CN112870098B - Composition containing acetylated sodium hyaluronate and having wrinkle removing effect and preparation method and application thereof - Google Patents
Composition containing acetylated sodium hyaluronate and having wrinkle removing effect and preparation method and application thereof Download PDFInfo
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- CN112870098B CN112870098B CN202110378610.5A CN202110378610A CN112870098B CN 112870098 B CN112870098 B CN 112870098B CN 202110378610 A CN202110378610 A CN 202110378610A CN 112870098 B CN112870098 B CN 112870098B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention provides a composition containing acetylated sodium hyaluronate and having a wrinkle removing effect, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The paint comprises the following components in parts by mass: 0.2 to 12 portions of hydroxyethyl urea, 0.2 to 5 portions of urea, 1 to 20 portions of butanediol, 2 to 10 portions of rhamnose, 0.5 to 2 portions of 1, 2-hexanediol, 25.2 to 88.5 portions of water, 0.05 to 0.8 portion of sodium hyaluronate, 5 to 15 portions of yeast fermentation product filtrate, 1 to 5 portions of acetylated sodium hyaluronate and 0.5 to 5 portions of turfgrass salt and horn grass extract. The hydroxyethyl urea is an excellent wrinkle removing agent, can provide a high-efficiency wrinkle removing effect for skin care products, and has the advantages of being natural, high in activity, easy to absorb and high in safety; the screening of the dosage relationship of the components shows obvious synergistic effect, can resist the loss of the skin, and further has the effects of regulating the biological rhythm of the skin, delaying the skin aging and improving the pigmentation.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition containing acetylated sodium hyaluronate and having a wrinkle removing effect, and a preparation method and application thereof.
Background
The skin is the largest organ covering the whole body surface, which is the protector of the internal organs and tissues of the human body, and is also the effect organ of the internal organs, spirit and the surrounding environment, which plays an important role in the health and beauty of the human body. The skin aging is a natural development rule, and factors influencing the skin aging mainly comprise endogenous factors and exogenous factors, wherein the endogenous factors comprise a genetic theory, a metabolite damage theory, a neuro-immune-endocrine dyscrasia theory and the like; extrinsic factors include photoaging, environmental pollution, and the like. The remarkable properties of skin aging are the appearance of wrinkles, skin laxity, skin roughness, loss of elasticity, pigmentation, etc. The facial skin wrinkles are formed by facial soft tissue aging and facial muscle movement, and various wrinkle removing means such as rejuvenation operation, soft tissue filling, chemical skin changing, laser, botulinum toxin injection and the like exist at present, so that the facial skin wrinkles have a certain treatment effect. However, most of them are invasive and may cause side effects such as pigmentation. Therefore, people are more expected to expect that cosmetics which are safe, mild and suitable for daily use can remove wrinkles.
At present, a large number of wrinkle-removing cosmetics sold in the market, such as Chinese patents CN111228208A, CN108904317A and CN106619326A, have the problem of poor wrinkle-removing effect.
Disclosure of Invention
In view of the above, the present invention aims to provide a composition containing acetylated sodium hyaluronate with wrinkle removing effect, and a preparation method and an application thereof. The composition provided by the invention has a good wrinkle-removing effect.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a composition containing acetylated sodium hyaluronate and having a wrinkle removing effect, which comprises the following components in parts by mass:
0.2 to 12 portions of hydroxyethyl urea,
0.2 to 5 portions of urea,
1 to 20 portions of butanediol,
2-10 parts of rhamnose, and the like,
0.5 to 2 portions of 1, 2-hexanediol,
25.2 to 88.5 portions of water,
0.05 to 0.8 portion of sodium hyaluronate,
5 to 15 parts of yeast fermentation product filtrate,
1 to 5 parts of acetylated sodium hyaluronate,
0.5 to 5 parts of turfgrass saline grass extract.
Preferably, the composition comprises the following components in parts by mass:
0.2 part of hydroxyethyl urea,
0.2 part of urea, namely, urea,
1 part of butanediol, namely preparing a reaction product,
2 parts of rhamnose, namely, 2 parts of rhamnose,
2 parts of 1, 2-hexanediol,
88.5 parts of water, namely,
0.05 part of sodium hyaluronate,
5 parts of yeast fermentation product filtrate,
1 part of acetylated sodium hyaluronate,
0.5 part of turfgrass salt common stonecrop herb extract.
Preferably, the composition comprises the following components in parts by mass:
12 parts of hydroxyethyl urea, namely 12 parts of hydroxyethyl urea,
5 parts of urea, namely 5 parts of urea,
20 parts of butanediol (butanediol),
10 parts of rhamnose, namely 10 parts of,
2 parts of 1, 2-hexanediol,
25.2 parts of water, namely,
0.8 part of sodium hyaluronate,
15 parts of yeast fermentation product filtrate,
5 parts of acetylated sodium hyaluronate,
5 parts of a turfgrass salt common stonecrop herb extract.
Preferably, the sodium hyaluronate has an average molecular weight of 4000 to 5000.
The invention also provides a preparation method of the composition containing the acetylated sodium hyaluronate and having the wrinkle removing effect, which comprises the following steps:
and mixing hydroxyethyl urea, butanediol, rhamnose, 1, 2-hexanediol, water, sodium hyaluronate, yeast fermentation product filtrate, acetylated sodium hyaluronate and a turfgrass horn extract to obtain the composition containing acetylated sodium hyaluronate and having the wrinkle removing effect.
Preferably, the mixing further comprises filtration through a 0.22 μm filter.
The invention also provides application of the composition containing the acetylated sodium hyaluronate and having the wrinkle removing effect in cosmetics, wherein the cosmetics are skin cream, facial cleanser, emulsion, wrinkle removing agent or skin lotion.
Preferably, the wrinkle removing agent contains acetylated sodium hyaluronate and has the wrinkle removing effect, and the mass percentage of the composition is 30-100%.
The invention provides a composition containing acetylated sodium hyaluronate and having a wrinkle removing effect, which comprises the following components in parts by mass: 0.2 to 12 portions of hydroxyethyl urea, 0.2 to 5 portions of urea, 1 to 20 portions of butanediol, 2 to 10 portions of rhamnose, 0.5 to 2 portions of 1, 2-hexanediol, 25.2 to 88.5 portions of water, 0.05 to 0.8 portion of sodium hyaluronate, 5 to 15 portions of yeast fermentation product filtrate, 1 to 5 portions of acetylated sodium hyaluronate and 0.5 to 5 portions of grass green salicornia extract.
Compared with the prior art, the invention has the following beneficial effects:
1. the hydroxyethyl urea is an excellent wrinkle removing agent, can provide a high-efficiency wrinkle removing effect for skin care products, and has the advantages of being natural, high in activity, easy to absorb and high in safety.
2. The screening of the dosage relation of the components shows obvious synergistic effect, can resist the loss of skin, and further has the effects of regulating the biological rhythm of the skin, delaying the skin aging and improving the pigmentation.
Furthermore, the water used in the invention is distilled water, and is obtained by three times of distillation, so that impurities in the water can be completely removed.
The invention also provides a preparation method of the composition containing the acetylated sodium hyaluronate and having the wrinkle removing effect, which comprises the following steps: and (2) mixing hydroxyethyl urea, butanediol, rhamnose, 1, 2-hexanediol, water, sodium hyaluronate, yeast fermentation product filtrate, acetylated sodium hyaluronate and a turfgrass horn extract to obtain the composition containing acetylated sodium hyaluronate and having the wrinkle removing effect. The preparation method provided by the invention is simple, convenient to operate and easy to realize industrial production.
Furthermore, the invention also comprises a filter membrane of 0.22 μm after mixing, which can completely remove impurities in the raw materials without affecting the wrinkle removing effect.
Detailed Description
The invention provides a composition containing acetylated sodium hyaluronate and having a wrinkle removing effect, which comprises the following components in parts by mass:
0.2 to 12 portions of hydroxyethyl urea,
0.2 to 5 portions of urea,
1 to 20 portions of butanediol,
2-10 parts of rhamnose, and the like,
0.5 to 2 portions of 1, 2-hexanediol,
25.2 to 88.5 portions of water,
0.05 to 0.8 portion of sodium hyaluronate,
5 to 15 parts of yeast fermentation product filtrate,
1 to 5 parts of acetylated sodium hyaluronate,
0.5 to 5 parts of turfgrass saline grass extract.
In the invention, the composition containing the acetylated sodium hyaluronate and having the wrinkle removing effect preferably comprises the following components in parts by mass:
0.2 part of hydroxyethyl urea, 0.2 part of urea, 1 part of butanediol, 2 parts of rhamnose, 2 parts of 1, 2-hexanediol, 88.5 parts of water, 0.05 part of sodium hyaluronate, 5 parts of yeast fermentation product filtrate, 1 part of acetylated sodium hyaluronate, and 0.5 part of carex glaucophyllus extract or
12 parts of hydroxyethyl urea, 5 parts of urea, 20 parts of butanediol, 10 parts of rhamnose, 2 parts of 1, 2-hexanediol, 25.2 parts of water, 0.8 part of sodium hyaluronate, 15 parts of yeast fermentation product filtrate, 5 parts of acetylated sodium hyaluronate and 5 parts of turfgrass salicornia extract.
In the present invention, unless otherwise specified, all the raw materials used are commercially available in the art.
In the present invention, the average molecular weight of the sodium hyaluronate is preferably 4000 to 5000.
In the present invention, the water is preferably distilled water, and the distilled water is preferably obtained by distilling water three times, namely triple distilled water.
In the present invention, the yeast fermentation product filtrate is preferably AREN BIO-SACCHARO of DNE in Korea.
In the present invention, the salt of grass greenThe extract of Salicornia HERBACEA (Salicornia HERBACEA) is preferably Pure of Korean Danding
In the present invention, the acetylated sodium hyaluronate is preferably purchased from Huaxi Biotechnology corporation.
The invention also provides a preparation method of the composition containing the acetylated sodium hyaluronate and having the wrinkle removing effect, which comprises the following steps:
and mixing hydroxyethyl urea, butanediol, rhamnose, 1, 2-hexanediol, water, sodium hyaluronate, yeast fermentation product filtrate, acetylated sodium hyaluronate and a turfgrass horn extract to obtain the composition containing acetylated sodium hyaluronate and having the wrinkle removing effect.
In the present invention, the mixing preferably further comprises filtration with a 0.22 μm filter.
The invention also provides application of the composition containing the acetylated sodium hyaluronate and having the wrinkle removing effect in cosmetics, wherein the cosmetics are skin cream, facial cleanser, emulsion, wrinkle removing agent or skin lotion.
In the invention, the wrinkle removing agent contains acetylated sodium hyaluronate and the mass percentage content of the wrinkle removing composition is preferably 30-100%.
In order to further illustrate the present invention, the following examples are provided to describe the wrinkle-removing composition containing sodium hyaluronate with acetylation and its preparation method and application in detail, but they should not be construed as limiting the scope of the present invention.
Examples 1 to 2
The dosage of each raw material is shown in Table 1, wherein the average molecular weight of sodium hyaluronate in Table 1 is 5000, water is triple distilled water, yeast fermentation product filtrate is AREN BIO-SACCHAROS of Korean DNE, and grass green Salicornia HERBACEA (SALICORNIA HERBACEA) extract is Pure of Korean Danding
Sodium acetylated hyaluronate was purchased from Huaxi Biotech Ltd.
TABLE 1 dosage of each raw material of examples 1-2 in parts by mass (unit: g)
Examples 1-2 a method for preparing a composition having wrinkle-removing effect containing acetylated sodium hyaluronate was as follows:
mixing hydroxyethyl urea, butanediol, rhamnose, 1, 2-hexanediol, water, sodium hyaluronate, yeast fermentation product filtrate, acetylated sodium hyaluronate and grass green salicornia extract, and filtering with 0.22 μm filter membrane to obtain the composition containing acetylated sodium hyaluronate and having wrinkle removing effect.
The foregoing is merely a preferred embodiment of the invention and is not intended to limit the invention in any manner. It should be noted that modifications and adaptations can be made by those skilled in the art without departing from the principle of the present invention, and should be considered as within the scope of the present invention.
Claims (5)
1. The composition containing acetylated sodium hyaluronate and having the wrinkle removing effect is characterized by comprising the following components in parts by mass:
0.2 part of hydroxyethyl urea,
0.2 part of urea, namely, urea,
1 part of butanediol, namely preparing a mixture of butanediol,
2 parts of rhamnose, namely 2 parts of rhamnose,
2 parts of 1, 2-hexanediol,
88.5 parts of water, namely,
0.05 part of sodium hyaluronate,
5 parts of yeast fermentation product filtrate,
1 part of acetylated sodium hyaluronate,
0.5 part of turfgrass salicornia extract;
or the composition comprises the following components in parts by mass:
12 parts of hydroxyethyl urea, namely 12 parts of hydroxyethyl urea,
5 parts of urea, namely 5 parts of urea,
20 parts of butanediol (butanediol),
10 parts of rhamnose, namely 10 parts of,
2 parts of 1, 2-hexanediol,
25.2 parts of water, namely,
0.8 part of sodium hyaluronate,
15 parts of yeast fermentation product filtrate,
5 parts of acetylated sodium hyaluronate,
5 parts of a turfgrass salicornia extract;
the sodium hyaluronate has an average molecular weight of 4000 to 5000.
2. The method for preparing the composition containing the acetylated sodium hyaluronate with the wrinkle removing effect according to claim 1 is characterized by comprising the following steps:
and (2) mixing hydroxyethyl urea, butanediol, rhamnose, 1, 2-hexanediol, water, sodium hyaluronate, yeast fermentation product filtrate, acetylated sodium hyaluronate and a turfgrass horn extract to obtain the composition containing acetylated sodium hyaluronate and having the wrinkle removing effect.
3. The method of claim 2, further comprising filtering with a 0.22 μm filter after said mixing.
4. The application of the composition containing the sodium hyaluronate with the wrinkle removing effect in cosmetics as claimed in claim 1, wherein the cosmetics are skin cream, facial cleanser, emulsion, wrinkle removing agent or skin lotion.
5. The use according to claim 4, characterized in that the wrinkle-removing agent contains acetylated sodium hyaluronate and has the wrinkle-removing efficacy, and the mass percentage of the wrinkle-removing composition is 30-100%.
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