CN111544370A - Composition capable of regulating and maintaining skin microecological balance - Google Patents
Composition capable of regulating and maintaining skin microecological balance Download PDFInfo
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- CN111544370A CN111544370A CN202010459257.9A CN202010459257A CN111544370A CN 111544370 A CN111544370 A CN 111544370A CN 202010459257 A CN202010459257 A CN 202010459257A CN 111544370 A CN111544370 A CN 111544370A
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- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 230000001105 regulatory effect Effects 0.000 title claims abstract description 17
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000006041 probiotic Substances 0.000 claims abstract description 28
- 235000018291 probiotics Nutrition 0.000 claims abstract description 28
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 24
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 15
- 241000186660 Lactobacillus Species 0.000 claims abstract description 15
- 238000000855 fermentation Methods 0.000 claims abstract description 15
- 230000004151 fermentation Effects 0.000 claims abstract description 15
- 229940039696 lactobacillus Drugs 0.000 claims abstract description 15
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 14
- 239000006166 lysate Substances 0.000 claims abstract description 14
- 239000000706 filtrate Substances 0.000 claims abstract description 13
- 241001530056 Athelia rolfsii Species 0.000 claims abstract description 12
- 229940064062 alpha-glucan oligosaccharide Drugs 0.000 claims abstract description 12
- 235000016709 nutrition Nutrition 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 230000000529 probiotic effect Effects 0.000 claims abstract description 8
- 239000000022 bacteriostatic agent Substances 0.000 claims abstract description 7
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 9
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- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 9
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 claims description 4
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- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 3
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- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 7
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- -1 dextran oligosaccharide Chemical class 0.000 description 4
- 229920001542 oligosaccharide Polymers 0.000 description 4
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- 238000001914 filtration Methods 0.000 description 2
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- 238000005070 sampling Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
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- 208000002874 Acne Vulgaris Diseases 0.000 description 1
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- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
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- 239000003906 humectant Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition capable of adjusting and maintaining skin microecological balance, which comprises the following components in percentage by mass: bacteriostatic agent: 38% -53.45%; skin probiotic nutritional agents: 3.96-6.0%; and (3) lactobacillus: 0.02-0.05%; yeast fermentation lysate filtrate: 40.5 to 58.02 percent. According to the composition capable of adjusting and maintaining the skin microecological balance, a good growth and propagation environment is provided for skin probiotics through lactobacillus and yeast fermentation lysate filtrate, and sclerotium rolfsii and alpha-glucan oligosaccharide provide nutrition for the skin probiotics; 1, 3-propylene glycol, 1, 2-hexanediol and p-anisic acid replace preservatives in the formula, have the functions of preservation and freshness preservation when not used, and after the preservative is applied to the skin when used, the bacteriostatic ability of the preservative is reduced to disappear under the dilution of skin moisture, so that the reproduction of probiotics is not inhibited, and the effects of regulating and keeping the skin microecological balance are achieved.
Description
Technical Field
The invention relates to the technical field of daily cosmetics, in particular to a composition capable of adjusting and maintaining the microecological balance of skin.
Background
The development of modern industry, the acceleration of urbanization process, the reduction of air quality, the acceleration of life rhythm of people, poor living habits and unreasonable skin care lead to the serious damage of microecological balance on the skin surface; so that a series of skin problems of allergy, inflammation, acne growth, premature senility and the like appear on the skin.
With the development of science, people begin to recognize the importance of skin micro-ecology, and various products for helping the skin to recover or maintain the micro-ecological balance efficacy are produced; in the current products, although ingredients can help to restore or maintain the skin micro-ecological balance, the problem of how to prevent the growth of probiotics on the skin by using fresh-keeping (preservative effect) ingredients in the formula is not solved. As is known, cosmetics are commodities requiring a certain shelf life, so that fresh-keeping (preservative) components must be added to inhibit microbial reproduction, and after the cosmetics act on skin, the fresh-keeping (preservative) components are disabled, so that a technology of not inhibiting the reproduction of probiotics is realized, and the technology is a key technology for really helping the skin to recover or keep the microecological balance.
Disclosure of Invention
In order to solve the above problems, the present invention provides a composition for regulating and maintaining the skin micro-ecological balance, which can regulate and maintain the skin micro-ecological balance and has antiseptic and fresh-keeping effects.
The purpose of the invention is realized by the following technical scheme: comprises the following components in percentage by mass:
bacteriostatic agent: 38% -53.45%;
skin probiotic nutritional agents: 3.96-6.0%;
and (3) lactobacillus: 0.02-0.05%;
yeast fermentation lysate filtrate: 40.5 to 58.02 percent.
Preferably, the bacteriostatic agent is at least one of 1, 3-propylene glycol, 1, 2-hexanediol and p-anisic acid.
Preferably, the bacteriostatic agent comprises 1, 3-propylene glycol, 1, 2-hexanediol and p-anisic acid; wherein the 1, 3-propylene glycol comprises the following components in percentage by mass: 35.5 to 46.5 percent; the mass percent of the 1, 2-hexanediol is 2.0-5.6%; the p-anisic acid comprises the following components in percentage by mass: 0.5 to 1.35 percent.
Preferably, the skin probiotic nutritional agent is at least one of scleroglucan and alpha-glucan oligosaccharide.
Preferably, the skin probiotic nutritional agent comprises scleroglucan and alpha-glucan oligosaccharide; wherein the sclerotium rolfsii gum comprises the following components in percentage by mass: 0.36-0.70%; the alpha-glucan oligosaccharide comprises the following components in percentage by mass: 3.6 to 5.3 percent.
Preferably, the lactobacillus is at least one of lactobacillus casei and lactobacillus acidophilus.
The main components of the invention are introduced:
1, 3-propanediol from corn fermentation with INCI name: 1, 3-propanediol (CAS: 504-63-2); 1, 3-propanediol is commonly used as a humectant and solvent in cosmetics; in the invention, the preservative effect is realized when the product is not used, so that the shelf life of the product is prolonged; after the skin-care product is applied on the skin, the antiseptic capability is lost, and the reproduction of probiotics can not be inhibited.
1, 2-hexanediol: INCI name: 1, 2-hexanediol (CAS: 6920-22-5); when the product is not used, the product plays a role in synergism and antisepsis, and when the product is used on skin, the product loses antiseptic and bacteriostatic ability after being diluted by skin moisture, so that the propagation of probiotics is not influenced.
p-anisic acid: INCI names are respectively: p-anisic acid (CAS:100-09-4) is an antioxidant in cosmetics in the conventional use, and in the invention, the p-anisic acid plays a role in synergism and preservation when the product is not used, and is crystallized and separated out due to the change of a dissolving environment when the product acts on skin, so that the preservation effect is lost, thereby ensuring that the propagation of probiotics is not influenced.
Sclerotium rolfsii gum: INCI name: SCLEROTIUM rolfsii (SCLEOTIUM ROLFSSII) gum (CAS: 39464-87-4); is a natural capsule-shaped glucan component, and plays roles of moisturizing, repairing, thickening and the like in skin care products; the skin probiotic preparation is mainly a component for providing nutrition for skin probiotics and promoting the propagation of the skin probiotics.
α -glucan oligosaccharide: INCI name: the alpha-glucan oligosaccharide is prepared by fermenting sucrose, is a natural oligopeptide component, plays roles of removing wrinkles, whitening, moisturizing, repairing, resisting allergy and the like in skin care products, mainly provides a nutritional component for skin probiotics and promotes the propagation of the skin probiotics; meanwhile, the skin barrier function can be repaired, and the problem of microecological imbalance caused by excessive propagation of harmful bacteria due to skin inflammation is prevented.
And (3) lactobacillus: INCI name: the lactobacillus is prepared by freeze drying and inactivation of two strains of lactobacillus casei and lactobacillus acidophilus, and plays a role in providing an environment for skin probiotics to be easy to reproduce.
Yeast fermentation lysate filtrate: INCI name: the yeast fermentation lysate filtrate is obtained by filtering the yeast fermentation lysate, and the main skin-forming probiotics provide an environment easy to reproduce, and have multiple skin-care effects of repairing, resisting aging, whitening, removing wrinkles, moisturizing and the like.
The invention has the beneficial effects that:
1. the invention utilizes the characteristics that 1, 3-propylene glycol, 1, 2-hexanediol and p-anisic acid have the antibacterial and antiseptic effects only when being completely dissolved and reaching a certain concentration and lose the antibacterial and antiseptic effects when the concentration is reduced or separated out, thereby realizing that the composition can be applied to products, can replace preservatives when the products are not opened for use, and can prolong the quality guarantee period of the products; the antiseptic effect is lost when the skin care product is used by consumers, so that the propagation of skin probiotics on the skin surface is not influenced; solves the problem that the current product must be added with preservative to destroy the microecological balance of the skin.
2. According to the invention, lactobacillus and yeast fermentation lysate filtrate acts on skin to change the ecological environment of epidermal microorganisms and improve the reproductive capacity of epidermal probiotics; the invention has obvious functions of repairing cuticle, strengthening skin barrier function and avoiding the problem of microecological imbalance caused by excessive propagation of harmful bacteria due to skin inflammation.
3. The sclerotium rolfsii gum and the alpha-glucan oligosaccharide are nutritional agents of the epidermal probiotics, are culture mediums for the propagation of the epidermal probiotics, and ensure that the epidermal probiotics can be fully propagated, so that the microecological balance of the epidermis is realized.
4. The composition capable of adjusting and maintaining the skin microecological balance can further prolong the shelf life of the product when not used through the synergistic effect of the components according to a specific ratio; when the product is used, a plurality of preservatives can lose the preservative effect, so that the sclerotium rolfsii and the alpha-glucan oligosaccharide can ensure that the propagation of skin probiotics on the skin surface is not influenced; and the preservative without the preservative effect can cooperate with lactobacillus and yeast fermentation lysate filtrate to act on the skin, so that the barrier function of the skin is further enhanced, the horny layer of the skin is repaired, and the moisture of the skin is kept.
Detailed Description
The invention will be further illustrated with reference to specific examples.
Example 1:
a composition for regulating and maintaining skin microecological balance has a composition shown in Table 1.
Table 1:
| components | Percent (%) |
| 1, 3-propanediol | 35.5 |
| 1, 2-hexanediol | 2.0 |
| p-anisic acid | 0.5 |
| Sclerotium rolfsii gum | 0.36 |
| Lactobacillus strain | 0.02 |
| α dextran oligosaccharide | 3.6 |
| Yeast fermentation lysate filtrate | 58.02 |
The preparation method comprises the following steps:
adding 1, 3-propylene glycol, 1, 2-hexanediol and p-anisic acid into a stainless steel stirring pot, heating to 40-45 ℃, keeping the temperature and stirring for more than 30 minutes at the rotating speed of 40-60 revolutions per minute until the components are completely dissolved and transparent, and cooling to 40-50 ℃; adding sclerotium rolfsii gum and alpha-glucan oligosaccharide according to the formula proportion, stirring at a low speed (the rotating speed is 20-30 revolutions per minute) until the mixture is completely dissolved and dispersed without agglomeration, starting homogenization, stirring at a stirring speed (the rotating speed is 40-60 revolutions per minute), slowly adding lactobacillus and yeast fermentation lysate filtrate into a pot, stopping homogenization after 3 minutes, keeping stirring for 10 minutes, filtering and discharging the mixture by using 500-mesh filter cloth, placing the mixture into a stainless steel storage tank, sampling and detecting the mixture according to standards of technical Specification for cosmetic safety (2015 edition), QB/T2660 and the like, and packaging, inspecting and warehousing after the mixture is qualified; the composition of example 1 was obtained which adjusted and maintained the skin's microecological balance.
Example 2:
the preparation method and the use method of example 1 were repeated according to the percentages of the components in table 2 below to obtain the composition of example 2 capable of regulating and maintaining the skin micro-ecological balance.
Table 2:
| components | Percent (%) |
| 1, 3-propanediol | 38 |
| 1, 2-hexanediol | 3 |
| p-anisic acid | 0.75 |
| Sclerotium rolfsii gum | 0.46 |
| Lactobacillus strain | 0.03 |
| α dextran oligosaccharide | 4 |
| Yeast fermentation lysate filtrate | 53.76 |
Example 3:
the preparation and use of example 1 were repeated with the following percentages of the components in table 3 to obtain the composition of example 3 that regulates and maintains the skin's microecological balance.
Table 3:
example 4:
the preparation and use of example 1 were repeated with the following percentages of the components in table 4 to obtain the skin micro-ecological balance regulating and maintaining composition of example 4.
Table 4:
| components | Percent (%) |
| 1, 3-propanediol | 43.5 |
| 1, 2-hexanediol | 4.6 |
| p-anisic acid | 1.15 |
| Sclerotium rolfsii gum | 0.65 |
| Lactobacillus strain | 0.05 |
| α dextran oligosaccharide | 5 |
| Yeast fermentation lysate filtrate | 45.05 |
Example 5:
the preparation method and the use method of example 1 were repeated according to the following percentages of the components in table 5 to obtain the composition of example 5 capable of regulating and maintaining the skin micro-ecological balance.
Table 5:
| components | Percent (%) |
| 1, 3-propanediol | 46.5 |
| 1, 2-hexanediol | 5.6 |
| p-anisic acid | 1.35 |
| Sclerotium rolfsii gum | 0.7 |
| Lactobacillus strain | 0.05 |
| α dextran oligosaccharide | 5.3 |
| Yeast fermentation lysate filtrate | 40.5 |
The compositions prepared in examples 1 to 5, which can adjust and maintain the skin micro-ecological balance, were added to the same essence bases in an amount of 10% by weight, respectively, to obtain the essences of examples 1 to 5.
Comparative examples 1 to 2:
comparative example 1: the essence base of the composition of the invention was not added (the remaining ingredients were exactly the same as the essences of examples 1-5);
comparative example 2: the existing essence for regulating the microecological balance of skin is on the market.
The test method comprises the following steps:
1. testing environmental conditions
And (3) trial environment: a daily life environment;
testing the environmental temperature: 20-22 ℃, humidity: 40% -60%, and real-time dynamic monitoring is carried out.
2. The number of volunteers
56 human volunteers.
3. Conditions of volunteers
The patients with the age of 18-45 years (wherein the proportion of male and female is 1:1), patients without serious systemic diseases, immunodeficiency or autoimmune diseases, patients without active allergic diseases, patients without constitutional hypersensitiveness, patients with skin treatment on the tested part, people who have not used hormone medicines and immunosuppressants in the last month and patients who have not participated in other clinical trials in the last three months.
4. Procedure for the preparation of the
(1) Checking the compliance of the volunteers, and randomly and averagely dividing the volunteers into 7 groups, wherein each group randomly receives one essence;
(2) wiping and sampling the cheek, forehead and nose bridge of each volunteer with a sterile cotton swab soaked with sterile normal saline, sending to a microorganism laboratory for inspection, and recording the content of strains such as propionibacterium acnes, staphylococcus epidermidis, ammonia oxidizing bacteria and the like before use; cleaning the facial skin with standard facial cleanser, wiping to dry, standing in a constant temperature and humidity waiting room for more than 20 minutes, sequentially collecting skin data (erythema, wrinkle, friction, water content, transdermal water loss rate, oil content, etc.) with VISA tester and CK tester, collecting data once every 30 minutes, collecting three times in total, and averaging; skin data were obtained for each volunteer prior to use.
(3) After cleaning the face in the same time period in the morning and evening every day, using the corresponding essence of each group according to the use requirement, continuously using for 8 weeks, collecting data and getting the test essence once every 4 days, wherein the method and time for collecting the data are the same as those in the step (2). Skin data were obtained for each volunteer after use.
(4) Counting the lifting proportion according to the skin data of each volunteer before and after use; the results of the experiments are shown in Table 6 below.
Table 6:
as can be seen from the test data in Table 6, after the essence containing the composition of the present invention of examples 1-5 was applied, Propionibacterium acnes, which is a harmful bacterium, was significantly reduced in the skin of volunteers, and the average variation value was reduced by 62.1%; the contents of beneficial bacteria such as staphylococcus epidermidis, ammonia oxidizing bacteria and the like are obviously increased by 32.7 percent and 31.6 percent respectively to the maximum; the composition of the invention has the function of remarkably regulating the microecological balance of the skin; compared with the essence of comparative example 2, the skin microorganism regulating capacity of the essence of examples 1 to 5 is not obvious, the reduction value of harmful bacteria Propionibacterium acnes in the skin is only 3.29 percent, and the change values of staphylococcus epidermidis and ammonia oxidizing bacteria are only 8.3 percent and 3.4 percent; compared with the existing products, the product has the obvious function of regulating the microecological balance of the skin.
As can be seen from table 6, the essences of examples 1 to 5 containing the composition of the present invention were compared with the essence of comparative example 1; the erythema index of the volunteer skin was greatly reduced, indicating a significant reduction in inflammation; reduction of wrinkles indicates significant wrinkle reduction efficacy; the oil content is reduced, the water content is increased, and the oil-water balance is adjusted; the percutaneous water loss rate and the friction are reduced, which indicates that the skin barrier function is repaired; the composition of the invention is added into cosmetics to act on the skin, and can remarkably regulate the micro-ecological balance of the skin.
In conclusion, the composition capable of adjusting and maintaining the skin microecological balance has the effects of better repairing, diminishing inflammation, resisting allergy, removing wrinkles, replenishing water, preserving moisture, adjusting oil and water balance and the like, and has obvious lead compared with the prior art.
The above-mentioned embodiments are merely preferred embodiments of the present invention, and the scope of the present invention should not be limited thereby, and those skilled in the art should not make any insubstantial changes and substitutions based on the scope of the present invention.
Claims (6)
1. A composition capable of adjusting and maintaining the skin microecological balance is characterized by comprising the following components in percentage by mass:
bacteriostatic agent: 38% -53.45%;
skin probiotic nutritional agents: 3.96-6.0%;
and (3) lactobacillus: 0.02-0.05%;
yeast fermentation lysate filtrate: 40.5 to 58.02 percent.
2. The composition for regulating and maintaining the skin microecological balance according to claim 1, wherein the bacteriostatic agent is at least one of 1, 3-propanediol, 1, 2-hexanediol, and p-anisic acid.
3. The composition for regulating and maintaining the skin microecological balance according to claim 2, wherein the bacteriostatic agent comprises 1, 3-propanediol, 1, 2-hexanediol, and p-anisic acid; wherein the 1, 3-propylene glycol comprises the following components in percentage by mass: 35.5 to 46.5 percent; the mass percent of the 1, 2-hexanediol is 2.0-5.6%; the p-anisic acid comprises the following components in percentage by mass: 0.5 to 1.35 percent.
4. The composition for regulating and maintaining the microecological balance of skin according to claim 1, wherein the skin probiotic nutritional agent is at least one of scleroglucan, an alpha-glucan oligosaccharide.
5. The composition for regulating and maintaining the microecological balance of skin according to claim 4, wherein the skin probiotic nutritional agent comprises scleroglucan and alpha-glucan oligosaccharide; wherein the sclerotium rolfsii gum comprises the following components in percentage by mass: 0.36-0.70%; the alpha-glucan oligosaccharide comprises the following components in percentage by mass: 3.6 to 5.3 percent.
6. The composition for regulating and maintaining the skin microecological balance according to claim 1, wherein the lactobacillus is at least one of lactobacillus casei and lactobacillus acidophilus.
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