose extract
2-5 parts, 3-8 parts of ginseng, 30-55 parts of pure water.
Have again patent " a kind of deep water supplement moisture-keeping composition and its application in skin care item " (application No. is
201810685938.X), by the weight ratio meter for accounting for skin care item, which is by 0.01~10% Tujue
Rose water, 0.01~8% Flos Rosae Rugosae extract, 0.01~6% torsion thorn Cactus Pedicel extract, 0.01~5% gold
Small cup flower extract, 0.01~2% Sodium Hyaluronate, 0.02~6% lecithin, 0.01~5% trehalose, 0.001~
1% ceramide composition.
Currently used maintenance product effect is not ideal enough, and purpose is not clear enough, so people are highly desirable to effect
Clear, effect multiplicity, safely, have no adverse reaction, and the product with moisturizing, moisturizing, maintenance, effect of releiving.
Summary of the invention
In view of the above existing problems in the prior art, the present invention provides a kind of anti-apolexis compositions containing a variety of sodium hyaluronates
Preparation method and application, can replenishing water and preserving moisture but also maintenance soothe the skin.
To achieve the goals above, a kind of anti-apolexis composition containing a variety of sodium hyaluronates that the present invention uses, by weight hundred
Divide than meter, including following raw material: butanediol 1~10%, hydrolysis hyaluronic acid 1~5%, acetylation Sodium Hyaluronate 1~5%,
Sodium Hyaluronate 0.1~5%, Sodium Hyaluronate cross-linked polymer 0.1~5%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.1
~5%, oligopeptides -1 0.1~1%, Radix Cynanchi Atrati extract 0.01~1%, PEG-60 rilanit special 0.1~0.5%, para hydroxybenzene
Ethyl ketone 0.1~0.5%, decoyl hydroximic acid 0.1~1%, deionized water adds to 100%.
As an improvement, by weight percentage, including following raw material: butanediol 1~7% hydrolyzes hyaluronic acid 1~3%,
Acetylation Sodium Hyaluronate 1~3%, Sodium Hyaluronate 0.1~3%, Sodium Hyaluronate cross-linked polymer 0.1~3%, hydroxypropyl
Trimethyl ammonium chloride hyaluronic acid 0.1~3%, oligopeptides -1 0.1~1%, Radix Cynanchi Atrati extract 0.01~1%, PEG-60 hydrogenate castor
Sesame oil 0.1~0.5%, parahydroxyacet-ophenone 0.1~0.3%, decoyl hydroximic acid 0.1~0.8%, deionized water adds to 100%.
As an improvement, by weight percentage, including following raw material: butanediol 6.3% hydrolyzes hyaluronic acid 2%, acetyl
Change Sodium Hyaluronate 2%, Sodium Hyaluronate 1%, Sodium Hyaluronate cross-linked polymer 1%, hydroxypropyl-trimethyl ammonium chloride is transparent
Matter acid 1%, oligopeptides -1 0.5%, Radix Cynanchi Atrati extract 0.05%, PEG-60 rilanit special 0.1%, parahydroxyacet-ophenone
0.3%, decoyl hydroximic acid 0.8%, deionized water adds to 100%.
In addition, the present invention also provides the preparation methods of the anti-apolexis composition containing a variety of sodium hyaluronates described in one kind, including
Following steps:
1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
2) water, butanediol, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, hydrolysis hyaluronic acid, second are added in water phase pot
Acylated Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, parahydroxyacet-ophenone, stirring be warming up to 85 DEG C~
It 95 DEG C, stirs, keeps the temperature 25~35 minutes；
3) it when being cooled to 35~50 DEG C, sequentially adds oligopeptides -1, extracted with the radix cynanchi atrati that part water and butanediol are pre-mixed
Object, PEG-60 rilanit special, decoyl hydroximic acid, stir；
4) 35~40 DEG C are cooled to, filtering, is stood discharging；
5) after the assay was approved, filling, packaging, coding, storage.
In addition, the application the present invention also provides a kind of anti-apolexis composition as additive in cosmetics.
As an improvement, the cosmetics are any one of lotion, cream, essence.
Compared with prior art, the present invention by formula addition hydrolysis hyaluronic acid, acetylation Sodium Hyaluronate, thoroughly
Bright matter acid sodium, Sodium Hyaluronate cross-linked polymer, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, oligopeptides -1, radix cynanchi atrati
(CYNANCHUM ATRATUM) extract at subassembly, extend the function of product, can replenishing water and preserving moisture but also maintenance releive
Skin；Simultaneously because this is water solubility at subassembly, so not limited by product forms, aqua, lotion, cream can be made an addition to
Frost, essence etc..
Specific embodiment
In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention is carried out below further detailed
It describes in detail bright.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, it is not limited to this hair
Bright range.
Unless otherwise defined, all technical terms and scientific terms used herein are led with technology of the invention is belonged to
The normally understood meaning of the technical staff in domain is identical, and term as used herein in the specification of the present invention is intended merely to retouch
State the purpose of specific embodiment, it is not intended that in the limitation present invention.
A kind of anti-apolexis composition containing a variety of sodium hyaluronates, by weight percentage, including following raw material: butanediol 1~
10%, hydrolyze hyaluronic acid 1~5%, acetylation Sodium Hyaluronate 1~5%, Sodium Hyaluronate 0.1~5%, Sodium Hyaluronate
Cross-linked polymer 0.1~5%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.1~5%, oligopeptides -1 0.1~1%, radix cynanchi atrati mentions
Take object 0.01~1%, PEG-60 rilanit special 0.1~0.5%, parahydroxyacet-ophenone 0.1~0.5%, decoyl hydroximic acid 0.1
~1%, deionized water adds to 100%.
The dosage of above-mentioned each component and its effect such as the following table 1 in the skin care item.
The dosage of each component of the present invention of table 1 and its effect in the skin care item
Wherein, hydrolysis hyaluronic acid, which belongs to ultra-low molecular hyaluronic acid, can penetrate into corium, have mild dilation capillary,
Increase blood circulation, improve intermediate supersession, promote skin-nourishing absorption, has the function of stronger wrinkle-chasing, skin can be increased
Elasticity, delay skin aging.The proliferation and differentiation, scavenging activated oxygen that can also promote epidermal cell, can prevent and repair skin
Damage.Hydrolysis hyaluronic acid permeability is strong, and can penetrate to the skin cuticula, and nutrition reparation work is directly generated to keratoderma
With.Moisture retention is only second to ceramide, is 6-7 times of common molecular HA moisture retention.The HA of common molecular forms a film in skin surface,
But it is easy to clean fall, advantage is that skin sense is good.Hydrolysis hyaluronic acid can be combined in skin surface with Skin Cell, be not easy to clear
It washes off, very strong moisturizing support and protective effect is formed to skin.It hydrolyzes hyaluronic acid and improves skin moisture content.With macromolecular
HA is used cooperatively, can be synergistic, obtains better moistening effect.
Acetylation Sodium Hyaluronate (Sodium Acetylated Hyaluronate) is by natural moisturizing factor hyalomitome
Sour sodium (HA) obtains through acetylization reaction.The introducing of acetyl group brings lipophilicity to HA, enhance HA to the compatibility of skin and
Adsorptivity improves the performance of keeping humidity of HA, and acetylation Sodium Hyaluronate has high suction " skin " property, both can reduce water in skin surface
Divide evaporation, increase internal moisture accumulation, and epidermis hydration cutin-softening layer can be permeated, it is inside and outside to act on simultaneously, to play dual
Moisture-keeping efficacy improves dry skin, roughened state, enables skin softness elastic；Double moisturizing power, the moisture in cuticula combine
Ability improves skin moisture content；Skin barrier is repaired, epidermal cell proliferation is promoted, reduces skin water loss amount, increases skin
Effect of skin elasticity.Acetylation Sodium Hyaluronate has efficient moisture-retention, reparation skin barrier, increase skin elasticity and other effects, skin
Sense does not stick clearly greasy.
Sodium Hyaluronate is also known as sodium hyaluronate sodium, belongs to skin conditioner, is a kind of acid mucopolysaccharide, is naturally present in cornea
Pi Zhong can absorb itself 1000 times of moisture of weight, is lost by retaining moisture of skin, prevention moisture through epidermis with reaching, with
And the barrier reparation when skin is damaged, it enables skin not feel drying after, increases gloss, it can improve skin
Nutrition and Metabolism, make skin it is soft, it is smooth, go wrinkle, increase elasticity, prevent aging, be good Transdermal absorption again while moisturizing
Promotor.It is used cooperatively with other nutritional ingredients, the more preferable effect for promoting nutrient absorption can be played.
Sodium Hyaluronate cross-linked polymer is the new production that natural moisturizing factor hyaluronic acid (HA) develops to super high molecular weight
Object, skin sense is soft and smooth and high resilience.Stereoscan photograph shows that Sodium Hyaluronate cross-linked polymer is fine and close 3 D stereo net
Shape structure, uniform fold form one layer of breathable films in skin surface, can reinforce skin barrier function, reduce inside skin
Moisture evaporation, while resisting invasion of the external environments such as ultraviolet light, dust, haze to skin.In addition, Sodium Hyaluronate crosslinking is poly-
Closing object has better hyaluronidase tolerance, and compared with common HA, Sodium Hyaluronate cross-linked polymer is in skin surface shape
At protective film it is more stable, act on it is more longlasting.Sodium Hyaluronate cross-linked polymer has super high molecular weight, HA molecule local height
Aggregation folds, and can be formed " miniature tank " in conjunction with more hydrones, continue moisturizing.Clinical test discovery is more than half
Several Sodium Hyaluronate cross-linked polymer frost triers indicates that compared with the control group, Sodium Hyaluronate cross-linked polymer skin care is made
With significant, skin more moistens smooth, high resilience.Sodium Hyaluronate cross-linked polymer --- moisturizing, protection settle at one go, fit
Exploitation and use for type products such as moisturizing, anti-aging, anti-haze antipollutions.
Hydroxypropyl-trimethyl ammonium chloride hyaluronic acid is obtained after the sufficiently complex reaction of appropriate cation by Sodium Hyaluronate
The high-affinity Sodium Hyaluronate arrived is a kind of Novel conditioning moisturizer.Hydroxypropyl-trimethyl ammonium chloride hyaluronic acid height parent
It is mutually cooperateed with two kinds of high molecular polymers, improves hyaluronic acid to the compatibility of skin, more resistant to flushing.Hydroxyproyl Trimethyl
Ammonium chloride hyaluronic acid can alleviate stimulation of the surfactant to skin, and skin sense is smooth.Conducive to permeating and absorbing, eliminate freely
Base directly facilitates the maintenance of Skin Cell, improves skin barrier function, maintains the metabolism environment of balance.
Oligopeptides -1 (OLIGOPEPTIDE-1) has been put on record CFDA Listed in Bureau of Drugs Supervision, meets Chinese law and regulations.Oligopeptides -1 exists
Nineteen sixty-eight is found by Pickar and Pilgeram, is a kind of small-molecular peptides being made of 3 amino acid, is ECM protein, I type glue
Amino acid sequence in former albumen can activate and adjust skin by the albumen enzyme r e lease of wound location, these molecules of release
Repair process.Oligopeptides -1, which has, promotes promoting epidermization, stimulates extracellular matrix (ECM), I-type collagen, III collagen type
It generates, repairs skin barrier, improve red capillary, anti-ageing tender skin, the function of bright color.
Radix cynanchi atrati (CYNANCHUM ATRATUM) extract is the natural anti-irritant ingredient from the Nature, and tradition application is upper,
Radix cynanchi atrati can with fall fire, therefore can be in typhoid fever later period or postpartum consumption energy and blood of human body and body fluid and internal low fever does not weaken and controls
More fever after physical fatigue symptom, the cough due to caused by waste heat, diuresis, useless fellow, malignant sore, sphagitis, on the wound stung by snake
It uses.In skin care, in the research that the growth with inflammatory reaction correlation factor hinders effect, radix cynanchi atrati (CYNANCHUM
ATRATUM) extract has apparent inhibitory effect, i.e. radix cynanchi atrati (CYNANCHUM to the growth of IL-1 (Interleukin-1)
ATRATUM) extract has good antiphlogistic effects, can loosen nervous and sensibility flesh of releiving, releive because of dyeing and perm, ultraviolet spoke
Sensitive scalp skin caused by factors, the anti-irritant, anti-inflammatory such as penetrate；Promote wound healing, alleviates the pressure flesh of city life
Skin.The manufacturer of Radix Cynanchi Atrati extract is RADIANT.
As an improvement, by weight percentage, including following raw material: butanediol 1~7% hydrolyzes hyaluronic acid 1~3%,
Acetylation Sodium Hyaluronate 1~3%, Sodium Hyaluronate 0.1~3%, Sodium Hyaluronate cross-linked polymer 0.1~3%, hydroxypropyl
Trimethyl ammonium chloride hyaluronic acid 0.1~3%, oligopeptides -1 0.1~1%, Radix Cynanchi Atrati extract 0.01~1%, PEG-60 hydrogenate castor
Sesame oil 0.1~0.5%, parahydroxyacet-ophenone 0.1~0.3%, decoyl hydroximic acid 0.1~0.8%, deionized water adds to 100%.
As an improvement, by weight percentage, including following raw material: butanediol 6.3% hydrolyzes hyaluronic acid 2%, acetyl
Change Sodium Hyaluronate 2%, Sodium Hyaluronate 1%, Sodium Hyaluronate cross-linked polymer 1%, hydroxypropyl-trimethyl ammonium chloride is transparent
Matter acid 1%, oligopeptides -1 0.5%, Radix Cynanchi Atrati extract 0.05%, PEG-60 rilanit special 0.1%, parahydroxyacet-ophenone
0.3%, decoyl hydroximic acid 0.8%, deionized water adds to 100%.
In addition, the present invention also provides a kind of preparation methods of anti-apolexis composition, comprising the following steps:
1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
2) water, butanediol, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, hydrolysis hyaluronic acid, second are added in water phase pot
Acylated Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, parahydroxyacet-ophenone, stirring be warming up to 85 DEG C~
It 95 DEG C, stirs, keeps the temperature 25~35 minutes；
3) it when being cooled to 35~50 DEG C, sequentially adds oligopeptides -1, extracted with the radix cynanchi atrati that part water and butanediol are pre-mixed
Object, PEG-60 rilanit special, decoyl hydroximic acid, stir；
4) 35~40 DEG C are cooled to, filtering, is stood discharging；
5) after the assay was approved, filling, packaging, coding, storage.
In addition, the application the present invention also provides a kind of anti-apolexis composition as additive in cosmetics.
As an improvement, the cosmetics are any one of lotion, cream, essence.
Embodiment 1
A kind of anti-apolexis composition containing a variety of sodium hyaluronates, by weight percentage, including following raw material: butanediol
10%, hydrolyze hyaluronic acid 5%, acetylation Sodium Hyaluronate 5%, Sodium Hyaluronate 5%, Sodium Hyaluronate cross-linked polymer
5%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 5%, oligopeptides -1 1%, Radix Cynanchi Atrati extract 1% (goes with 0.375% in advance
Ionized water, 0.3% butanediol mixing), PEG-60 rilanit special 0.5%, parahydroxyacet-ophenone 0.5%, decoyl hydroximic acid
1%, finally 100% is added to deionized water；
The preparation method of the anti-apolexis composition, comprising the following steps:
1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
2) water, butanediol, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, hydrolysis hyaluronic acid, second are added in water phase pot
Acylated Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, parahydroxyacet-ophenone, stirring are warming up to 95 DEG C, fill
Divide and stir evenly, keeps the temperature 25 minutes；
3) when being cooled to 50 DEG C, oligopeptides -1, preparatory with 0.375% deionized water and 0.3% butanediol is sequentially added
Mixed Radix Cynanchi Atrati extract, PEG-60 rilanit special, decoyl hydroximic acid, stir；
4) 40 DEG C are cooled to, filtering, is stood discharging；
5) after the assay was approved, filling, packaging, coding, storage.
Embodiment 2
A kind of anti-apolexis composition containing a variety of sodium hyaluronates, by weight percentage, including following raw material: butanediol 1%,
Hydrolyze hyaluronic acid 1%, acetylation Sodium Hyaluronate 1%, Sodium Hyaluronate 0.1%, Sodium Hyaluronate cross-linked polymer
0.1%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.1%, oligopeptides -1 0.1%, (the use in advance of Radix Cynanchi Atrati extract 0.01%
0.375% deionized water, 0.3% butanediol mixing), PEG-60 rilanit special 0.1%, parahydroxyacet-ophenone 0.1%,
Decoyl hydroximic acid 0.1%, deionized water adds to 100%；
The preparation method of the anti-apolexis composition, comprising the following steps:
1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
2) remaining water, butanediol, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, hydrolysis hyalomitome are added in water phase pot
Acid, acetylation Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, parahydroxyacet-ophenone, stirring are warming up to 85
DEG C, it stirs, keeps the temperature 35 minutes；
3) when being cooled to 45 DEG C, oligopeptides -1, preparatory with 0.375% deionized water and 0.3% butanediol is sequentially added
Mixed Radix Cynanchi Atrati extract, PEG-60 rilanit special, decoyl hydroximic acid, stir；
4) 40 DEG C are cooled to, filtering, is stood discharging；
5) after the assay was approved, filling, packaging, coding, storage.
Embodiment 3
A kind of anti-apolexis composition containing a variety of sodium hyaluronates, by weight percentage, including following raw material: butanediol 6%,
Hydrolyze hyaluronic acid 2%, acetylation Sodium Hyaluronate 2%, Sodium Hyaluronate 1%, Sodium Hyaluronate cross-linked polymer 1%, hydroxyl
Hydroxypropyltrimonium chloride hyaluronic acid 1%, oligopeptides -1 0.5%, Radix Cynanchi Atrati extract 0.05% (in advance with 0.375% go from
Sub- water, 0.3% butanediol mixing), PEG-60 rilanit special 0.1%, parahydroxyacet-ophenone 0.3%, decoyl hydroximic acid
0.8%, deionized water adds to 100%；
The preparation method of the anti-apolexis composition, comprising the following steps:
1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
2) water, butanediol, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, hydrolysis hyaluronic acid, second are added in water phase pot
Acylated Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, parahydroxyacet-ophenone, stirring are warming up to 90 DEG C, fill
Divide and stir evenly, keeps the temperature 30 minutes；
3) when being cooled to 45 DEG C, oligopeptides -1, preparatory with 0.375% deionized water and 0.3% butanediol is sequentially added
Mixed Radix Cynanchi Atrati extract, PEG-60 rilanit special, decoyl hydroximic acid, stir；
4) 35 DEG C are cooled to, filtering, is stood discharging；
5) after the assay was approved, filling, packaging, coding, storage.
Specific dosage such as the following table 2 of the various embodiments described above, while using certain commercially available brand as reference examples.
The dosage of 2 various embodiments of the present invention of table
To it is above-mentioned prepare have the effect of moisturizing, moisturizing, maintenance, the skin care item for effect of releiving and certain commercially available brand into
Performing check comparison.
1. replenishing water and preserving moisture performance test
Female volunteers of 10 ages between 18~50 are looked for, in 20 DEG C, the indoor environment of relative humidity 50%, point
One 2 square centimeters of fixed area is drawn in forehead, using there is moisturizing above, moisturizing, maintenance, releive in fixed area
After the skin care item of effect and commercially available common skin care item, tested with Corneometer CM285 skin moisture detector, it is comprehensive to obtain
Humidity of skin delta data, test result is as follows table 3.
3 replenishing water and preserving moisture the performance test results of table
From the results shown in Table 3, make-up water percentage of the invention and moisturizing rate are relatively not added with hydrolysis hyaluronic acid, acetyl
Change Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, oligopeptides-
1, moisturizing and the moisturizing effect of the reference examples of radix cynanchi atrati (CYNANCHUM ATRATUM) extract combination ingredient and commercially available common skin care item
Fruit is significant.
2. impaired skin is helped to restore test
Female volunteers of 15 ages between 18~50 are looked for, in 20 DEG C, the indoor environment of relative humidity 50%, point
The fixed area that one 2 square centimeters are drawn in forehead, in fixed area with the immersion of 5%SDS lotion 2 hours to destroy skin,
Then using above with moisturizing, moisturizing, maintenance, the skin care item releived and commercially available common skin care item daily two in fixed area
It is secondary, continue fortnight, with the aquation of cutin measuring appliance measurement arm, the comprehensive skin hydration that obtains acts on delta data (water
Close that threshold is higher to illustrate that the skin that is destroyed must be better by maintenance), test result is as follows table 4.
Table 4 helps impaired skin to restore test result
| Sample | Before use | After 3 | After 7 days | After 14 days |
| Embodiment 1 | -12 | 7 | 10 | 14 |
| Embodiment 2 | -12 | 3 | 4 | 6 |
| Embodiment 3 | -10 | 5 | 7 | 10 |
| Reference examples | -9 | -7 | -4 | 1 |
| Commercially available common skin care item | -11 | -8 | -2 | 3 |
From the results shown in Table 4, skin barrier maintenance effect of the invention is relatively not added with hydrolysis hyaluronic acid, second
Acylated Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, widow
The skin barrier of peptide -1, the reference examples of radix cynanchi atrati (CYNANCHUM ATRATUM) extract combination ingredient and commercially available common skin care item
Maintenance significant effect.
3. lactic acid shouting pain is tested
Pre-selection 25 are used as lactic acid sensitive subjects, at 20 DEG C, the interior of relative humidity 50% in tested volunteer (24 to 67 years old)
In environment, one 2 square centimeters of fixed area is drawn in forehead respectively, in fixed area using there is moisturizing above, moisturizing, repair
It protects, the skin care item for effect of releiving and commercially available common skin care item, study subject use once daily, continuous use 7 days, during test
Without using other any products.It uses in fixed area above with moisturizing, moisturizing, maintenance, the skin care item for effect of releiving and city
It sells common skin care item 1h and applies 10% lactic acid solution, its itch effect of testing and assessing after 7 days at fixed area again.
In the case where dermatologist supervises, minute (no intensity) marks tingling sensation and continues 5 points subject from 0 to 3 per minute
Clock.If being better than 3 in the 3rd and the 5th minute mark value, then it is assumed that subject is shouting pain person.As a result as shown in table 5 below.
5 lactic acid shouting pain test result of table
As can be seen from Table 5, the present invention effect of releiving, be relatively not added with hydrolysis hyaluronic acid, acetylation Sodium Hyaluronate, thoroughly
Bright matter acid sodium, Sodium Hyaluronate cross-linked polymer, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, oligopeptides -1, radix cynanchi atrati
The reference examples of (CYNANCHUM ATRATUM) extract combination ingredient and the significant effect of releiving of commercially available common skin care item.Big portion
Point subject perception is to effect and the feeling of pain of quickly releiving, sense of discomfort, erythema, the decrease of itch intensity and burning heat sensation.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (6)
1. a kind of anti-apolexis composition containing a variety of sodium hyaluronates, which is characterized in that by weight percentage, including following raw material:
Butanediol 1~10%, hydrolysis hyaluronic acid 1~5%, acetylation Sodium Hyaluronate 1~5%, Sodium Hyaluronate 0.1~5%, thoroughly
Bright matter acid sodium cross-linked polymer 0.1~5%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.1~5%, oligopeptides -1 0.1~
1%, Radix Cynanchi Atrati extract 0.01~1%, PEG-60 rilanit special 0.1~0.5%, parahydroxyacet-ophenone 0.1~0.5% is pungent
Acyl hydroximic acid 0.1~1%, deionized water adds to 100%.
2. a kind of anti-apolexis composition containing a variety of sodium hyaluronates according to claim 1, which is characterized in that percentage by weight
Than meter, including following raw material: butanediol 1~7% hydrolyzes hyaluronic acid 1~3%, and acetylation Sodium Hyaluronate 1~3% is transparent
Matter acid sodium 0.1~3%, Sodium Hyaluronate cross-linked polymer 0.1~3%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 0.1~
3%, oligopeptides -1 0.1~1%, Radix Cynanchi Atrati extract 0.01~1%, PEG-60 rilanit special 0.1~0.5%, para hydroxybenzene second
Ketone 0.1~0.3%, decoyl hydroximic acid 0.1~0.8%, deionized water adds to 100%.
3. a kind of anti-apolexis composition containing a variety of sodium hyaluronates according to claim 2, which is characterized in that percentage by weight
Than meter, including following raw material: butanediol 6.3% hydrolyzes hyaluronic acid 2%, acetylation Sodium Hyaluronate 2%, Sodium Hyaluronate
1%, Sodium Hyaluronate cross-linked polymer 1%, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid 1%, oligopeptides -1 0.5%, radix cynanchi atrati mentions
Object 0.05% is taken, PEG-60 rilanit special 0.1%, parahydroxyacet-ophenone 0.3%, decoyl hydroximic acid 0.8%, deionized water adds
To 100%.
4. a kind of preparation method of any one of claim 1-3 anti-apolexis composition, which is characterized in that including following step
It is rapid:
1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
2) water, butanediol, hydroxypropyl-trimethyl ammonium chloride hyaluronic acid, hydrolysis hyaluronic acid, acetylation are added in water phase pot
Sodium Hyaluronate, Sodium Hyaluronate, Sodium Hyaluronate cross-linked polymer, parahydroxyacet-ophenone, stirring are warming up to 85 DEG C~95 DEG C,
It stirs, keeps the temperature 25~35 minutes；
3) when being cooled to 35~50 DEG C, sequentially add oligopeptides -1, the Radix Cynanchi Atrati extract being pre-mixed with part water and butanediol,
PEG-60 rilanit special, decoyl hydroximic acid, stir；
4) 35~40 DEG C are cooled to, filtering, is stood discharging；
5) after the assay was approved, filling, packaging, coding, storage.
5. a kind of application of any one of claim 1-4 anti-apolexis composition as additive in cosmetics.
6. cosmetics according to claim 5, which is characterized in that the cosmetics are lotion, cream, any in essence
Kind.
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