CN103462881A - Composite capable of promoting skin micro-ecological balance and preparation method thereof - Google Patents
Composite capable of promoting skin micro-ecological balance and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composite capable of promoting skin micro-ecological balance and a preparation method of the composite. The composite comprises the following main ingredients of skin prebiotics alpha-glucan oligosaccharide, fructooligosaccharide, beta-glucan, plant extract, yeast extract and natural antibacterial agent leuconostoc/ radish root fermentation product filter liquor. According to the composite, micro-ecological balance of the skin can be fundamentally adjusted, skin health is kept, the defects that traditional cosmetics or skin care products cure symptoms, not diseases and are prone to generating side effects are overcome, and the composite has the moisture preservation, softening and tightening multi repair effects, and provides a new thought for solving the skin problems. The preparation method of the composite is simple and practicable, and active ingredients of the functional components are kept to the maximum degree by reasonably controlling reaction steps and mixing temperature.
Description
Technical field
The invention belongs to daily use chemicals and biological technical field, particularly a kind of composition and method of making the same that promotes the skin microecological balance.
Background technology
Horny layer is the physical protection barrier of skin, and the multiple-microorganism of surviving on the horny layer of every one-inch skin probably can be divided into probiotic bacteria (saprophytic bacteria) and the large class of harmful bacteria (pathogen) two.Probiotic bacteria: head staphylococcus, Ke Shi Kocuria kristinae ad, lactobacillus acidophilus, Lactobacillus pentosus ... the friend and mentor of skin, ecological flora namely; Harmful bacteria: staphylococcus aureus, propionibacterium acnes (causing acne), candida albicans (causing aging), malassezia furfur (causing dandruff), Corynebacterium xerose (oxter abnormal flavour) ... the flora harmful to skin.Various microorganisms, by competition take food perspiration, sebum and the dead bark breeding of human body, form the microbial protection barrier, prevent that the excessive breeding of harmful bacteria from even capturing, and are safeguarding skin microecosystem balance.
Skin microecosystem balance is keeping the stable of skin environment, good ambient condition can be conducive to the growth of probiotic bacteria, and probiotic bacteria quantity is more than harmful bacteria, thereby skin food (perspiration, sebum and dead bark) is sucked by probiotic bacteria, further promote the probiotic bacteria breeding, reach optimum circulation.Yet excessive clean, chemical substance, aging, lack nutrition, cold, Exposure to Sunlight, stress, medicine (particularly antibiotic) all can destroy probiotic bacteria and harmful bacteria, invade the balance between flora.When probiotic bacteria quantity reduces, they will be replaced by harmful bacteria gradually, and skin food is sucked by harmful bacteria, promote harmful bacteria further to breed, cause skin environment to change (pH increase etc.), thereby changed the environment that is conducive to the probiotic bacteria growth, reach pernicious circulation.Skin is occupied by pathogen stress such as can causing infection and inflammation, redness, pruritus, cicatrix, erythema, thereby loses the original brilliance of skin, simultaneously, causes more skin problem, skin aging even occurs.
Making up, is in conjunction with the in addition beautiful creation of own characteristic, strengthens the facial youth to feel.Many people know and want the careful cosmetics that select, because it directly and the people of skin contact, especially skin sensitivity, uses inappropriate cosmetics, often can cause skin variety of issue to occur.Developing history from cosmetics/skin care item, so far experienced following several stages: one, the chemistry epoch: process with the chemical raw material product exactly, directly be applied on skin to reach the skin Caring skin effect, the problem of its maximum is, injured skin, produces anaphylaxis etc.Two, zoic age: primary raw material is vegeto-animal fat, nutrient substance etc., and problem is to be difficult for absorbing, stopping up pore etc.Three, the plant epoch: primary raw material is plant essence etc., and shortcoming is that nutritional labeling can only arrive keratodermatitis, can't go deep into inner defect biology of correcting skin of skin.Four, move towards the microbial ecological agent skin-care ecological epoch, that is, by the microecologic regulator microecological balance of regulation of skin fundamentally, after using, skin not only can be not coarse, and can make skin obviously smooth, delicate, glossy, flexible.
Rise along with the skin microecology, utilize modern biotechnology to develop the green ecological preparation to substitute the medicines such as traditional antibiotic, hormone, fundamentally adjust and safeguard that thereby the microecological balance of skin solves skin problem, becomes the developing direction that skin care item/cosmetic field is new.
Summary of the invention
The object of the present invention is to provide a kind of composition and method of making the same that promotes the skin microecological balance.
The technical solution used in the present invention is:
A kind of compositions that promotes the skin microecological balance, it comprises following component: the beta glucan that glycerol, butanediol, Radix Hamamelidis Mollis extract, allantoin, EDTA trisodium, glycine, Herba portulacae extract, alpha-glucans oligosaccharide, xylitol, vine extract, fruit oligose, vitamin B5, Herba Centellae extract, rice chaff extract, yeast extract, betanin, polyglutamic acid, hyaluronate sodium, the degree of polymerization are 3～5, trehalose, glycyrrhizic acid dipotassium, carbamide, sodium taurocholate, bright string coccus/Radix Raphani root tunning filtrate.
Preferably, the degree of polymerization of alpha-glucans oligosaccharide is 2～5, and the degree of polymerization of fruit oligose is 2～4.
Preferably, yeast extract derives from saccharomyces cerevisiae.
A kind of compositions that promotes the skin microecological balance, count by weight, and said composition comprises following component:
The A phase materials:
26.0～71.0 parts of deionized waters,
6.0～12.0 parts of glycerol,
5.0～11.0 parts of butanediols,
2.0～5.0 parts of Radix Hamamelidis Mollis extracts,
0.05～0.15 part of allantoin,
0.03～0.05 part of EDTA trisodium;
The B phase materials:
1.0～4.0 parts of glycine,
2.0～5.0 parts of Herba portulacae extracts,
0.5～4.5 part of alpha-glucans oligosaccharide,
1.0～2.0 parts of xylitol,
2.0～5.0 parts of vine extracts,
1.0～4.0 parts of fruit oligoses,
0.5～1.0 part of vitamin B5,
0.2～0.9 part of Herba Centellae extract,
0.2～1.3 part of rice chaff extract,
0.5～0.8 part of yeast extract,
1.0～2.0 parts of betanins,
0.01～0.25 part of polyglutamic acid,
0.05～0.10 part of hyaluronate sodium,
0.1～0.6 part of beta glucan,
1.0～1.5 parts of trehaloses;
The C phase materials:
0.5～1.0 part of glycyrrhizic acid dipotassium,
2.0～6.0 parts, carbamide;
The D phase materials:
1.0～3.0 parts of sodium taurocholates,
Bright string coccus/2.0～2.5 parts of Radix Raphani root tunning filtrates.
Preferably, said composition is counted by weight, comprises following component:
The A phase materials:
36.0～61.0 parts of deionized waters,
6.0～10.0 parts of glycerol,
7.0～10.0 parts of butanediols,
2.0～5.0 parts of Radix Hamamelidis Mollis extracts,
0.08～0.12 part of allantoin,
0.03～0.05 part of EDTA trisodium;
The B phase materials:
1.0～4.0 parts of glycine,
2.0～5.0 parts of Herba portulacae extracts,
2.0～4.5 parts of alpha-glucans oligosaccharide,
1.0～2.0 parts of xylitol,
3.0～5.0 parts of vine extracts,
1.5～4.0 parts of fruit oligoses,
0.7～1.0 part of vitamin B5,
0.2～0.9 part of Herba Centellae extract,
0.5～1.3 part of rice chaff extract,
0.5～0.8 part of yeast extract,
1.0～1.5 parts of betanins,
0.10～0.25 part of polyglutamic acid,
0.05～0.08 part of hyaluronate sodium,
0.3～0.6 part of beta glucan,
1.0～1.3 parts of trehaloses;
The C phase materials:
0.6～0.9 part of glycyrrhizic acid dipotassium,
2.5～4.5 parts, carbamide,
The D phase materials:
1.4～2.6 parts of sodium taurocholates,
Bright string coccus/2.0～2.5 parts of Radix Raphani root tunning filtrates.
Preferred, said composition is counted by weight, comprises following component:
The A phase materials:
43.03 parts of deionized waters,
8.5 parts of glycerol,
9.0 parts of butanediols,
4.5 parts of Radix Hamamelidis Mollis extracts,
0.08 part of allantoin,
0.03 part of EDTA trisodium;
The B phase materials:
3.0 parts of glycine,
4.0 parts of Herba portulacae extracts,
4.0 parts of alpha-glucans oligosaccharide,
1.5 parts of xylitol,
3.0 parts of vine extracts,
3.0 parts of fruit oligoses,
0.9 part of vitamin B5,
0.8 part of Herba Centellae extract,
1.0 parts of rice chaff extracts,
0.6 part of yeast extract,
1.5 parts of betanins,
0.20 part of polyglutamic acid,
0.06 part of hyaluronate sodium,
0.5 part of beta glucan,
1.1 parts of trehaloses;
The C phase materials:
0.8 part of glycyrrhizic acid dipotassium,
4.0 parts, carbamide,
The D phase materials:
2.5 parts of sodium taurocholates,
Bright string coccus/2.4 parts of Radix Raphani root tunning filtrates.
A kind of preparation method that promotes the compositions of skin microecological balance comprises the following steps:
1) the A phase materials is added in the water pot, be heated to 81 ℃～84 ℃, insulated sterilizing;
2) treat that the A phase materials is cooled to 36 ℃～40 ℃, mix with the B phase materials, join in the emulsifying pot, stir;
3) treat that in the emulsifying pot, temperature of charge is down to 35 ℃～38 ℃, add the C phase materials, stir;
4) treat that in the emulsifying pot, temperature of charge is down to 28 ℃～32 ℃, add the D phase materials, rear discharging stirs.
Preferably, step 1) insulation sterilizing in 25～35 minutes.
The invention has the beneficial effects as follows:
The present composition can promote the propagation of body surface probiotic bacteria, does not stimulate the harmful bacteria growth simultaneously, has relatively suppressed the propagation of harmful bacteria, plays the effect that promotes skin microecological balance, the Maintenance Of Skin Health.
The present invention is by skin prebiotics, plant, yeast extract and functional additive compatibility, can jointly help skin opposing environmental stimuli, and contribute to the effective absorption of skin to active skin protection composition, further nourishes rough skin, keep skin moistening, soft, compact, there is multiple repairing effect.
The present composition is the microecological balance of regulation of skin fundamentally, has overcome the defect that traditional cosmetics/skin care item are cured the symptoms, not the disease and easily had side effects, and for solving skin problem, provides new thinking.
The preparation method of the present composition is simple, by reasonable control reactions steps and mixing temperature, has farthest kept the active ingredient of each function component.
The specific embodiment
The invention provides a kind of compositions that promotes the skin microecological balance, said composition comprises prebiotics, and prebiotics is the best natural medium of various probiotic bacterias, optionally stimulates the amount reproduction of probiotic bacteria.Prebiotics is various in style, also difference to some extent of physical and chemical performance, physiological property between different cultivars, so application also is not quite similar.Due to differing greatly of environment for use, the prebiotics that is applicable to skin is different from conventional intestinal prebiotics.The inventor studies and finds alpha-glucans oligosaccharide (α-Glucooligosaccharides) with fruit oligose (Fructooligosaccharide) but the propagation of the resident bacterium of composite effective stimulus non-pathogenic skin, does not stimulate the pathogen growth simultaneously.The degree of polymerization of alpha-glucans oligosaccharide is preferably 2～5, most preferably is 3, and the degree of polymerization of fruit oligose is preferably 2～4, most preferably is 2.Alpha-glucans oligosaccharide, fruit oligose prebiotics are for the most common and realized the oligosaccharide that industrial scale is produced in the market, and price is relatively low.In addition, the inventor also finds that the beta glucan that the degree of polymerization is 3～5 also can be used as good skin prebiotics, and most preferably the degree of polymerization is 3, and by itself and alpha-glucans oligosaccharide, the composite use of fruit oligose, skin effect is better.
The present composition also comprises the bright string coccus of Radix Hamamelidis Mollis extract, Herba portulacae extract, vine extract, Herba Centellae extract, rice chaff extract, yeast extract and natural antibacterial agent/Radix Raphani root tunning filtrate, these natural extracts carry out compatibility can produce collaborative and complementary effect, when promoting the growth of skin probiotic bacteria, also can jointly bring into play the multi-efficiency of convergence, nourishing, whitening, delay skin aging.The said extracted thing can be bought from suppliers, also can be prepared by extracting method well known to those skilled in the art.
Further; the invention provides preferred other functional additives and carrier with prebiotics, plant extract, yeast extract compatibility, comprising: wetting agent (glycerol, butanediol, hyaluronate sodium, polyglutamic acid), skin conditioning agent (allantoin, trehalose glycyrrhizic acid dipotassium, carbamide, glycine), vitamin B5, chelating agen EDTA trisodium, surfactant (betanin), sodium taurocholate.By above component compatibility, contribute to the effective absorption of skin to plant extract, yeast extract active ingredient, further nourishes rough skin, bring into play the effect of multiple reparation.
The present composition is specially adapted to operational maintenance and the unbalance treatment of flora of skin of face.Certainly, also can be used for other positions such as neck, trunk, hands, arm, lower limb with the regulation of skin situation.
Below in conjunction with embodiment, further set forth content of the present invention.
Raw materials used as shown in table 1 in embodiment.Following embodiment is only the preferred case study on implementation of the present invention, can not limit the present invention's scope required for protection with this.
The raw materials used source of table 1
| Glycerol | Section's Ninghua work (China) company limited |
| Butanediol | OXEA |
| The Radix Hamamelidis Mollis extract | Jiujiang Hua Han bio tech ltd |
| Allantoin | Shandong markon's good fortune pharmaceutical Co. Ltd |
| The EDTA trisodium | BASF |
| Glycine | The handsome prosperous bio tech ltd in Xi'an |
| Herba portulacae extract | The auspicious enlightening bio tech ltd in Xi'an |
| The alpha-glucans oligosaccharide | The magnificent mutually beneficial biochemical industry in Beijing |
| Xylitol | Feitian, Shandong science and technology group |
| The vine extract | Changsha Hua Kang biotechnology development corporation, Ltd. |
| Fruit oligose | The auspicious biotechnology of Hunan sunrise Co., Ltd |
| Vitamin B5 | Great Hua Guanji, Jinan bio tech ltd |
| Herba Centellae extract | Jiujiang Hua Han bio tech ltd |
| The rice chaff extract | Jiangsu Jian Jia pharmaceutcal corporation, Ltd |
| Yeast extract | Zhejiang Shen You Bioisystech Co., Ltd |
| Betanin | Shandong markon's good fortune pharmaceutical Co. Ltd |
| Polyglutamic acid | Nanjing Sai Taisi bio tech ltd |
| Hyaluronate sodium | The green biotechnology company limited of Xi'an gold |
| Beta glucan | Zhejiang Shen You Bioisystech Co., Ltd |
| Trehalose | The Jiangmen city peaking work raw material company limited that overflows |
| Glycyrrhizic acid dipotassium | Wuhan City's inscription industry development in science and technology company limited |
| Carbamide | Shandong markon's good fortune pharmaceutical Co. Ltd |
| Sodium taurocholate | Jing Sha Bandung pharmaceutical Co. Ltd |
| Bright string coccus/Radix Raphani root tunning filtrate | The Active Concepts(U.S.) |
Embodiment
Table 2 composite formula (weight portion)
| ? | Compositions 1 | Compositions 2 | Compositions 3 | Compositions 4 | Compositions 5 | Compositions 6 | Compositions 7 | Compositions 8 |
| The A phase materials: | ? | ? | ? | ? | ? | ? | ? | ? |
| Deionized water | 55.64 | 43.03 | 35.41 | 55.55 | 61.23 | 36.94 | 26.35 | 70.37 |
| Glycerol | 7.0 | 8.5 | 10 | 8.0 | 6.0 | 10 | 12 | 6.0 |
| Butanediol | 7.0 | 9.0 | 10 | 8.0 | 7.0 | 10.0 | 11 | 5.0 |
| The Radix Hamamelidis Mollis extract | 4.0 | 4.5 | 5.0 | 3.5 | 3.0 | 5.0 | 5.0 | 2.0 |
| Allantoin | 0.10 | 0.08 | 0.12 | 0.10 | 0.08 | 0.12 | 0.15 | 0.05 |
| The EDTA trisodium | 0.03 | 0.03 | 0.04 | 0.05 | 0.04 | 0.04 | 0.05 | 0.03 |
| The B phase materials: | ? | ? | ? | ? | ? | ? | ? | ? |
| Glycine | 2.0 | 3.0 | 3.5 | 1.0 | 2.0 | 3.0 | 4.0 | 1.0 |
| Herba portulacae extract | 2.0 | 4.0 | 4.5 | 3.5 | 2.0 | 4.0 | 5.0 | 2.0 |
| The alpha-glucans oligosaccharide | 3.0 | 4.0 | 4.5 | 2.5 | 2.0 | 4.0 | 4.5 | 0.5 |
| Xylitol | 1.0 | 1.5 | 1.8 | 1.0 | 1.2 | 2.0 | 2.0 | 1.0 |
| The vine extract | 2.5 | 3.0 | 4.0 | 3.2 | 3.0 | 4.5 | 5.0 | 2.0 |
| Fruit oligose | 2.0 | 3.0 | 4.0 | 2.5 | 1.5 | 3.5 | 4.0 | 1.0 |
| Vitamin B5 | 0.5 | 0.9 | 1.0 | 0.7 | 0.7 | 0.8 | 1.0 | 0.5 |
| Herba Centellae extract | 0.6 | 0.8 | 0.9 | 0.5 | 0.3 | 0.7 | 0.9 | 0.2 |
| The rice chaff extract | 0.5 | 1.0 | 1.2 | 0.8 | 0.5 | 1.0 | 1.3 | 0.2 |
| Yeast extract | 0.6 | 0.6 | 0.8 | 0.5 | 0.5 | 0.6 | 0.8 | 0.5 |
| Betanin | 1.5 | 1.5 | 1.5 | 1.0 | 1.0 | 1.5 | 2.0 | 1.0 |
| Polyglutamic acid | 0.15 | 0.20 | 0.25 | 0.15 | 0.1 | 0.20 | 0.25 | 0.01 |
| Hyaluronate sodium | 0.08 | 0.06 | 0.08 | 0.05 | 0.05 | 0.08 | 0.1 | 0.05 |
| Beta glucan | 0.5 | 0.5 | 0.6 | 0.3 | 0.3 | 0.4 | 0.6 | 0.1 |
| Trehalose | 1.2 | 1.1 | 1.3 | 1.0 | 1.0 | 1.3 | 1.5 | 1.0 |
| The C phase materials: | ? | ? | ? | ? | ? | ? | ? | ? |
| Glycyrrhizic acid dipotassium | 0.7 | 0.8 | 0.9 | 0.6 | 0.6 | 0.9 | 1.0 | 0.5 |
| Carbamide | 3.0 | 4.0 | 4.5 | 2.5 | 2.5 | 4.5 | 6.0 | 2.0 |
| The D phase materials: | ? | ? | ? | ? | ? | ? | ? | ? |
| Sodium taurocholate | 2.2 | 2.5 | 2.6 | 2.0 | 1.4 | 2.6 | 3.0 | 1.0 |
| Bright string coccus/Radix Raphani root tunning filtrate | 2.2 | 2.4 | 2.5 | 2.0 | 2.0 | 2.3 | 2.5 | 2.0 |
Wherein: in compositions 1～4, the alpha-glucans oligosaccharide degree of polymerization is 3, the fruit oligose degree of polymerization is 2, the beta glucan degree of polymerization is 3; In compositions 5,6, the alpha-glucans oligosaccharide degree of polymerization is 2, the fruit oligose degree of polymerization is 4, the beta glucan degree of polymerization is 3; In compositions 7, the alpha-glucans oligosaccharide degree of polymerization is 5, the fruit oligose degree of polymerization is 3, the beta glucan degree of polymerization is 4; In compositions 8, the alpha-glucans oligosaccharide degree of polymerization is 3, the fruit oligose degree of polymerization is 3, the beta glucan degree of polymerization is 5.
According to the preparation of formula shown in table 2 compositions 1～8, preparation method is as follows:
1) the A phase materials is added in the water pot, be heated to 81 ℃～84 ℃, be incubated sterilizing in 25～35 minutes;
2) treat that the A phase materials is cooled to 36 ℃～40 ℃, mix with the B phase materials, join in the emulsifying pot, stir;
3) treat that in the emulsifying pot, temperature of charge is down to 35 ℃～38 ℃, add the C phase materials, stir;
4) treat that in the emulsifying pot, temperature of charge is down to 28 ℃～32 ℃, add the D phase materials, the rear discharging that stirs, obtain.
test example 1
external (in vitro) test
Compositions 1,2,3 is acted on to the skin microorganism of In vitro culture, verify its regulating action to the skin microorganism.
Test method is as follows: (1) is inoculated in nutrient broth medium (pharmacopeia) by staphylococcus epidermidis (ATCC12228) respectively, staphylococcus aureus (ATCC6538) is inoculated in nutrient broth medium (pharmacopeia), and propionibacterium acnes (ATCC6919) is inoculated in the GAM culture fluid.(2) every kind of culture fluid got 10mL, each 4 parts, adds respectively compositions and the 0.1mL deionized water (blank) of 0.1mL compositions 1,2,3.(3) then staphylococcus epidermidis, staphylococcus aureus are placed in to 37 ℃ of aerobic cultivations of lower 24h, propionibacterium acnes are placed in to 37 ℃ of lower 48h anaerobism and cultivate.(4) measure with dilution-plate method the number of cultivating various bacterium in the culture fluid of front and back.Measurement result is as shown in table 3.
Table 3 is cultivated front and back skin microorganism count relatively (cfu/ml)
Known according to table 3 data, the present composition can effectively promote skin to reside probiotic bacteria (take staphylococcus epidermidis as representative) propagation, and it is inhibited in harmful bacteria (take staphylococcus aureus as representative) and conditioned pathogen (as propionibacterium acnes) temporarily to skin, thereby make the probiotic bacteria status of having the advantage, promote the skin microecological balance.
test example 2
(in vivo) test in body
1, object of study and test grouping: (1) facial acne patient 60 examples, man's 24 examples, female's 36 examples, 23.6 years old mean age, the requirement patient did not use the outer thing of applying medicinal lotion or ointment in 1 month, and, without other maxillofacial diseases, after being divided into to clean of tri-group: A group clear water of A, B, C at random, patients with acne is coated with aconite composition 1; Be coated with aconite composition 2 after clean of B group clear water; Coated large precious emulsion after clean of C group clear water.Each organizes patient's each clean face of morning and evening every day once, and the test period is 30 days, duration of test, and the inactive other drug of patient and cosmetics, and keep light diet.(2) health adult's 20 examples, count the D group, male 8 examples, and female's 12 examples, 24.0 years old mean age, test method is with the A group.Quantity, size, the red and swollen situation of experimenter's facial acne before and after the record test, and the rear experience of using of observing the skin of respectively organizing the experimenter and paying a return visit the experimenter.
2, sample collection: before test, clean patient's face after 5 minutes with normal saline, use the PBS buffer to soak the sterile cotton swab, in acne lesions district 4cm * 4cm scope, slightly firmly smear from inside to outside, immediately the sterile cotton swab is cut with aseptic after collection, be placed in the centrifuge tube that the aseptic PBS of lmL is housed.After off-test, with same method, in skin lesion improvement district, draw materials.The D group is sampled in experimenter's forehead.
3, inoculated and cultured: with PBS solution, by 10 times of dilution methods, be diluted to 10
-1～10
-66 dilution factors, get each dilution solution 0.0lmL, is inoculated in the TYG(propionibacterium acnes) and the Baird-Parker(staphylococcus aureus) select culture medium, 37 ℃ of 48h anaerobism of TYG are cultivated, 37 ℃ of aerobic cultivations of 24h of Baird-Parker.
4, antibacterial isolation identification: 3～5 bacterium colonies of picking from TYG, carry out the biochemical trait analysis with the micro biochemical plate, identify bacterial strain, and use propionibacterium acnes (ATCC6919) to do parallel check experiment.
Before and after test, each organizes experimenter's facial acne propionibacterium and the staphylococcus aureus viable count compares in Table 4.
Table 4 experimenter facial acne propionibacterium and the comparison of staphylococcus aureus count plate (
± s, cfu/cm
2)
As can be seen from Table 4: before and after the test of C group, propionibacterium acnes and staphylococcus aureus viable count are without significant change; After A, B group is tested and before test, compare, propionibacterium acnes and staphylococcus aureus all reduce in various degree, and the skin acne propionibacterium after treatment and staphylococcus aureus viable bacteria number and Healthy People are approaching.Above result shows, the present composition has obvious inhibitory action to propionibacterium acnes and staphylococcus aureus.
On probation after 30 days, A, B organize most of patient (16 people) acne and disappear, but leave pigmentation in various degree, 4 people's acnes reduce, skin lesion district redness alleviates, and continues to use the present composition after 1 month, without new acne, occurs, wherein most people's pigmentation is desalinated gradually, and total cure rate surpasses 80%; C group patient only has 2 people's acnes to disappear, and 3 people's acnes reduce, skin lesion district redness alleviates, and 11 people's symptoms have no improvement, and 4 people's acnes increase, sx↑; A, B, D group experimenter face are showed no the side effect such as xerosis cutis, sensation of pricking, inflammation, and after the experimenter estimates and uses the present composition, skin is soft and moistening, and the colour of skin has improvement in various degree.
Claims (8)
1. the compositions that can promote the skin microecological balance, it comprises following component: the beta glucan that glycerol, butanediol, Radix Hamamelidis Mollis extract, allantoin, EDTA trisodium, glycine, Herba portulacae extract, alpha-glucans oligosaccharide, xylitol, vine extract, fruit oligose, vitamin B5, Herba Centellae extract, rice chaff extract, yeast extract, betanin, polyglutamic acid, hyaluronate sodium, the degree of polymerization are 3～5, trehalose, glycyrrhizic acid dipotassium, carbamide, sodium taurocholate, bright string coccus/Radix Raphani root tunning filtrate.
2. compositions according to claim 1, it is characterized in that: the degree of polymerization of alpha-glucans oligosaccharide is 2～5, the degree of polymerization of fruit oligose is 2～4.
3. compositions according to claim 1, it is characterized in that: yeast extract derives from saccharomyces cerevisiae.
4. according to the described compositions of claim 1～3 any one, it is characterized in that: count by weight, said composition comprises following component:
The A phase materials:
26.0～71.0 parts of deionized waters,
6.0～12.0 parts of glycerol,
5.0～11.0 parts of butanediols,
2.0～5.0 parts of Radix Hamamelidis Mollis extracts,
0.05～0.15 part of allantoin,
0.03～0.05 part of EDTA trisodium;
The B phase materials:
1.0～4.0 parts of glycine,
2.0～5.0 parts of Herba portulacae extracts,
0.5～4.5 part of alpha-glucans oligosaccharide,
1.0～2.0 parts of xylitol,
2.0～5.0 parts of vine extracts,
1.0～4.0 parts of fruit oligoses,
0.5～1.0 part of vitamin B5,
0.2～0.9 part of Herba Centellae extract,
0.2～1.3 part of rice chaff extract,
0.5～0.8 part of yeast extract,
1.0～2.0 parts of betanins,
0.01～0.25 part of polyglutamic acid,
0.05～0.10 part of hyaluronate sodium,
0.1～0.6 part of beta glucan,
1.0～1.5 parts of trehaloses;
The C phase materials:
0.5～1.0 part of glycyrrhizic acid dipotassium,
2.0～6.0 parts, carbamide;
The D phase materials:
1.0～3.0 parts of sodium taurocholates,
Bright string coccus/2.0～2.5 parts of Radix Raphani root tunning filtrates.
5. compositions according to claim 4 is characterized in that: meter by weight comprises following component:
The A phase materials:
36.0～61.0 parts of deionized waters,
6.0～10.0 parts of glycerol,
7.0～10.0 parts of butanediols,
2.0～5.0 parts of Radix Hamamelidis Mollis extracts,
0.08～0.12 part of allantoin,
0.03～0.05 part of EDTA trisodium;
The B phase materials:
1.0～4.0 parts of glycine,
2.0～5.0 parts of Herba portulacae extracts,
2.0～4.5 parts of alpha-glucans oligosaccharide,
1.0～2.0 parts of xylitol,
3.0～5.0 parts of vine extracts,
1.5～4.0 parts of fruit oligoses,
0.7～1.0 part of vitamin B5,
0.2～0.9 part of Herba Centellae extract,
0.5～1.3 part of rice chaff extract,
0.5～0.8 part of yeast extract,
1.0～1.5 parts of betanins,
0.10～0.25 part of polyglutamic acid,
0.05～0.08 part of hyaluronate sodium,
0.3～0.6 part of beta glucan,
1.0～1.3 parts of trehaloses;
The C phase materials:
0.6～0.9 part of glycyrrhizic acid dipotassium,
2.5～4.5 parts, carbamide,
The D phase materials:
1.4～2.6 parts of sodium taurocholates,
Bright string coccus/2.0～2.5 parts of Radix Raphani root tunning filtrates.
6. compositions according to claim 4 is characterized in that: meter by weight comprises following component:
The A phase materials:
43.03 parts of deionized waters,
8.5 parts of glycerol,
9.0 parts of butanediols,
4.5 parts of Radix Hamamelidis Mollis extracts,
0.08 part of allantoin,
0.03 part of EDTA trisodium;
The B phase materials:
3.0 parts of glycine,
4.0 parts of Herba portulacae extracts,
4.0 parts of alpha-glucans oligosaccharide,
1.5 parts of xylitol,
3.0 parts of vine extracts,
3.0 parts of fruit oligoses,
0.9 part of vitamin B5,
0.8 part of Herba Centellae extract,
1.0 parts of rice chaff extracts,
0.6 part of yeast extract,
1.5 parts of betanins,
0.20 part of polyglutamic acid,
0.06 part of hyaluronate sodium,
0.5 part of beta glucan,
1.1 parts of trehaloses;
The C phase materials:
0.8 part of glycyrrhizic acid dipotassium,
4.0 parts, carbamide,
The D phase materials:
2.5 parts of sodium taurocholates,
Bright string coccus/2.4 parts of Radix Raphani root tunning filtrates.
7. the described a kind of preparation method that promotes the compositions of skin microecological balance of claim 1～6 any one comprises the following steps:
1) the A phase materials is added in the water pot, be heated to 81 ℃～84 ℃, insulated sterilizing;
2) treat that the A phase materials is cooled to 36 ℃～40 ℃, mix with the B phase materials, join in the emulsifying pot, stir;
3) treat that in the emulsifying pot, temperature of charge is down to 35 ℃～38 ℃, add the C phase materials, stir;
4) treat that in the emulsifying pot, temperature of charge is down to 28 ℃～32 ℃, add the D phase materials, rear discharging stirs.
8. preparation method according to claim 7, is characterized in that: step 1) insulation sterilizing in 25～35 minutes.
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Address after: 518057, No. 7, No. 1, Nanshan District science and technology, Guangdong, Shenzhen Applicant after: SHENZHEN RONGDA BIOTECHNOLOGY CO., LTD. Address before: 518057, No. 7, No. 1, Nanshan District science and technology, Guangdong, Shenzhen Applicant before: Shenzhen Gene Biological Technology Co., Ltd. |
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Address after: 518000 10a, B and C, building 8, qiaochengfang, No. 4080, Qiaoxiang Road, Gaofa community, Shahe street, Nanshan District, Shenzhen, Guangdong Patentee after: Shenzhen Rongda Biotechnology Co.,Ltd. Address before: No.7, Keji Zhongyi Road, Nanshan District, Shenzhen City, Guangdong Province Patentee before: SHENZHEN RONGDA BIOTECHNOLOGY Co.,Ltd. |