KR20150045599A - An antifungal composition comprising an natural fermentation material - Google Patents

Abstract

The present invention relates to an antimicrobial composition which includes a natural fermentation mixture as an active ingredient and is used against Malasseziasp fungus, a preparation method for the same, a cosmetic composition preparation method including the natural fermentation mixture as an active ingredient, and a preparation method for the same. According to the present invention, the natural fermentation mixture is prepared by naturally fermenting a natural substance or the extract of the natural substance and is highly reliable while having little risk of side effects. The natural fermentation mixture also has an excellent antifungal activity against Malasseziasp fungus causing dandruff or seborrheic dermatitis, thereby capable of reducing the scalp itch and being used in alleviating and preventing the skin diseases such as the dandruff or seborrheic dermatitis.

Description

TECHNICAL FIELD [0001] The present invention relates to an antimicrobial composition comprising a natural fermented product as an active ingredient,

The present invention relates to an antimicrobial composition and a cosmetic composition for harmful microorganisms including Malassezia sp. Fungus comprising a natural fermented product as an active ingredient.

Dermatitis means inflammation that occurs in the skin, usually used in the same way as eczema. It is divided into atopic dermatitis, contact dermatitis and seborrhoeic dermatitis. The atopic dermatitis is an eczema-like skin lesion that occurs in people with atopic eczema, which is also referred to as endogenous eczema or benignanosis. The contact dermatitis refers to inflammation of the skin caused by contact with an external substance. It is characterized by itching that the so-called skin is hung. In addition, seborrhoeic dermatitis refers to dermatitis which occurs well in areas where sebaceous secretions such as the head, forehead or armpit are high, and is also referred to as seborrhoeic eczema. It is a dermatitis mainly caused by erythema and thin scales, dandruff. The lightest type is dandruff or scaly tetter.

The dandruff occurs when a problem occurs in the general cycle of the skin cells. It is also called a dry bell, and it is a mild form of seborrheic dermatitis on a kind of scalp. It mainly occurs after puberty in which the sebaceous gland is actively active, It can occur in both men and women.

It has recently been known that the fungus causing dandruff is a fungus, that is, yeast. Especially, Malassezia sp. Yeast, which is present in the skin such as scalp and the like, is a cause of stress, , It is reported that dermatophytosis such as dyspepsia and itching occurs when the malasseous fungus is overproduced due to environmental factors such as food, and seborrhoeic dermatitis occurs when severe overgrowth is severe (Bergbrant IM Seborrhoeic dermatitis and Pityrosporum yeasts, Current Topics in Medical Mycology, 6: 95-112 (1995)). In addition, when a large amount of dandruff occurs, the scalp is excessively rubbed due to itching and the like, thereby causing scarring, inflammation and hair loss in some cases.

According to the results of the above studies, it has been found that a composition for the treatment, prevention or amelioration of dandruff and pruritus contains a component capable of inhibiting the proliferation of Malassezia sp. Ketoconazole, zinc pyrithion, itraconazole, or piroctone olamine, which are antifungal agents, have been mainly used in the present invention. In addition, tar, sulfur and salicylic acid have been used to alleviate itching and scurvy, and selenium sulfide has been used to inhibit the overgrowth of epidermal cells. However, the antifungal agents used for the treatment of dandruff have a good effect on the treatment of dandruff, but most of them are artificially synthesized, thus raising the question of human safety.

For example, ketoconazole, which is an active ingredient of dandruff remedy such as nizolol marketed in Korea, has a problem that can cause adverse effects on the endocrine system (Schuermeyer T, Nieschlag E. 1982. Ketoconazole induced drop in serum and saliva testosterone. Lancet 1098p; Janssen PAJ, Symoens JE 1983. American Journal of Medicine 74: 80-85). In addition, zinc pyrithione shows excellent effects as an inhibitor of scalp hypersensitivity and antifungal agent, but it is insoluble and has a high specific gravity. Therefore, it is difficult to inject uniformly into a composition, Fred H. Snyder et al. , Safety evaluation of Zinc 2-Pyridiethiol (1979), G. A. Hyde and M. M. Auerbach, Formulation techniques for zinc pyrithione antidandruff shampoos, Cosmetics and Toiletries, 1-Oxide in Shampoo Formulation, Toxicology and Applied Pharmacology, vol. 7, pp. 425-437 (1965), Marks, R. The effects of a shampoo containing zinc pyrithione on the control of dandruff. 415 (1985)). In particular, zinc pyrithione causes skin contact dermatitis (Nielsen, NH, Allergic contact dermatitis caused by zinepyrithione associated with pustular psoriasis, Am J. Contact Dermat, 8, 170. 1997) It has been reported that it is difficult to apply it to a hair cosmetic composition at a high concentration.

In addition, itraconazole, which has been studied to replace ketokonazole, is highly effective against many pathogenic fungi associated with humans and has high affinity for keratinous tissues (Van Cutsem J, Van Gerven F, . Zaman R, Heeres J, Hanssen PAJ Pharmacological and preclinical results with a new oral and topical broad spectrum antifungal R 51211. Proceedings of the 13 th International Congress of Chemotherapy, Vienna, Part 40: 1-11 (1983)), Lou Kane It has been reported that oral administration of oral gauze is slower because it is not transported through the sweat glands like nasal drops, and it is reported that at least 1,000 mg of a prescription is required to prevent a satisfactory therapeutic effect and recurrence (Grant SM, Clissold SP. Drugs 37: 310-344 (1989)). In addition, pyrrothonolamine, which has been studied to overcome the deficiencies of zinc pyrithione, and salicylic acid, which is mainly used as a sterilizing and keratolytic agent, have a disadvantage that the sterilizing power against causative bacteria of dandruff is weak.

In addition, most patients are prescribed several types of drugs at the same time, but dosing of the combination can affect the toxicity and immune system of the hepatocyte, and may cause problems that may increase the efficacy or adverse effects of one drug (Svejgaard E. Side effects and interactions of oral antifungals. Journal of the European Academy of Dermatology and Venereology 5, page S11 (1995); Bickers DR. Journal of the American Academy of Dermatology 31: S87-S90 (1994)), headache or nausea (Georgiou S, Monastirli A, Pasmatzi E, Zografakis C, Tsambaos D. Oral itraconazole therapy for pityriasis versicolor. Journal of the European Academy of Dermatology and Venereology 8: 203-207 (1997)).

Dandruff is not a shortening of life or serious illness, but it is the object that gives psychological stress to the majority of people. Methods or components capable of preventing or treating such dandruff have been continuously studied. However, as described above, the results of studies on ingredients that are eco-friendly, harmless to the environment and humans, and capable of reducing the number of dandelion bacteria still remain, to be.

Therefore, unlike conventional antifungal agents, they have an excellent antimicrobial activity against Malassezia sp. Fungus, which is a cause of dandruff, and have a problem of tolerance and stability which do not have side effects even if they are ingested or used for a long period of time In addition, there is a growing demand for development, improvement and treatment of dandruff symptoms resulting from natural substances that do not cause any side effects.

KR 2013-0100438 A KR 2010-0031372 A KR 2010-0129938 A KR 2013-0076723 A

The present invention has been to improve the problems of the prior art, do the cause of dandruff increased and / or seborrheic dermatitis, including natural products or fermented with the natural extracts of natural fermentation, as an active ingredient count subgenus (Malassezia sp. ) Antimicrobial composition against fungi, and dandruff and seborrheic dermatitis containing it as an effective ingredient.

In order to achieve the above object, the present invention provides a method for producing an antimicrobial composition for a harmful microorganism including Malassezia sp. Fungus , which is a causative agent of dandruff and / or seborrheic dermatitis, which comprises a natural fermented product as an active ingredient, There is provided an antimicrobial composition produced by the above production method.

The present invention also provides a cosmetic composition comprising a fermented product as an active ingredient, a method for producing at least one cosmetic composition for prevention or improvement selected from the group consisting of dandruff and seborrheic dermatitis, Thereby providing the cosmetic composition prepared.

Specifically, the method for producing the antimicrobial composition of the present invention comprises the steps of adding water to burdock seed and laurel leaf, conducting a hot water extraction method, adding sugar and vinegar to the hot water extract, and fermenting the fermented product 1; Adding honey and sugar to the hot-water extract of the acacia flower and fermenting the fermented product 2; Preparing a fermented product 3 by mixing and fermenting bamboo shoot hot water extract and sugar; Preparing a fermented product 4 by mixing fermented fruit, honey and sugar, and fermenting the fermented product 4; Mixing buckwheat and sugar syrup and fermenting to produce fermented product 5; Mixing fermented hot water extract with sugar and fermenting the fermented product 6; Mixing the pear and the brown sugar, and then fermenting the fermented product 7; And mixing the fermented product 1 to the fermented product 7 to prepare a composition for scalp.

The antimicrobial composition may be an antimicrobial composition for Malassezia sp. Fungi. The Malassezia fungus is Malassezia < RTI ID = 0.0 > furfur , Malassezia restricta , Malassezia obtusa , Malassezia globosa , Malassezia slooffiae , Malcessezia simpodia , Malassezia sympodialis and Malassezia pachydermatis. ≪ Desc / Clms Page number 2 >

The antimicrobial composition of the present invention may be one prepared by the above-mentioned preparation method. Since the antimicrobial composition has antimicrobial activity against Malassezia sp. Fungus which is a cause of dandruff, it can be used for preventing or treating dandruff and / or seborrheic dermatitis. In this respect, the antimicrobial composition may be included as an active ingredient in a detergent composition for preventing or ameliorating dandruff and / or seborrheic dermatitis. The detergent composition may be applied to the hair and / or scalp or applied to the skin.

The method of manufacturing the cosmetic composition of the present invention may further include the steps of adding water to the burdock seed and laurel leaves, performing a hot water extraction method, adding sugar and vinegar to the hot water extract, and fermenting the fermented product 1 ; Adding honey and sugar to the hot-water extract of the acacia flower and fermenting the fermented product 2; Preparing a fermented product 3 by mixing and fermenting bamboo shoot hot water extract and sugar; Preparing a fermented product 4 by mixing fermented fruit, honey and sugar, and fermenting the fermented product 4; Mixing buckwheat and sugar syrup and fermenting to produce fermented product 5; Mixing fermented hot water extract with sugar and fermenting the fermented product 6; Mixing the pear and the brown sugar, and then fermenting the fermented product 7; And mixing the fermented product 1 to the fermented product 7 to prepare a composition for scalp.

The cosmetic composition of the present invention may be one prepared by the above-mentioned production method. In addition, the cosmetic composition of the present invention may be applied to hair and / or scalp or applied to skin. In this respect, the cosmetic composition may be at least one cosmetic composition for scalp prevention or improvement selected from the group consisting of cosmetic composition for scalp, more specifically dandruff and seborrheic dermatitis.

Hereinafter, the present invention will be described in more detail.

In the present invention, an antimicrobial composition may have the same meaning as antibiotics, which is generically referred to as an antimicrobial agent, and may have the same meaning as an antifungal agent, a bactericide, an antiseptic, a preservative or a bactericidal agent, Means a substance capable of inhibiting or inhibiting pathogenic microorganisms including Malassezia sp. Fungi which cause skin diseases, in particular, development and life functions of fungi.

In the present invention, the Malassezia fungus means all the fungi belonging to the genus Malassezia , for example Malassezia fungi, Malassezia restricta , Malassezia globosa , Malassezia < RTI ID = 0.0 > furfur , Malassezia obtusa), do three years Jia Jia slow ohpiah Male Symposium (Malassezia slooffiae), Dia lease (Malassezia sympodialis , and Malassezia pachydermatis .

The inventors of the present invention have been studying for many years to improve skin diseases such as dandruff and scalp disease, and have found that when a fermented product fermented with a natural product is mixed, the skin disease can be improved without side effects or toxicity It has been confirmed that when mixed with fermented natural materials selected by the present inventors, the skin diseases such as scalp diseases including dandruff are improved remarkably, and in order to commercialize them, The present inventors completed the present invention by confirming that the antimicrobial effect was excellent as a result of an experiment commissioned by an organism,

The present invention relates to a process for producing an antimicrobial composition and an antimicrobial composition produced by the process.

The method for producing an antimicrobial composition of the present invention is characterized in that a fermented product of an extract of a mixture of burdock and laurel water, a fermented product of an acacia extract, a fermented product of a bamboo shoot, a fermented product of a curd refuse, a fermented product of buckwheat, And water.

Each of the fermented products may be mixed in an amount of 0.01 to 100, preferably 0.1 to 10, based on the volume ratio of the fermented product of the extract of burdock and laurel mixture, more preferably the same amount.

The extract of the natural product can be carried out by adding hot water extract, specifically natural product, water, for example, purified water, at 80 to 100 ° C, preferably 90 ° C for 1 to 12 hours, preferably 5 hours have.

For example, the burdock and laurel water extracts can be prepared by putting the sea urchin seeds, sea urchin seeds, and laurel leaves in purified water, hot-extraction at 90 ° C for 5 hours, cooling at room temperature, and filtering only the extract.

The burdock ( Arctium lappa , burdock) is a foliage of chrysanthemum and deciduous plants used as food for European origin. It is 50 to 150 cm high, with straight roots growing up to 30 cm to 60 cm, stem from the end, The bloom is black purple in the month, and the head is hanging on the end of the branch. The fruit is achene and ripens in September. The burdock has been used for a long time, and the main recipe has been made with pickled or stewed side dishes. The root of burdock contains mainly inulin and some palmitic acid, and has been used as a diuretic, sweating or sore throat treatment. It has been known that the above-mentioned strangers have been used as medicines in Chinese medicine as the berries, and have the effect of communicating and distributing the heat, allowing the disposal to take place, causing the bean sprouting, calming the swelling and detoxifying.

The laurel (Laurus nobilis ) is an evergreen tree of the dicotyledonous plant buttercups, which is native to the Mediterranean coast, and is also called olive tree or laurel. It grows up to about 15 meters in height. Its bark is dark ash-colored. Its branches and leaves are lush. Leaves are staggered and hard. Flowers are dioecious and smell like yellow. Flowers bloom in April or May. Shaped like an ellipse and ripened in October with a purplish purple color. It grows mainly in sunny places, with breeding as seeds and crockery, and the fruit and leaves of the laurel are used as medicines to eliminate the dryness and the boil.

The acacia fermented product can be prepared by adding acacia flowers into purified water, subjecting the mixture to hot water extraction at 90 DEG C for 5 hours, cooling at room temperature, and filtering only the extract. The acacia is a myrtle plant of dicotyledonous rosemary bean with about 500 species distributed in tropical and temperate regions, mainly in Australia. The leaves of the acacia are alternate phyllotaxis, small leaves are very small or petiole is flat, flowers are yellow or white, headstock, circle abstract or asteraceae, and the fruit is flat It is constricted or cylindrical.

The bamboo shoot fermented product can be prepared by adding bamboo shoots into purified water, subjecting to hot extraction at 90 ° C for 5 hours, cooling at room temperature, and filtering only the extract. The bamboo porout is a young lion emerging from the subterranean node of bamboo, piled up with bamboo leaves, like fish scales, and has all the traits of bamboo grown.

The fermented product of the extract of natural product was prepared in such a manner that the fermented product was naturally fermented at 15 ° C to 20 ° C in a jar so as to block the sunlight, and then filtered only through the fermentation broth.

For example, burdock and laurel water fermented products are prepared by adding brown sugar and persimmon vinegar to the above extracts of burdock and laurel water, naturally fermenting them at 15 ° C to 20 ° C for 6 months in a jar so as to block sunlight, ≪ / RTI > Also, the acacia fermented product was prepared by adding brown sugar and honey to the acacia flower hot-water extract solution, naturally fermenting the mixture in a jar for 3 years at 15 ° C to 20 ° C, and filtering only the fermentation liquid . Also, the fermented bamboo shoots were prepared by adding brown sugar to bamboo shoot hot water extract, putting them in a jar so as to block sunlight, naturally fermenting them at 15 to 20 캜 for 3 years, and then filtering only the fermentation broth.

The fermented product of Purslane fermented product was obtained by adding brown sugar to the dried bean curd hot water extract and naturally fermenting at 15 to 20 ° C for 3 years in a jar so as to block sunlight, and then filtering only the fermentation liquid.

The Portulaca oleracea ) is a fleshy annual herbaceous plant, also known as porcine ginseng, also known as Maehyeon or Maehyeong. The pairing is a one-year-old herb that grows in low mountains and fields and grows in sunny or semi-shaded hills or flat areas. Its height is about 30 cm and its leaves are 1.5 to 2.5 cm long. It has a long oval shape with rounded ends facing each other, and the flower is yellow in color. It is gathered at the end of stem or branch with 3 to 5 ends, It blooms from January to October, and the fruit grows in an elliptical shape after the flowering, and the seed is a black circle, with half of the top being poured down like a lid.

In addition, the fermented product was prepared by mixing fruit, honey and brown sugar, mixing in a jar so as to block sunlight, naturally fermenting at 15 ° C to 20 ° C for 3 years, and then filtrating only the fermentation broth.

The above-mentioned cucumber is a plant distributed in Korea, Japan or China of the nettle cucurbitaceae family. It is also called a cucumber tree or a gut thorn tree. It is a deciduous broad-leaved arboreous tree or shrub that grows in the sunny and sunny places of southern central part of Korea. It has thorns on the branches, the leaves are divided into 3 branches, the edges are plain and egg-shaped, and the bark is brown or grayish brown It grows shallowly in the vertical direction and develops the skin of the branch. The flowers of the above-mentioned Cucumispinae are dioecious in May to June. The flowers are light yellow flowers on the axil of leaves. The fruits are hard and green with berry, but are slightly reddish from September to October, . The leaf of Cucumis japonica has been used as a substitute for mulberry leaves. The fruit has been used to make jam or drink, and the bark, that is, bark and root, is used as medicinal or paper raw material.

The fermented product of buckwheat was prepared by adding brown sugar to water, mixing the brown sugar syrup prepared by boiling for 6 hours and buckwheat together, and naturally fermenting the mixture at 15 ° C to 20 ° C for 6 months in a jar so as to block sunlight, And only the fermentation broth was obtained by filtration.

The buckwheat (buck wheat, Fagopyrum esculentum ) is an annual plant of Mandelphia originating in the northern and central Asia of Northeast Asia, centered on the northeastern region of China, Manchuria, Lake Baikal, or the Amur River, and is also known as a product or hometown.

The stem of the buckwheat is 60 cm to 90 cm wide and the root is strong in drought due to chewiness or root. The leaf is triangular or heart-shaped with a pointed end, and one to three nodes beneath the main stem face each other, The flower is white in color and the flower is white or pale pink. It blooms in infinite inflorescence from July to October. In addition, the fruit is brown or dark brown when matured, and has a sharp shape. The buckwheat buckwheat is resistant to a foot or cold and has a short growth period. Therefore, the buckwheat has a high adaptability to emergency work of poor crops in the poorest and bad climate mountainous soil, and a strong storage power with high nutritive value. Many plants have been grown. The buckwheat fruit was made from buckwheat rice, which was cooked and cooked, and the powder was made from buckwheat noodles, buckwheat noodles or cold noodles. The fruit of the buckwheat has a high fiber content and rutin, which is used as an insecticide or a hypotensive agent. The young leaves are used as vegetables and the buckwheat pods are used as pillows.

The fermented product is prepared by mixing the pulverized product obtained by pulverizing the pear with a pulverizer and the brown sugar, and naturally fermenting the product in a jar for 3 years at 15 ° C to 20 ° C to filter off the sunlight, Respectively.

The stomach is the fruit of the pear tree. The pear tree (Pyrus) is a collective name of a deciduous tree or shrub in the rose and pear tree, distributed mainly in the temperate regions of Eurasia, and has about 20 species worldwide. It is largely a southern oriental type, It is divided into three kinds of breeds. In Korea, cultivars were cultivated from ancient times such as Kosirane, Imperial Ney, and Chrysanthemum.

The stomach flowers are white, the skin is brown or greenish brown, and the flesh contains stones. The fruit of the pear is composed of 2 to 5 bases, and the seed is black. Wherein the main ingredient is a carbohydrate, and the sugar content related to fructose and sucrose and the amount of the organic acid such as malic acid, tartaric acid, citric acid and the like, which is an alkaline food, is about 80% , Vitamin B, vitamin C, and the like. The abdomen is effective for bronchial diseases and is good for cold, relieving or asthma. It is known to help defecation and diuretic action, and to detoxify by detoxifying action. The above-mentioned pear is not only eaten raw but also made juice, canned food or jam, and is used for various dishes.

The antimicrobial composition may further comprise an extract of a finely divided powder.

The above-described extract of the minced crustacea can be prepared by extracting the above-mentioned minced pork with vinegar. The method for preparing the above-described extract of the present invention can be carried out by adding the above-mentioned extract to a vinegar, for example, persimmon vinegar and extracting the mixture at 15 to 20 ° C for 80 days to 100 days.

This is a one-year-old herb that originated in Mexico and is grown as a medicinal plant. The stem of the above-mentioned fineness is straight or obliquely growing from 50 cm to 150 cm and has no hairs, leaves are alternate phyllotaxis, petioles are long, 3 to 6 pairs of small leaf, small leaf is balsonic or balsonic elliptic, The flower grows from June to August in the axilla of the leaf, and two to six yellow flowers are running. The fruit is flat, with a length of about 10 cm, and protrudes on both sides. The seeds of these minced seeds are used in medicine, and the leaves are used for bites in snakes or insects in the private sector.

Vinegar, also known as a salt, has been in use for a long time and is produced by propagating acetic acid bacteria to alcoholic ingredients. Therefore, it is known that the vinegar which is mainly used in each country is deeply related with the alcoholic beverage which is widely produced in the country and the fruit which is cultivated much in the country. For example, in the United States, apple vinegar and fermented vinegar are again distilled distilled vinegar, grape vinegar in France, malt vinegar in England and Germany, or sake vinegar in Japan, and persimmon vinegar made by aging.

Persimmon vinegar is a vinegar made by fermenting persimmon. It is rich in tannin and vitamin C to lower the acidic concentration of food to increase preservative power. It stimulates secretion of digestive juice through sour taste, . The persimmon vinegar can be made by enclosing the persimmon made with persimmon in a container and aging it after aging, for example about one year. The longer the aging period, the more blackish the taste becomes, the more the organic acid content becomes.

The antimicrobial composition may contain 0.001 to 99.99% by weight, preferably 0.1 to 99% by weight, of the mixture of the natural fermentation product based on the total weight of the composition. However, depending on the method of using the antimicrobial composition and the intended use, Can be adjusted appropriately.

The antimicrobial composition of the present invention may contain carbohydrates, proteins, lipids, vitamins and minerals in addition to the natural fermentation product, which is an active ingredient of the antimicrobial composition. The saccharide may be selected from the group consisting of honey, dextrin, sucrose, palatinose, glucose, fructose, starch syrup, sugar alcohol, , Sorbitol, xylitol and maltitol. The protein may be milk-derived proteins such as casein, whey protein, soybean protein, animal-derived enzymes such as trypsin and pepsin of these proteins, and neutrase The lipid may be a first saturated fatty acid, a sunflower oil containing a polyunsaturated fatty acid, a rapeseed oil, an olive oil, a safflower oil, a corn oil, Derived fat such as soybean oil, palm oil and palm oil, middle-chain fatty acid, EPA, DHA, soybean-derived phospholipids, milk-derived phospholipids, The RAL fluids may be potassium phosphate, potassium carbonate, potassium chloride, sodium chloride, calcium lactate, calcium gluconate, calcium pantothenate, casein calcium, magnesium chloride, ferrous sulfate, sodium bicarbonate, but are not particularly limited by each example .

The saccharide, protein, lipid, vitamins, and minerals may be contained in the composition as long as the antimicrobial activity of the composition is maintained. The content of each component is not limited as long as the antimicrobial activity is maintained , Preferably 0.1 to 15% by weight, preferably 0.5 to 10% by weight, based on the total composition.

In addition, the antimicrobial composition may contain, in addition to the above-mentioned effective ingredients, a composition of various cosmetic compositions for the purpose of sterilization of Malassezia fungi, Additives, preferably in the group consisting of conventional anti-dandruff ingredients such as ketoconazole, zinc pyrithion, itraconazole, Piroctone Olamine, selenium sulfide, tar, sulfur and salicylic acid And the additional component or additive may be provided so as not to be disturbed by the other constitution of the composition.

The antimicrobial composition of the present invention can be used for various purposes and applications requiring antimicrobial activity. Specifically, the antimicrobial composition of the present invention can be used for inhibiting the growth of pathogenic microorganisms such as pathogenic fungi. , Preferably for the purpose of treatment, prevention or amelioration of disinfection of Malassezia fungus or dandruff or seborrhoeic dermatitis which is causative of Malassezia fungus.

More specifically, the antimicrobial composition of the present invention has antimicrobial activity against the causative microorganisms causative of dandruff, malecegia fungi and skin flora, and thus has remarkably excellent effect in the treatment, improvement or prevention of dandruff , It can be applied to a composition for preventing or treating dandruff, or a detergent composition or a cosmetic composition applicable to at least one selected from the group consisting of hair and scalp. In addition, since it exhibits antimicrobial activity against the causative bacteria causative of seborrheic dermatitis, which is a causative organism of the body, Malese giidia fungi and skin fungi, it is possible to provide a composition for prevention or treatment of seborrheic dermatitis and a composition for preventing or treating seborrheic dermatitis The present invention can be applied to a detergent composition or a cosmetic composition.

The present invention also provides a composition for preventing or treating dandruff, preferably dandruff, selected from the group consisting of dandruff and seborrheic dermatitis comprising the antimicrobial composition as an active ingredient. Since the mixture of natural fermented products of the present invention has antimicrobial and antifungal activity against Malassezia fungus and skin flora which are causative bacteria of Malassezia fungi and seborrheic dermatitis, the antimicrobial composition is selected from the group consisting of dandruff and seborrheic dermatitis 1 or more, preferably dandruff.

In the present invention, dandruff is a skin of the tofu, that is, the stratum corneum cell of the scalp simply comes off without inflammation and appears as a dry, moist or oily skin. Dandruff is often referred to as dandruff, and medically it is called dandruff. If the dried seaweed is aggravated, it can become dermatitis seborrheica, which can involve a large amount of dryness and itching. In addition, alopecia occurring when the dandruff caused by dry bark is chronically severe is called alopecia seborrheica. In the case of dandruff or seborrheic dermatitis, the main causative microorganism is reported to be fungus Malassezia fungus. Therefore, in order to treat dandruff or seborrheic dermatitis, it is possible to prescribe a substance having antimicrobial activity against the causative microorganism Malassezia fungus.

The composition for preventing or treating at least one selected from the group consisting of dandruff and seborrheic dermatitis of the present invention can be directly applied to animals including humans. The animal is a group of organisms corresponding to plants. It mainly consumes organic matter as nutrients. It refers to the digestion or excretion and differentiation of the respiratory organs. It may preferably be a mammal, more preferably a human.

Dandruff, and seborrheic dermatitis, the composition for preventing or treating at least one selected from the group consisting of dermatosis and seborrheic dermatitis may contain the above-mentioned antimicrobial composition alone as an active ingredient and may further contain additional components, Acceptable or nutritionally acceptable carrier, excipient, diluent or subcomponent.

More specifically, the at least one composition for preventing or treating dandruff and seborrheic dermatitis may further comprise at least one selected from the group consisting of nutrients, vitamins, electrolytes, flavors, coloring agents, agonists, pectic acid and salts thereof, alginic acid And a salt thereof, an organic acid, a protective colloid thickener, a pH adjusting agent, a stabilizer, a preservative, a glycerin, an alcohol, a carbonating agent used in a carbonated drink, and the like. The carrier, excipient or diluent may be selected from lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acicia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline In the group consisting of celluloses, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, liquid paraffin, But the present invention is not limited thereto. Any conventional carrier, excipient or diluent may be used. The components may be added to the antimicrobial composition which is the active ingredient independently or in combination.

The at least one prophylactic or therapeutic composition selected from the group consisting of dandruff and seborrheic dermatitis comprises 0.001% by weight to 99.9% by weight, preferably 0.1% by weight to 99% by weight, of the antimicrobial composition based on the total weight of the composition, May range from 1% to 50% by weight. In addition, the content of the additional component may be preferably in the range of 0.1 to 20 parts by weight per 100 parts by weight of the antifungal composition.

The composition for preventing or treating at least one selected from the group consisting of dandruff and seborrheic dermatitis may be a conventional filler, an extender, a binder, a disintegrant, a surfactant, an anticoagulant, a lubricant, a wetting agent, Or preservatives, and they can be used either orally or parenterally.

Specifically, forms for parenteral administration include parenteral preparations such as creams, ointments, dressing solutions, spraying agents, and topical administration agents such as other coating agents. Examples of the formulations of the topical administration agent include one or more compositions for prevention or treatment selected from the group consisting of an antifungal composition as an active ingredient or dandruff and seborrheic dermatitis impregnated with a carrier such as gauze made of natural fibers or synthetic fibers . In the case of parenteral preparation for parenteral administration, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Agents for parenteral administration may include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like can be used as the non-aqueous solvent and suspension agent. Examples of suppository bases include witepsol, macrogol, tween 61, cacao butter, laurin, glycerol or gelatin.

In the case of the cream or ointment, it may be suitably applied directly to the periphery of the at least one disease selected from the group consisting of dandruff and seborrheic dermatitis. In the case of the above-mentioned spray agent, it can be manufactured by a conventional spray agent manufacturing method except that it contains an antimicrobial composition as an active ingredient, and it is packed in a compression vessel or other spray vessel and sprayed on the dandruff site at various times, Dermatitis can be prevented or treated.

In addition, the formulation of at least one preventive or therapeutic composition selected from the group consisting of dandruff and seborrheic dermatitis of the present invention may be in a preferred form depending on the method of use, and in particular, Release by the methods known in the art. Examples of specific formulations include, but are not limited to, excipients, granules, lotions, liniments, limonades, handmade, liquids, aerosols, extracts, elixiers, , Fluid excipients, emulsions, premixes, infusions, eye drops, tablets, suppositories, injections, injection tablets, cataplasma, creams, troches.

Further, the at least one preventive or therapeutic composition selected from the group consisting of dandruff and seborrheic dermatitis of the present invention may be prepared using any suitable method known in the art or by the method of Remington ' s Pharmaceutical Science (recent edition), Mack Publishing Company , Easton PA). ≪ / RTI >

The dose of the at least one composition for preventing or treating dandruff and seborrheic dermatitis according to the present invention is suitably adjusted by a person skilled in the art in consideration of the administration method, the age, sex and weight of the recipient, Can be selected. For example, one or more preventive or therapeutic compositions selected from the group consisting of dandruff and seborrheic dermatitis of the present invention may be administered at a dose of 0.0001 mg / kg to 1000 mg / kg, based on the antimicrobial composition, / kg to 100 mg / kg. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

In addition, the composition for preventing or treating at least one selected from the group consisting of dandruff and seborrheic dermatitis of the present invention may further comprise a compound or plant extract having inhibitory activity against known dandruff or seborrheic dermatitis in addition to the antimicrobial composition , And 5 parts by weight to 20 parts by weight with respect to 100 parts by weight of the antimicrobial composition.

The present invention also provides a process for producing a cosmetic composition and a cosmetic composition produced by the process.

The cosmetic composition is prepared by adding water to burdock seed and laurel leaf, performing a hot water extraction method, adding sugar and vinegar to the hot water extract, and fermenting the fermented product 1; Adding honey and sugar to the hot-water extract of the acacia flower and fermenting the fermented product 2; Preparing a fermented product 3 by mixing and fermenting bamboo shoot hot water extract and sugar; Preparing a fermented product 4 by mixing fermented fruit, honey and sugar, and fermenting the fermented product 4; Mixing buckwheat and sugar syrup and fermenting to produce fermented product 5; Mixing fermented hot water extract with sugar and fermenting the fermented product 6; Mixing the pear and the brown sugar, and then fermenting the fermented product 7; And mixing the fermented product 1 to the fermented product 7 to prepare a composition for scalp.

The cosmetic composition may be applied to hair and / or scalp or applied to skin.

The fermented product 1 to fermented product 7 may be mixed in an amount of 0.01 to 100, preferably 0.1 to 10, based on the volume ratio of the fermented product 1, specifically the fermented product of the extract of burdock and laurel mixture, They can be mixed in the same amount.

The present invention also provides a method for producing a detergent composition and a detergent composition prepared by the method.

The detergent composition is prepared by adding water to burdock seed and laurel leaf, performing a hot water extraction method, adding sugar and vinegar to the hot water extract, and fermenting the fermented product 1; Adding honey and sugar to the hot-water extract of the acacia flower and fermenting the fermented product 2; Preparing a fermented product 3 by mixing and fermenting bamboo shoot hot water extract and sugar; Preparing a fermented product 4 by mixing fermented fruit, honey and sugar, and fermenting the fermented product 4; Mixing buckwheat and sugar syrup and fermenting to produce fermented product 5; Mixing fermented hot water extract with sugar and fermenting the fermented product 6; Mixing the pear and the brown sugar, and then fermenting the fermented product 7; And mixing the fermented product 1 to the fermented product 7 to prepare a composition for scalp.

The fermented product 1 to fermented product 7 may be mixed in an amount of 0.01 to 100, preferably 0.1 to 10, based on the volume ratio of the fermented product 1, specifically the fermented product of the extract of burdock and laurel mixture, They can be mixed in the same amount.

The detergent composition may be applied to the hair and / or scalp or applied to the skin.

In the present invention, hair refers to human hair as a collective term for hairs and hair, and preferably refers to hair, and may include hair follicles, hair follicles, hair, and scalp near hair follicles. In the present invention, the scalp refers to the skin covering the head region, and usually a hair (hair) region.

The detergent composition may be applied to at least one selected from the group consisting of hair and scalp, or may be applied to the skin, and may be referred to as a body cleanser composition when applied to the skin.

The detergent composition prepared by the above-mentioned preparation method may contain, in addition to the above-mentioned effective ingredients, a moisturizing agent such as a surfactant, a surfactant, a pH adjuster, a natural moisturizing component and a natural vegetable oil, Ionic sequestering agents, preservatives, solvents, flavoring agents and coloring matters. Further, the composition may contain an additional antimicrobial substance or a microbicide within a range that maintains the antimicrobial effect of the present invention and does not stimulate the human body.

The detergent composition is a composition used to remove oily and aqueous contamination or waste materials adhering to the surface of the skin, having appropriate bubble power in cold water and hot water. In recent years, moisture is evaporated and water is evaporated Such as imparting a moisturizing effect to the skin, enhancing skin flexibility, or enhancing sebum removing ability. In addition, in recent years, the skin hypersensitivity of the detergent composition has been emphasized.

In general, the inflammation of human skin is caused by the infiltration of bacteria into the sebum in the pores or by the allergic factor. When the cleaning agent composition is used for cleaning, it is possible to remove skin sebum and obtain a bactericidal effect according to the contained ingredients, Can be improved. In addition, the function of removing waste materials or sebum from the detergent composition is mainly performed by a surfactant and the prevention of bacterial infection is performed by a bactericide or an antibacterial substance. Since the bactericide or antimicrobial substance currently used is mainly a chemical synthetic substance, Sensitive skin, or when it is used excessively over a certain level, it may cause skin damage due to contact with the skin.

Accordingly, efforts have been made to replace the bactericidal or antimicrobial substance with a skin-irritant or harmless natural substance. In view of this, the detergent composition of the present invention is a mixture of a fermented product of a natural product or an extract of a natural product, There is an advantage of low stimulation on the skin.

In addition, since the fermented product of the natural substance extract exhibits excellent antibacterial activity against Malassezia fungus and the skin eradication, the detergent composition of the present invention has a cleaning and moisturizing effect, which is a basic function of the detergent composition, , Dandruff, and seborrheic dermatitis can be improved or prevented.

The surfactant may be any one selected from the group consisting of an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant.

Examples of the anionic surfactant include ammonium lauryl sulfosuccinate, ammonium lauryl sulfate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium lauryl sulfate, triethanolamine lauryl sulfate or sodium lauryl ether sulfate And so on. The nonionic surfactant may be, for example, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene, polysorbate 80, hardened castor oil derivative, fatty acid diethanolamide, glyceryl stearate and the like. The cationic surfactant may be, for example, a tertiary aliphatic amine salt, alkyltrimethylammonium chloride or dialkyldimethylammonium chloride. The amphoteric surfactant may be, for example, betaine, amide betaine, sulfobetaine or stearthrimonium chloride.

Examples of the pH adjusting agent include organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid and glycolic acid, hydrochloric acid, sulfuric acid, phosphoric acid and nitric acid, or a combination of sodium salt, potassium salt or ammonium salt thereof And may be triethanolamine, sodium chloride, sodium hydroxide, potassium hydroxide or the like.

The moisturizing agent may be a conventional oil used for moisturizing, for example, vegetable oil or liquid paraffin, or an organic solvent such as ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, sorbitol, Collagen and the like. The content of the moisturizing agent may be 0.1 to 10 parts by weight based on the total weight of the composition, but is not limited thereto.

The preservative may be, for example, benzoic acid, paraoxybenzoic acid ester, a mixture of methylchloroisothiazolinone, phenoxyethanol, DMDMH, methylparaben, ethylparaben or propylparaben.

The solvent may be, for example, purified water, ethanol, tween 20, cyclomethicone, mineral oil, or dimethicone, and the colorant and detergent may be selected from common detergents of ordinary skill in the art to which the present invention belongs The components used in the composition may be used.

In addition, the detergent composition may be formulated as a liquid, solid soap or powder.

When the detergent composition is applied to at least one selected from the group consisting of hair and scalp, the detergent composition may be a bar or tablet suitable for cleaning shampoo, rinse, shampoo and rinse mixture, treatment, soap, skin, Or a soap tablet or the like.

When the detergent composition of the present invention is used for shampoo and the like and for hair and scalp cleansing, a surfactant may be further included. The surfactant may be at least one selected from the group consisting of, for example, a synthetic anionic surfactant, an amphoteric surfactant and a nonionic surfactant, and the anionic surfactant may be an alkyl sulfate or an alkyl ether sulfate, The amphoteric surfactant may be alkyl betaine or alkylamidopropyl betaine, and the nonionic surfactant may be alkanolamide or alkylamine oxide, and the surfactant may be selected singly or in combination.

In addition, the detergent composition for hair and scalp cleansing may further include conventional components for maintaining basic physical properties and quality of cleansing applications such as shampoos, and the components may be selected from the group consisting of pearl fungus supplements, preservatives, thickeners, , a pH adjusting agent, a perfume or a dye, and the like.

The pearlescent adjuvant may be ethylene glycol monostearate or ethylene glycol distearate and the preservative may be methyl p-hydroxybenzoate, methyl chloroisothiazolinone, methyl isothiazolinone, or a mixture thereof, And the viscosity controlling agent may be sodium chloride, ammonium chloride or propylene glycol, and the pH adjusting agent may be citric acid, phosphoric acid, sodium hydroxide or potassium hydroxide, and the dye may be water-soluble tar. The detergent composition for hair and scalp cleansing may further comprise a hair conditioning agent such as polyquaternium-10, polyquaternium-7, methylpolysiloxane, dimethylconcapiol, or hydrolyzed animal protein.

The cosmetic composition may be applied to hair and / or scalp or applied to the skin, and may be, for example, a hair cosmetic composition.

When the cosmetic composition is a hair cosmetic composition, the hair conditioner, hair tonic, hair cream, hair lotion, hair face, hair gel, hair pack, hair massager, hair liquid, hair spray, hair mousse, non- aerosol mousse, non- , Aerosol mousse, aerosol spray, emulsion, decolorant, aqueous dispersion, powder or oil. The composition of each of the above-mentioned formulations may contain various kinds of bases and additives necessary for formulation of the formulation, and the kind and amount of these ingredients can be easily selected by those skilled in the art to the extent that the effect of the above- have.

When the formulation of the hair cosmetic composition is a paste, a cream or a gel, it may further contain an animal oil, a vegetable oil, a wax, a paraffin, a starch, a tracer, a cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc, .

If the formulation of the hair cosmetic composition is a powder or a spray, it may further comprise lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder, especially if the formulation is a spray, additionally chlorofluor Propellants such as hydrocarbons, propane, butane or dimethyl ether.

When the formulation of the hair cosmetic composition is a solution or emulsion, it may contain a solvent, a solubilizing agent or an emulsifying agent, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan, and the like.

When the formulation of the hair cosmetic composition is a suspension, a liquid diluent such as water, ethanol, or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, and the like.

Since the mixture of natural fermented product produced by the production method of the present invention has overall excellent antibacterial activity against not only the maleaceae bacteria which are the main cause of dandruff but also the scalp bacteria and the seborrheic dandruff disease bacteria, The present invention is not limited to the use of natural antimicrobial agents, and it can be used as a therapeutic agent for skin diseases and itching Is also excellent, it can be used variously for the hair care and personal care related industries, and the effect is industrially very high.

FIG. 1 and FIG. 2 are photographs of a scalp taken by the applicant for clinical experiment according to an embodiment of the present invention while treating a mixture of a fermented natural product during a treatment period.

Hereinafter, preferred embodiments of the present invention will be described. However, the following examples are only a preferred embodiment of the present invention, and the present invention is not limited by the following examples.

Example 1: Preparation of a mixture of natural fermented products

The extracts and natural fermentations used in the test were prepared as follows.

First, 600 g of burdock seedlings and 300 g of laurel water were added to 1 L of purified water, followed by hot water extraction at 90 ° C for 5 hours, cooling at room temperature, filtration of the extract only, 300 g of persimmon and 50 g of persimmon were added to the jar so as to block the sunlight and naturally fermented at 15 캜 to 20 캜 for 6 months, followed by filtration of the fermentation broth alone.

The acacia fermented product is obtained by extruding 2,000 g of acacia flower into 1 L of purified water, subjecting it to hot water extraction at 90 ° C. for 5 hours, cooling at room temperature, filtering only the extract, and then adding 1,000 g of brown sugar and 350 g of native honey After natural fermentation at 15 ° C to 20 ° C for 3 years in a jar so as to block sunlight, only the fermentation broth was obtained by filtration.

3,000 g of bamboo shoot fermented product was added to 3 L of purified water, followed by hot extraction at 90 ° C for 5 hours, cooling at room temperature, filtering only the extract, adding 1,000 g of brown sugar to 1,000 mL of the extract, After being naturally fermented at 15 ° C to 20 ° C for 3 years in a jar, only the fermentation broth was obtained by filtration.

In addition, the fermented product was mixed with 1,000 g of fruit, 1,000 g of native honey, and 1,000 g of brown sugar, followed by natural fermentation at 15 ° C to 20 ° C for three years in a jar so as to block sunlight, .

The buckwheat fermented product was prepared by adding 1,000 g of buckwheat and 2,000 g of brown sugar to 2 L of purified water, mixing the brown sugar syrup prepared by boiling for 6 hours together, putting it in a jar so as to block the sunlight, , And then the fermentation broth was obtained by filtration.

5,000 g of Peppermint Fermentation product was added to 5 L of purified water and subjected to hot water extraction at 90 ° C for 5 hours, followed by cooling at room temperature, filtering only the extract, adding 3,600 g of brown sugar to 3,000 mL of the extract, After being naturally fermented at 15 ° C to 20 ° C for 3 years in a jar, only the fermentation broth was obtained by filtration.

Further, 1,000 g of the pulverized product obtained by pulverizing the pear by a pulverizer, and 1,000 g of brown sugar were mixed and put into a jar so as to block the sunlight, naturally fermented at 15 ° C to 20 ° C for 3 years, Respectively.

The mixture (A) of the natural fermented product is prepared by mixing the prepared burdock and laurel water fermented product, the acacia fermented product, the bamboo shoot fermented product, the fermented product, the fermented product of buckwheat, the fermented product of the bean curd and the fermented fermented product in an equal amount based on the volume ratio .

As a natural extract for confirming the antimicrobial activity against a harmful microorganism including a dandruff of a mixture of the above natural fermented products, there are a persimmon extract (B) having a known antimicrobial effect, a herbal extract (C) of a root peel of a peony, The extract (D) and bamboo salt aqueous solution (E) were used. The extracts of persimmon, mulberry or burdock were prepared by adding 1 kg of persimmon, mulberry or burdock seeds to 1 L of purified water, hot extraction at 90 ° C for 5 hours, followed by cooling and filtration. In addition, 1 kg of bamboo salt purchased from Damyang area, Jeollanam province was dissolved in 1 L of purified water and sufficiently dissolved by filtration.

Example 2: Experimental preparation of antifungal activity of a mixture of natural fermented product

The antifungal activity of the mixture of the natural fermented product prepared in Example 1 was evaluated by the agar diffusion method using the same amount of the mixture of the natural fermented product prepared in Example 1 and the natural extract and the bamboo salt aqueous solution, Was used to measure the antifungal activity against harmful microorganisms such as skin fungus including Malassezia sp. Fungus, which is a causative organ of dandruff, and the experiment was conducted by the Oriental Industry Promotion Agency located in Jangheung, Jeollanam-do.

Example 2-1: Target strain and culture medium

The test strains including the Malassezia sp. Fungus strain were used as the strains shown in Table 1 below. The strains were purchased from the following media. Specifically, Nutriet broth and Agar were purchased from Difco, GAM broth was purchased from NISSUI, and color detection agar was purchased from MB cell.

Strain Accession number Use badge Remarks Bacillus cereus KCTC 1661 Nutrient broth, Color detection agar Scalp and skin supernatant E-coli KCTC 2593 Nutrient broth, Color detection agar Pseudomonas aeruginosa ATCC 15442 Nutrient broth, Color detection agar Propionibacterium acnes KCTC 3320 GAM broth, GAM agar Seborrheic dermatitis-inducing strain Malassezia furfur KCTC 7744 GAM broth, GAM agar

Example 2-2: Measurement of antifungal activity using a paper disk

The antifungal activity against Malassezia sp. Fungus , a causative strain of dandruff, was carried out by a flat plate diffusion method using a paper disk.

The antifungal activity was a paper disk containing a mixture of each of the natural fermented products prepared in Example 1, which is a substance to be fungicidal, and a natural extract.

First, 0.5 ml of each of the natural fermented product mixture or natural product extract of Example 1 was absorbed into a paper disk (Advantec Filter Paper, Toyo Roshi Kaisha Ltd., Japan) having a diameter of 8 mm and a thickness of 1.5 mm, The antimicrobial activity of each strain of Malassezia fungus cultured on the medium of 2-1 was tested on a smear-coated plate culture medium to test the antimicrobial activity. The cells were cultured under the optimum culture temperature conditions of each of the above strains. After culturing for 48 hours under the above conditions, the size (mm unit) of the circular growth inhibitory circle formed around the disk was measured. (*), (**), and (***) were found to have no antimicrobial activity depending on the size of the hammer rings based on the above three experimental values. Are shown in Table 2 below.

A B C D E Bacillus cereus ** * - - - E- coli * ** - - - Pseudomonas aeruginosa * * - - - Propionibacterium acnes * * - - - Malassezia furfur * - - - -

As shown in Table 2, in the case of the mixture of the natural product fermented product of the present invention, not only the Bacillus bacteria and E- coli bacteria as the skin uptake bacteria but also the Propionibacterium strains causing causative bacteria of dermatitis including dandruff The antimicrobial activity of both acnes and Malassezia furfur was shown to be excellent. On the other hand, almost no antimicrobial activity was observed in plant extracts or bamboo salt solutions, and the extracts of persimmon extracts showed excellent antimicrobial activity. However, it was confirmed that they did not have antimicrobial activity against seborrheic dermatitis, .

In this respect, the mixture of natural product fermented product of the present invention is excellent in antimicrobial activity against various skin-damaging bacteria and seborrheic dermatitis causing bacteria even though it is a natural product, and thus the natural fermented product mixture has excellent dandruff treatment, improvement or prevention effect, It has been confirmed that natural products can be used for various purposes because they are all edible.

Example  3: Natural Fermented  Experiment on the improvement of dermatitis

The effect of improving the dermatitis on the mixture of the natural fermented product prepared in Example 1, in which excellent antibacterial activity was confirmed in Example 2, was confirmed. Specifically, in the case of two men in their 40s who had seborrheic dermatitis and atopic symptoms including dandruff on the scalp residing in Gwangju Metropolitan City who volunteered for the clinical trial, the use of the existing therapeutic agent was stopped and after one week, Using a diluted solution of the prepared natural fermented product at a ratio of 1:10 (mixture of natural fermented products: water) twice a day to wash the scalp and hair in the morning and evening, a photograph of the scalp was taken, Respectively. Specifically, the scalp of two volunteers was photographed on April 20, 2013 before using the diluted 1: 10 dilution of the mixture of natural fermented product prepared in Example 1, and from April 28, 2013 to June 2013 The scalp was photographed by confirming the progress until 9th month, and is shown in Fig. 1 and Fig.

As shown in FIGS. 1 and 2, in the photographs taken before administration of the mixture of natural fermented products of the present invention, red spots and dandruff were found in the scalp and hair, while the mixture of the natural fermented products showed scalp and hair After washing for about 2 months, the red dots and dandruff disappeared, and it was confirmed that the anti dandruff effect and the dermatitis dermatitis were improved. In addition, as shown in FIG. 1, unlike before administration, on May 25, 2013, after using for about 1 month, red spot and dandruff gradually decreased, and after about 1 month of use, Day or on June 9, 2013, red spot and dandruff disappear gradually, and it was confirmed that the existing dermatitis symptom was improved, but no red spot caused by allergy or skin irritation appeared, and no side effect was confirmed.

According to the above experiment, the mixture of the natural fermented product of the present invention has excellent antimicrobial activity against the causative bacteria of the skin and seborrheic dermatitis, and thus has an excellent effect for improving dermatitis and other skin irritants, and has no side effects.

Manufacturing example : natural Fermented  Preparation of a hair composition comprising a mixture

Manufacturing example  1: Manufacture of anti-dandruff shampoo

A shampoo for preventing dandruff, comprising a mixture of said natural fermented product, was prepared with the following composition.

Mixture of natural fermentation 30 g

Cocamidopropyl betaine 20 g

Glycerin 5 g

Polyquater 2 g

Olive Liquid 5 g

Water gs 100 g

Manufacturing example  2: Manufacture of lotion for prevention of dandruff

A lotion for preventing dandruff, comprising a mixture of said natural fermented products, was prepared with a solution of the following composition.

Mixture of natural fermented product 45 g

Oil (can be selected from olive, camellia, avocado, etc.) 15 g

Olive oil wax 3 g

1 g of emulsifying wax

Water gs 100 g

Manufacturing example  3: Cleaning Body Cleanser  Preparation of composition

A body cleanser composition comprising a mixture of said natural fermentations was prepared with a solution of the following composition.

Mixture of natural fermentation 2 g

18 g of anionic surfactant

5 g of nonionic surfactant

Glycerin 7 g

3 g of sodium chloride

Natural Olive Liquid Soap 1.5 g

Fragrance 1 g

Water gs 100 g

Claims (7)

Adding water to the burdock seed and laurel leaf, performing a hot water extraction method, adding sugar and vinegar to the hot water extract, and fermenting the fermented product 1;
Adding honey and sugar to the hot-water extract of the acacia flower and fermenting the fermented product 2;
Preparing a fermented product 3 by mixing and fermenting bamboo shoot hot water extract and sugar;
Preparing a fermented product 4 by mixing fermented fruit, honey and sugar, and fermenting the fermented product 4;
Mixing buckwheat and sugar syrup and fermenting to produce fermented product 5;
Mixing fermented hot water extract with sugar and fermenting the fermented product 6;
Mixing the pear and the brown sugar, and then fermenting the fermented product 7; And
Mixing the fermented product 1 to the fermented product 7 to prepare a composition for scalp
(Malassezia sp.) Fungus. ≪ RTI ID = 0.0 > 11. < / RTI > The method according to claim 1,
The Malassezia fungus is Malassezia < RTI ID = 0.0 > furfur , Malassezia < RTI ID = 0.0 > restricta , Malassezia selected from the group consisting of Malassezia globosa , Malassezia slooffiae , Malassezia sympodialis , and Malassezia pachydermatis ), selected from the group consisting of obtusa , Malassezia globosa , Malassezia slooffiae , Malassezia sympodialis and Malassezia pachydermatis . Wherein the antimicrobial composition is at least one of the following. An antimicrobial composition for the Malassezia fungus produced by the method of claim 1. Adding water to the burdock seed and laurel leaf, performing a hot water extraction method, adding sugar and vinegar to the hot water extract, and fermenting the fermented product 1;
Adding honey and sugar to the hot-water extract of the acacia flower and fermenting the fermented product 2;
Preparing a fermented product 3 by mixing and fermenting bamboo shoot hot water extract and sugar;
Preparing a fermented product 4 by mixing fermented fruit, honey and sugar, and fermenting the fermented product 4;
Mixing buckwheat and sugar syrup and fermenting to produce fermented product 5;
Mixing fermented hot water extract with sugar and fermenting the fermented product 6;
Mixing the pear and the brown sugar, and then fermenting the fermented product 7; And
Mixing the fermented product 1 to the fermented product 7 to prepare a composition for scalp
≪ / RTI > A cosmetic composition produced by the method of claim 4. 6. The method of claim 5,
The cosmetic composition is a cosmetic composition for scalp. The method according to claim 6,
Wherein the cosmetic composition for scalp is at least one cosmetic composition for scalp preventing or improving selected from the group consisting of dandruff and seborrheic dermatitis.

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