KR101464914B1 - Composition for curing acne with skin barrier reinforcement and skin cell regeneration and method for manufacturing the same - Google Patents

Abstract

The present invention provides a composition comprising natural medicinal herbal extracts and natural organic sulfur as major active ingredients for enhancing skin functions, regenerating skin cells, and treating acne at the same time without having side effects to the human body. The composition of the present invention contains a herbal mixture extract extracted by mixing Scutellaria baicalensis, Phellodendron amurense, Gardenia jasminoides, and Portulaca oleracea, a Sophora flavescens extract, a Coptis chinensis extract, a Poria cocas extract, and natural organic sulfur.

Description

Technical Field [0001] The present invention relates to a composition for treating acne by reinforcing skin barrier and cell regeneration, and a method of manufacturing the same.

The present invention relates to a composition for treating acne by strengthening skin barrier and cell regeneration, and more particularly, to a composition for treating acne by extracting an active ingredient using 1,3-butylene glycol, which is a kind of alcohol, ≪ / RTI >

In general, acne is one of the most common skin diseases that afflicts 80% of people aged 11-30 years, for whatever reason. These acne are caused by abnormalities of the sebaceous glands. Excess sebum and squamous epithelium block the sebaceous glands to form black head or whitehead, and the sebaceous glands that block the tube become an environment in which anaerobic bacteria can grow well, and inflammation starts by the reaction of the immune system.

Experimentally, acne has a weak skin barrier and regeneration of skin cells long before it occurs, resulting in excess of keratinocytes in the skin, resulting in excessive secretion of sweat glands and sebaceous glands, resulting in sebum and dead skin cells that have not been released into the pores .

When these skin conditions last for a long time, anaerobic bacteria gradually grow, and sebaceous glands accumulate in the pores. If the food is abundant, the bacterial population rapidly increases, and the bacterial excrement causes acne.

In general, acne is caused by the use of antibiotics and fat absorption as a medicine to inhibit the absorption of isotretinoin (Rojakutan) is a drug at the beginning of a very mysterious acne will disappear, but the underlying cause of acne can remain because 1 After 2 weeks, acne will occur again. After taking the medicine again, the number of times the medicine is taken increases the resistance of the bacteria, no longer responds to the antibiotics, and conversely, the physiological functions of the skin are getting weaker and the bacteria become more environmentally friendly, And the depth of the enrichment becomes deeper.

Due to these side effects, it is required to develop a therapeutic agent based on a natural medicinal substance which can enhance skin barrier function, regenerate skin cells and treat acne diseases.

Korean Patent Registration No. 10-1212346

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to overcome the above-mentioned problems of the prior art, and it is an object of the present invention to provide a natural medicinal herb extract and natural organic sulfur as main active ingredients, And to provide a composition capable of treating acne diseases at the same time as regenerating skin cells.

In order to achieve the above object, the present invention provides a composition for treating acne by enhancing skin barrier and cell regeneration, comprising a mixture of a herbal medicine extract, a ginseng extract, a Huanghui extract, And a natural organic sulfur.

 Also, in the present invention, the herbal medicines-mixed extract, the ginseng extract, the Rhodiola extract and the Baekbokryeong extract are extracted using 1,3-butylene glycol as an extraction solvent.

In a preferred embodiment, the extracts can be extracted by immersing in the extraction solvent at room temperature for 100 days.

In addition, the composition of the present invention may further contain niacinamide, D-panthenol, and triethyl citrate.

In a preferred embodiment of the present invention, the composition of the present invention comprises 8% by weight of the herbal medicine mixed extract, 6% by weight of the ginseng extract, 2% by weight of the Rhodiola extract, 4% 10% by weight of amide, 4% by weight of D-panthenol and 16% by weight of triethyl citrate.

In addition, as the embodiment of the herbal medicine mixed extract, the mixture ratio of gold, yellow whites, gypsum and marjoram is preferably 1: 1: 1: 1 by weight.

 In a preferred embodiment of the present invention, the composition of the present invention can be formulated as a cosmetic preparation or a preparation for preventing or treating acne.

 Formulations of the cosmetic for preventing or treating acne include various creams, cleansing foams, whole body cleansers, soaps, packs, cosmetics and the like, such as skins, lotions, essences, nutritional creams, massage creams and cleansing creams containing the composition of the present invention as an active ingredient. A skin adhesive patch, a skin adhesive gel, a powder, a foundation, and the like.

 The formulations for preventing or treating acne include parenteral administration agents such as tablets and capsules containing the composition of the present invention as an active ingredient, oral administration agents, injections, patches, ointments, lotions and creams . ≪ / RTI >

According to the present invention, by containing natural herbal medicine extract and natural organic sulfur as main active ingredients, it is possible to stably and continuously use various side effects such as the following, which can occur in the human body, .

Particularly, the composition of the present invention can be used for the treatment of oral acne, which can cause 1) red and dry lips, 2) blurred vision, dryness of eyes, 3) dizziness, 4) nausea and vomiting, 5) 6) loss of hearing ability, tinnitus, 7) skin keratinization, 8) hair loss symptoms, 9) adverse effects such as birth defects when taking pregnant women.

According to the present invention, proliferation of acne bacterium is prevented, and sebaceous and keratinous production is suppressed, whereby skin function improvement and skin cell regeneration are excellent.

Further, according to the present invention, by using 1,3-butylene glycol as an extraction solvent, it is possible to effectively extract a herbal medicine ingredient which is not soluble in water.

1 is a photograph showing the results of Experimental Example 3;

In the following, a preferred embodiment of the present invention will be described, but it should be understood that the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

The composition for treating acne by strengthening skin barrier and cell regeneration comprises a mixed extract of herbal medicines mixed with gold, yellow whites, gypsum and mashin, a ginseng extract, a Huangryu extract, and a Baekbokryeong extract.

In the present invention, the mixed extract of herbal medicines is mixed with herbal medicines of golden, yellow, white, gypsum and mashishi and is dipped in 1,3-butylene glycol at room temperature for a certain period of time to extract an active ingredient.

Scutellaria baicalensis Georgi is a medicinal plant which is used as an antipyretic, diuretic, branching, insecticide and antiinflammatory agent and has excellent antimicrobial activity. In the case of copper therapy, scutellaria baicalensis georgi is an inflammatory drug, It is also used for diseases with [sapphire detoxification and cleansing heat (淸热 濕濕) efficacy].

Golden roots contain baicalein, baicalin, wogonin, wogonoside, neobaicalein, benzoic acid, and stem and leaves contain scutellarin.

1) Bailcalein and Wogonoside are antimicrobial and antiviral. Baiclin and Wogonin inhibit vascular permeability and alleviate swelling and suppress chronic inflammation (antiinflammatory and antihypertensive). Its mechanism is to inhibit the secretion of histamine And inhibit the metabolism of arachidonic acid.

  2) Suppress skin irritation. The antiallergic action of Baicalin and Baicalein inhibited the activity of SH-enzyme and inhibited anapalacic transporter.

3) It acts lipid lowering effect. Flavonoid compounds, the major component of gold, reduce blood lipid levels. It also has antioxidant action.

4) It stimulates cell immune response. The IL-2 in the body is an important index reflecting immune regulation. The golden extract promotes the production of IL-2.

Among the components of the herbal medicinal herb extract, red beans are also called dried beech peonies, which are dried in the rutaceae and belong to the family Phellodendron amurense Rupr. Its efficacy is used for conjunctivitis, diarrhea, chronic colitis and bacterial proliferation. It is used for inflammation (swelling or swelling), pneumonia, bone tuberculosis, cold, sterilization, And it is also used as a useful medicinal herb.

Gardenia jasminoides is an evergreen shrub belonging to the family Rubiaceae. Its main components are Gardenoside, Geniposide, and Shanzhiside. The main effects of the gardenia are the heat of the human body and the antimicrobial and antiviral action, which has an excellent pharmacological effect for the improvement of facial skin diseases such as stain removal and acne. More specifically, gardenia is a typical medicinal herb that reduces heat in the body. It not only inhibits the growth of skin fungi but also has an anti-inflammatory action and alcoholic and anti-inflammatory action.

Among the components of the herbal medicine mixed extract component, mashin is the outpast of Portulaca oleracea L., and it contains polysaccharide with excellent moisturizing property and various amino acids, so that it has excellent antipyretic action and detoxifying action, To relieve dryness of the skin. It is effective for anti-inflammation and skin soothing, and is effective for atopy and acne, and also promotes hair growth.

In the gosam extract of the present invention, Sophora flavescens Aiton is a perennial herb with rosemary roots of the dicotyledonous plant, and is also called gosam. In one room, dried roots are called ginseng, and they are flavored as herbal medicine described in Korean Pharmacopoeia and have the efficacy of ginseng, prescribing them for indigestion, neuralgia, hepatitis, jaundice, hemorrhoids. In the private sector, it is also used as an insecticide by dying stem or leaf. The main ingredients are Matrine and Oxymatrine, both of which have an anti-inflammatory effect.

In the extract of Coptis chinensis, Coptis chinensis is an evergreen perennial herb which has the following function.

1) Antibacterial action: intestinal overgrowth caused by intestinal fatigue There is an efficacy to treat various skin diseases. The Berberin component of Huanglian has broad antibacterial activity.

2) Antiviral action: Beryline of HuangYin has been proved to directly inhibit various epidemic viruses.

3) Detoxification Action: Bacterial toxin is a factor that damages various tissues during infection. Berberine ingredient inhibits the toxin of pathogenic microorganism and improves the toxicity. It decreases bacterial toxicity, thus enhancing the phagocytic ability of the phagocytic cells.

4) Antiinflammatory and bio-defense function: The alcohol extract of Rhodiola is effective in inhibiting the swelling of the mice induced by the rat, and Berberine is effective for acute inflammation. It enhances the ability of leukocyte and reticuloendothelial phagocytosis in the body to improve its defense against inflammation.

In the extract of Baekbokryeong of the present invention, Baekbokryeong is dried sclerot of Poria cocas Wolf. It grows and grows in the place where pine trees of all over the country are cut. It grows like a lump in the pine roots that have been bloomed for many years. It is roughly 30 ~ 50㎝ in diameter, rough like a pine bark on the outside and white or pink inward. White is white rosette and pink rosy is red rooster. Baek Bok-gyeong is parasitized in the roots of red pine. And, the thing surrounding the solitary root is called the dupe.

The main component of Baekbokryeong contains β-Pachyman, which accounts for about 93% of dry weight. In addition, it contains Chitin, Protein, Fat, Sterol, Lecithin, Glucose, Adenin, Histidine, Choline, β-Pachymanase, Lipase and Protease and has excellent efficacy on cancer suppression, stomach, stomach, pancreas and kidney . It has long been used as a tonic. Pharmacological experiments have shown that diuretic action, lowering blood sugar level, sedation and so on.

Meanwhile, MSM (Methy Sulfonyl Methane), which is a main active ingredient of the present invention, is a non-toxic and odorless sulfur extracted from plants and is a water-soluble white powder of 99.9% of Dimethy Sulfone.

The effects of natural organic sulfur are as follows.

1) Detoxifies harmful substances deposited in skin tissue (keratin-epidermis).

The sulfur amino acid cysteine (Cystine), which is the main component of the keratin protein structure, is responsible for detoxifying toxic substances accumulating in the skin tissue during environmental pollution. Therefore, the sulfur component further improves the keratin function of the skin tissue, thereby rapidly cleansing and detoxifying accumulated harmful substances on the skin.

2) It keeps elasticity of skin tissue (collagen).

Whether the skin is elastic or not is in the functionality of collagen, the dermal layer. Collagen molecules are the most abundant proteins in the human body and have a triple helix structure, which maintains high stability. The collagenase, which is directly involved in this collagen molecule, has an enzyme. It is sulfur to make several chains of amino acids that make up this collagenase, like glue.

In other words, the sulfur component acts as an adhesive to aggregate the tissues and tissues of the skin (S-S), so that the skin retains its elasticity by collagen functional action.

3) Used as a treatment for dermatitis (dry skin, wounds, atopic skin, acne skin, etc.).

Biochemically, sulfuric acid acts on organic matter to form pentathionic acid. This substance dissolves the keratin of the skin, causing insecticidal and bactericidal action. Therefore, sulfur is a nontoxic sulfur element supplying agent, it removes inflammation and has a strong sterilizing power and plays a good role in dermatitis.

4) It alleviates the allergy phenomenon.

Vegetable sulfur (Natural Sulfur) is known to reduce many allergies, including food allergies, contact allergies, and air-contact allergies.

The 1,3-butylene glycol employed in the present invention can be used as an extraction solvent and as a substitute for the two components as a better component than propylene glycol or glycerol for technical or biological effects.

The 1,3-butylene glycol is a viscosity reducing ingredient, and forms a barrier to prevent drying as other moisturizing agents. In addition, it prevents moisture in the air of high humidity from flowing into the film formation, and also prevents the crystallization of insoluble matter in cosmetics and also helps dissolve water-insoluble matter.

More specific functions of 1,3-butylene glycol will be described in detail as follows.

First, 1,3-butylene glycol has a very good distribution coefficient, allowing the preservative to work more effectively on the formulation, making the preservative less available.

Second, 1,3-butylene glycol plays a role in preventing the decay of cosmetics by microorganisms, and butylene glycol itself has an antimicrobial effect. For example, it has an inhibitory action against Gram-positive bacteria, negative bacteria, fungi, and yeast.

Third, 1,3-butylene glycol is stable. Generally, there is no harm when applied to skin, and it is not irritating even when applied for a long time.

In summary, the 1,3-butylene glycol itself has a preservative effect, extracting substances which are not dissolved in water, and also acts as a moisturizer and preservative.

In the present invention, triethyl citrate is an antimicrobial oil and plays a role in inhibiting bacteria in the dermal layer. In addition, the triethyl citrate has a function of preventing sebum and inflammation and preventing infection.

In the present invention, niacinamide is a water-soluble vitamin B3, also known as nicotinamide, which is a kind of niacin, a vitamin B group.

The above-mentioned niacinamide simultaneously promotes the synthesis of cholesterol and fatty acid necessary for formation of lamellar structure together with ceramide, thereby reducing water loss of the epidermis and improving the lipid mass. These niacin amides are essential to our body, and vitamin B3 deficiency can cause serious skin lesions.

In particular, various effects of niacinamide on the skin act as an anti-inflammatory agent for acne, antioxidant function, light immunosuppression and photoprotection, and increase the synthesis of intercellular lipids. In addition, topical use of niacinamide can effectively reduce pigmentation of the facial skin and can lead to improvement of the underlying skin tone. This whitening effect is known not to directly affect melanin production in melanocytes but to inhibit the migration of melanocytes from melanocytes to surrounding keratinocytes.

Panthenol is another name for pantothenic acid. It is also known as provitamin B5, which is converted into vitamin after absorption into the body. There are D-Panthenol and DL-Panthenol.

One embodiment of the invention contains D-Panthenol. As an effect of D-Panthenol, it improves the moisturizing and maintaining function of the skin and stimulates the regeneration of the skin. Since the dry skin provides softness and elasticity, it is mainly used as a wetting agent, a softener and a moisturizer in cosmetics. It is also used to prevent inflammation and itching, soften hair and enhance hair strength.

Now, the manufacturing method of the present invention will be described.

The composition of the present invention can be prepared by the following extraction, mixing, and addition steps.

(1) Extraction step: A mixture of a herbal medicine comprising gold, yellow whites, gardenia, and marjoram, and gossam, chrysanthemum, and baekbokryeong are mixed with 1,3-butylene glycol and extracted at room temperature for a predetermined time to extract an active ingredient.

In the present invention, the room temperature refers to 15 to 25 캜. As a preferred embodiment, the immersion time may be 100 days, but it may be varied depending on the amount of the component.

The mixing ratio of each of the above-mentioned gold, yellowish white, gypsum and marjoram is preferably 1: 1: 1: 1 by weight, . In addition, the mixing ratio of each of gossam gambia, Chinese ginseng root, and white ginseng and 1,3-butylene glycol is preferably 3: 7 by weight.

(2) Mixing step: 8% by weight of the herbal medicine mixed extract, 6% by weight of the ginseng extract, 2% by weight of the extract of Rhododendron japonica extract in the whole composition, the herbal medicine mixed extract, the ginseng extract, , The Baekbokri extract is mixed to make up 4% by weight, and the natural organic sulfur is further mixed to make up 50% by weight of the total composition (70% by weight in the total composition)

(3) Addition step: Niacinamide, D-panthenol, and triethyl citrate were added to the extract and the sulfur mixture obtained in the above mixing step, wherein 10 wt% of niacinamide, 4 wt% of D- Ethyl citrate is added in an amount of 16% by weight. (30% by weight in the total composition)

Example

A preferred embodiment of the present invention will be described below.

The mixed extract of herbal medicines according to the present invention is obtained by mixing 70 g of each of gold, yellow-white, gingko and mashii into 700 g of 1,3-butylene glycol, and aging at room temperature for 100 days to extract the active ingredient.

In the extract of the present invention, 300 g of ginseng is mixed with 700 g of 1,3-butylene glycol, and the mixture is immersed at room temperature for 100 days to extract an active ingredient.

The extract of Rhodiola extract of the present invention is obtained by mixing 300 g of Rhodiola with 700 g of 1,3-butylene glycol and immersing it at room temperature for 100 days to extract an active ingredient.

In the extract of Baekbokryeong of the present invention, 300 g of Baekbokryeong is mixed with 700 g of 1,3-butylene glycol and immersed at room temperature for 100 days to extract an effective ingredient.

Next, the above-mentioned herbal medicine mixed extract, 8% by weight of the extract, 6% by weight of the ginseng extract, 2% by weight of the Rhodiola extract, 4% by weight of the extract of Baekbokryeong, 50% by weight of natural organic sulfur, 10% by weight of niacinamide, 4% by weight, and triethyl citrate by 16% by weight to obtain the composition of the present invention.

The composition of the present invention can be formulated as a cosmetic preparation or a preparation for acne prevention or treatment.

 Formulations of the cosmetic for preventing or treating acne include various creams, cleansing foams, whole body cleansers, soaps, packs, cosmetics and the like, such as skins, lotions, essences, nutritional creams, massage creams and cleansing creams containing the composition of the present invention as an active ingredient. A skin adhesive patch, a skin adhesive gel, a powder, a foundation, and the like.

 The formulations for preventing or treating acne include parenteral administration agents such as tablets and capsules containing the composition of the present invention as an active ingredient, oral administration agents, injections, patches, ointments, lotions and creams . ≪ / RTI >

Experimental Example

Each active ingredient of the composition of the present invention was classified as shown in the following Table 1, and the antibacterial activity and the minimum inhibitory concentration (MIC) were measured. In Table 1, the units are% by weight, and the examples show one embodiment of the present invention described above.

ingredient Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Herbal medicine mixed extract 8 - 8 8 8 8 8 Gosam extract 6 6 - 6 6 6 6 Rhodiola extract 2 2 2 - 2 2 2 Baekbokryoung extract 4 4 4 4 - 4 4 Natural organic sulfur 50 50 50 50 50 50 50 Niacinamide 10 10 10 10 10 - 10 D-Panthenol 4 4 4 4 4 - 4 Triethyl
Citrate 16 16 16 16 16 - -

<Antibacterial Efficacy Evaluation I - Experimental Example 1>

The antimicrobial effect of Propionibacterium acnes KCTC3314, a cause of acne, was measured. Antimicrobial activity was measured by agar diffusion method in which the number of growth inhibition halos around the discs was measured by placing the test solution in a plurality of discs on the solid agar medium coated with the test strain, and measuring the size of the growth inhibition halo.

The concentration of the antibacterial test was limited to 1000 ppm (0.1%), and the results are shown in Table 2 as a control group using triclosan, which is widely used as an antibacterial agent for cosmetic composition.

Subject Triclosan Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 P. acnes inhibition + ++++ +++ +++ +++ +++

   +: Transparent size less than 8mm, ++: Transparent size less than 8 ~ 12mm,

+++: Transparent table size 12mm ~ 16mm, ++++: Transparent table size 16mm or more

From the results of Table 2, it can be seen that one embodiment of the present invention containing all the active ingredients of the present invention has the strongest antimicrobial activity.

<Minimum Inhibitory Concentration (MIC) Measurement-Experimental Example 2>

The Minimum Inhibition Concentration (MIC) was measured. Propionibacterium acne cultured for 24 hours was placed in a 3 ml brain heart infusion broth, and at the same time, each of the measurement objects was added at the concentration, and then cultured at 37 ° C for 24 hours. The results are shown in Table 3, using a 2-fold dilution method, using triclosan as a control, and Comparative Example 5.

Measured object Triclosan Example Comparative Example 5 MIC (mg / ml) 0.0042 0.0012 0.0016

From the results shown in the above Table 3, it was found that the minimum inhibitory concentration was much lower than that of triclosan in all of the examples of the present invention and the comparative example 5, and in particular, one embodiment of the present invention, And the effect of suppressing acne bacterium is very excellent.

&Lt; Antibacterial efficacy evaluation II - Experimental Example 3 >

Antimicrobial effects of Propionibacterium acnes KCTC3314, which is a cause of acne, of Comparative Example 1, Comparative Examples 4 to 6 and Examples of the present invention were measured by the Agar disc diffusion method of Conner DE and Beuchat LR (Conner DE, Beuchat LR , Sensitivity of heat-stressed yeasts to essential oils plant. Appl Environ microbiol . 1984; 47: 229-33). One platinum strain was cultured on a plate culture medium and preincubated for 24 hours in 10 mL of a liquid culture medium. This was again inoculated in 1 mL of the liquid medium (9 mL), cultured, and then homogenized in the plate medium. The sterilized filter paper discs were placed on a solid plate medium, and the sterilized test samples were subcultured to a total volume of 20 / disc each with a 0.20 membrane filter. Bacteria were cultured in anaerobic condition at 37 ℃ to confirm the diameter of the clear zone around the disc.

The results were confirmed by the size of the growth zone (clean zone), and are shown in Table 4 and FIG.

Sample to be evaluated (sample) diameter (mm) Drawing display Comparative Example 5 12 A Comparative Example 1 9 B Comparative Example 4 9 C Comparative Example 6 14 D Example 15 E

 As can be seen from Table 4 and FIG. 1, the diameter of the clean zone of the present invention was the largest, proving that the antibacterial activity was the most excellent.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, It will be apparent to those skilled in the art that various modifications may be made without departing from the scope of the present invention.

A: Growth Inhibition of Comparative Example 5 B: Growth Inhibition of Comparative Example 1
C: inhibition of growth of Comparative Example 4 D: inhibition of growth of Comparative Example 6
E: Growth Inhibition of Examples of the Present Invention

Claims (4)

8% by weight of the extracted herbal medicine mixture, 6% by weight of the ginseng extract, 2% by weight of the Rhodiola extract, 4% by weight of the extract of Baekbokryeong, and 1% 50% by weight of natural organic sulfur, 10% by weight of niacinamide, 4% by weight of D-panthenol and 16% by weight of triethyl citrate;
A composition for treating acne by enhancing skin barrier and regenerating cells, which comprises extracting the herbal medicine mixed extract, ginseng extract, Rhodiola extract, and Baekbokryeong extract using 1,3-butylene glycol as an extraction solvent. delete delete (a) a mixture of herbal medicines mixed in a weight ratio of 1: 1: 1: 1 of gold, yellow whites, gardenia, and mashii, and gossam, chrysanthemum, and bongbyeol were immersed in 1,3-butylene glycol for 100 days at 15 ~ Wherein each of the golden, yellowish white, gypsum and marjoram of the herbal medicine mixture is mixed with 1,3-butylene glycol at a weight ratio of 1:10, and each of the ginseng, The mixing of the renglycol in a weight ratio of 3: 7;
(b) 8% by weight of the herbal medicine mixed extract, 6% by weight of the ginseng extract, 2% by weight of the extract of Rhodiola extract, Mixing the Baechon-rok extract so as to make up to 4% by weight, and further mixing the natural organic sulfur to make up 50% by weight of the total composition; And
(c) adding niacinamide, D-panthenol, and triethyl citrate to the extract obtained in step (b) and a natural organic sulfur mixture, wherein 10% by weight of niacinamide, 4% And adding triethyl citrate so as to occupy 16% by weight. The method for manufacturing a composition for treating acne by strengthening skin barrier and cell regeneration.

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