CN109674734A - It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect and its application - Google Patents
It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect and its application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of with moisturizing, maintenance, releives, the composition of Antiageing effect and its application, and composition is made of oligopeptides -1, trehalose, Chinese herbaceous peony root extract, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, alpha-glucans oligosaccharides, chrysanthemum potato root juice, Bacillus acidi lactici, silantriol, hyaluronic acid, palmityl tripeptides -5.The present invention by addition oligopeptides -1, trehalose, Chinese herbaceous peony root extract, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, alpha-glucans oligosaccharides, chrysanthemum potato root juice, Bacillus acidi lactici, silantriol, hyaluronic acid, palmityl tripeptides -5 at subassembly, the function of product is extended, it can moisturizing but also releive maintenance and resistance skin aging；Simultaneously because this is water solubility at subassembly, so not limited by product forms, aqua, lotion, cream, essence etc. can be made an addition to.
Description
Technical field
The present invention relates to a kind of cosmetics and drug technology, more particularly to one kind to have moisturizing, maintenance, releive, anti-ageing work
Composition and its application.
Background technique
As global environmental pollution influences, the relationship of environmental pressure and skin is worsening, and sky is dirty by smog and micronic dust
It is stained with, there are also dry wind, strong ultraviolet light etc., outermost layer protects the skin of our bodies without which day not by environment pressure
Power torments.Under such environmental pressure, the immunity degradation of skin is more drier and drier, becomes to be highly susceptible to damage, gradually
Ground aging.Skin is the natural coat of human body, and most ideal beautiful skin is that moisture content, oil content are moderate, and acid-base scale of skin is moderate, skin
Skin is smooth delicate soft, and springiness is ruddy and glossy, and pore is tiny, and lines marshalling, sulci of skin moves towards in length and breadth.Skin
Outermost cuticula completely plays critically important effect in skin barrier function.When skin damage pressure is excessive, will go out
It is now faint in color, dries, casting off a skin, sensitive, wrinkle, then the problems such as skin aging.
And most of currently used cosmetics have that effect is indefinite and certain adverse reaction occur.So people
Be highly desirable to definite effect, effect by way of multiplicity, safely, have no adverse reaction have moisturizing, maintenance, releive, anti-ageing
The product of effect.
Summary of the invention
For overcome the deficiencies in the prior art, one of the objects of the present invention is to provide one kind to have moisturizing, maintenance, relaxes
Slow, Antiageing effect composition.The present invention in moisturizing is formulated by adding oligopeptides -1, trehalose, Chinese herbaceous peony (PAEONIA
LACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM) extract, α-Portugal
Chitosan oligosaccharide, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici, silantriol, hyaluronic acid, palmityl three
Peptide -5 at subassembly, extend the function of product, can moisturizing but also releive maintenance and resist skin aging；Simultaneously because should
It is water solubility at subassembly, so not limited by product forms, aqua, lotion, cream, essence etc. can be made an addition to.
The second object of the present invention be to provide it is a kind of with moisturizing, maintenance, releive, the essence of Antiageing effect dew.
The third object of the present invention be to provide it is a kind of with moisturizing, maintenance, releive, the preparation of the essence of Antiageing effect dew
Method.
An object of the present invention adopts the following technical scheme that realization: one kind having moisturizing, maintenance, releives, Antiageing effect
Composition, by oligopeptides -1, trehalose, Chinese herbaceous peony root extract, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, α-Portugal
Chitosan oligosaccharide, chrysanthemum potato root juice, Bacillus acidi lactici, silantriol, hyaluronic acid, palmityl tripeptides -5 form.
Further, the composition is applied in moisturizing, maintenance, releives, on anti-ageing essence dew, the composition
Moisturizing, maintenance, releive, the weight percent accounting in anti-ageing essence dew it is as follows: 0.05~0.25% oligopeptides -1,0.5~
2% trehalose, 0.5~2% Chinese herbaceous peony root extract, 0.5~2% biological carbohydrate gum -1,0.5~2% Cer NP,
0.5~2% Radix Cynanchi Atrati extract, 0.07~1.4% alpha-glucans oligosaccharides, 0.019~0.38% chrysanthemum potato root juice, 0.001
~0.02% Bacillus acidi lactici, 0.1~2% silantriol and hyaluronic acid, 0.000005~0.00000025% palm
Acyl tripeptides -5.
The second object of the present invention adopts the following technical scheme that realization: one kind having moisturizing, maintenance, releives, Antiageing effect
Essence dew, be prepared by the component of following percent by weight: 1~10% dipropylene glycol, 1~10% glycerol it is poly-
Ether -26,1~5% -1 composition of oligopeptides, 1~5% Fructus Hordei Germinatus oligose glucoside, 0.5~2% trehalose, 0.5~2%
Chinese herbaceous peony root extract, 0.5~2% biological carbohydrate gum -1,0.5~2% Cer NP, 0.5~2% butanediol, 0.5
~2% Radix Cynanchi Atrati extract, 0.1~2% ECOSKIN composition, 0.1~2% EPIDERMOSIL composition, 0.1~
1% SynColl composition, 0.1~1% Sodium Hyaluronate, 0.1~1% Scleroglucan, 0.01~0.02% EDTA
Disodium, 0.01~0.15% carbomer, 0.01~0.15% tromethamine, 0.1~0.2% parahydroxyacet-ophenone, 0.1
~0.5% hexylene glycol, 0.1~0.4% skin conditioning agent, surplus are water, and the sum of said components weight percent is
100%.
Further, -1 composition of oligopeptides is grouped as by the group of following percent by weight: 85% glycerol,
10% water, 5% oligopeptides -1.
Further, the ECOSKIN composition is grouped as by the group of following percent by weight: 70% alpha-glucans
Oligosaccharides, 19% chrysanthemum potato root juice, 10% maltodextrin, 1% Bacillus acidi lactici.
Further, the EPIDERMOSIL composition is grouped as by the group of following percent by weight: 95% silicon
The hyaluronic acid of alkane three pure and mild 5%.
Further, the SynColl composition is grouped as by the group of following percent by weight: 50.99975%
Water, 49% propylene glycol, 0.00025% palmityl tripeptides -5.
Further, the skin conditioning agent is grouped as by the group of following percent by weight: 1% glycerol caprylate,
12% decoyl hydroximic acid, 87% propylene glycol.
The third object of the present invention adopts the following technical scheme that realization: one kind having moisturizing, maintenance, releives, Antiageing effect
Essence dew preparation method, include the following steps:
(1) dipropylene glycol of precise formula ratio, glycerin polyether -26, -1 composition of oligopeptides, Fructus Hordei Germinatus oligose glucoside,
Trehalose, Chinese herbaceous peony root extract, biological carbohydrate gum -1, Cer NP, butanediol, Radix Cynanchi Atrati extract, ECOSKIN composition,
EPIDERMOSIL composition, SynColl composition, Sodium Hyaluronate, Scleroglucan, EDETATE SODIUM, carbomer, tromethamine,
Parahydroxyacet-ophenone, hexylene glycol, skin conditioning agent and water are held with vessel that are clean and disinfecting；
(2) in water phase pot be added water, dipropylene glycol, glycerin polyether -26, butanediol, Sodium Hyaluronate, Scleroglucan,
EDETATE SODIUM, carbomer, parahydroxyacet-ophenone, stirring, and heating treatment, stir, and keep the temperature；
(3) then, cooling is handled, and successively plus -1 composition of oligopeptides, Fructus Hordei Germinatus oligose glucoside, trehalose, Peony Root extract
Object, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, ECOSKIN composition, EPIDERMOSIL composition, SynColl group
Object, tromethamine, hexylene glycol, skin conditioning agent are closed, is stirred；
(4) cooling is handled, and filtering, is stood discharging；
(5) after the assay was approved, filling, packaging, coding；
(6) after the assay was approved, it is put in storage.
Further, the preparation method, in step (2), the heating treatment, which refers to, is warming up to 85 DEG C~95
℃；The time of the heat preservation is 25~35 minutes；In step (3), the cooling processing, which refers to, is cooled to 35~48 DEG C；In step
Suddenly in (4), the cooling processing, which refers to, is cooled to 35~40 DEG C.
Compared with prior art, the beneficial effects of the present invention are:
The present invention is mentioned by adding oligopeptides -1, trehalose, Chinese herbaceous peony (PAEONIA LACTIFLORA) root in moisturizing is formulated
Take object, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM) extract, alpha-glucans oligosaccharides, chrysanthemum potato
(POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici, silantriol, hyaluronic acid, palmityl tripeptides -5 at subassembly,
The function of product is extended, it can moisturizing but also releive maintenance and resistance skin aging；Simultaneously because this is water-soluble at subassembly
Property, so not limited by product forms, aqua, lotion, cream, essence etc. can be made an addition to.
Specific embodiment
In the following, being described further in conjunction with specific embodiment to the present invention, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
In the present invention, if not refering in particular to, all parts, percentage are unit of weight, used equipment and raw material etc.
It is commercially available or commonly used in the art.Method in following embodiments is unless otherwise instructed the normal of this field
Rule method.
It is an object of the present invention to find it is a kind of have a variety of effects by way of, can have moisturizing, maintenance, releive,
The prescription of Antiageing effect.It is a further object to provide the plant prescription with moisturizing, maintenance, releive, anti-ageing
Application in product, plant prescription according to the present invention be not yet reported so far or for moisturizing, maintenance, releive,
Anti-ageing purposes.
It is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect, by oligopeptides -1, trehalose, Peony Root extract
Object, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, alpha-glucans oligosaccharides, chrysanthemum potato root juice, Bacillus acidi lactici, silantriol, thoroughly
Bright matter acid, palmityl tripeptides -5 form.The composition can be used for moisturizing, maintenance, releive, anti-ageing cosmetics and drug.
Further, the composition is applied in moisturizing, maintenance, releives, on anti-ageing essence dew, the composition
Moisturizing, maintenance, releive, the weight percent accounting in anti-ageing essence dew it is as follows: 0.05~0.25% oligopeptides -1,0.5~
2% trehalose, 0.5~2% Chinese herbaceous peony root extract, 0.5~2% biological carbohydrate gum -1,0.5~2% Cer NP,
0.5~2% Radix Cynanchi Atrati extract, 0.07~1.4% alpha-glucans oligosaccharides, 0.019~0.38% chrysanthemum potato root juice, 0.001
~0.02% Bacillus acidi lactici, 0.1~2% silantriol and hyaluronic acid, 0.000005~0.00000025% palm
Acyl tripeptides -5.
The present invention also provides a kind of with moisturizing, maintenance, releives, the essence of Antiageing effect dew, by following weight percent
The component of meter is prepared: 1~10% dipropylene glycol, 1~10% glycerin polyether -26,1~5% oligopeptides -1 combine
Object, 1~5% Fructus Hordei Germinatus oligose glucoside, 0.5~2% trehalose, 0.5~2% Chinese herbaceous peony root extract, 0.5~2%
Biological carbohydrate gum -1,0.5~2% Cer NP, 0.5~2% butanediol, 0.5~2% Radix Cynanchi Atrati extract, 0.1~2%
ECOSKIN composition, 0.1~2% EPIDERMOSIL composition, 0.1~1% SynColl composition, 0.1~1%
Sodium Hyaluronate, 0.1~1% Scleroglucan, 0.01~0.02% EDETATE SODIUM, 0.01~0.15% carbomer,
0.01~0.15% tromethamine, 0.1~0.2% parahydroxyacet-ophenone, 0.1~0.5% hexylene glycol, 0.1~0.4%
Skin conditioning agent, surplus be water, the sum of said components weight percent be 100%.
As further embodiment, -1 composition of oligopeptides is grouped as by the group of following percent by weight:
85% glycerol, 10% water, 5% oligopeptides -1,.
As further embodiment, the ECOSKIN composition is grouped as by the group of following percent by weight:
70% alpha-glucans oligosaccharides, 19% chrysanthemum potato root juice, 10% maltodextrin, 1% Bacillus acidi lactici.
As further embodiment, the EPIDERMOSIL composition is grouped by the group of following percent by weight
At: 95% silantriol and 5% hyaluronic acid.
As further embodiment, the SynColl composition is grouped as by the group of following percent by weight:
50.99975% water, 49% propylene glycol, 0.00025% palmityl tripeptides -5.
As further embodiment, the skin conditioning agent is grouped as by the group of following percent by weight: 1%
Glycerol caprylate, 12% decoyl hydroximic acid, 87% propylene glycol.
As shown in table 1, there is moisturizing for the present invention, maintenance, releive, the formula composition of the essence of Antiageing effect dew.
1 present invention of table has moisturizing, maintenance, releives, the formula of the essence of Antiageing effect dew
The invention has the advantages that: by moisturizing, (the inhuman widow of oligopeptides -1 for maintenance, releiving, being added in anti-ageing essence dew
Peptide -1), OLIGOPEPTIDE-1 has put on record CFDA Listed in Bureau of Drugs Supervision, meets Chinese law and regulations.Oligopeptides -1 is in nineteen sixty-eight, quilt
Pickar and Pilgeram discovery, is a kind of small-molecular peptides being made of 3 amino acid, is ECM protein, in I-type collagen
Amino acid sequence, can activate and adjust skin repair process by the albumen enzyme r e lease of wound location, these molecules of release.
Oligopeptides -1, which has, promotes promoting epidermization, and stimulation extracellular matrix (ECM), I-type collagen, III collagen type generate, and repair
Skin barrier improves red capillary, anti-ageing tender skin, the function of bright color.The oligopeptides -1 purchased to winkey company.
Trehalose is a kind of natural carbohydrate, belongs to small molecule moisturizer, has good compatibility with memebrane protein, can be used as skin
Skin bleeding agent increases absorption of the skin to nutritional ingredient.The aquation function of increasing cell, there is good moisture retention.
Chinese herbaceous peony (PAEONIA LACTIFLORA) root extract is extracted from natural plant peony, utilizes modern biological skill
Art is made, and contains Paeoniflorin, benzoic acid, Chinese herbaceous peony aglycon ketone, Paeonol, gallic acid and its derivative etc..Paeoniflorin and peace
The allergic inflammation reaction of Ig-E complex induction can be improved by ceasing fragrant acid, and can inhibit certain pathogenic bacterias and fungi.Paeonol
Have the function of analgesia, anti-inflammatory, antipyretic and inhibition allergy.To pain caused by the physical or chemical factories such as cold and hot, cosmetics
Pain trace is itched, and tool improves significantly.To by carrageenan, egg white, tartaric acid, preservative, essence and surfactant (12
Sodium alkyl sulfate) etc. caused by allergy and the inflammatory reactions such as red capillary significantly inhibit.Gallic acid, gallic acid
Methyl esters can remove DPPH free radical, and to Anti-lipid peroxidation, also can inhibit the NIH/3T3 of hydrogen peroxide-induced into fiber
The DNA damage of cell.
Biological -1 hydratability of carbohydrate gum is strong, can absorb water in low-humidity environment, there is good moisture retention and wetting
Property, it is widely used as the softening and lubricating agent and humidizer of cosmetics；Biological carbohydrate gum -1 can be used as the antibody of a variety of viruses, there is anti-inflammatory.
Cer NP can penetrate into skin quickly, help the update of skin natural containment, can promote nature aquation
Balance and cuticula in water combine, form a kind of reticular structure, lock moisture.There is good action to skin moisturizing maintenance,
It is skin-active ingredient important in cuticula, skin barrier can be enhanced, reconstituted cell forms effective barrier to prevent water loss
With the influence for reducing external environment.The especially needed more ceramides of stimulated skin, some researches show that wipe containing nerve
The product of amide component can be reduced red and swollen and percutaneous water loss, plays enhancing skin barrier and impaired skin is helped to alleviate drying
The effect of state.
Tradition application it is upper, radix cynanchi atrati can with fall fire, therefore can the typhoid fever later period or postpartum consumption energy and blood of human body and body fluid and
Internal low fever does not weaken and cures fever, cough, diuresis, useless fellow, malignant sore, pharynx due to caused by waste heat after physical fatigue symptom
Laryngitis is used on wound that snake stings.In skin care, in the research that the growth with inflammatory reaction correlation factor hinders effect,
Radix cynanchi atrati (CYNANCHUM ATRATUM) extract has apparent inhibitory effect to the growth of IL-1 (Interleukin-1), i.e.,
Radix cynanchi atrati (CYNANCHUM ATRATUM) extract has good antiphlogistic effects.
Skin probiotic: alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici pass through
The antibacterial of activation skin itself resists effect to play effect, has the microbial barrier for strengthening skin, hence it is evident that it is micro- to improve skin
The skin effect of fluctuating.ECOSKIN composition of the present invention is the ECOSKIN purchased to SOLABIA Group company.
Silantriol, hyaluronic acid, by the hyaluronic acid (150-600 thousand of three alcohol groups of methyl-monosilane and low molecular weight
It Er Dun) combines and is formed.The characteristics of by silanol, small-molecular-weight hyaluronic acid, is optimised, improves its permeability and biology benefit
With rate.Epidermis caused by aging can be prevented thinning, promote update of the hyaluronic acid to epidermis and cell, promote skin keratin thin
Born of the same parents generate more hyaluronic acids and Portugal's ammonia polyose of candy.Prevent the formation of hyaluronic acid proinflammatory segment.This product is in addition to there is moisturizing
Effect is outer, and main function is resistant to aging, promotes epidermal renewal, reaches and subtracts compact, the effect of plentiful Q bullet of wrinkling.Of the invention
EPIDERMOSIL composition is the EPIDERMOSIL purchased to Exsymol company.
Palmityl tripeptides -5 promote skin cell growth, inhibit oxygen radical and hydroxyl radical free radical, promote stromatin
The synthesis of (matrix protein) especially collagen, while being also possible to increase elastin laminin, hyaluronic acid, glycosaminoglycan
With the generation of fibronectin.Such victory peptide promotes the synthesis of collagen by increasing stroma cell activity, so that skin
Seem more aobvious elasticity and youth.Hyaluronic acid (HA) synthesis for increasing collagen and cytoplasm, loses microgroove, skin
It is solid.SynColl composition of the invention is the SynColl purchased to DSM N. V..
It has been investigated that -1 composition of oligopeptides (glycerol, water, oligopeptides -1): trehalose: Chinese herbaceous peony (PAEONIA
LACTIFLORA) root extract: biological carbohydrate gum -1: Cer NP: radix cynanchi atrati (CYNANCHUM ATRATUM) extract:
ECOSKIN composition (alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, maltodextrin, Bacillus acidi lactici):
EPIDERMOSIL composition (silantriol, hyaluronic acid): SynColl composition (water, propylene glycol, palmityl tripeptides -5) is most
Preferred consumption proportion is=5:2:2:2:2:2:2:2:1.This with moisturizing, maintenance, releive, the composition of Antiageing effect is real
The core component of existing function of the present invention, can be used alone, and can also be used as additive compound use, thoroughly compensates for commercially available production
The obvious shortcoming that product have a single function.This with moisturizing, maintenance, releive, the preparation method of the composition of Antiageing effect: 1. need
When, at normal temperature, SynColl composition, EPIDERMOSIL composition is added, stirs evenly；2. ECOSKIN group is then added
Close object, -1 composition of oligopeptides, Chinese herbaceous peony (PAEONIA LACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati
(CYNANCHUM ATRATUM) extract, stirs evenly；3. being eventually adding trehalose, stir evenly, it is spare.
This with moisturizing, maintenance, releive, the essence of Antiageing effect dew preparation method, include the following steps:
(1) dipropylene glycol of precise formula ratio, glycerin polyether -26, -1 composition of oligopeptides, Fructus Hordei Germinatus oligose glucoside,
Trehalose, Chinese herbaceous peony root extract, biological carbohydrate gum -1, Cer NP, butanediol, Radix Cynanchi Atrati extract, ECOSKIN composition,
EPIDERMOSIL composition, SynColl composition, Sodium Hyaluronate, Scleroglucan, EDETATE SODIUM, carbomer, tromethamine,
Parahydroxyacet-ophenone, hexylene glycol, skin conditioning agent and water are held with vessel that are clean and disinfecting；
(2) in water phase pot be added water, dipropylene glycol, glycerin polyether -26, butanediol, Sodium Hyaluronate, Scleroglucan,
EDETATE SODIUM, carbomer, parahydroxyacet-ophenone, stirring, and heating treatment, stir, and keep the temperature；
(3) then, cooling is handled, and successively plus -1 composition of oligopeptides, Fructus Hordei Germinatus oligose glucoside, trehalose, Peony Root extract
Object, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, ECOSKIN composition, EPIDERMOSIL composition, SynColl group
Object, tromethamine, hexylene glycol, skin conditioning agent are closed, is stirred；
(4) cooling is handled, and filtering, is stood discharging；
(5) after the assay was approved, filling, packaging, coding；
(6) after the assay was approved, it is put in storage.
As further embodiment, the preparation method, in step (2), the heating treatment refers to heating
To 85 DEG C~95 DEG C；The time of the heat preservation is 25~35 minutes；In step (3), the cooling processing, which refers to, is cooled to 35
~48 DEG C；In step (4), the cooling processing, which refers to, is cooled to 35~40 DEG C.
It is specific embodiment of the present invention below, used raw material, equipment etc. remove special limit in the following embodiments
It can be obtained by buying pattern outside fixed.
Embodiment 1-3 and comparative example 1:
There is moisturizing according to the formula preparation of the following table 2, maintenance, releive, the essence of Antiageing effect dew
The essence of 2 embodiment 1-3 of table and comparative example 1 dew formula
It is as follows that the essence of embodiment 1-3 and comparative example 1 reveals specific preparation process:
1, various raw materials in precise formula are held with vessel that are clean and disinfecting；
2, water, dipropylene glycol, glycerin polyether -26, butanediol, Sodium Hyaluronate, pyrenomycetes are added in water phase pot
(SCLEROTIUM ROLFSSII) glue, EDETATE SODIUM, carbomer, parahydroxyacet-ophenone, stirring are warming up to 85 DEG C~95 DEG C, fill
Divide and stir evenly, keeps the temperature 25~35 minutes；
3, when being cooled to 35~48 DEG C, glycerol, water, oligopeptides -1, Fructus Hordei Germinatus oligose glucoside, trehalose, Chinese herbaceous peony are sequentially added
(PAEONIALACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM) are extracted
Object, alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, maltodextrin, Bacillus acidi lactici, silantriol, thoroughly
Bright matter acid, water, propylene glycol, palmityl tripeptides -5, tromethamine, hexylene glycol, glycerol caprylate, decoyl hydroximic acid, propylene glycol, fill
Divide and stirs evenly；
4,35~40 DEG C are cooled to, filtering, is stood discharging；
5, after the assay was approved, filling, packaging, coding；
6, it after the assay was approved, is put in storage.
Effect assessment
The effect of essence dew and certain commercially available brand essence dew to embodiment 1-3, comparative example 1 detects, detection project
And result is referring to table 3-6.
1, replenishing water and preserving moisture performance test
Female volunteers of 10 ages between 18~50 are looked for, in 20 DEG C, the indoor environment of relative humidity 50%, point
Draw one 2 square centimeters of fixed area in forehead, fixed area using the above moisturizing, maintenance, releive, anti-ageing essence
After dew and commercially available common essence dew, tested with Corneometer CM285 skin moisture detector, the comprehensive humidity of skin that obtains becomes
Change data, test result is as follows table 3:
Table 3 is the replenishing water and preserving moisture effect data of each embodiment and comparative example
It can be seen that make-up water percentage of the present invention and moisturizing rate from the above experimental result, be relatively not added with oligopeptides -1, trehalose, Chinese herbaceous peony
Medicine (PAEONIA LACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM) mention
Take object, alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici, silantriol, hyaluronic acid,
The moisturizing of the reference examples of -5 composition of palmityl tripeptides and commercially available common essence dew and moistening effect are significant.
2, lactic acid shouting pain is tested
Pre-selection 25 are used as lactic acid sensitive subjects, at 20 DEG C, the interior of relative humidity 50% in tested volunteer (24 to 67 years old)
In environment, draw one 2 square centimeters of fixed area in forehead respectively, fixed area using the above moisturizing, maintenance, releive,
Anti-ageing essence dew and commercially available common essence dew, study subject uses once daily, is used continuously 7 days, does not use during test
Other any products.Fixed area using the above moisturizing, maintenance, releive, anti-ageing essence dew and commercially available common essence reveal 1h
Apply 10% lactic acid solution, its itch effect of testing and assessing after with 7 days at fixed area again.
In the case where dermatologist supervises, minute (no intensity) marks tingling sensation and continues 5 points subject from 0 to 3 per minute
Clock.If being better than 3 in the 3rd and the 5th minute mark value, then it is assumed that subject is shouting pain person.
Table 4 is the lactic acid Sting results data of each embodiment and comparative example
| Sample | Before use | After 1h | After 7 days |
| Embodiment 1 | 5.8 | 3.8 | 3.0 |
| Embodiment 2 | 5.9 | 4.0 | 3.1 |
| Embodiment 3 | 5.6 | 4.6 | 3.3 |
| Reference examples | 5.8 | 5.1 | 4.9 |
| Commercially available common essence dew | 5.9 | 5.7 | 5.6 |
Most subjects, which are felt, quickly releives effect and feeling of pain, sense of discomfort, erythema, itch intensity and scorching hot
The decrease of sense.It can be seen that the present invention effect of releiving from the above experimental result, be relatively not added with oligopeptides -1, trehalose, Chinese herbaceous peony
(PAEONIA LACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM) are extracted
Object, alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici, silantriol, hyaluronic acid, palm fibre
The significant effect of releiving of the reference examples of -5 composition of palmitic acid acyl tripeptides and commercially available common essence dew.
3, impaired skin is helped to restore test
Female volunteers of 15 ages between 18~50 are looked for, in 20 DEG C, the indoor environment of relative humidity 50%, point
The fixed area that one 2 square centimeters are drawn in forehead, in fixed area with the immersion of 5%SDS lotion 2 hours to destroy skin,
Then fixed area using the above moisturizing, maintenance, releive, anti-ageing essence dew and commercially available common essence dew twice daily, hold
Continuous fortnight, with the aquation of cutin measuring appliance measurement arm, the comprehensive skin hydration that obtains acts on delta data (aquation
Value is higher to illustrate that the skin that is destroyed must be better by maintenance), test result is as follows table:
Table 5 is the impaired skin recovery effects data of each embodiment and comparative example
It can be seen that skin repair effect of the present invention from the above experimental result, be relatively not added with oligopeptides -1, trehalose, Chinese herbaceous peony
(PAEONIA LACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM) mention
Take object, alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici, silantriol, hyaluronic acid,
The skin repair significant effect of the reference examples of -5 composition of palmityl tripeptides and commercially available common facial mask.
4, skin smoothness change rate is tested
Look for female volunteers of 10 ages between 18~50 years old, respectively face using above have moisturizing, maintenance,
It releives, the essence of anti-ageing skin dew and commercially available common essence dew, study subject are used once daily, is used continuously 30 days, test
Period does not use other any products.Under the conditions of 25 ± 1 DEG C of environment temperature, humidity 50 ± 5%, using VISIA face-image
Analyzer test, comprehensive to obtain smoothness data, data value is higher, and expression skin smoothness is poorer.Test result is as follows table:
Table 6 is the skin smoothness variation effect data of each embodiment and comparative example
| Sample | Before use | After use |
| Embodiment 1 | 2.9352 | 1.6211 |
| Embodiment 2 | 2.9153 | 1.6674 |
| Embodiment 3 | 2.8873 | 1.7208 |
| Reference examples | 2.9378 | 2.7321 |
| Commercially available common essence dew | 2.8986 | 2.8653 |
From the above experimental result can be seen that the present invention to free radical scavenging activity height, be relatively not added with oligopeptides -1, trehalose,
Chinese herbaceous peony (PAEONIA LACTIFLORA) root extract, biological carbohydrate gum -1, Cer NP, radix cynanchi atrati (CYNANCHUM ATRATUM)
Extract, alpha-glucans oligosaccharides, chrysanthemum potato (POLYMNIA SONCHIFOLIA) root juice, Bacillus acidi lactici, silantriol, hyalomitome
The skin smoothness of acid, the reference examples of -5 composition of palmityl tripeptides and commercially available common essence dew is good.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. it is a kind of with moisturizing, maintenance, releive, the composition of Antiageing effect, which is characterized in that by oligopeptides -1, trehalose, Chinese herbaceous peony
Medicine root extract, biological carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, alpha-glucans oligosaccharides, chrysanthemum potato root juice, Bacillus acidi lactici, silicon
Alkane triol, hyaluronic acid, palmityl tripeptides -5 form.
2. composition as described in claim 1, which is characterized in that apply in moisturizing, maintenance, releive, anti-ageing essence dew
On, the composition moisturizing, maintenance, releive, weight percent accounting in anti-ageing essence dew it is as follows: 0.05~0.25%
The trehalose of oligopeptides -1,0.5~2%, 0.5~2% Chinese herbaceous peony root extract, 0.5~2% biological carbohydrate gum -1,0.5~2%
Cer NP, 0.5~2% Radix Cynanchi Atrati extract, 0.07~1.4% alpha-glucans oligosaccharides, 0.019~0.38% chrysanthemum
Potato root juice, 0.001~0.02% Bacillus acidi lactici, 0.1~2% silantriol and hyaluronic acid, 0.000005~
0.00000025% palmityl tripeptides -5.
3. it is a kind of with moisturizing, maintenance, releive, the essence of Antiageing effect dew, which is characterized in that by following percent by weight
Component is prepared: 1~10% dipropylene glycol, 1~10% glycerin polyether -26,1~5% -1 composition of oligopeptides, 1~
5% Fructus Hordei Germinatus oligose glucoside, 0.5~2% trehalose, 0.5~2% Chinese herbaceous peony root extract, 0.5~2% biology sugar
The Cer NP of glue -1,0.5~2%, 0.5~2% butanediol, 0.5~2% Radix Cynanchi Atrati extract, 0.1~2%
ECOSKIN composition, 0.1~2% EPIDERMOSIL composition, 0.1~1% SynColl composition, 0.1~1%
Sodium Hyaluronate, 0.1~1% Scleroglucan, 0.01~0.02% EDETATE SODIUM, 0.01~0.15% carbomer,
0.01~0.15% tromethamine, 0.1~0.2% parahydroxyacet-ophenone, 0.1~0.5% hexylene glycol, 0.1~0.4%
Skin conditioning agent, surplus be water, the sum of said components weight percent be 100%.
4. essence dew as claimed in claim 3, which is characterized in that -1 composition of oligopeptides is by following percent by weight
Group is grouped as: 85% glycerol, 10% water, 5% oligopeptides -1.
5. essence dew as claimed in claim 3, which is characterized in that the ECOSKIN composition is by following percent by weight
Group be grouped as: 70% alpha-glucans oligosaccharides, 19% chrysanthemum potato root juice, 10% maltodextrin, 1% Bacillus acidi lactici.
6. essence dew as claimed in claim 3, which is characterized in that the EPIDERMOSIL composition is by following weight percent
Number meter groups be grouped as: 95% silantriol and 5% hyaluronic acid.
7. essence dew as claimed in claim 3, which is characterized in that the SynColl composition is by following percent by weight
Group be grouped as: 50.99975% water, 49% propylene glycol, 0.00025% palmityl tripeptides -5.
8. essence as claimed in claim 3 dew, which is characterized in that the skin conditioning agent by following percent by weight group
It is grouped as: 1% glycerol caprylate, 12% decoyl hydroximic acid, 87% propylene glycol.
9. it is a kind of with moisturizing, maintenance, releive, the essence of Antiageing effect dew preparation method, which is characterized in that including walking as follows
It is rapid:
(1) dipropylene glycol of precise formula ratio, glycerin polyether -26, -1 composition of oligopeptides, Fructus Hordei Germinatus oligose glucoside, seaweed
Sugar, Chinese herbaceous peony root extract, biological carbohydrate gum -1, Cer NP, butanediol, Radix Cynanchi Atrati extract, ECOSKIN composition,
EPIDERMOSIL composition, SynColl composition, Sodium Hyaluronate, Scleroglucan, EDETATE SODIUM, carbomer, tromethamine,
Parahydroxyacet-ophenone, hexylene glycol, skin conditioning agent and water are held with vessel that are clean and disinfecting；
(2) water, dipropylene glycol, glycerin polyether -26, butanediol, Sodium Hyaluronate, Scleroglucan, EDTA are added in water phase pot
Disodium, carbomer, parahydroxyacet-ophenone, stirring, and heating treatment, stir, and keep the temperature；
(3) then, cooling is handled, successively plus -1 composition of oligopeptides, Fructus Hordei Germinatus oligose glucoside, trehalose, Chinese herbaceous peony root extract, life
Object carbohydrate gum -1, Cer NP, Radix Cynanchi Atrati extract, ECOSKIN composition, EPIDERMOSIL composition, SynColl composition,
Tromethamine, hexylene glycol, skin conditioning agent, stir；
(4) cooling is handled, and filtering, is stood discharging；
(5) after the assay was approved, filling, packaging, coding；
(6) after the assay was approved, it is put in storage.
10. preparation method as claimed in claim 9, which is characterized in that in step (2), the heating treatment refers to heating
To 85 DEG C~95 DEG C；The time of the heat preservation is 25~35 minutes；In step (3), the cooling processing, which refers to, is cooled to 35
~48 DEG C；In step (4), the cooling processing, which refers to, is cooled to 35~40 DEG C.
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