CN109172399A - A kind of acne-removing and skin-clearing composition - Google Patents
A kind of acne-removing and skin-clearing composition Download PDFInfo
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Abstract
The present invention relates to a kind of acne-removing and skin-clearing compositions, are related to cosmetic technical field.It is formed including following raw material: hydrolyzed soy extract, CORTEX PHELLODENDRI CHINENSE extract, glutinous rehmannia extract, white willow bark extract, Bacillus acidi lactici/pear juice tunning filtrate, neem leaf extract, Baical Skullcap root P.E, houttuynia extract, isopropyl cresol class, Glycolic acid, kuh-seng root extract, decoyl salicylic acid, nonanedioyl Diglycocol potassium, Sodium Ascorbyl Phosphate, niacinamide, beta glucan and water.There are good anti-acne and light print effect, while some auxiliary materials being added can play anti-oxidant, moisturizing, improve the skin effects such as skin activity.
Description
Technical field
The present invention relates to cosmetic technical fields, are specifically related to a kind of acne-removing and skin-clearing composition.
Background technique
Forbid adding any western medicine composition in China, cosmetics to reach anti-acne purpose, is applied to dispel at present on the market
The raw material of acne pertain only to mostly with a kind of effect of anti-acne, such as common on the market wash one's face at present with tartaric acid is as main component
Cream, main component is that cutin peels off, for another example with azelaic acid and its derivative skin-protection product as main component, main function
Oil-control, sterilization, the skin-protection product to circulate on the market at present, only exist it is minimal amount of for anti-acne, light print, multiple sides such as skin care
There is effective mechanism of action in face, and in practice with the product of good result.
Acne refers to acne, i.e. a kind of chronic inflammatory skin of pilosebaceous unit in cosmetic industry, main good
It sends out in teenager, alias " whelk ", belongs to sebaceous glands sweat gland disease scope, be broadly divided into acne vulgaris, polymerism in classification
Acne, excessive androgen acne and acne fulminans.
1, acne vulgaris: hebetic men and women is common, is apt to occur in face, followed by chest, back, and sebum secretion is more,
Skin lesion is Whiteheads, blackhead, then forms inflammation red pimple, and purulence head occurs in top sometimes, is formed after ulceration absorption
Pigmentation and small concavity scar, the big inflammation tubercle of the visible beans of serious person or tumour, the size of various damages and deep mixed；
2, acne conglobata: the severe acne occurred on scar acne constitution human body.In morbidity evening, no alleviation process, the course of disease can
Up to the several years to many decades, it is apt to occur in young man, skin lesion is apt to occur in face, neck, back, forearm, waist and buttocks.Skin lesion is often
Double end and the big acne of bull have the purulence ulcer, tumour, the purulent secretion for flowing out stench of tunnel, damage multiple, formation scar
Acne sample patch often includes perifolliculitis capitis abscedens et suffodiens, suppurative hidradenitis, and when blood test is often accompanied by high ball
Proteinemia, IgM, IgG(kinds of immunoglobulins, the participation cell of humoral immunity are changed into P cell by bone-marrow-derived lymphocyte activation
And generate.IgM is that human body is infected the earliest immunoglobulin of generation, it is often used as the detection of early infection,
IgG then generates later, is often used for infecting the index of later period or previous infection.) increase, cellular immunity is low.
3, excessive androgen acne: refer to and aggravate before menstruation polycystic ovary syndrome and the moon or adult Delayed onset or Persistent Acne of Different are suffered from
Person, bibliography Zhao Xiao autumn et al. measure 1 levels in female patients with acne serum sex hormone level after puberty, and discovery testosterone is significantly raised, and female two
Alcohol is substantially reduced with lutropin, shows that Tardive ance is related to the raising of testosterone.It is apt to occur in women, is controlled generally conventional
It is invalid to treat.The course of disease continued to 30-40 years old.Facial hypersteatosis, pachylosis, pore are big, there is hoary hair, blackhead, with
Based on inflammation papule, with tubercle, tumour, ulceration, there is pyorrhea and form scar, sometimes visible crinosity, androgens psilosis, menstruation
Cycle disorder, nasolabial groove and wing of nose two sides continue sexflush, and skin is manlike.
4, acne fulminans: being that immune response caused by propionibacterium acnes or application Tretinoin treatment acne cause skin lesion.
Mainly acute attack, fever up to 38-39 DEG C, have general malaise, anaemia, weight loss, muscle, bone, arthralgia and
Anorexia, skin lesion are mainly shown as Cystic ulcer, the inflammatory tubercle of pain and tumour.The skin lesion of still visible acne vulgaris.
It is several different onset mechanism of acne above, in China, cosmetics are had to comply with meets for addition western medicine composition
National standard.Current anti-acne raw material major part existing on the market both for above one or two kinds of symptoms, for
In the observation of anti-acne effect, there is no reliable effect for acne caused by many reasons, the Western medicine pair currently used for treating acne is made
With huge and be easier to rebound, novel laser therapy method, microorganism is quickly killed, inhibits bacterial reproduction, but deposit in effect
It is short in timeliness, the characteristics of easily rebound.
Summary of the invention
In order to overcome the shortcomings of that background technique, the present invention are provided acne-removing and skin-clearing composition, matched using Chinese medical extract
5, meet requirement of the state's laws regulation to cosmetic composition, can achieve the effect that acne-removing and skin-clearing.
In order to achieve the above-mentioned object of the invention, the technical solution adopted in the present invention:
A kind of acne-removing and skin-clearing composition, is made of raw material from the following weight: 5~12 parts of hydrolyzed soy extract, CORTEX PHELLODENDRI CHINENSE mention
Take 5~12 parts of object, 5~12 parts of glutinous rehmannia extract, 5~12 parts of white willow bark extract, Bacillus acidi lactici/pear juice tunning filtrate
2~8 parts, 5~12 parts of neem leaf extract, 7~16 parts of water, 5~12 parts of Baical Skullcap root P.E, 5~12 parts of houttuynia extract,
1~3 part of isopropyl cresol class, 0.3~1.4 part of Glycolic acid, 5~12 parts of kuh-seng root extract, 0.3~1.4 part of decoyl salicylic acid,
1~3 part of nonanedioyl Diglycocol potassium, 2~8 parts of Sodium Ascorbyl Phosphate, 2~8 parts of niacinamide, 2~8 parts of beta glucan.
Preferably, it is made of raw material from the following weight: 7~10 parts of hydrolyzed soy extract, CORTEX PHELLODENDRI CHINENSE extract 7~10
Part, 6~10 parts of glutinous rehmannia extract, 6~10 parts of white willow bark extract, Bacillus acidi lactici/4~6 parts of pear juice tunning filtrate, print
Spend 7~10 parts of chinaberry leaf extract, 7~10 parts of Baical Skullcap root P.E, 7~10 parts of houttuynia extract, 1~2 part of isopropyl cresol class,
0.6~1.2 part of Glycolic acid, 7~10 parts of kuh-seng root extract, 0.6~1.2 part of decoyl salicylic acid, nonanedioyl Diglycocol potassium 2
~3 parts, 4~6 parts of Sodium Ascorbyl Phosphate, 4~6 parts of niacinamide, 4~6 parts of beta glucan, 9~13 parts of water.
Preferably, it is made of raw material from the following weight: 8 parts of hydrolyzed soy extract, 8 parts of CORTEX PHELLODENDRI CHINENSE extract, glutinous rehmannia
8 parts of extract, 8 parts of white willow bark extract, Bacillus acidi lactici/5 parts of pear juice tunning filtrate, 8 parts of neem leaf extract, Huang
8 parts of a kind of reed mentioned in ancient books extract, 8 parts of houttuynia extract, 2 parts of isopropyl cresol class, 1 part of Glycolic acid, 8 parts of kuh-seng root extract, decoyl water
Poplar acid 1 part, 2 parts of nonanedioyl Diglycocol potassium, 5 parts of Sodium Ascorbyl Phosphate, 5 parts of niacinamide, 5 parts of beta glucan, 10 parts of water.
CORTEX PHELLODENDRI CHINENSE extract, glutinous rehmannia extract, Baical Skullcap root P.E, houttuynia extract are respectively CORTEX PHELLODENDRI CHINENSE, glutinous rehmannia, Huang
The alcohol extract that the step of a kind of reed mentioned in ancient books, cordate houttuynia extract and purify by organic reagent obtains.CORTEX PHELLODENDRI CHINENSE extract concentrations are 0.125g/
Ml, glutinous rehmannia extract concentration are 0.04 g/ml, Baical Skullcap root P.E concentration is 0.018 g/ml, houttuynia extract concentration is
0.016 g/ml and Baical Skullcap root P.E concentration are 0.018 g/ml.
Hydrolyzed soy extract, neem leaf extract, white willow bark extract and kuh-seng root extract are respectively to hydrolyze
The water extract that the step of soybean, azadirachta leaf radix sophorae, white willow bark and radix sophorae are dissolved and purified by water obtains.
Hydrolyzed soy extract concentrations are that take object, neem leaf extract concentration be 0.02g/ml to 0.008g/ml, white willow
Bark extract concentration is 0.05g/ml and radix sophorae extract concentrations are 0.125g/ml.
The Bacillus acidi lactici/pear juice tunning filtrate is the filtered fluid of tunning, and it is 0.7g/ml that concentration, which is obtained by filtration,
Bacillus acidi lactici/pear juice tunning filtrate.
The beneficial effects of the present invention are: carrying out compatibility using above scheme using Chinese medical extract and compound, forming tool
There is the composition of acne-removing and skin-clearing effect, meets state's laws regulation and dispel to reach to forbidding adding western medicine composition in cosmetic composition
The requirement of acne purpose, while all there is the light print repairing effect of skin to acne caused by a variety of causes in the combination of various composition, mainly
Ingredient is Chinese medical extract, and effect is good, and Small side effects, effect does not rebound, and some auxiliary materials of addition can play anti-oxidant, guarantor
The skin effects such as wet, raising skin activity.
Detailed description of the invention
Fig. 1 is bacteria living quantity schematic diagram after bactericidal effect of the present invention and addition embodiment.
Fig. 2 is that lipase active schematic diagram of the invention is added.
Fig. 3 is the human desmocyte mother cell quantity schematic diagram that various concentration raw material is added.
Fig. 4 is that product of the present invention and kojic acid, ascorbic acid inhibit schematic diagram for the melanin of albumen.
Fig. 5 is with reference to the cell after cell, ultraviolet light irradiation, the cell schematic diagram after the irradiation of feedstock processing ultraviolet light.
Specific embodiment
Below with reference to embodiment and attached drawing, embodiments of the present invention is further illustrated: this part is described as this hair
Bright explanation should not have any restriction effect to protection scope of the present invention.
A kind of acne-removing and skin-clearing composition, is compounded by the raw material of following parts by weight:
5~12 parts of hydrolyzed soy extract, 5~12 parts of CORTEX PHELLODENDRI CHINENSE extract, 5~12 parts of glutinous rehmannia extract, white willow bark extract
5~12 parts of object, Bacillus acidi lactici/2~8 parts of pear juice tunning filtrate, 5~12 parts of neem leaf extract, 7~16 parts of water, Huang
5~12 parts of a kind of reed mentioned in ancient books extract, 5~12 parts of houttuynia extract, 1~3 part of isopropyl cresol class, 0.3~1.4 part of Glycolic acid, kuh-seng
5~12 parts of root extract, 0.3~1.4 part of decoyl salicylic acid, 1~3 part of nonanedioyl Diglycocol potassium, Sodium Ascorbyl Phosphate 2
~8 parts, 2~8 parts of niacinamide, 2~8 parts of beta glucan.
The present invention chooses 11 embodiments, and each embodiment forms shown in following table, and each raw material is parts by weight:
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 | Embodiment 11 | |
| Hydrolyzed soy extract | 8 | 7 | 10 | 5 | 12 | 6 | 8 | 7 | 10 | 5 | 12 |
| CORTEX PHELLODENDRI CHINENSE alcohol extract | 8 | 10 | 7 | 12 | 5 | 11 | 8 | 10 | 7 | 12 | 5 |
| Glutinous rehmannia alcohol extract | 8 | 6 | 10 | 5 | 12 | 5.5 | 8 | 6 | 10 | 5 | 12 |
| White willow severe edema due to hypofunction of the spleen extract | 8 | 10 | 6 | 12 | 5 | 11 | 8 | 10 | 6 | 12 | 5 |
| Bacillus acidi lactici/pear juice tunning filtrate | 5 | 4 | 6 | 2 | 8 | 7 | 5 | 4 | 6 | 2 | 8 |
| Azadirachta leaf water extract | 8 | 10 | 7 | 12 | 5 | 6 | 8 | 10 | 7 | 12 | 5 |
| Radix scutellariae alcohol extract | 8 | 7 | 10 | 5 | 12 | 11 | 8 | 7 | 10 | 5 | 12 |
| Cordate houttuynia alcohol extract | 8 | 10 | 7 | 12 | 5 | 6 | 8 | 10 | 7 | 12 | 5 |
| Isopropyl cresol class | 2 | 2 | 1 | 1 | 3 | 2.5 | 2 | 2 | 1 | 1 | 3 |
| Glycolic acid | 1 | 0.6 | 1.2 | 1.4 | 0.3 | 0.4 | 1 | 0.6 | 1.2 | 1.4 | 0.3 |
| Radix sophorae water extract | 8 | 10 | 7 | 5 | 12 | 11 | - | - | - | - | - |
| Decoyl salicylic acid | 1 | 0.6 | 1.2 | 1.4 | 0.3 | 0.5 | - | - | - | - | - |
| Nonanedioyl Diglycocol potassium | 2 | 3 | 2 | 1 | 3 | 2.2 | - | - | - | - | - |
| Sodium Ascorbyl Phosphate | 5 | 4 | 6 | 8 | 2 | 7 | - | - | - | - | - |
| Niacinamide | 5 | 6 | 4 | 2 | 8 | 3 | - | - | - | - | - |
| Beta glucan | 5 | 4 | 6 | 8 | 2 | 7 | - | - | - | - | - |
| Water | 10 | 13 | 9 | 7 | 16 | 15 | 10 | 13 | 9 | 7 | 16 |
Each section effect is as follows in above-mentioned composition:
1, since acne is to belong to male hormone activation sebaceous glands, and contain FLAVOSTERONE SB in hydrolyzed soy extract
Aminocaproic Acid and glutinous rehmannia the alcohol extract B of Liquid containing JIOU, they can prevent activation sebaceous glands；JIOU Liquid B couple
The active inhibitory effect of testosterone 5- alpha-reductase, it is a kind of enzyme that can activate male hormone, can be inhibited by male
The proliferation of prostate gland cancer cell caused by hormone.
2, after acne occurs, the cutin out-of-sequence hair follicle hole that will cause that falls off is blocked, and contains in Bacillus acidi lactici/pear juice yeast filtrate
Fermentage PEAR B, and contain Dermaveil with white willow severe edema due to hypofunction of the spleen extract, they can dispel cutin to keep pore
It is open；
3, acne bacterium easily causes inflammation, contains OUBAKU Liquid B and azadirachta leaf water in Cortex Phellodendri bark alcohol extract
Contain NEEM Leaf Liquid B in extract, they can be sterilized；
OUBAKU Liquid B is able to suppress the growth of acne bacterium (P.acnes), and minimum inhibitory concentration is only 0.2%.
It is to cause inflammation that NEEM Leaf Liquid B, which can selectively inhibit COX2 in cyclo-oxygenase (COX), COX2,
Principal element, arachidonic acid can be manufactured from impaired cell membrane.
4, concomitant immunity reaction acne runs down and long-term existence, contains DOKUDAMI in houttuynia curdatu leaf alcohol extract
Contain OUGON Liquid B in Liquid B and scutellariae,radix alcohol extract, they can be with anti-oxidant anti-inflammatory；
DOKUDAMI Liquid B inhibits histamine release of mast cell, and histamine is one of the factor for causing inflammation to cause to itch；To
DOKUDAMI Liquid B can dispel the active oxygen in human body neutrophil leucocyte system.
OUGON Liquid B dispels the active oxygen in human body neutrophil leucocyte system, skin texture can be protected from Cuo
Sore is microbial to be immunoreacted the damage brought.
5, synergy is played in acne-removing and skin-clearing composition, anti-oxidant and skin lightening raw material:
5.1, Sodium Ascorbyl Phosphate (stay-c 50), energy anti-acne active, reduces inflammatory damage, and having significantly reduces purple
The formation of the lipid peroxide of outside line induction.
5.2, radix sophorae water extract, nonanedioyl Diglycocol potassium and decoyl salicylic acid, can be to Escherichia coli, green pus bar
Bacterium, Candida albicans, staphylococcus aureus, staphylococcus epidermis and propionibacterium acnes have strong inhibitory effect, therefore
Synergistic function can be played.
5.3, niacinamide-BP the effect of can with do not allow the drug added to compare favourably in regulation, 4% niacinamide and 1% gram
Woods mycin effect is suitable, and does not have side effect completely.
5.4, the effect of beta glucan is to improve the moisture and antiinflammation of skin, and 2% beta glucan is inhibiting mouse ear water
The effect of swelling with 0.5% aspirin is better than in the antiinflammations such as neutrophil cell influx；0.4% beta glucan is in moisturizing
In effect, was acted on through 2 hours, be better than the moisture-keeping function of 0.1% hyaluronic acid.
Niacinamide-the BP that the present invention selects is acute toxicity substance, and strict control niacinamide-BP is lower than in the present invention
2500mg/kg。
Anti-acne, light print, reparation and skin brightness are carried out using above-described embodiment product and promote experiment, as a result as follows:
1, anti-acne effect
1.1, stable activities of microorganisms
The product of inactivation is cultivated in liquid culture medium, in liquid culture medium, uses two kinds of dilution process.With optical density (OD)
(the smog phenomenon that measurement is generated by microorganism growth) and pH value (variation of measurement pH value caused by bacterial activity) are micro- to measure
The growth of biology.Microscope observing time: 1 day, 4 days, 5 days, 6 days, 7 days, the stablizing effect of microorganism: MIC(is minimum antibacterial dense
Degree): thus speculate that the Cmin that the molecule suppresses growth of microorganism is possible.
Above-described embodiment product is detected to the inhibitory effect of propionibacterium acnes acne, is significantly inhibited as shown in Figure 1, having
Effect.
1.2, bactericidal activity
In the exponential phase of bacterial reproduction, and at 7 days of bacterial growth, above-mentioned culture is transferred in a solid medium,
Without using any bacteriostatic agent.It is observed 1 day, 4 days, 5 days, 6 days, 7 days and measures bacterial growth situation in culture dish.Sterilization biology
Effect: CMB(minimum bactericidal concentration): the Cmin for thus speculating that the molecule kills microorganism is possible.
Above-described embodiment product is detected to the insect killing effect of propionibacterium acnes acne, as shown in Figure 1, embodiment is for Cuo
Sore Propionibacterium has significantly insect killing effect.
1.3, the measurement of anti-cellulite enzymatic activity
The measurement of anti-cellulite enzymatic activity can be completed by the enzyme reagent kit of commercialization, and this kit includes pancreatic lipase and its
He plays the mixture of the enzyme of catalytic action, and the activity that this mixture can measure lipase under conditions of there are matrix is strong
Degree.Mix ingredients is as follows:
1,2- diglyceride lipase pancreatin 2- monoglyceride+fatty acid
2- monoglyceride lipase monoglyceride glycerol+fatty acid
Glycerol+ATP Glycerol kinase glycerol -3P+ADP
Glycerol -3P+O2 phosphoglycerol lipoxidase dihydroxyacetone (DHA)-P+H2O2
2H2O2+4 amino-antipyrine peroxidase colorant benzoquinones imidodicarbonic diamide+2H2O2+TOOS
TOOS:N- methyl N-(2 hydroxyl -3- sulfopropyl) -3- toluidines sodium
Using above-mentioned method for testing and detecting, the anti-cellulite enzymatic activity of above-described embodiment product can be measured.These tests are surveyed
Index of the fixed index with common plant tensor (extracting from wheat embryo) anti-cellulite enzymatic activity compares, as a result
As shown in Fig. 2, the curve of peak height is embodiment product, the low curve in peak is common plant tensor；Show that embodiment product exists
Powerful anti-cellulite enzymatic activity is shown when concentration 12%.When between concentration is from 10 to 12%, embodiment product can inhibit 70
To 75% lipase active.Embodiment inhibits lipase active in most concentration range.
1.4, the active measurement of seborrhea
With embodiment product through 12 subjects, after continuous use 35 days, sebum amount reduces 35%, and sebum spillway discharge is reduced
48.8%。
Conclusion:
Embodiment product is mainly to pass through the activity suppression for inhibiting microorganism especially propionibacterium acnes and staphylococcus aureus
The activity of microbial lipase inhibits the inflammation of acne, destroys and acne environment of bacteria growth is caused to reach anti-acne purpose, have and do not hurt
Beneficial bacterium, in one week can removing acne, acne, dark sore, acarid and no dependence, meet wanting for our state's laws regulations
It asks.
2, light print repairing effect
2.1, cell-proliferation activity (MTT test), is tested, result is as shown in Figure 3 with human desmocyte mother cell；Conclusion:
Proliferation activity increases by 57%, (control group: 1% serum).
2.2, testing in vitro
Method: 20 have the patient of acne problems using the present embodiment product, and 3 times a day, light print effect is obvious.
3, skin effects are highlighted
3.1, the functional examination on cellular level
To the inhibiting effect of melanocyte S91: after S91 melanocyte is irradiated with ultraviolet light (30mJ/cm2 and 285mm)
The present embodiment product is added to cultivate 16 hours, then measurement generates the quantity of melanin, and result is as shown in figure 4, show this implementation
Rejection ability of the example product to melanogen.
It is being compared with kojic acid and ascorbic acid as a result, as shown in Figure 5, showing simultaneously under conditions of cell experiment
The present embodiment product, which is added in melanocyte S91, to be had on culture medium existing for DOPA, after ultraviolet light (3*50Mj/cm2) stimulation
Albumen melanin content, the present embodiment can more fully inhibit the melanin content of albumen than kojic acid and ascorbic acid,
There is good inhibition melanin result.
3.2, clinical trial is investigated
After using the present embodiment product four weeks, carry out questionnaire survey, display: experimenter's answer more than half uses this implementation
Feel to improve in the position of example product.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of acne-removing and skin-clearing composition, it is characterised in that: be made of raw material from the following weight: hydrolyzed soy extract 5~
12 parts, 5~12 parts of CORTEX PHELLODENDRI CHINENSE extract, 5~12 parts of glutinous rehmannia extract, 5~12 parts of white willow bark extract, Bacillus acidi lactici/pears
2~8 parts of juice tunning filtrate, 5~12 parts of neem leaf extract, 7~16 parts of water, 5~12 parts of Baical Skullcap root P.E, cordate houttuynia
5~12 parts of extract, 1~3 part of isopropyl cresol class, 0.3~1.4 part of Glycolic acid, 5~12 parts of kuh-seng root extract, decoyl water
0.3~1.4 part of poplar acid, 1~3 part of nonanedioyl Diglycocol potassium, 2~8 parts of Sodium Ascorbyl Phosphate, 2~8 parts of niacinamide, β-
2~8 parts of glucan.
2. a kind of acne-removing and skin-clearing composition according to claim 1, it is characterised in that: by the raw material system of following raw material part
At: 7~10 parts of hydrolyzed soy extract, 7~10 parts of CORTEX PHELLODENDRI CHINENSE extract, 6~10 parts of glutinous rehmannia extract, white willow bark extract
6~10 parts, Bacillus acidi lactici/4~6 parts of pear juice tunning filtrate, 7~10 parts of neem leaf extract, Baical Skullcap root P.E 7~10
Part, 7~10 parts of houttuynia extract, 1~2 part of isopropyl cresol class, 0.6~1.2 part of Glycolic acid, kuh-seng root extract 7~10
Part, 0.6~1.2 part of decoyl salicylic acid, 2~3 parts of nonanedioyl Diglycocol potassium, 4~6 parts of Sodium Ascorbyl Phosphate, niacinamide
4~6 parts, 4~6 parts of beta glucan, 9~13 parts of water.
3. a kind of acne-removing and skin-clearing composition according to claim 2, it is characterised in that: by the raw material system of following raw material part
At: 8 parts of hydrolyzed soy extract, 8 parts of CORTEX PHELLODENDRI CHINENSE extract, 8 parts of glutinous rehmannia extract, 8 parts of white willow bark extract, lactic acid bar
Bacterium/5 parts of pear juice tunning filtrate, 8 parts of neem leaf extract, 8 parts of Baical Skullcap root P.E, 8 parts of houttuynia extract, isopropyl
2 parts of cresols class, 1 part of Glycolic acid, 8 parts of kuh-seng root extract, 1 part of decoyl salicylic acid, 2 parts of nonanedioyl Diglycocol potassium, Vitamin C
5 parts of acid phosphoric acid ester sodium, 5 parts of niacinamide, 5 parts of beta glucan, 10 parts of water.
4. a kind of acne-removing and skin-clearing composition according to claim 3, it is characterised in that: the CORTEX PHELLODENDRI CHINENSE extract, glutinous rehmannia
Extract, Baical Skullcap root P.E, houttuynia extract be respectively CORTEX PHELLODENDRI CHINENSE, glutinous rehmannia, radix scutellariae, cordate houttuynia by organic reagent extraction and
The alcohol extract that the step of purification obtains.
5. a kind of acne-removing and skin-clearing composition according to claim 4, it is characterised in that: the CORTEX PHELLODENDRI CHINENSE extract concentrations are
0.125g/ml, glutinous rehmannia extract concentration are 0.04 g/ml, Baical Skullcap root P.E concentration is 0.018 g/ml, houttuynia extract is dense
Degree is 0.016 g/ml and Baical Skullcap root P.E concentration is 0.018 g/ml.
6. a kind of acne-removing and skin-clearing composition according to claim 3, it is characterised in that: the hydrolyzed soy extract, print
Spending chinaberry leaf extract, white willow bark extract and kuh-seng root extract is respectively hydrolyzed soy, azadirachta leaf radix sophorae, white willow
The water extract that the step of skin and radix sophorae are dissolved and purified by water obtains.
7. a kind of acne-removing and skin-clearing composition according to claim 6, it is characterised in that: the hydrolyzed soy extract concentrations
Taking object, neem leaf extract concentration for 0.008g/ml is 0.02g/ml, white willow bark extract concentration is 0.05g/ml and hardship
Ginseng root extract concentration is 0.125g/ml.
8. a kind of acne-removing and skin-clearing composition according to claim 3, it is characterised in that: the Bacillus acidi lactici/pear juice fermentation
Product filtrate is the filtered fluid of tunning, and Bacillus acidi lactici/pear juice tunning filtrate that concentration is 0.7g/ml is obtained by filtration.
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| CN201811241658.6A CN109172399A (en) | 2018-10-24 | 2018-10-24 | A kind of acne-removing and skin-clearing composition |
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| CN110613658A (en) * | 2019-10-09 | 2019-12-27 | 广州市玉鑫化妆品有限公司 | Acne-removing compound preparation and preparation method thereof |
| CN111388405A (en) * | 2020-05-26 | 2020-07-10 | 广州雅纯化妆品制造有限公司 | Oil-control acne-removing composition |
| CN111514053A (en) * | 2019-11-06 | 2020-08-11 | 广州妮趣化妆品有限公司 | Composition with acne removing effect and preparation method and application thereof |
| CN111658590A (en) * | 2020-07-15 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Acne-removing composition and application thereof |
| CN115350126A (en) * | 2022-08-23 | 2022-11-18 | 陕西慧康生物科技有限责任公司 | Composition containing salicylic acid and having mild oil-controlling and acne-removing effects and application thereof |
| CN115381727A (en) * | 2022-09-27 | 2022-11-25 | 广州森野生物医药科技有限公司 | Whitening and freckle removing composition and preparation method thereof |
| CN115670998A (en) * | 2022-11-18 | 2023-02-03 | 广州澳莱娜生物科技有限公司 | Acne-removing, oil-controlling and skin-brightening composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613658A (en) * | 2019-10-09 | 2019-12-27 | 广州市玉鑫化妆品有限公司 | Acne-removing compound preparation and preparation method thereof |
| CN111514053A (en) * | 2019-11-06 | 2020-08-11 | 广州妮趣化妆品有限公司 | Composition with acne removing effect and preparation method and application thereof |
| CN111514053B (en) * | 2019-11-06 | 2023-02-07 | 广州妮趣化妆品有限公司 | Composition with acne removing effect and preparation method and application thereof |
| CN111388405A (en) * | 2020-05-26 | 2020-07-10 | 广州雅纯化妆品制造有限公司 | Oil-control acne-removing composition |
| CN111388405B (en) * | 2020-05-26 | 2021-08-17 | 广州雅纯化妆品制造有限公司 | Oil-control acne-removing composition |
| CN111658590A (en) * | 2020-07-15 | 2020-09-15 | 泉后(广州)生物科技研究院有限公司 | Acne-removing composition and application thereof |
| CN115350126A (en) * | 2022-08-23 | 2022-11-18 | 陕西慧康生物科技有限责任公司 | Composition containing salicylic acid and having mild oil-controlling and acne-removing effects and application thereof |
| CN115350126B (en) * | 2022-08-23 | 2024-03-26 | 陕西慧康生物科技有限责任公司 | Mild salicylic acid-containing composition with oil control and acne removal effects and application thereof |
| CN115381727A (en) * | 2022-09-27 | 2022-11-25 | 广州森野生物医药科技有限公司 | Whitening and freckle removing composition and preparation method thereof |
| CN115670998A (en) * | 2022-11-18 | 2023-02-03 | 广州澳莱娜生物科技有限公司 | Acne-removing, oil-controlling and skin-brightening composition and preparation method thereof |
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