CN111388405B

CN111388405B - Oil-control acne-removing composition

Info

Publication number: CN111388405B
Application number: CN202010455320.1A
Authority: CN
Inventors: 刘山; 李宁; 邱菊兰; 尹全尹; 向文浩; 萧月玲
Original assignee: Guangzhou Bese Clean Cosmetics Manufacturer Co ltd
Current assignee: Guangzhou Bese Clean Cosmetics Manufacturer Co ltd; Yachun Guangzhou Biotechnology Co ltd
Priority date: 2020-05-26
Filing date: 2020-05-26
Publication date: 2021-08-17
Anticipated expiration: 2040-05-26
Also published as: CN111388405A

Abstract

The invention relates to an oil-controlling acne-removing composition, which belongs to the technical field of cosmetic preparation and comprises the following components: lactobacillus/pear juice fermentation product filtrate, white willow bark extract, phellodendron bark extract, houttuynia cordata extract, Japanese beauty berry fruit extract, matrine, centella asiatica extract, scutellaria baicalensis root extract, royal jelly oil control composition, olive leaf extract, peony root extract, Chinese bulrush leaf extract, bergamot leaf extract. According to the invention, through reasonable preparation of various nutritional ingredients, the number of skin active sebaceous glands can be reduced, the grease secretion capacity of the skin active sebaceous glands can be durably regulated, and a good oil control effect is achieved; meanwhile, the acne-curing cream has the effects of shortening the acne curing time, more obviously inhibiting acne, conditioning and maintaining the skin, realizing anti-acne and maintaining stability and effectively reducing acne repetition.

Description

Oil-control acne-removing composition

Technical Field

The invention belongs to the technical field of cosmetic preparation, and particularly relates to an oil-controlling acne-removing composition.

Background

The formation of pox is often the result of the combined action of a plurality of factors, mainly related to genetic factors, endocrine factors, facial cleanness and sanitation, eating habits, long-term mental stress, mood fluctuation, learning and living environment and other factors, and the factors can easily cause sebum metabolic disturbance, excessive skin grease secretion, hyperkeratosis of hair follicles and sebaceous glands, so that hair follicle mouths are narrowed, blocked and dead cells are accumulated, so that a large number of microorganisms are bred and gathered, inflammation is caused, and finally the acne and the pox are caused. Therefore, oil control and acne removal are two important ways for treating the skin problems at present, and the purpose of oil control is to radically prevent and solve the acne problem by regulating the secretion of skin grease and restoring the physiological balance of skin; the aim of removing acne is to dredge pores by inhibiting the growth of microorganisms, thereby improving the problems of acne and acne which cause inflammation of skin.

The best state of the face is water and grease balance, excessive oil control leads the skin to lack grease, the sebaceous gland sends out a large amount of oil discharge instructions for keeping the water and the grease balanced state, the water also obtains corresponding instructions to reduce the water consumption, and the reverse circulation is adopted, so that the aim of desiring to control the oil is realized, and the promotion mode of increasing the grease is realized. Over-cleaning does not lead to refreshing skin, but leads to fatness, even leads to skin barrier damage due to over-cleaning, and then leads to various skin problems, such as sensitivity, water deficiency, skin aging and the like, and acne is inevitable repeatedly.

Disclosure of Invention

In order to overcome the problems in the background art, the invention provides the oil-controlling acne-removing composition, which can repair the damaged skin in the acne-growing and acne-removing processes, maintain the skin state and effectively avoid the repetition of acne while controlling oil and removing acne to a certain degree.

In order to realize the purpose, the invention is realized by the following technical scheme:

the oil-control acne-removing composition comprises the following components: lactobacillus/pear juice fermentation product filtrate, white willow bark extract, phellodendron bark extract, houttuynia cordata extract, Japanese beauty berry fruit extract, matrine, centella asiatica extract, scutellaria baicalensis root extract, royal jelly oil control composition, olive leaf extract, peony root extract, Chinese bulrush leaf extract, bergamot leaf extract.

The oil-control acne-removing composition comprises the following components in parts by weight: 5-10 parts of lactobacillus/pear juice fermentation product filtrate, 2-4 parts of white willow bark extract, 5-14 parts of phellodendron bark extract, 5-12 parts of houttuynia cordata extract, 3-10 parts of Japanese beautyberry extract, 1-6 parts of matrine, 3-14 parts of centella asiatica extract, 2-6 parts of scutellaria baicalensis root extract, 0.1-4 parts of royal jelly oil control composition, 0.5-2 parts of olive leaf extract, 2-6 parts of peony root extract, 1-2 parts of Chinese ash leaf extract and 0.5-3 parts of bergamot leaf extract.

The royal jelly oil-control composition comprises 1, 3-butanediol, 10-hydroxydecanoic acid, sebacic acid and 1, 10-decanediol in a weight ratio of 80-82: 4-8: 4-6: 4-8.

The oil-control acne-removing composition is applied as a skin care product additive.

The action mechanism or the characteristics of the effective components of the invention are as follows:

lactobacillus/pear juice fermentation filtrate and white willow bark extract: the plant active substance extracted from pear juice lactobacillus leavening is rich in sugar, lactic acid and mineral substances, and has effects of smoothing skin, promoting metabolism, improving skin elasticity, keeping moisture and reducing wrinkle. The two can not only increase the moisture of the horny layer, but also mildly remove the horny layer and dredge pores.

Phellodendron amurense bark extract: has anti-inflammatory effect, can directly resist the muscle base to relieve pockmarks, can promote the generation of collagen, combines the oxidation resistance of the collagen, and maintains the skin stable.

The houttuynia cordata extract: the plant component with anti-inflammatory effect is effective in inhibiting acne deterioration.

Beautyberry fruit extract: helps to resist oxidation of skin, prevent sebum oxidation, resist inflammation, promote inflammation elimination, and accelerate skin repair.

Matrine: has antimicrobial activity, can rapidly kill facial parasitic flora such as Propionibacterium acnes and mites which are led to comedos, and has better effects of diminishing inflammation, resisting acne, resisting bacteria and the like.

Centella asiatica extract: the centella asiatica is rich in asiaticoside, has the effect of promoting the activity of scar fibroblasts, and can fade scars; it has good inhibitory effect on glucuronidase, and can resist bacteria, diminish inflammation and effectively relieve skin sensitivity.

Radix scutellariae extract: can inhibit elastase, eliminate free radicals, and resist oxidation, thereby improving skin metabolism and skin elasticity; promoting cerebral amide, improving sebum and softening skin; has effects in inhibiting dermatitis, enhancing skin resistance, and resisting inflammation; can neutralize released histamine, and has effect in preventing allergy.

The royal jelly oil-controlling composition comprises: the composition is used for rebuilding sebum balance of acne-prone skin, can show superior oil control effect by combining lactobacillus/pear juice fermentation product filtrate and white willow bark extract, and has effects of regulating sebum balance, inhibiting acne bacteria and other bacteria, inhibiting bacteria and removing acne (pox).

Olive leaf extract: can protect skin cells from being damaged by ultraviolet rays and effectively maintain the skin to be tender and elastic.

Peony root extract: the compound has an inhibiting effect on metalloprotease and elastase and an activating effect on cathepsin, and both the inhibiting effect and the activating effect show that the compound has the functions of activating skin and resisting oxidation; has better contraction effect on collagen fiber gel, and shows that the collagen fiber gel has an astringent effect on the dermis layer of the skin. In addition, peony root also has antibacterial, anti-inflammatory and antiallergic effects, and can promote blood circulation and keratinocyte regeneration, and make skin permeable and smooth. Has good effects of improving skin fineness, whitening skin and shrinking pores, and can resist skin aging caused by peroxidation.

Extract of leaves of Amur bristlegrass: the oil secretion frequency can be controlled, thereby reducing the oil secretion amount. Meanwhile, the skin care product has the effects of sterilizing and resisting inflammation, and is capable of conditioning the skin and finally keeping the skin in a good water-oil balance state.

Bergamot leaf extract: has effects in supplementing water, keeping moisture, resisting oxidation, promoting skin metabolism, delaying aging, and inhibiting pigmentation.

The invention has the beneficial effects that:

the oil-controlling and acne-removing composition provided by the invention is reasonably prepared from various nutritional ingredients, starts from the formation principle of acnes and acnes, regulates the sebum balance of skin at the initial stage, reduces the number of active sebaceous glands of the skin, reduces the grease secretion capacity of the active sebaceous glands of the skin, and achieves a good oil-controlling effect. For the growing period of the acne, the active ingredients quickly permeate into the basal layer to directly act on the root of the acne, resist bacteria and diminish inflammation, improve skin microcirculation, dredge pores, balance grease secretion and promote quick removal of the acne. In addition, the composition can resist skin aging and abnormal keratinocyte metabolism caused by peroxidation and ultraviolet injury, maintain the functions of protective barriers, including maintaining skin pH, hydration and lipid membrane, conditioning and stabilizing the health state of skin, realizing anti-acne and stabilization, and effectively avoiding repeated acne.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, preferred embodiments of the present invention will be described in detail below to facilitate understanding of the skilled person.

The specific components and parts by weight of the compositions of examples 1-3 and comparative examples 1-3 are shown in Table 1.

TABLE 1 concrete components and parts by weight of compositions of examples 1-3 and comparative examples 1-3

The oil-controlling and acne-removing compositions of examples 1 to 3 and comparative examples 1 to 3 shown in table 1 were prepared by a conventional method, and were added to the same type of emulsion, respectively, to conduct a skin use test, and each composition was subjected to test evaluation according to the following stability judgment criteria, according to the following criteria. The evaluation method comprises the following steps:

1. inhibition of oil secretion test

Test samples: the compositions of examples 1 to 3 and comparative examples 1 to 3 were added to the same type of emulsion to prepare test samples.

The test method comprises the following steps: 60 oily or mixed skin subjects were selected, aged 20-35 years, and randomly divided into 6 groups (10 per group), each group being coated with different test samples (examples 1-3, comparative examples 1-3). The test samples were administered to the subjects once a day, morning and evening, for 28 consecutive days. Before and 28 days after the use, the oil content of the skin surface of the forehead part is respectively detected by an oil measuring instrument for 3 times, the average value is taken, the reduction of the oil content of the skin surface is calculated, and the test evaluation result is shown in table 2.

Table 2 results of the oil secretion test

As can be seen from Table 2, after 28 days, the skin surface oil secretion was significantly reduced using the emulsions to which the compositions of examples 1 to 3 were added, as compared with those of comparative examples 1 to 3, indicating that the compositions of the present invention synergistically act to effectively control sebum secretion.

2. Antibacterial testing

In order to verify the effect of the composition in the antibacterial aspect, the composition for improving skin acne and inflammation, which is disclosed in examples 1-3 and comparative examples 1-3 of the invention, is subjected to antibacterial performance measurement by referring to GB15979-2002 hygienic Standard for Disposable sanitary articles appendix C4 'test method for antibacterial performance of dissolution antibacterial (bacteriostatic) product':

1) test samples: the sample from test 1 was still used.

2) Preparation of bacterial suspension: and washing a 24-hour culture of the propionibacterium acnes by using 0.03mol/L phosphate buffer solution to prepare 104-106 CFU/mL bacterial suspension.

3) Respectively taking 1g of test sample, adding 0.1mL of the bacterial suspension, uniformly coating and mixing, starting timing, adding 9mL of 0.03mol/L phosphate buffer solution after 20min, fully and uniformly mixing, taking 3 dilutions, respectively taking 1mL of the dilutions, placing the dilutions in two parallel plates, adding corresponding culture medium, and culturing for 24 hours at 36 +/-1 ℃ under anaerobic condition to count bacterial colonies. The above experiment was repeated 3 times, and the average was taken and a blank control group was set.

The calculation formula of the bacteriostatic rate is as follows: and X is (A-B)/A X100%, wherein X is the bacteriostasis rate, A is the average recovered colony of the control sample, and B is the average recovered colony of the test sample.

The evaluation criteria for efficacy were: (1) the bacteriostatic rate is more than or equal to 90 percent; (2) the bacteriostasis rate is 50-90% effective; (3) the bacteriostasis rate is less than 50 percent, which is ineffective.

The results of the antimicrobial efficacy testing of the emulsions prepared from the compositions of examples 1-3 and comparative examples 1-3 are shown in table 3.

TABLE 3 results of the antibacterial test

As can be seen from Table 3, the emulsions of examples 1-3 have significant bacteriostatic effects on Propionibacterium acnes, indicating that the composition of the present invention, with a scientific ratio, can significantly inhibit the proliferation of Propionibacterium acnes and can effectively prevent or improve the acne symptoms of the skin.

3. Oxidation resistance test

This experiment evaluates the antioxidant properties of the compositions of the present invention by determining their ability to scavenge hydroxyl and superoxide radicals.

Test samples: the compositions of examples 1,3, 6, 9, 12, 15, 18 and comparative examples 1,3, 5 were mixed and diluted with ultrapure water to give a test solution having a mass fraction of 3%.

The test method comprises the following steps:

hydroxyl radical scavenging experiments: taking 0.5mL of absolute ethanol solution of o-diazaphenanthrene with the concentration of 0.75mmol/L into a test tube with a plug, respectively adding 2mL and 1mL of phosphate buffer solution with the pH of 7.4 and the concentration of 0.2mol/L into the test tube, fully and uniformly mixing the test samples, and adding 0.5mL of FeSO with the concentration of 0.75mmol/L into the test tube₄·7H₂O solution, mixed again and then added with 0.5mL of 0.01% (v/v) H₂O₂After being put in a constant-temperature water bath at 37 ℃ for 60min, the absorbance values of the mixed solutions are respectively measured at 536nm and recorded As As, and distilled water is used for replacing a sample solutionThe absorbance value of the solution used as a blank is recorded as A_bReplacing H with distilled water₂And measuring the absorbance value An of the O as a damage group, and calculating the hydroxyl radical clearance of the test sample according to the following formula: hydroxyl radical scavenging rate (%) [ (As-An)/(A)_b-An)]X 100%, the average of three measurements was taken. The test results are shown in table 4.

Superoxide radical scavenging assay: adding 5mL of 50mmol/L pH8.2 phosphate buffer solution into a stoppered test tube at constant temperature of 25 deg.C, adding 0.2mL of preheated 50mmol/L pyrogallol, mixing immediately, and measuring absorbance A at 325nm every 30s₀Measuring to 5 min; respectively adding 1mL of sample solution, adding 0.2mL of preheated 50mmol/L pyrogallol, immediately mixing, measuring the absorbance A1, and calculating the clearance rate according to the following formula: clearance%₀-A₁)/A₀100%. The average of three measurements was taken. The test results are shown in table 4.

TABLE 4 Oxidation resistance test results

As can be seen from Table 4, the compositions of the examples of the invention have strong scavenging ability for hydroxyl free radicals and superoxide free radicals, while the comparative compositions have weak scavenging ability for free radicals, which shows that the composition of the invention can effectively scavenge active oxygen free radicals by compounding, has good antioxidation, and reduces oxidative stress reaction during acne attack or other skin inflammations, thereby inhibiting acne and inflammatory reactions.

In conclusion, compared with the comparative examples, the oil-controlling and acne-removing compositions obtained in examples 1 to 3 have more prominent effects of regulating the reduction of skin oil secretion, persistently regulating the reduction of skin oil secretion, shortening the acne curing time and obviously inhibiting acne, and particularly, the effect of example 2 is more ideal. Tests show that the skin oil secretion regulating agent has high capability of regulating skin oil secretion from the root, greatly reduces the oil secretion of sebaceous glands by reducing the number of active sebaceous glands, and is continuously and effectively used. Experimental results show that the composition can show the optimal oil-controlling and acne-removing effects through the ideal matching combination of the functional raw materials, and the effect and the time for curing acne are superior to those of a comparative example. Meanwhile, the composition can also maintain the skin state, effectively inhibit acne and reduce the repeated attack probability of acnes. Through analysis, the effect of the composition is synergistic effect among the components, and as the action purposes, ways and mechanisms of the functional raw materials in the active ingredients are different, if the total dosage proportion of the functional raw materials is too small or the dosage proportion of part of the components is less, the synergistic effect is lower; the total dosage proportion of the functional raw materials is too high or the dosage proportion of part of the components is too high, antagonism is possibly generated, and the action effect of the composition is finally reduced; the optimal ideal synergistic effect exists between the raw materials with the functions only when the raw materials with the functions are in the proper dosage proportion.

Finally, it is noted that the above-mentioned preferred embodiments illustrate rather than limit the invention, and that, although the invention has been described in detail with reference to the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the scope of the invention as defined by the appended claims.

Claims

1. The composition for controlling oil and removing acnes is characterized in that: the coating comprises the following components in parts by weight: 5-10 parts of lactobacillus/pear juice fermentation product filtrate, 2-4 parts of white willow bark extract, 5-14 parts of phellodendron bark extract, 5-12 parts of houttuynia cordata extract, 3-10 parts of Japanese beautyberry extract, 1-6 parts of matrine, 3-14 parts of centella asiatica extract, 2-6 parts of scutellaria baicalensis root extract, 0.1-4 parts of royal jelly oil control composition, 0.5-2 parts of olive leaf extract, 2-6 parts of peony root extract, 1-2 parts of Chinese ash leaf extract and 0.5-3 parts of bergamot leaf extract; the royal jelly oil-controlling composition comprises 1, 3-butanediol, 10-hydroxydecanoic acid, sebacic acid and 1, 10-decanediol in a weight ratio of 80-82: 4-8: 4-6: 4-8.

2. Use of the oil-controlling and acne-removing composition of claim 1 as a skin care product additive.