KR20070043449A - Nano emulsion skin aging prevention cosmetics composition - Google Patents

Abstract

The present invention relates to a nanoemulsion anti-aging cosmetic composition used to keep human skin healthy, clean and beautiful, and to delay and prevent skin aging that occurs physiologically with age.

Organo germanium with a safe and effective amount of amino acids introduced,

As other optional ingredients, bases and / or additives which are known for external skin use as well as medically acceptable ingredients, such as cosmetic ingredients, include water, alcohols, oils, surfactants, preservatives, perfumes, pigments, etc. Moisturizer, Thickener, Water Soluble Polymer, Antioxidant, Chelating Agent, PH Adjuster, Foaming Agent (Pigment, UV Absorption, Scattering Agent, Powder), Vitamins, Amino Acids, Antimicrobial Agent, Seaweed Extract, Various Ingredients Expression of pharmacological activity,

By the expression of the role that the gold acetylide compound, which is an organometallic complex, further improves / promotes the movement of the active compound,

Since the active ingredients of the active compounds are quickly delivered deep into the skin, they not only exhibit excellent skin aging anti-wrinkle effect and transdermal absorption effect, but also exhibit excellent effects on long-term preservation, stability on skin use, and convenience of use. It is.

Such nanoemulsion skin anti-aging cosmetic composition of the present invention,

0.01 ~ 2wt%와,Organo germanium with safe and effective amounts of basic amino acids

0.01 to 2wt%,

Gold acetylide compound [AuC ₆ H ₁₃ O] is an organometallic complex 0.0001 ~ 0.01wt%,

Water, alcohols, oils, surfactants, preservatives, fragrances, pigments, moisturizers, thickeners, water-soluble polymers, antioxidants, chelating agents, pH adjusters, foaming agents (pigments, UV absorbers, scattering agents, Powder), vitamins, amino acids, antibacterial agents, seaweed extract, is prepared by mixing one or more selected from drugs.

Description

Nano emulsion skin aging prevention cosmetics composition

The present invention relates to a nanoemulsion anti-aging cosmetic composition used to keep human skin healthy, clean, beautiful, and to delay and prevent skin aging that appears physiologically with age.

Generally, theories explaining skin aging include the theory of mutagenesis of somatic cells, the error occurrence theory of gene replication, the gene program theory, the free radical theory, the autoimmune response theory, the accumulation of toxic substances, and the theory of transformation of dermal constituent proteins. have.

These theories are all involved in skin aging.

Among these, the alteration of dermal constitutive proteins is known to be a major cause of skin aging.

In general, as the skin ages, as the lipid composition and content of the lipid layer that functions as a skin barrier changes, its function decreases rapidly, resulting in a decrease in moisture content of the skin, drying of the skin, and causing various skin lesions.

In addition, the increase in the amount of ultraviolet rays, air pollution and excessive fatigue and stress of modern people produces highly reactive free radicals, free radicals and peroxides.

The skin is affected by these things, and biological components (proteins, hexane, membrane lipids, etc.) are oxidatively denatured to act as a major cause of skin aging.

Especially, collagen, elastin, proteoylycans, laminin and fibronectin, which make up the connective tissue, are oxidized and lose their function. Loss of wrinkles and excessive formation of wrinkles is changing to aged skin.

As a result, skin aging phenomena such as loss of elasticity of the skin, wrinkle formation and skin wrinkles are caused by inhomogeneity of cells, loss of elastin, destruction of collagen, reduction and delay of collagen synthesis.

Therefore, skin aging occurs in the skin epidermis, but rather in the dermis.

The dermis is a connective tissue that contains epidermal appendages originating from nerves, blood vessels, and epidermis.

The connective tissue of the dermis is composed of collagen fibers, elastic fibers, and a ground substance with no particular shape, all of which are made by fibroblasts.

Collagen collagen is the main component of the dermis and accounts for 75% of the dry weight of the skin.

Collagen molecules have the property of cross-linking the rich side, rather than the end-to-end between the molecules makes collagen with tension along with the amino acid structure.

Elastic fibers make up 3% of the dry weight of the dermis, and the main function is to provide elasticity to the skin so that the skin deformed by the applied force returns to its original appearance.

Mature elastic fibers are made up of about 90% of elastin, an amorphous insoluble protein, and the rest are composed of microfiber proteins.

On the other hand, elastin is broken down by elastase, which causes skin elasticity to decrease.

The present invention has been made to solve the occurrence of skin aging phenomenon, such as loss of elasticity of the skin, skin wrinkles formed by the above-described causes,

By preparing a nano-emulsion anti-aging cosmetic composition which provides not only an excellent skin aging anti-wrinkle effect and transdermal absorption efficiency, but also an effect of long-term storage stability, skin stability and ease of use,

The purpose of the present invention is to keep the skin of people using the product containing the composition healthy, clean and beautiful, and to delay and prevent skin aging that occurs physiologically with age.

The present invention for achieving the above object,

과,Organo germanium with safe and effective amounts of basic amino acids

and,

Gold acetylide compound [AuC ₆ H ₁₃ O] which is an organometallic complex,

The present invention relates to a nanoemulsion anti-aging cosmetic composition prepared by containing a known medically acceptable skin externally acceptable additive and solvent in a range that does not impair the effects of the present invention as an optional ingredient.

Hereinafter, an organic germanium to which the basic amino acid used in the nanoemulsion skin anti-aging cosmetic composition of the present invention is introduced, an gold metal acetylide compound which is an organometallic complex, and an additive and a solvent that are externally acceptable for medical use as an optional ingredient mixed with them It will be described in more detail with respect to.

First, the organic germanium into which the basic amino acid is introduced will be described.

The organic germanium compound is generally excellent in characteristics as Biological Response Modifiers (BRMs), that is, biological response modifiers, and has an interferon organic activity, activation of microphages or NK cells, or anti-tumor activity, as described in many literatures. In addition, since the compound exhibits desirable pharmacological activity, such as inhibition of enkephalin degrading enzyme and improvement of calcium metabolism, it is used as a useful medicine as well as a compound having low toxicity.

However, biscarboxy ethyl germanium seski oxad [GeCH ₂ CH ₂ COOH) ₂ O ₃ ] generally has low solubility in water and hardly dissolves in a conventional organic solvent, and thus has difficulty in use.

In the present invention, a basic amino acid is used as the compound having a basic group, and examples of the basic amino acid include L-racin, L-arginine, and L-hisridine. In this case, the organic germanium compound and the basic amino acid and May combine with the carbonyl group COOH of the organic germanium and the amino group or the amino group of the basic amino acid.

Organo germanium containing the basic amino acid obtained in the present invention

의 염은 무기염기과의 염과는 달리 결정성에 있어서 우수하며 물에 대한 용해성이 크고 3 ~ 7%의 고농도의 액제로 사용할 수 가 있다.

Unlike salts with inorganic bases, the salt is excellent in crystallinity and has high solubility in water and can be used as a high concentration solution of 3 to 7%.

인 화학적으로 표시되는 화합물의 총칭이고 생체의 필수 구성성분으로서, 생명현상이 보이는 모든 생물계에 존재한다.Also, amino acids are basically

Phosphorus is a generic term for chemically represented compounds and is an essential component of living organisms and is present in all living systems where life is visible.

The importance of amino acids is not only that they form proteins by binding amino acids, but also that amino acids are metabolized in various ways in vivo, acting as "precursors" of other substances important to the living body.

To date, the effectiveness of organo germanium has been studied by various researchers, and there are many patents and research data on its effects. Examples of the organo germanium include anti-acne and therapeutic effects, antioxidant activity showing radical scavenging ability, UV damage protection effect, It has been reported to soften the skin, improve abnormal pigmentation, and treat atopic skin diseases. (JP63183570, JP62111908, US4229468, US4889715, US4623667, KASai Miracle cure, Organic Germanium, Japan Publications Inc ISBN 0-87040-1, 1980)

In view of this efficacy, organic germanium having a basic amino acid introduced is considered to be useful for anti-aging effects.

The nanoemulsion anti-aging cosmetic composition of the present invention preferably contains organic germanium having a basic amino acid introduced to 0.01 wt% to 2 wt% based on the weight of the composition.

This time, the gold acetylide compound will be described.

The nanoemulsion anti-aging cosmetic composition of the present invention contains a gold acetylide compound as a noble metal catalyst.

This improves the transport of the active compound to improve the transfer of components of the active compound to the hair follicles. The organometallic complex of the present invention is represented by the general formula M (-C≡CR) n (where M is a metal atom and n is a metal atom The valence number of n, R is a metal acetylide compound represented as a C1-8 hydrocarbon group containing or not containing an oxygen atom.

In addition, n is a noble metal atom, and R is a metal acetylide compound which is an aliphatic hydrocarbon which contains as a hydroxyl group when it contains oxygen.

Metal salts used in the present invention include metal salts selected from the group consisting of Au and platinum groups (Ru, Rh, Pd, Os, Ir, Pt).

The metal salt is a concept including a metal acrylate and a salt that does not cause abnormalities on the skin and includes a metal acid and a metal salt.

In addition, examples of the acetylene derivative included in the present invention include 2-propyn-1-ol, 1-butyn-3-ol, 3-methyl-1-butyl-3-ol, 3-methyl-1-pentin-3 -Ol, 1-hexane, 3.5-dimethyl-1-hexan-3-ol, 1-ethynyl-1-cyclo nucleic acidol and the like.

In the case of reducing the metal atoms in the metal salt, sulfite is used as the reducing agent.

On the other hand, an alkali salt of acetic acid is introduced as a substitution accelerator which accelerates the dehydration reaction of the metal atom in the metal salt or the acetylene derivative in the reduced metal atom and binds the metal atom to this part.

The case of gold (Au) is illustrated by the reaction formula at the time of reducing the metal atom in a metal salt.

As the metal salt, chloroacetic acid, an acetylene derivative, sodium acetate as a substitution promoter, and sodium sulfite as a reducing agent are introduced.

HAuCl ₄ + Na ₂ SO ₃ + H-C≡C-R + 4CH ₃ COONa + H ₂ O

→ Au-C≡C-R + 4NaCl + 4CH ₃ COOH + Na ₂ SO ₄

That is, Au≡C (OH) (CH ₃ ) (CH ₂ CH (CH ₃ ) ₂ ), and a gold acetylide compound of AuC ₆ H ₁₃ O is used as the composition formula.

The nanoemulsion anti-aging cosmetic composition of the present invention preferably contains 0.0001 to 0.01 wt% of a gold acetylide compound based on the weight of the composition.

This time, the additives and solvents that are medically acceptable for external skin as optional ingredients will be described in more detail.

Known medically acceptable bases and / or additives, such as cosmetic ingredients, include water, alcohols, oils, surfactants, preservatives, flavorings, pigments, humectants, thickeners, and water-soluble agents within the scope of not impairing the effects of the present invention. Polymers, antioxidants, chelating agents, PH modifiers, blowing agents (pigments, ultraviolet absorbers, scattering agents, powders), vitamins, amino acids, antibacterial agents, seaweed extracts, various drugs, additives and the like can be blended.

Specifically, as the oil,

Vegetable oils such as macadamia nut oil, pajama oil, olive oil, cacao oil, camellia oil, palm oil, wax, jojoba oil, grape seed oil, avocado oil,

Animal fats and oils such as mink oil and egg yolk oil,

Waxes such as beeswax, spermatozoon, lanolin, carnava wax and candelilla wax;

Hydrocarbons such as liquid paraffin, squalene, microcrystalline wax, selesin wax, paraffin wax, petrolatum,

Natural and synthetic fatty acids such as capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid, lauric acid, myristic acid, oleic acid, isostearic acid,

Natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol, capryl alcohol, myristyl alcohol, cetyl alcohol and cholesterol,

Esters such as isopropyl myristate, isopropyl palmitate, octylate dodecyl, octylate dodecyl oleate, and cholesterol oleate.

As said surfactant,

Sorbitan monolaurate, sorbitan monopalmitate, sorbitan sorbate, sesuccioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxetylene sorbitan monostearate, polyethylene glycol monooleate, Nonionic activators such as polyethylene glycol alkylates, polyoxyethylene alkyl ethers, polyglycol diethers, lauroyl diethanol amides, fatty acids, isopropanol amides, maltitol hydroxy fatty acid ethers, alkylated polysaccharides, alkyl glucosides, and sugar esters;

Lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerol monostearate, polyglycerol alkylate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene Nonionic surfactants such as cetyl ether, polyoxyethylenated sterol, polyoxyethylenated lanolin, polyoxyethylenated beeswax, polyoxyethylene hardened castor oil,

Sodium stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl phosphate, triethanolamine palmitate, sodium polyoxyethylene lauryl phosphate, sodium N-acyl glutamate, sodium palmitate, sodium laurate, lauryl sulfate Anionic surfactants such as potassium, alkyl sulfate triethanol amine ether, linear dodecylbenzene sulfuric acid, polyoxyethylene-cured castor oil maleic acid, acylmethyl tauric acid,

Cationic surfactants such as stearyl dimethylbenzyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, benzalkonium chloride and laurylamine oxide, and

Amphoteric surfactants, such as the alkylaminoethylglycine chloride and lecithin, etc. can be illustrated.

As the preservative,

Benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, 2,4,4-trichloro-2-hydroxydiphenylether, 3,3,4-trichlorocarbanilide, chloride Benzalkonium, hinokithiol, resorcin, ethanol, etc. can be illustrated.

The moisturizing agent,

Polyhydric alcohols such as glycerin, erythritol, xylitol, maltitol glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerol, polyethylene glycol, 1,2-pentanediol, isoprene glycol,

NMF components, such as amino acid, sodium lactate, sodium pyrrolidone carboxylate,

Xyloglucan, Chinese quince seed, Carrageenan, Pectin, Met, Kalan, Galactan, Delmantansulfate, Glycoken, Keratansulfate, Chondroitin, Mucoitin Sulfate, Keratosulfate, Chondroitin, Mucoitin Sulfate, Kerato Water-soluble polymers such as sulfuric acid, locust bean gum, succinoglucan, calonym acid, hyaluronic acid, heparan sulfate, sodium hyaluronate, collagen, mucopolysaccharides, chondroitin sulfate,

Silicones such as dimethylpolysiloxane and methylphenylsiloxane, and

Culture supernatants, such as lactic acid bacteria and bifidus bacteria, etc. can be illustrated.

As the thickener,

Sodium alginate, chitantan gum, aluminum silicate, quince seed extract, gum arabic, hydroxyethyl guar gum, carboxymethyl guar gum, guar gum, textane, tragacanth gum, starch, chitin, chitosan, Natural polymer materials such as carboxymethyl chitin and agar,

Semisynthetic polymer materials such as cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxyoxytyl cellulose, soluble starch, cationic cellulose,

Synthetic polymer materials such as carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, vinyl alcohol and vinyl acetate copolymer, and the like.

As the antioxidant,

Dibutyl hydroxy toluene, butyl hydroxy anisole, a molasses propyl, ascorbic acid, etc. can be illustrated,

As a chelating agent,

Disodium edate, ethylenediamine tetraacetic acid, pyrrole phosphate, hexametaphosphate, quenoic acid, tartaric acid, gluconic acid, and the like can be exemplified.

As pH adjuster,

Sodium hydroxide, triethanolamine, quenoic acid, sodium quenoate, boric acid, borax, potassium hydrogen phosphate, etc. can be illustrated, respectively.

As said ultraviolet absorber and scattering agent,

Paraaminobenzoic acid ultraviolet absorber, atlanic acid ultraviolet absorber, salicylic acid ultraviolet absorber, cinnamic acid ultraviolet absorber, benzophenone ultraviolet absorber, sugar ultraviolet absorber, 3- (4-methylbenzylidene) -d-camphor, 3-benzyl Liden-d, 1-camphor, urocanic acid, urocanoic acid ethyl ester, 2-phenyl-5-methylbenbenzoxazole, 2,2-hydroxy-5-methylphenylbenzotriazole, 2- (2 -Hydroxy-5-t-octylphenyl) benzotriazole, 2- (2-hydroxy-5-methylphenyl) benzotriazole, dibenzalazine, dianisoylmethane, 4-meth Methoxy-4-t-butylbenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, 2-hydroxy-4-methoxybenzophenone, octyldimethylpara Aminobenzoate, ethylhexyl paramethoxy sinemate, titanium oxide, kaolin, talc etc. can be illustrated.

As said vitamins,

Vitamin A and its derivatives,

Vitamin Bs such as vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate and vitamin B ₆ derivatives thereof, vitamin B ₁₂ , vitamin B ₁₅ and derivatives thereof,

Ascorbic acid, ascorbic acid sulfate and salts thereof, ascorbic acid phosphate esters and salts thereof, ascorbic acid dipalmitate, ascorbic acid glucoside, acyl ascorbic acid glucoside, α-tocophenol, β-tocophenol and γ-tocophenol Vitamin E, such as vitamin E acetate,

Other examples include vitamin D, vitamin H, pantothenic acid, panthetin, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferrolic acid, γ-orizanol, α-lipoic acid, orotic acid and derivatives thereof. have.

As said amino acids,

Glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, asparagine, glutamine, taurine, tryptophan, cystine, cysteine, methionine, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine, lysine and derivatives thereof Can be illustrated.

As the antimicrobial agent,

Benzoic acid, salicylic acid, sorbic acid, laraoxy benzoic acid alkyl ester, hexacrofen, etc. can be illustrated.

As the seaweed extract,

Extracts from brown algae, red algae, green algae, south algae, and the like, specifically kelp, kelp, seaweed, green cabbage, wood starfish, coral horse, palmaria, seaweed, green seaweed, green onion, and ascophyllum , Extracts from Fucus, large horsetail, Okinawa large horsetail, Himanthalia and the like can be exemplified.

As said various medicines,

Nicotinic acid amide, benzyl nicotinic acid, γ-orizanol, alanthrin, glycyrrhizin acid (salt), glycyrrhetinic acid and its derivatives, hinokithiol, bisabolol, eucarpton, thymol, inositol, psychosaponin, ginseng saponin, scum saponin And saponins such as non-saturated tree saponins, pantothenyl ethyl ether, ethynyl esradiol, tranexamic acid, arbutin, separanthin, placenta extract and the like can be exemplified.

Table 1 below is a table relating to an example of preparing a nutrient cosmetics according to a conventional method by containing a nanoemulsion in the composition and content described below.

 ingredient  Example 1  Example 2  Example 3  Example 4  Example 5  Organic Groups with Amino Groups  0.1wt%  0.1wt%  0.02wt%  0.02wt%  0.5wt%  Gold acetylide compounds  0.001wt%  0.01wt%  0.0001wt%  0.001wt%  0.05wt%  ethanol  5wt%  5wt%  5wt%  5wt%  5wt%  1,3-butylene glycol  2.0wt%  2.0wt%  2.0wt%  2.0wt%  2.0wt%  Polyoxyethylene Transdermal Pajama Oil  0.05wt%  0.05wt%  0.05wt%  0.05wt%  0.05wt%  Methyl paraoxybenzoate  0.1wt%  0.1wt%  0.1wt%  0.1wt%  0.1wt%  Hyaluronic acid  0  0.2wt%  0  0.2wt%  0.2wt%  Distilled water  Remainder  Remainder  Remainder  Remainder  Remainder

Nutritional longevity which is one of the nano-emulsion skin anti-aging cosmetic composition of the present invention prepared by the examples of Table 1,

A safe and effective amount of organic substance having excellent characteristics as a biological response modifier, having interferon organic activity, activation of microphages and NK cells, or antitumor activity, and exhibiting desirable pharmacological activity such as inhibition of enkephalinase and calcium metabolism improvement. With germanium,

Gold acetylide compound, which is an organometallic complex that does not cause abnormalities on skin with noble metal catalysts, has pharmacological activation effects such as 1,3-butylene glycol and hyaluronic acid, which act as moisturizing agents, and further move the organic compounds. By further improving / promoting, the active ingredient of the active compound is greatly improved to be delivered deep into the skin.

Therefore, applying nutrient cosmetics, one of the nano-emulsion skin anti-aging cosmetic composition of the present invention to the skin, complex pharmacological ingredients penetrate deep into the skin without side effects and prevent skin aging and wrinkles.

As described above, the nanoemulsion skin anti-aging cosmetic composition of the present invention may contain cosmetics, external medicines, quasi-drugs, etc. as containing the above-mentioned main ingredients.

For example, it may be prepared and used in the form of basic cosmetics such as lotion, milky lotion, moisturizing cream, cleansing cream, massage cream, facial cleansing cream, pack, essence.

Nutritional longevity prepared in the composition ratio as shown in Table 1 is prepared only by one embodiment of the nanoemulsion skin anti-aging cosmetic composition of the present invention, the scope of the present invention according to the gist of the present invention is limited by the one embodiment It will be apparent to those skilled in the art to which the present invention pertains.

The nanoemulsion skin anti-aging cosmetic composition of the present invention as described above, the organic germanium in which a safe and effective amount of amino acid is introduced,

As other optional ingredients, bases and / or additives which are known for external skin use as well as medically acceptable ingredients, such as cosmetic ingredients, include water, alcohols, oils, surfactants, preservatives, perfumes, pigments, etc. Moisturizers, thickeners, water-soluble polymers, antioxidants, chelating agents PH modifiers, blowing agents (pigments, UV absorbers, scattering agents, powders), vitamins, amino acids, antibacterial agents, seaweed extracts, various pharmaceuticals, additives, etc. Expression of pharmacological activity,

By the expression of the role that the gold acetylide compound, which is an organometallic complex, further improves / promotes the movement of the active compound,

Since the active ingredients of the active compounds are quickly delivered deep into the skin, they not only exhibit excellent skin aging anti-wrinkle effect and transdermal absorption effect, but also exhibit excellent effects on long-term preservation, stability on skin use, and convenience of use. do.

Therefore, when various cosmetics, external medicines, quasi-drugs, etc. manufactured with the nanoemulsion skin anti-aging cosmetic composition of the present invention are used, the skin of people is kept healthy, clean, beautiful, and appear physiologically with age. There is an effect that can delay and prevent skin aging.

Claims (17)

Organo germanium with safe and effective amounts of basic amino acids

0.01 to 2wt%, Gold acetylide compound [AuC ₆ H ₁₃ O] is an organometallic complex 0.0001 ~ 0.01wt%, Water, alcohols, oils, surfactants, preservatives, fragrances, pigments, moisturizers, thickeners, water-soluble polymers, antioxidants, chelating agents PH modifiers, foaming agents; (pigments, UV absorbers, scattering agents) , Powder), vitamins, amino acids, antimicrobial agents, seaweed extract, nanoemulsion skin anti-aging cosmetic composition characterized in that it is prepared by mixing at least one selected from drugs. The method of claim 1, The gold acetylide compound, Metal salts and salts that do not cause abnormalities in the skin and metal salts including metal acids and metal salts, 2-propyn-1-ol, 1-butyn-3-ol, 3-methyl-1-butyl-3-ol, 3-methyl-1-pentin-3-ol, 1-hexane, 3.5-dimethyl-1 Acetylene derivatives selected from -hexane-3-ol and 1-ethynyl-1-cyclo nucleic acidol, Sulfite which is a reducing agent for reducing metal atoms in metal salts, Nanoemulsion skin anti-aging cosmetic composition, characterized in that an alkali salt of acetic acid is used as a substitution accelerator which accelerates the dehydration reaction of a metal atom in a metal salt or an acetylene derivative in a reduced metal atom and binds a metal atom to this part. . The method of claim 1, The oil is, Macadamia nut oil, pajama oil, olive oil, cacao oil, camellia oil, palm oil, wax, jojoba oil, grape seed oil, avocado oil, Mink oil, yolk oil animal fats, Beeswax, mercury, lanolin, carnava wax, candelilla wax, Liquid paraffin, squalene, microcrystalline wax, selesin wax, paraffin wax, petrolatum hydrocarbons, Natural and synthetic fatty acids which are capric acid, myristic acid, palmitic acid, stearic acid, behenic acid, lanolin fatty acid, linoleic acid, linolenic acid, lauric acid, myristic acid, oleic acid, isostearic acid, Natural and synthetic higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol, capryl alcohol, myristyl alcohol, cetyl alcohol and cholesterol; Nanoemulsion skin anti-aging cosmetic composition, characterized in that at least one selected from esters such as isopropyl myristate, isopropyl palmitic acid, octylate dodecyl, octylate dodecyl oleate, cholesterol oleate. The method of claim 1, As said surfactant, Sorbitan monolaurate, sorbitan monopalmitate, sorbitan sorbate, sesuccioleate, sorbitan trioleate, polyoxyethylene sorbitan monolaurate, polyoxetylene sorbitan monostearate, polyethylene glycol monooleate, Nonionic activators which are polyethylene glycol alkylates, polyoxyethylene alkyl ethers, polyglycol diethers, lauroyl diethanolamides, fatty acids, isopropanolamides, maltitol hydroxy fatty acid ethers, alkylated polysaccharides, alkylglucosides, and sugar esters; Lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerol monostearate, polyglycerol alkylate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene Nonionic surfactant which is cetyl ether, polyoxyethylenated sterol, polyoxyethylenated lanolin, polyoxyethylenated beeswax, polyoxyethylene hardened castor oil, Sodium stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl phosphate, triethanolamine palmitate, sodium polyoxyethylene lauryl phosphate, sodium N-acyl glutamate, sodium palmitate, sodium laurate, lauryl sulfate Anionic surfactant which is potassium, alkyl sulfate triethanol amine ether, linear dodecylbenzene sulfuric acid, polyoxyethylene hardened castor oil maleic acid, acyl methyl tauric acid, A cationic surfactant which is stearyl dimethylbenzyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl tri methyl ammonium chloride, benzalkonium chloride, laurylamine oxide, A nanoemulsion skin anti-aging cosmetic composition, characterized in that at least one selected from alkylaminoethylglycine chloride and an amphoteric surfactant which is lecithin. The method of claim 1, As the preservative, Benzoate, salicylate, sorbate, dehydroacetate, paraoxybenzoate, 2,4,4-trichloro-2-hydroxydiphenylether, 3,3,4-trichlorocarbanilide, chloride Nano-emulsion skin anti-aging cosmetic composition, characterized in that at least one selected from benzalkonium, hinokithiol, resorcin, ethanol. The method of claim 1, The moisturizing agent, Polyhydric alcohols such as glycerin, erythritol, xylitol, maltitol glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerol, polyethylene glycol, 1,2-pentanediol, and isoprene glycol; NMF components such as amino acid, sodium lactate, sodium pyrrolidone carboxylic acid, xyloglucan, quince seed, carrageenan, pectin, met, cadmium, galactan, delmantan sulfate, glycoken, keratan sulfate, chondroitin, mu Cotin sulfate, keratosulfate, chondroitin, mucoitin sulfate, keratosulfate, locust bean gum, succinoglucan, calonym acid, hyaluronic acid, heparan sulfate, sodium hyaluronate, collagen, mucopolysaccharide, A water-soluble high molecular substance which is chondroitin sulfate, Silicones which are dimethylpolysiloxane and methylphenylsiloxane; A nanoemulsion skin anti-aging cosmetic composition, characterized in that at least one selected from the culture supernatants which are lactic acid bacteria and bifidus bacteria. The method of claim 1, As the thickener, Sodium alginate, chitantan gum, aluminum silicate, quince seed extract, gum arabic, hydroxyethyl guar gum, carboxymethyl guar gum, guar gum, textane, tragacanth gum, starch, chitin, chitosan, Carboxymethyl chitin, natural agar material that is agar (寒 天), Cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxy acetyl cellulose, soluble starch, semi-synthetic high molecular material which is cationic cellulose, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, A nanoemulsion skin anti-aging cosmetic composition, characterized in that at least one selected from synthetic polymers such as vinyl alcohol and vinyl acetate copolymer. The method of claim 1, The antioxidant, Nanobutylemulsion skin anti-aging cosmetic composition, characterized in that at least one selected from dibutyl hydroxy toluene, butyl hydroxy anisole, molar asset propyl, ascorbic acid. The method of claim 1, The chelating agent, A nanoemulsion anti-aging cosmetic composition, characterized in that at least one selected from disodium edate, ethylenediamine tetraacetic acid, pyrrole phosphate, hexametaphosphate, quenoic acid, tartaric acid, and gluconic acid. The method of claim 1, The pH adjuster, A nanoemulsion anti-aging cosmetic composition, characterized in that at least one selected from sodium hydroxide, triethanolamine, quenoic acid, sodium quenoate, boric acid, borax, potassium hydrogen phosphate. The method of claim 1, As said ultraviolet absorber and scattering agent, Paraaminobenzoic acid ultraviolet absorber, atlanic acid ultraviolet absorber, salicylic acid ultraviolet absorber, cinnamic acid ultraviolet absorber, benzophenone ultraviolet absorber, sugar ultraviolet absorber, 3- (4-methylbenzylidene) -d-camphor, 3-benzyl Liden-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenbenzoxazole, 2,2-hydroxy-5-methylphenylbenzotriazole, 2- (2 -Hydroxy-5-t-octylphenyl) benzotriazole, 2- (2-hydroxy-5-methylphenyl) benzotriazole, dibenzalazine, dianisoylmethane, 4-meth Methoxy-4-t-butylbenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one, 2-hydroxy-4-methoxybenzophenone, octyldimethylpara Nanoemulsion anti-aging cosmetics, characterized in that at least one selected from aminobenzoate, ethylhexyl paramethoxy sinemate, titanium oxide, kaolin, talc Dangerous. The method of claim 1, The vitamins include vitamin A and its derivatives, Vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, and vitamin B ₆ derivatives thereof, vitamin B ₁₂ , vitamin B ₁₅ and vitamin B derivatives thereof, Ascorbic acid, ascorbic acid sulfate and its salt, ascorbic acid phosphate ester and its salt, ascorbic acid dipalmitate, ascorbic acid glucoside, acyl ascorbic acid glucoside, α-tocophenol, β-tocophenol, γ-tocophenol And vitamin E which is vitamin E acetate, And at least one selected from vitamin D, vitamin H, pantothenic acid, panthetin, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferrolic acid, γ-orizanol, α-lipoic acid, orotic acid and derivatives thereof. Nanoemulsion skin anti-aging cosmetic composition. The method of claim 1, The amino acids, Glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, asparagine, glutamine, taurine, tryptophan, cystine, cysteine, methionine, hydroxyproline, aspartic acid, glutamic acid, arginine, histidine, lysine and derivatives thereof Nano emulsion skin anti-aging cosmetic composition, characterized in that at least one selected. The method of claim 1, The antimicrobial agent, Nanoemulsion skin anti-aging cosmetic composition, characterized in that at least one selected from benzoic acid, salicylic acid, sorbic acid, laraoxy benzoic acid alkyl ester, hexacrofen. The method of claim 1, The seaweed extract is, Kelp, kelp, brown seaweed, green seaweed, woodpecker, coral horse, palmaria, seaweed, blue seaweed, sea green, ascophyllum, fucus, big horse, Okinawa big horse, himanthalia Nano emulsion skin anti-aging cosmetic composition, characterized in that at least one selected from. The method of claim 1, The drug, Nicotinic acid amide, benzyl nicotinic acid, γ-orizanol, alanthrin, glycyrrhizin acid (salt), glycyrrhetinic acid and its derivatives, hinokithiol, bisabolol, eucarpton, thymol, inositol, psychosaponin, ginseng saponin, scum saponin And saponins which are unaffected tree saponins,  Nano-emulsion skin anti-aging cosmetic composition, characterized in that at least one selected from pantothenyl ether, ethynyl ethradiol, tranexamic acid, arbutin, separanthin, placenta extract. Claim 1 cosmetic composition for external cosmetic composition selected from the lotion, milky lotion, moisturizing cream, cleansing cream, massage cream, face-wash cream, pack, cosmetic liquid containing the nano-emulsion anti-aging cosmetic composition.